#METABOLOMICS WORKBENCH Andre_Gollowitzer_20210401_063729 DATATRACK_ID:2552 STUDY_ID:ST001740 ANALYSIS_ID:AN002833 VERSION 1 CREATED_ON 06-03-2022 #PROJECT PR:PROJECT_TITLE Regulation of stress signalling by SCD1-derived phosphatidylinositols PR:PROJECT_TYPE Targeted lipidomics PR:PROJECT_SUMMARY Cytotoxic stress activates stress-activated kinases, initiates adaptive PR:PROJECT_SUMMARY mechanisms, including the unfolded protein response (UPR) and autophagy, and PR:PROJECT_SUMMARY induces programmed cell death. Fatty acid unsaturation, controlled by PR:PROJECT_SUMMARY stearoyl-CoA desaturase (SCD)1, prevents cytotoxic stress but the mechanisms are PR:PROJECT_SUMMARY diffuse. We found that 1,2-dioleoyl-sn-glycero-3-phospho-(1’-myo-inositol) PR:PROJECT_SUMMARY [PI(18:1/18:1)] is a SCD1-derived signaling lipid, which inhibits p38 PR:PROJECT_SUMMARY mitogen-activated protein kinase (MAPK) activation, counteracts UPR, autophagy PR:PROJECT_SUMMARY and apoptosis induction, and maintains cell morphology and proliferation. SCD1 PR:PROJECT_SUMMARY expression and the cellular PI(18:1/18:1) proportion decrease during the onset PR:PROJECT_SUMMARY of cell death, thereby activating stress signaling. This counter-regulation PR:PROJECT_SUMMARY applies to mechanistically diverse death-inducing conditions and occurs in PR:PROJECT_SUMMARY tissues of Scd1-defective mice. PR:INSTITUTE University of Innsbruck PR:DEPARTMENT Michael Popp Institute PR:LAST_NAME Koeberle PR:FIRST_NAME Andreas PR:ADDRESS Mitterweg 24, Innsbruck, Tyrol, 6020, Austria PR:EMAIL andreas.koeberle@uibk.ac.at PR:PHONE +43 512 507 57903 PR:FUNDING_SOURCE German Research Council (GRK 1715 and KO 4589/4-1), Phospholipid Research Center PR:FUNDING_SOURCE Heidelberg (AKO-2019-070/2-1 and AKO-2015-037/1-1), University of Jena PR:FUNDING_SOURCE (DRM/2013-05 and 2.7-05), Free State of Thuringia (41-5507-2016) and Leibniz PR:FUNDING_SOURCE ScienceCampus InfectoOptics (SAS-2015-HKI-LWC). PR:PUBLICATIONS PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling. Thürmer PR:PUBLICATIONS M, Gollowitzer A, Pein H, Neukirch K, Gelmez E, Waltl L, Wielsch N, Winkler R, PR:PUBLICATIONS Löser K, Grander J, Hotze M, Harder S, Döding A, Meßner M, Troisi F, Ardelt PR:PUBLICATIONS M, Schlüter H, Pachmayr J, Gutiérrez-Gutiérrez Ó, Rudolph KL, Thedieck K, PR:PUBLICATIONS Schulze-Späte U, González-Estévez C, Kosan C, Svatoš A, Kwiatkowski M, PR:PUBLICATIONS Koeberle A. Nat Commun. 2022 May 27;13(1):2982. doi: 10.1038/s41467-022-30374-9. PR:DOI http://dx.doi.org/10.21228/M8Q39V #STUDY ST:STUDY_TITLE Timecourse of NIH-3T3 cells treated with apoptotic inducers ST:STUDY_TYPE Targeted lipidomics ST:STUDY_SUMMARY Time-dependent changes of phosphatidylinositol profiles in mouse NIH-3T3 ST:STUDY_SUMMARY fibroblasts treated with mechanistically diverse apoptotic inducers. ST:INSTITUTE University of Innsbruck ST:DEPARTMENT Michael Popp Institute ST:LAST_NAME Koeberle ST:FIRST_NAME Andreas ST:ADDRESS Mitterweg 24, Innsbruck, Tyrol, 6020, Austria ST:EMAIL andreas.koeberle@uibk.ac.at ST:PHONE +43 512 507 57903 ST:SUBMIT_DATE 2021-04-01 #SUBJECT SU:SUBJECT_TYPE Cultured cells SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10m_1h_#45 - 5 hours:0.17 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140211_AP4_10m_1h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4und5_48h_10min_#10 - 5 hours:0.17 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140214_AP4und5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140311_AP6_10min_#45 - 5 hours:0.17 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140311_AP6_10min SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10m_1h_#46 - 6 hours:0.17 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140211_AP4_10m_1h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4und5_48h_10min_#11 - 6 hours:0.17 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140214_AP4und5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140311_AP6_10min_#46 - 6 hours:0.17 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140311_AP6_10min SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10m_1h_#50 - 10 hours:0.17 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140211_AP4_10m_1h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4und5_48h_10min_#15 - 10 hours:0.17 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140214_AP4und5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140311_AP6_10min_#50 - 10 hours:0.17 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140311_AP6_10min SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10m_1h_#49 - 9 hours:0.17 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140211_AP4_10m_1h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4und5_48h_10min_#14 - 9 hours:0.17 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140214_AP4und5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140311_AP6_10min_#49 - 9 hours:0.17 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140311_AP6_10min SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10m_1h_#44 - 4 hours:0.17 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140211_AP4_10m_1h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4und5_48h_10min_#9 - 4 hours:0.17 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140214_AP4und5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140311_AP6_10min_#44 - 4 hours:0.17 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140311_AP6_10min SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10m_1h_#43 - 3 hours:0.17 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140211_AP4_10m_1h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4und5_48h_10min_#8 - 3 hours:0.17 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140214_AP4und5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140311_AP6_10min_#43 - 3 hours:0.17 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140311_AP6_10min SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10m_1h_#47 - 7 hours:0.17 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140211_AP4_10m_1h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4und5_48h_10min_#12 - 7 hours:0.17 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140214_AP4und5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140311_AP6_10min_#47 - 7 hours:0.17 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140311_AP6_10min SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10m_1h_#48 - 8 hours:0.17 