#METABOLOMICS WORKBENCH bifarin_20210211_060901 DATATRACK_ID:2473 STUDY_ID:ST001705 ANALYSIS_ID:AN002778 PROJECT_ID:PR001091 VERSION 1 CREATED_ON February 22, 2021, 10:06 am #PROJECT PR:PROJECT_TITLE Machine learning-enabled renal cell carcinoma status prediction using PR:PROJECT_TITLE multi-platform urine-based metabolomics PR:PROJECT_TYPE multi-platform urine-based metabolomics PR:PROJECT_SUMMARY Currently, Renal Cell Carcinoma (RCC) is identified through expensive PR:PROJECT_SUMMARY cross-sectional imaging, frequently followed by renal mass biopsy, which is PR:PROJECT_SUMMARY invasive and subject to sampling errors. Hence, there is a critical need for a PR:PROJECT_SUMMARY non-invasive diagnostic assay. RCC is a disease of altered cellular metabolism PR:PROJECT_SUMMARY with the tumor(s) in close proximity to the urine in the kidney suggesting PR:PROJECT_SUMMARY metabolomic profiling would be an excellent choice for assay development. Here, PR:PROJECT_SUMMARY we applied liquid chromatography-mass spectrometry (LC-MS), nuclear magnetic PR:PROJECT_SUMMARY resonance (NMR), and machine learning (ML) for the discovery of candidate PR:PROJECT_SUMMARY metabolic panels for RCC. The study cohort consists of 82 RCC patients and 174 PR:PROJECT_SUMMARY healthy controls, these were separated into two sub-cohorts: model cohort and PR:PROJECT_SUMMARY the test cohort. Discriminatory metabolic features were selected in the model PR:PROJECT_SUMMARY cohort, using univariate, wrapper, and embedded methods of feature selection. PR:PROJECT_SUMMARY Three ML techniques with different induction biases were used for training and PR:PROJECT_SUMMARY hyperparameter tuning. Final assessment of RCC status prediction was made using PR:PROJECT_SUMMARY the test cohort with the selected biomarkers and the tuned ML algorithms. A PR:PROJECT_SUMMARY seven-metabolite panel consisting of endogenous and exogenous metabolites PR:PROJECT_SUMMARY enabled the prediction of RCC with 88% accuracy, 94% sensitivity, and 85% PR:PROJECT_SUMMARY specificity in the test cohort, with an AUC of 0.98. PR:INSTITUTE University of Georgia PR:DEPARTMENT Biochemistry and Molecular Biology PR:LABORATORY Edison Lab PR:LAST_NAME Bifarin PR:FIRST_NAME Olatomiwa PR:ADDRESS 315 Riverbend Rd, Athens, GA 30602 PR:EMAIL olatomiwa.bifarin25@uga.edu PR:PHONE (706) 542-4401 Lab: 1045 #STUDY ST:STUDY_TITLE Machine learning-enabled renal cell carcinoma status prediction using ST:STUDY_TITLE multi-platform urine-based metabolomics ST:STUDY_SUMMARY Currently, Renal Cell Carcinoma (RCC) is identified through expensive ST:STUDY_SUMMARY cross-sectional imaging, frequently followed by renal mass biopsy, which is ST:STUDY_SUMMARY invasive and subject to sampling errors. Hence, there is a critical need for a ST:STUDY_SUMMARY non-invasive diagnostic assay. RCC is a disease of altered cellular metabolism ST:STUDY_SUMMARY with the tumor(s) in close proximity to the urine in the kidney suggesting ST:STUDY_SUMMARY metabolomic profiling would be an excellent choice for assay development. Here, ST:STUDY_SUMMARY we applied liquid chromatography-mass spectrometry (LC-MS), nuclear magnetic ST:STUDY_SUMMARY resonance (NMR), and machine learning (ML) for the discovery of candidate ST:STUDY_SUMMARY metabolic panels for RCC. The study cohort consists of 82 RCC patients and 174 ST:STUDY_SUMMARY healthy controls, these were separated into two sub-cohorts: model cohort and ST:STUDY_SUMMARY the test cohort. Discriminatory metabolic features were selected in the model ST:STUDY_SUMMARY cohort, using univariate, wrapper, and embedded methods of feature selection. ST:STUDY_SUMMARY Three ML techniques with different induction biases were used for training and ST:STUDY_SUMMARY hyperparameter tuning. Final assessment of RCC status prediction was made using ST:STUDY_SUMMARY the test cohort with the selected biomarkers and the tuned ML algorithms. A ST:STUDY_SUMMARY seven-metabolite panel consisting of endogenous and exogenous metabolites ST:STUDY_SUMMARY enabled the prediction of RCC with 88% accuracy, 94% sensitivity, and 85% ST:STUDY_SUMMARY specificity in the test cohort, with an AUC of 0.98. ST:INSTITUTE University of Georgia ST:DEPARTMENT Department of Biochemistry and Molecular Biology ST:LABORATORY Edison Lab ST:LAST_NAME Bifarin ST:FIRST_NAME Olatomiwa ST:ADDRESS 315 Riverbend Rd, Athens, GA 30602 ST:EMAIL olatomiwa.bifarin25@uga.edu ST:PHONE 757-405-4379 ST:NUM_GROUPS Two #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #FACTORS #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - C001 SampleType:RCC RAW_FILE_NAME=C001; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=24.4; Smoker=Never; Age=38.1 SUBJECT_SAMPLE_FACTORS - C002 SampleType:RCC RAW_FILE_NAME=C002; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=30.6; Smoker=Never; Age=64.9 SUBJECT_SAMPLE_FACTORS - C003 SampleType:RCC RAW_FILE_NAME=C003; Sample description=Chromophobe carcinoma; Gender=Male; Race=White; BMI=34.2; Smoker=Never; Age=64 SUBJECT_SAMPLE_FACTORS - C004 SampleType:RCC RAW_FILE_NAME=C004; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=24.7; Smoker=Never; Age=84.8 SUBJECT_SAMPLE_FACTORS - C005 SampleType:RCC RAW_FILE_NAME=C005; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=32.2; Smoker=Former; Age=55.7 SUBJECT_SAMPLE_FACTORS - C006 SampleType:RCC RAW_FILE_NAME=C006; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=27.8; Smoker=Never; Age=59 SUBJECT_SAMPLE_FACTORS - C007 SampleType:RCC RAW_FILE_NAME=C007; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=32.2; Smoker=Never; Age=44.7 SUBJECT_SAMPLE_FACTORS - C009 