#METABOLOMICS WORKBENCH hormel101_20180710_090204_mwtab.txt DATATRACK_ID:1439 STUDY_ID:ST001002 ANALYSIS_ID:AN001637 PROJECT_ID:PR000678 VERSION 1 CREATED_ON July 11, 2018, 4:04 pm #PROJECT PR:PROJECT_TITLE Mayo Pilot and Feasibility: A pilot study of urine metabolomics towards an PR:PROJECT_TITLE outpatient estimate of circadian phase PR:PROJECT_SUMMARY "Although the effectiveness of several therapeutic interventions depend PR:PROJECT_SUMMARY critically on their timing with respect to circadian phase, including the timing PR:PROJECT_SUMMARY of light therapy for circadian rhythm sleep disorders, medications for high PR:PROJECT_SUMMARY blood pressure, and chemotherapy treatments for cancer, no clinical test is PR:PROJECT_SUMMARY available to reliably measure circadian phase rapidly, inexpensively, and PR:PROJECT_SUMMARY non-invasively. This project will therefore provide the essential first steps PR:PROJECT_SUMMARY toward the development and validation of a clinical test to estimate circadian PR:PROJECT_SUMMARY phase from a single urine void via the identification of multiple rhythmic PR:PROJECT_SUMMARY metabolites in urine using untargeted metabolomic profiling methods. Current PR:PROJECT_SUMMARY methods to assess circadian phase in urine require serial measurement of a PR:PROJECT_SUMMARY single compound (e.g., 6-sulphatoxymelatonin, the urinary metabolite of PR:PROJECT_SUMMARY melatonin) over a 24- to 48-hour sampling window. Our approach proposes to PR:PROJECT_SUMMARY assess many compounds in one sample to estimate circadian phase, based on the PR:PROJECT_SUMMARY phase relationships across multiple parameters, an approach that is supported by PR:PROJECT_SUMMARY our theoretical modeling framework. Using the untargeted metabolomics profiling PR:PROJECT_SUMMARY services offered by the Mayo Clinic Metabolomics Resource Core, we will examine PR:PROJECT_SUMMARY the 48-hour profiles of ~300 metabolites identified from urine samples collected PR:PROJECT_SUMMARY in a randomly selected pilot sample of 12 healthy young volunteers (from >200 PR:PROJECT_SUMMARY subjects) studied on an inpatient laboratory protocol that included both an PR:PROJECT_SUMMARY ambulatory condition (i.e., habitual sleep-wake times under ordinary room light) PR:PROJECT_SUMMARY and a constant routine procedure, the gold standard method for assessing PR:PROJECT_SUMMARY circadian rhythms (i.e., 50-hour period during which subjects remain awake in a PR:PROJECT_SUMMARY semi-recumbent posture in bed under dim light with equicaloric snacks served PR:PROJECT_SUMMARY hourly). Cosinor analysis will be employed to determine which identified PR:PROJECT_SUMMARY metabolites exhibit circadian rhythmicity, and comparisons between ambulatory PR:PROJECT_SUMMARY and constantroutine conditions will further identify which metabolites are PR:PROJECT_SUMMARY influenced by external factors such as sleep, meal timing, light, and posture. PR:PROJECT_SUMMARY Finally, we will employ our theoretical modeling framework to estimate circadian PR:PROJECT_SUMMARY phase from a single urine void using the concentration ratios of multiple PR:PROJECT_SUMMARY metabolites that exhibit reliable and robust circadian rhythmicity. The accuracy PR:PROJECT_SUMMARY of estimated circadian phase will be determined by comparison to actual PR:PROJECT_SUMMARY circadian phase as defined by the peak of the 6-sulphatoxymelatonin rhythm. Once PR:PROJECT_SUMMARY this approach has been established in a pilot set of subjects, future studies PR:PROJECT_SUMMARY will focus on validation and testing of this approach in other data from our PR:PROJECT_SUMMARY repository, including healthy young volunteers who have undergone rapid phase PR:PROJECT_SUMMARY shift due to changes in sleep-wake schedule (i.e., simulated shift work) or in PR:PROJECT_SUMMARY response to bright light exposure; patients with insomnia, who exhibit an 8-hour PR:PROJECT_SUMMARY range in circadian phase; and blind participants without light perception, who PR:PROJECT_SUMMARY exhibit non-entrained rhythms. Future studies will also test the efficacy of PR:PROJECT_SUMMARY this method to a priori estimate circadian phase in patient populations that may PR:PROJECT_SUMMARY benefit from improvements in circadian timing of treatment. The current proposal PR:PROJECT_SUMMARY therefore represents the first essential step in developing a tool that can PR:PROJECT_SUMMARY revolutionize medicine by adding an accurate measure of internal time – PR:PROJECT_SUMMARY circadian medicine – into standard clinical practice. PR:INSTITUTE Mayo Clinic PR:LAST_NAME Hilaire PR:FIRST_NAME Melissa PR:ADDRESS 221 Longwood Avenue, Suite BL438 Boston, Massachusetts 02115 PR:EMAIL msthilaire@rics.bwh.harvard.edu PR:PHONE 617-732-4013 #STUDY ST:STUDY_TITLE A pilot study of urine metabolomics in two female and one male subject towards ST:STUDY_TITLE an outpatient estimate of circadian phase using urine storage as a factor (part ST:STUDY_TITLE II) ST:STUDY_SUMMARY Serial urine samples were collected at each void (approximately every 3 hours) ST:STUDY_SUMMARY from subjects during a 6-day inpatient protocol. The total volume of each sample ST:STUDY_SUMMARY was measured, and then 5 mL was aliquoted into a 7 mL tube and elivered on ice ST:STUDY_SUMMARY to the processing lab, where the samples were then stored at either -20 degrees ST:STUDY_SUMMARY or -80 degrees (see details below). At the end of the study, samples were ST:STUDY_SUMMARY transported (~2 blocks) from the processing lab to our -20 or -80 freezer for ST:STUDY_SUMMARY storage. The samples being sent represent samples from two female subjects ST:STUDY_SUMMARY (3634A and 3635A) and one male subject (3624A). These subjects all spent 6 days ST:STUDY_SUMMARY in the lab: 3 baseline days where the subjects slept for 8 hours at night (at ST:STUDY_SUMMARY habitual times as determined during the screening period) and 16 hours of ST:STUDY_SUMMARY ambulatory wake in ambient light, followed by 50 hours of continuous wakefulness ST:STUDY_SUMMARY in which the subject was kept in a semi-recumbent position in bed under dim ST:STUDY_SUMMARY light and fed hourly isocaloric snacks (called a "constant routine"). We are ST:STUDY_SUMMARY requesting untargeted profiling of samples from these subjects (plus ST:STUDY_SUMMARY 6-sulphatoxymelatonin profile) to determine how the concentrations of different ST:STUDY_SUMMARY metabolites vary across the 24-hour period, and specifically to compare this ST:STUDY_SUMMARY circadian variation in each metabolite during a 48-hour ambulatory period versus ST:STUDY_SUMMARY a 48-hour constant routine period. ST:INSTITUTE Mayo Clinic ST:LAST_NAME Hilaire ST:FIRST_NAME Melissa ST:ADDRESS 221 Longwood Avenue, Suite BL438 Boston, Massachusetts 02115 ST:EMAIL msthilaire@rics.bwh.harvard.edu ST:PHONE 617-732-4013 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-084 hour:5 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-084 hour:5 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-084 hour:5 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-084 hour:5 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-085 hour:7 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-085 hour:7 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-085 hour:7 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-085 hour:7 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-086 hour:9 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-086 hour:9 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-086 hour:9 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-086 hour:9 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-087 hour:10 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-087 hour:10 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-087 hour:10 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-087 hour:10 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-088 hour:11 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-088 hour:11 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-088 hour:11 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-088 hour:11 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-089 hour:13 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-089 hour:13 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-089 hour:13 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-089 hour:13 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-090 hour:14 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-090 hour:14 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-090 