#METABOLOMICS WORKBENCH amroilaiwy_20160817_185648_mwtab.txt DATATRACK_ID:704 VERSION 1 CREATED_ON November 17, 2016, 3:33 pm #PROJECT PR:PROJECT_TITLE The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated PR:PROJECT_TITLE fatty acid PR:PROJECT_TYPE GC-MS non targeted qualitative analysis PR:PROJECT_SUMMARY Introduction Alpha-1-adrenergic receptors (α1-ARs) are G-protein coupled PR:PROJECT_SUMMARY receptors (GPCRs) with three highly homologous subtypes (α1A, α1B, and α1D). PR:PROJECT_SUMMARY Of these three subtypes, only the α1A and α1B are expressed in the heart. PR:PROJECT_SUMMARY Multiple pre-clinical models of heart injury demonstrate cardioprotective roles PR:PROJECT_SUMMARY for the α1A. Non-selective α1-AR activation promotes glycolysis in the heart, PR:PROJECT_SUMMARY but the functional α1-AR subtype and broader metabolic effects have not been PR:PROJECT_SUMMARY studied. Objectives Given the high metabolic demands of the heart and previous PR:PROJECT_SUMMARY evidence indicating benefit from α1A activation, we chose to investigate the PR:PROJECT_SUMMARY effects of α1A activation on the cardiac metabolome in vivo. Methods Mice were PR:PROJECT_SUMMARY treated for 1 week with a low, subpressor dose of A61603, a highly selective and PR:PROJECT_SUMMARY potent α1A agonist. Cardiac tissue and serum were analyzed using a non-targeted PR:PROJECT_SUMMARY metabolomics approach. Results We identified previously unrecognized metabolic PR:PROJECT_SUMMARY responses to α1A activation,most notably broad reduction in the abundance of PR:PROJECT_SUMMARY polyunsaturated fatty acids(PUFAs) and endocannabinoids (ECs). Conclusion Given PR:PROJECT_SUMMARY the well characterized roles of PUFAs and ECs in inflammatory pathways, these PR:PROJECT_SUMMARY findings suggest a possible role for cardiac α1A-ARs in the regulation of PR:PROJECT_SUMMARY inflammation and may offer novel insight into the mechanisms underlying the PR:PROJECT_SUMMARY cardioprotective benefit of selective pharmacologic α1A activation. PR:INSTITUTE University of North Carolina PR:DEPARTMENT McAllister heart Institute, Department of Internal medicine PR:LABORATORY Multiple Centers PR:LAST_NAME Ilaiwy, Willis PR:FIRST_NAME Amro, Monte PR:ADDRESS 111 Mason Farm road, Chapel Hill, North Carolina, 27599-7126, USA PR:EMAIL amroilaiwy@gmail.com, monte_willis@med.unc.edu PR:PHONE 210-596-0171 PR:FUNDING_SOURCE NIH, Fondation Leducq #STUDY ST:STUDY_TITLE The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated ST:STUDY_TITLE fatty acid-Heart raw data ST:STUDY_TYPE GC-MS non-targeted metabolomic profiling ST:STUDY_SUMMARY Studies of skeletal muscle disuse either in patients on bed rest or ST:STUDY_SUMMARY experimentally in animals(immobilization) have demonstrated that decreased ST:STUDY_SUMMARY protein synthesis is common, with transient parallel increases in protein ST:STUDY_SUMMARY degradation. Muscle disuse atrophy involves a process of transition from slow to ST:STUDY_SUMMARY fast myosin fiber types 6 . A shift toward glycolysis, decreased capacity for ST:STUDY_SUMMARY fat oxidation, and substrate accumulation in atrophied muscles have been ST:STUDY_SUMMARY reported as has accommodation of the liver with an increased gluconeogenic ST:STUDY_SUMMARY capacity. Recent studies have modeled skeletal muscle disuse by using cyclic ST:STUDY_SUMMARY stretch of differentiated myotubes (C2C12), which mimics the loading pattern of ST:STUDY_SUMMARY mature skeletal muscle, followed by cessation of stretch.We utilized this model ST:STUDY_SUMMARY to determine the metabolic changes using non-targeted metabolomics analysis of ST:STUDY_SUMMARY the media. We identified increases in amino acids resulting from protein ST:STUDY_SUMMARY degradation (largely sarcomere) that occurs with muscle atrophy that are ST:STUDY_SUMMARY involved in feeding the Kreb’s cycle through anaplerosis. Specifically, we ST:STUDY_SUMMARY identified increased alanine/proline metabolism (significantly elevated proline, ST:STUDY_SUMMARY alanine, glutamine, and asparagine) and increased -ketoglutaric acid, the ST:STUDY_SUMMARY proposed Kreb’s cycle intermediate being fed by the alanine/proline metabolic ST:STUDY_SUMMARY anaplerotic mechanism. Additionally, several unique pathways not clearly ST:STUDY_SUMMARY delineated in previous studies of muscle unloading were seen, including: 1) ST:STUDY_SUMMARY elevated ethanolamine and elevated keto-acids (e.g. 2-ketoleucine and ST:STUDY_SUMMARY 2-keovaline) represent intermediates in the Ehlrich amino acid degradation ST:STUDY_SUMMARY pathway, which feeds into a metabolic pathway supplying acetyl-CoA and ST:STUDY_SUMMARY 2-hydroxybutyrate (also significantly increased); and 2) elevated guanine, an ST:STUDY_SUMMARY intermediate of purine metabolism, was seen at 12 hours unloading. Given the ST:STUDY_SUMMARY interest in targeting different aspects of the ubiquitin proteasome system to ST:STUDY_SUMMARY inhibit protein degradation, this C2C12 system may allow the identification of ST:STUDY_SUMMARY direct and indirect alterations in metabolism due to anaplerosis or through ST:STUDY_SUMMARY other yet to be identified mechanisms using a non-targeted metabolomics ST:STUDY_SUMMARY approach. ST:INSTITUTE University of North Carolina ST:DEPARTMENT McAllister Heart Institute ST:LABORATORY Mutliple Centers ST:LAST_NAME Ilaiwy, WIllis ST:FIRST_NAME Amro, Monte ST:ADDRESS 111 Mason Farm road, Chapel Hill, North Carolina, 27599-7126, USA ST:EMAIL amroilaiwy@gmail.com, monte_willis@med.unc.edu ST:PHONE 919-3607599 #SUBJECT SU:SUBJECT_TYPE Animal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - UCSF-01005 Treatment:Vehicle SUBJECT_SAMPLE_FACTORS - UCSF-01006 Treatment:Vehicle SUBJECT_SAMPLE_FACTORS - UCSF-01009 Treatment:Vehicle SUBJECT_SAMPLE_FACTORS - UCSF-01010 Treatment:Vehicle SUBJECT_SAMPLE_FACTORS - UCSF-01013 Treatment:Vehicle SUBJECT_SAMPLE_FACTORS - UCSF-01014 Treatment:Vehicle SUBJECT_SAMPLE_FACTORS - UCSF-01017 Treatment:Vehicle SUBJECT_SAMPLE_FACTORS - UCSF-01018 Treatment:Vehicle SUBJECT_SAMPLE_FACTORS - UCSF-01003 Treatment:A61603 SUBJECT_SAMPLE_FACTORS - UCSF-01004 Treatment:A61603 SUBJECT_SAMPLE_FACTORS - UCSF-01007 Treatment:A61603 SUBJECT_SAMPLE_FACTORS - UCSF-01008 Treatment:A61603 SUBJECT_SAMPLE_FACTORS - UCSF-01011 Treatment:A61603 SUBJECT_SAMPLE_FACTORS - UCSF-01012 Treatment:A61603 SUBJECT_SAMPLE_FACTORS - UCSF-01015 Treatment:A61603 SUBJECT_SAMPLE_FACTORS - UCSF-01016 Treatment:A61603 #COLLECTION CO:COLLECTION_SUMMARY Mice were sacrificed under deep isoflurane anesthesia, blood was collected by CO:COLLECTION_SUMMARY cardiac puncture, clotted, and 100–200 μL serum was snap frozen in liquid CO:COLLECTION_SUMMARY nitrogen. The heart was dissected, the atria and great vessels were excised,and CO:COLLECTION_SUMMARY the ventricles were allowed to beat in cold PBS to clear blood. #TREATMENT TR:TREATMENT_SUMMARY N/A #SAMPLEPREP SP:SAMPLEPREP_SUMMARY sample extract reconstituted in solvents containing a series of standards at SP:SAMPLEPREP_SUMMARY fixed concentrations to ensure injection and chromatographic consistency. One SP:SAMPLEPREP_SUMMARY aliquot was analyzed using acidic positive ion conditions, chromatographically SP:SAMPLEPREP_SUMMARY optimized for more hydrophilic compounds. The extract was gradient eluted from a SP:SAMPLEPREP_SUMMARY C18 column (Waters UPLC BEH C18-2.1 × 100 mm, 1.7 μm) using water and SP:SAMPLEPREP_SUMMARY methanol, containing 0.05 % perfluoropentanoic acid (PFPA) and 0.1 % formic acid SP:SAMPLEPREP_SUMMARY (FA). Another aliquot was also analyzed using acidic positive ion SP:SAMPLEPREP_SUMMARY conditions,however it was chromatographically optimized for more hydrophobic SP:SAMPLEPREP_SUMMARY compounds. In this method, the extract was gradient eluted from the same C18 SP:SAMPLEPREP_SUMMARY column using methanol, acetonitrile, water, 0.05 % PFPA and 0.01 % FA and was SP:SAMPLEPREP_SUMMARY operated at an overall higher organic content. Another aliquot was analyzed SP:SAMPLEPREP_SUMMARY using basic negative ion optimized conditions using a separate dedicated C18 SP:SAMPLEPREP_SUMMARY column. The basic extracts were gradient eluted from the column using methanol SP:SAMPLEPREP_SUMMARY and water #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE GC CH:INSTRUMENT_NAME Waters Acquity CH:COLUMN_NAME Waters Acquity BEH C18 (100 x 2mm, 1.7um) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:MS_COMMENTS - MS:INSTRUMENT_NAME Agilent 5975 MS:INSTRUMENT_TYPE Single quadrupole MS:MS_TYPE EI MS:ION_MODE POSITIVE #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Peak values (scaled) MS_METABOLITE_DATA_START Samples UCSF-01005 UCSF-01006 UCSF-01009 UCSF-01010 UCSF-01013 UCSF-01014 UCSF-01017 UCSF-01018 UCSF-01003 UCSF-01004 UCSF-01007 UCSF-01008 UCSF-01011 UCSF-01012 UCSF-01015 UCSF-01016 Factors Treatment:Vehicle Treatment:Vehicle Treatment:Vehicle Treatment:Vehicle Treatment:Vehicle Treatment:Vehicle Treatment:Vehicle Treatment:Vehicle Treatment:A61603 Treatment:A61603 Treatment:A61603 Treatment:A61603 Treatment:A61603 Treatment:A61603 Treatment:A61603 Treatment:A61603 1-2-Dilinoleoyl-Gpc (18:2/18:2) 178159184 258327312 145162256 206920000 271013696 201033616 210164752 161643472 231678352 216464976 216868832 140950672 227644832 219655392 226917456 200272960 1-2-Dioleoyl-Gpc (18:1/18:1) 146796480 124697144 84864032 130246616 90806208 166122736 90505120 73310624 81587856 128162352 157052816 103717112 99252976 107909496 138986640 146327280 1-2-Dioleoyl-Gpe (18:1/18:1) 6452171 5881873 2515734 5746239 2862262 8018837 4233187 1277189 1732825 6703574 7697228 1902055 2050626 1977769 5857755 5349081 1-2-Dipalmitoyl-Gpc (16:0/16:0) 508021120 456127712 517444416 461604768 543978176 554013440 522853632 534365504 478549376 523606112 527711328 528641056 612823168 590694144 512046112 451462912 1-2-Distearoyl-Gpc (18:0/18:0) 4537015 5048184 4099379 4701831 3919808 4909416 3795313 3885706 3164026 4693413 4810416 3883833 4233406 4093575 3998793 4814763 1-5-Anhydroglucitol (1-5-Ag) 5610405 4985602 3612214 4717229 4299166 5025253 5887883 4721445 4835121 4647448 4843369 4870244 4090761 4512473 4652964 4817654 1-(1-Enyl-Oleoyl)-Gpe (P-18:1) 4685639 4629060 4810049 5363719 4720604 6944399 5658407 4912587 3020913 4983088 5997561 4637755 5895055 6174417 5128198 5303437 1-(1-Enyl-Palmitoyl)-2-Arachidonoyl-Gpc (P-16:0/20:4) 64091272 59287416 62407364 61208444 54731576 78619344 55137056 60957012 46943720 72341920 65099048 54024504 59394948 68379064 70431592 65473368 1-(1-Enyl-Palmitoyl)-2-Arachidonoyl-Gpe (P-16:0/20:4) 61185368 67044348 71278768 64657400 70973760 76779736 69742880 63940592 51767240 69980672 74114560 59333676 67531640 75804848 73936552 65461208 1-(1-Enyl-Palmitoyl)-2-Linoleoyl-Gpc (P-16:0/18:2) 36317812 38992724 21674370 36568692 29098470 39878232 29823308 23784084 22904898 38937732 40731072 22627292 29828146 30686554 39898048 33346120 1-(1-Enyl-Palmitoyl)-2-Linoleoyl-Gpe (P-16:0/18:2) 15202064 16810798 13934128 14760848 16483675 18647540 16997784 14160726 12708699 16221395 17579160 12509770 16126780 17478864 18352212 15311228 1-(1-Enyl-Palmitoyl)-2-Oleoyl-Gpc (P-16:0/18:1) 29198140 24636424 22797672 27858090 22734096 30761324 24308566 23163992 16533761 30722524 30697148 24315924 23980668 29503600 27715292 23582436 1-(1-Enyl-Palmitoyl)-2-Oleoyl-Gpe (P-16:0/18:1) 13394279 12908908 11474553 12751961 12362257 14540799 12689681 10346826 8811087 12733424 14638795 10928369 12252346 13054553 13035308 11004570 1-(1-Enyl-Palmitoyl)-2-Palmitoyl-Gpc (P-16:0/16:0) 13128048 11990881 10206794 12466367 10487779 14993845 12053800 10761495 7904546 13253441 14842038 9724787 12276598 13353909 13108196 11422579 1-(1-Enyl-Palmitoyl)-Gpc (P-16:0) 10695000 9548931 9760920 11685175 9687025 12507059 11263913 11425049 7383100 10807610 12015823 10943901 13157863 12804187 9902127 11076135 1-(1-Enyl-Palmitoyl)-Gpe (P-16:0) 13897145 13596471 14772868 14403991 14324672 17016000 15284964 13762869 9548767 13898815 16454330 13864123 15026218 15923355 13921779 13972447 1-(1-Enyl-Stearoyl)-2-Arachidonoyl-Gpe (P-18:0/20:4) 37433968 39857944 46842436 39386352 39970888 47091600 47115132 42917672 30690480 40469092 40503224 37839720 43032844 49145640 43830752 39027016 1-(1-Enyl-Stearoyl)-2-Linoleoyl-Gpe (P-18:0/18:2) 17002932 20961982 20065800 20526676 21149804 22758562 23164460 20909276 15305881 21168174 22306940 17229732 18252564 24473204 21966024 19207666 1-(1-Enyl-Stearoyl)-2-Oleoyl-Gpe (P-18:0/18:1) 3051069 3159914 2592808 3514807 2772316 3704988 3113267 2545021 2249745 3285996 3355094 2575920 3254930 3658126 3327532 3070119 1-(1-Enyl-Stearoyl)-Gpe (P-18:0) 3769633 6531282 10687619 7867397 7360347 1550382 6890699 9750433 745692 2909961 4062516 1260925 2983058 3002996 5110394 4997572 1-Arachidonoyl-Gpc (20:4) 46464616 179474544 48290620 72820024 26064970 64731604 48074400 53285560 62254400 43395400 53087216 81709792 20501188 37278076 34349040 177203936 1-Arachidonoyl-Gpe (20:4) 30294520 38434768 20935884 33276624 18830648 24715810 29417354 25816834 25559016 34084472 20454434 29039700 19598690 35584416 19851760 29120294 1-Arachidonoyl-Gpi (20:4) 8433493 8934471 48805248 43041240 38539412 7217586 14921710 55008408 10890835 11382800 31942036 9317678 7754353 15629326 10869621 11929702 1-Arachidonylglycerol (20:4) 