SampleType:RCC RAW_FILE_NAME=C009; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=27.2; Smoker=Never; Age=50.8 SUBJECT_SAMPLE_FACTORS - C011 SampleType:RCC RAW_FILE_NAME=C011; Sample description=Sarcomatoid; Gender=Female; Race=White; BMI=23.9; Smoker=Never; Age=74.5 SUBJECT_SAMPLE_FACTORS - C012 SampleType:RCC RAW_FILE_NAME=C012; Sample description=Papillary RCC; Gender=Male; Race=White; BMI=27.2; Smoker=Former; Age=77.4 SUBJECT_SAMPLE_FACTORS - C013 SampleType:RCC RAW_FILE_NAME=C013; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=American-Indian/Alaskan-Native; BMI=25; Smoker=Never; Age=46.2 SUBJECT_SAMPLE_FACTORS - C014 SampleType:RCC RAW_FILE_NAME=C014; Sample description=Sarcomatoid; Gender=Male; Race=White; BMI=35.4; Smoker=Never; Age=60.9 SUBJECT_SAMPLE_FACTORS - C015 SampleType:RCC RAW_FILE_NAME=C015; Sample description=Sarcomatoid; Gender=Male; Race=White; BMI=21.8; Smoker=Never; Age=45.2 SUBJECT_SAMPLE_FACTORS - C016 SampleType:RCC RAW_FILE_NAME=C016; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=32.5; Smoker=Current; Age=35.1 SUBJECT_SAMPLE_FACTORS - C018 SampleType:RCC RAW_FILE_NAME=C018; Sample description=Chromophobe carcinoma; Gender=Female; Race=Black/AA; BMI=24.9; Smoker=Never; Age=56 SUBJECT_SAMPLE_FACTORS - C019 SampleType:RCC RAW_FILE_NAME=C019; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=37.3; Smoker=Never; Age=58.8 SUBJECT_SAMPLE_FACTORS - C020 SampleType:RCC RAW_FILE_NAME=C020; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Black/AA; BMI=41; Smoker=Former; Age=72.9 SUBJECT_SAMPLE_FACTORS - C021 SampleType:RCC RAW_FILE_NAME=C021; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=31; Smoker=Former; Age=76.6 SUBJECT_SAMPLE_FACTORS - C022 SampleType:RCC RAW_FILE_NAME=C022; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=38.4; Smoker=Former; Age=55.1 SUBJECT_SAMPLE_FACTORS - C024 SampleType:RCC RAW_FILE_NAME=C024; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=36.4; Smoker=Never; Age=52.8 SUBJECT_SAMPLE_FACTORS - C025 SampleType:RCC RAW_FILE_NAME=C025; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=23.5; Smoker=Never; Age=67 SUBJECT_SAMPLE_FACTORS - C026 SampleType:RCC RAW_FILE_NAME=C026; Sample description=Sarcomatoid; Gender=Female; Race=White; BMI=23.9; Smoker=Never; Age=59.4 SUBJECT_SAMPLE_FACTORS - C027 SampleType:RCC RAW_FILE_NAME=C027; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=26.7; Smoker=Former; Age=55.8 SUBJECT_SAMPLE_FACTORS - C028 SampleType:RCC RAW_FILE_NAME=C028; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=31.7; Smoker=Former; Age=68.8 SUBJECT_SAMPLE_FACTORS - C030 SampleType:RCC RAW_FILE_NAME=C030; Sample description=Cancer (Other); Gender=Male; Race=White; BMI=18.2; Smoker=Current; Age=67.7 SUBJECT_SAMPLE_FACTORS - C031 SampleType:RCC RAW_FILE_NAME=C031; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=26.4; Smoker=Never; Age=69.5 SUBJECT_SAMPLE_FACTORS - C033 SampleType:RCC RAW_FILE_NAME=C033; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Unk/Missing; BMI=30.2; Smoker=Never; Age=31 SUBJECT_SAMPLE_FACTORS - C034 SampleType:RCC RAW_FILE_NAME=C034; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=28.1; Smoker=Former; Age=56 SUBJECT_SAMPLE_FACTORS - C036 SampleType:RCC RAW_FILE_NAME=C036; Sample description=Clear Cell Papillary; Gender=Female; Race=Black/AA; BMI=37.1; Smoker=Never; Age=53 SUBJECT_SAMPLE_FACTORS - C037 SampleType:RCC RAW_FILE_NAME=C037; Sample description=Papillary RCC; Gender=Male; Race=Black/AA; BMI=31; Smoker=Never; Age=55.6 SUBJECT_SAMPLE_FACTORS - C038 SampleType:RCC RAW_FILE_NAME=C038; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=34; Smoker=Former; Age=77.1 SUBJECT_SAMPLE_FACTORS - C039 SampleType:RCC RAW_FILE_NAME=C039; Sample description=Chromophobe carcinoma; Gender=Male; Race=White; BMI=30; Smoker=Never; Age=80.1 SUBJECT_SAMPLE_FACTORS - C040 SampleType:RCC RAW_FILE_NAME=C040; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=33.3; Smoker=Former; Age=62.5 SUBJECT_SAMPLE_FACTORS - C041 SampleType:RCC RAW_FILE_NAME=C041; Sample description=Cancer (Other); Gender=Male; Race=White; BMI=33.6; Smoker=Former; Age=65.6 SUBJECT_SAMPLE_FACTORS - C043 SampleType:RCC RAW_FILE_NAME=C043; Sample description=Sarcomatoid; Gender=Female; Race=White; BMI=38.5; Smoker=Never; Age=58.3 SUBJECT_SAMPLE_FACTORS - C044 SampleType:RCC RAW_FILE_NAME=C044; Sample description=Cancer (Other); Gender=Female; Race=Black/AA; BMI=29.4; Smoker=Never; Age=66.6 SUBJECT_SAMPLE_FACTORS - C045 SampleType:RCC RAW_FILE_NAME=C045; Sample description=Sarcomatoid; Gender=Male; Race=Black/AA; BMI=29.5; Smoker=Never; Age=42.5 SUBJECT_SAMPLE_FACTORS - C046 SampleType:RCC RAW_FILE_NAME=C046; Sample description=Chromophobe carcinoma; Gender=Female; Race=White; BMI=27.4; Smoker=Former; Age=55.4 SUBJECT_SAMPLE_FACTORS - C047 SampleType:RCC RAW_FILE_NAME=C047; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=32.7; Smoker=Former; Age=82.9 SUBJECT_SAMPLE_FACTORS - C048 SampleType:RCC RAW_FILE_NAME=C048; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=31; Smoker=Former; Age=72.4 SUBJECT_SAMPLE_FACTORS - C049 SampleType:RCC RAW_FILE_NAME=C049; Sample description=Sarcomatoid; Gender=Male; Race=White; BMI=36.3; Smoker=Never; Age=64.2 SUBJECT_SAMPLE_FACTORS - C050 SampleType:RCC RAW_FILE_NAME=C050; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Asian; BMI=15.7; Smoker=Never; Age=73 SUBJECT_SAMPLE_FACTORS - C051 SampleType:RCC RAW_FILE_NAME=C051; Sample description=Cancer (Other); Gender=Male; Race=White; BMI=23; Smoker=Never; Age=30.2 SUBJECT_SAMPLE_FACTORS - C052 SampleType:RCC RAW_FILE_NAME=C052; Sample description=Clear Cell