#METABOLOMICS WORKBENCH Andre_Gollowitzer_20210401_101737_mwtab.txt DATATRACK_ID:2553 STUDY_ID:ST001741 ANALYSIS_ID:AN002834 PROJECT_ID:000000 VERSION 1 CREATED_ON April 13, 2021, 5:37 pm #PROJECT PR:PROJECT_TITLE Regulation of stress signalling by SCD1-derived phosphatidylinositols PR:PROJECT_TYPE Targeted lipidomics PR:PROJECT_SUMMARY Cytotoxic stress activates stress-activated kinases, initiates adaptive PR:PROJECT_SUMMARY mechanisms, including the unfolded protein response (UPR) and autophagy, and PR:PROJECT_SUMMARY induces programmed cell death. Fatty acid unsaturation, controlled by PR:PROJECT_SUMMARY stearoyl-CoA desaturase (SCD)1, prevents cytotoxic stress but the mechanisms are PR:PROJECT_SUMMARY diffuse. We found that 1,2-dioleoyl-sn-glycero-3-phospho-(1’-myo-inositol) PR:PROJECT_SUMMARY [PI(18:1/18:1)] is a SCD1-derived signaling lipid, which inhibits p38 PR:PROJECT_SUMMARY mitogen-activated protein kinase (MAPK) activation, counteracts UPR, autophagy PR:PROJECT_SUMMARY and apoptosis induction, and maintains cell morphology and proliferation. SCD1 PR:PROJECT_SUMMARY expression and the cellular PI(18:1/18:1) proportion decrease during the onset PR:PROJECT_SUMMARY of cell death, thereby activating stress signaling. This counter-regulation PR:PROJECT_SUMMARY applies to mechanistically diverse death-inducing conditions and occurs in PR:PROJECT_SUMMARY tissues of Scd1-defective mice. PR:INSTITUTE University of Innsbruck PR:DEPARTMENT Michael Popp Institute PR:LAST_NAME Koeberle PR:FIRST_NAME Andreas PR:ADDRESS Mitterweg 24, Innsbruck, Tyrol, 6020, Austria PR:EMAIL andreas.koeberle@uibk.ac.at PR:PHONE +43 512 507 57903 PR:FUNDING_SOURCE German Research Council (GRK 1715 and KO 4589/4-1), Phospholipid Research Center PR:FUNDING_SOURCE Heidelberg (AKO-2019-070/2-1 and AKO-2015-037/1-1), University of Jena PR:FUNDING_SOURCE (DRM/2013-05 and 2.7-05), Free State of Thuringia (41-5507-2016) and Leibniz PR:FUNDING_SOURCE ScienceCampus InfectoOptics (SAS-2015-HKI-LWC). PR:PUBLICATIONS in process #STUDY ST:STUDY_TITLE Phospholipid profiling of Scd1-defective mice ST:STUDY_TYPE Targeted lipidomics ST:STUDY_SUMMARY Mice homozygous for the Scd1ab-2J allele have a defect Scd1 gene with an ST:STUDY_SUMMARY in-frame stop codon in exon 2. To identify SCD1-derived phospholipid species, we ST:STUDY_SUMMARY analysed PI and PC species in organs and tissues that highly express SCD1 and ST:STUDY_SUMMARY are considered as targets for intervention with SCD1 inhibitors, i.e., liver, ST:STUDY_SUMMARY skin, hind leg skeletal muscle, and white abdominal fat. ST:INSTITUTE University of Innsbruck ST:DEPARTMENT Michael Popp Institute ST:LAST_NAME Koeberle ST:FIRST_NAME Andreas ST:ADDRESS Mitterweg 24, Innsbruck, Tyrol, 6020, Austria ST:EMAIL andreas.koeberle@uibk.ac.at ST:PHONE +43 512 507 57903 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 SU:GENOTYPE_STRAIN C57BL/6J SU:AGE_OR_AGE_RANGE 6 weeks SU:GENDER Male SU:ANIMAL_ANIMAL_SUPPLIER Jackson Laboratory #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#2 - 200916_SCD_1_KO_S1_WT_n1 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#3 - 200916_SCD_1_KO_S2_WT_n2 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#4 - 200916_SCD_1_KO_S2_WT_n3 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#5 - 200916_SCD_1_KO_S2_WT_n4 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#6 - 200916_SCD_1_KO_S2_WT_n5 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#7 - 200916_SCD_1_KO_S2_WT_n6 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#9 - 200916_SCD_1_KO_S7_KO_n1 Genotype:Scd1ab-2J | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#10 - 200916_SCD_1_KO_S8_KO_n2 Genotype:Scd1ab-2J | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#11 - 200916_SCD_1_KO_S9_KO_n3 Genotype:Scd1ab-2J | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#12 - 200916_SCD_1_KO_S10_KO_n4 Genotype:Scd1ab-2J | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#13 - 200916_SCD_1_KO_S11_KO_n5_repeat Genotype:Scd1ab-2J | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#16 - 200916_SCD_1_KO_M1_WT_n1 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#17 - 200916_SCD_1_KO_M2_WT_n2 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#18 - 200916_SCD_1_KO_M2_WT_n3 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#19 - 200916_SCD_1_KO_M4_WT_n4 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#20 - 200916_SCD_1_KO_M5_WT_n5 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#21 - 200916_SCD_1_KO_M6_WT_n6 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#23 - 200916_SCD_1_KO_M7_KO_n1 Genotype:Scd1ab-2J | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#24 - 200916_SCD_1_KO_M8_KO_n2 Genotype:Scd1ab-2J | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#25 - 200916_SCD_1_KO_M9_KO_n3 Genotype:Scd1ab-2J | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#26 - 200916_SCD_1_KO_M10_KO_n4 Genotype:Scd1ab-2J | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#27 - 200916_SCD_1_KO_M11_KO_n5 Genotype:Scd1ab-2J | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#30 - 200916_SCD_1_KO_L1_WT_n1 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#31 - 200916_SCD_1_KO_L2_WT_n2 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#32 - 200916_SCD_1_KO_L3_WT_n3 