1369169 1201045 4994318 5694269 3658296 1287505 2459100 6750445 1688225 1595712 5484015 1761134 1017873 2374577 2192398 1706401 1-Dihomo-Linolenylglycerol (20:3) 1240808 908650 2391365 3798761 2372006 955434 1210923 5811406 1361418 1367084 3335700 1394615 1207593 2264071 1276255 1091394 1-Dihomo-Linoleoylglycerol (20:2) 643503 363595 2443667 2832995 1854031 640576 983153 5041451 890330 814686 1988282 980786 754298 1286564 894065 806804 1-Docosahexaenoylglycerol (22:6) 2763393 2451452 13062536 12746211 6990885 2833556 6719415 21374416 3690356 4565109 11870577 5927433 3295517 5670412 4831481 4962918 1-Lignoceroyl-Gpc (24:0) 837903 1556980 874347 809566 873340 1010089 854550 830287 768473 741813 1003721 930069 790393 762772 906655 1628253 1-Linolenoyl-Gpc (18:3) 1950835 6107068 1603041 2632108 1664801 1932673 1311508 1495997 2653709 2153628 1743085 2513317 1756377 1677504 1503778 5887653 1-Linoleoyl-2-Arachidonoyl-Gpc (18:2/20:4) 185464864 215151888 194667504 182252352 193809808 213555808 229840528 152498640 162977712 200435184 197836320 153798144 204551040 252169792 202965792 193175808 1-Linoleoyl-Gpc (18:2) 130752272 417663040 98615368 141939712 88904456 137601488 95735880 101149144 141737184 118382184 103583248 166221776 104721056 105960144 98052480 413256000 1-Linoleoyl-Gpe (18:2) 14173005 20147544 13501614 16337502 15471317 15666355 16257972 12065316 13215548 13996988 16171611 13736415 14614609 16298574 14663309 17024666 1-Linoleoyl-Gpi (18:2) 1305071 1584222 7025792 6724976 7738746 1064466 2656500 6366655 1514590 2056886 5784361 1426379 1476802 2182391 1956486 2150336 1-Linoleoylglycerol (18:2) 18775270 10787557 57612512 88593232 50848136 14395129 43941656 127103888 39125680 27408460 80975056 27581210 25513168 39462828 36112996 27978720 1-Methylguanidine 29482260 42579992 26984592 45515324 49691588 39610712 24809908 36473088 38303644 52984364 58276844 26577070 50085368 27094760 22053808 31505084 1-Methylhistidine 80960880 105712152 79666336 85460504 90660152 101457248 125889696 99423688 71763512 72469760 101832080 87293152 72701896 82481696 112671896 109258440 1-Methylimidazoleacetate 1080913 1577422 917141 907499 458837 1390505 1061525 1300223 929765 1056547 589459 639576 405842 945657 1257152 1441644 1-Methylnicotinamide 2153793 2580659 2453263 2009098 1943702 1806703 2399070 1754555 2658760 3290693 2842341 2831058 1943456 1553529 2467447 2779693 1-Myristoylglycerol (14:0) 1662121 768732 3751748 3462705 3506433 1686173 1725913 3787427 2258174 1462614 3404528 1879819 1428948 2094936 3333157 1388545 1-Oleoyl-2-Linoleoyl-Glycerol (18:1/18:2) 14341910 9956480 11586951 16502873 12915524 13344757 33312132 19672308 23905530 20804030 18125660 22255700 18387598 17828620 29322660 19573838 1-Oleoyl-2-Linoleoyl-Gpc (18:1/18:2) 370169760 396521952 362347840 357163872 498495872 399828160 494684832 356966336 350925952 368132288 432906272 294887360 476604096 514219616 419717760 372231520 1-Oleoyl-2-Linoleoyl-Gpe (18:1/18:2) 38111596 50237728 30638364 43969040 52962608 49704376 44541640 27816546 39487732 40411972 54497796 28768708 38743360 45885456 52732564 37021720 1-Oleoyl-3-Linoleoyl-Glycerol (18:1/18:2) 98420096 60076048 51424448 102664144 65639804 80904016 118575360 82278808 18513988 145686464 126550280 82520384 99488496 76345200 150466016 115443088 1-Oleoyl-Gpc (18:1) 102341224 223367280 76083216 112272816 67274680 111363576 82709640 72249520 76255856 84335088 97498896 113365616 87135392 92320168 88383392 238595968 1-Oleoyl-Gpe (18:1) 29068430 28885340 26831484 32119276 30355968 35321776 33021230 24488232 21155996 26808180 36555136 28191254 33993712 36780916 31392698 28601842 1-Oleoyl-Gpg (18:1) 1166815 1132553 4962181 5610719 3156888 1485160 2784446 3777410 1349617 1578661 4983096 1216492 1274593 2131200 1927295 1658849 1-Oleoyl-Gpi (18:1) 543543 452523 2996189 3739162 2396061 544636 663622 1499850 308283 472675 2090375 412918 132139 320164 477322 550533 1-Oleoylglycerol (18:1) 31693060 16818436 77765232 124962888 64070320 18352944 77821664 173354080 37808716 40092344 85380992 36604336 31127136 45225920 44803904 40895592 1-Palmitoleoyl-2-Linoleoyl-Gpc (16:1/18:2) 57377264 85535624 38706000 57158064 60476284 63408056 54520112 41044124 59682508 63111892 65847148 48977164 60507708 50345288 63409652 84299096 1-Palmitoleoyl-Gpc (16:1) 11708970 28786644 7860838 11837034 6934454 11389055 8346528 7905050 10003426 10322383 10213572 12563535 9644408 8283296 8596353 32597324 1-Palmitoleoylglycerol (16:1) 1479484 502430 2690711 5036725 2443417 1124635 1748456 3987006 1499930 1505281 5435242 1728278 1178538 1980396 1887874 1677672 1-Palmitoyl-2-Arachidonoyl-Gpc (16:0/20:4) 1016797824 1166855808 1268312832 1005467200 1176807040 1082054784 1186417536 1077695488 1079223040 1074990720 1000722048 1048446720 1197607168 1257180032 983814976 1103563776 1-Palmitoyl-2-Arachidonoyl-Gpe (16:0/20:4) 42895540 46362260 42538200 43042564 46793080 49381944 46172396 33298842 36115072 44712336 49146712 35594088 41659016 48500120 47596252 44729280 1-Palmitoyl-2-Linolenoyl-Gpg (16:0/18:3) 60209 46200 N 51271 N 85991 91245 N 74884 N N 37909 63712 93071 N 51316 1-Palmitoyl-2-Linoleoyl-Glycerol (16:0/18:2) 5115550 4312381 5938197 6300456 7961937 4819677 9390185 8333807 7910333 6625949 7027152 7706676 8784384 5889000 11690772 6891350 1-Palmitoyl-2-Linoleoyl-Gpc (16:0/18:2) 1010726912 1412263424 1033812736 1117621120 1431402240 1088705664 1250926208 1003632256 1405760896 1151426688 1146268544 1126957312 1266248320 1247288064 1123023232 1286012160 1-Palmitoyl-2-Linoleoyl-Gpe (16:0/18:2) 43266004 58699696 42120960 50917968 66923820 51513260 52045708 34703340 48503736 51432736 57930704 37401260 47673088 49086588 54659768 42491712 1-Palmitoyl-2-Linoleoyl-Gpg (16:0/18:2) 4974559 4749171 4076574 5545161 6159417 4594236 5893606 4379252 5573137 5618155 5909648 4244597 4948848 4467323 6547441 5271860 1-Palmitoyl-2-Oleoyl-Gpc (16:0/18:1) 1292588032 1339528960 1182069888 1205003776 1273415424 1411650048 1310886272 1042340608 1185163520 1308015232 1425127808 1208624896 1350613504 1375272320 1313790976 1291002240 1-Palmitoyl-2-Oleoyl-Gpe (16:0/18:1) 20532094 20248460 16153151 19919602 19377358 23298406 19951328 13565052 14070683 19672574 22830792 17269468 17830704 19025034 21477400 17466154 1-Palmitoyl-2-Oleoyl-Gpg (16:0/18:1) 5905860 5381308 5323058 5902842 5059421 6242138 4966001 7322914 5490536 4606001 6981538 6662027 7052451 5172704 4512984 5992301 1-Palmitoyl-2-Palmitoleoyl-Gpc (16:0/16:1) 78147232 73769440 57946652 70074176 63692676 83168840 72725696 54457804 62361584 73424072 81946632 64530124 70163584 69999368 69749744 73054032 1-Palmitoyl-2-Stearoyl-Gpc (16:0/18:0) 78173376 78053408 73388376 73192344 72647600 96131776 77580304 68953384 57829648 78675896 87922656 71538064 86857112 93125432 77530224 78884528 1-Palmitoyl-Gpc (16:0) 496304480 861370816 481267040 566940352 422507296 510062176 420922720 450172544 415244640 476658208 502507680 568928320 513371936 471491104 431725568 876001344 1-Palmitoyl-Gpe (16:0) 33115968 37860744 38245000 37366748 37558504 38485564 36533164 32435680 26741754 34688900 42060252 35307808 37433672 36765168 31917190 37537604 1-Palmitoyl-Gpg (16:0) 4357279 5810390 27280092 23072548 23491660 5976919 9004137 20391120 4906646 5558209 20981266 4960941 5664301 9086009 6542189 6599140 1-Palmitoyl-Gpi (16:0) 611031 465014 4804367 3436706 3505200 601599 822774 2479092 491463 819330 2353493 272221 395503 410470 375428 717180 1-Palmitoylglycerol (16:0) 18365778 16201034 57714104 95150152 45882840 16263621 38704688 92869456 30923140 27054332 71800824 21725712 26843150 36232088 33658512 26568456 1-Stearoyl-2-Arachidonoyl-Gpc (18:0/20:4) 1111289856 1214432256 1431532288 1057377344 1206544768 1224378368 1270215296 1133827200 1068423360 1152752512 1146739072 1078982784 1256339328 1402828928 1112491136 1196768000 1-Stearoyl-2-Arachidonoyl-Gpe (18:0/20:4) 406355424 437607584 471514720 403189632 495158048 483858528 470026400 399661152 359685568 433270624 447563360 385087680 445730368 518742656 427363552 391382336 1-Stearoyl-2-Arachidonoyl-Gpi (18:0/20:4) 11307252 9962391 9834890 9435797 10489980 10116636 10047167 10400705 10761427 9928845 10428158 7801379 8492023 10548001 10541765 10764442 1-Stearoyl-2-Arachidonoyl-Gps (18:0/20:4) 37029392 38183500 46826984 36945824 40912132 45531920 42709776 41306504 30133424 39115984 43362712 37313892 41479092 46703504 39656144 39350588 1-Stearoyl-2-Linoleoyl-Gpc (18:0/18:2) 687315584 1018807424 661396800 699673408 892679680 715240000 818842752 638614272 818657728 723029120 754548224 654301120 760918592 820917056 760176064 791730624 1-Stearoyl-2-Linoleoyl-Gpe (18:0/18:2) 108161944 135661200 106772672 120991432 157989312 125679560 128993368 87789520 109796544 113868880 141577840 88264736 112076696 121229968 124491304 104915088 1-Stearoyl-2-Oleoyl-Gpc (18:0/18:1) 468430368 451719104 428075232 428840128 433490400 500075072 457921312 344384352 380290944 458208288 505395360 400079488 454143040 491565312 433749024 430825344 1-Stearoyl-2-Oleoyl-Gpe (18:0/18:1) 18657240 17018242 17603686 17547428 17495084 21003312 16994252 14471188 12415219 17348808 20062800 15577453 16729687 18504896 17591156 16142042 1-Stearoyl-Gpc (18:0) 309758496 478724704 315379392 326422336 265398192 309213760 294519264 312969760 245473632 302912352 311342624 344217056 320026240 327616544 265909632 456107456 1-Stearoyl-Gpe (18:0) 81629520 80435424 95072656 88628568 96379368 94873144 95921096 83801440 65165576 84704504 101516544 83734544 95850776 102394160 85761848 83412768 1-Stearoyl-Gpg (18:0) 1354935 1629115 8815650 6365773 6677272 1767868 3137544 7407537 1475607 1577412 6393909 1977459 1929772 3676734 1877690 1917014 1-Stearoyl-Gpi (18:0) 7254059 7162196 29843534 39073972 24517424 7356198 10504550 25013380 7354146 8948631 25645552 7249113 6947264 7975571 6608321 7684402 1-Stearoyl-Gps (18:0) 4166423 4386893 16612214 16723023 14698232 4253910 6553601 12713569 4104809 4835597 12546942 4215933 3634175 4887344 4284465 5498679 10-Heptadecenoate (17:1N7) 32750476 25111100 98396240 113769848 87298872 31656704 50127380 109832800 47554460 40071280 106986424 41132640 45531780 65764536 41269440 36252420 10-Nonadecenoate (19:1N9) 27252702 21371480 103967320 126739024 81489864 28541964 36537032 140388224 36905848 31643844 85930488 30781292 36409036 57276776 32506344 31350784 12-13-Dihome 1247579 887592 1245294 1708252 1683759 1212355 1196442 1301651 1709096 1436805 1543717 1337320 1953141 1390281 1315129 1372945 12-Hete 62474820 76408472 75672632 73613800 85738464 71457912 48149872 110752712 59234772 31219116 102416512 50483144 87180216 144035968 27020710 31943108 13-Hode + 9-Hode 40965744 29842658 38360520 63100088 51557988 37475944 46974792 65159072 99684096 56134212 52271984 54776732 78499936 67587016 43617688 42120116 14-Hdohe/17-Hdohe 15639008 15699006 25035186 20936548 22189002 18152104 16972004 41943008 18139888 13055917 30025278 22889448 26937034 33191104 11175973 14227732 15-Methylpalmitate 16230558 14280962 46840216 40669804 40222872 17075194 18726706 28940242 12457371 16009036 42855780 11815876 17341438 21105470 19838620 18989640 17-Methylstearate 4543369 4402079 15500412 18130940 16007355 5010702 5858941 19435508 4330091 5416073 12917505 3902227 4482968 6133133 6122860 5415884 2^-Deoxyadenosine 5^-Monophosphate 257217 285883 296654 273819 184375 250090 215368 235576 306442 277600 168842 325103 277452 286225 205960 233368 2^-Deoxycytidine 7187377 10035744 8415160 8147251 9779835 9068915 8529923 8120997 9995988 9275383 8368173 7161965 6983377 7751069 8264930 8939164 2^-Deoxyguanosine 70664 87662 88456 84069 98097 96349 51310 75002 125822 101838 91407 120440 98865 95086 65709 74273 2^-Deoxyinosine 88860 121541 109542 133647 144430 111078 96061 90638 137695 134990 100910 90999 144444 116977 88297 93383 2^-Deoxyuridine 507575 627644 591688 522124 674295 518408 527934 479734 625090 639067 519161 495175 531866 474863 508172 537160 2-Aminoadipate 33327670 48483060 17887136 34783120 31247828 32654576 26495772 27254720 32683098 33753088 30570520 24590334 23700824 23094746 35177368 36630564 2-Aminoheptanoate 2397896 2526016 2735859 3068021 2364592 2581033 2459055 2107227 2802883 2828155 2857449 2621287 2960264 2903310 2568738 2420972 2-Aminooctanoate 350609 459328 360249 563039 379881 292133 243246 397762 547425 251008 254101 434552 141197 300359 413341 419743 2-Aminophenol Sulfate 81750 42807 65943 71560 115252 116772 23413 26616 116323 61981 54772 27229 124067 68693 60489 102179 2-Arachidonoylglycerol (20:4) 1203552 1096607 4995717 3940100 3619526 878175 1853866 4924420 1579127 1166046 4523381 1168672 701835 1149597 1415417 879858 2-Docosahexaenoylglycerol (22:6) 1117213 N 5268199 6680693 3678135 1495753 N 11977833 1973938 2108203 5563687 3014836 1586295 2285805 N 1220734 2-Hydroxy-3-Methylvalerate 48922 67922 65082 53890 84895 137288 115500 94194 64385 89244 84869 N 75121 116958 74864 42524 2-Hydroxyadipate 271098 460775 414314 388357 684756 522097 591831 347621 458194 620146 469325 283273 493576 498939 330760 318169 2-Hydroxybutyrate/2-Hydroxyisobutyrate 1156866 1323464 1273843 1276055 1561597 1586276 1485393 1776934 1440765 1334369 1599530 1194386 1669224 1479376 1470699 1495795 2-Hydroxydecanoate 223770 251617 280414 177069 314684 453773 231519 226564 266183 153036 175577 