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140211_AP4_10m_1h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4und5_48h_10min_#13 - 8 hours:0.17 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140214_AP4und5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140311_AP6_10min_#48 - 8 hours:0.17 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140311_AP6_10min SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10m_1h_#42 - 2 hours:0.17 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140211_AP4_10m_1h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10m_1h_#52 - 12 hours:0.17 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140211_AP4_10m_1h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4und5_48h_10min_#17 - 12 hours:0.17 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140214_AP4und5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140214_AP4und5_48h_10min_#7 - 2 hours:0.17 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140214_AP4und5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140311_AP6_10min_#42 - 2 hours:0.17 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140311_AP6_10min SUBJECT_SAMPLE_FACTORS - HP_140311_AP6_10min_#52 - 12 hours:0.17 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140311_AP6_10min SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10min_1h_#10 - 5 hours:1 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140211_AP4_10min_1h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#45 - 5 hours:1 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140312_AP6_1h_#45 - 5 hours:1 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140312_AP6_1h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10min_1h_#11 - 6 hours:1 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140211_AP4_10min_1h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#46 - 6 hours:1 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140312_AP6_1h_#46 - 6 hours:1 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140312_AP6_1h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10min_1h_#15 - 10 hours:1 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140211_AP4_10min_1h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#50 - 10 hours:1 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140312_AP6_1h_#50 - 10 hours:1 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140312_AP6_1h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10min_1h_#14 - 9 hours:1 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140211_AP4_10min_1h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#49 - 9 hours:1 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140312_AP6_1h_#49 - 9 hours:1 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140312_AP6_1h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10min_1h_#9 - 4 hours:1 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140211_AP4_10min_1h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#44 - 4 hours:1 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140312_AP6_1h_#44 - 4 hours:1 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140312_AP6_1h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10min_1h_#8 - 3 hours:1 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140211_AP4_10min_1h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#43 - 3 hours:1 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140312_AP6_1h_#43 - 3 hours:1 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140312_AP6_1h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10min_1h_#12 - 7 hours:1 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140211_AP4_10min_1h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#47 - 7 hours:1 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140312_AP6_1h_#47 - 7 hours:1 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140312_AP6_1h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10min_1h_#13 - 8 hours:1 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140211_AP4_10min_1h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#48 - 8 hours:1 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140312_AP6_1h_#48 - 8 hours:1 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140312_AP6_1h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10min_1h_#17 - 12 hours:1 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140211_AP4_10min_1h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_10min_1h_#7 - 2 hours:1 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140211_AP4_10min_1h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#42 - 2 hours:1 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#52 - 12 hours:1 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140312_AP6_1h_#42 - 2 hours:1 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140312_AP6_1h SUBJECT_SAMPLE_FACTORS - HP_140312_AP6_1h_#52 - 12 hours:1 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140312_AP6_1h SUBJECT_SAMPLE_FACTORS - HP_140213_AP4_6h_24_restart_#30 - 5 hours:24 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140213_AP4_6h_24_restart SUBJECT_SAMPLE_FACTORS - HP_140227_AP5_24h_48h_#45 - 5 hours:24 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140227_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140314_AP6_24h_#19 - 5 hours:24 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140314_AP6_24h SUBJECT_SAMPLE_FACTORS - HP_140213_AP4_6h_24_restart_#31 - 6 hours:24 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140213_AP4_6h_24_restart SUBJECT_SAMPLE_FACTORS - HP_140227_AP5_24h_48h_#46 - 6 hours:24 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140227_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140314_AP6_24h_#20 - 6 hours:24 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140314_AP6_24h SUBJECT_SAMPLE_FACTORS - HP_140213_AP4_6h_24_restart_#35 - 10 hours:24 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140213_AP4_6h_24_restart SUBJECT_SAMPLE_FACTORS - HP_140227_AP5_24h_48h_#50 - 10 hours:24 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140227_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140314_AP6_24h_#24 - 10 hours:24 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140314_AP6_24h SUBJECT_SAMPLE_FACTORS - HP_140213_AP4_6h_24_restart_#34 - 9 hours:24 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140213_AP4_6h_24_restart SUBJECT_SAMPLE_FACTORS - HP_140227_AP5_24h_48h_#49 - 9 hours:24 