hour:14 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-090 hour:14 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-091 hour:17 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-091 hour:17 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-091 hour:17 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-091 hour:17 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-092 hour:18 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-092 hour:18 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-092 hour:18 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-092 hour:18 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-093 hour:20 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-093 hour:20 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-093 hour:20 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-093 hour:20 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-094 hour:4 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-094 hour:4 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-094 hour:4 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-094 hour:4 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-095 hour:7 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-095 hour:7 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-095 hour:7 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-095 hour:7 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-096 hour:9 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-096 hour:9 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-096 hour:9 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-096 hour:9 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-097 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-097 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-097 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-097 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-098 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-098 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-098 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-098 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-099 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-099 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-099 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-099 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-100 hour:16 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-100 hour:16 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-100 hour:16 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-100 hour:16 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-101 hour:17 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-101 hour:17 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-101 hour:17 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-101 hour:17 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-102 hour:20 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-102 hour:20 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-102 hour:20 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-102 hour:20 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-103 hour:- | day:day3 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-103 hour:- | day:day3 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-103 hour:- | day:day3 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-103 hour:- | day:day3 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-17aug17-104 hour:5 | day:day3 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-12aug17-104 hour:5 | day:day3 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-16aug17-104 hour:5 | day:day3 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-11aug17-104 hour:5 | day:day3 | Group:Baseline -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-105 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-105 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-105 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-105 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-106 hour:9 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-106 hour:9 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-106 hour:9 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-106 hour:9 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-107 hour:11 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-107 hour:11 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-107 hour:11 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-107 hour:11 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-108 hour:14 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-108 hour:14 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-108 hour:14 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-108 hour:14 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-109 hour:17 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-109 hour:17 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-109 hour:17 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-109 hour:17 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-110 hour:19 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-110 hour:19 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-110 hour:19 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-110 hour:19 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-111 hour:20 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-111 hour:20 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-111 hour:20 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-111 hour:20 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-112 hour:23 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-112 hour:23 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-112 hour:23 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-112 hour:23 | day:day3 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-113 hour:2 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-113 hour:2 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-113 hour:2 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-113 hour:2 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-114 hour:4 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-114 hour:4 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-114 hour:4 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-114 hour:4 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-115 hour:5 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-115 hour:5 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-115 hour:5 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-115 hour:5 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-116 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-116 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-116 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-116 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-117 hour:7 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-117 hour:7 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-117 hour:7 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-117 hour:7 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-118 hour:8 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-118 hour:8 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-118 hour:8 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-118 hour:8 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-119 hour:10 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-119 hour:10 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-119 hour:10 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-119 hour:10 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-120 hour:11 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-120 hour:11 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-120 hour:11 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-120 hour:11 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-121 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-121 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-121 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-121 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-122 hour:16 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-122 hour:16 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-122 hour:16 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-122 hour:16 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-123 hour:17 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-123 