{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001635","ANALYSIS_ID":"AN002672","VERSION":"1","CREATED_ON":"December 22, 2020, 12:24 pm"},

"PROJECT":{"PROJECT_TITLE":"Higher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer Chemoresistance","PROJECT_TYPE":"C18 Reversed-Phase Broad Spectrum Metabolomics","PROJECT_SUMMARY":"Epidemiologic and experimental studies have established that obesity is an important risk and/or prognostic factor for most cancer types, but the mechanisms underlying the obesity-cancer link have not been clearly elucidated. The goal of this project is to address questions on the mechanisms of (and potential solutions to) obesity that results directly from diet exposures and the associated chemotherapeutic resistance. In a mouse model of basal-like breast cancer (BLBC), we compared a high protein (HP) diet to a high carbohydrate plus high fat (HCHF) diet and determined their comparative impacts on body weight, fatty liver development, tumor growth acute chemotherapy response to doxorubicin, profiled 80 inflammatory markers and performed untargeted metabolomics. Briefly, female C57BL/6 mice were fed either the HP or HCHF diet for 15 weeks, orthotopically implanted with MMTV-Wnt-1 mammary cells for tumor formation and growth (up to six weeks), then treated with a single dose of doxorubicin (or saline vehicle control) for 24 hours prior to study completion. Mice were euthanized and biospecimens were collected at the following study endpoints: 1-baseline (following 1-week quarantine); 2-after the 15 weeks of differential diet exposure; 3-after 5 weeks and 5.5 weeks of tumor growth; and 4-after 24 hours of treatment, corresponding to 6 weeks of tumor growth. Untargeted metabolomics analysis was performed by UPLC high resolution mass spectrometry (LCMS) on liver samples at the four study endpoints described above. Liver tissues were sectioned into three discrete lobes (right, left and median=caudate + quadrate) prior to analysis.","INSTITUTE":"University of North Carolina at Chapel Hill","DEPARTMENT":"Nutrition","LABORATORY":"Metabolomics and Exposome Laboratory, Nutrition Research Institute, UNC Chapel Hill","LAST_NAME":"Stewart","FIRST_NAME":"Delisha","ADDRESS":"500 Laureate Way, Nutrition Research Institute, UNC Chapel Hill","EMAIL":"delisha_stewart@unc.edu","PHONE":"+1 (704) 250-5068"},

"STUDY":{"STUDY_TITLE":"Higher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer Chemoresistance","STUDY_TYPE":"Untargeted UPLC-MS Metabolomics Analysis","STUDY_SUMMARY":"This study is a part of an ongoing project entitled, “Higher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer Chemoresistance.” (See project). Untargeted LCMS metabolomics analysis was performed to identify metabolic markers of nutritionally dependent and obesity-associated chemoresistance in female C57LB/6 mice fed either a high carbohydrate plus high fat (HCHF) diet or a high protein diet (HP). Mice were fed 15 weeks on either diet, then injected with a MMTV-Wnt-1 mouse mammary basal-like breast cancer cell line, for tumor formation up to 6 weeks. Three mice on either diet were treated for 24 hr with Doxorubicin or Saline as a vehicle control. All samples were analyzed in the positive mode for untargeted metabolomics analysis. Liver samples were selected for analysis because of an observation of fatty liver development in mice only on the HCHF diet after 15 weeks. Samples were extracted and analyzed by UPLS-MS analysis using Q-Exactive HFX mass spectrometer.","INSTITUTE":"University of North Carolina at Chapel Hill","DEPARTMENT":"Nutrition","LABORATORY":"Metabolomics and Exposome Laboratory, Nutrition Research Institute, UNC Chapel Hill","LAST_NAME":"Sumner","FIRST_NAME":"Susan","ADDRESS":"500 Laureate Way, Nutrition Research Institute, UNC Chapel Hill","EMAIL":"susan_sumner@unc.edu","PHONE":"(919) 622-4456","NUM_GROUPS":"6","TOTAL_SUBJECTS":"193","NUM_FEMALES":"175","STUDY_COMMENTS":"The number of groups includes the QC samples"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENOTYPE_STRAIN":"C57BL/6","GENDER":"Female","ANIMAL_ANIMAL_SUPPLIER":"Charles River Labs"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"L_1",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_2",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_3",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_3.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_4",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_4.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_5",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_5.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_6",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_6.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_7",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_7.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_8",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_8.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_9",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_9.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_10",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_10.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_11",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_11.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_12",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_12.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_13",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_13.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_14",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_14.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_15",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_15.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_16",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_16.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_17",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_17.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_18",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_18.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_19",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_19.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_20",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_20.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_21",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_21.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_22",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_22.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_23",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_23.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_24",
"Factors":{"Diet":"HP","Study Phenotype":"Baseline","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_24.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_25",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_25.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_26",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_26.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_27",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_27.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_28",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_28.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_29",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_29.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_30",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_30.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_31",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_31.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_32",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_32.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_33",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_33.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_34",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_34.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_35",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_35.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_36",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_36.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_37",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_37.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_38",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_38.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_39",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_39.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_40",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_40.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_41",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_41.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_42",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_42.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_43",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_43.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_44",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_44.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_45",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_45.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_46",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_46.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_47",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_47.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_48",