Papillary; Gender=Female; Race=Unk/Missing; BMI=45; Smoker=Former; Age=64.5 SUBJECT_SAMPLE_FACTORS - C053 SampleType:RCC RAW_FILE_NAME=C053; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=42.1; Smoker=Former; Age=68.2 SUBJECT_SAMPLE_FACTORS - C054 SampleType:RCC RAW_FILE_NAME=C054; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=24.4; Smoker=Never; Age=67.8 SUBJECT_SAMPLE_FACTORS - C057 SampleType:RCC RAW_FILE_NAME=C057; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=35.2; Smoker=Never; Age=60.5 SUBJECT_SAMPLE_FACTORS - C058 SampleType:RCC RAW_FILE_NAME=C058; Sample description=Papillary RCC; Gender=Male; Race=Black/AA; BMI=24.7; Smoker=Former; Age=83.7 SUBJECT_SAMPLE_FACTORS - C059 SampleType:RCC RAW_FILE_NAME=C059; Sample description=Sarcomatoid; Gender=Male; Race=White; BMI=27.7; Smoker=Former; Age=75.5 SUBJECT_SAMPLE_FACTORS - C060 SampleType:RCC RAW_FILE_NAME=C060; Sample description=Sarcomatoid; Gender=Male; Race=Mixed; BMI=24.9; Smoker=Never; Age=43.3 SUBJECT_SAMPLE_FACTORS - C061 SampleType:RCC RAW_FILE_NAME=C061; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=21.1; Smoker=Never; Age=47.2 SUBJECT_SAMPLE_FACTORS - C062 SampleType:RCC RAW_FILE_NAME=C062; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=31; Smoker=Never; Age=76.4 SUBJECT_SAMPLE_FACTORS - C063 SampleType:RCC RAW_FILE_NAME=C063; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=25.7; Smoker=Never; Age=61.9 SUBJECT_SAMPLE_FACTORS - C064 SampleType:RCC RAW_FILE_NAME=C064; Sample description=Sarcomatoid; Gender=Male; Race=White; BMI=18.5; Smoker=Never; Age=55.6 SUBJECT_SAMPLE_FACTORS - C065 SampleType:RCC RAW_FILE_NAME=C065; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=29.4; Smoker=Current; Age=67 SUBJECT_SAMPLE_FACTORS - C066 SampleType:RCC RAW_FILE_NAME=C066; Sample description=Cancer (Other); Gender=Female; Race=Black/AA; BMI=17.4; Smoker=Current; Age=56.6 SUBJECT_SAMPLE_FACTORS - C070 SampleType:RCC RAW_FILE_NAME=C070; Sample description=Papillary RCC; Gender=Female; Race=Black/AA; BMI=31.3; Smoker=Former; Age=76.2 SUBJECT_SAMPLE_FACTORS - C072 SampleType:RCC RAW_FILE_NAME=C072; Sample description=Chromophobe carcinoma; Gender=Female; Race=White; BMI=29.7; Smoker=Never; Age=36.7 SUBJECT_SAMPLE_FACTORS - C073 SampleType:RCC RAW_FILE_NAME=C073; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=38; Smoker=Never; Age=62.1 SUBJECT_SAMPLE_FACTORS - C074 SampleType:RCC RAW_FILE_NAME=C074; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=31; Smoker=Never; Age=74.9 SUBJECT_SAMPLE_FACTORS - C076 SampleType:RCC RAW_FILE_NAME=C076; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=31; Smoker=Never; Age=71.7 SUBJECT_SAMPLE_FACTORS - C077 SampleType:RCC RAW_FILE_NAME=C077; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=25; Smoker=Former; Age=69.2 SUBJECT_SAMPLE_FACTORS - C078 SampleType:RCC RAW_FILE_NAME=C078; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=25; Smoker=Former; Age=81.1 SUBJECT_SAMPLE_FACTORS - C079 SampleType:RCC RAW_FILE_NAME=C079; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Black/AA; BMI=29; Smoker=Never; Age=45.8 SUBJECT_SAMPLE_FACTORS - C081 SampleType:RCC RAW_FILE_NAME=C081; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; BMI=30.9; Smoker=Never; Age=61.2 SUBJECT_SAMPLE_FACTORS - C082 SampleType:RCC RAW_FILE_NAME=C082; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Black/AA; BMI=30.7; Smoker=Never; Age=59.8 SUBJECT_SAMPLE_FACTORS - C083 SampleType:RCC RAW_FILE_NAME=C083; Sample description=Cancer (Other); Gender=Male; Race=Black/AA; BMI=29; Smoker=Former; Age=76.7 SUBJECT_SAMPLE_FACTORS - C084 SampleType:RCC RAW_FILE_NAME=C084; Sample description=Cancer (Other); Gender=Male; Race=White; BMI=30.6; Smoker=Never; Age=60.4 SUBJECT_SAMPLE_FACTORS - C085 SampleType:RCC RAW_FILE_NAME=C085; Sample description=Cancer (Other); Gender=-; Race=-; BMI=21.5; Smoker=Never; Age=80 SUBJECT_SAMPLE_FACTORS - C086 SampleType:RCC RAW_FILE_NAME=C086; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; BMI=26.2; Smoker=Never; Age=52.3 SUBJECT_SAMPLE_FACTORS - C087 SampleType:RCC RAW_FILE_NAME=C087; Sample description=Cancer (Other); Gender=Female; Race=Black/AA; BMI=23.6; Smoker=Current; Age=60.3 SUBJECT_SAMPLE_FACTORS - C088 SampleType:RCC RAW_FILE_NAME=C088; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Black/AA; BMI=31.4; Smoker=Former; Age=62.3 SUBJECT_SAMPLE_FACTORS - C089 SampleType:RCC RAW_FILE_NAME=C089; Sample description=Cancer (Other); Gender=Female; Race=Black/AA; BMI=30; Smoker=Never; Age=39.7 SUBJECT_SAMPLE_FACTORS - C091 SampleType:RCC RAW_FILE_NAME=C091; Sample description=Papillary RCC; Gender=Female; Race=White; BMI=31.6; Smoker=Current; Age=61.6 SUBJECT_SAMPLE_FACTORS - C092 SampleType:RCC RAW_FILE_NAME=C092; Sample description=Papillary RCC; Gender=Male; Race=White; BMI=31; Smoker=Never; Age=38.2 SUBJECT_SAMPLE_FACTORS - C093 SampleType:RCC RAW_FILE_NAME=C093; Sample description=Papillary RCC; Gender=Female; Race=White; BMI=34.6; Smoker=Never; Age=53.7 SUBJECT_SAMPLE_FACTORS - C095 SampleType:RCC RAW_FILE_NAME=C095; Sample description=Papillary RCC; Gender=Male; Race=Black/AA; BMI=21.7; Smoker=Never; Age=72.4 SUBJECT_SAMPLE_FACTORS - C096 SampleType:RCC RAW_FILE_NAME=C096; Sample description=Clear Cell Papillary; Gender=Male; Race=Black/AA; BMI=21.7; Smoker=Never; Age=66.3 SUBJECT_SAMPLE_FACTORS - C097 SampleType:RCC RAW_FILE_NAME=C097; Sample description=Clear Cell Papillary; Gender=Female; Race=Black/AA; BMI=30.5; Smoker=Never; Age=64.3 SUBJECT_SAMPLE_FACTORS - C099 SampleType:RCC RAW_FILE_NAME=C099; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=Black/AA; BMI=36.8; Smoker=Former; Age=58 