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#33 - 200916_SCD_1_KO_L4_WT_n4 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#34 - 200916_SCD_1_KO_L5_WT_n5 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#35 - 200916_SCD_1_KO_L6_WT_n6 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#37 - 200916_SCD_1_KO_L7_KO_n1 Genotype:Scd1ab-2J | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#38 - 200916_SCD_1_KO_L8_KO_n2 Genotype:Scd1ab-2J | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#39 - 200916_SCD_1_KO_L9_KO_n3 Genotype:Scd1ab-2J | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#40 - 200916_SCD_1_KO_L10_KO_n4 Genotype:Scd1ab-2J | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#41 - 200916_SCD_1_KO_L11_KO_n5 Genotype:Scd1ab-2J | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#44 - 200916_SCD_1_KO_F1_WT_n1 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#45 - 200916_SCD_1_KO_F2_WT_n2 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#46 - 200916_SCD_1_KO_F3_WT_n3 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#47 - 200916_SCD_1_KO_F4_WT_n4 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#48 - 200916_SCD_1_KO_F5_WT_n5 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#49 - 200916_SCD_1_KO_F6_WT_n6 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#51 - 200916_SCD_1_KO_F7_KO_n1 Genotype:Scd1ab-2J | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#52 - 200916_SCD_1_KO_F8_KO_n2 Genotype:Scd1ab-2J | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#53 - 200916_SCD_1_KO_F9_KO_n3 Genotype:Scd1ab-2J | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#54 - 200916_SCD_1_KO_F10_KO_n4 Genotype:Scd1ab-2J | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#55 - 200916_SCD_1_KO_F11_KO_n5 Genotype:Scd1ab-2J | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#2 - 200916_SCD_1_KO_S1_WT_n1 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#3 - 200916_SCD_1_KO_S2_WT_n2 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#4 - 200916_SCD_1_KO_S2_WT_n3 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#5 - 200916_SCD_1_KO_S2_WT_n4 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#6 - 200916_SCD_1_KO_S2_WT_n5 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#7 - 200916_SCD_1_KO_S2_WT_n6 Genotype:WT | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#9 - 200916_SCD_1_KO_S7_KO_n1 Genotype:Scd1ab-2J | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#10 - 200916_SCD_1_KO_S8_KO_n2 Genotype:Scd1ab-2J | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#11 - 200916_SCD_1_KO_S9_KO_n3 Genotype:Scd1ab-2J | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#12 - 200916_SCD_1_KO_S10_KO_n4 Genotype:Scd1ab-2J | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#58 - 200916_SCD_1_KO_S11_KO_n5_repeat Genotype:Scd1ab-2J | Tissue:Skin RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#16 - 200916_SCD_1_KO_M1_WT_n1 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#17 - 200916_SCD_1_KO_M2_WT_n2 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#18 - 200916_SCD_1_KO_M2_WT_n3 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#19 - 200916_SCD_1_KO_M4_WT_n4 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#20 - 200916_SCD_1_KO_M5_WT_n5 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#21 - 200916_SCD_1_KO_M6_WT_n6 Genotype:WT | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#23 - 200916_SCD_1_KO_M7_KO_n1 Genotype:Scd1ab-2J | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#24 - 200916_SCD_1_KO_M8_KO_n2 Genotype:Scd1ab-2J | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#25 - 200916_SCD_1_KO_M9_KO_n3 Genotype:Scd1ab-2J | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#26 - 200916_SCD_1_KO_M10_KO_n4 Genotype:Scd1ab-2J | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#27 - 200916_SCD_1_KO_M11_KO_n5 Genotype:Scd1ab-2J | Tissue:Skeletal muscle RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#30 - 200916_SCD_1_KO_L1_WT_n1 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#31 - 200916_SCD_1_KO_L2_WT_n2 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#32 - 200916_SCD_1_KO_L3_WT_n3 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#33 - 200916_SCD_1_KO_L4_WT_n4 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#34 - 200916_SCD_1_KO_L5_WT_n5 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#35 - 200916_SCD_1_KO_L6_WT_n6 Genotype:WT | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#37 - 200916_SCD_1_KO_L7_KO_n1 Genotype:Scd1ab-2J | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#38 - 200916_SCD_1_KO_L8_KO_n2 Genotype:Scd1ab-2J | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#39 - 200916_SCD_1_KO_L9_KO_n3 Genotype:Scd1ab-2J | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#40 - 200916_SCD_1_KO_L10_KO_n4 Genotype:Scd1ab-2J | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#41 - 200916_SCD_1_KO_L11_KO_n5 Genotype:Scd1ab-2J | Tissue:Liver RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#44 - 200916_SCD_1_KO_F1_WT_n1 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#45 - 200916_SCD_1_KO_F2_WT_n2 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#46 - 200916_SCD_1_KO_F3_WT_n3 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#47 - 200916_SCD_1_KO_F4_WT_n4 