196689 338452 522543 364931 293835 2-Hydroxyglutarate 17591846 2066331 2412964 13217359 4027900 21800070 1658608 7586911 19586336 9857942 21313448 8300683 20061218 26604552 451553 5914047 2-Hydroxyoctanoate 71220 159024 87885 69201 115743 66083 N 51997 N 38217 N 41983 214395 92587 78190 53825 2-Hydroxystearate 2808398 3217166 12979584 9550783 7703226 2993472 4374349 10120740 2551808 3313808 8332369 2434497 2913617 5187557 3729530 3529794 2-Linoleoylglycerol (18:2) 17621032 11036316 57812520 91556712 54615444 13926276 35729516 115516272 38532584 27702470 84236416 24649540 20970060 26383118 30467332 22129380 2-Methylcitrate/Homocitrate 491447 575443 685588 487684 585986 660735 439055 440604 416210 478163 521872 378693 506907 551669 519815 447347 2-Methylmalonyl Carnitine 49925556 47346568 54482596 53358064 55394688 54587768 51321496 52159696 49973344 54713668 50860760 48659252 49034184 49662800 47444612 52241824 2-Oleoylglycerol (18:1) 36568100 20007972 72092240 142071568 53973120 23289264 44763752 144397680 39728072 41304104 112532584 29435050 31108140 41044176 40029740 33584004 2-Palmitoleoyl-Gpc (16:1) 721480 1530587 396035 510987 402133 739051 350449 350505 506931 388741 489484 739092 549091 393477 528988 1641739 2-Palmitoleoylglycerol (16:1) 1310387 459183 2043274 4263228 2096094 973125 1179471 3329072 1246262 1540480 4418006 1569347 1245741 1633439 1089206 1105159 2-Palmitoyl-Gpc (16:0) 31940886 56039960 20007104 33476966 25544188 26824952 23133436 19178888 22943678 25805348 27091234 30080998 24059448 25320372 21482710 49818008 2-Palmitoylglycerol (16:0) 16361877 10518412 48964352 55100344 37284928 13711805 27588166 66366936 32436438 18136688 55297220 22848162 23498928 31665700 16138838 15374370 2-Phosphoglycerate 9095012 9774394 11785965 8416482 15493901 7807225 8434336 7111172 12905710 11346710 11203817 8761156 9446409 10896118 10312424 5768388 2-Piperidinone 1703372 2106022 2866371 2039810 1804355 2004347 2250507 2575979 2050476 1957175 1666354 2730839 1706194 1732443 1526880 2456110 3^-Dephosphocoenzyme A 112893 118499 90922 71499 110987 147255 130905 55248 N 99706 91505 68899 104917 61731 180700 120074 3-(3-Hydroxyphenyl)Propionate Sulfate 231960 241732 235163 310269 242548 366565 324173 245540 387646 641910 395409 253486 426822 234575 432035 229958 3-(4-Hydroxyphenyl)Lactate 1903750 2316858 3490275 2824203 2195216 2652596 1841557 1302916 2113777 2117044 3371193 1486846 3449068 2179455 2157687 2160926 3-(4-Hydroxyphenyl)Propionate N 43520 79648 73728 89705 38239 46795 37283 54962 81228 47155 61404 69603 52170 52445 39683 3-Aminoisobutyrate 1654220 1433287 970604 905208 2031962 1143049 760659 850215 N 1357435 1254392 979413 1195054 1072410 1749181 1560136 3-Hydroxy-3-Methylglutarate 2481484 2712638 3590802 2974348 4115565 2737698 2529952 3056152 2873214 3452412 2952892 2309436 2903622 2367310 2663391 2441015 3-Hydroxybutyrate (Bhba) 5008681 3950630 1720679 1376745 1699540 4227172 9388648 6809706 2260972 1521333 1908558 2742080 3352938 3680534 5159242 3472609 3-Hydroxybutyryl Coa 27146 21099 N N N 30544 81715 39468 N N N 20592 26891 19394 35445 N 3-Hydroxybutyrylcarnitine (1) 284824544 203373728 132703560 83593160 104376928 216995008 490427072 348971328 162879472 96341680 121732448 183687184 223477808 206332352 262547504 181582352 3-Hydroxybutyrylcarnitine (2) 78097664 61112344 22313516 26404356 26156052 101004528 170261344 64320416 69686584 38722784 27462744 48015632 35951768 63232276 79529296 53958312 3-Hydroxydecanoate 4748601 4710019 1653610 2252836 2202412 6756406 7762819 4559913 4507359 3087861 1866288 3398929 2604431 3879244 4428418 3535149 3-Hydroxyisobutyrate 684021 738055 977302 747634 941573 974976 944365 1140144 539531 882931 1150837 485600 1001448 854075 1088873 934181 3-Hydroxylaurate 10774054 10037247 3316622 5024496 4996218 17269280 18037128 10018919 12178596 7030866 4396657 8421487 5560505 9937857 8923874 6630318 3-Hydroxymyristate 28698684 22536798 19445814 25830872 24034296 44453484 34600044 37611900 35424572 17570314 24791836 21206488 18835520 32950040 16821612 14756108 3-Hydroxyoctanoate 1116427 1136344 445054 547952 527105 1614608 1839771 1287519 1104439 722275 424242 946484 603293 1021659 943741 819336 3-Hydroxypalmitate 23242366 22506820 65518596 58134908 57003080 26340140 32888224 60182184 28037320 21754680 48940592 20749272 18412140 34894136 9738075 10538581 3-Hydroxystearate 3955642 4693338 11397087 8621255 8934767 4224881 5216278 5215021 4722478 3228055 7910544 3935794 4038410 3394959 3441402 3685384 3-Indoxyl Sulfate 352811 221924 443547 448837 654831 992437 354610 551422 320305 177734 409468 191524 813988 866183 828660 252523 3-Methylhistidine 26168452 33774372 25526792 26966972 21417868 33962972 37327492 37231272 20840266 22457002 23567144 21984258 23518692 33960328 34484760 28993344 3-Phosphoglycerate 74445160 78002560 83504488 76510904 97352448 77480824 71059704 69057064 92221024 91679080 85698048 78602136 78755904 85515296 78313544 67131752 3-Ureidopropionate 3580662 8772183 3787545 9217918 7166380 4662280 2387041 4312353 5455281 5517534 3810474 2230071 2784724 2139883 2937754 4844535 4-Cholesten-3-One 3290148 3011369 3392257 2859582 2746851 2855956 2978252 3326828 3621420 3729528 3672814 3313410 4280473 3425437 2582281 2956836 4-Guanidinobutanoate 18210176 18962836 24722442 20945084 17113748 18542634 18893020 17031130 24947980 23078994 19486988 24565232 23582196 20430032 19108554 21497316 4-Hydroxy-2-Nonenal 2436777 2680865 3972427 2327489 2162540 2142782 3002450 2744117 2763432 2208485 2867883 2680139 2345643 2222621 2727582 2717444 4-Hydroxy-Nonenal-Glutathione 3446932 3790261 3509318 3238969 3946878 4015112 4358572 3251887 4066263 3918320 3587813 3611682 4187577 4180137 3677003 3718535 4-Hydroxybutyrate (Ghb) 2887512 2549271 2270806 2156838 2078550 2987820 3129467 1957456 2499287 2223467 1638851 2467782 2753546 3110710 3125611 2912836 4-Hydroxyglutamate 5813009 8890461 8893442 7967832 9406357 8660275 9146107 8606579 8868777 9586449 10764671 9460915 11206361 9844037 7709377 6573516 4-Hydroxyphenylpyruvate 47161 47908 126018 79025 59539 58814 57548 55839 57688 56251 62197 56281 64203 52145 46530 63163 4-Imidazoleacetate 7798944 7342726 13972061 8320670 7518443 8675026 9687785 8320309 10128785 8839328 10302616 11018933 9513219 9336736 10352756 10455038 4-Vinylphenol Sulfate 122056 118470 132883 418799 116592 235334 126166 N 186543 216909 N 144481 N 140858 91614 N 5-(2-Hydroxyethyl)-4-Methylthiazole 198058 221681 299267 313637 319341 205002 132203 177738 286879 299419 246645 258131 296969 238331 109164 207994 5-Aminovalerate 12099557 23331186 27768636 28826246 18798424 28907834 14573628 N 22164116 24028286 17667388 14024676 22618168 21838086 13238869 19522148 5-Dodecenoate (12:1N7) 1195798 1219924 500195 751447 930557 1268341 1615985 1664192 1290091 1071825 572547 1165435 937546 1238084 1036046 1129214 5-Hydroxylysine 2402960 3559695 2875616 3142863 3814165 2842203 3008818 2530297 2504864 2282228 2577327 2139265 1689356 2946857 2541589 2922118 5-Methyl-2^-Deoxycytidine 440500 670175 659185 613724 518673 571725 504938 644284 876873 759139 471589 519721 500062 493748 525138 685025 5-Methylcytidine 1693470 1251007 1718143 1144683 1556339 1001472 2040455 1795915 2129061 1759995 1886929 2301873 1932609 2238146 1475782 1126242 5-Methylthioadenosine (Mta) 66134824 75362064 77969984 83088320 100524816 83864056 79850992 64838636 81446992 80063120 76342400 70113920 81818296 72344392 83230216 76060856 5-Oxoproline 16681244 18665864 18818528 21164782 18321772 20510060 22770460 21631050 16366447 16389833 20043760 19491732 16694900 26182672 20351678 22242594 6-Phosphogluconate 733343 695935 693875 779443 724412 713672 930588 617181 891931 753361 702149 798418 966527 1019663 965392 913310 7-Hydroxycholesterol (Alpha Or Beta) 5293463 24470008 5842661 4224564 5007334 5390332 5806730 4345344 5421236 6006026 5050084 4585268 6539388 6226517 4627353 4985174 7-Methylguanine 938191 1037635 934295 1016973 1085101 901986 1082790 1125495 1040249 900133 1007476 1211356 591332 786315 1178046 1161522 8-Hydroxyoctanoate 147532 96220 119227 122133 161683 135850 126162 168722 242764 125537 172672 153895 235806 186283 126973 153214 9-10-Dihome 462018 394199 398187 590330 432423 474802 482273 539293 874633 639597 489318 655376 834320 479936 652646 555904 Acetyl Coa 63438 77666 79980 83552 117789 77067 77420 62084 53772 89417 135517 55012 102115 81879 103424 82483 Acetylcarnitine 787913280 906165248 1490120576 1164551680 1757151360 1114051072 860796864 946673920 1256197632 1179202432 1992034176 884053504 1260052864 1232949504 1218994176 1073402304 Acetylcholine 4908138 5261840 5156111 5474139 3661094 4297428 5577389 6734325 4199358 5554728 4606981 4875786 4969864 4926280 4547844 6709060 Acetylphosphate 14725048 14917049 14769067 24520620 27127008 16572126 12477410 12899740 24751628 28628584 15404629 16332881 17264526 13637984 16244288 22842258 Adenine 347807648 364888416 254104048 399798336 298504704 402859104 320537056 353147040 336879232 381795328 377565280 374754528 407764512 427146688 310925696 234947248 Adenosine 3537609216 3807867136 1310622720 4659869696 1905678848 4678989824 3206873600 4487663616 3150742272 3779681792 3158625280 3927763200 4086857984 4827265024 2855218944 2588347392 Adenosine 2^-Monophosphate (2^-Amp) 1013223 834490 1353728 1335705 1026346 1049723 459144 502694 1312413 1207496 778439 1087473 1099279 1111138 383906 614457 Adenosine 3^-5^-Cyclic Monophosphate (Camp) 127239 160601 98663 107424 106916 136753 138772 104558 127409 155074 122962 117253 125956 128578 149644 148024 Adenosine 3^-5^-Diphosphate 4551660 4970593 4714229 3757960 3986341 5257984 3705487 3937974 3539378 4190269 4099434 3923653 4603935 4951468 4228028 3509394 Adenosine 3^-Monophosphate (3^-Amp) 1198952 1448415 1358358 1109084 1117578 1462753 1545782 1024384 1097328 1233558 1026980 1126325 1261560 1056118 1448230 1379722 Adenosine 5^-Diphosphate (Adp) 9531336 12286829 1648590 790012 5027574 10892040 11710068 10258822 11510747 12493021 5718272 10179977 11182378 9906573 12766594 12843110 Adenosine 5^-Diphosphoribose (Adp-Ribose) 275407 300271 188005 N N 493371 404531 231445 179236 287846 414539 280550 254773 210938 389544 201876 Adenosine 5^-Monophosphate (Amp) 1358271360 1698609664 1487296384 1373227136 1773511168 1944771072 1852851840 1616671360 1268906368 1323820416 1530367360 1266492928 1453279360 1386889856 2027062272 2040829824 Adenosine 5^-Triphosphate (Atp) 2026 1891 1422 2167 2346 2267 2623 2918 2476 2392 2163 2310 2432 2347 2249 2415 Adenylosuccinate 6439360 7365090 3938700 1852273 8131762 8136633 6406470 3302978 3132676 4435854 6590413 5121846 3705869 4869973 9332468 6524800 Adrenate (22:4N6) 294361536 291576640 1330215296 1111936640 823573568 357954752 306612288 1122024576 281097024 342708640 792175488 320960992 366122464 559341504 271864160 301946080 Aica Ribonucleotide 1593562 1789465 1690181 2180476 2104793 1480147 1798537 1966724 1756398 2354102 1367876 1535142 1045348 1320172 1186912 1527910 Alanine 1691586816 1644513664 1715639552 1800366848 1608117120 1476377344 1738949504 1271587584 1751485056 1601183232 1706041216 1657254528 1598109952 1562506880 1755060992 1355588352 Alanylleucine 537978 639347 225105 N 556476 728778 N 94369 273275 524260 1038293 273491 432557 556703 815619 337525 Allantoin 7897199 10653499 7489718 10209051 11644013 10677885 12661322 10686445 8455168 8015659 8575406 7830164 8772449 9844307 8793947 8397272 Alpha-Hydroxyisocaproate 19927 41509 53698 59425 72617 66652 64055 72620 39417 96796 86850 N 56353 106964 85846 135387 Alpha-Hydroxyisovalerate 437279 481611 358891 488307 602067 497914 516888 542922 408077 448537 444244 423882 470431 520615 357253 423101 Alpha-Ketoglutarate 23015714 22388520 18046570 16339311 23773852 21068556 17432648 17672874 24538688 25522088 19935856 18281200 23380126 24444440 18518444 19876808 Alpha-Tocopherol 1209012 19316892 2309420 1135873 847115 1046714 4791534 1731852 1138172 728119 611747 3368129 553747 347011 12706090 18775082 Anserine 56956012 70425192 71924752 72200088 72842216 74297488 78766672 36050880 66746852 73650728 67968112 55707292 57637264 70526232 85779544 70041096 Arabitol/Xylitol 1726704 2191205 2023457 2758345 3144310 1298995 2048049 2875312 2513413 2663875 2368146 2590320 2528578 1329970 5169368 2895023 Arabonate/Xylonate 11584517 12303805 8452724 11420880 14712910 12218547 13455380 10011446 12490435 15875817 11746207 9285887 10979643 13124404 15399545 13140798 Arachidate (20:0) 56837624 54055088 162669600 192664720 205423232 55295852 61775696 216514208 74867712 59802020 153798320 66018416 72750112 102776480 67516048 57148972 Arachidonate (20:4N6) 626348736 659661632 1988490752 1676789632 1660163328 787135616 916277568 1665899520 689822720 742122624 1539716224 780599424 817949568 1276088192 780906496 723221376 Arachidonoyl Ethanolamide 160666 85970 188371 156484 146757 198008 211131 88985 N 174952 123778 136377 124138 109173 162351 N Arginine 1177944064 1175080192 1320288384 1230889216 1158911872 1247855872 1247308544 1211474304 1330867584 1241295872 1288959744 1326032512 1269907200 1353232128 1254368000 1281080704 Argininosuccinate 20550232 19451420 22546400 20541618 17415484 22636516 25024272 22775332 26674264 22465976 21328376 25360452 18548428 