#METABOLOMICS WORKBENCH amitch_20210331_061523 DATATRACK_ID:2550 STUDY_ID:ST001742 ANALYSIS_ID:AN002835 PROJECT_ID:PR001115 VERSION 1 CREATED_ON April 15, 2021, 2:12 pm #PROJECT PR:PROJECT_TITLE Utility of canine diabetes as a model for human type 1 diabetes (part-I) PR:PROJECT_SUMMARY We are examining the etiopathogenesis of canine diabetes to determine the PR:PROJECT_SUMMARY relevance of these animals as a naturally occurring model of human type 1 PR:PROJECT_SUMMARY diabetes. We will undertake phenotypic, metabolic, and immunologic PR:PROJECT_SUMMARY investigations in diabetic dogs to better characterize their diabetes and PR:PROJECT_SUMMARY attempt to identify potential biomarkers of a pre-diabetic state. PR:INSTITUTE University of Florida PR:DEPARTMENT Diabetes Institute (Wasserfall/Atkinson)/College of Veterinary Medicine (O'Kell) PR:LAST_NAME O'Kell PR:FIRST_NAME Allison PR:ADDRESS 2015 SW 16th Ave PR:EMAIL aokell@ufl.edu PR:PHONE 352-294-4471 #STUDY ST:STUDY_TITLE Metabolomic Analysis of Canine Diabetes (part-I) ST:STUDY_TYPE Single time point blood collection ST:STUDY_SUMMARY Blood was collected from diabetic dogs and healthy control dogs. Diabetic dogs ST:STUDY_SUMMARY and control dogs were breed matched where possible. Timing of blood collection ST:STUDY_SUMMARY after a meal was matched as best as posible. Serum was frozen at -80C. ST:INSTITUTE University of Florida ST:LAST_NAME O'Kell ST:FIRST_NAME Allison ST:ADDRESS 2015 SW 16th Ave ST:EMAIL aokell@ufl.edu ST:PHONE 3522944471 ST:NUM_GROUPS 2 ST:TOTAL_SUBJECTS 80 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Canis lupus familiaris SU:TAXONOMY_ID 9615 SU:AGE_OR_AGE_RANGE Adult SU:WEIGHT_OR_WEIGHT_RANGE 3-60 kg #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - 321588 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_5[321588]p; RAW_FILE_NAME=QE2_jdg_191_Okell_5[321588]p; RAW_FILE_NAME=QE2_jdg_188_Okell_5[321588]n; RAW_FILE_NAME=QE1_jdg_59_Okell_5[321588]n; RAW_FILE_NAME=QE2_jdg_276_Okell_5[321588]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 325942 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_6[325942]p; RAW_FILE_NAME=QE2_jdg_191_Okell_6[325942]p; RAW_FILE_NAME=QE2_jdg_188_Okell_6[325942]n; RAW_FILE_NAME=QE1_jdg_59_Okell_6[325942]n; RAW_FILE_NAME=QE2_jdg_276_Okell_6[325942]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 313390 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_7[313390]p; RAW_FILE_NAME=QE2_jdg_191_Okell_7[313390]p; RAW_FILE_NAME=QE2_jdg_188_Okell_7[313390]n; RAW_FILE_NAME=QE1_jdg_59_Okell_7[313390]n; RAW_FILE_NAME=QE2_jdg_276_Okell_7[313390]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 213267 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_9[213267]p; RAW_FILE_NAME=QE2_jdg_191_Okell_9[213267]p; RAW_FILE_NAME=QE2_jdg_188_Okell_9[213267]n; RAW_FILE_NAME=QE1_jdg_59_Okell_9[213267]n; RAW_FILE_NAME=QE2_jdg_276_Okell_9[213267]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 213269 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_10[213269]p; RAW_FILE_NAME=QE2_jdg_191_Okell_10[213269]p; RAW_FILE_NAME=QE2_jdg_188_Okell_10[213269]n; RAW_FILE_NAME=QE1_jdg_59_Okell_10[213269]n; RAW_FILE_NAME=QE2_jdg_276_Okell_10[213269]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 325103 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_11[325103]p; RAW_FILE_NAME=QE2_jdg_191_Okell_11[325103]p; RAW_FILE_NAME=QE2_jdg_188_Okell_11[325103]n; RAW_FILE_NAME=QE1_jdg_59_Okell_11[325103]n; RAW_FILE_NAME=QE2_jdg_276_Okell_11[325103]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 269031 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_1[269031]p; RAW_FILE_NAME=QE2_jdg_191_Okell_1[269031]p; RAW_FILE_NAME=QE2_jdg_188_Okell_1[269031]n; RAW_FILE_NAME=QE1_jdg_59_Okell_1[269031]n; RAW_FILE_NAME=QE2_jdg_276_Okell_1[269031]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 