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140227_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140314_AP6_24h_#23 - 9 hours:24 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140314_AP6_24h SUBJECT_SAMPLE_FACTORS - HP_140213_AP4_6h_24_restart_#29 - 4 hours:24 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140213_AP4_6h_24_restart SUBJECT_SAMPLE_FACTORS - HP_140227_AP5_24h_48h_#44 - 4 hours:24 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140227_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140314_AP6_24h_#18 - 4 hours:24 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140314_AP6_24h SUBJECT_SAMPLE_FACTORS - HP_140213_AP4_6h_24_restart_#28 - 3 hours:24 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140213_AP4_6h_24_restart SUBJECT_SAMPLE_FACTORS - HP_140227_AP5_24h_48h_#43 - 3 hours:24 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140227_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140314_AP6_24h_#17 - 3 hours:24 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140314_AP6_24h SUBJECT_SAMPLE_FACTORS - HP_140213_AP4_6h_24_restart_#32 - 7 hours:24 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140213_AP4_6h_24_restart SUBJECT_SAMPLE_FACTORS - HP_140227_AP5_24h_48h_#47 - 7 hours:24 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140227_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140314_AP6_24h_#21 - 7 hours:24 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140314_AP6_24h SUBJECT_SAMPLE_FACTORS - HP_140213_AP4_6h_24_restart_#33 - 8 hours:24 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140213_AP4_6h_24_restart SUBJECT_SAMPLE_FACTORS - HP_140227_AP5_24h_48h_#48 - 8 hours:24 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140227_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140314_AP6_24h_#22 - 8 hours:24 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140314_AP6_24h SUBJECT_SAMPLE_FACTORS - HP_140213_AP4_6h_24_restart_#27 - 2 hours:24 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140213_AP4_6h_24_restart SUBJECT_SAMPLE_FACTORS - HP_140213_AP4_6h_24_restart_#37 - 12 hours:24 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140213_AP4_6h_24_restart SUBJECT_SAMPLE_FACTORS - HP_140227_AP5_24h_48h_#42 - 2 hours:24 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140227_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140227_AP5_24h_48h_#52 - 12 hours:24 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140227_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140314_AP6_24h_#16 - 2 hours:24 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140314_AP6_24h SUBJECT_SAMPLE_FACTORS - HP_140314_AP6_24h_#26 - 12 hours:24 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140314_AP6_24h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4and5_48h_10min_#45 - 5 hours:48 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140214_AP4and5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140228_AP5_24h_48h_#19 - 5 hours:48 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140228_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140321_Betti_AP6_48h_#58 - 5 hours:48 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140321_Betti_AP6_48h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4and5_48h_10min_#46 - 6 hours:48 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140214_AP4and5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140228_AP5_24h_48h_#20 - 6 hours:48 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140228_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140321_Betti_AP6_48h_#59 - 6 hours:48 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140321_Betti_AP6_48h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4and5_48h_10min_#50 - 10 hours:48 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140214_AP4and5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140228_AP5_24h_48h_#24 - 10 hours:48 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140228_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140321_Betti_AP6_48h_#63 - 10 hours:48 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140321_Betti_AP6_48h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4and5_48h_10min_#49 - 9 hours:48 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140214_AP4and5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140228_AP5_24h_48h_#23 - 9 hours:48 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140228_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140321_Betti_AP6_48h_#62 - 9 hours:48 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140321_Betti_AP6_48h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4and5_48h_10min_#44 - 4 hours:48 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140214_AP4and5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140228_AP5_24h_48h_#18 - 4 hours:48 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140228_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140321_Betti_AP6_48h_#57 - 4 hours:48 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140321_Betti_AP6_48h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4and5_48h_10min_#43 - 3 hours:48 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140214_AP4and5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140228_AP5_24h_48h_#17 - 3 hours:48 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140228_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140321_Betti_AP6_48h_#56 - 3 hours:48 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140321_Betti_AP6_48h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4and5_48h_10min_#47 - 7 hours:48 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140214_AP4and5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140228_AP5_24h_48h_#21 - 7 hours:48 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140228_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140321_Betti_AP6_48h_#60 - 7 hours:48 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140321_Betti_AP6_48h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4and5_48h_10min_#48 - 8 hours:48 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140214_AP4and5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140228_AP5_24h_48h_#22 - 8 hours:48 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140228_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140321_Betti_AP6_48h_#61 - 8 hours:48 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140321_Betti_AP6_48h SUBJECT_SAMPLE_FACTORS - HP_140214_AP4and5_48h_10min_#42 - 2 hours:48 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140214_AP4and5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140214_AP4and5_48h_10min_#52 - 12 hours:48 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140214_AP4and5_48h_10min SUBJECT_SAMPLE_FACTORS - HP_140228_AP5_24h_48h_#16 - 2 hours:48 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140228_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140228_AP5_24h_48h_#26 - 12 hours:48 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140228_AP5_24h_48h SUBJECT_SAMPLE_FACTORS - HP_140321_Betti_AP6_48h_#55 - 2 hours:48 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140321_Betti_AP6_48h SUBJECT_SAMPLE_FACTORS - HP_140321_Betti_AP6_48h_#65 - 12 hours:48 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140321_Betti_AP6_48h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_6h_24h_#45 - 5 hours:6 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140211_AP4_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#110 - 5 hours:6 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140313_AP6_6h_24h_#45 - 5 hours:6 | treatment:CHX | concentration:20 µg/ml RAW_FILE_NAME=HP_140313_AP6_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_6h_24h_#46 - 6 hours:6 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140211_AP4_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#111 - 6 hours:6 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140313_AP6_6h_24h_#46 - 6 hours:6 | treatment:ETO | concentration:10 µM RAW_FILE_NAME=HP_140313_AP6_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_6h_24h_#50 - 10 hours:6 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140211_AP4_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#115 - 10 hours:6 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140313_AP6_6h_24h_#50 - 10 hours:6 | treatment:MC | concentration:10 µM RAW_FILE_NAME=HP_140313_AP6_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_6h_24h_#49 - 9 hours:6 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140211_AP4_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#114 - 9 hours:6 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140313_AP6_6h_24h_#49 - 9 hours:6 | treatment:Serum | concentration:- RAW_FILE_NAME=HP_140313_AP6_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_6h_24h_#44 - 4 hours:6 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140211_AP4_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#109 - 4 hours:6 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140313_AP6_6h_24h_#44 - 4 hours:6 | treatment:STS | concentration:0.3 µM RAW_FILE_NAME=HP_140313_AP6_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_6h_24h_#43 - 3 hours:6 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140211_AP4_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#108 - 3 hours:6 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140313_AP6_6h_24h_#43 - 3 hours:6 | treatment:TNFα | concentration:10 ng/ml RAW_FILE_NAME=HP_140313_AP6_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_6h_24h_#47 - 7 hours:6 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140211_AP4_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#112 - 7 hours:6 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140313_AP6_6h_24h_#47 - 7 hours:6 | treatment:TPG | concentration:2 µM RAW_FILE_NAME=HP_140313_AP6_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_6h_24h_#48 - 8 hours:6 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140211_AP4_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#113 - 8 hours:6 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140313_AP6_6h_24h_#48 - 8 hours:6 | treatment:VAL | concentration:10 µM RAW_FILE_NAME=HP_140313_AP6_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_6h_24h_#42 - 2 hours:6 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140211_AP4_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140211_AP4_6h_24h_#52 - 12 hours:6 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140211_AP4_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#107 - 2 hours:6 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140217_AP5_1h_6h_#117 - 12 hours:6 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140217_AP5_1h_6h SUBJECT_SAMPLE_FACTORS - HP_140313_AP6_6h_24h_#42 - 2 hours:6 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140313_AP6_6h_24h SUBJECT_SAMPLE_FACTORS - HP_140313_AP6_6h_24h_#52 - 12 hours:6 | treatment:vehicle (DMSO) | concentration:- RAW_FILE_NAME=HP_140313_AP6_6h_24h #COLLECTION CO:COLLECTION_SUMMARY Cultured cells were washed, trypsinized, counted and flash-frozen in liquid N2 CO:COLLECTION_SUMMARY and stored at -80°C. CO:SAMPLE_TYPE Fibroblasts CO:COLLECTION_METHOD Trypsinization of cultured cells CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY Mouse NIH-3T3 fibroblasts were cultivated in DMEM high glucose medium containing TR:TREATMENT_SUMMARY heat-inactivated fetal calf serum (FCS, 10%). After cultivation for 24 h, cells TR:TREATMENT_SUMMARY were treated with vehicle, TNFα (10 ng/ml), STS (0.3 µM), CHX (20 µg/ml), ETO TR:TREATMENT_SUMMARY (10 µM), TPG (2 µM), VAL (10 µM), MC (10 µM) at 37°C and 5% CO2. Serum TR:TREATMENT_SUMMARY depletion of NIH-3T3 fibroblasts was achieved by cultivation of cells in TR:TREATMENT_SUMMARY serum-free DMEM. TR:TREATMENT_VEHICLE DMSO TR:CELL_MEDIA DMEM + 10% FCS TR:CELL_ENVIR_COND 37°C, 5% CO2 #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Phospholipids were extracted from cell pellets by successive addition of PBS pH SP:SAMPLEPREP_SUMMARY 7.4, methanol, chloroform, and saline to a final ratio of 14:34:35:17. SP:SAMPLEPREP_SUMMARY Evaporation of the organic layer yielded a lipid film that was dissolved in SP:SAMPLEPREP_SUMMARY methanol and subjected to UPLC-MS/MS. SP:EXTRACT_STORAGE -20℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Chromatographic separation of phospholipids was carried out on an Acquity BEH C8 CH:CHROMATOGRAPHY_SUMMARY column (1.7 μm, 2.1×100 mm, Waters, Milford, MA) using an Acquity UHPLC. CH:INSTRUMENT_NAME Waters Acquity H-Class CH:COLUMN_NAME Waters Acquity BEH C8 (100 x 2.1mm, 1.7um) CH:CHROMATOGRAPHY_TYPE Reversed phase #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME ABI Sciex 5500 QTrap MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:MS_COMMENTS Targeted MRM with pre-optimized settings and subsequent automated integration of MS:MS_COMMENTS selected signals