23537412 20408062 22220468 Asparagine 443697248 573222080 657019776 574377280 566681600 530274976 497345472 431062112 579558144 532710944 520095264 525601856 465726080 530707776 447852032 477606880 Aspartate 2329031680 2318375424 1960779264 2879962368 2459124224 2218180864 1615474816 2109126144 1745538048 1961968512 1906845568 1932281216 1660257408 1415462400 1502219136 1672989184 Azelate (Nonanedioate) 297905 256827 264549 337857 310271 283742 358045 306965 450633 315831 281606 331908 864748 308822 300733 224980 Behenoyl Sphingomyelin (D18:1/22:0) 170841504 182046912 179067280 170879168 187467984 200352496 172987632 156729232 140696272 196090368 199947920 160328256 195183856 191698000 174444032 181298080 Beta-Alanine 53010672 61580804 70364160 75266192 77042432 50537496 49587956 49421680 83428744 75229456 61607648 64925560 53610712 56006692 52777768 54738000 Beta-Hydroxyisovalerate 325598 317899 343242 362082 368214 354072 363740 312067 196982 250132 362844 335027 302852 402226 316895 404508 Beta-Hydroxyisovaleroylcarnitine 74483784 78288824 94747520 81879712 109208312 81442160 83808056 84511632 105335544 93826128 89435840 79363984 88698592 79860128 87117936 91131808 Beta-Muricholate N 22266 1289295 N 68008 442536 107193 223680 N 43539 343984 N 234996 351364 254730 268926 Beta-Sitosterol 403126 648403 492922 342700 649111 480048 393767 197419 279751 340529 298296 434684 392838 355541 382871 590239 Betaine 587072384 627122496 1061126976 608126848 671708032 669212800 533136640 742326464 699263424 643088320 864346688 619415232 803930304 642499328 838030912 859657792 Betaine Aldehyde 4340599 3832337 5070921 4081682 5331032 4403495 5411104 5731459 5091419 4626028 4553334 5218793 5326677 4904728 4103794 4482878 C-Glycosyltryptophan 5307216 5621003 6249484 6039193 6558579 5985321 5528662 5307465 7093591 7131920 6381316 6022885 6628830 5218861 6360154 6207635 Campesterol 2995074 3308846 2735625 3014748 3421913 3040476 3049119 2283221 2330996 2954217 2811159 2827865 3435107 3183593 2484705 3570242 Caproate (6:0) 728794 712939 775825 N N 630415 872819 727314 739307 612390 790746 1336455 842557 789524 865878 676831 Caprylate (8:0) N 575951 490147 356548 N 325023 622025 576879 N 615709 N N N N 396232 687022 Carnitine 3807066880 3560890880 4061447680 3819027200 4337199616 3794170368 4420890624 4059682048 4202920704 3949907712 3907935744 4071656704 4164849664 4269289984 3989455104 3845713664 Carnosine 3792931 5069847 5508959 4684801 3831117 4172476 4596385 2400600 4304573 5402175 3543021 4572376 3346065 4512285 5174529 4505735 Catechol Sulfate 141354 100408 84619 199925 258279 263014 29222 20376 238430 143764 83224 40860 219061 182574 103118 128049 Cholate N N 2913654 N N 227371 N 56961 N N 164204 N 107104 125474 71011 100880 Cholesterol 150066816 175432912 160966208 144854432 144453664 142671744 156742416 144926416 101771720 150979840 132847376 129514664 157024912 153262672 161059808 165155536 Choline 1241058560 1163025024 1473298560 1200611200 1317599488 1236134144 1326801408 1453490816 1391389952 1300208512 1260152320 1348850688 1297454208 1292048256 1161365376 1273835264 Choline Phosphate 567302016 591254784 713528448 636369664 669878656 595105856 650033728 664322176 675876032 640327872 539137728 590406720 535736480 599864576 522760032 633351040 Citrate 23962760 25821262 25123008 25427936 25684000 23783952 27744608 21998708 20289266 24396176 29287458 22682468 24697744 20785876 18882032 18663880 Citrulline 710124736 746214144 941414272 767432704 847184896 834274432 822212800 786090048 829786176 793116800 829366592 821796864 754897408 784414592 871948096 807857600 Coenzyme A 235992 322254 226413 192412 239422 314013 341523 182720 138169 285475 244078 225910 240082 215391 505441 313606 Corticosterone 98190 147892 173326 220428 172632 255593 108376 248384 97261 30884 214963 48095 216036 157306 70591 162700 Creatine 13128406016 12812792832 12959897600 12861927424 14124668928 12863394816 13991411712 14359101440 14421879808 13418047488 12658611200 13317942272 13174919168 13460034560 12965487616 13579738112 Creatinine 2821040896 3440185600 2897663488 3988951296 4306712064 3633260032 2778093568 3567628800 3540086528 4192460544 4172262656 2746392576 3973365504 2894260992 2455783680 2995010560 Cystathionine 3077277 5087053 2557600 3595684 7002112 3794499 4506247 2616240 3692574 3699913 4595660 3102053 2933190 2942803 4326261 4853429 Cysteine-Glutathione Disulfide 8381246 19156784 16108066 16117297 13933756 13690080 12436460 13347178 18131564 13199791 13874015 12393236 15672018 13860197 9934726 13066717 Cytidine 364095840 413559040 404842272 458698656 462446144 364518912 358327744 443059040 556782528 557407680 386230112 452421216 385119104 401439360 373057632 422815808 Cytidine 5^-Diphosphocholine 511449 457808 471692 555720 553330 511694 357087 468743 456050 447746 601646 446199 665134 607920 476691 435800 Cytidine 5^-Monophosphate (5^-Cmp) 38973000 37955224 42872160 40155128 45627528 38232796 42750952 43972584 43610376 41202300 40888876 39312296 37607872 39842436 45479996 51637336 Cytidine 5^-Monophospho-N-Acetylneuraminic Acid 220510 259016 342211 281609 241645 248354 323332 317239 183122 119297 187121 213157 260751 210788 334728 270429 Cytidine-5^-Diphosphoethanolamine 1149117 1081134 951974 1012182 909840 968806 1248788 1069407 1085913 966815 1088153 1005508 887194 1181715 1197905 1157861 Cytosine 2810150 2091013 2964417 1343686 1505947 1809007 2653691 2234148 2641056 1914244 1631901 2967234 2153552 3016973 2838443 2907231 Decanoylcarnitine 248983 439106 107500 558908 N 418953 403460 257897 215402 208288 N 259234 145710 244642 168332 285273 Dehydroascorbate 14634156 13955066 12538997 13456122 14201622 14030769 12736007 11020851 12540773 15799884 14275711 12621233 12523019 11545123 17991160 13666848 Deoxycarnitine 369170016 343707744 524473344 339330048 381923648 340397312 386313728 393207392 343048864 338928192 324149088 346125984 356972992 391864192 418013312 400122432 Dihomo-Linoleate (20:2N6) 150088992 120765664 556262464 696551104 495434912 159364320 168937600 754880576 197123744 185982592 505783328 185766496 196447904 297336544 169972240 160067584 Dihomo-Linolenate (20:3N3 Or N6) 316610656 265695952 638109376 994011648 754891200 293171744 335963968 1104800384 408846368 434914624 674339328 414762368 355357504 587907776 312952672 297710048 Dihydroxyacetone Phosphate (Dhap) 1717321 2605171 3542046 3246141 4067246 2022992 1941567 2171974 4449462 3345132 1333053 2734103 1615320 1318151 1009363 638954 Dimethylarginine (Sdma + Adma) 51958180 57262272 76609472 61553252 61511184 62036824 74239088 73762880 65598540 63211488 60226300 63835124 52629784 58927028 58347076 67332672 Dimethylglycine 7864228 12138187 18248776 9962420 11290696 11244048 8819718 12251640 13381867 9832183 13666883 8904347 10352981 9318764 9829217 13225293 Docosadienoate (22:2N6) 7888557 8359813 28111218 38370464 30673364 10492951 9609210 35255280 10327374 10483244 25841208 11173398 8532364 14030726 10284687 8505078 Docosahexaenoate (Dha; 22:6N3) 602499328 585455040 1958527360 1626668672 1418033920 657333056 892285440 2076916608 597062080 765101376 1553492736 1005132224 758580992 1208898304 652022528 740197696 Docosapentaenoate (N3 Dpa; 22:5N3) 284447232 229020336 647856960 1194429952 835812160 259493312 305385664 1241528192 294277664 327566816 669827840 366396128 294445440 556883072 217625664 236616928 Docosapentaenoate (N6 Dpa; 22:5N6) 108537256 126803128 1028181504 320344096 266296544 138121216 140928816 373359776 97092552 149142768 365141408 152184624 146283552 252504496 126320576 139767280 Docosatrienoate (22:3N3) 8494182 8944122 27139060 38392088 31401764 9205375 8989666 37632584 13345664 12614180 23851408 13460280 12314162 17110916 10131888 7655773 Dopamine Sulfate (2) 36320 36147 53691 53769 46860 49833 38660 41076 53343 50133 43529 74543 52310 40872 28026 31456 Eicosapentaenoate (Epa; 20:5N3) 29710728 19968086 51306944 118162928 74658800 25317784 53385248 168043808 38842748 40082436 86504432 46565068 30231456 56226396 36130272 30705908 Eicosenoate (20:1) 292723776 235461984 1206144896 1502338048 1176279808 358480000 360179360 1652037760 445468672 387165056 848254272 376400576 398476160 635348224 391892608 346195040 Ergothioneine 13678734 12876496 12095790 6851197 10177392 9885618 20498164 9222568 10027578 11847627 13489726 8438781 12695574 15941842 29055364 13430191 Erucate (22:1N9) 51379032 53927296 170732384 267389008 187425792 59454428 56681756 240826720 59008116 65526432 149119248 49258212 71390608 96454072 65441200 60284376 Erythronate 19187200 18875550 19046440 25888248 22764004 24479356 17625274 18910622 24637706 24720272 22100036 20136054 23717552 24266724 20658300 20553154 Ethylmalonate 3456857 3326944 1996363 1906701 1903886 3743016 4719736 4283996 3426047 3373813 1490913 3401113 2058673 3568774 3388061 3824767 Flavin Adenine Dinucleotide (Fad) 7401284 8089268 7720351 7253197 8007227 8781862 8865746 7863519 6936405 7661155 7325629 8541827 8334539 8774770 9185499 8818128 Flavin Mononucleotide (Fmn) 235236 301836 283170 244770 267276 348438 344434 282694 233793 263634 266822 286063 255391 255287 330956 307959 Fructose 956381 616586 1226678 2960108 2508715 1148173 996322 1202767 2452965 2268783 797145 1479243 2307383 1434768 400387 1219065 Fructose-6-Phosphate 5702945 5322284 12226735 62821024 53985088 10239449 12621023 22795184 40725640 27261632 5680880 18702440 28509164 12479833 8235187 37349584 Fumarate 118926168 107151512 112251744 111634088 100849736 119761968 136579296 123288568 115769760 107445368 104302648 112669840 112893312 120339064 126308304 106371960 Galactitol (Dulcitol) 867542 779231 935951 807094 859317 758784 810711 978961 794430 728422 851176 655203 756389 738097 762574 635048 Galactonate 11187832 10293868 12474529 13436768 12021251 10635038 10542374 10414917 13939168 12182245 9276465 11325308 13339293 9678670 13271867 12327671 Gamma-Aminobutyrate (Gaba) 391528224 339185376 335073408 365021440 315920640 354936224 263542528 314122080 427502912 367610400 315823776 401520640 371104160 377236800 279961216 298597920 Gamma-Glutamyl-Epsilon-Lysine 2742931 4795229 2743423 2645848 4179213 3920335 3858487 3088448 3150949 2746734 3830858 2590532 2744893 2724834 3557009 3721357 Gamma-Glutamylglutamine 3751967 11189237 959413 936365 875358 2021723 1097357 2304226 2625249 1629302 1008931 2213606 1438718 1288701 5694918 5462230 Gamma-Glutamylhistidine 707202 1609297 1066307 646908 705531 721185 715005 526908 770204 916336 988356 837100 756998 457290 1199362 1167324 Gamma-Glutamylisoleucine 451843 1098082 400338 304476 456174 411690 488094 480444 342697 458785 603569 337410 526048 314547 755481 653464 Gamma-Glutamylleucine 3710061 6203822 3039867 3232691 3459602 3137258 2846026 3383744 3236779 3502497 4465930 2961774 4127190 3080599 4038878 4285536 Gamma-Glutamylphenylalanine 751632 1661866 834001 610839 466639 675934 341915 630900 558115 582090 925288 507940 851280 469552 992476 916148 Gamma-Glutamylthreonine 1026086 1618957 1021124 925652 1437828 1042605 1302130 1023598 1200298 1060691 1388611 1349429 1405429 1120407 1255564 1201089 Gamma-Glutamylvaline 3131566 5743872 2460935 2431843 3465905 2972921 2707427 3021396 2689878 2933211 3612520 2469330 3251141 2593333 3676954 3880996 Gluconate 1676030 1194031 1405728 1823773 1589734 1485157 1453770 1193954 2332510 2059399 1153699 1919971 1757891 1284150 1607595 1553963 Glucosamine-6-Phosphate 7002574 7873392 13410542 51003648 63863436 14033750 14818241 22041454 57410808 38670848 7443944 24559198 34872820 17361060 11460442 38045804 Glucose 88997072 57212516 97161936 129872488 122267536 94839216 99511688 101360080 103010256 94109672 56234160 98505776 100481392 68072776 98679344 98038152 Glucose 6-Phosphate 6253497 7268239 11623518 42751616 55197568 10812348 13192710 20968652 43512148 33225892 5971153 20443508 26112756 13261801 9946796 32783330 Glucuronate 329945 175182 178624 365511 351505 379219 142203 270085 669702 430875 386266 306438 470087 405898 102708 251098 Glutamate 8033048064 8424397312 8460972032 9033657344 10289395712 9700586496 8096534528 9473050624 9160181760 9301008384 8761645056 8672854016 9711029248 8895362048 8088064512 9450561536 Glutamate- Gamma-Methyl Ester 32559788 34695572 41272552 33576712 27404858 36138140 33806748 30176518 29707312 31574046 44512792 31610296 28268432 31267396 32139478 30134980 Glutamine 7858759680 8527996928 9409219584 8330080256 8869105664 8311501824 8614663168 8049025536 8803189760 8478594048 8558331392 8019758592 8224182784 8525798400 8365633024 8865218560 Glutarate (Pentanedioate) 3222353 3563453 3266518 3754927 4159836 4280991 3274805 2869684 3165424 3173153 3184309 3134268 3573517 4081293 2921360 3342041 Glutarylcarnitine (C5) 4231902 3638944 4161230 3603119 3347897 3986743 2693810 2073083 5820733 3854478 4506417 4075831 5216508 4328343 2110773 2183641 Glutathione- Oxidized (Gssg) 674162432 656934272 698153280 706273344 720239488 727824128 744135360 753759296 758443584 757564608 730254272 657338944 699002304 752486272 790679936 745218304 Glutathione- Reduced (Gsh) 1398742 1935740 1312853 1000101 1583369 1839103 2283080 1261905 788077 1393986 1151535 1019888 1150345 1377285 3503595 2038191 Glycerate 50221984 51719032 57219872 57338208 58930680 54281736 53297344 56391940 