279436 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_2[279436]p; RAW_FILE_NAME=QE2_jdg_191_Okell_2[279436]p; RAW_FILE_NAME=QE2_jdg_188_Okell_2[279436]n; RAW_FILE_NAME=QE1_jdg_59_Okell_2[279436]n; RAW_FILE_NAME=QE2_jdg_276_Okell_2[279436]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 323294 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_3[323294]p; RAW_FILE_NAME=QE2_jdg_191_Okell_3[323294]p; RAW_FILE_NAME=QE2_jdg_188_Okell_3[323294]n; RAW_FILE_NAME=QE1_jdg_59_Okell_3[323294]n; RAW_FILE_NAME=QE2_jdg_276_Okell_3[323294]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 309443 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_4[309443]p; RAW_FILE_NAME=QE2_jdg_191_Okell_4[309443]p; RAW_FILE_NAME=QE2_jdg_188_Okell_4[309443]n; RAW_FILE_NAME=QE1_jdg_59_Okell_4[309443]n; RAW_FILE_NAME=QE2_jdg_276_Okell_4[309443]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 216422 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_8[216422]p; RAW_FILE_NAME=QE2_jdg_191_Okell_8[216422]p; RAW_FILE_NAME=QE2_jdg_188_Okell_8[216422]n; RAW_FILE_NAME=QE1_jdg_59_Okell_8[216422]n; RAW_FILE_NAME=QE2_jdg_276_Okell_8[216422]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 325643 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_12[325643]p; RAW_FILE_NAME=QE2_jdg_191_Okell_12[325643]p; RAW_FILE_NAME=QE2_jdg_188_Okell_12[325643]n; RAW_FILE_NAME=QE1_jdg_59_Okell_12[325643]n; RAW_FILE_NAME=QE2_jdg_276_Okell_12[325643]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 325866 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_17[325866]p; RAW_FILE_NAME=QE2_jdg_191_Okell_17[325866]p; RAW_FILE_NAME=QE2_jdg_188_Okell_17[325866]n; RAW_FILE_NAME=QE1_jdg_59_Okell_17[325866]n; RAW_FILE_NAME=QE2_jdg_276_Okell_17[325866]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 295029 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_18[295029]p; RAW_FILE_NAME=QE2_jdg_191_Okell_18[295029]p; RAW_FILE_NAME=QE2_jdg_188_Okell_18[295029]n; RAW_FILE_NAME=QE1_jdg_59_Okell_18[295029]n; RAW_FILE_NAME=QE2_jdg_276_Okell_18[295029]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 228415 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_20[228415]p; RAW_FILE_NAME=QE2_jdg_191_Okell_20[228415]p; RAW_FILE_NAME=QE2_jdg_188_Okell_20[228415]n; RAW_FILE_NAME=QE1_jdg_59_Okell_20[228415]n; RAW_FILE_NAME=QE2_jdg_276_Okell_20[228415]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 255293 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_21[255293]p; RAW_FILE_NAME=QE2_jdg_191_Okell_21[255293]p; RAW_FILE_NAME=QE2_jdg_188_Okell_21[255293]n; RAW_FILE_NAME=QE1_jdg_59_Okell_21[255293]n; RAW_FILE_NAME=QE2_jdg_276_Okell_21[255293]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 288261 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_22[288261]p; RAW_FILE_NAME=QE2_jdg_191_Okell_22[288261]p; RAW_FILE_NAME=QE2_jdg_188_Okell_22[288261]n; RAW_FILE_NAME=QE1_jdg_59_Okell_22[288261]n; RAW_FILE_NAME=QE2_jdg_276_Okell_22[288261]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 290374 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_188_Okell_23[290374]p; RAW_FILE_NAME=QE2_jdg_191_Okell_23[290374]p; RAW_FILE_NAME=QE2_jdg_188_Okell_23[290374]n; RAW_FILE_NAME=QE1_jdg_59_Okell_23[290374]n; RAW_FILE_NAME=QE2_jdg_276_Okell_23[290374]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 296735 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_13[296735]p; RAW_FILE_NAME=QE2_jdg_191_Okell_13[296735]p; RAW_FILE_NAME=QE2_jdg_188_Okell_13[296735]n; RAW_FILE_NAME=QE1_jdg_59_Okell_13[296735]n; RAW_FILE_NAME=QE2_jdg_276_Okell_13[296735]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 290195 