SUBJECT_SAMPLE_FACTORS - C101 SampleType:RCC RAW_FILE_NAME=C101; Sample description=Cancer (Other); Gender=Female; Race=Black/AA; BMI=28.5; Smoker=Never; Age=32.6 SUBJECT_SAMPLE_FACTORS - C102 SampleType:RCC RAW_FILE_NAME=C102; Sample description=Papillary RCC; Gender=Female; Race=White; BMI=26.3; Smoker=Current; Age=60.2 SUBJECT_SAMPLE_FACTORS - N001 SampleType:Control RAW_FILE_NAME=N001; Sample description=Control; Gender=Male; Race=White; BMI=28.6; Smoker=Never; Age=52 SUBJECT_SAMPLE_FACTORS - N002 SampleType:Control RAW_FILE_NAME=N002; Sample description=Control; Gender=Female; Race=White; BMI=28.6; Smoker=Former; Age=70 SUBJECT_SAMPLE_FACTORS - N003 SampleType:Control RAW_FILE_NAME=N003; Sample description=Control; Gender=Male; Race=White; BMI=25.7; Smoker=Former; Age=54 SUBJECT_SAMPLE_FACTORS - N004 SampleType:Control RAW_FILE_NAME=N004; Sample description=Control; Gender=Male; Race=White; BMI=25.9; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N005 SampleType:Control RAW_FILE_NAME=N005; Sample description=Control; Gender=Male; Race=White; BMI=30.1; Smoker=Never; Age=63 SUBJECT_SAMPLE_FACTORS - N006 SampleType:Control RAW_FILE_NAME=N006; Sample description=Control; Gender=Male; Race=White; BMI=29.5; Smoker=Never; Age=47 SUBJECT_SAMPLE_FACTORS - N007 SampleType:Control RAW_FILE_NAME=N007; Sample description=Control; Gender=Male; Race=Black/AA; BMI=32.2; Smoker=Former; Age=41 SUBJECT_SAMPLE_FACTORS - N008 SampleType:Control RAW_FILE_NAME=N008; Sample description=Control; Gender=Male; Race=White; BMI=25; Smoker=Never; Age=46 SUBJECT_SAMPLE_FACTORS - N009 SampleType:Control RAW_FILE_NAME=N009; Sample description=Control; Gender=Female; Race=White; BMI=25.2; Smoker=Former; Age=71 SUBJECT_SAMPLE_FACTORS - N010 SampleType:Control RAW_FILE_NAME=N010; Sample description=Control; Gender=Male; Race=White; BMI=29.5; Smoker=Never; Age=60 SUBJECT_SAMPLE_FACTORS - N011 SampleType:Control RAW_FILE_NAME=N011; Sample description=Control; Gender=Male; Race=White; BMI=30.9; Smoker=Never; Age=52 SUBJECT_SAMPLE_FACTORS - N012 SampleType:Control RAW_FILE_NAME=N012; Sample description=Control; Gender=Female; Race=White; BMI=21.3; Smoker=Never; Age=56 SUBJECT_SAMPLE_FACTORS - N013 SampleType:Control RAW_FILE_NAME=N013; Sample description=Control; Gender=Male; Race=White; BMI=22.7; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N014 SampleType:Control RAW_FILE_NAME=N014; Sample description=Control; Gender=Male; Race=White; BMI=27; Smoker=Never; Age=56 SUBJECT_SAMPLE_FACTORS - N015 SampleType:Control RAW_FILE_NAME=N015; Sample description=Control; Gender=Male; Race=White; BMI=38.2; Smoker=Never; Age=53 SUBJECT_SAMPLE_FACTORS - N016 SampleType:Control RAW_FILE_NAME=N016; Sample description=Control; Gender=Male; Race=White; BMI=33.1; Smoker=Never; Age=46 SUBJECT_SAMPLE_FACTORS - N017 SampleType:Control RAW_FILE_NAME=N017; Sample description=Control; Gender=Male; Race=White; BMI=33.7; Smoker=Former; Age=52 SUBJECT_SAMPLE_FACTORS - N018 SampleType:Control RAW_FILE_NAME=N018; Sample description=Control; Gender=Female; Race=White; BMI=27.7; Smoker=Never; Age=45 SUBJECT_SAMPLE_FACTORS - N019 SampleType:Control RAW_FILE_NAME=N019; Sample description=Control; Gender=Male; Race=White; BMI=24.6; Smoker=Never; Age=52 SUBJECT_SAMPLE_FACTORS - N020 SampleType:Control RAW_FILE_NAME=N020; Sample description=Control; Gender=Male; Race=White; BMI=23.6; Smoker=Former; Age=64 SUBJECT_SAMPLE_FACTORS - N021 SampleType:Control RAW_FILE_NAME=N021; Sample description=Control; Gender=Male; Race=White; BMI=27.3; Smoker=Never; Age=51 SUBJECT_SAMPLE_FACTORS - N022 SampleType:Control RAW_FILE_NAME=N022; Sample description=Control; Gender=Male; Race=White; BMI=30.1; Smoker=Current; Age=63 SUBJECT_SAMPLE_FACTORS - N023 SampleType:Control RAW_FILE_NAME=N023; Sample description=Control; Gender=Male; Race=White; BMI=23.7; Smoker=Former; Age=49 SUBJECT_SAMPLE_FACTORS - N024 SampleType:Control RAW_FILE_NAME=N024; Sample description=Control; Gender=Male; Race=White; BMI=26.9; Smoker=Never; Age=48 SUBJECT_SAMPLE_FACTORS - N025 SampleType:Control RAW_FILE_NAME=N025; Sample description=Control; Gender=Male; Race=White; BMI=36.2; Smoker=Current; Age=57 SUBJECT_SAMPLE_FACTORS - N026 SampleType:Control RAW_FILE_NAME=N026; Sample description=Control; Gender=Male; Race=Asian; BMI=22.2; Smoker=Never; Age=48 SUBJECT_SAMPLE_FACTORS - N027 SampleType:Control RAW_FILE_NAME=N027; Sample description=Control; Gender=Male; Race=White; BMI=24.7; Smoker=Never; Age=66 SUBJECT_SAMPLE_FACTORS - N028 SampleType:Control RAW_FILE_NAME=N028; Sample description=Control; Gender=Male; Race=Unk/Missing; BMI=29.3; Smoker=Former; Age=48 SUBJECT_SAMPLE_FACTORS - N029 SampleType:Control RAW_FILE_NAME=N029; Sample description=Control; Gender=Female; Race=White; BMI=31.7; Smoker=Never; Age=41 SUBJECT_SAMPLE_FACTORS - N030 SampleType:Control RAW_FILE_NAME=N030; Sample description=Control; Gender=Male; Race=White; BMI=29; Smoker=Never; Age=59 SUBJECT_SAMPLE_FACTORS - N031 SampleType:Control RAW_FILE_NAME=N031; Sample description=Control; Gender=Male; Race=White; BMI=24.5; Smoker=Former; Age=71 SUBJECT_SAMPLE_FACTORS - N032 SampleType:Control RAW_FILE_NAME=N032; Sample description=Control; Gender=Female; Race=White; BMI=32.8; Smoker=Former; Age=70 SUBJECT_SAMPLE_FACTORS - N033 SampleType:Control RAW_FILE_NAME=N033; Sample description=Control; Gender=Male; Race=White; BMI=24.1; Smoker=Never; Age=43 SUBJECT_SAMPLE_FACTORS - N034 SampleType:Control RAW_FILE_NAME=N034; Sample description=Control; Gender=Male; Race=White; BMI=28.3; Smoker=Never; Age=63 SUBJECT_SAMPLE_FACTORS - N035 