using Analyst 1.6 (Sciex). MS:ION_MODE NEGATIVE #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Relative intensity MS_METABOLITE_DATA_START Samples HP_140211_AP4_10m_1h_#45 - 5 HP_140214_AP4und5_48h_10min_#10 - 5 HP_140311_AP6_10min_#45 - 5 HP_140211_AP4_10m_1h_#46 - 6 HP_140214_AP4und5_48h_10min_#11 - 6 HP_140311_AP6_10min_#46 - 6 HP_140211_AP4_10m_1h_#50 - 10 HP_140214_AP4und5_48h_10min_#15 - 10 HP_140311_AP6_10min_#50 - 10 HP_140211_AP4_10m_1h_#49 - 9 HP_140214_AP4und5_48h_10min_#14 - 9 HP_140311_AP6_10min_#49 - 9 HP_140211_AP4_10m_1h_#44 - 4 HP_140214_AP4und5_48h_10min_#9 - 4 HP_140311_AP6_10min_#44 - 4 HP_140211_AP4_10m_1h_#43 - 3 HP_140214_AP4und5_48h_10min_#8 - 3 HP_140311_AP6_10min_#43 - 3 HP_140211_AP4_10m_1h_#47 - 7 HP_140214_AP4und5_48h_10min_#12 - 7 HP_140311_AP6_10min_#47 - 7 HP_140211_AP4_10m_1h_#48 - 8 HP_140214_AP4und5_48h_10min_#13 - 8 HP_140311_AP6_10min_#48 - 8 HP_140211_AP4_10m_1h_#42 - 2 HP_140211_AP4_10m_1h_#52 - 12 HP_140214_AP4und5_48h_10min_#17 - 12 HP_140214_AP4und5_48h_10min_#7 - 2 HP_140311_AP6_10min_#42 - 2 HP_140311_AP6_10min_#52 - 12 HP_140211_AP4_10min_1h_#10 - 5 HP_140217_AP5_1h_6h_#45 - 5 HP_140312_AP6_1h_#45 - 5 HP_140211_AP4_10min_1h_#11 - 6 HP_140217_AP5_1h_6h_#46 - 6 HP_140312_AP6_1h_#46 - 6 HP_140211_AP4_10min_1h_#15 - 10 HP_140217_AP5_1h_6h_#50 - 10 HP_140312_AP6_1h_#50 - 10 HP_140211_AP4_10min_1h_#14 - 9 HP_140217_AP5_1h_6h_#49 - 9 HP_140312_AP6_1h_#49 - 9 HP_140211_AP4_10min_1h_#9 - 4 HP_140217_AP5_1h_6h_#44 - 4 HP_140312_AP6_1h_#44 - 4 HP_140211_AP4_10min_1h_#8 - 3 HP_140217_AP5_1h_6h_#43 - 3 HP_140312_AP6_1h_#43 - 3 HP_140211_AP4_10min_1h_#12 - 7 HP_140217_AP5_1h_6h_#47 - 7 HP_140312_AP6_1h_#47 - 7 HP_140211_AP4_10min_1h_#13 - 8 HP_140217_AP5_1h_6h_#48 - 8 HP_140312_AP6_1h_#48 - 8 HP_140211_AP4_10min_1h_#17 - 12 HP_140211_AP4_10min_1h_#7 - 2 HP_140217_AP5_1h_6h_#42 - 2 HP_140217_AP5_1h_6h_#52 - 12 HP_140312_AP6_1h_#42 - 2 HP_140312_AP6_1h_#52 - 12 HP_140213_AP4_6h_24_restart_#30 - 5 HP_140227_AP5_24h_48h_#45 - 5 HP_140314_AP6_24h_#19 - 5 HP_140213_AP4_6h_24_restart_#31 - 6 HP_140227_AP5_24h_48h_#46 - 6 HP_140314_AP6_24h_#20 - 6 HP_140213_AP4_6h_24_restart_#35 - 10 HP_140227_AP5_24h_48h_#50 - 10 HP_140314_AP6_24h_#24 - 10 HP_140213_AP4_6h_24_restart_#34 - 9 HP_140227_AP5_24h_48h_#49 - 9 HP_140314_AP6_24h_#23 - 9 HP_140213_AP4_6h_24_restart_#29 - 4 HP_140227_AP5_24h_48h_#44 - 4 HP_140314_AP6_24h_#18 - 4 HP_140213_AP4_6h_24_restart_#28 - 3 HP_140227_AP5_24h_48h_#43 - 3 HP_140314_AP6_24h_#17 - 3 HP_140213_AP4_6h_24_restart_#32 - 7 HP_140227_AP5_24h_48h_#47 - 7 HP_140314_AP6_24h_#21 - 7 HP_140213_AP4_6h_24_restart_#33 - 8 HP_140227_AP5_24h_48h_#48 - 8 HP_140314_AP6_24h_#22 - 8 HP_140213_AP4_6h_24_restart_#27 - 2 HP_140213_AP4_6h_24_restart_#37 - 12 HP_140227_AP5_24h_48h_#42 - 2 HP_140227_AP5_24h_48h_#52 - 12 HP_140314_AP6_24h_#16 - 2 HP_140314_AP6_24h_#26 - 12 HP_140214_AP4and5_48h_10min_#45 - 5 HP_140228_AP5_24h_48h_#19 - 5 HP_140321_Betti_AP6_48h_#58 - 5 HP_140214_AP4and5_48h_10min_#46 - 6 HP_140228_AP5_24h_48h_#20 - 6 HP_140321_Betti_AP6_48h_#59 - 6 HP_140214_AP4and5_48h_10min_#50 - 10 HP_140228_AP5_24h_48h_#24 - 10 HP_140321_Betti_AP6_48h_#63 - 10 HP_140214_AP4and5_48h_10min_#49 - 9 HP_140228_AP5_24h_48h_#23 - 9 HP_140321_Betti_AP6_48h_#62 - 9 HP_140214_AP4and5_48h_10min_#44 - 4 HP_140228_AP5_24h_48h_#18 - 4 HP_140321_Betti_AP6_48h_#57 - 4 HP_140214_AP4and5_48h_10min_#43 - 3 HP_140228_AP5_24h_48h_#17 - 3 HP_140321_Betti_AP6_48h_#56 - 3 HP_140214_AP4and5_48h_10min_#47 - 7 HP_140228_AP5_24h_48h_#21 - 7 HP_140321_Betti_AP6_48h_#60 - 7 HP_140214_AP4and5_48h_10min_#48 - 8 HP_140228_AP5_24h_48h_#22 - 8 HP_140321_Betti_AP6_48h_#61 - 8 HP_140214_AP4and5_48h_10min_#42 - 2 HP_140214_AP4and5_48h_10min_#52 - 12 HP_140228_AP5_24h_48h_#16 - 2 HP_140228_AP5_24h_48h_#26 - 12 HP_140321_Betti_AP6_48h_#55 - 2 HP_140321_Betti_AP6_48h_#65 - 12 HP_140211_AP4_6h_24h_#45 - 5 HP_140217_AP5_1h_6h_#110 - 5 HP_140313_AP6_6h_24h_#45 - 5 HP_140211_AP4_6h_24h_#46 - 6 HP_140217_AP5_1h_6h_#111 - 6 HP_140313_AP6_6h_24h_#46 - 6 HP_140211_AP4_6h_24h_#50 - 10 HP_140217_AP5_1h_6h_#115 - 10 HP_140313_AP6_6h_24h_#50 - 10 HP_140211_AP4_6h_24h_#49 - 9 HP_140217_AP5_1h_6h_#114 - 9 HP_140313_AP6_6h_24h_#49 - 9 HP_140211_AP4_6h_24h_#44 - 4 HP_140217_AP5_1h_6h_#109 - 4 HP_140313_AP6_6h_24h_#44 - 4 HP_140211_AP4_6h_24h_#43 - 3 HP_140217_AP5_1h_6h_#108 - 3 HP_140313_AP6_6h_24h_#43 - 3 HP_140211_AP4_6h_24h_#47 - 7 HP_140217_AP5_1h_6h_#112 - 7 HP_140313_AP6_6h_24h_#47 - 7 HP_140211_AP4_6h_24h_#48 - 8 HP_140217_AP5_1h_6h_#113 - 8 HP_140313_AP6_6h_24h_#48 - 8 HP_140211_AP4_6h_24h_#42 - 2 HP_140211_AP4_6h_24h_#52 - 12 HP_140217_AP5_1h_6h_#107 - 2 HP_140217_AP5_1h_6h_#117 - 12 HP_140313_AP6_6h_24h_#42 - 2 HP_140313_AP6_6h_24h_#52 - 12 Factors hours:0.17 | treatment:CHX | concentration:20 µg/ml hours:0.17 | treatment:CHX | concentration:20 µg/ml hours:0.17 | treatment:CHX | concentration:20 µg/ml hours:0.17 | treatment:ETO | concentration:10 µM hours:0.17 | treatment:ETO | concentration:10 µM hours:0.17 | treatment:ETO | concentration:10 µM hours:0.17 | treatment:MC | concentration:10 µM hours:0.17 | treatment:MC | concentration:10 µM hours:0.17 | treatment:MC | concentration:10 µM hours:0.17 | treatment:Serum | concentration:- hours:0.17 | treatment:Serum | concentration:- hours:0.17 | treatment:Serum | concentration:- hours:0.17 | treatment:STS | concentration:0.3 µM hours:0.17 | treatment:STS | concentration:0.3 µM hours:0.17 | treatment:STS | concentration:0.3 µM hours:0.17 | treatment:TNFα | concentration:10 ng/ml hours:0.17 | treatment:TNFα | concentration:10 ng/ml hours:0.17 | treatment:TNFα | concentration:10 ng/ml hours:0.17 | treatment:TPG | concentration:2 µM hours:0.17 | treatment:TPG | concentration:2 µM hours:0.17 | treatment:TPG | concentration:2 µM hours:0.17 | treatment:VAL | concentration:10 µM hours:0.17 | treatment:VAL | concentration:10 µM hours:0.17 | treatment:VAL | concentration:10 µM hours:0.17 | treatment:vehicle (DMSO) | concentration:- hours:0.17 | treatment:vehicle (DMSO) | concentration:- hours:0.17 | treatment:vehicle (DMSO) | concentration:- hours:0.17 | treatment:vehicle (DMSO) | concentration:- hours:0.17 | treatment:vehicle (DMSO) | concentration:- hours:0.17 | treatment:vehicle (DMSO) | concentration:- hours:1 | treatment:CHX | concentration:20 µg/ml hours:1 | treatment:CHX | concentration:20 µg/ml hours:1 | treatment:CHX | concentration:20 µg/ml hours:1 | treatment:ETO | concentration:10 µM hours:1 | treatment:ETO | concentration:10 