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_14[290195]p; RAW_FILE_NAME=QE2_jdg_191_Okell_14[290195]p; RAW_FILE_NAME=QE2_jdg_188_Okell_14[290195]n; RAW_FILE_NAME=QE1_jdg_59_Okell_14[290195]n; RAW_FILE_NAME=QE2_jdg_276_Okell_14[290195]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 326077 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_15[326077]p; RAW_FILE_NAME=QE2_jdg_191_Okell_15[326077]p; RAW_FILE_NAME=QE2_jdg_188_Okell_15[326077]n; RAW_FILE_NAME=QE1_jdg_59_Okell_15[326077]n; RAW_FILE_NAME=QE2_jdg_276_Okell_15[326077]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 325932 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_16[325932]p; RAW_FILE_NAME=QE2_jdg_191_Okell_16[325932]p; RAW_FILE_NAME=QE2_jdg_188_Okell_16[325932]n; RAW_FILE_NAME=QE1_jdg_59_Okell_16[325932]n; RAW_FILE_NAME=QE2_jdg_276_Okell_16[325932]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 223169 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_19[223169]p; RAW_FILE_NAME=QE2_jdg_191_Okell_19[223169]p; RAW_FILE_NAME=QE2_jdg_188_Okell_19[223169]n; RAW_FILE_NAME=QE1_jdg_59_Okell_19[223169]n; RAW_FILE_NAME=QE2_jdg_276_Okell_19[223169]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 287971 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_188_Okell_24[287971]p; RAW_FILE_NAME=QE2_jdg_191_Okell_24[287971]p; RAW_FILE_NAME=QE2_jdg_188_Okell_24[287971]n; RAW_FILE_NAME=QE1_jdg_59_Okell_24[287971]n; RAW_FILE_NAME=QE2_jdg_276_Okell_24[287971]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 349833 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_39[349833]p; RAW_FILE_NAME=QE2_jdg_190_Okell_39[349833]p; RAW_FILE_NAME=QE2_jdg_187_Okell_39[349833]n; RAW_FILE_NAME=QE1_jdg_58_Okell_39[349833]n; RAW_FILE_NAME=QE2_jdg_275_Okell_39[349833]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 313074 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_25[313074]p; RAW_FILE_NAME=QE2_jdg_190_Okell_25[313074]p; RAW_FILE_NAME=QE2_jdg_187_Okell_25[313074]n; RAW_FILE_NAME=QE1_jdg_58_Okell_25[313074]n; RAW_FILE_NAME=QE2_jdg_275_Okell_25[313074]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 325419 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_26[325419]p; RAW_FILE_NAME=QE2_jdg_190_Okell_26[325419]p; RAW_FILE_NAME=QE2_jdg_187_Okell_26[325419]n; RAW_FILE_NAME=QE1_jdg_58_Okell_26[325419]n; RAW_FILE_NAME=QE2_jdg_275_Okell_26[325419]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 329649 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_27[329649]p; RAW_FILE_NAME=QE2_jdg_190_Okell_27[329649]p; RAW_FILE_NAME=QE2_jdg_187_Okell_27[329649]n; RAW_FILE_NAME=QE1_jdg_58_Okell_27[329649]n; RAW_FILE_NAME=QE2_jdg_275_Okell_27[329649]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 353791 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_28[353791]p; RAW_FILE_NAME=QE2_jdg_190_Okell_28[353791]p; RAW_FILE_NAME=QE2_jdg_187_Okell_28[353791]n; RAW_FILE_NAME=QE1_jdg_58_Okell_28[353791]n; RAW_FILE_NAME=QE2_jdg_275_Okell_28[353791]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 355594 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_29[355594]p; RAW_FILE_NAME=QE2_jdg_190_Okell_29[355594]p; RAW_FILE_NAME=QE2_jdg_187_Okell_29[355594]n; RAW_FILE_NAME=QE1_jdg_58_Okell_29[355594]n; RAW_FILE_NAME=QE2_jdg_275_Okell_29[355594]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 349937 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_30[349937]p; RAW_FILE_NAME=QE2_jdg_190_Okell_30[349937]p; RAW_FILE_NAME=QE2_jdg_187_Okell_30[349937]n; RAW_FILE_NAME=QE1_jdg_58_Okell_30[349937]n; RAW_FILE_NAME=QE2_jdg_275_Okell_30[349937]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 354675 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_31[354675]p; RAW_FILE_NAME=QE2_jdg_190_Okell_31[354675]p; RAW_FILE_NAME=QE2_jdg_187_Okell_31[354675]n; RAW_FILE_NAME=QE1_jdg_58_Okell_31[354675]n; RAW_FILE_NAME=QE2_jdg_275_Okell_31[354675]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 