SampleType:Control RAW_FILE_NAME=N035; Sample description=Control; Gender=Male; Race=White; BMI=27.9; Smoker=Former; Age=57 SUBJECT_SAMPLE_FACTORS - N036 SampleType:Control RAW_FILE_NAME=N036; Sample description=Control; Gender=Male; Race=White; BMI=25.9; Smoker=Never; Age=55 SUBJECT_SAMPLE_FACTORS - N037 SampleType:Control RAW_FILE_NAME=N037; Sample description=Control; Gender=Male; Race=White; BMI=24.2; Smoker=Former; Age=83 SUBJECT_SAMPLE_FACTORS - N038 SampleType:Control RAW_FILE_NAME=N038; Sample description=Control; Gender=Male; Race=White; BMI=28.7; Smoker=Never; Age=64 SUBJECT_SAMPLE_FACTORS - N039 SampleType:Control RAW_FILE_NAME=N039; Sample description=Control; Gender=Male; Race=White; BMI=25.5; Smoker=Never; Age=74 SUBJECT_SAMPLE_FACTORS - N040 SampleType:Control RAW_FILE_NAME=N040; Sample description=Control; Gender=Male; Race=White; BMI=26.6; Smoker=Never; Age=57 SUBJECT_SAMPLE_FACTORS - N041 SampleType:Control RAW_FILE_NAME=N041; Sample description=Control; Gender=Male; Race=White; BMI=20.4; Smoker=Current; Age=57 SUBJECT_SAMPLE_FACTORS - N042 SampleType:Control RAW_FILE_NAME=N042; Sample description=Control; Gender=Male; Race=White; BMI=33.6; Smoker=Never; Age=42 SUBJECT_SAMPLE_FACTORS - N043 SampleType:Control RAW_FILE_NAME=N043; Sample description=Control; Gender=Male; Race=White; BMI=27; Smoker=Never; Age=41 SUBJECT_SAMPLE_FACTORS - N044 SampleType:Control RAW_FILE_NAME=N044; Sample description=Control; Gender=Male; Race=White; BMI=32.1; Smoker=Former; Age=44 SUBJECT_SAMPLE_FACTORS - N045 SampleType:Control RAW_FILE_NAME=N045; Sample description=Control; Gender=Male; Race=White; BMI=20.7; Smoker=Former; Age=43 SUBJECT_SAMPLE_FACTORS - N046 SampleType:Control RAW_FILE_NAME=N046; Sample description=Control; Gender=Male; Race=White; BMI=20.9; Smoker=Never; Age=48 SUBJECT_SAMPLE_FACTORS - N047 SampleType:Control RAW_FILE_NAME=N047; Sample description=Control; Gender=Female; Race=White; BMI=25.3; Smoker=Never; Age=43 SUBJECT_SAMPLE_FACTORS - N048 SampleType:Control RAW_FILE_NAME=N048; Sample description=Control; Gender=Male; Race=White; BMI=35.4; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N049 SampleType:Control RAW_FILE_NAME=N049; Sample description=Control; Gender=Male; Race=White; BMI=26.1; Smoker=Never; Age=43 SUBJECT_SAMPLE_FACTORS - N050 SampleType:Control RAW_FILE_NAME=N050; Sample description=Control; Gender=Male; Race=White; BMI=22.2; Smoker=Never; Age=65 SUBJECT_SAMPLE_FACTORS - N051 SampleType:Control RAW_FILE_NAME=N051; Sample description=Control; Gender=Male; Race=White; BMI=23.2; Smoker=Never; Age=42 SUBJECT_SAMPLE_FACTORS - N052 SampleType:Control RAW_FILE_NAME=N052; Sample description=Control; Gender=Male; Race=White; BMI=29.1; Smoker=Former; Age=57 SUBJECT_SAMPLE_FACTORS - N053 SampleType:Control RAW_FILE_NAME=N053; Sample description=Control; Gender=Male; Race=White; BMI=32; Smoker=Never; Age=49 SUBJECT_SAMPLE_FACTORS - N054 SampleType:Control RAW_FILE_NAME=N054; Sample description=Control; Gender=Male; Race=White; BMI=23.8; Smoker=Never; Age=41 SUBJECT_SAMPLE_FACTORS - N055 SampleType:Control RAW_FILE_NAME=N055; Sample description=Control; Gender=Male; Race=White; BMI=40.4; Smoker=Former; Age=49 SUBJECT_SAMPLE_FACTORS - N056 SampleType:Control RAW_FILE_NAME=N056; Sample description=Control; Gender=Male; Race=White; BMI=31.1; Smoker=Never; Age=48 SUBJECT_SAMPLE_FACTORS - N057 SampleType:Control RAW_FILE_NAME=N057; Sample description=Control; Gender=Male; Race=White; BMI=23.9; Smoker=Never; Age=47 SUBJECT_SAMPLE_FACTORS - N058 SampleType:Control RAW_FILE_NAME=N058; Sample description=Control; Gender=Male; Race=White; BMI=26; Smoker=Never; Age=45 SUBJECT_SAMPLE_FACTORS - N059 SampleType:Control RAW_FILE_NAME=N059; Sample description=Control; Gender=Male; Race=Unk/Missing; BMI=27.8; Smoker=Never; Age=64 SUBJECT_SAMPLE_FACTORS - N060 SampleType:Control RAW_FILE_NAME=N060; Sample description=Control; Gender=Male; Race=White; BMI=29.6; Smoker=Never; Age=55 SUBJECT_SAMPLE_FACTORS - N062 SampleType:Control RAW_FILE_NAME=N062; Sample description=Control; Gender=Female; Race=White; BMI=19.2; Smoker=Never; Age=55 SUBJECT_SAMPLE_FACTORS - N063 SampleType:Control RAW_FILE_NAME=N063; Sample description=Control; Gender=Male; Race=White; BMI=30.9; Smoker=Never; Age=65 SUBJECT_SAMPLE_FACTORS - N064 SampleType:Control RAW_FILE_NAME=N064; Sample description=Control; Gender=Male; Race=White; BMI=26; Smoker=Former; Age=54 SUBJECT_SAMPLE_FACTORS - N065 SampleType:Control RAW_FILE_NAME=N065; Sample description=Control; Gender=Male; Race=White; BMI=29.9; Smoker=Never; Age=60 SUBJECT_SAMPLE_FACTORS - N066 SampleType:Control RAW_FILE_NAME=N066; Sample description=Control; Gender=Male; Race=White; BMI=27.2; Smoker=Never; Age=46 SUBJECT_SAMPLE_FACTORS - N067 SampleType:Control RAW_FILE_NAME=N067; Sample description=Control; Gender=Male; Race=White; BMI=25; Smoker=Former; Age=79 SUBJECT_SAMPLE_FACTORS - N068 SampleType:Control RAW_FILE_NAME=N068; Sample description=Control; Gender=Male; Race=Black/AA; BMI=33; Smoker=Never; Age=57 SUBJECT_SAMPLE_FACTORS - N069 SampleType:Control RAW_FILE_NAME=N069; Sample description=Control; Gender=Male; Race=White; BMI=36.9; Smoker=Former; Age=58 SUBJECT_SAMPLE_FACTORS - N070 SampleType:Control RAW_FILE_NAME=N070; Sample description=Control; Gender=Male; Race=White; BMI=30.3; Smoker=Never; Age=64 SUBJECT_SAMPLE_FACTORS - N071 SampleType:Control RAW_FILE_NAME=N071; Sample description=Control; Gender=Male; Race=White; BMI=23.1; Smoker=Never; Age=63 SUBJECT_SAMPLE_FACTORS - N072 SampleType:Control RAW_FILE_NAME=N072; Sample description=Control; Gender=Male; Race=White; BMI=28.7; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N073 