"Factors":{"Diet":"HCHF","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_48.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_49",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_49.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_50",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_50.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_51",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_51.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_52",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_52.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_53",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_53.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_54",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_54.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_55",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_55.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_56",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_56.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_57",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_57.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_58",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_58.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_59",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_59.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_60",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_60.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_61",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_61.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_62",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_62.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_63",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_63.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_64",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_64.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_65",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_65.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_66",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_66.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_67",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_67.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_68",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_68.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_69",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_69.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_70",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_70.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_71",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_71.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_72",
"Factors":{"Diet":"HP","Study Phenotype":"15 wk Differential Diet","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"None","Sample Type":"Sample","RAW_FILE_NAME":"L_72.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_73",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_73.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_74",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_74.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_75",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_75.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_76",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_76.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_77",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_77.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_78",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_78.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_79",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_79.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_80",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_80.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_81",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_81.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_82",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_82.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_83",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_83.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_84",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_84.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_85",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_85.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_86",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_86.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_87",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_87.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_88",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_88.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_89",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_89.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_90",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_90.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_91",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_91.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_92",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_92.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_93",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_93.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_94",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_94.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_95",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_95.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_96",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_96.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_97",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_97.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_98",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_98.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_99",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_99.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_100",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_100.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_101",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_101.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_103",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_103.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_104",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_104.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_105",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_105.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_106",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_106.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_107",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_107.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_108",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_108.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_109",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_109.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_110",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_110.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_111",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_111.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_112",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_112.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_113",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_113.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_114",
"Factors":{"Diet":"HCHF","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_114.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_115",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_115.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_116",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_116.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_117",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_117.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_118",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_118.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_119",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_119.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_120",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_120.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_121",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_121.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_122",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_122.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_123",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_123.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_124",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_124.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_127",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_127.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_130",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_130.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_131",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_131.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_132",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_132.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_133",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_133.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_134",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_134.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_135",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_135.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_136",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_136.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_137",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_137.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_138",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_138.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_139",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_139.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_140",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_140.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_141",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_141.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_142",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_142.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_143",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_143.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_144",