346336 Group:Diabetic | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_32[346336]p; RAW_FILE_NAME=QE2_jdg_190_Okell_32[346336]p; RAW_FILE_NAME=QE2_jdg_187_Okell_32[346336]n; RAW_FILE_NAME=QE1_jdg_58_Okell_32[346336]n; RAW_FILE_NAME=QE2_jdg_275_Okell_32[346336]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 319373 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_33[319373]p; RAW_FILE_NAME=QE2_jdg_190_Okell_33[319373]p; RAW_FILE_NAME=QE2_jdg_187_Okell_33[319373]n; RAW_FILE_NAME=QE1_jdg_58_Okell_33[319373]n; RAW_FILE_NAME=QE2_jdg_275_Okell_33[319373]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 327679 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_34[327679]p; RAW_FILE_NAME=QE2_jdg_190_Okell_34[327679]p; RAW_FILE_NAME=QE2_jdg_187_Okell_34[327679]n; RAW_FILE_NAME=QE1_jdg_58_Okell_34[327679]n; RAW_FILE_NAME=QE2_jdg_275_Okell_34[327679]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 308098 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_35[308098]p; RAW_FILE_NAME=QE2_jdg_190_Okell_35[308098]p; RAW_FILE_NAME=QE2_jdg_187_Okell_35[308098]n; RAW_FILE_NAME=QE1_jdg_58_Okell_35[308098]n; RAW_FILE_NAME=QE2_jdg_275_Okell_35[308098]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 333987 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_36[333987]p; RAW_FILE_NAME=QE2_jdg_190_Okell_36[333987]p; RAW_FILE_NAME=QE2_jdg_187_Okell_36[333987]n; RAW_FILE_NAME=QE1_jdg_58_Okell_36[333987]n; RAW_FILE_NAME=QE2_jdg_275_Okell_36[333987]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 348332 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_37[348332]p; RAW_FILE_NAME=QE2_jdg_190_Okell_37[348332]p; RAW_FILE_NAME=QE2_jdg_187_Okell_37[348332]n; RAW_FILE_NAME=QE1_jdg_58_Okell_37[348332]n; RAW_FILE_NAME=QE2_jdg_275_Okell_37[348332]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 242045 Group:Diabetic | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_38[242045]p; RAW_FILE_NAME=QE2_jdg_190_Okell_38[242045]p; RAW_FILE_NAME=QE2_jdg_187_Okell_38[242045]n; RAW_FILE_NAME=QE1_jdg_58_Okell_38[242045]n; RAW_FILE_NAME=QE2_jdg_275_Okell_38[242045]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 360399 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_54[360399]p; RAW_FILE_NAME=QE2_jdg_190_Okell_54[360399]p; RAW_FILE_NAME=QE2_jdg_187_Okell_54[360399]n; RAW_FILE_NAME=QE1_jdg_58_Okell_54[360399]n; RAW_FILE_NAME=QE2_jdg_275_Okell_54[360399]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 344481 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_40[344481]p; RAW_FILE_NAME=QE2_jdg_190_Okell_40[344481]p; RAW_FILE_NAME=QE2_jdg_187_Okell_40[344481]n; RAW_FILE_NAME=QE1_jdg_58_Okell_40[344481]n; RAW_FILE_NAME=QE2_jdg_275_Okell_40[344481]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 292894 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_41[292894]p; RAW_FILE_NAME=QE2_jdg_190_Okell_41[292894]p; RAW_FILE_NAME=QE2_jdg_187_Okell_41[292894]n; RAW_FILE_NAME=QE1_jdg_58_Okell_41[292894]n; RAW_FILE_NAME=QE2_jdg_275_Okell_41[292894]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 243765 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_42[243765]p; RAW_FILE_NAME=QE2_jdg_190_Okell_42[243765]p; RAW_FILE_NAME=QE2_jdg_187_Okell_42[243765]n; RAW_FILE_NAME=QE1_jdg_58_Okell_42[243765]n; RAW_FILE_NAME=QE2_jdg_275_Okell_42[243765]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 359130 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_43[359130]p; RAW_FILE_NAME=QE2_jdg_190_Okell_43[359130]p; RAW_FILE_NAME=QE2_jdg_187_Okell_43[359130]n; RAW_FILE_NAME=QE1_jdg_58_Okell_43[359130]n; RAW_FILE_NAME=QE2_jdg_275_Okell_43[359130]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 355837 