SampleType:Control RAW_FILE_NAME=N073; Sample description=Control; Gender=Male; Race=White; BMI=24.6; Smoker=Never; Age=64 SUBJECT_SAMPLE_FACTORS - N074 SampleType:Control RAW_FILE_NAME=N074; Sample description=Control; Gender=Male; Race=White; BMI=25.4; Smoker=Never; Age=64 SUBJECT_SAMPLE_FACTORS - N075 SampleType:Control RAW_FILE_NAME=N075; Sample description=Control; Gender=Female; Race=White; BMI=23.9; Smoker=Former; Age=66 SUBJECT_SAMPLE_FACTORS - N076 SampleType:Control RAW_FILE_NAME=N076; Sample description=Control; Gender=Male; Race=White; BMI=24.7; Smoker=Former; Age=72 SUBJECT_SAMPLE_FACTORS - N077 SampleType:Control RAW_FILE_NAME=N077; Sample description=Control; Gender=Female; Race=White; BMI=22.9; Smoker=Never; Age=54 SUBJECT_SAMPLE_FACTORS - N078 SampleType:Control RAW_FILE_NAME=N078; Sample description=Control; Gender=Male; Race=White; BMI=25; Smoker=Never; Age=45 SUBJECT_SAMPLE_FACTORS - N079 SampleType:Control RAW_FILE_NAME=N079; Sample description=Control; Gender=Male; Race=White; BMI=27.6; Smoker=Never; Age=51 SUBJECT_SAMPLE_FACTORS - N080 SampleType:Control RAW_FILE_NAME=N080; Sample description=Control; Gender=Male; Race=White; BMI=29.1; Smoker=Former; Age=47 SUBJECT_SAMPLE_FACTORS - N081 SampleType:Control RAW_FILE_NAME=N081; Sample description=Control; Gender=Female; Race=White; BMI=20; Smoker=Never; Age=63 SUBJECT_SAMPLE_FACTORS - N082 SampleType:Control RAW_FILE_NAME=N082; Sample description=Control; Gender=Male; Race=White; BMI=25.9; Smoker=Never; Age=82 SUBJECT_SAMPLE_FACTORS - N083 SampleType:Control RAW_FILE_NAME=N083; Sample description=Control; Gender=Female; Race=White; BMI=23.1; Smoker=Never; Age=38 SUBJECT_SAMPLE_FACTORS - N084 SampleType:Control RAW_FILE_NAME=N084; Sample description=Control; Gender=Male; Race=White; BMI=28; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N085 SampleType:Control RAW_FILE_NAME=N085; Sample description=Control; Gender=Male; Race=White; BMI=30.7; Smoker=Never; Age=43 SUBJECT_SAMPLE_FACTORS - N086 SampleType:Control RAW_FILE_NAME=N086; Sample description=Control; Gender=Male; Race=White; BMI=23.3; Smoker=Never; Age=40 SUBJECT_SAMPLE_FACTORS - N087 SampleType:Control RAW_FILE_NAME=N087; Sample description=Control; Gender=Male; Race=White; BMI=21.2; Smoker=Never; Age=52 SUBJECT_SAMPLE_FACTORS - N088 SampleType:Control RAW_FILE_NAME=N088; Sample description=Control; Gender=Male; Race=White; BMI=27; Smoker=Former; Age=66 SUBJECT_SAMPLE_FACTORS - N089 SampleType:Control RAW_FILE_NAME=N089; Sample description=Control; Gender=Male; Race=White; BMI=28.1; Smoker=Former; Age=65 SUBJECT_SAMPLE_FACTORS - N090 SampleType:Control RAW_FILE_NAME=N090; Sample description=Control; Gender=Male; Race=White; BMI=26.8; Smoker=Never; Age=60 SUBJECT_SAMPLE_FACTORS - N091 SampleType:Control RAW_FILE_NAME=N091; Sample description=Control; Gender=Male; Race=White; BMI=34.2; Smoker=Never; Age=40 SUBJECT_SAMPLE_FACTORS - N092 SampleType:Control RAW_FILE_NAME=N092; Sample description=Control; Gender=Male; Race=White; BMI=30.8; Smoker=Never; Age=56 SUBJECT_SAMPLE_FACTORS - N093 SampleType:Control RAW_FILE_NAME=N093; Sample description=Control; Gender=Male; Race=White; BMI=27.5; Smoker=Never; Age=48 SUBJECT_SAMPLE_FACTORS - N094 SampleType:Control RAW_FILE_NAME=N094; Sample description=Control; Gender=Male; Race=White; BMI=28.4; Smoker=Never; Age=85 SUBJECT_SAMPLE_FACTORS - N095 SampleType:Control RAW_FILE_NAME=N095; Sample description=Control; Gender=Male; Race=White; BMI=25.5; Smoker=Never; Age=22 SUBJECT_SAMPLE_FACTORS - N096 SampleType:Control RAW_FILE_NAME=N096; Sample description=Control; Gender=Male; Race=White; BMI=30.6; Smoker=Former; Age=49 SUBJECT_SAMPLE_FACTORS - N097 SampleType:Control RAW_FILE_NAME=N097; Sample description=Control; Gender=Male; Race=White; BMI=25.5; Smoker=Former; Age=60 SUBJECT_SAMPLE_FACTORS - N098 SampleType:Control RAW_FILE_NAME=N098; Sample description=Control; Gender=Male; Race=White; BMI=24.7; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N099 SampleType:Control RAW_FILE_NAME=N099; Sample description=Control; Gender=Male; Race=White; BMI=28; Smoker=Never; Age=51 SUBJECT_SAMPLE_FACTORS - N100 SampleType:Control RAW_FILE_NAME=N100; Sample description=Control; Gender=Male; Race=White; BMI=30.6; Smoker=Never; Age=54 SUBJECT_SAMPLE_FACTORS - N101 SampleType:Control RAW_FILE_NAME=N101; Sample description=Control; Gender=Male; Race=White; BMI=33.2; Smoker=Never; Age=42 SUBJECT_SAMPLE_FACTORS - N102 SampleType:Control RAW_FILE_NAME=N102; Sample description=Control; Gender=Male; Race=Black/AA; BMI=29.5; Smoker=Never; Age=53 SUBJECT_SAMPLE_FACTORS - N103 SampleType:Control RAW_FILE_NAME=N103; Sample description=Control; Gender=Male; Race=White; BMI=30.6; Smoker=Former; Age=55 SUBJECT_SAMPLE_FACTORS - N105 SampleType:Control RAW_FILE_NAME=N105; Sample description=Control; Gender=Male; Race=White; BMI=28.8; Smoker=Never; Age=48 SUBJECT_SAMPLE_FACTORS - N106 SampleType:Control RAW_FILE_NAME=N106; Sample description=Control; Gender=Male; Race=White; BMI=25.9; Smoker=Former; Age=68 SUBJECT_SAMPLE_FACTORS - N107 SampleType:Control RAW_FILE_NAME=N107; Sample description=Control; Gender=Male; Race=White; BMI=27.9; Smoker=Former; Age=55 SUBJECT_SAMPLE_FACTORS - N108 SampleType:Control RAW_FILE_NAME=N108; Sample description=Control; Gender=Male; Race=White; BMI=30.7; Smoker=Never; Age=58 SUBJECT_SAMPLE_FACTORS - N109 SampleType:Control RAW_FILE_NAME=N109; Sample description=Control; Gender=Male; Race=White; BMI=25; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N110 SampleType:Control RAW_FILE_NAME=N110; Sample