55314408 54961840 54575760 54869248 57372092 56537040 61726984 54386344 Glycerol 2389564 1630829 2191739 3002420 2170550 2250894 2967318 2525976 3431480 3365792 2511323 3181080 3342202 2636919 2390380 2586372 Glycerol 3-Phosphate 9502818 6395846 8368569 7525518 7887467 8395591 15909663 21128764 12432351 12768884 6706996 10699270 9157397 8456087 16944170 15722599 Glycerophosphoethanolamine 2086766 2131773 2195458 2231558 2560615 2762667 2642667 2765510 2426462 2476407 2880021 2554183 2890179 2434817 2425383 2608646 Glycerophosphoglycerol 9260344 10033108 11463505 10275668 11847284 12027883 13197723 13685439 9698190 10735884 11631561 12531657 14447216 11531933 12287577 12856060 Glycerophosphoinositol 1600602 1981452 2035005 1733459 2064722 1849869 1364209 1653260 1422250 1744404 1861114 1590593 1836600 1508282 1449625 1519817 Glycerophosphorylcholine (Gpc) 581436032 646201408 539555520 525319264 555727296 637842688 567972224 683000128 520699328 553575040 577653824 608586496 592958784 574959616 623468480 643807296 Glycine 172799904 213568080 238576592 197720880 199561840 190420224 194598640 187754112 208443568 201875136 212844720 187843392 191375648 192924816 205026848 199059680 Glycosyl-N-Palmitoyl-Sphingosine 928534 2106463 1819480 1498887 1117001 1383022 908818 1080457 1232164 1129722 1295461 1256149 1179489 1202970 417548 1655990 Glycosyl-N-Stearoyl-Sphingosine 110254 342571 242811 180529 268381 244023 273922 162553 N 224957 262876 N 286500 N 243422 251818 Glycylisoleucine N N N 251562 N 357183 140478 192565 158630 221804 247530 N 175406 328667 202949 405614 Glycylleucine 2253909 1962751 2212368 1983706 2704184 2583871 2262855 1912160 1900444 2599449 3019315 1940539 2434555 2404605 3144474 2368284 Glycylvaline 1826332 1825014 2116559 1904090 2395280 2110040 2011290 1989952 1848635 2300210 2452207 1899201 2464839 2158944 2749010 2371861 Guanidinoacetate 129482 110090 201278 130302 99412 145667 113852 104601 159933 152850 120606 141992 132049 160698 116588 118121 Guanidinosuccinate 574463 1107367 N 290864 195413 340203 227736 155212 360329 246351 102494 500678 133551 178238 371472 266031 Guanine 5931631 4319462 6367884 4928020 4350683 4361900 6267988 6766283 6728307 4158799 4364300 6827409 5466150 7300722 5546021 5105592 Guanosine 24937412 32567896 5216164 49637004 6245094 36228740 3831047 9032332 5334191 26500548 21232696 7820716 7017284 6289351 21295962 31718752 Guanosine 5^- Monophosphate (5^-Gmp) 105548288 112508616 124755992 103418008 145243792 124512000 133036464 124401056 115463776 114501696 120121576 107655136 107463752 113878376 131955288 139602496 Gulonic Acid 8593840 7888912 6531471 7667885 5964748 7091017 8181357 6870259 9839139 10592114 7702746 6982928 8205882 6416271 11542682 8145497 Hexanoylglycine 240423 283279 140631 141385 154730 659567 360430 647065 294829 333242 122536 209742 87547 150744 180068 382574 Hippurate 24750 N N 31062 31689 28247 N N N 33693 N N 25975 N 18009 21122 Histamine 186545 215980 N 251136 847591 261092 311503 536326 813687 492205 1023042 N 463662 526014 1830517 1120113 Histidine 17633752 17707172 31272282 19902168 19329384 19547786 20157692 16905832 21521336 19912192 25269568 22842132 25052784 21239364 21389618 21740054 Homoarginine 8347823 9286734 10597485 10149434 9001271 9764552 8327212 12632567 10607806 10314425 7904435 9902193 10477789 7889505 9388502 9083143 Homoserine 540993 750275 529520 1553631 2084888 1298799 610716 675588 540261 662808 568635 654982 623437 593854 919831 818082 Homostachydrine 671804 1133387 1016905 970626 1368740 1665727 1002530 1178888 947099 1091226 1342016 1486098 1455477 1299496 1563788 1705934 Hypotaurine 4217931 3514307 8173279 3613452 3710989 3897526 4695436 3853545 3529286 3031843 3669353 3324741 4131089 4325241 4659939 4433388 Hypoxanthine 79702544 77091592 80850576 84418424 65136860 70020632 67098532 74064272 78123792 76688848 84268840 83207360 81406624 84693216 63745160 66678920 Imidazole Lactate 4120743 5244727 4177037 5160554 4238863 5712862 5234321 3243314 4012853 4669072 4678726 5628295 4156922 5175123 6611443 6780075 Imidazole Propionate 197468 276863 N 289973 419502 854938 N 481500 311207 264923 406061 294208 251575 498825 346763 284669 Indolelactate 465054 1132194 361272 409717 518849 380619 331831 279951 405697 409425 163133 229511 450109 221610 1013279 841534 Indolepropionate 25175 39536 68708 47589 47166 48389 43680 N 69001 62456 53672 31328 80470 61124 88717 294865 Inosine 335433184 327946272 329590848 379167840 333848704 322277408 305812800 341924384 388069536 364332960 330240160 368729152 362852352 375708128 283346688 307173888 Inosine 5^-Monophosphate (Imp) 39683716 39500680 47158696 34295336 45030128 41103384 45964076 41611748 40315748 40956752 35029336 38670092 37142584 38634336 48719180 51833936 Inositol 1-Phosphate (I1P) 320192 337169 343640 440607 337566 458980 421129 622528 435865 390119 362164 414318 528996 458510 386093 506065 Isobar: Fructose 1-6-Diphosphate- Glucose 1-6-Diphosphate- Myo-Inositol 1-4 Or 1-3-Diphosphate 5280725 4590030 6327262 5318472 6685352 4686195 4470791 4081858 8095677 8280161 5874770 5882825 7333727 5625810 5450134 5906190 Isobutyrylcarnitine 6602739 7558858 6001028 2827186 2387719 5884159 10733169 7742251 5318141 5234396 2847402 5255801 3222295 5572772 9442364 6454115 Isocitrate 1898307 1513793 2238308 1613159 1695472 1809613 1981483 2046895 1817598 2017606 2125401 1958977 1955157 2205772 1519620 1318729 Isoleucine 1195979904 1357636864 1136179456 1088487936 1075281408 1091984384 1293773952 1246182784 1320026368 1293422336 1201857536 1278637312 1165051776 1223951616 1172136192 1136759296 Isoleucylglycine 5273731 5850649 6840608 5692492 7990479 6154535 6207570 5519525 5998017 6486192 9032552 5364600 7942066 6405280 7428226 6022737 Isovalerylglycine 154296 187000 80429 248189 279963 272954 152830 174917 220912 192710 316025 164034 207384 207981 269343 201864 Kynurenine 3497718 4581788 4605340 3314182 4470239 3852549 5067210 5435252 3908439 3920325 4778422 3245269 3618269 3400804 4182898 4550091 Lactate 160303840 169285120 157724160 175090736 206264400 165055632 164173536 139248336 187957056 218422976 261332800 174094464 236542448 194441408 163601216 142035808 Laurylcarnitine 464103 597618 275792 481926 209397 455642 466987 406830 418878 389006 193476 414033 312804 388838 332224 666025 Leucine 1059571392 1079121408 1114760832 1128202496 1122032000 926275968 1061363392 1037413760 1360293504 1212256384 1209641856 1175664384 1405720448 1179220096 1113484800 987208320 Leucylalanine 818120 716463 655803 484253 979385 862919 665576 533161 1018372 723503 1185935 690977 1069005 868217 1120596 906803 Leucylglutamine 209514 300282 156885 205290 242871 401494 185521 137097 178547 222490 387616 189234 267176 285459 273910 253076 Leucylglycine 2400546 2559658 2283489 1535126 3349047 2724369 1973658 1428438 1965032 2345232 3837591 1861854 2342012 2325919 3112397 2329637 Linoleamide (18:2N6) 2079427 651993 938815 12642810 1198391 605493 5133024 28543866 1389775 2158153 1657813 483156 2424539 1903010 1933800 6012844 Linoleate (18:2N6) 2777083392 2375841536 6260062720 7219940864 6592588288 2626740992 4319780352 7839259648 4352093696 3566754304 5959056384 3611042816 3669906432 4854232064 3640896768 3232073984 Linolenate [Alpha Or Gamma; (18:3N3 Or 6)] 138819616 79613024 420883040 642951616 519501824 120077120 181359632 563834496 266552848 173744272 477463456 172319360 220383344 271884832 175774048 138519888 Linoleoylcarnitine 1137480 2808665 1089466 1452797 988030 1235849 916107 1015691 1352120 1123017 815459 1194447 841324 784038 808655 3030082 Lysine 1285001600 1521997568 1441573632 1401888256 1391099008 1413418368 1558022144 1325203200 1354875648 1458379136 1538966144 1484339968 1395165568 1491979648 1453347968 1513134592 Malate 730376064 653212864 667942656 616403200 637834752 720040832 784563456 710453376 712567808 678053376 647442368 716694272 680714176 698754880 717753664 663291136 Maleate 2025901 1118513 1067408 1771482 1012063 1402240 1617965 1407607 1089668 1495263 1579488 1006772 1289365 1580780 1231681 1270375 Malonyl Coa 97811 105400 83364 91143 98082 103102 113789 74158 115174 115293 110675 106404 110767 95664 100459 110008 Malonylcarnitine 111500064 98605232 107034728 111685184 125538560 113738128 116236496 115724056 117019584 120237648 117411240 110925696 109764512 116634696 119243864 119272816 Maltose 1426124 1502719 1705723 3160597 3504064 1332773 1901058 1706053 3634969 2228158 1356787 1806080 2326625 1610019 1496583 2455334 Maltotetraose 395686 487476 611121 1701591 1947555 412380 487291 742184 2846959 1433303 274849 710661 977677 479176 534757 1465416 Maltotriose 3372694 1796914 4354159 10683589 11553118 3173515 4093294 4366015 15124098 9240606 2688396 5328896 7217946 3612007 3748109 7990235 Mannitol/Sorbitol 3695134 3529196 4088716 6136951 5989614 3775099 4083909 3573687 3411225 4356339 6711491 3157715 4152659 3473049 3454526 3243670 Mannose 823601 550692 749847 2006339 2061985 1039743 1056494 1218372 1967016 1483618 646233 1042900 1325520 910204 650067 1052033 Mannose-6-Phosphate 2458727 2485510 4030863 14733304 18512776 3879421 4546650 6496569 17520024 11083664 2182817 7689263 10293227 4784034 3762499 10498689 Margarate (17:0) 63337620 54068388 239428240 223945152 211172784 62082716 82684520 236786816 82779272 63892080 222824400 76460000 82459144 125863376 72829992 70997144 Mead Acid (20:3N9) 43312792 39110904 154692512 158267136 95669144 43789568 55340556 111258768 48719892 54675140 113982736 47312836 45764124 59628516 52661192 45305336 Methionine 236999968 325732544 348728064 244153728 244996464 231881072 215486512 145310128 268988960 231637024 277932288 228819424 286303520 260709504 331350624 228469808 Methionine Sulfone 240649 290991 249226 178648 179962 219822 229819 262876 234919 253155 297088 320460 198852 189319 225324 201583 Methionine Sulfoxide 226411984 265119328 377731200 343454720 347690176 257819920 202088880 230290592 345453504 331468320 348455040 275239168 357086784 265200336 211355984 236276384 Methyl Glucopyranoside (Alpha + Beta) 48284 58541 51691 59055 65931 68142 57691 43742 46612 47164 78056 57831 51725 34730 80627 64120 Methylmalonate (Mma) 62443728 53132136 66013484 56172396 63480680 59315388 46537080 44813680 65975120 64511508 57103504 55963268 65625568 61442464 48884068 58005764 Methylphosphate 418623 466545 486254 578612 463649 522108 469528 472093 448399 494183 536125 479113 413732 447623 546308 591263 Methylsuccinate 2969499 2709310 2529125 2268937 2232289 3181066 3481489 3622774 2674721 2922435 2094811 3060243 2656026 3216919 3109566 3067549 Myo-Inositol 11763311 11878727 10175101 11645556 12183539 12453566 14389025 13854988 12520787 11755547 12827153 11649071 13018797 11518867 13297583 13918831 Myristate (14:0) 170829152 127889200 415055872 450729504 397364864 172952528 184627968 358381408 197679488 161545840 461829632 169669424 198588672 276453792 179569200 172819280 Myristoleate (14:1N5) 13185604 9973543 8456680 13254464 10481558 15935123 14492309 16350886 14346671 10332234 12465172 11193514 12315130 14795586 10927102 10115542 Myristoylcarnitine 1177556 2575563 715698 1034302 414939 1407527 1482266 924121 1074612 903339 586426 1256105 496940 864261 614135 2490519 N-Acetyl-Aspartyl-Glutamate (Naag) 68352 77049 26584 96677 101713 53532 65623 72694 90344 79801 69807 54582 66134 48856 55167 59003 N-Acetylalanine 616065 601397 706306 762484 687428 656932 604151 661563 752717 733545 750234 817090 780808 724288 604607 651471 N-Acetylarginine 908347 1339508 954048 881021 769164 944077 930009 1035753 831433 957952 942060 1000138 689354 907582 1120081 1093600 N-Acetylasparagine 12875809 13294853 14500902 12647025 12601024 12251485 13505756 12654427 13271431 12882552 12255662 13297939 12232612 12389488 12124767 12937282 N-Acetylaspartate (Naa) 723733 428307 514578 532202 523902 952698 469943 503920 701931 598089 1457389 505953 1090202 2125695 487073 502829 N-Acetylglucosamine 6-Phosphate 227183 222152 258197 256471 157068 239689 216578 267588 218222 229171 204052 265574 187359 190135 215873 200338 N-Acetylglucosaminylasparagine 1044070 854741 1141195 1081259 1037839 985298 1056401 1006339 1202499 1136354 1123362 978616 920035 1020521 1046850 975213 N-Acetylglutamate 1550824 846528 1268083 1207638 1492555 979202 1097373 1180599 1510039 1783533 1677756 1425563 1353486 1258314 1178364 811512 N-Acetylglutamine 5696226 8947154 5192549 5961256 4292690 6036181 5412898 4991802 5667671 4384606 4587682 5037405 4237508 4815689 6260714 7244216 N-Acetylglycine 71630 133332 164302 196139 154563 206888 149112 306773 165254 143533 212904 129583 156048 100218 135355 198537 N-Acetylhistamine N N N N N 312903 N N N N N N N N 526636 6010758 N-Acetylhistidine 1409322 2439582 2465669 1276339 999330 1470196 1477831 1270270 1526481 1378874 1770745 1583370 1532356 1075213 1948953 1938320 N-Acetylleucine 94433 79818 109328 128601 141487 75638 75033 85894 142015 113825 195596 85143 172601 92527 101247 87067 N-Acetylmethionine 398250 320838 523200 410755 437906 465747 473504 491176 529116 516793 532019 418974 436147 454462 416926 416303 N-Acetylmethionine Sulfoxide 43778 52318 58231 56919 36555 39231 38800 43732 91330 76912 54184 48323 81996 39867 38330 32924 N-Acetylneuraminate 960881 1020110 1139561 1024135 