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_44[355837]p; RAW_FILE_NAME=QE2_jdg_190_Okell_44[355837]p; RAW_FILE_NAME=QE2_jdg_187_Okell_44[355837]n; RAW_FILE_NAME=QE1_jdg_58_Okell_44[355837]n; RAW_FILE_NAME=QE2_jdg_275_Okell_44[355837]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 309999 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_45[309999]p; RAW_FILE_NAME=QE2_jdg_190_Okell_45[309999]p; RAW_FILE_NAME=QE2_jdg_187_Okell_45[309999]n; RAW_FILE_NAME=QE1_jdg_58_Okell_45[309999]n; RAW_FILE_NAME=QE2_jdg_275_Okell_45[309999]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 301154 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_46[301154]p; RAW_FILE_NAME=QE2_jdg_190_Okell_46[301154]p; RAW_FILE_NAME=QE2_jdg_187_Okell_46[301154]n; RAW_FILE_NAME=QE1_jdg_58_Okell_46[301154]n; RAW_FILE_NAME=QE2_jdg_275_Okell_46[301154]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 298006 Group:Healthy | Fasted vs Fed:Fasted RAW_FILE_NAME=QE2_jdg_187_Okell_47[298006]p; RAW_FILE_NAME=QE2_jdg_190_Okell_47[298006]p; RAW_FILE_NAME=QE2_jdg_187_Okell_47[298006]n; RAW_FILE_NAME=QE1_jdg_58_Okell_47[298006]n; RAW_FILE_NAME=QE2_jdg_275_Okell_47[298006]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 277908 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_48[277908]p; RAW_FILE_NAME=QE2_jdg_190_Okell_48[277908]p; RAW_FILE_NAME=QE2_jdg_187_Okell_48[277908]n; RAW_FILE_NAME=QE1_jdg_58_Okell_48[277908]n; RAW_FILE_NAME=QE2_jdg_275_Okell_48[277908]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 280189 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_49[280189]p; RAW_FILE_NAME=QE2_jdg_190_Okell_49[280189]p; RAW_FILE_NAME=QE2_jdg_187_Okell_49[280189]n; RAW_FILE_NAME=QE1_jdg_58_Okell_49[280189]n; RAW_FILE_NAME=QE2_jdg_275_Okell_49[280189]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 328335 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_50[328335]p; RAW_FILE_NAME=QE2_jdg_190_Okell_50[328335]p; RAW_FILE_NAME=QE2_jdg_187_Okell_50[328335]n; RAW_FILE_NAME=QE1_jdg_58_Okell_50[328335]n; RAW_FILE_NAME=QE2_jdg_275_Okell_50[328335]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 232368 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_51[232368]p; RAW_FILE_NAME=QE2_jdg_190_Okell_51[232368]p; RAW_FILE_NAME=QE2_jdg_187_Okell_51[232368]n; RAW_FILE_NAME=QE1_jdg_58_Okell_51[232368]n; RAW_FILE_NAME=QE2_jdg_275_Okell_51[232368]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 295509 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_52[295509]p; RAW_FILE_NAME=QE2_jdg_190_Okell_52[295509]p; RAW_FILE_NAME=QE2_jdg_187_Okell_52[295509]n; RAW_FILE_NAME=QE1_jdg_58_Okell_52[295509]n; RAW_FILE_NAME=QE2_jdg_275_Okell_52[295509]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p SUBJECT_SAMPLE_FACTORS - 274821 Group:Healthy | Fasted vs Fed:Fed RAW_FILE_NAME=QE2_jdg_187_Okell_53[274821]p; RAW_FILE_NAME=QE2_jdg_190_Okell_53[274821]p; RAW_FILE_NAME=QE2_jdg_187_Okell_53[274821]n; RAW_FILE_NAME=QE1_jdg_58_Okell_53[274821]n; RAW_FILE_NAME=QE2_jdg_275_Okell_53[274821]p; RAW_FILE_NAME=QE2_jdg_289_Okell_1[269031]p #COLLECTION CO:COLLECTION_SUMMARY Blood collected by peripheral venipuncture into red top tube (containing clot CO:COLLECTION_SUMMARY activator). Blood was allowed to clot, then centrifuged at 2000 g x 7.5 minutes CO:COLLECTION_SUMMARY between 25-35 minutes after sample collection. Serum was frozen immediately CO:COLLECTION_SUMMARY after separation (always within 1 hour of collection) at -80 C. CO:COLLECTION_PROTOCOL_FILENAME Protein_Precipitation_Sample_Prep.pdf CO:SAMPLE_TYPE Blood (serum) CO:COLLECTION_METHOD Peripheral venipuncture CO:COLLECTION_LOCATION Jugular, saphenous, or cephalic vein CO:COLLECTION_FREQUENCY Once CO:VOLUMEORAMOUNT_COLLECTED Variable CO:STORAGE_CONDITIONS -80℃ CO:COLLECTION_VIALS Red top with clot activator CO:STORAGE_VIALS Cryovials (polypropylene); Microcentrifuge tubes (polypropylene) for second CO:STORAGE_VIALS round CO:COLLECTION_TUBE_TEMP Room temperature #TREATMENT TR:TREATMENT_SUMMARY None for research study. Variable medications may have been received by diabetic TR:TREATMENT_SUMMARY dogs. Healthy dogs are only allowed to receive flea/tick/heartworm TR:TREATMENT_SUMMARY preventatives. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY TRP Quant_Protein Precipitation Sample Prep.docx SP:SAMPLEPREP_PROTOCOL_FILENAME Protein_Precipitation_Sample_Prep.pdf #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Protein Precipitation Sample Prep.pdf CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Dionex Ultimate 3000 CH:COLUMN_NAME ACE Excel 2 C18-PFP (100 x 2.1mm, 2um) #ANALYSIS AN:ANALYSIS_TYPE MS AN:ANALYSIS_PROTOCOL_FILE Protein_Precipitation_Sample_Prep.pdf #MS MS:INSTRUMENT_NAME Thermo Q Exactive Plus Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Protein Precipitation Sample Prep.pdf #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS ng/mL MS_METABOLITE_DATA_START Samples 213269 325103 325643 279436 323294 309443 321588 325942 313390 216422 213267 269031 296735 290195 326077 325932 325866 295029 223169 228415 255293 288261 290374 287971 313074 325419 329649 353791 355594 349937 354675 346336 319373 327679 308098 333987 348332 242045 349833 344481 292894 243765 359130 355837 309999 301154 298006 277908 280189 328335 232368 295509 274821 360399 Factors Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fasted Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fed Group:Diabetic | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fasted Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fed Group:Healthy | Fasted vs Fed:Fasted 2,6-diaminoheptanedioate 28.60232679 26.95907406 67.72065188 38.45819894 18.44218336 27.49292516 19.33934598 21.72877956 23.3544928 33.55073235 28.4614691 29.08858822 30.27208339 47.37861964 78.90359261 85.56309693 31.75181976 25.61129733 46.96524744 34.92883405 54.77510267 25.46711398 27.2381872 33.81287982 15.02873987 23.36781746 21.56665783 17.93422304 31.16531679 38.58853423 41.08337062 20.27448171 22.71712758 84.50738327 30.4460262 134.9715025 57.09460919 44.34320868 21.29123287 20.70126907 57.00828937 51.2140283 38.87615423 34.44025249 194.9789384 45.94437146 24.95879779 48.47063955 42.86283099 51.49220211 50.75668511 199.1390942 16.45484683 26.70799305 L-Histidine 525.84778 393.4610656 625.0412228 535.7756516 423.6930016 370.4044462 364.4945913 468.7183518 690.6987171 706.8700998 454.0260155 556.1743338 523.3072798 552.784731 575.1130468 475.0595862 471.2076902 482.9637621 453.4345286 573.965932 488.8407105 419.7545864 500.390808 480.8375136 735.2734534 714.1284688 1223.189985 515.5786304 448.6013184 325.9224247 554.96406 340.9873977 640.5767205 681.0161921 713.7959571 566.5836114 762.4091134 645.5755589 656.7959983 545.3493685 506.0515584 535.6961851 378.0290266 557.6106571 500.4231566 467.3856719 671.5348293 505.0994506 707.368346 516.2178622 648.9131052 500.2197513 601.2327455 444.3572094 Glycine 290.7078813 126.6937159 235.0845967 138.3753449 181.6866908 85.13718751 51.51363704 128.3005847 138.6733643 113.0596764 203.9365853 133.0604508 169.2599467 175.6379987 160.791634 192.9283349 110.8563549 178.9850796 143.3320174 202.4627703 325.2083782 100.0949771 215.7014129 141.6573331 154.5593512 175.2148837 197.8137158 86.39244917 71.99500768 127.7471305 111.2489749 59.52568954 188.0444448 217.250516 269.4005309 86.10915475 290.7366879 141.476136 119.5915632 112.6846515 80.28251073 164.8354221 79.62435538 251.4156935 203.206845 75.14718663 177.368951 228.1094278 225.687917 141.4362327 270.1256274 133.0760957 186.9474988 165.5501194 GABA 2166.294838 5126.968717 2955.180518 2945.092551 2782.752543 3138.5984 