hour:17 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-123 hour:17 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-123 hour:17 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-124 hour:20 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-124 hour:20 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-124 hour:20 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-124 hour:20 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-125 hour:23 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-125 hour:23 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-125 hour:23 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-125 hour:23 | day:day4 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-126 hour:2 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-126 hour:2 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-126 hour:2 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-126 hour:2 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-127 hour:4 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-127 hour:4 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-127 hour:4 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-127 hour:4 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-128 hour:5 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-128 hour:5 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-128 hour:5 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-128 hour:5 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3624A nC18-19aug17-129 hour:7 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3624A nhilic-15aug17-129 hour:7 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3624A pC18-18aug17-129 hour:7 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3624A philic-14aug17-129 hour:7 | day:day5 | Group:CR -20 storage Type=Urine; sex=M; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-026 hour:6 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-055 hour:6 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-026 hour:6 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-055 hour:6 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-026 hour:6 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-055 hour:6 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-026 hour:6 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-055 hour:6 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-027 hour:12 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-056 hour:12 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-027 hour:12 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-056 hour:12 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-027 hour:12 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-056 hour:12 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-027 hour:12 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-056 hour:12 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-028 hour:14 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-057 hour:14 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-028 hour:14 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-057 hour:14 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-028 hour:14 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-057 hour:14 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-028 hour:14 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-057 hour:14 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-029 hour:16 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-058 hour:16 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-029 hour:16 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-058 hour:16 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-029 hour:16 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-058 hour:16 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-029 hour:16 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-058 hour:16 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-030 hour:20 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-059 hour:20 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-030 hour:20 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-059 hour:20 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-030 hour:20 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-059 hour:20 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-030 hour:20 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-059 hour:20 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-031 hour:22 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-060 hour:22 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-031 hour:22 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-060 hour:22 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-031 hour:22 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-060 hour:22 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-031 hour:22 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-060 hour:22 | day:day1 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-032 hour:6 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-061 hour:6 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-032 hour:6 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-061 hour:6 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-032 hour:6 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-061 hour:6 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-032 hour:6 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-061 hour:6 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-033 hour:9 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-062 hour:9 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-033 hour:9 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-062 hour:9 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-033 hour:9 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-062 hour:9 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-033 hour:9 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-062 hour:9 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-034 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-063 hour:11 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-034 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-063 hour:11 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-034 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-063 hour:11 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-034 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-063 hour:11 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-035 hour:12 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-064 hour:12 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-035 hour:12 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-064 hour:12 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-035 hour:12 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-064 hour:12 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-035 hour:12 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-064 hour:12 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-036 hour:13 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-065 hour:13 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-036 hour:13 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-065 hour:13 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-036 hour:13 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-065 hour:13 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-036 hour:13 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-065 hour:13 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-037 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-066 hour:14 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-037 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-066 hour:14 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-037 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-066 hour:14 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-037 hour:14 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-066 hour:14 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-038 hour:15 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-067 hour:15 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-038 hour:15 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-067 hour:15 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-038 hour:15 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-067 hour:15 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-038 