µM hours:1 | treatment:ETO | concentration:10 µM hours:1 | treatment:MC | concentration:10 µM hours:1 | treatment:MC | concentration:10 µM hours:1 | treatment:MC | concentration:10 µM hours:1 | treatment:Serum | concentration:- hours:1 | treatment:Serum | concentration:- hours:1 | treatment:Serum | concentration:- hours:1 | treatment:STS | concentration:0.3 µM hours:1 | treatment:STS | concentration:0.3 µM hours:1 | treatment:STS | concentration:0.3 µM hours:1 | treatment:TNFα | concentration:10 ng/ml hours:1 | treatment:TNFα | concentration:10 ng/ml hours:1 | treatment:TNFα | concentration:10 ng/ml hours:1 | treatment:TPG | concentration:2 µM hours:1 | treatment:TPG | concentration:2 µM hours:1 | treatment:TPG | concentration:2 µM hours:1 | treatment:VAL | concentration:10 µM hours:1 | treatment:VAL | concentration:10 µM hours:1 | treatment:VAL | concentration:10 µM hours:1 | treatment:vehicle (DMSO) | concentration:- hours:1 | treatment:vehicle (DMSO) | concentration:- hours:1 | treatment:vehicle (DMSO) | concentration:- hours:1 | treatment:vehicle (DMSO) | concentration:- hours:1 | treatment:vehicle (DMSO) | concentration:- hours:1 | treatment:vehicle (DMSO) | concentration:- hours:24 | treatment:CHX | concentration:20 µg/ml hours:24 | treatment:CHX | concentration:20 µg/ml hours:24 | treatment:CHX | concentration:20 µg/ml hours:24 | treatment:ETO | concentration:10 µM hours:24 | treatment:ETO | concentration:10 µM hours:24 | treatment:ETO | concentration:10 µM hours:24 | treatment:MC | concentration:10 µM hours:24 | treatment:MC | concentration:10 µM hours:24 | treatment:MC | concentration:10 µM hours:24 | treatment:Serum | concentration:- hours:24 | treatment:Serum | concentration:- hours:24 | treatment:Serum | concentration:- hours:24 | treatment:STS | concentration:0.3 µM hours:24 | treatment:STS | concentration:0.3 µM hours:24 | treatment:STS | concentration:0.3 µM hours:24 | treatment:TNFα | concentration:10 ng/ml hours:24 | treatment:TNFα | concentration:10 ng/ml hours:24 | treatment:TNFα | concentration:10 ng/ml hours:24 | treatment:TPG | concentration:2 µM hours:24 | treatment:TPG | concentration:2 µM hours:24 | treatment:TPG | concentration:2 µM hours:24 | treatment:VAL | concentration:10 µM hours:24 | treatment:VAL | concentration:10 µM hours:24 | treatment:VAL | concentration:10 µM hours:24 | treatment:vehicle (DMSO) | concentration:- hours:24 | treatment:vehicle (DMSO) | concentration:- hours:24 | treatment:vehicle (DMSO) | concentration:- hours:24 | treatment:vehicle (DMSO) | concentration:- hours:24 | treatment:vehicle (DMSO) | concentration:- hours:24 | treatment:vehicle (DMSO) | concentration:- hours:48 | treatment:CHX | concentration:20 µg/ml hours:48 | treatment:CHX | concentration:20 µg/ml hours:48 | treatment:CHX | concentration:20 µg/ml hours:48 | treatment:ETO | concentration:10 µM hours:48 | treatment:ETO | concentration:10 µM hours:48 | treatment:ETO | concentration:10 µM hours:48 | treatment:MC | concentration:10 µM hours:48 | treatment:MC | concentration:10 µM hours:48 | treatment:MC | concentration:10 µM hours:48 | treatment:Serum | concentration:- hours:48 | treatment:Serum | concentration:- hours:48 | treatment:Serum | concentration:- hours:48 | treatment:STS | concentration:0.3 µM hours:48 | treatment:STS | concentration:0.3 µM hours:48 | treatment:STS | concentration:0.3 µM hours:48 | treatment:TNFα | concentration:10 ng/ml hours:48 | treatment:TNFα | concentration:10 ng/ml hours:48 | treatment:TNFα | concentration:10 ng/ml hours:48 | treatment:TPG | concentration:2 µM hours:48 | treatment:TPG | concentration:2 µM hours:48 | treatment:TPG | concentration:2 µM hours:48 | treatment:VAL | concentration:10 µM hours:48 | treatment:VAL | concentration:10 µM hours:48 | treatment:VAL | concentration:10 µM hours:48 | treatment:vehicle (DMSO) | concentration:- hours:48 | treatment:vehicle (DMSO) | concentration:- hours:48 | treatment:vehicle (DMSO) | concentration:- hours:48 | treatment:vehicle (DMSO) | concentration:- hours:48 | treatment:vehicle (DMSO) | concentration:- hours:48 | treatment:vehicle (DMSO) | concentration:- hours:6 | treatment:CHX | concentration:20 µg/ml hours:6 | treatment:CHX | concentration:20 µg/ml hours:6 | treatment:CHX | concentration:20 µg/ml hours:6 | treatment:ETO | concentration:10 µM hours:6 | treatment:ETO | concentration:10 µM hours:6 | treatment:ETO | concentration:10 µM hours:6 | treatment:MC | concentration:10 µM hours:6 | treatment:MC | concentration:10 µM hours:6 | treatment:MC | concentration:10 µM hours:6 | treatment:Serum | concentration:- hours:6 | treatment:Serum | concentration:- hours:6 | treatment:Serum | concentration:- hours:6 | treatment:STS | concentration:0.3 µM hours:6 | treatment:STS | concentration:0.3 µM hours:6 | treatment:STS | concentration:0.3 µM hours:6 | treatment:TNFα | concentration:10 ng/ml hours:6 | treatment:TNFα | concentration:10 ng/ml hours:6 | treatment:TNFα | concentration:10 ng/ml hours:6 | treatment:TPG | concentration:2 µM hours:6 | treatment:TPG | concentration:2 µM hours:6 | treatment:TPG | concentration:2 µM hours:6 | treatment:VAL | concentration:10 µM hours:6 | treatment:VAL | concentration:10 µM hours:6 | treatment:VAL | concentration:10 µM hours:6 | treatment:vehicle (DMSO) | concentration:- hours:6 | treatment:vehicle (DMSO) | concentration:- hours:6 | treatment:vehicle (DMSO) | concentration:- hours:6 | treatment:vehicle (DMSO) | concentration:- hours:6 | treatment:vehicle (DMSO) | concentration:- hours:6 | treatment:vehicle (DMSO) | concentration:- Phosphatidylinositol(16:0/18:1) 1.2670 0.6480 0.7330 1.1430 1.0750 0.9030 1.1220 0.5000 0.6880 0.7580 0.6050 0.3840 1.7970 1.0030 1.1950 2.2830 1.5260 1.1580 3.5410 3.0020 3.9760 1.3820 1.0210 1.6610 1.5080 1.1000 0.8890 1.0060 1.4210 0.6510 0.6500 0.9740 0.4190 1.1370 1.1680 0.7690 0.9760 0.6650 1.2420 0.9300 0.5770 0.5900 1.0620 0.5580 0.4660 4.1260 1.9120 2.4160 3.9210 3.3940 3.1910 2.2760 0.9280 2.2330 1.0500 1.9810 1.0750 1.0610 0.9480 1.3700 1.4950 0.4860 1.3970 1.9790 1.3400 1.7470 1.7180 2.0360 4.8610 0.9820 1.1320 0.5460 0.8310 1.3240 0.7620 2.0070 3.1500 2.3580 3.6690 3.9970 5.1070 12.0160 8.0320 12.1230 1.2790 1.4800 2.7640 0.9860 2.4210 1.7300 2.0480 2.0550 1.4970 4.0960 2.4020 4.3410 1.9680 2.3410 6.8800 0.6580 0.6180 1.2930 1.2670 1.4420 1.1240 4.4210 4.9010 4.6110 1.6330 4.1260 4.2230 8.2330 5.5110 8.8990 3.4310 4.4330 3.7750 2.5620 3.5590 3.8940 0.4870 0.9280 1.5960 1.1940 0.5950 0.8370 1.4330 