1424.054983 5777.461924 9376.190598 6124.774304 1485.505652 3441.240159 3430.734561 2078.724828 3055.347493 1271.10033 1538.746279 1890.626537 1700.730197 2291.145676 2522.542197 1235.426952 1348.159725 1759.654597 5462.169803 9801.285915 9247.115122 6258.659627 5717.852832 2679.146095 3390.908789 3795.749491 4073.608267 3305.694562 2569.826338 3000.399679 8626.542174 2675.537474 4994.55752 2273.992072 1399.338973 1724.658582 3000.656089 1088.658392 1465.054967 1787.814549 2066.452662 1397.108714 2428.344219 2686.132109 3578.519936 1910.223631 1412.395573 2038.39415 L-Proline 30554.38278 13292.0658 33807.58335 33368.10198 39699.65604 29687.76047 12497.15409 15939.01975 16039.58676 14385.44412 23870.40386 26336.40035 43100.53514 30198.99103 32010.54781 41629.47612 34916.89971 22030.52424 33290.99005 31056.49297 34559.43056 16074.98414 26042.5687 33548.42336 47470.00689 21411.18837 19626.74909 14280.19958 18049.23776 17617.56429 16050.52219 16956.3332 43887.14581 28406.1868 55732.77226 22402.41364 34411.25748 27976.11607 9551.37359 30263.53273 14220.91838 30455.42598 15478.73097 35516.10612 23670.37081 14889.89221 28228.67904 36565.23248 52154.83263 43198.28895 45673.46643 23783.30987 47818.61902 37745.98828 N-acetyl-L-aspartic_Acid 44.86266058 25.23609615 50.87925946 38.97798461 32.78474292 41.3414059 46.08612967 41.2490644 48.17093454 45.03821334 43.3417417 34.66774725 56.56097911 64.39713752 60.53857076 59.75104505 88.98855048 99.49881229 56.41875744 65.76452954 53.91229642 116.936498 66.92830876 82.23214835 46.61390811 66.58686929 48.56840803 55.05467571 51.24853142 37.57579827 48.689703 37.57647989 71.1846932 59.39354203 47.89220413 50.10744864 74.49633857 62.35400537 45.22617838 50.81482895 88.28577856 63.19641171 55.0788072 78.45490651 52.49323418 105.477712 65.91767692 107.3957107 125.1433703 57.42255274 78.15901748 46.73294796 68.4319079 87.40428609 Pyridoxal 37.77845197 48.70124787 54.58640944 42.53586812 56.23233708 20.1227462 <LLQ 50.94380169 328.6712136 157.3865561 20.41229863 25.98625737 98.50316902 50.60845697 22.19158077 19.37856893 58.88654794 5.228778366 44.99648477 68.84204101 127.5798429 111.6689584 59.93827344 29.47114826 168.2364498 83.84908458 20.50238967 25.64148871 88.17626815 107.8212996 88.33914485 43.47838774 59.89115429 24.82191505 48.02538856 92.36135066 392.6248833 237.7495614 38.5659284 94.37708899 74.66253427 72.76732125 90.27609948 126.6159324 80.16207939 99.14283512 53.1819361 71.31692255 118.4727222 64.75302083 151.1602871 105.8517443 122.7200701 69.95526289 Isoleucine 9673.727702 12331.68889 24369.36779 9715.145596 17815.75638 9158.894704 5942.705083 16870.84923 58784.33918 47097.92783 9491.138124 12761.78155 13678.6814 9488.726665 8916.964211 8026.517356 7468.405767 10804.05218 9142.790599 8106.042018 8585.065327 6014.676955 7009.953192 8144.348033 14471.91822 63444.63482 22873.2338 19577.20501 15542.71439 9093.129465 10309.15585 7868.477813 15899.47358 14237.17666 13666.2421 14296.04443 26599.4747 20558.85082 12729.10914 12346.9538 5647.662222 9040.132014 9069.175817 4602.607829 7159.061163 5073.537323 13819.35322 9340.944548 10839.32411 12022.03658 13830.35384 8590.457211 6475.578515 5713.815391 Citramalate 23.19046427 71.70179872 61.95687339 38.24289689 36.52788629 38.11073856 33.02440046 82.94073216 136.4804277 126.5162935 22.75803679 47.44147333 25.85757685 19.12324614 31.60888472 25.32244156 25.72485328 21.97447829 23.99330464 17.84786488 43.27785413 23.82093595 21.08470738 28.29169102 101.8460648 300.4107475 1876.565686 181.0027097 136.7332773 61.28839221 94.54981867 64.6119919 67.1567417 125.6181653 68.94057577 62.77526923 139.7284615 106.2494941 551.8659937 77.80021717 62.0130373 42.27004604 115.6095058 28.43724001 43.20618949 50.90928937 35.44518896 38.93085674 36.36706683 84.46576203 