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#48 - 200916_SCD_1_KO_F5_WT_n5 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#49 - 200916_SCD_1_KO_F6_WT_n6 Genotype:WT | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#51 - 200916_SCD_1_KO_F7_KO_n1 Genotype:Scd1ab-2J | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#52 - 200916_SCD_1_KO_F8_KO_n2 Genotype:Scd1ab-2J | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#53 - 200916_SCD_1_KO_F9_KO_n3 Genotype:Scd1ab-2J | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#54 - 200916_SCD_1_KO_F10_KO_n4 Genotype:Scd1ab-2J | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF SUBJECT_SAMPLE_FACTORS - 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#55 - 200916_SCD_1_KO_F11_KO_n5 Genotype:Scd1ab-2J | Tissue:Fat RAW_FILE_NAME=200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF #COLLECTION CO:COLLECTION_SUMMARY Mouse tissues were homogenized in PBS pH 7.4 for lipid extraction and UPLC-MS/MS CO:COLLECTION_SUMMARY analysis CO:SAMPLE_TYPE Tissue CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY Tissues from 6-week old male C57BL/6J mice (wildtype or homozygous for the TR:TREATMENT_SUMMARY Scd1ab-2J allele) were purchased from Jackson Laboratory. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Phospholipids were extracted from tissue homogenates by successive addition of SP:SAMPLEPREP_SUMMARY PBS pH 7.4, methanol, chloroform, and saline to a final ratio of 14:34:35:17. SP:SAMPLEPREP_SUMMARY Evaporation of the organic layer yielded a lipid film that was dissolved in SP:SAMPLEPREP_SUMMARY methanol and subjected to UPLC-MS/MS. SP:EXTRACT_STORAGE -20℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Chromatographic separation of phospholipids was carried out on an Acquity BEH C8 CH:CHROMATOGRAPHY_SUMMARY column (1.7 μm, 2.1×100 mm, Waters, Milford, MA) using an ExionLC UHPLC. CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME ExionLC CH:COLUMN_NAME Waters Acquity BEH C8 (100 x 2.1mm, 1.7um) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME ABI Sciex Qtrap6500+ MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS Targeted MRM with pre-optimized settings and subsequent automated integration of MS:MS_COMMENTS selected signals using Analyst 1.7 (Sciex). #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS relative intensities MS_METABOLITE_DATA_START Samples 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#2 - 200916_SCD_1_KO_S1_WT_n1 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#3 - 200916_SCD_1_KO_S2_WT_n2 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#4 - 200916_SCD_1_KO_S2_WT_n3 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#5 - 200916_SCD_1_KO_S2_WT_n4 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#6 - 200916_SCD_1_KO_S2_WT_n5 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#7 - 200916_SCD_1_KO_S2_WT_n6 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#9 - 200916_SCD_1_KO_S7_KO_n1 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#10 - 200916_SCD_1_KO_S8_KO_n2 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#11 - 200916_SCD_1_KO_S9_KO_n3 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#12 - 200916_SCD_1_KO_S10_KO_n4 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#13 - 200916_SCD_1_KO_S11_KO_n5_repeat 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#16 - 200916_SCD_1_KO_M1_WT_n1 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#17 - 200916_SCD_1_KO_M2_WT_n2 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#18 - 200916_SCD_1_KO_M2_WT_n3 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#19 - 200916_SCD_1_KO_M4_WT_n4 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#20 - 200916_SCD_1_KO_M5_WT_n5 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#21 - 200916_SCD_1_KO_M6_WT_n6 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#23 - 200916_SCD_1_KO_M7_KO_n1 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#24 - 200916_SCD_1_KO_M8_KO_n2 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#25 - 200916_SCD_1_KO_M9_KO_n3 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#26 - 200916_SCD_1_KO_M10_KO_n4 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#27 - 200916_SCD_1_KO_M11_KO_n5 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#30 - 200916_SCD_1_KO_L1_WT_n1 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#31 - 200916_SCD_1_KO_L2_WT_n2 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#32 - 200916_SCD_1_KO_L3_WT_n3 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#33 - 200916_SCD_1_KO_L4_WT_n4 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#34 - 200916_SCD_1_KO_L5_WT_n5 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#35 - 200916_SCD_1_KO_L6_WT_n6 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#37 - 200916_SCD_1_KO_L7_KO_n1 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#38 - 200916_SCD_1_KO_L8_KO_n2 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#39 - 200916_SCD_1_KO_L9_KO_n3 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#40 - 200916_SCD_1_KO_L10_KO_n4 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#41 - 200916_SCD_1_KO_L11_KO_n5 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#44 - 200916_SCD_1_KO_F1_WT_n1 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#45 - 200916_SCD_1_KO_F2_WT_n2 