1.1170 2.3700 1.7880 1.2610 1.4650 1.2120 0.7750 1.2650 2.2150 1.1510 1.5910 3.9780 3.9630 4.9790 7.7640 7.8270 7.9660 1.2010 0.7720 0.9820 0.7390 0.8330 1.2000 Phosphatidylinositol(16:0/20:3 n-6) 1.1260 0.6910 0.6190 0.8350 0.7980 1.2260 1.0120 0.8090 0.7560 0.7850 0.6260 0.9580 0.7370 0.8530 0.5520 0.7760 0.8760 0.5200 0.7960 0.4220 1.1450 1.0080 0.4980 0.6440 1.0580 0.6990 0.7790 0.5190 0.5260 0.5220 0.5940 0.7390 0.9760 0.7810 0.7480 0.4910 0.8100 0.6350 0.5200 0.8620 0.4260 0.7200 0.6760 0.3360 0.4660 1.1830 0.7650 0.7590 1.5070 0.9260 1.0450 1.0840 0.6880 0.9610 0.6460 1.2700 0.6750 0.3780 0.7600 0.5640 0.5290 0.8030 0.3500 0.9780 0.6510 0.7170 1.1080 1.0420 2.5080 0.6140 0.5290 0.4560 0.6340 0.8680 0.4350 1.0460 0.7390 0.7250 1.6880 1.2760 1.7440 2.4920 2.4130 2.5600 0.7880 0.8260 0.7150 0.4150 0.7690 1.1950 0.6170 0.5470 0.5450 1.4950 1.0890 1.7150 1.1220 1.2640 1.5700 0.2750 0.4410 0.3650 0.5800 0.3710 0.3990 1.4650 0.7260 0.7930 0.9210 1.2540 1.1990 2.5820 2.3170 2.6510 0.8140 1.1280 0.6590 0.5770 0.7710 0.5130 0.6490 0.5630 0.5320 0.6710 0.5000 0.8370 0.8570 0.6640 1.2540 0.5080 0.4780 1.0280 0.9640 0.5870 0.6330 1.1490 0.9660 0.7700 1.5570 1.3450 1.6080 2.0930 1.7410 2.4170 0.6530 0.9440 0.6810 0.6340 0.7300 0.5650 Phosphatidylinositol(16:0/20:4) 5.1440 5.3630 6.7700 6.0730 5.0300 5.5450 5.4990 5.2580 5.6580 5.9850 5.6120 6.9020 5.3020 5.2330 6.1530 4.7120 5.8880 4.6280 6.2720 5.9740 6.5230 6.1970 5.9740 6.3240 6.1680 6.1120 4.7740 4.8890 6.3760 6.7100 5.3260 4.1100 4.8220 5.3680 4.4050 6.5130 5.6840 6.0520 6.0990 5.6470 5.6700 5.6970 5.7870 4.2530 6.0360 4.8750 4.4850 4.0020 6.3430 5.4860 5.9040 5.8340 6.2360 6.1820 5.9710 5.5200 5.1600 5.1130 5.9010 6.9730 3.2700 2.9880 4.1290 5.1720 5.1020 6.0820 4.5350 3.3340 5.3560 4.0850 4.4370 3.4490 5.5230 5.7600 6.4670 5.6730 5.1820 5.2620 4.0150 4.6560 4.7090 4.5740 4.1730 4.3410 5.9720 5.8170 5.6020 4.2590 6.1610 5.7560 3.6050 3.3850 4.7700 6.3070 5.2900 6.7060 4.2060 4.2400 5.1170 3.3010 3.3200 2.9520 6.3570 5.4810 6.8330 5.6150 4.4940 5.1870 4.1850 3.9680 3.8730 5.2980 4.8990 5.0530 6.2060 5.3830 5.3780 5.3180 4.5040 5.2870 4.9910 5.0130 5.6280 6.7680 3.7670 7.1250 5.2860 4.5010 7.0550 5.1440 4.4580 4.1860 6.7780 5.6130 5.2620 5.7210 5.0310 5.9040 4.2120 4.6940 5.3600 5.6680 5.7980 6.2740 5.4160 6.4520 5.4470 5.0450 6.8700 6.5040 Phosphatidylinositol(16:1/18:1) 1.1690 0.9120 1.0840 1.3370 0.8840 0.7830 1.1700 0.9130 1.0390 0.9590 0.8010 0.9690 1.9370 1.7130 1.3100 2.7870 1.6560 1.5210 3.5610 3.9660 3.2250 1.4560 1.0210 1.1420 1.9530 1.0630 0.8570 1.5670 1.5710 1.0520 0.9140 1.0700 0.7770 1.2140 1.2250 1.0600 1.1700 0.7960 1.0490 1.4900 0.8520 0.8620 1.0720 0.9710 1.2370 3.6590 1.7590 2.5620 3.5400 3.5220 3.6430 1.5390 0.8380 1.0830 0.9820 2.2240 1.1790 0.5540 1.4260 1.2760 0.9040 1.2610 0.9390 1.8810 1.6740 2.1500 1.9010 2.3430 4.1800 1.3790 1.4580 1.2850 0.7620 1.3540 0.6090 2.2460 2.9600 2.3040 3.3230 3.5580 3.6250 3.4820 3.1500 3.2400 1.9770 1.9560 2.7320 1.7490 2.3140 2.6340 0.9240 1.0300 1.3850 3.3560 2.4500 1.7260 2.3860 2.6010 4.8200 1.3470 2.1370 1.1330 1.0490 1.7390 1.3730 4.4600 4.7160 5.6700 1.3470 2.2970 2.0390 1.4490 2.1520 2.2460 4.0930 5.0550 4.5620 3.4410 4.5040 4.2740 0.8180 1.1040 1.4330 1.3660 0.9070 0.8500 1.3830 1.5530 3.5580 1.8550 1.2830 0.6060 1.3720 0.6390 0.9950 2.3930 1.6420 2.2080 3.8560 3.3660 2.4480 2.9770 3.0430 2.5000 1.1490 1.1630 1.3670 0.9890 1.3650 0.9070 Phosphatidylinositol(18:0/20:3 n-6) 4.5010 5.0640 3.9450 6.0370 6.1320 4.3190 4.7780 5.4020 4.9440 5.2690 4.6740 3.9480 5.5320 5.0810 4.9620 6.8610 5.6820 4.3280 5.9180 4.0270 3.7190 6.1860 4.4760 4.4480 6.3830 5.9830 5.4470 4.6770 5.2600 4.0320 5.0780 4.7340 4.3090 5.6180 5.6580 4.8470 5.1120 4.7980 5.5610 5.7550 5.0780 5.1580 5.2220 5.5340 6.0360 6.4060 5.1230 6.6890 5.7500 4.1910 5.1060 7.2180 5.1370 6.5400 4.8250 5.9160 4.2510 5.8540 4.6720 4.7970 5.8320 5.7810 5.4640 5.7480 5.4460 5.4230 8.5380 10.3250 9.1650 6.2870 5.5140 6.9930 4.5290 5.5450 5.1030 5.9180 4.8010 5.6430 11.8980 10.8430 9.6110 16.2150 14.4650 12.6150 6.3060 6.2710 5.3180 6.7250 5.4750 4.9810 7.2380 7.4650 8.0770 7.6860 6.8640 7.1650 9.2890 9.2600 11.8240 5.1060 5.8960 5.7210 3.5370 5.0600 4.4050 5.8150 4.6690 4.3610 14.8000 12.9400 13.5930 16.3360 15.7890 13.4110 6.9090 6.3900 4.7490 5.6010 5.0970 6.5850 4.1480 5.4750 4.7840 5.2940 4.0860 5.3830 5.8290 7.2410 7.2360 6.6620 5.3280 5.5820 5.2320 5.2070 6.1140 7.1430 5.6350 5.2380 9.4530 7.2560 8.1060 13.4800 9.8430 12.0250 6.3100 5.9800 4.2230 6.4160 5.7220 4.8550 Phosphatidylinositol(18:0/20:4) 58.5620 58.0210 56.0090 52.8970 58.0490 56.5680 58.8970 56.5910 56.8810 60.3370 57.5640 54.6660 53.2780 54.0700 52.4040 49.4720 50.5470 53.2890 41.5790 40.0670 38.8420 53.9980 55.3400 53.9730 52.9240 57.2420 59.4370 52.3720 51.0090 56.6690 59.8430 60.2660 60.2700 58.1090 58.3980 56.9520 57.5720 57.2560 55.1570 58.1380 59.9840 58.6680 58.9420 59.2040 57.6810 40.3910 50.5170 43.6000 37.0900 37.7760 38.2960 53.8810 59.3890 55.3910 58.3650 52.9490 56.3600 59.1300 53.8240 56.3770 69.3810 67.9870 65.2130 52.7030 54.9290 47.4520 48.5740 43.7880 30.1880 66.8500 60.6830 67.5730 66.3580 59.3900 61.6170 49.2630 38.4260 38.7140 44.6660 32.1730 32.5390 24.5790 21.0720 19.4130 52.9920 52.1460 40.6540 57.3900 44.2550 45.9360 66.4840 62.5290 63.6720 45.3200 52.0900 45.8830 44.6260 40.1860 29.7330 70.5310 64.1150 66.2210 65.8400 64.4530 62.7770 37.9480 30.9750 29.9070 52.2600 37.3010 36.9810 34.2820 34.0940 26.4060 43.0940 39.4930 36.9050 47.4320 35.5870 39.5760 65.8480 59.4970 54.7430 57.8840 65.3570 53.3800 53.5970 52.4470 40.0990 61.2190 61.1070 59.6240 64.0170 63.0320 61.1350 47.1450 48.9410 48.1630 37.0370 36.4460 32.7530 38.8210 38.9450 36.9060 57.9230 56.8720 53.8630 58.5250 54.0630 54.9650 Phosphatidylinositol(18:0/22:5) 1.8070 2.1580 2.0850 2.9520 2.2390 1.4820 2.2940 1.8830 2.4810 2.1610 1.5250 2.2360 2.3070 2.2150 1.2860 2.7200 2.1320 2.3740 2.2960 1.9980 1.8690 2.7530 2.0970 1.3410 2.6530 1.9940 2.1150 2.1270 1.5800 2.4130 2.2060 2.1490 1.8800 1.8700 2.0610 2.3140 2.0270 2.3010 1.8650 1.9510 2.0390 2.0970 2.1630 2.1240 1.6260 4.2670 2.2430 3.0460 2.5660 2.0390 2.3990 3.2020 2.3680 2.3120 1.4930 2.3140 2.2280 1.8230 1.1390 1.8300 2.0040 2.0510 1.5710 2.2290 2.1440 2.3820 2.9820 3.0450 4.3660 1.6580 2.3390 2.1610 2.2600 1.9500 2.1210 2.3070 1.4760 1.7310 4.5530 3.6070 3.5560 9.3370 9.4930 10.6900 2.1890 2.0310 1.3740 2.0220 1.3720 2.0450 2.4270 2.1880 2.1810 2.5390 2.5150 2.6120 3.6400 3.1600 2.8830 2.1940 1.7210 