{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001160","ANALYSIS_ID":"AN001918","VERSION":"1","CREATED_ON":"03-03-2022"},

"PROJECT":{"PROJECT_TITLE":"Nonhuman primate (NHP) radiation metabolomics","PROJECT_SUMMARY":"Here, we use global metabolomics to differentiate temporal effects (1 – 60 d) found in nonhuman primate (NHP) urine small molecule signatures after a 4 Gy total body irradiation.","INSTITUTE":"Georgetown University","LAST_NAME":"Pannkuk","FIRST_NAME":"Evan","ADDRESS":"3970 Reservoir Rd, NW New Research Build, washington dc, District of Columbia, 20057, USA","EMAIL":"elp44@georgetown.edu","PHONE":"2026875650","DOI":"http://dx.doi.org/10.21228/M8P09H"},

"STUDY":{"STUDY_TITLE":"Targeted NHP serum metabolomics (part-III)","STUDY_SUMMARY":"Here, we use global metabolomics to differentiate temporal effects (1 – 60 d) found in nonhuman primate (NHP) serum small molecule signatures after a 4 Gy total body irradiation.","INSTITUTE":"Georgetown University","LAST_NAME":"Pannkuk","FIRST_NAME":"Evan","ADDRESS":"3970 Reservoir Rd, NW New Research Build","EMAIL":"elp44@georgetown.edu","PHONE":"2026875650","SUBMIT_DATE":"2019-02-28"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Macaca mulatta","TAXONOMY_ID":"9544"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"NHP25",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP26",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP27",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP28",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP29",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP30",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP31",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP32",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP33",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP34",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP35",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP36",
"Factors":{"Treatment":"control_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP1",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP10",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP11",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP12",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP13",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP14",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP15",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP16",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP2",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP3",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP4",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP5",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP6",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP7",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP8",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP9",
"Factors":{"Treatment":"control_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP37",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP38",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP39",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP40",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP41",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP42",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP43",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP44",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP45",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP46",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP47",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP48",
"Factors":{"Treatment":"exp_training"}
},
{
"Subject ID":"-",
"Sample ID":"NHP17",
"Factors":{"Treatment":"exp_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP18",
"Factors":{"Treatment":"exp_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP19",
"Factors":{"Treatment":"exp_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP20",
"Factors":{"Treatment":"exp_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP21",
"Factors":{"Treatment":"exp_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP22",
"Factors":{"Treatment":"exp_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP23",
"Factors":{"Treatment":"exp_validation"}
},
{
"Subject ID":"-",
"Sample ID":"NHP24",
"Factors":{"Treatment":"exp_validation"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"None","SAMPLE_TYPE":"Blood (serum)"},

"TREATMENT":{"TREATMENT_SUMMARY":"4 Gy at 0.6 Gy/min with a 60Co γ source"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Serum (5 μl) was diluted with 200 μl cold methanol:acetonitrile:water (80:15:5) spiked with internal standards, vortexed, placed on ice for 10 min, and centrifuged for 10 min (10,000 x g, 4°C)"},

"CHROMATOGRAPHY":{"INSTRUMENT_NAME":"Waters ACQUITY UPLC","COLUMN_NAME":"Acquity BEH amide 1.7 μm 2.1 x 100 mm","CHROMATOGRAPHY_TYPE":"HILIC"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Waters Xevo-TQ-S","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","MS_COMMENTS":"None","ION_MODE":"UNSPECIFIED"},