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#46 - 200916_SCD_1_KO_F3_WT_n3 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#47 - 200916_SCD_1_KO_F4_WT_n4 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#48 - 200916_SCD_1_KO_F5_WT_n5 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#49 - 200916_SCD_1_KO_F6_WT_n6 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#51 - 200916_SCD_1_KO_F7_KO_n1 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#52 - 200916_SCD_1_KO_F8_KO_n2 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#53 - 200916_SCD_1_KO_F9_KO_n3 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#54 - 200916_SCD_1_KO_F10_KO_n4 200916_SCD_1_KO_in_vivo_PI_dil_1_20_L_dil_1_10_SMF_#55 - 200916_SCD_1_KO_F11_KO_n5 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#2 - 200916_SCD_1_KO_S1_WT_n1 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#3 - 200916_SCD_1_KO_S2_WT_n2 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#4 - 200916_SCD_1_KO_S2_WT_n3 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#5 - 200916_SCD_1_KO_S2_WT_n4 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#6 - 200916_SCD_1_KO_S2_WT_n5 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#7 - 200916_SCD_1_KO_S2_WT_n6 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#9 - 200916_SCD_1_KO_S7_KO_n1 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#10 - 200916_SCD_1_KO_S8_KO_n2 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#11 - 200916_SCD_1_KO_S9_KO_n3 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#12 - 200916_SCD_1_KO_S10_KO_n4 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#58 - 200916_SCD_1_KO_S11_KO_n5_repeat 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#16 - 200916_SCD_1_KO_M1_WT_n1 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#17 - 200916_SCD_1_KO_M2_WT_n2 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#18 - 200916_SCD_1_KO_M2_WT_n3 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#19 - 200916_SCD_1_KO_M4_WT_n4 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#20 - 200916_SCD_1_KO_M5_WT_n5 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#21 - 200916_SCD_1_KO_M6_WT_n6 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#23 - 200916_SCD_1_KO_M7_KO_n1 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#24 - 200916_SCD_1_KO_M8_KO_n2 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#25 - 200916_SCD_1_KO_M9_KO_n3 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#26 - 200916_SCD_1_KO_M10_KO_n4 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#27 - 200916_SCD_1_KO_M11_KO_n5 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#30 - 200916_SCD_1_KO_L1_WT_n1 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#31 - 200916_SCD_1_KO_L2_WT_n2 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#32 - 200916_SCD_1_KO_L3_WT_n3 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#33 - 200916_SCD_1_KO_L4_WT_n4 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#34 - 200916_SCD_1_KO_L5_WT_n5 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#35 - 200916_SCD_1_KO_L6_WT_n6 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#37 - 200916_SCD_1_KO_L7_KO_n1 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#38 - 200916_SCD_1_KO_L8_KO_n2 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#39 - 200916_SCD_1_KO_L9_KO_n3 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#40 - 200916_SCD_1_KO_L10_KO_n4 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#41 - 200916_SCD_1_KO_L11_KO_n5 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#44 - 200916_SCD_1_KO_F1_WT_n1 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#45 - 200916_SCD_1_KO_F2_WT_n2 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#46 - 200916_SCD_1_KO_F3_WT_n3 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#47 - 200916_SCD_1_KO_F4_WT_n4 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#48 - 200916_SCD_1_KO_F5_WT_n5 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#49 - 200916_SCD_1_KO_F6_WT_n6 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#51 - 200916_SCD_1_KO_F7_KO_n1 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#52 - 200916_SCD_1_KO_F8_KO_n2 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#53 - 200916_SCD_1_KO_F9_KO_n3 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#54 - 200916_SCD_1_KO_F10_KO_n4 200916_SCD_1_KO_in_vivo_PC_dil_1_20_SMLF_#55 - 200916_SCD_1_KO_F11_KO_n5 Factors Genotype:WT | Tissue:Skin Genotype:WT | Tissue:Skin Genotype:WT | Tissue:Skin Genotype:WT | Tissue:Skin Genotype:WT | Tissue:Skin Genotype:WT | Tissue:Skin Genotype:Scd1ab-2J | Tissue:Skin Genotype:Scd1ab-2J | Tissue:Skin Genotype:Scd1ab-2J | Tissue:Skin Genotype:Scd1ab-2J | Tissue:Skin Genotype:Scd1ab-2J | Tissue:Skin Genotype:WT | Tissue:Skeletal muscle Genotype:WT | Tissue:Skeletal muscle Genotype:WT | Tissue:Skeletal muscle Genotype:WT | Tissue:Skeletal muscle Genotype:WT | Tissue:Skeletal muscle Genotype:WT | Tissue:Skeletal muscle Genotype:Scd1ab-2J | Tissue:Skeletal muscle Genotype:Scd1ab-2J | Tissue:Skeletal muscle Genotype:Scd1ab-2J | Tissue:Skeletal muscle Genotype:Scd1ab-2J | Tissue:Skeletal muscle Genotype:Scd1ab-2J | Tissue:Skeletal muscle Genotype:WT | Tissue:Liver Genotype:WT | Tissue:Liver Genotype:WT | Tissue:Liver Genotype:WT | Tissue:Liver Genotype:WT | Tissue:Liver Genotype:WT | Tissue:Liver Genotype:Scd1ab-2J | Tissue:Liver Genotype:Scd1ab-2J | Tissue:Liver Genotype:Scd1ab-2J | Tissue:Liver Genotype:Scd1ab-2J | Tissue:Liver Genotype:Scd1ab-2J | Tissue:Liver Genotype:WT | Tissue:Fat Genotype:WT | Tissue:Fat Genotype:WT | Tissue:Fat Genotype:WT | Tissue:Fat Genotype:WT | Tissue:Fat Genotype:WT | Tissue:Fat Genotype:Scd1ab-2J | Tissue:Fat Genotype:Scd1ab-2J | Tissue:Fat Genotype:Scd1ab-2J | Tissue:Fat Genotype:Scd1ab-2J | Tissue:Fat Genotype:Scd1ab-2J | Tissue:Fat Genotype:WT | Tissue:Skin Genotype:WT | Tissue:Skin Genotype:WT | Tissue:Skin Genotype:WT | Tissue:Skin Genotype:WT | Tissue:Skin Genotype:WT | Tissue:Skin Genotype:Scd1ab-2J | Tissue:Skin Genotype:Scd1ab-2J | Tissue:Skin Genotype:Scd1ab-2J | Tissue:Skin Genotype:Scd1ab-2J | Tissue:Skin Genotype:Scd1ab-2J | Tissue:Skin Genotype:WT | Tissue:Skeletal muscle Genotype:WT | Tissue:Skeletal muscle Genotype:WT | Tissue:Skeletal muscle Genotype:WT | Tissue:Skeletal muscle Genotype:WT | Tissue:Skeletal muscle Genotype:WT | Tissue:Skeletal muscle Genotype:Scd1ab-2J | Tissue:Skeletal muscle Genotype:Scd1ab-2J | Tissue:Skeletal muscle Genotype:Scd1ab-2J | Tissue:Skeletal muscle Genotype:Scd1ab-2J | Tissue:Skeletal muscle Genotype:Scd1ab-2J | Tissue:Skeletal muscle Genotype:WT | Tissue:Liver Genotype:WT | Tissue:Liver Genotype:WT | Tissue:Liver Genotype:WT | Tissue:Liver Genotype:WT | Tissue:Liver Genotype:WT | Tissue:Liver Genotype:Scd1ab-2J | Tissue:Liver Genotype:Scd1ab-2J | Tissue:Liver Genotype:Scd1ab-2J | Tissue:Liver Genotype:Scd1ab-2J | Tissue:Liver Genotype:Scd1ab-2J | Tissue:Liver Genotype:WT | Tissue:Fat Genotype:WT | Tissue:Fat Genotype:WT | Tissue:Fat Genotype:WT | Tissue:Fat Genotype:WT | Tissue:Fat Genotype:WT | Tissue:Fat Genotype:Scd1ab-2J | Tissue:Fat Genotype:Scd1ab-2J | Tissue:Fat Genotype:Scd1ab-2J | Tissue:Fat Genotype:Scd1ab-2J | Tissue:Fat Genotype:Scd1ab-2J | Tissue:Fat Phosphatidylinositol(16:0/16:0) 0.589 0.502 0.685 0.919 0.773 0.754 0.771 1.004 0.603 1.299 1.447 0.988 1.249 0.406 1.18 1.322 1.16 0.312 0.651 1.662 1.005 0.543 0.031 0.036 0.046 0.026 0.045 0.044 0.025 0.043 0.083 0.03 0.031 1.372 0.408 0.192 0 0.05 0.094 0.046 0.02 0.045 0.075 0.109 Phosphatidylinositol(16:0/18:1) 2.643 2.214 2.338 2.895 2.985 2.436 1.756 2.31 1.848 2.254 2.384 1.831 1.978 1.053 1.929 2.022 1.771 0.376 0.484 2.053 1.284 0.765 0.387 0.302 0.409 0.335 0.308 0.19 0.081 0.1 0.146 0.091 0.065 4.16 0.081 0.439 0.384 0.398 0.094 0.221 0.263 0.146 0.236 0.244 Phosphatidylinositol(16:0/18:2) 2.036 1.495 1.663 1.902 1.834 1.719 5.333 4.597 3.862 5.441 5.287 0.622 0.727 0.606 0.614 0.697 0.681 0.635 1.038 1.756 1.786 1.278 2.019 2.045 2.376 1.763 1.52 1.622 3.17 3.886 3.288 2.87 2.655 1.658 0.736 1.484 1.329 0.994 1.358 0.822 0.792 0.959 0.989 0.624 Phosphatidylinositol(16:1/18:1) 1.068 0.865 0.792 1.098 1.189 0.914 0.052 0.13 0.051 0.053 0.118 0.218 0.256 0.222 0.186 0.183 0.187 0.018 0.031 0.119 0.091 0.049 0.087 0.093 0.095 0.093 0.07 0.038 0.004 0.002 0 0 0 0.976 0.246 0.055 0.177 0.1 0 0 0 0.023 0.021 0 Phosphatidylinositol(18:0/18:1) 7.633 7.489 7.429 7.205 9.12 7.737 2.864 3.646 3.64 2.927 3.448 0.61 1.273 0.649 0.821 0.919 0.592 0.324 0.371 1.001 0.812 0.755 0.191 0.231 0.223 0.2 0.187 0.155 0.087 0.07 0.205 0.052 0.048 4.784 0.817 0.247 0.59 0.298 0.234 0.301 0.284 0.135 0.247 0.434 Phosphatidylinositol(18:1/18:1) 4.348 2.967 3.589 4.453 4.518 3.633 0.902 1.83 1.068 1.058 1.544 0.548 0.69 0.604 0.615 0.731 0.51 0.127 0.159 0.597 0.281 0.257 0.464 0.377 0.363 0.328 0.317 0.209 0.019 0.016 0.045 0 0.012 4.336 0.979 1.102 1.651 1.094 1.172 0.093 0.182 0.225 0.118 0.136 Phosphatidylinositol(18:0/18:2) 6.473 6.207 6.511 6.417 6.627 6.809 13.461 13.551 11.353 12.968 12.73 3.47 4.378 2.615 3.701 3.616 2.989 5.434 7.256 12.347 10.817 7.731 2.467 3.278 3.044 2.443 2.168 2.427 4.814 4.029 4.566 3.288 3.162 2.282 1.469 2.613 1.388 2.39 2.111 3.561 2.712 4.465 4.009 3.582 Phosphatidylinositol(16:0/20:3 n-6) 0.3 0.428 0.394 0.445 0.367 0.342 0.675 0.752 0.708 0.906 0.943 0.335 0.317 0.534 0.355 0.397 0.337 0.281 0.353 0.621 0.562 0.538 1.659 1.294 1.575 1.437 1.579 1.179 1.037 1.344 1.126 1.211 0.999 0.376 0.082 0.192 0.177 0.497 0.421 0.267 0.506 0.225 0.225 0.163 Phosphatidylinositol(16:0/20:3 n-9) 0.098 0.105 0.09 0.138 0.09 0.093 0.056 0.096 0.028 0.101 0.083 0.065 0.061 0.078 0.045 0.082 0.066 0.004 0.03 0.143 0.04 0.054 0.363 0.183 0.191 0.231 0.436 0.197 0.044 0.059 0.045 0.052 0.023 0.575 0.327 0.219 0.354 0.597 0.374 0.035 0 0.101 0.097 0.027 Phosphatidylinositol(18:1/18:2) 2.062 1.457 1.613 2.162 1.855 1.607 1.472 1.666 1.408 1.503 1.633 0.572 0.629 0.593 0.622 0.654 0.547 0.384 0.58 1.563 1.304 0.922 1.344 1.222 1.184 1.031 1.08 1.116 0.428 0.27 0.346 0.191 0.19 1.482 2.285 2.058 3.098 1.591 2.484 0.776 0.324 0.619 0.43 0.353 Phosphatidylinositol(16:0/20:4) 5.292 4.924 4.87 5.575 4.819 4.674 6.585 4.759 5.711 6.024 5.306 2.862 3.329 3.208 2.653 3.089 2.943 1.523 1.929 2.342 2.369 2.589 9.353 7.988 9.354 8.272 9.13 7.211 5.196 6.392 6.458 5.55 4.683 14.895 14.2 16.026 16.027 16.815 13.396 5.225 5.572 5.707 5.976 4.698 Phosphatidylinositol(18:0/20:4) 52.936 56.05 54.559 52.383 52.266 55.851 54.776 49.536 55.376 51.38 50.139 67.539 63.529 67.62 66.97 66.009 67.695 64.516 63.827 49.787 