1.4760 2.0190 1.8570 2.0880 2.0780 1.3500 1.1880 5.8790 4.3970 4.3230 7.5840 7.2320 7.4540 1.9500 1.9860 1.5370 1.7800 1.1570 1.2440 2.1440 2.0560 1.5990 2.1630 2.4800 1.7780 2.3710 2.4140 1.8090 2.8160 2.2180 2.6390 1.7080 2.3040 2.0380 3.6250 2.1250 2.6190 4.0290 2.6230 2.5640 6.5970 4.4960 5.6900 2.3430 2.2520 1.6090 2.6520 1.6170 2.6140 Phosphatidylinositol(18:0/22:6) 1.0860 1.2330 1.1830 1.9760 1.5140 1.1590 1.2060 1.3790 0.7560 1.3600 1.1460 0.5110 1.2100 1.5570 0.8260 1.6570 1.5480 1.2830 1.7300 1.4100 1.2700 1.8920 1.1890 1.0190 1.3090 1.4660 1.2980 1.6170 1.1340 0.5220 1.2030 1.1090 1.6030 1.3110 1.2630 1.3330 1.3450 1.6340 1.5560 1.3820 0.9140 1.1140 1.2670 1.6240 1.0090 2.5620 1.0930 2.8280 1.8880 1.5350 1.3540 2.0410 1.4620 1.8190 0.9140 1.4320 1.1790 1.4060 1.0110 0.8010 1.1560 0.7850 0.8740 1.6000 1.1220 1.1640 2.5200 3.0810 2.7220 1.1660 1.0570 1.2730 0.9680 1.5720 1.0350 2.0680 1.1640 1.1680 2.4590 2.0980 2.0730 9.0810 7.5460 7.7410 1.6010 1.4800 1.0160 1.4010 1.0900 0.8330 1.3310 1.2990 0.4090 2.3210 1.4990 0.6390 2.1170 1.6780 2.5580 1.0970 0.6180 0.1840 1.4100 0.6510 0.4820 1.7300 1.0170 0.3240 2.4390 2.2250 2.1960 6.4410 5.2130 5.7700 1.8560 1.6750 0.7560 1.2050 0.1720 0.6590 1.2070 0.8150 0.6520 1.4960 0.5720 0.6290 1.7780 1.6960 1.2540 1.9900 1.2830 1.3190 1.4660 0.8930 1.1950 2.2980 1.0220 1.1810 2.3100 1.5400 1.8030 4.5010 2.4670 3.4140 1.8840 1.2570 0.8910 0.8110 0.9910 1.7650 Phosphatidylinositol(18:1/18:1) 5.5430 3.7000 6.0880 7.5070 4.4610 4.9600 4.7540 4.4550 4.6760 3.6180 4.0330 6.3220 7.9150 6.4280 7.3440 11.5290 7.1110 8.1060 13.2530 12.9840 14.5660 6.9200 4.5230 6.3010 8.4840 5.8750 4.7420 6.6430 6.7400 5.8640 4.8130 5.1120 5.0020 6.4180 4.4860 5.0290 5.4160 4.6540 6.2330 5.1670 3.4330 3.7980 4.9100 4.9300 4.8960 17.1550 11.1070 14.3640 15.2430 14.3730 14.9460 8.0430 4.5160 5.6110 6.0480 9.9050 5.5060 4.9650 7.7590 5.3410 3.9180 3.7790 4.3060 7.6590 5.9620 10.7110 8.0490 10.3790 12.1680 3.7010 5.2850 2.8170 3.3310 5.5810 4.0220 8.1390 16.4360 15.5400 10.6350 16.9370 16.6130 10.8900 11.4750 11.5500 6.9120 6.5020 14.7170 5.9180 12.4420 11.8440 5.5680 5.4250 5.3000 10.8240 8.5840 11.0820 9.0330 10.1310 13.5530 3.6810 4.1030 3.8700 4.5290 4.3170 3.6070 16.0700 24.9650 25.7010 5.8490 12.3460 12.1690 9.2200 7.3480 9.1280 13.7010 15.8320 20.7510 12.5910 22.6120 18.9960 4.2180 4.9760 4.4770 6.2400 3.6850 6.1750 7.4340 6.2750 9.6780 5.5320 5.0340 4.4080 4.0620 4.1110 3.6500 10.9220 9.2570 8.8340 17.7050 15.2930 17.3690 10.7890 8.8660 9.1650 6.8280 4.5560 7.4030 4.9380 5.3160 5.1610 Phosphatidylinositol(18:1/20:3 n-6) 2.2070 2.2050 3.4820 2.5540 2.2220 2.9540 2.5190 2.1400 2.0670 2.0520 2.2740 1.8500 2.8550 2.8660 3.3030 2.4290 2.4250 2.3120 3.2780 3.2360 3.2060 2.5090 2.3130 2.7330 2.3970 2.2640 2.3390 3.3340 2.2090 3.0730 2.2300 2.3820 2.8570 2.0720 1.9160 2.3840 2.2110 2.3920 2.5920 2.1270 1.8280 2.1630 1.8610 2.8510 2.4820 2.6820 2.1250 3.2550 3.0570 3.5670 2.8190 2.2200 1.9800 2.1480 2.1000 2.0620 2.1310 2.4600 3.0870 3.3180 1.6850 1.7600 2.5030 2.6770 2.8640 2.8660 4.2380 4.1630 3.1580 1.6310 1.6570 1.2730 1.2420 1.4060 1.6860 3.2620 3.5760 3.1900 3.0240 3.3310 3.4600 2.5940 2.2500 1.8960 2.3950 3.0200 2.8540 2.4880 3.0800 3.1270 1.7530 2.3950 1.4970 2.6480 1.6550 2.8520 4.6110 4.9550 4.4390 1.3730 2.1560 1.6600 1.1220 1.3010 1.5230 3.5750 2.8900 2.8040 2.3370 2.8590 3.8730 2.2800 2.2510 2.1620 2.7050 2.9820 2.6980 2.7570 2.8730 1.0260 1.2770 2.3360 2.6090 1.9150 1.9970 2.3520 2.6550 2.8700 3.7080 1.4820 1.5110 1.5410 0.9930 1.7360 1.9680 2.5470 3.1070 3.1740 4.2740 4.4150 3.7880 2.0890 1.8780 0.6400 2.0130 1.6230 2.8630 2.3170 3.2890 3.0380 Phosphatidylinositol(18:1/20:4) 15.9000 17.1910 15.4150 14.4590 15.1240 16.9430 15.0200 18.0060 17.7790 14.8110 18.6770 18.4430 15.4220 15.9170 16.9920 13.0960 16.4520 17.7630 15.7820 18.1570 17.0760 14.0310 18.2590 17.6280 13.6010 14.5530 14.8030 17.5400 18.5360 16.0140 15.0810 14.6670 14.6460 14.1660 15.8220 14.8740 15.5680 16.0790 14.9330 14.5100 16.9690 16.3820 15.1980 15.4900 15.1920 11.1830 15.1080 11.8860 16.5130 18.8880 17.1800 10.9880 13.5860 11.7570 16.1800 12.6970 17.5250 14.3450 16.3110 13.6990 9.4300 10.4160 10.8770 15.9250 15.6490 16.3080 13.7790 13.0820 16.9670 10.3590 13.3440 10.1750 12.4150 12.3970 13.8050 15.9720 17.6530 19.3570 9.1060 11.1970 10.9840 4.1480 5.6330 3.9810 15.8860 16.2170 18.1320 14.5720 16.5450 17.1020 7.1950 8.2630 7.6640 12.1480 11.1000 11.0120 15.1000 15.7360 12.3080 9.8320 12.1360 11.8080 11.3520 10.5410 12.6600 14.8430 13.2690 13.2240 7.5940 8.8470 7.6210 5.9990 5.8920 6.9760 13.8180 13.9900 12.5840 12.5910 14.1980 11.8730 12.8880 14.4790 18.5200 13.6640 14.1010 17.3030 15.8080 16.1780 17.5170 9.9500 12.5040 14.0810 11.1090 12.5860 13.5650 13.0300 17.2260 16.9350 10.0830 13.4510 13.8620 4.6680 5.6850 4.6130 12.4790 16.3390 17.9800 14.5700 16.4670 15.3900 Phosphatidylinositol(18:1/20:5) 1.6870 1.7940 2.1940 2.2290 1.5550 2.4490 1.7270 1.8310 1.8610 1.9060 1.9220 2.3630 1.7080 1.7570 3.0290 1.6790 2.0020 1.6760 1.9930 2.4850 2.9310 1.6690 2.5750 2.1960 1.5620 1.6490 1.5570 2.2390 2.3230 1.5650 2.0620 1.5100 1.9500 1.9370 1.3560 2.1720 2.1090 1.8300 2.0760 2.0390 1.8020 2.0320 1.8410 1.1740 2.2500 1.5090 1.9950 2.4880 2.5830 2.3930 2.2130 1.6730 1.5530 1.8980 1.4250 1.7290 1.9800 1.9860 2.3390 2.1710 0.3960 0.6720 1.0950 1.4480 1.4120 1.4760 2.0580 1.2920 1.8580 1.2880 0.8290 1.2730 1.1470 1.5710 0.9780 2.0990 2.1150 1.9900 0.9640 1.6720 1.3660 0.5920 0.3190 0.7580 1.7040 2.2540 1.9030 1.1410 2.0580 1.9200 0.8090 0.5810 1.0910 1.2610 1.4260 1.1290 1.9010 2.0420 1.1200 0.6060 1.5460 2.2100 0.9390 1.4860 1.1240 1.9810 1.7430 1.7600 0.7550 0.8850 1.2140 0.2960 0.2680 0.4770 1.4230 1.6520 1.5370 1.5090 1.9280 2.0520 1.3240 1.8010 2.1900 1.3450 1.2870 2.6690 1.5680 1.7480 2.9280 1.0540 1.4240 1.7600 1.0880 1.4110 1.4050 1.8120 2.2940 2.0000 1.5060 1.8530 2.3320 0.5530 0.6090 0.6400 1.8010 1.7910 1.6770 1.0240 1.8760 2.1190 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name pubchem_id inchi_key kegg_id other_id other_id_type ri ri_type moverz_quant Phosphatidylinositol(16:0/18:1) Phosphatidylinositol(16:0/20:3 n-6) Phosphatidylinositol(16:0/20:4) Phosphatidylinositol(16:1/18:1) Phosphatidylinositol(18:0/20:3 n-6) Phosphatidylinositol(18:0/20:4) Phosphatidylinositol(18:0/22:5) Phosphatidylinositol(18:0/22:6) Phosphatidylinositol(18:1/18:1) Phosphatidylinositol(18:1/20:3 n-6) Phosphatidylinositol(18:1/20:4) Phosphatidylinositol(18:1/20:5) METABOLITES_END #END