1081238 919924 746768 784455 1222211 1117952 945970 896475 1092312 1039645 792261 689384 N-Acetylphenylalanine 54610 56030 91562 58003 57531 58192 71876 74130 89250 72181 66593 63688 99709 63721 64452 66070 N-Acetylserine 8188858 7986352 9159676 7765487 8152071 7116795 7927849 9854631 8873186 8403667 7390672 8907753 7168112 7513837 8777966 8042159 N-Acetyltaurine 28766698 22756048 22403556 35291640 17451194 28200416 26728744 28707470 18583300 27633134 25938616 20798666 24434054 26494666 22017920 25733650 N-Acetylthreonine 928135 919344 967232 991720 1020282 994830 953382 1020203 1027277 1113420 1107038 1245065 1067617 1064553 1027872 1051672 N-Alpha-Acetylornithine 475281 728978 485549 503076 545814 423562 851024 750306 754433 656236 945984 573988 638589 572158 479792 813990 N-Delta-Acetylornithine 8179354 13308047 6145163 7177461 7482443 12195467 9309282 7671786 5808802 6900975 10919587 5346810 6683208 8295122 13282423 10388504 N-Formylmethionine 937438 1095754 916189 997559 956448 1070961 1043551 829323 958461 1155503 1058150 946842 944711 922318 1118136 1095721 N-Formylphenylalanine 96630 102319 111196 82241 70920 85769 107011 138404 157328 119902 94993 114097 142470 104915 97132 90416 N-Glycolylneuraminate 12692476 12509138 9492249 9685067 14267314 11277278 12841125 12656965 14772480 15111899 13193860 9217067 11925376 10770931 10723712 11233773 N-Methylproline 2735673 3401241 2687252 1711246 2721186 3519006 1828067 1812049 2828012 1989945 3292451 2111954 3078110 2821058 2917362 1481913 N-Monomethylarginine 6384640 7782089 12831784 7876200 9283796 8424977 9224271 9294602 8105433 10366976 7725000 8438896 7953692 9056962 9137679 9745323 N-Oleoyltaurine 1901846 1748842 5388473 6279638 4682115 1598296 3435941 8183593 1711858 1879292 4652430 1769285 1610420 2848970 1885950 1727555 N-Palmitoyl-Sphinganine (D18:0/16:0) 1858023 1730376 2550933 2425252 2250752 2126321 1513442 1920316 1937592 2097498 2269014 1664573 2777249 2761211 1363344 1606535 N-Palmitoyl-Sphingosine (D18:1/16:0) 41614696 36160304 56658480 49859244 45695500 47301760 38637880 43185008 41634376 48905716 47496432 41733576 56641072 59123996 31804418 35803560 N-Palmitoyltaurine 2212248 1928906 7020107 7624736 5848566 2130563 3491475 13929711 1938332 2044970 5256305 1482714 1654906 3638385 1979511 2071674 N-Stearoyltaurine 2850898 2539389 15503577 12888883 12104131 2722644 5342784 15343517 3102474 2658069 10733900 3307786 2798056 6260585 2668776 3124062 N1-Methyl-2-Pyridone-5-Carboxamide 6981014 12658989 9020258 6132001 4970735 5195335 14224470 13388682 9796202 12411691 7518171 10142148 4541409 6222871 9173818 10199954 N1-Methyladenosine 4275816 4519017 4286492 4546849 4741484 4190503 5087358 4633997 5204331 5127355 4584610 4355455 2837800 3142991 3410547 4107773 N2-N2-Dimethylguanosine N 230728 243445 196053 176119 N 305100 N 303255 232617 174475 251727 156650 162859 159031 N N4-Acetylcytidine 101164 99307 106980 157044 176559 102992 162342 98558 167796 153656 152297 114609 N 49227 142664 181642 N6-N6-N6-Trimethyllysine 83382256 95741744 100736800 77328728 95411880 91974568 110832288 104846272 89811760 91796224 111596352 109568512 112898080 110774256 99536952 96172880 N6-Acetyllysine 98420 156444 89321 90035 99716 132241 143131 109917 107329 134652 100255 131126 117432 108790 120927 150443 N6-Carboxyethyllysine 13102621 13387408 12845008 10456898 13288867 13687254 17615608 13825404 13095627 13513460 13745015 13801129 14065402 14440613 17183168 14752471 N6-Carboxymethyllysine 150950016 91797352 185002656 112339928 173271136 102289352 187643280 188939680 172752288 168227536 189229648 188617296 175999392 182874960 126991368 115056464 N6-Succinyladenosine 7428035 5024544 3295892 4287953 3064982 7237151 5382630 3620615 3218074 6063954 7133453 4120106 3364547 3554005 7136871 5149317 Nicotinamide 2683474432 2691494400 2158799360 2781582848 2229599232 2830827008 2160361472 2119646080 2124904960 2595325696 2524864768 2065760896 2246045184 2191828736 2826334464 2813381120 Nicotinamide Adenine Dinucleotide (Nad+) 227509 259716 268025 204517 201474 243198 242758 217347 205715 245230 250594 257755 261188 253827 256875 250681 Nicotinamide Ribonucleotide (Nmn) 509679 423504 352866 240670 410195 630239 1270636 494512 297797 349141 367069 348031 316835 467814 1754372 1334211 Nicotinamide Riboside 844859 676844 366953 606202 705885 1291045 1064514 581945 667792 964175 716171 651638 487846 883791 939881 821238 Nonadecanoate (19:0) 24135584 20927636 93973856 100166352 86039672 22831500 33370266 109852880 27295828 24966456 73548616 29556786 22813612 37577600 25388964 26480502 Oleamide 8661317 3364850 2833111 58580784 4319832 2710182 20130820 132457928 5108384 10229449 6358989 1257842 12907892 7667568 8923847 29627392 Oleate/Vaccenate (18:1) 2798185984 2013832832 5898397696 7541292032 5844598784 2560882432 4499459584 7380605952 4085334528 3272438528 6549416448 3670712064 3378224384 4595817984 3419597824 2896989184 Oleoyl Ethanolamide 4277322 3618061 20375132 13549232 12439391 3739646 5745519 16355547 4118811 3856344 12415657 4438514 3351258 6482554 3662217 4296425 Oleoylcarnitine 3028133 9061254 2254045 3128072 1656939 3304105 2639276 2268499 2580314 2847863 1733868 3726500 1596169 1861051 1898903 9838355 Ophthalmate 2061878 2800678 3508625 2413350 3292564 1984390 3172545 2668448 3264696 2710289 3014630 2285603 2557766 2414493 2323989 3291176 Ornithine 57541900 101990656 93001320 80106552 60279968 50744448 45578268 51916328 62292248 71567376 81727704 50888728 73958296 55291232 78016904 70195472 Orotate 2761962 2916531 3702840 4312928 3559158 3356804 3568131 3765339 2971002 3136994 3053729 2885226 3417360 3173097 2754394 2712190 Orotidine 1825249 2010488 1790710 2010329 1975660 2101018 2320765 2074371 2203809 1896100 1898930 1606428 2108279 2408728 1817381 1861710 P-Cresol Sulfate N N N N N 392340 909099 N N N 511373 N 670246 26145 1123717 40849 Palmitate (16:0) 2479848192 1976049280 5910657024 6076331008 5820393984 2279059712 3457133056 5614498304 3261829120 2720088064 5729438720 2915234560 2922718464 3953082112 2793148160 2659876864 Palmitoleate (16:1N7) 344158880 141867120 614859328 1098674176 735469504 300748288 376960640 767184384 443385824 311076768 1071760512 321889152 433943680 528443200 301999776 255350992 Palmitoyl Dihydrosphingomyelin (D18:0/16:0) 14675656 15775138 18476684 15991387 17930816 15871059 15087900 18498084 15225194 17026584 16504579 14787359 17829948 19266440 14801881 14911182 Palmitoyl Ethanolamide 4051212 3725191 22457680 15938101 14535184 3991806 4992327 18063702 4674202 4227141 12098491 4344284 3733513 6944968 3485610 3916347 Palmitoyl Sphingomyelin (D18:1/16:0) 2763981 2331951 2632531 2860568 3355731 2531673 2516548 2445867 3186169 2358304 4044647 2292563 2509227 2661749 3421369 2711226 Palmitoylcarnitine 6316169 13700580 4198105 5433848 4294521 8119352 5330743 5207708 5483889 6093486 3785013 5754579 3240777 3821317 3486214 13150025 Palmitoylcholine 7359794 10489548 12833967 8014570 6824227 8377783 8102449 7342312 4109869 7047820 7082409 6257243 6044661 7136600 6346272 9284913 Pantothenate 74741016 77611088 65546628 87464368 73540656 76473792 72164784 75181928 80283344 73159768 69361232 84235768 78551560 84360048 68491400 69296112 Pentadecanoate (15:0) 54219276 55232648 118394184 86893216 114184712 59932320 63897404 103928176 56801160 50076928 103443952 62279256 63255836 80845088 57755696 58088920 Phenol Sulfate 1177861 961402 1095158 1923142 3560185 5152454 936811 1229247 1543591 729456 897243 639008 2446224 4466051 1616402 2935681 Phenylacetylglycine 3566226 3764204 1041013 4674729 5560389 13939669 3077746 3687378 2478835 1940137 3040816 2450334 6503790 8296931 6314698 11380843 Phenylalanine 1202059392 1273380736 1597007232 1285000320 1179417216 1192556288 1160562048 1204578688 1399556480 1359974272 1354348928 1224424960 1410529664 1291480832 1212564224 1180101760 Phenylalanylalanine 1031968 810508 650719 771525 1121273 980513 791351 680287 1143675 1158852 1572367 863898 1274273 1062233 1327837 986305 Phenylalanylglycine 1039812 1129481 1601460 1433601 1452269 1194931 899361 1133450 1158811 1565825 1728246 1100813 1224182 1060954 1288030 1017353 Phenyllactate (Pla) 47004 37493 67842 68964 92749 46560 56224 48999 75408 75856 65504 41332 80652 84664 61002 42898 Phosphate 266200240 254712832 259446960 228357152 207631552 257487424 260991936 261015744 210991216 231307440 269953728 246338784 247529904 267554224 258978688 242437616 Phosphoenolpyruvate (Pep) 3315668 2941726 3827610 2981631 5358347 2959974 2486300 2354859 4450811 4325027 4149957 3258862 3222736 4005706 3179774 2058156 Phosphoethanolamine 6540964 5493311 7533115 5966972 5654215 5434782 7303704 8681235 7340451 7599376 6291995 8538953 5584398 6730090 6253699 8212462 Phosphopantetheine 404926 440059 447224 260251 405552 498144 637280 355855 194746 334549 314955 288423 259485 344144 1059658 515428 Phytosphingosine 266794 278524 362405 241219 245218 248729 291867 248173 258408 294373 311923 272577 316716 230136 334939 263914 Pipecolate 98207232 136442240 76509632 124375576 129204904 125833800 121061560 99598240 111400624 106274984 114255104 91626344 93850480 116575968 168813248 1530882304 Pro-Hydroxy-Pro 3034339 5354379 2882169 2561376 2383654 2959948 2464897 3196059 3077054 2442346 2897779 3031175 2212197 2055630 3861854 3781995 Proline 904889600 1200432896 1393059712 1491499776 1236305920 900700160 854720960 947124928 1192460288 1130754688 1316906112 1040487104 1344683008 1042480064 1062539520 1047756864 Prolylglutamine 2183388 2306729 1815123 1796758 2584954 2066436 4118870 2636502 2342768 1394364 2456970 2220839 2114864 2056094 3363066 3370223 Prolylglycine 9008700 11749108 11550126 10105261 9161377 10439592 19157628 14543792 11552190 15292492 12809755 14330404 10514045 12374683 12126208 14720611 Propionylcarnitine 179968720 213832992 177187456 193196336 249428960 258545600 204914368 217599376 209244368 243675616 326869408 200466288 303780160 250683568 208452864 201157488 Pseudouridine 2511284 3648321 2655744 3084026 3449474 2920587 3691260 3589742 2749110 2887880 2989983 2799488 2157544 2479780 3156583 3239955 Pterin 28354 24584 25646 26091 31045 30418 26164 20107 25508 28080 29632 27267 28706 22068 N 20404 Putrescine 1017474 852410 1679734 1109235 1678359 1444742 1155600 1304596 1710169 1621338 1316223 1280487 985569 1104349 1172409 1146380 Pyridoxal 388873 661725 677934 565361 685588 345841 380652 365092 636069 644521 374353 413894 280601 356696 616735 546522 Pyridoxal Phosphate 881814 728517 733589 730745 682433 866818 861764 830885 860041 753010 675029 916198 952325 885268 952625 901425 Pyridoxamine Phosphate 4216831 4464204 2740699 3282711 3313033 4469944 3226651 2823062 2605040 3817623 3502849 2760721 3223156 2729969 4877471 3503048 Pyridoxate 59726 41869 130133 89377 142123 113126 60943 67933 76528 137503 146832 245248 159024 124884 122359 156917 Pyroglutamine 7508875 7046776 8175517 9108604 8000123 7338199 7977944 8570987 7603108 8936490 7783846 6754389 6256552 7532058 6748116 7076977 Pyrraline 157091 174638 248611 151353 283394 251205 185211 132369 456446 224195 171127 N N 85137 162913 261777 Pyruvate 25366042 21995826 23030978 26384104 23163494 24779486 23285704 25035972 20334820 19330454 17144392 14099500 16626210 15628334 19982710 16008672 Retinol (Vitamin A) 258902 3098419 273982 696195 N 348474 N 255903 264527 N N 1038013 N N N 3581807 Ribitol 411468 496661 429092 526078 482830 417439 469271 447208 429111 390097 361697 408318 422859 492976 334897 367456 Riboflavin (Vitamin B2) 951008 889499 1051143 1146851 1000182 1416313 1166208 1260352 673876 839255 856679 1129784 874887 1169410 1073642 1277720 Ribonate 3926374 3626442 3146001 3353850 3925275 3654007 3459188 2903022 4658526 5090883 3604889 3121312 3819300 4456693 3280226 3247542 Ribose 1251177 1437143 1940258 2105936 1717030 1228087 1004353 1442569 2120038 1672731 1114888 1579197 1669924 1475911 452908 938917 Ribose 1-Phosphate 17877392 17483536 20448012 33294056 20174468 20856828 23717370 33261312 24762940 23440794 15726331 22586180 24593936 23760432 20212178 23278684 Ribulose/Xylulose 1221388 1326545 1633081 1486151 1015515 1124218 722954 1039733 1177517 997778 941970 1270137 1243335 1305145 538856 806420 S-Adenosylhomocysteine (Sah) 2825323 2797386 2584520 2352407 2181659 2695929 2677422 2686859 2967729 2847882 2262658 2514893 2946013 2827047 2888419 2863064 S-Adenosylmethionine (Sam) 16027982 16883912 16964292 18930872 17425640 17777972 15754017 14306605 15420604 17572120 18900414 14939273 16740455 15531664 16411305 16479304 S-Lactoylglutathione 1254375 1336648 1516172 1873934 2152685 1789058 1477861 1578687 1541153 1796395 1830684 1685370 1769764 1570018 1480508 1748443 S-Methylcysteine 2045020 1778499 1749321 1555921 1447365 1112655 1823679 2297531 1469560 1958350 1680273 1453152 1456759 1301717 1706030 1506467 S-Methylglutathione 816618 825190 872042 930272 907763 870332 831295 664330 898475 962969 932351 712482 893993 896271 912617 693115 Sarcosine (N-Methylglycine) 1622549 N 1967875 1373189 2457544 1406076 1432318 926564 1589375 1830233 2658975 1349373 1452584 1770746 1429288 2237777 Sedoheptulose-7-Phosphate 3282481 3654899 3578037 7579236 7494251 3710435 3422763 4685686 8067932 6274934 3006178 5167355 5745305 4763111 2877898 