55.851 58.48 67.205 70.475 69.298 71.371 68.018 72.912 74.602 74.081 72.551 77.004 79.701 47.209 60.422 59.406 53.789 56.115 59.669 80.668 81.888 80.932 80.029 82.053 Phosphatidylinositol(18:0/20:3 n-6) 3.399 3.985 4.016 3.563 3.258 3.214 3.147 5.492 5.318 4.708 5.529 6.54 6.296 7.209 6.065 6.409 6.302 6.496 6.589 12.596 8.465 10.465 5.343 5.375 4.94 4.969 5.619 4.954 5.599 5.589 5.883 5.634 5.052 1.262 1.06 1.102 1.182 0.796 1.03 2.109 2.269 1.339 1.9 1.98 Phosphatidylinositol(18:0/20:3 n-9) 0.809 0.973 1.066 0.853 1.065 0.956 0.394 0.685 0.626 0.507 0.705 1.074 1.11 1.23 1.02 1.082 1.115 0.236 0.256 0.562 0.582 0.513 1.95 1.522 1.161 1.74 2.2 1.437 0.29 0.262 0.357 0.429 0.328 0.866 1.06 0.577 0.914 1.045 1.358 0.465 0.527 0.429 0.42 0.678 Phosphatidylinositol(18:1/20:3 n-6) 0.3 0.288 0.374 0.296 0.311 0.332 0.138 0.365 0.208 0.255 0.258 0.434 0.317 0.67 0.314 0.467 0.388 0.19 0.194 0.538 0.393 0.379 0.594 0.519 0.521 0.496 0.631 0.518 0.114 0.07 0.069 0.05 0.052 0.421 0.408 0.494 0.56 0.298 0.75 0.151 0.183 0.146 0.129 0.217 Phosphatidylinositol(18:1/20:3 n-9) 0.035 0.087 0.062 0.046 0.099 0.064 0.018 0.065 0.047 0.025 0.071 0.061 0.051 0.099 0.041 0.079 0.076 0.004 0.014 0 0.05 0.025 0.156 0.063 0.067 0.107 0.166 0.096 0.008 0.008 0 0 0.003 0.111 0 0.137 0.354 0.497 0.749 0.035 0 0.034 0.064 0.054 Phosphatidylinositol(18:1/20:4) 4.463 4.081 4.051 4.487 3.815 3.559 1.822 1.941 2.065 2.013 1.784 3.251 3.482 4.242 3.059 3.312 3.367 0.955 1.098 1.455 2.049 2.144 4.818 3.564 3.698 3.769 4.977 4.311 0.839 0.476 0.73 0.373 0.36 9.025 14.93 12.748 17.2 15.678 13.629 4.111 2.853 3.096 2.921 2.556 Phosphatidylinositol(18:0/22:5 n-3) 0.993 1.243 1.188 1.082 0.892 1.018 1.66 2.515 2.025 2.132 2.148 2.688 3.153 2.633 3.302 2.698 2.91 6.635 6.549 5.091 5.181 5.143 0.272 0.279 0.264 0.343 0.236 0.253 0.526 0.678 1.301 0.874 0.706 0.221 0.163 0.385 0.295 0.15 0.327 0.499 0.608 0.765 1.096 0.842 Phosphatidylinositol(18:0/22:4) 2.004 2.483 2.455 2.076 2.26 2.199 1.266 1.205 1.411 1.339 1.043 1.24 1.658 1.405 1.318 1.437 1.181 0.528 0.899 1.479 1.254 1.105 0.392 0.298 0.244 0.294 0.412 0.305 0.199 0.231 0.298 0.203 0.196 0.332 0.246 0.302 0.324 0.348 0.562 0.174 0.284 0.203 0.15 0.407 Phosphatidylinositol(18:1/22:4) 0.398 0.296 0.315 0.352 0.316 0.38 0.065 0.049 0.072 0.05 0.083 0.137 0.118 0.172 0.151 0.151 0.162 0.013 0.019 0.012 0.03 0.039 0.044 0.034 0.018 0.038 0.04 0.026 0.01 0.003 0.024 0.006 0.003 0.178 0 0.055 0.088 0.249 0.094 0.023 0 0.022 0 0.027 Phosphatidylinositol(18:0/22:6) 2.119 1.861 1.939 1.653 1.542 1.712 2.787 3.802 2.572 3.058 3.318 4.914 5.397 4.153 5.041 4.642 5.021 11.011 7.673 4.276 5.793 6.228 0.86 0.822 0.93 0.715 0.862 0.799 2.908 2.39 2.479 2.093 1.731 3.478 0.082 0.165 0.118 0 0.094 0.419 0.732 0.384 0.868 0.814 1-palmitoyl-2-linoleoylphosphatidylcholine(14:0/16:0) 0.609 0.554 0.714 0.815 0.702 0.681 0.888 0.934 0.98 0.981 0.984 0.678 0.708 0.553 0.816 0.693 0.758 0.887 0.826 0.86 0.675 0.651 0.036 0.036 0.047 0.052 0.043 0.042 0.059 0.06 0.127 0.054 0.046 0.328 0.183 0.11 0.171 0.085 0.148 0.063 0.073 0.086 0.146 0.125 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/16:0) 21.405 18.816 20.048 22.224 22.84 23.43 17.989 18.79 20.687 20.693 19.407 7.021 9.109 5.89 7.628 7.04 6.776 7.079 7.633 11.345 10.909 9.247 2.239 2.11 2.512 2.261 2.187 2.62 2.719 2.331 2.994 1.836 1.968 8.826 7.305 8.558 7.319 7.114 6.621 2.123 3.001 4.038 5.091 4.639 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/16:1) 1.539 1.626 1.737 1.6 1.715 1.519 0.997 1.345 0.891 1.055 1.228 3.055 2.876 3.558 3.377 3.436 3.247 0.886 0.82 1.093 0.948 1.001 1.592 1.364 1.687 1.828 1.614 1.191 0.153 0.168 0.224 0.18 0.143 1.925 1.338 1.505 1.566 1.607 1.116 0.098 0.128 0.184 0.17 0.118 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/18:1) 13.76 12.711 14.827 14.592 14.622 13.512 8.473 10.303 8.949 9.633 10.655 14.754 16.409 16.652 15.836 16.171 15.602 10.423 9.802 13.304 11.182 10.735 17.382 15.835 16.552 16.88 17.978 14.823 4.939 5.711 6.586 6.369 6.082 13.125 7.775 7.111 6.707 8.545 6.574 2.425 3.13 3.774 3.83 3.266 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/18:2) 10.911 11.423 11.374 12.185 10.396 10.837 18.838 17.311 17.513 18.664 17.901 15.689 14.804 24.068 15.042 16.996 14.901 24.922 25.167 28.957 28.127 29.288 18.638 19.828 19.834 17.944 17.308 18.997 26.811 29.675 29.314 30.55 31.505 7.988 14.014 14.865 14.571 14.213 13.52 12.568 12.851 15.128 14.619 13.089 1-palmitoyl-2-linoleoylphosphatidylcholine(16:1/18:1) 0.581 0.548 0.551 0.655 0.633 0.572 0.159 0.356 0.147 0.21 0.305 0.697 0.663 0.722 0.799 0.761 0.693 0.104 0.11 0.162 0.123 0.152 0.94 0.702 0.782 1.005 0.955 0.725 0.038 0.034 0.046 0.034 0.043 0.959 0.461 0.337 0.415 0.571 0.35 0.039 0.025 0.036 0.021 0.013 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/18:1) 11.83 11.808 12.136 10.962 12.662 11.318 10.216 11.131 10.49 10.523 10.307 4.929 5.654 4.185 5.485 5.325 4.435 3.941 4.271 6.75 6.297 5.534 6.84 7.065 7.378 7.692 8.247 6.218 4.034 3.482 4.228 3.417 3.745 27.866 11.55 12.844 12.111 14.132 11.911 9.183 9.466 10.215 9.914 9.566 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/18:1) 6.357 5.861 6.248 5.889 6.375 5.866 1.264 2.773 1.461 1.77 2.413 1.928 2.125 1.559 2.049 1.987 1.846 0.68 0.652 1.117 0.926 0.932 2.613 1.702 1.716 