hour:15 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-067 hour:15 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-039 hour:17 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-068 hour:17 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-039 hour:17 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-068 hour:17 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-039 hour:17 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-068 hour:17 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-039 hour:17 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-068 hour:17 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-040 hour:19 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-069 hour:19 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-040 hour:19 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-069 hour:19 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-040 hour:19 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-069 hour:19 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-040 hour:19 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-069 hour:19 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-041 hour:21 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-070 hour:21 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-041 hour:21 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-070 hour:21 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-041 hour:21 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-070 hour:21 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-041 hour:21 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-070 hour:21 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-042 hour:22 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-071 hour:22 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-042 hour:22 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-071 hour:22 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-042 hour:22 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-071 hour:22 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-042 hour:22 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-071 hour:22 | day:day2 | Group:Baseline -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-043 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-072 hour:7 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-043 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-072 hour:7 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-043 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-072 hour:7 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-043 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-072 hour:7 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-044 hour:12 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-073 hour:12 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-044 hour:12 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-073 hour:12 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-044 hour:12 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-073 hour:12 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-044 hour:12 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-073 hour:12 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-045 hour:15 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-074 hour:15 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-045 hour:15 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-074 hour:15 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-045 hour:15 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-074 hour:15 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-045 hour:15 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-074 hour:15 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-046 hour:21 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-075 hour:21 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-046 hour:21 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-075 hour:21 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-046 hour:21 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-075 hour:21 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-046 hour:21 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-075 hour:21 | day:day3 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-047 hour:3 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-076 hour:3 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-047 hour:3 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-076 hour:3 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-047 hour:3 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-076 hour:3 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-047 hour:3 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-076 hour:3 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-048 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-077 hour:6 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-048 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-077 hour:6 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-048 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-077 hour:6 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-048 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-077 hour:6 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-049 hour:9 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-078 hour:9 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-049 hour:9 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-078 hour:9 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-049 hour:9 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-078 hour:9 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-049 hour:9 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-078 hour:9 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-050 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-079 hour:13 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-050 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-079 hour:13 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-050 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-079 hour:13 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-050 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-079 hour:13 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-051 hour:17 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-080 hour:17 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-051 hour:17 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-080 hour:17 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-051 hour:17 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-080 hour:17 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-051 hour:17 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-080 hour:17 | day:day4 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-053 hour:3 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-082 hour:3 | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-053 hour:3 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-082 hour:3 | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-053 hour:3 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-082 hour:3 | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-053 hour:3 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-082 hour:3 | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-054 hour:6 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-083 hour:6 | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-054 hour:6 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-083 hour:6 | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-054 hour:6 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-083 hour:6 | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-054 hour:6 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-083 hour:6 | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A nC18-11aug17-052 hour:- | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nC18-15aug17-081 hour:- | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3634A nhilic-08aug17-052 hour:- | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A nhilic-10aug17-081 hour:- | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3634A pC18-09aug17-052 hour:- | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A pC18-14aug17-081 hour:- | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3634A philic-07aug17-052 hour:- | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3634A philic-09aug17-081 