5269598 Serine 431663424 514569056 574135360 618046464 572783936 544166912 452446080 463388416 641932224 583051840 584866816 532691968 536290368 534642272 562445440 543327872 Spermidine 11772733 12097557 11243915 20709280 6892454 8890736 6881133 9215162 27879948 6734978 10749575 15970962 7058639 6827452 6532138 7553083 Sphinganine 1864418 1744704 2091212 2087460 2915428 2605172 1837629 1747942 1272239 1664998 2257959 1311418 1952300 1922006 1757294 1579457 Sphingomyelin (D18:1/14:0- D16:1/16:0) 1559973 1880697 1993214 3350079 1193989 1636330 1335660 1654080 1259969 1536302 1375770 1708056 1367560 1536871 1378328 1913893 Sphingomyelin (D18:1/15:0- D16:1/17:0) 5120679 6930007 6366848 6030237 4721317 5935469 4972506 5314566 4222022 5937025 4933042 4877944 4787596 5509811 4972601 6963215 Sphingomyelin (D18:1/17:0- D17:1/18:0- D19:1/16:0) 7105586 7234554 9546745 7565589 6684917 8883310 6863862 6945373 5092875 7677742 7989802 5635065 6794335 8378642 7541667 7593011 Sphingomyelin (D18:1/18:1- D18:2/18:0) 10079410 7943682 12234954 10017867 8676914 10259296 8826888 10095247 7541999 8758465 9815309 9904595 9823515 10992492 8531156 9198299 Sphingomyelin (D18:1/20:0- D16:1/22:0) 222214928 227409328 227296896 221193616 225103920 276115680 220750208 206123376 174730848 263247104 283169376 203821376 246569840 241431136 238638240 235695168 Sphingomyelin (D18:1/20:1- D18:2/20:0) 60670548 52171072 46411480 57584496 59480288 65717000 55973208 60300520 47068232 63790764 66952660 56104568 69274552 65334672 65523188 54474352 Sphingomyelin (D18:1/21:0- D17:1/22:0- D16:1/23:0) 132178544 107847152 155634000 118802184 130100224 205979872 129123944 118480384 73080616 145904384 165387856 107582832 151022224 174646528 104179832 130523968 Sphingomyelin (D18:1/22:1- D18:2/22:0- D16:1/24:1) 54375904 63231332 42484032 56563544 54156464 67293128 52869620 50878192 41674920 61173992 59528748 47956156 61069748 61474728 58347584 63255776 Sphingomyelin (D18:1/24:1- D18:2/24:0) 111397272 130852456 114247576 120040008 113031000 128372064 110491520 104000632 94292272 114239056 128353120 106490248 115305104 124292984 109068416 140026288 Sphingomyelin (D18:2/16:0- D18:1/16:1) 10762267 17128810 11081706 14740883 9830686 11318083 9592149 10491985 10146510 11544692 11162074 11750039 11051465 11159342 9752444 17324888 Sphingomyelin (D18:2/23:0- D18:1/23:1- D17:1/24:1) 29067932 30247076 33681980 28645402 34836856 39842120 32279994 31732702 21753100 31209456 34373556 29102032 39800844 43819324 26383456 31638444 Sphingomyelin (D18:2/24:1- D18:1/24:2) 31623110 39341872 35369128 36497108 32345232 37135812 29975192 29378620 25911604 33895408 36159840 30486490 33606056 35603540 31704886 41319980 Sphingosine 8308195 9754348 12227536 9122972 9671250 9318180 9260496 9507558 7869071 10597311 10518748 8734805 9292495 9281630 9105544 8627557 Sphingosine 1-Phosphate 173380 1329074 271715 174457 129442 166129 346171 136857 221891 N N 284736 N N 568824 1116748 Stachydrine 23317490 26496920 35824812 27475280 35332124 47929624 23523208 24236414 33308218 31040192 46161680 29812814 37272824 31089044 52567104 48765288 Stearate (18:0) 2132684672 1872177920 5313076224 4716478464 4869925376 1991449728 2528403712 5184550912 2282401024 2090849408 4503444992 2316277504 1868832384 3046195200 2170425088 2182948096 Stearidonate (18:4N3) 3458990 2592799 3219466 8330828 6309168 3155421 4626089 15438246 6069724 5141939 6401234 4264093 2791568 3958391 2555033 2782693 Stearoyl Ethanolamide 2246433 2240440 3837227 2337368 2417288 2552135 2508373 2570481 2084706 2542002 2360588 2426740 2588573 2635812 2078995 2206018 Stearoyl Sphingomyelin (D18:1/18:0) 164840800 135507792 172887584 157989264 115916392 189215664 125152720 126526168 95487224 161747616 180262208 116342536 126114032 144315936 145942384 148638976 Stearoylcarnitine 1807530 3267508 1634992 1548771 1338413 2050867 1726939 1575776 791333 1269847 1497056 1574539 1359659 1642097 1520118 2850699 Succinylcarnitine 296440800 271712832 311036288 272242688 279868064 295877984 350592768 332755168 308817984 314095296 270303104 323775904 292080576 296010336 286018496 286211328 Sulfate 16716970 13404134 17994336 10413112 10245622 13489492 13676328 9274277 8214611 14733024 12005506 11751561 8282372 8284350 22138468 18991424 Sulforaphane-Cysteine-Glycine 385205 496098 661119 600452 492411 512541 240760 N 788081 512750 386292 420486 517915 N N 333136 Tartronate (Hydroxymalonate) 2002317 1676852 1814218 1847152 2050344 1914585 1928360 1805441 1868962 1920862 1989920 1930905 2022870 2220670 2105357 1966327 Taurine 3241902080 3441291264 3332109568 3372906240 3428731136 3474786560 3371099904 3461634048 3214051072 3248602880 3388157696 3268885248 3278580480 3289032192 3412794624 3480100352 Tauro-Beta-Muricholate N 575837 17661644 716275 N 50924 53560 N N N 544689 N N 119927 N N Taurocholate 36220 894577 20120120 1091425 N N 74664 N N 57887 958601 N N 204092 N N Taurocyamine 6057129 5885139 4311307 7276842 6254191 5032714 5889663 6381478 6918592 6846238 5795677 7112906 5256482 4956828 5120304 5187664 Thiamin (Vitamin B1) 160427 160243 194770 202285 196685 157590 130413 145250 182487 184244 156109 140457 160228 170720 145544 146572 Thiamin Diphosphate 696626 747153 527512 626623 694855 783890 816516 627832 695497 775038 726474 620409 808381 635948 898266 848977 Thiamin Monophosphate 79356720 77018936 81726160 86332600 90173472 86383512 78521472 79564784 85365360 86648056 83553880 78579136 79376992 84600648 74867000 78172520 Threonate 142387904 138976544 148308624 134546048 145302160 158356160 165130304 155316096 138315968 145544320 142374848 145136864 141090400 158257216 177526032 178201696 Threonine 501635392 603680256 545820096 562113600 556928640 556469888 557027648 464084768 604766208 578415360 630728576 648937088 613853120 541267072 570132224 560590912 Thymidine 1805580 1943222 2043914 1998739 2221500 1700053 1447787 1607906 1972581 2034338 1625605 1410872 1851378 1662210 1488586 1644973 Thymidine 5^-Monophosphate 393014 382570 344128 264545 242278 351140 316363 323319 400172 365071 222642 360012 292686 330982 333056 362520 Thymine 62555 67520 76421 74054 67318 52720 39557 50378 70604 52643 67404 37511 57478 57385 47638 41540 Tiglylcarnitine 3435536 3821438 5090842 3437121 3868779 4109924 4461715 5322314 3307637 4064371 4816894 3111807 3945520 3771698 3949126 4132841 Trans-4-Hydroxyproline 217762848 293571360 196790784 346861120 260012080 294730784 269270176 265186800 286930560 328171136 258117184 252410976 208853344 235374864 336380736 354846080 Tricarballylate 1992888 1586886 1802752 2092597 1878837 1835856 1540802 1827529 1306662 1573868 1291362 1405845 1291977 1419706 1401404 1490151 Trigonelline (N^-Methylnicotinate) 16181945 16386250 13080635 18166334 17288054 15283852 11937023 12249685 23179448 19541528 18674606 16298811 18531666 16399165 21207606 17322340 Trimethylamine N-Oxide 5092343 4469268 3707054 10595605 10839098 6509843 6200745 7911236 12094630 7442162 7191152 5682976 9508974 5116374 8510661 6317825 Tryptophan 7359414 8326331 9517732 6751824 7622857 7445848 7452010 8022190 6746366 7951686 6799261 6860266 8377616 7294428 7480673 8496678 Tyrosine 892790464 1121776128 1298402432 1112652800 879834880 957858368 697410048 773381504 921931584 975761792 1238166016 789528320 1088274816 780978304 947870016 1031299136 Udp-Galactose 150034 172817 131578 129698 129628 155312 188200 137051 158414 133028 128307 177898 177692 138370 159812 138423 Udp-Glucose 134510 57774 100306 86511 73354 68586 69104 60879 67917 85611 136734 48536 50206 94592 61848 57763 Udp-Glucuronate 134003 143533 210056 199688 211281 192700 160976 208486 192695 160081 119227 197539 179215 177382 176603 181457 Uracil 15825154 18934044 18070068 20418596 20251092 18375640 17251220 18339232 19073852 17770536 17010556 16827660 18396184 21841062 16751412 15898084 Urate 12100426 13330635 8267813 4375660 3295745 7536273 11094101 12333615 6620194 6061626 6926664 7367824 7623982 8570559 17676594 15090353 Urea 81203776 125724576 71360792 110804720 108097664 110030648 91506600 83441776 79609416 90372096 99445096 77685096 101379344 82800176 126434960 131266040 Uridine 30630024 31525418 33142688 35215896 38501664 28048492 31435856 34173280 42713144 36460124 31758772 39596604 39811448 34827672 30270106 32768584 Uridine 5^-Monophosphate (Ump) 13190014 14333428 16584811 11022135 13833850 14404926 15051311 13362791 12151990 12937932 12486948 12413218 10068202 11119618 19072012 20807116 Valine 398833728 487703136 386043680 393652032 359531136 372461792 439437536 408292576 480332032 446934496 427325888 460287648 436924704 431406848 414300416 395130304 Valylglutamine 595692 685264 255707 324061 889849 957992 314883 245287 392633 708304 1143687 463995 699952 552004 1045937 532462 Valylglycine 2974346 3760940 4283963 3793701 4714120 4756452 3140821 3108915 3057558 4056315 5934601 2998337 4414482 3766891 5143387 4403886 Valylleucine 516592 550787 299207 327086 674350 567527 394511 296283 416378 573444 743136 430798 639716 527021 688701 457056 Xanthine 226842672 216305504 232126768 272591456 223461536 218514160 207172000 249378576 250881904 246629488 242117504 221642208 227259120 224429952 187662800 198643312 Xanthosine 842173 751349 461033 1296722 903624 826942 309660 773483 527594 1001852 737532 490380 847426 572580 432026 721047 Xanthosine 5^-Monophosphate (Xmp) 1334833 1561602 1774483 1598757 1564117 1448162 1663891 1485271 2053538 1821777 1586962 1533589 1591656 1333969 1233759 1123656 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name retention index quantified m/z PubChem ID KEGG ID 1-2-Dilinoleoyl-Gpc (18:2/18:2) 2006 5288075 1-2-Dioleoyl-Gpc (18:1/18:1) 2346 10350317 1-2-Dioleoyl-Gpe (18:1/18:1) 2485 9546757 1-2-Dipalmitoyl-Gpc (16:0/16:0) 2365 452110 1-2-Distearoyl-Gpc (18:0/18:0) 3066 94190 1-5-Anhydroglucitol (1-5-Ag) 802 64960 1-(1-Enyl-Oleoyl)-Gpe (P-18:1) 1566 1-(1-Enyl-Palmitoyl)-2-Arachidonoyl-Gpc (P-16:0/20:4) 2154 1-(1-Enyl-Palmitoyl)-2-Arachidonoyl-Gpe (P-16:0/20:4) 2270 1-(1-Enyl-Palmitoyl)-2-Linoleoyl-Gpc (P-16:0/18:2) 2226 1-(1-Enyl-Palmitoyl)-2-Linoleoyl-Gpe (P-16:0/18:2) 2351 1-(1-Enyl-Palmitoyl)-2-Oleoyl-Gpc (P-16:0/18:1) 2443 1-(1-Enyl-Palmitoyl)-2-Oleoyl-Gpe (P-16:0/18:1) 2600 1-(1-Enyl-Palmitoyl)-2-Palmitoyl-Gpc (P-16:0/16:0) 2454 11146967 1-(1-Enyl-Palmitoyl)-Gpc (P-16:0) 1547 10917802 1-(1-Enyl-Palmitoyl)-Gpe (P-16:0) 1558 1-(1-Enyl-Stearoyl)-2-Arachidonoyl-Gpe (P-18:0/20:4) 2511 9547058 1-(1-Enyl-Stearoyl)-2-Linoleoyl-Gpe (P-18:0/18:2) 2633 1-(1-Enyl-Stearoyl)-2-Oleoyl-Gpe (P-18:0/18:1) 2950 1-(1-Enyl-Stearoyl)-Gpe (P-18:0) 6500 1-Arachidonoyl-Gpc (20:4) 1460 1-Arachidonoyl-Gpe (20:4) 1450 42607465 1-Arachidonoyl-Gpi (20:4) 5482 1-Arachidonylglycerol (20:4) 6450 5282281 1-Dihomo-Linolenylglycerol (20:3) 6220 1-Dihomo-Linoleoylglycerol (20:2) 6800 1-Docosahexaenoylglycerol (22:6) 6150 1-Lignoceroyl-Gpc (24:0) 1907 1-Linolenoyl-Gpc (18:3) 1422 1-Linoleoyl-2-Arachidonoyl-Gpc (18:2/20:4) 1969 1-Linoleoyl-Gpc (18:2) 1465 11988421 1-Linoleoyl-Gpe (18:2) 1482 52925130 1-Linoleoyl-Gpi (18:2) 5494 1-Linoleoylglycerol (18:2) 6477 5283469 1-Methylguanidine 2149 10111 1-Methylhistidine 2755 92105 1-Methylimidazoleacetate 2064 75810 1-Methylnicotinamide 1940 10129985 1-Myristoylglycerol (14:0) 6353.3 79050 1-Oleoyl-2-Linoleoyl-Glycerol (18:1/18:2) 3115 1-Oleoyl-2-Linoleoyl-Gpc (18:1/18:2) 2165 1-Oleoyl-2-Linoleoyl-Gpe (18:1/18:2) 2270 9546753 1-Oleoyl-3-Linoleoyl-Glycerol (18:1/18:2) 3223 1-Oleoyl-Gpc (18:1) 1540 16081932 1-Oleoyl-Gpe (18:1) 1554 9547071 1-Oleoyl-Gpg (18:1) 5610 1-Oleoyl-Gpi (18:1) 5599 1-Oleoylglycerol (18:1) 6300 5283468 1-Palmitoleoyl-2-Linoleoyl-Gpc (16:1/18:2) 2003 1-Palmitoleoyl-Gpc (16:1) 1450 24779461 1-Palmitoleoylglycerol (16:1) 6094 1-Palmitoyl-2-Arachidonoyl-Gpc (16:0/20:4) 2091 10747814 1-Palmitoyl-2-Arachidonoyl-Gpe (16:0/20:4) 2198 9546800 1-Palmitoyl-2-Linolenoyl-Gpg (16:0/18:3) 728 1-Palmitoyl-2-Linoleoyl-Glycerol (16:0/18:2) 3080 9543695 1-Palmitoyl-2-Linoleoyl-Gpc (16:0/18:2) 2160 5287971 1-Palmitoyl-2-Linoleoyl-Gpe (16:0/18:2) 2275 9546747 1-Palmitoyl-2-Linoleoyl-Gpg (16:0/18:2) 717 1-Palmitoyl-2-Oleoyl-Gpc (16:0/18:1) 2358 6436017 1-Palmitoyl-2-Oleoyl-Gpe (16:0/18:1) 2509 5283496 1-Palmitoyl-2-Oleoyl-Gpg (16:0/18:1) 745 5283509 1-Palmitoyl-2-Palmitoleoyl-Gpc (16:0/16:1) 2160 1-Palmitoyl-2-Stearoyl-Gpc (16:0/18:0) 2653 1-Palmitoyl-Gpc (16:0) 1525 86554 1-Palmitoyl-Gpe (16:0) 1544 9547069 1-Palmitoyl-Gpg (16:0) 5570 3300276 1-Palmitoyl-Gpi (16:0) 5564 1-Palmitoylglycerol (16:0) 6400 14900 1-Stearoyl-2-Arachidonoyl-Gpc (18:0/20:4) 2300 16219824 1-Stearoyl-2-Arachidonoyl-Gpe (18:0/20:4) 2424 5289133 1-Stearoyl-2-Arachidonoyl-Gpi (18:0/20:4) 870 1-Stearoyl-2-Arachidonoyl-Gps (18:0/20:4) 2565 1-Stearoyl-2-Linoleoyl-Gpc (18:0/18:2) 2380 1-Stearoyl-2-Linoleoyl-Gpe (18:0/18:2) 2522 9546749 1-Stearoyl-2-Oleoyl-Gpc (18:0/18:1) 2644 1-Stearoyl-2-Oleoyl-Gpe (18:0/18:1) 2858 1-Stearoyl-Gpc (18:0) 1606 497299 1-Stearoyl-Gpe (18:0) 1626 9547068 1-Stearoyl-Gpg (18:0) 5816 1-Stearoyl-Gpi (18:0) 5794.3 1-Stearoyl-Gps (18:0) 5800 9547101 10-Heptadecenoate (17:1N7) 5555 5312435 10-Nonadecenoate (19:1N9) 5780 5312513 12-13-Dihome 5137 10236635 12-Hete 5326 5312983 13-Hode + 9-Hode 5275 43013 14-Hdohe/17-Hdohe 5296 15-Methylpalmitate 5695 17903417 17-Methylstearate 5993 3083779 2^-Deoxyadenosine 