1.948 2.746 1.758 0.172 0.145 0.268 0.112 0.147 6.868 3.858 3.054 3.349 3.884 3.004 0.737 0.745 0.792 0.711 0.607 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/18:2) 9.209 9.067 8.677 10.306 8.779 8.901 23.493 20.953 21.78 20.183 20.157 5.763 5.085 3.884 5.461 5.931 5.133 9.012 10.48 16.27 15.651 12.97 11.952 14.147 12.624 12.939 12.07 12.825 25.053 24.419 25.093 24.177 22.417 14.815 28.495 32.454 31.604 27.545 34.928 63.813 60.898 53.272 51.973 56.661 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/20:3) 0.885 1.064 1.059 0.88 0.949 0.866 0.738 0.79 0.871 0.808 0.851 2.609 2.068 3.675 2.695 2.625 2.664 1.908 1.877 1.392 1.268 1.723 3.462 2.67 3.36 3.507 3.019 3.275 2.762 2.679 1.862 2.517 2.452 0.684 0.973 0.814 0.923 0.892 0.611 0.245 0.351 0.415 0.523 0.39 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/18:2) 3.962 3.986 3.661 3.239 3.701 3.645 3.473 3.578 2.978 3.369 3.319 2.223 1.773 2.1 1.978 1.965 1.867 1.692 1.944 2.387 2.14 2.66 4.771 3.397 3.696 3.863 4.693 4.048 2.066 1.364 1.185 0.967 1.279 2.928 6.544 4.9 6.207 5.738 7.079 2.893 1.878 2.515 2.158 1.947 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/20:4) 7.089 8.89 7.555 6.698 6.15 7.121 3.494 2.963 3.45 3.308 3.239 18.549 16.931 17.851 16.303 16.426 19.198 10.251 10.2 4.634 6.642 7.553 8.749 9.491 9.262 8.563 8.808 10.392 6.525 6.066 6.121 6.512 6.281 3.259 4.228 3.306 3.317 3.354 3.136 0.711 1.069 1.587 1.772 1.344 1-palmitoyl-2-linoleoylphosphatidylcholine(16:1/20:4) 0.207 0.269 0.227 0.213 0.201 0.227 0.047 0.033 0.038 0.041 0.042 0.715 0.552 0.743 0.766 0.64 0.71 0.088 0.078 0.035 0.046 0.077 0.438 0.331 0.423 0.445 0.407 0.457 0.042 0.031 0.027 0.032 0.035 0.138 0.109 0.092 0.093 0.097 0.059 0.004 0.01 0.018 0.012 0.013 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/22:4) 0.934 0.906 0.792 0.64 0.78 0.883 0.302 0.247 0.266 0.276 0.225 0.999 1.198 1.047 1.066 1.01 1.062 0.31 0.505 0.346 0.415 0.477 0.141 0.109 0.132 0.124 0.123 0.124 0.035 0.032 0.059 0.044 0.04 0.188 0.097 0.221 0.114 0.212 0.279 0.014 0.061 0.072 0.09 0.069 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/20:3) 1.047 1.303 1.074 1.055 1.131 1.139 1.554 1.456 1.991 1.551 1.651 1.183 1.115 0.707 1.182 1.214 1.112 0.931 1.228 1.445 1.343 1.407 3.379 3.482 3.298 3.954 3.51 3.577 4.882 4.142 2.998 3.806 3.97 1.468 2.276 2.397 2.488 2.98 2.25 1.404 1.862 2.013 2.463 2.357 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/20:4) 4.881 5.592 4.703 4.123 4.326 4.917 4.328 3.085 4.071 3.539 3.47 6.705 6.035 3.298 6.09 6.06 6.595 3.637 5.051 3.279 4.231 4.456 6.847 8.558 7.034 7.313 6.837 8.66 7.524 7.031 6.541 6.811 6.555 5.692 6.998 5.268 6.08 5.947 6.065 2.198 2.913 3.805 4.311 3.965 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/20:3) 0.22 0.272 0.266 0.263 0.285 0.245 0.119 0.142 0.131 0.14 0.151 0.242 0.195 0.283 0.218 0.242 0.236 0.086 0.093 0.066 0.095 0.103 0.788 0.468 0.529 0.654 0.751 0.639 0.195 0.128 0.086 0.099 0.101 0.237 0.413 0.271 0.382 0.412 0.385 0.062 0.039 0.04 0.052 0.052 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/20:4) 1.528 1.804 1.446 1.005 1.334 1.484 0.487 0.432 0.426 0.45 0.452 1.905 1.724 1.398 1.836 1.747 1.838 0.565 0.542 0.321 0.403 0.558 2.918 2.161 2.259 2.338 2.858 2.901 0.71 0.48 0.385 0.319 0.457 1.236 1.508 0.829 1.298 1.322 1.11 0.119 0.14 0.22 0.225 0.193 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/22:5) 0.455 0.523 0.486 0.481 0.356 0.449 0.485 0.634 0.548 0.572 0.637 1.996 1.942 1.983 2.462 2.069 2.327 4.327 3.9 1.393 1.742 2.596 0.343 0.286 0.358 0.387 0.277 0.271 0.305 0.558 0.696 0.635 0.667 0.081 0.219 0.107 0.15 0.121 0.101 0.108 0.13 0.248 0.278 0.236 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/22:6) 1.064 1.187 1.041 0.962 0.809 0.982 1.133 1.39 0.93 0.926 1.292 6.068 6.192 4.662 6.377 5.598 6.79 14.205 10.966 2.793 4.177 5.358 3.945 4.102 4.587 4.166 3.622 4.368 7.326 7.57 6.335 7.372 7.879 0.355 0.535 0.283 0.39 0.28 0.189 0.323 0.303 0.441 0.499 0.344 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/22:5) 0.157 0.146 0.161 0.104 0.116 0.119 0.291 0.309 0.346 0.314 0.334 0.349 0.41 0.174 0.394 0.349 0.351 0.82 0.904 0.52 0.578 0.623 0.115 0.146 0.143 0.154 0.116 0.116 0.149 0.264 0.545 0.39 0.365 0.061 0.11 0.073 0.089 0.103 0.065 0.137 0.16 0.196 0.248 0.223 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/22:4) 0.733 0.902 0.645 0.58 0.661 0.756 0.446 0.287 0.422 0.378 0.286 0.523 0.724 0.278 0.583 0.499 0.517 0.194 0.343 0.285 0.313 0.396 0.158 0.156 0.17 0.171 0.168 0.153 0.078 0.081 0.14 0.109 0.101 0.261 0.146 0.239 0.139 0.157 0.171 0.043 0.079 0.147 0.125 0.138 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/22:4) 0.187 0.212 0.165 0.169 0.186 0.15 0.034 0.022 0.034 0.028 0.018 0.075 0.104 0.056 0.09 0.063 0.065 0.015 0.023 0.014 0.021 0.03 0.029 0.019 0.02 0.026 0.034 0.023 0.002 0.002 0.003 0.005 0.003 0.047 0.024 0.029 0.061 0.061 0.012 0.003 0.005 0.019 0.006 0.01 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/22:6) 0.268 0.332 0.25 0.262 0.18 0.242 0.656 0.6 0.504 0.488 0.572 0.889 1.146 0.411 0.994 0.793 0.888 2.568 2.25 1.09 1.549 1.252 0.983 1.254 1.062 1.155 0.961 1.131 2.966 3.156 3.795 3.331 3.333 0.529 0.571 0.283 0.366 0.399 0.232 0.638 0.64 0.684 0.704 0.567 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/22:5) 