description=Control; Gender=Female; Race=White; BMI=23.8; Smoker=Never; Age=46 SUBJECT_SAMPLE_FACTORS - N111 SampleType:Control RAW_FILE_NAME=N111; Sample description=Control; Gender=Male; Race=White; BMI=27.3; Smoker=Never; Age=56 SUBJECT_SAMPLE_FACTORS - N112 SampleType:Control RAW_FILE_NAME=N112; Sample description=Control; Gender=Male; Race=White; BMI=25.4; Smoker=Never; Age=62 SUBJECT_SAMPLE_FACTORS - N113 SampleType:Control RAW_FILE_NAME=N113; Sample description=Control; Gender=Male; Race=White; BMI=24.3; Smoker=Former; Age=83 SUBJECT_SAMPLE_FACTORS - N114 SampleType:Control RAW_FILE_NAME=N114; Sample description=Control; Gender=Female; Race=Unk/Missing; BMI=23.2; Smoker=Current; Age=39 SUBJECT_SAMPLE_FACTORS - N115 SampleType:Control RAW_FILE_NAME=N115; Sample description=Control; Gender=Male; Race=White; BMI=37.1; Smoker=Former; Age=38 SUBJECT_SAMPLE_FACTORS - N116 SampleType:Control RAW_FILE_NAME=N116; Sample description=Control; Gender=Female; Race=Black/AA; BMI=23; Smoker=Never; Age=53 SUBJECT_SAMPLE_FACTORS - N117 SampleType:Control RAW_FILE_NAME=N117; Sample description=Control; Gender=Female; Race=White; BMI=26.8; Smoker=Never; Age=56 SUBJECT_SAMPLE_FACTORS - N118 SampleType:Control RAW_FILE_NAME=N118; Sample description=Control; Gender=Female; Race=White; BMI=18.9; Smoker=Former; Age=75 SUBJECT_SAMPLE_FACTORS - N119 SampleType:Control RAW_FILE_NAME=N119; Sample description=Control; Gender=Female; Race=White; BMI=21.1; Smoker=Never; Age=53 SUBJECT_SAMPLE_FACTORS - N120 SampleType:Control RAW_FILE_NAME=N120; Sample description=Control; Gender=Male; Race=White; BMI=39.5; Smoker=Never; Age=60 SUBJECT_SAMPLE_FACTORS - N121 SampleType:Control RAW_FILE_NAME=N121; Sample description=Control; Gender=Male; Race=White; BMI=20.5; Smoker=Never; Age=45 SUBJECT_SAMPLE_FACTORS - N122 SampleType:Control RAW_FILE_NAME=N122; Sample description=Control; Gender=Male; Race=White; BMI=29; Smoker=Never; Age=56 SUBJECT_SAMPLE_FACTORS - N123 SampleType:Control RAW_FILE_NAME=N123; Sample description=Control; Gender=Male; Race=White; BMI=26.6; Smoker=Former; Age=59 SUBJECT_SAMPLE_FACTORS - N124 SampleType:Control RAW_FILE_NAME=N124; Sample description=Control; Gender=Male; Race=White; BMI=20.1; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N125 SampleType:Control RAW_FILE_NAME=N125; Sample description=Control; Gender=Female; Race=White; BMI=33; Smoker=Never; Age=66 SUBJECT_SAMPLE_FACTORS - N126 SampleType:Control RAW_FILE_NAME=N126; Sample description=Control; Gender=Male; Race=Black/AA; BMI=29.4; Smoker=Former; Age=56 SUBJECT_SAMPLE_FACTORS - N127 SampleType:Control RAW_FILE_NAME=N127; Sample description=Control; Gender=Male; Race=White; BMI=32.1; Smoker=Never; Age=54 SUBJECT_SAMPLE_FACTORS - N128 SampleType:Control RAW_FILE_NAME=N128; Sample description=Control; Gender=Female; Race=White; BMI=34.7; Smoker=Never; Age=56 SUBJECT_SAMPLE_FACTORS - N129 SampleType:Control RAW_FILE_NAME=N129; Sample description=Control; Gender=Male; Race=White; BMI=22.4; Smoker=Former; Age=46 SUBJECT_SAMPLE_FACTORS - N130 SampleType:Control RAW_FILE_NAME=N130; Sample description=Control; Gender=Male; Race=White; BMI=29.3; Smoker=Never; Age=59 SUBJECT_SAMPLE_FACTORS - N131 SampleType:Control RAW_FILE_NAME=N131; Sample description=Control; Gender=Female; Race=White; BMI=21.9; Smoker=Current; Age=59 SUBJECT_SAMPLE_FACTORS - N132 SampleType:Control RAW_FILE_NAME=N132; Sample description=Control; Gender=Female; Race=White; BMI=19.8; Smoker=Never; Age=54 SUBJECT_SAMPLE_FACTORS - N133 SampleType:Control RAW_FILE_NAME=N133; Sample description=Control; Gender=Male; Race=White; BMI=30.3; Smoker=Never; Age=46 SUBJECT_SAMPLE_FACTORS - N134 SampleType:Control RAW_FILE_NAME=N134; Sample description=Control; Gender=Male; Race=White; BMI=32.7; Smoker=Never; Age=59 SUBJECT_SAMPLE_FACTORS - N135 SampleType:Control RAW_FILE_NAME=N135; Sample description=Control; Gender=Female; Race=White; BMI=25.9; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N136 SampleType:Control RAW_FILE_NAME=N136; Sample description=Control; Gender=Male; Race=White; BMI=46.6; Smoker=Never; Age=60 SUBJECT_SAMPLE_FACTORS - N137 SampleType:Control RAW_FILE_NAME=N137; Sample description=Control; Gender=Female; Race=White; BMI=23.4; Smoker=Never; Age=55 SUBJECT_SAMPLE_FACTORS - N138 SampleType:Control RAW_FILE_NAME=N138; Sample description=Control; Gender=Male; Race=White; BMI=34.5; Smoker=Former; Age=44 SUBJECT_SAMPLE_FACTORS - N139 SampleType:Control RAW_FILE_NAME=N139; Sample description=Control; Gender=Male; Race=White; BMI=25.2; Smoker=Never; Age=57 SUBJECT_SAMPLE_FACTORS - N140 SampleType:Control RAW_FILE_NAME=N140; Sample description=Control; Gender=Male; Race=White; BMI=28.5; Smoker=Never; Age=53 SUBJECT_SAMPLE_FACTORS - N141 SampleType:Control RAW_FILE_NAME=N141; Sample description=Control; Gender=Male; Race=White; BMI=31.2; Smoker=Former; Age=68 SUBJECT_SAMPLE_FACTORS - N142 SampleType:Control RAW_FILE_NAME=N142; Sample description=Control; Gender=Male; Race=White; BMI=30; Smoker=Never; Age=77 SUBJECT_SAMPLE_FACTORS - N143 SampleType:Control RAW_FILE_NAME=N143; Sample description=Control; Gender=Female; Race=White; BMI=17.5; Smoker=Never; Age=77 SUBJECT_SAMPLE_FACTORS - N144 SampleType:Control RAW_FILE_NAME=N144; Sample description=Control; Gender=Male; Race=White; BMI=28.4; Smoker=Never; Age=57 SUBJECT_SAMPLE_FACTORS - N145 SampleType:Control RAW_FILE_NAME=N145; Sample description=Control; Gender=Male; Race=White; BMI=27.1; Smoker=Never; Age=53 SUBJECT_SAMPLE_FACTORS - N146 SampleType:Control RAW_FILE_NAME=N146; Sample description=Control; Gender=Male; Race=White; BMI=29.1; Smoker=Never; Age=58 