hour:- | day:day5 | Group:CR -80 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-001 hour:11 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-001 hour:11 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-001 hour:11 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-001 hour:11 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-002 hour:13 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-002 hour:13 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-002 hour:13 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-002 hour:13 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-003 hour:16 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-003 hour:16 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-003 hour:16 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-003 hour:16 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-004 hour:19 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-004 hour:19 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-004 hour:19 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-004 hour:19 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-005 hour:22 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-005 hour:22 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-005 hour:22 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-005 hour:22 | day:day1 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-006 hour:8 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-006 hour:8 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-006 hour:8 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-006 hour:8 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-007 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-007 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-007 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-007 hour:11 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-008 hour:13 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-008 hour:13 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-008 hour:13 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-008 hour:13 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-009 hour:16 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-009 hour:16 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-009 hour:16 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-009 hour:16 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-010 hour:18 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-010 hour:18 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-010 hour:18 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-010 hour:18 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-011 hour:20 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-011 hour:20 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-011 hour:20 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-011 hour:20 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-012 hour:22 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-012 hour:22 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-012 hour:22 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-012 hour:22 | day:day2 | Group:Baseline -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-013 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-013 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-013 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-013 hour:7 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-014 hour:10 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-014 hour:10 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-014 hour:10 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-014 hour:10 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-015 hour:13 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-015 hour:13 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-015 hour:13 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-015 hour:13 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-016 hour:16 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-016 hour:16 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-016 hour:16 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-016 hour:16 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-017 hour:19 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-017 hour:19 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-017 hour:19 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-017 hour:19 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-018 hour:22 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-018 hour:22 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-018 hour:22 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-018 hour:22 | day:day3 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-019 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-019 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-019 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-019 hour:6 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-020 hour:10 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-020 hour:10 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-020 hour:10 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-020 hour:10 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-021 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-021 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-021 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-021 hour:13 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-022 hour:16 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-022 hour:16 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-022 hour:16 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-022 hour:16 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-023 hour:19 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-023 hour:19 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-023 hour:19 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-023 hour:19 | day:day4 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-024 hour:- | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-024 hour:- | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-024 hour:- | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-024 hour:- | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic SUBJECT_SAMPLE_FACTORS 3635A nC18-05aug17-025 hour:7 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nC18 SUBJECT_SAMPLE_FACTORS 3635A nhilic-05aug17-025 hour:7 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=nhilic SUBJECT_SAMPLE_FACTORS 3635A pC18-04aug17-025 hour:7 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=pC18 SUBJECT_SAMPLE_FACTORS 3635A philic-04aug17-025 hour:7 | day:day5 | Group:CR -20 storage Type=Urine; sex=F; chormatography=philic #COLLECTION CO:COLLECTION_SUMMARY Serial urine samples were collected at each void (approximately every 3 hours) CO:COLLECTION_SUMMARY from subjects during a 6-day inpatient protocol. The total volume of each sample CO:COLLECTION_SUMMARY was measured, and then 5 mL was aliquoted into a 7 mL tube and delivered on ice CO:COLLECTION_SUMMARY to the processing lab, where the samples were then stored at -80 degrees. At the CO:COLLECTION_SUMMARY end of the study, samples were transported (~2 blocks) from the processing lab CO:COLLECTION_SUMMARY to our -80 freezer for storage. CO:SAMPLE_TYPE Urine #TREATMENT TR:TREATMENT_SUMMARY This subject (subject code: 3635A) spent 6 days in the lab: 3 baseline days TR:TREATMENT_SUMMARY where the subject slept for 8 hours at night (at habitual times as determined TR:TREATMENT_SUMMARY during the screening period) and 16 hours of ambulatory wake in ambient light, TR:TREATMENT_SUMMARY followed by 50 hours of continuous wakefulness in which the subject was kept in TR:TREATMENT_SUMMARY a semi-recumbent position in bed under dim light and fed hourly isocaloric TR:TREATMENT_SUMMARY snacks (called a "constant routine"). In the study design, baseline and CR are TR:TREATMENT_SUMMARY used to group the 3 day baseline days and constant routine days. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY large scale profiling #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Agilent 1290 Infinity CH:COLUMN_NAME Waters Acquity BEH Amide (150 x 2.1mm, 1.7um) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Agilent 6550 QTOF MS:INSTRUMENT_TYPE QTOF MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_RESULTS_FILE ST001002_AN001637_Results.txt UNITS:intensity #END