0.064 0.053 0.052 0.066 0.035 0.033 0.03 0.048 0.045 0.046 0.033 0.103 0.097 0.062 0.116 0.084 0.1 0.111 0.086 0.03 0.069 0.081 0.059 0.037 0.038 0.047 0.046 0.043 0.015 0.018 0.018 0.013 0.017 0.026 0.098 0.007 0.024 0.036 0.006 0.018 0.015 0.014 0.014 0.029 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/22:6) 0.117 0.148 0.105 0.033 0.075 0.105 0.063 0.088 0.052 0.054 0.069 0.351 0.362 0.202 0.355 0.278 0.291 0.357 0.249 0.112 0.13 0.141 0.641 0.545 0.498 0.582 0.622 0.622 0.439 0.373 0.324 0.311 0.369 0.109 0.17 0.044 0.065 0.194 0.077 0.031 0.027 0.038 0.044 0.036 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Standardized name Formula Exact mass Super class Main class Sub class Phosphatidylinositol(16:0/16:0) PI 16:0/16:0 C41H79O13P 810.5258 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(16:0/18:1) PI 16:0/18:1 C43H81O13P 836.5415 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(16:1/18:1) PI 16:1/18:1 C43H79O13P 834.5258 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:0/18:1) PI 18:0/18:1 C45H85O13P 864.5728 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:1/18:1) PI 18:1/18:1 C45H83O13P 862.5571 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(16:0/18:2) PI 16:0/18:2 C43H79O13P 834.5258 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:0/18:2) PI 18:0/18:2 C45H83O13P 862.5571 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:1/18:2) PI 18:1/18:2 C45H81O13P 860.5415 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(16:0/20:3 n-6) - C45H81O13P 860.5415 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(16:0/20:3 n-9) - C45H81O13P 860.5415 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:0/20:3 n-6) - C47H85O13P 888.5728 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:0/20:3 n-9) - C47H85O13P 888.5728 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:1/20:3 n-6) - C47H83O13P 886.5571 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:1/20:3 n-9) - C47H83O13P 886.5571 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(16:0/20:4) PI 16:0/20:4 C45H79O13P 858.5258 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:0/20:4) PI 18:0/20:4 C47H83O13P 886.5571 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:1/20:4) PI 18:1/20:4 C47H81O13P 884.5415 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:0/22:4) PI 18:0/22:4 C49H87O13P 914.5884 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:1/22:4) PI 18:1/22:4 C49H85O13P 912.5728 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:0/22:5 n-3) - C49H85O13P 912.5728 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol Phosphatidylinositol(18:0/22:6) PI 18:0/22:6 C49H83O13P 910.5571 Glycerophospholipids Glycerophosphoinositols Phosphatidylinositol 1-palmitoyl-2-linoleoylphosphatidylcholine(14:0/16:0) PC 14:0/16:0 C38H76NO8P 705.5309 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/16:0) PC 16:0/16:0 C40H80NO8P 733.5622 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/16:1) PC 16:0/16:1 C40H78NO8P 731.5465 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/18:1) PC 16:0/18:1 C42H82NO8P 759.5778 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/18:2) PC 16:0/18:2 C42H80NO8P 757.5622 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:1/18:1) PC 16:1/18:1 C42H80NO8P 757.5622 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/18:1) PC 18:0/18:1 C44H86NO8P 787.6091 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/18:1) PC 18:1/18:1 C44H84NO8P 785.5935 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/18:2) PC 18:0/18:2 C44H84NO8P 785.5935 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/20:3) PC 16:0/20:3 C44H82NO8P 783.5778 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/18:2) PC 18:1/18:2 C44H82NO8P 783.5778 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/20:4) PC 16:0/20:4 C44H80NO8P 781.5622 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:1/20:4) PC 16:1/20:4 C44H78NO8P 779.5465 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/22:4) PC 16:0/22:4 C46H84NO8P 809.5935 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/20:3) PC 18:0/20:3 C46H86NO8P 811.6091 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/20:4) PC 18:0/20:4 C46H84NO8P 809.5935 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/20:3) PC 18:1/20:3 C46H84NO8P 809.5935 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/20:4) PC 18:1/20:4 C46H82NO8P 807.5778 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/22:5) PC 16:0/22:5 C46H82NO8P 807.5778 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(16:0/22:6) PC 16:0/22:6 C46H80NO8P 805.5622 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/22:5) PC 18:0/22:5 C48H86NO8P 835.6091 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/22:4) PC 18:0/22:4 C48H88NO8P 837.6248 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/22:4) PC 18:1/22:4 C48H86NO8P 835.6091 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:0/22:6) PC 18:0/22:6 C48H84NO8P 833.5935 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/22:5) PC 18:1/22:5 C48H84NO8P 833.5935 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine 1-palmitoyl-2-linoleoylphosphatidylcholine(18:1/22:6) PC 18:1/22:6 C48H82NO8P 831.5778 Glycerophospholipids Glycerophosphocholines 1-palmitoyl-2-linoleoylphosphatidylcholine METABOLITES_END #END