"Factors":{"Diet":"HP","Study Phenotype":"Tumor Growth-5.5 wk","Treatment":"None","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_144.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_145",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_145.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_146",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_146.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_147",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_147.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_148",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_148.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_149",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_149.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_150",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_150.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_151",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_151.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_152",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_152.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_153",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_153.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_154",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_154.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_155",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_155.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_156",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_156.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_157",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_157.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_158",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_158.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_159",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_159.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_160",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_160.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_161",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_161.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_162",
"Factors":{"Diet":"HCHF","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_162.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_163",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_163.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_164",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_164.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_165",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_165.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_166",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_166.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_167",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_167.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_168",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_168.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_169",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_169.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_170",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_170.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_171",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"DOX-treated","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_171.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_172",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_172.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_173",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_173.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_174",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_174.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_175",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_175.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_176",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_176.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_177",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_177.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_178",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Right"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_178.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_179",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Left"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_179.raw"}
},
{
"Subject ID":"-",
"Sample ID":"L_180",
"Factors":{"Diet":"HP","Study Phenotype":"24 hr Treatment","Treatment":"Saline-control","Liver Lobe":"Median"},
"Additional sample data":{"Cell Line Injected":"BLBC","Sample Type":"Sample","RAW_FILE_NAME":"L_180.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_1-4",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_1-4.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_2-1",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_2-1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_2-2",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_2-2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_3-1",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_3-1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_3-2",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_3-2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_4-1",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_4-1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_4-2",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_4-2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_5-1",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_5-1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_5-2",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_5-2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_6-4",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_6-4.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_7-1",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_7-1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_7-2",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_7-2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_8-1",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_8-1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_8-2",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_8-2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_9-1",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_9-1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_9-2",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_9-2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_10-1",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_10-1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"SP_10-2",
"Factors":{"Diet":"-","Study Phenotype":"Pooled","Treatment":"-","Liver Lobe":"-"},
"Additional sample data":{"Cell Line Injected":"-","Sample Type":"QC","RAW_FILE_NAME":"SP_10-2.raw"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"See the project foe more details. Briefly, mice were euthanized and biospecimens were collected at the following study endpoints: 1-baseline (following 1-week quarantine); 2-after the 15 weeks of differential diet exposure; 3-after 5 weeks and 5.5 weeks of tumor growth; and 4-after 24 hours of treatment, corresponding to 6 weeks of tumor growth.","SAMPLE_TYPE":"Liver","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"24 hr single dose treatment with Doxorubicin or saline (vehicle control). See project for more details.","TREATMENT_DOSE":"10 mg/kg","TREATMENT_DOSEVOLUME":"100 uL","TREATMENT_DOSEDURATION":"24 hr","TREATMENT_VEHICLE":"saline"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Liver tissue samples were put into randomized order (n=60), then were weighed then sectioned into three lobes (on dry ice) prior to analyses. Tissues were sectioned into the Right lobe, Left lobe and Median lobe (comprised of the caudate+quadrate lobes). Individual lobe weights were measured, then each lobe was further sectioned into equal numbers of cubes (4-6 cubes/lobe), depending on the lobe size. Two-three smaller cubes, were recombined into a new tube, weighed and used for metabolomics analysis. Two mice (HP diet, 5.5 weeks of tumor growth) were missing both left and median lobes from their gross liver tissues, and one mouse (HCHF diet, 5.5 weeks of tumor growth) was missing the median lobe; thus these samples were not included for metabolomics analysis. Thus, the total number of experimental samples was 175 rather than 180.","PROCESSING_METHOD":"Sectioned and weighed frozen liver tissue samples (n=175, 60-450 mg) were homogenized with cold methanol (10 µl for every mg of tissue) in a Bead Ruptor Elite Bead Mill Homogenizer (OMNI International) at 5.0 m/s for 30 s in two cycles. The supernatants were collected after centrifugation at 16,000 rcf for 20 min at 4 °C. A quality control pool (QC pool) sample was prepared by pooling 30 µL supernatant aliquots from selected individual samples (n=78), with a total pre-processing weight ≥ 60 mg. The supernatants (200 µL) of each study sample and QC pools were transferred to new tubes and dried under Speed-vac. Each dried sample was reconstituted in a 200 µL water-methanol (95:5) solution containing 500 ng/ml L-tryphotophan-d5. The samples were thoroughly mixed on multiple tube vortexer for 10 mins at 5000 rpm. Samples were centrifuged at room temperature and at 16,000 rcf for 4 min. The supernatant was transferred to pre-labeled auto-sampler vials for data acquisition. Untargeted metabolomics was conducted using a Thermo Scientific™ Vanquish™ UPHPLC - Q Exactive™ HF-X Orbitrap System. Metabolites were separated on an Acquity UPLC HSS T3 C18 (2.1 X 100 mm, 1.8 µm) operating at 50 °C using a reversed phase gradient separation with Water with 0.1% Formic Acid (v/v) as mobile phase A and Methanol with 0.1% Formic Acid (v/v) as mobile phase B. A 5 µL amount was injected into the instrument, and MS data was collected between 50-750 m/z in the positive mode with the MS/MS data triggered by the Data-Dependent Acquisition.","PROCESSING_STORAGE_CONDITIONS":"4℃","EXTRACT_STORAGE":"-80℃"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"None","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Thermo Vanquish","COLUMN_NAME":"Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um)","FLOW_RATE":"0.4 mL/min","COLUMN_TEMPERATURE":"8","SOLVENT_A":"Water with 0.1% Formic Acid","SOLVENT_B":"Methanol with 0.1% Formic Acid","COLUMN_PRESSURE":"6000-10000","INJECTION_TEMPERATURE":"8","WEAK_WASH_SOLVENT_NAME":"10:90 Methanol:Water with 0.1% FA solution","STRONG_WASH_SOLVENT_NAME":"75:25 2-Propanol: Water with 0.1% FA solution","RANDOMIZATION_ORDER":"Yes","CHROMATOGRAPHY_COMMENTS":"Time(min) Flow Rate %A %B Curve 1. 0 0.4 99.0 1.0 5 2. 1.00 0.4 99.0 1.0 5 3. 16.00 0.4 1.0 99.0 5 4. 19.00 0.4 1.0 99.0 5 5. 19.50 0.4 99.0 1.0 5"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","LABORATORY_NAME":"UNC-NRI Sumner lab","OPERATOR_NAME":"Yuanyuan Li","DETECTOR_TYPE":"Orbitrap","SOFTWARE_VERSION":"Xcalibur 4.1","DATA_FORMAT":"profile"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive HF hybrid Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"NA","CAPILLARY_TEMPERATURE":"275 °C","CAPILLARY_VOLTAGE":"3.5 KV","COLLISION_ENERGY":"10-35, ramp","COLLISION_GAS":"N2","DRY_GAS_FLOW":"45","DRY_GAS_TEMP":"325°C","FRAGMENTATION_METHOD":"CID","DESOLVATION_GAS_FLOW":"45","MS_RESULTS_FILE":"ST001635_AN002672_Results.txt UNITS:peak area Has m/z:Yes Has RT:Yes RT units:Minutes"}

}