5^-Monophosphate 1315 12599 2^-Deoxycytidine 2193 13711 2^-Deoxyguanosine 1751 187790 2^-Deoxyinosine 1688 65058 2^-Deoxyuridine 1586 13712 2-Aminoadipate 1912 469 2-Aminoheptanoate 3160 227939 2-Aminooctanoate 750 69522 2-Aminophenol Sulfate 1677 181670 2-Arachidonoylglycerol (20:4) 6170 5282280 2-Docosahexaenoylglycerol (22:6) 6000 2-Hydroxy-3-Methylvalerate 1800 164623 2-Hydroxyadipate 3000 193530 2-Hydroxybutyrate/2-Hydroxyisobutyrate 1258 2-Hydroxydecanoate 4840 21488 2-Hydroxyglutarate 3352.8 43 2-Hydroxyoctanoate 3736.8 94180 2-Hydroxystearate 5695 69417 2-Linoleoylglycerol (18:2) 6250 5365676 2-Methylcitrate/Homocitrate 575 2-Methylmalonyl Carnitine 2440 53481628 2-Oleoylglycerol (18:1) 6200 5319879 2-Palmitoleoyl-Gpc (16:1) 1425 2-Palmitoleoylglycerol (16:1) 6016 2-Palmitoyl-Gpc (16:0) 1505 15061532 2-Palmitoylglycerol (16:0) 6200 123409 2-Phosphoglycerate 4346 59 2-Piperidinone 1675 12665 3^-Dephosphocoenzyme A 2013 444485 3-(3-Hydroxyphenyl)Propionate Sulfate 1294 187488 3-(4-Hydroxyphenyl)Lactate 1379 9378 3-(4-Hydroxyphenyl)Propionate 1670 10394 3-Aminoisobutyrate 2215 64956 3-Hydroxy-3-Methylglutarate 2700 1662 3-Hydroxybutyrate (Bhba) 1443.3 441 3-Hydroxybutyryl Coa 1715 521 3-Hydroxybutyrylcarnitine (1) 2400 53481617 3-Hydroxybutyrylcarnitine (2) 2340 3-Hydroxydecanoate 4634.7 26612 3-Hydroxyisobutyrate 1619.1 87 3-Hydroxylaurate 5175 94216 3-Hydroxymyristate 5335 16064 3-Hydroxyoctanoate 3446 26613 3-Hydroxypalmitate 5476 301590 3-Hydroxystearate 5674 5282907 3-Indoxyl Sulfate 2222.2 10258 3-Methylhistidine 2670 64969 3-Phosphoglycerate 4410 724 3-Ureidopropionate 875 111 4-Cholesten-3-One 2520 91477 4-Guanidinobutanoate 2320 500 4-Hydroxy-2-Nonenal 4745 1693 4-Hydroxy-Nonenal-Glutathione 3319.2 4-Hydroxybutyrate (Ghb) 1765 10413 4-Hydroxyglutamate 1141 439902 4-Hydroxyphenylpyruvate 1690.1 979 4-Imidazoleacetate 2055 96215 4-Vinylphenol Sulfate 3320 6426766 5-(2-Hydroxyethyl)-4-Methylthiazole 2310 1136 5-Aminovalerate 2220 138 5-Dodecenoate (12:1N7) 5224 5312378 5-Hydroxylysine 2790 1029 5-Methyl-2^-Deoxycytidine 2303 440055 5-Methylcytidine 2227 92918 5-Methylthioadenosine (Mta) 2752 439176 5-Oxoproline 738.5 7405 6-Phosphogluconate 583.9 91493 7-Hydroxycholesterol (Alpha Or Beta) 1930 7-Methylguanine 2175 11361 8-Hydroxyoctanoate 2300.4 69820 9-10-Dihome 5180 9966640 Acetyl Coa 1691 444493 Acetylcarnitine 2282 1 Acetylcholine 2220 Acetylphosphate 4013.9 186 Adenine 2221 190 Adenosine 2169 60961 Adenosine 2^-Monophosphate (2^-Amp) 1497.7 94136 Adenosine 3^-5^-Cyclic Monophosphate (Camp) 1952.2 6076 Adenosine 3^-5^-Diphosphate 575 159296 Adenosine 3^-Monophosphate (3^-Amp) 1245 41211 Adenosine 5^-Diphosphate (Adp) 680 6022 Adenosine 5^-Diphosphoribose (Adp-Ribose) 553 192 Adenosine 5^-Monophosphate (Amp) 1013 6083 Adenosine 5^-Triphosphate (Atp) . Adenylosuccinate 560 195 Adrenate (22:4N6) 5678 5497181 Aica Ribonucleotide 797 65110 Alanine 1700 5950 Alanylleucine 3055 259583 Allantoin 1672 204 Alpha-Hydroxyisocaproate 1840 83697 Alpha-Hydroxyisovalerate 1126 99823 Alpha-Ketoglutarate 2700 51 Alpha-Tocopherol 2522 14985 Anserine 2924 112072 Arabitol/Xylitol 1932.4 Arabonate/Xylonate 2664.6 Arachidate (20:0) 6295 10467 Arachidonate (20:4N6) 5535 444899 Arachidonoyl Ethanolamide 1535 5281969 Arginine 2825 232 Argininosuccinate 2745 16950;828 Asparagine 1225 6267 Aspartate 1165 5960 Azelate (Nonanedioate) 1276 2266 Behenoyl Sphingomyelin (D18:1/22:0) 3083 Beta-Alanine 1939 239 Beta-Hydroxyisovalerate 1149.8 69362 Beta-Hydroxyisovaleroylcarnitine 2584 Beta-Muricholate 4794 5283853 Beta-Sitosterol 3054 222284 Betaine 1064 247 Betaine Aldehyde 1915 249 C-Glycosyltryptophan 2685 10981970 Campesterol 2873 173183 Caproate (6:0) 2713.7 8892 Caprylate (8:0) 4362 379 Carnitine 1978 10917 Carnosine 804 439224 Catechol Sulfate 1906 3083879 Cholate 5165 221493 Cholesterol 2707 11025495 Choline 1961 305 Choline Phosphate 700 1014 Citrate 582 311 Citrulline 1520 9750 Coenzyme A 1448 317 Corticosterone 5040 5753 Creatine 1947 586 Creatinine 2055 588 Cystathionine 2270 439258 Cysteine-Glutathione Disulfide 2465 4247235 Cytidine 2124 6175 Cytidine 5^-Diphosphocholine 4200 13804 Cytidine 5^-Monophosphate (5^-Cmp) 835 6131 Cytidine 5^-Monophospho-N-Acetylneuraminic Acid 3900 448209 Cytidine-5^-Diphosphoethanolamine 4210 123727 Cytosine 2060 597 Decanoylcarnitine 1130 10245190 Dehydroascorbate 739.6 835 Deoxycarnitine 2052 134 Dihomo-Linoleate (20:2N6) 5730 6439848 Dihomo-Linolenate (20:3N3 Or N6) 5596 5280581 Dihydroxyacetone Phosphate (Dhap) 603 668 Dimethylarginine (Sdma + Adma) 2850 123831 Dimethylglycine 1104 673 Docosadienoate (22:2N6) 6034 5282807 Docosahexaenoate (Dha; 22:6N3) 5525 445580 Docosapentaenoate (N3 Dpa; 22:5N3) 5571 6441454 Docosapentaenoate (N6 Dpa; 22:5N6) 5624.5 6441454 Docosatrienoate (22:3N3) 5823 5312556 Dopamine Sulfate (2) 1556.2 Eicosapentaenoate (Epa; 20:5N3) 5450 446284 Eicosenoate (20:1) 5950 5282768 Ergothioneine 850 3032311 Erucate (22:1N9) 6355.6 5281116 Erythronate 2186 2781043 Ethylmalonate 2785 11756 Flavin Adenine Dinucleotide (Fad) 2425 643975 Flavin Mononucleotide (Fmn) 2390 710 Fructose 2022.2 5984 Fructose-6-Phosphate 4261.4 69507 Fumarate 3084 444972 Galactitol (Dulcitol) 2309.7 11850 Galactonate 3085 128869 Gamma-Aminobutyrate (Gaba) 2048 119 Gamma-Glutamyl-Epsilon-Lysine 2717 65254;14284565 Gamma-Glutamylglutamine 1430 150914 Gamma-Glutamylhistidine 2740 7017195 Gamma-Glutamylisoleucine 2940 14253342 Gamma-Glutamylleucine 2991 151023 Gamma-Glutamylphenylalanine 2992 111299 Gamma-Glutamylthreonine 1750 Gamma-Glutamylvaline 2700 7015683 Gluconate 2922 10690 Glucosamine-6-Phosphate 4521.5 439217 Glucose 2342 79025 Glucose 6-Phosphate 4537 5958 Glucuronate 3233.3 444791 Glutamate 1500 611 Glutamate- Gamma-Methyl Ester 2170 68662 Glutamine 1291 5961 Glutarate (Pentanedioate) 2900 743 Glutarylcarnitine (C5) 2393 71464488 Glutathione- Oxidized (Gssg) 2667 65359 Glutathione- Reduced (Gsh) 790 124886 Glycerate 2070.4 752 Glycerol 758 753 Glycerol 3-Phosphate 3938.7 754 Glycerophosphoethanolamine 3075 123874 Glycerophosphoglycerol 2430 439964 Glycerophosphoinositol 3850 Glycerophosphorylcholine (Gpc) 672 71920 Glycine 1375 750 Glycosyl-N-Palmitoyl-Sphingosine 2623 Glycosyl-N-Stearoyl-Sphingosine 3053 Glycylisoleucine 3002 88079 Glycylleucine 3059 92843 Glycylvaline 2734 97417 Guanidinoacetate 2884 763 Guanidinosuccinate 1892 97856 Guanine 2032 764 Guanosine 1728 6802 Guanosine 5^- Monophosphate (5^-Gmp) 800 6804 Gulonic Acid 2750 9794176 Hexanoylglycine 2900 99463 Hippurate 2106.9 464 Histamine 3035 774 Histidine 755.9 6274 Homoarginine 2882 9085 Homoserine 2875.8 12647 Homostachydrine 1750 441447 Hypotaurine 2763.4 107812 Hypoxanthine 1291.2 790 Imidazole Lactate 2040 440129 Imidazole Propionate 2263 70630 Indolelactate 2600 92904 Indolepropionate 2795 3744 Inosine 1602.1 6021 Inosine 5^-Monophosphate (Imp) 650 8582 Inositol 1-Phosphate (I1P) 4785 440194 Isobar: Fructose 1-6-Diphosphate- Glucose 1-6-Diphosphate- Myo-Inositol 1-4 Or 1-3-Diphosphate 551 Isobutyrylcarnitine 2810 168379 Isocitrate 773 1198 Isoleucine 2800 6306 Isoleucylglycine 2719 342532 Isovalerylglycine 1950 546304 Kynurenine 2739 161166 Lactate 681.6 612 Laurylcarnitine 1235 10427569 Leucine 2864 6106 Leucylalanine 2801 259321 Leucylglutamine 2620 4305457 Leucylglycine 2778 79070 Linoleamide (18:2N6) 6205 6435901 Linoleate (18:2N6) 5535 5280450 Linolenate [Alpha Or Gamma; (18:3N3 Or 6)] 5450 5280934 Linoleoylcarnitine 1430 6450015 Lysine 2850 5962 Malate 615.6 525 Maleate 2510 444266 Malonyl Coa 1325 10663 Malonylcarnitine 2086 22833583 Maltose 3329.4 10991489 Maltotetraose 910 446495 Maltotriose 812 439586 Mannitol/Sorbitol 2260 5780 Mannose 2200 18950 Mannose-6-Phosphate 4510 439198 Margarate (17:0) 5731 10465 Mead Acid (20:3N9) 5650 5312531 Methionine 2526 6137 Methionine Sulfone 740.8 69961 Methionine Sulfoxide 1272 158980 Methyl Glucopyranoside (Alpha + Beta) 1070 Methylmalonate (Mma) 3078.4 487 Methylphosphate 3760.1 13130 Methylsuccinate 2800 10349 Myo-Inositol 3506.3 892 Myristate (14:0) 5440 11005 Myristoleate (14:1N5) 5346.9 5281119 Myristoylcarnitine 1350 53477791 N-Acetyl-Aspartyl-Glutamate (Naag) 575.3 5255 N-Acetylalanine 861.2 88064 N-Acetylarginine 2245 67427 N-Acetylasparagine 785 99715 N-Acetylaspartate (Naa) 3143 65065 N-Acetylglucosamine 6-Phosphate 4114 439219 N-Acetylglucosaminylasparagine 1212 123826 N-Acetylglutamate 1050 70914 N-Acetylglutamine 845 182230 N-Acetylglycine 731 10972 N-Acetylhistamine 2287 69602 N-Acetylhistidine 2065 75619 N-Acetylleucine 2400 70912 N-Acetylmethionine 1980 448580 N-Acetylmethionine Sulfoxide 942 193368 N-Acetylneuraminate 3072.6 439197 N-Acetylphenylalanine 2597 74839 N-Acetylserine 811 65249 N-Acetyltaurine 1249 159864 N-Acetylthreonine 821.6 152204 N-Alpha-Acetylornithine 2000 439232 N-Delta-Acetylornithine 1877 9920500 N-Formylmethionine 1543.8 439750 N-Formylphenylalanine 2336 759256 N-Glycolylneuraminate 636 123802 N-Methylproline 1335 557 N-Monomethylarginine 2845 132862 N-Oleoyltaurine 5610 6437033 N-Palmitoyl-Sphinganine (D18:0/16:0) 3090 5283572 N-Palmitoyl-Sphingosine (D18:1/16:0) 2893 5283564 N-Palmitoyltaurine 5560 N-Stearoyltaurine 5782 168274 N1-Methyl-2-Pyridone-5-Carboxamide 1250 69698 N1-Methyladenosine 2120 27476 N2-N2-Dimethylguanosine 2210 92919 N4-Acetylcytidine 1580 107461 N6-N6-N6-Trimethyllysine 2825 440120 N6-Acetyllysine 1059 92832 N6-Carboxyethyllysine 2695 N6-Carboxymethyllysine 2592 N6-Succinyladenosine 1930 Nicotinamide 1942 936 Nicotinamide Adenine Dinucleotide (Nad+) 1434 5893 Nicotinamide Ribonucleotide (Nmn) 766 14180 Nicotinamide Riboside 2040 439924 Nonadecanoate (19:0) 6068 12591 Oleamide 6581.5 5283387 Oleate/Vaccenate (18:1) 5655 Oleoyl Ethanolamide 6200 5283454 Oleoylcarnitine 1423 6441392;53477789 Ophthalmate 2085 7018721 Ornithine 2800 6262 Orotate 1638.1 967 Orotidine 2250 92751 P-Cresol Sulfate 2890 4615423 Palmitate (16:0) 5618 985 Palmitoleate (16:1N7) 5475 445638 Palmitoyl Dihydrosphingomyelin (D18:0/16:0) 2290 9939965 Palmitoyl Ethanolamide 6100 4671 Palmitoyl Sphingomyelin (D18:1/16:0) 870 9939941 Palmitoylcarnitine 1425 461 Palmitoylcholine 1482 151731 Pantothenate 1498.7 6613 Pentadecanoate (15:0) 5521 13849 Phenol Sulfate 2156 74426 Phenylacetylglycine 2317 68144 Phenylalanine 2878 6140 Phenylalanylalanine 2909 6993123;5488196 Phenylalanylglycine 2898 98207 Phenyllactate (Pla) 2208 3848 Phosphate 608 1061 Phosphoenolpyruvate (Pep) 587.3 1005 Phosphoethanolamine 638 1015 Phosphopantetheine 1596.9 987 Phytosphingosine 1367 122121 Pipecolate 2200 849 Pro-Hydroxy-Pro 2128 11673055 Proline 1603 145742 Prolylglutamine 2056 Prolylglycine 2136 7408076;6426709 Propionylcarnitine 2590 107738 Pseudouridine 800 15047 Pterin 1370 73000 Putrescine 3027 1045 Pyridoxal 2343 1050 Pyridoxal Phosphate 943 1051 Pyridoxamine Phosphate 1932 1053 Pyridoxate 2185 6723 Pyroglutamine 1900 134508 Pyrraline 2750 Pyruvate 2650 1060 Retinol (Vitamin A) 1636 445354 Ribitol 1789.6 6912 Riboflavin (Vitamin B2) 2292 493570 Ribonate 2425 5460677 Ribose 1508.2 5779 Ribose 1-Phosphate 4025 439236 Ribulose/Xylulose 1400 S-Adenosylhomocysteine (Sah) 1832.4 439155 S-Adenosylmethionine (Sam) 3002 34755 S-Lactoylglutathione 2124 440018 S-Methylcysteine 1955 24417 S-Methylglutathione 2200 3605667 Sarcosine (N-Methylglycine) 1280 1088 Sedoheptulose-7-Phosphate 599.6 616 Serine 1239 5951 Spermidine 700 1102 Sphinganine 1413 3126 Sphingomyelin (D18:1/14:0- D16:1/16:0) 1998 11433862 Sphingomyelin (D18:1/15:0- D16:1/17:0) 2082 Sphingomyelin (D18:1/17:0- D17:1/18:0- D19:1/16:0) 2312 Sphingomyelin (D18:1/18:1- D18:2/18:0) 2167 6443882 Sphingomyelin (D18:1/20:0- D16:1/22:0) 2685 Sphingomyelin (D18:1/20:1- D18:2/20:0) 2383 Sphingomyelin (D18:1/21:0- D17:1/22:0- D16:1/23:0) 2793 Sphingomyelin (D18:1/22:1- D18:2/22:0- D16:1/24:1) 2666 Sphingomyelin (D18:1/24:1- D18:2/24:0) 3033 Sphingomyelin (D18:2/16:0- D18:1/16:1) 2002 Sphingomyelin (D18:2/23:0- D18:1/23:1- D17:1/24:1) 2845 Sphingomyelin (D18:2/24:1- D18:1/24:2) 2635 Sphingosine 1393 5353955 Sphingosine 1-Phosphate 1375 5283560 Stachydrine 1440 115244 Stearate (18:0) 5872 5281 Stearidonate (18:4N3) 5395 5312508 Stearoyl Ethanolamide 1787 27902 Stearoyl Sphingomyelin (D18:1/18:0) 2400 6453725 Stearoylcarnitine 1485 6426855 Succinylcarnitine 2291 Sulfate 3728 1118 Sulforaphane-Cysteine-Glycine 2610 Tartronate (Hydroxymalonate) 610 45 Taurine 660 1123 Tauro-Beta-Muricholate 4774 168408 Taurocholate 5150 6675 Taurocyamine 710 68340 Thiamin (Vitamin B1) 1726 1130 Thiamin Diphosphate 1195.1 1132 Thiamin Monophosphate 2378 3382778 Threonate 2384 151152 Threonine 1514 6288 Thymidine 1963.7 5789 Thymidine 5^-Monophosphate 883 9700 Thymine 1654 1135 Tiglylcarnitine 2962 22833596 Trans-4-Hydroxyproline 1064 5810 Tricarballylate 578 14925 Trigonelline (N^-Methylnicotinate) 1388 5570 Trimethylamine N-Oxide 2100 1145 Tryptophan 2291 6305 Tyrosine 2430 6057 Udp-Galactose 4000 18068 Udp-Glucose 3950 8629 Udp-Glucuronate 4355 17473 Uracil 1089.7 1174 Urate 776 1175 Urea 700 1176 Uridine 1457.6 6029 Uridine 5^-Monophosphate (Ump) 590 6030 Valine 2479 6287 Valylglutamine 2295 5253209 Valylglycine 2444 136487 Valylleucine 3138 352039 Xanthine 1032 1188 Xanthosine 1275 64959 Xanthosine 5^-Monophosphate (Xmp) 580 73323 METABOLITES_END #END