"MS_METABOLITE_DATA":{
"Units":"ng/ml",

"Data":[{"Metabolite":"carnitine","NHP25":"27.1000","NHP26":"47.4000","NHP27":"15.2000","NHP28":"29.1000","NHP29":"33.7000","NHP30":"9.2000","NHP31":"24.7000","NHP32":"28.8000","NHP33":"10.4000","NHP34":"7.7000","NHP35":"9.8000","NHP36":"10.8000","NHP1":"33.7000","NHP10":"19.2000","NHP11":"2.4000","NHP12":"24.9000","NHP13":"15.3000","NHP14":"17.7000","NHP15":"58.0000","NHP16":"3.9000","NHP2":"4.0000","NHP3":"9.9000","NHP4":"27.0000","NHP5":"22.6000","NHP6":"12.8000","NHP7":"7.8000","NHP8":"44.7000","NHP9":"16.1000","NHP37":"16.8000","NHP38":"19.4000","NHP39":"34.8000","NHP40":"26.5000","NHP41":"26.2000","NHP42":"29.1000","NHP43":"27.7000","NHP44":"27.4000","NHP45":"51.9000","NHP46":"76.3000","NHP47":"52.2000","NHP48":"","NHP17":"53.9000","NHP18":"41.3000","NHP19":"45.6000","NHP20":"70.8000","NHP21":"14.1000","NHP22":"41.2000","NHP23":"25.1000","NHP24":"13.1000"},{"Metabolite":"hypoxanthine","NHP25":"11.9000","NHP26":"13.8000","NHP27":"8.8000","NHP28":"18.7000","NHP29":"10.5000","NHP30":"16.4000","NHP31":"17.5000","NHP32":"9.7000","NHP33":"10.7000","NHP34":"12.0000","NHP35":"13.4000","NHP36":"8.9000","NHP1":"13.5000","NHP10":"12.6000","NHP11":"11.6000","NHP12":"9.4000","NHP13":"10.4000","NHP14":"14.9000","NHP15":"15.0000","NHP16":"9.7000","NHP2":"13.9000","NHP3":"13.2000","NHP4":"8.7000","NHP5":"15.1000","NHP6":"19.0000","NHP7":"10.8000","NHP8":"8.2000","NHP9":"11.9000","NHP37":"2.1000","NHP38":"8.8000","NHP39":"4.5000","NHP40":"5.4000","NHP41":"0.4000","NHP42":"1.5000","NHP43":"2.0000","NHP44":"3.2000","NHP45":"5.9000","NHP46":"4.5000","NHP47":"9.1000","NHP48":"","NHP17":"4.3000","NHP18":"4.3000","NHP19":"11.0000","NHP20":"6.2000","NHP21":"2.4000","NHP22":"4.8000","NHP23":"6.9000","NHP24":"4.1000"},{"Metabolite":"taurine","NHP25":"70.8000","NHP26":"99.4000","NHP27":"63.5000","NHP28":"102.8000","NHP29":"120.5000","NHP30":"91.1000","NHP31":"132.0000","NHP32":"88.4000","NHP33":"103.2000","NHP34":"79.8000","NHP35":"78.6000","NHP36":"52.3000","NHP1":"59.7000","NHP10":"61.6000","NHP11":"69.2000","NHP12":"52.5000","NHP13":"75.6000","NHP14":"65.4000","NHP15":"72.9000","NHP16":"86.6000","NHP2":"56.1000","NHP3":"91.3000","NHP4":"59.6000","NHP5":"74.2000","NHP6":"93.4000","NHP7":"60.7000","NHP8":"72.6000","NHP9":"63.4000","NHP37":"40.5000","NHP38":"59.0000","NHP39":"41.9000","NHP40":"43.9000","NHP41":"33.0000","NHP42":"38.9000","NHP43":"27.4000","NHP44":"35.4000","NHP45":"47.3000","NHP46":"57.3000","NHP47":"45.4000","NHP48":"","NHP17":"47.6000","NHP18":"61.9000","NHP19":"38.0000","NHP20":"54.7000","NHP21":"43.8000","NHP22":"26.7000","NHP23":"74.9000","NHP24":"43.0000"}],

"Metabolites":[{"Metabolite":"carnitine","pubchem_id":"","inchi_key":"","kegg_id":"","other_id":"","other_id_type":"","ri":"","ri_type":"","moverz_quant":"","":""},{"Metabolite":"hypoxanthine","pubchem_id":"","inchi_key":"","kegg_id":"","other_id":"","other_id_type":"","ri":"","ri_type":"","moverz_quant":"","":""},{"Metabolite":"taurine","pubchem_id":"","inchi_key":"","kegg_id":"","other_id":"","other_id_type":"","ri":"","ri_type":"","moverz_quant":"","":""}]
}

}