SUBJECT_SAMPLE_FACTORS - N147 SampleType:Control RAW_FILE_NAME=N147; Sample description=Control; Gender=Male; Race=White; BMI=26.9; Smoker=Never; Age=60 SUBJECT_SAMPLE_FACTORS - N148 SampleType:Control RAW_FILE_NAME=N148; Sample description=Control; Gender=Female; Race=White; BMI=26.1; Smoker=Never; Age=57 SUBJECT_SAMPLE_FACTORS - N150 SampleType:Control RAW_FILE_NAME=N150; Sample description=Control; Gender=Male; Race=White; BMI=23.3; Smoker=Never; Age=57 SUBJECT_SAMPLE_FACTORS - N151 SampleType:Control RAW_FILE_NAME=N151; Sample description=Control; Gender=Male; Race=White; BMI=22.2; Smoker=Never; Age=49 SUBJECT_SAMPLE_FACTORS - N152 SampleType:Control RAW_FILE_NAME=N152; Sample description=Control; Gender=Male; Race=White; BMI=23.4; Smoker=Never; Age=40 SUBJECT_SAMPLE_FACTORS - N153 SampleType:Control RAW_FILE_NAME=N153; Sample description=Control; Gender=Male; Race=White; BMI=31.4; Smoker=Never; Age=58 SUBJECT_SAMPLE_FACTORS - N154 SampleType:Control RAW_FILE_NAME=N154; Sample description=Control; Gender=Male; Race=White; BMI=24.9; Smoker=Never; Age=44 SUBJECT_SAMPLE_FACTORS - N155 SampleType:Control RAW_FILE_NAME=N155; Sample description=Control; Gender=Male; Race=White; BMI=25; Smoker=Never; Age=45 SUBJECT_SAMPLE_FACTORS - N156 SampleType:Control RAW_FILE_NAME=N156; Sample description=Control; Gender=Male; Race=White; BMI=24.9; Smoker=Never; Age=52 SUBJECT_SAMPLE_FACTORS - N157 SampleType:Control RAW_FILE_NAME=N157; Sample description=Control; Gender=Male; Race=White; BMI=24.8; Smoker=Never; Age=56 SUBJECT_SAMPLE_FACTORS - N158 SampleType:Control RAW_FILE_NAME=N158; Sample description=Control; Gender=Male; Race=White; BMI=34.9; Smoker=Never; Age=66 SUBJECT_SAMPLE_FACTORS - N159 SampleType:Control RAW_FILE_NAME=N159; Sample description=Control; Gender=Male; Race=White; BMI=34.3; Smoker=Never; Age=61 SUBJECT_SAMPLE_FACTORS - N160 SampleType:Control RAW_FILE_NAME=N160; Sample description=Control; Gender=Male; Race=White; BMI=26.8; Smoker=Never; Age=52 SUBJECT_SAMPLE_FACTORS - N161 SampleType:Control RAW_FILE_NAME=N161; Sample description=Control; Gender=Female; Race=White; BMI=31.4; Smoker=Former; Age=55 SUBJECT_SAMPLE_FACTORS - N162 SampleType:Control RAW_FILE_NAME=N162; Sample description=Control; Gender=Male; Race=Unk/Missing; BMI=24.8; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N163 SampleType:Control RAW_FILE_NAME=N163; Sample description=Control; Gender=Male; Race=White; BMI=31.3; Smoker=Never; Age=59 SUBJECT_SAMPLE_FACTORS - N164 SampleType:Control RAW_FILE_NAME=N164; Sample description=Control; Gender=Male; Race=White; BMI=32; Smoker=Never; Age=56 SUBJECT_SAMPLE_FACTORS - N165 SampleType:Control RAW_FILE_NAME=N165; Sample description=Control; Gender=Male; Race=White; BMI=26; Smoker=Never; Age=54 SUBJECT_SAMPLE_FACTORS - N166 SampleType:Control RAW_FILE_NAME=N166; Sample description=Control; Gender=Male; Race=White; BMI=23.6; Smoker=Never; Age=38 SUBJECT_SAMPLE_FACTORS - N167 SampleType:Control RAW_FILE_NAME=N167; Sample description=Control; Gender=Male; Race=White; BMI=24.8; Smoker=Never; Age=65 SUBJECT_SAMPLE_FACTORS - N168 SampleType:Control RAW_FILE_NAME=N168; Sample description=Control; Gender=Male; Race=Unk/Missing; BMI=21.7; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N169 SampleType:Control RAW_FILE_NAME=N169; Sample description=Control; Gender=Female; Race=White; BMI=21.2; Smoker=Never; Age=50 SUBJECT_SAMPLE_FACTORS - N170 SampleType:Control RAW_FILE_NAME=N170; Sample description=Control; Gender=Male; Race=White; BMI=22.5; Smoker=Never; Age=39 SUBJECT_SAMPLE_FACTORS - N171 SampleType:Control RAW_FILE_NAME=N171; Sample description=Control; Gender=Male; Race=White; BMI=20.4; Smoker=Never; Age=36 SUBJECT_SAMPLE_FACTORS - N172 SampleType:Control RAW_FILE_NAME=N172; Sample description=Control; Gender=Male; Race=White; BMI=26.2; Smoker=Never; Age=60 SUBJECT_SAMPLE_FACTORS - N174 SampleType:Control RAW_FILE_NAME=N174; Sample description=Control; Gender=Male; Race=White; BMI=28; Smoker=Never; Age=62 SUBJECT_SAMPLE_FACTORS - N175 SampleType:Control RAW_FILE_NAME=N175; Sample description=Control; Gender=Male; Race=White; BMI=28.6; Smoker=Never; Age=42 SUBJECT_SAMPLE_FACTORS - N176 SampleType:Control RAW_FILE_NAME=N176; Sample description=Control; Gender=Female; Race=Unk/Missing; BMI=23.4; Smoker=Never; Age=26 SUBJECT_SAMPLE_FACTORS - N177 SampleType:Control RAW_FILE_NAME=N177; Sample description=Control; Gender=Male; Race=White; BMI=24.9; Smoker=Never; Age=55 SUBJECT_SAMPLE_FACTORS - N178 SampleType:Control RAW_FILE_NAME=N178; Sample description=Control; Gender=Male; Race=White; BMI=26.9; Smoker=Never; Age=48 #COLLECTION CO:COLLECTION_SUMMARY Urine samples were collected at the Emory University Hospital CO:COLLECTION_PROTOCOL_FILENAME 2_Collection_protocol_RCC_FEB2021.docx CO:SAMPLE_TYPE Urine #TREATMENT TR:TREATMENT_SUMMARY There were no treatment in the study, urine samples of healthy subjects and TR:TREATMENT_SUMMARY renal cell carcinoma patients were collected. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Urine’s samples were prepared for both NMR and MS experiments SP:SAMPLEPREP_PROTOCOL_FILENAME 3_Sample preparation protocol_RCC_FEB2021.docx SP:PROCESSING_STORAGE_CONDITIONS -80℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Q Exactive HF CH:COLUMN_NAME Waters Acquity UPLC BEH HILIC (2.1 x 75 mm, 1.7 µm) #ANALYSIS AN:ANALYSIS_TYPE MS AN:LABORATORY_NAME Fernandez Lab (Georgia Tech) #MS MS:INSTRUMENT_NAME Thermo Q Exactive HF hybrid Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS -- MS:MS_RESULTS_FILE ST001705_AN002778_Results.txt UNITS:A.U. Has m/z:No Has RT:Yes RT units:Minutes #END