48.52298905 68.21665513 40.09451959 48.53054662 Leucine 22774.40476 27021.66408 50873.54555 31671.46685 46838.49431 22697.13341 12285.39457 42986.60773 74286.5256 59984.55686 23257.34741 30540.55948 34043.25505 30043.47891 21169.97453 18154.40205 21950.16923 23464.25482 23093.8523 31120.00215 22437.66291 11622.33858 19198.1414 22697.83824 39825.4733 89882.48621 58985.67447 45590.36817 33933.79407 24239.59392 27488.75663 22361.70253 43088.93803 33422.83779 30461.2562 36138.77714 58182.72065 51865.37065 26062.86601 31808.19809 10383.21487 20745.02904 20783.24046 13882.39314 14701.74815 10541.52336 34368.79307 27820.47309 42121.87094 30250.34958 42379.7383 17726.41642 23551.83223 18489.3073 5-hydroxymethyl-2-furaldehyde 6.392339286 3.508124792 10.91480872 3.627577987 6.817273502 8.897851826 4.40283704 5.192518633 14.88703205 14.4979182 16.24609734 3.644748355 6.87894149 6.257605987 6.563967268 4.288179596 7.029390939 4.912440569 4.034452254 10.86824845 6.768934057 7.108059913 4.719547083 6.026747213 7.091585371 9.89744604 15.76206629 5.195388551 7.320597283 6.099251084 6.97366592 4.146259126 5.80179969 6.845811713 14.41960503 12.79962861 8.353208935 7.53904853 10.91257184 9.77289847 2.006630117 9.109775598 14.40905702 3.483861703 6.029522194 3.983080974 4.687685745 4.755596829 8.692995643 10.4955527 5.435803319 6.19814812 7.020017848 8.004050357 Kynurenine 1195.873035 194.6744616 481.6277147 644.2221128 505.774731 703.5075016 662.3276412 413.3708868 240.6235554 487.9128431 962.6706991 417.9045938 1138.686292 782.12527 889.0312332 1442.587213 1101.691885 592.3357822 1271.270524 1142.506236 1441.413187 1583.484856 444.9103015 799.9578413 428.8281734 345.7003603 303.3625845 428.5325347 284.7596093 436.987243 364.578975 501.6706519 448.0623733 723.3460136 566.5226291 894.2803346 424.9060464 1055.620429 159.9241487 806.5875882 427.4243068 646.7738161 560.6071025 650.0705269 786.3579519 572.0590863 713.8518628 537.9850073 1624.966765 1403.504469 1105.785825 482.2030014 439.9820386 556.2406336 Serotonin 987.3462098 1548.127121 913.252589 1214.532655 1632.952816 1286.354832 752.65739 1700.257894 867.044015 514.9848319 655.4432265 721.2287506 1613.338468 647.6653883 867.3219655 734.0541656 1587.813925 993.2751304 856.3368532 573.251195 608.5560396 1832.916344 1008.838276 1690.141526 1847.939314 2176.03393 1023.041917 1094.718251 1397.614961 207.5309225 972.6320413 394.6884412 1498.80916 785.9340414 1494.204179 1354.811671 2080.820184 1812.553734 2222.103862 2044.681885 708.2884026 1328.013246 1704.967184 1287.115781 1500.627858 2058.497043 1541.925668 1144.844034 1696.909778 926.0927769 997.2225933 1544.427134 422.8265172 1098.95964 Xanthurenic Acid 10.74924428 2.436947488 15.13863123 11.77537254 11.43926887 4.939468039 4.498143097 7.669577016 3.388410619 8.833855071 12.94362006 10.98156865 8.470604177 3.257899885 23.00999588 41.08249064 10.54554003 8.005834037 4.439456549 3.748744112 10.09337189 3.086850646 7.526440803 5.883917988 12.58420131 20.46001174 15.08450579 4.384516221 9.899030549 16.14793148 6.776730386 4.112344785 14.39484184 37.35653435 7.543642742 12.0885999 51.02313605 4.055381844 6.644234545 4.729727446 4.855742359 33.6213277 23.86561459 11.75110039 11.06367171 6.43289514 12.18461765 13.50513253 2.230571467 3.386645352 4.977374658 68.78106455 2.537053375 7.229796442 Tryptophan 43093.65336 14811.07676 39357.39372 38739.27458 48776.92505 39723.79812 30772.89072 31648.78612 18406.23675 38129.5038 39453.24126 41644.44961 39417.56995 53720.04607 52121.40873 47860.12725 45814.30524 27096.07796 58166.75671 48732.07091 51802.69484 35160.26575 25378.47518 32768.59594 28900.80163 15693.16254 18830.27737 31044.76606 33636.49 23148.03833 30276.94345 57219.03842 34815.88436 27717.01276 42304.77248 51212.68465 18711.68885 49060.64001 15347.24537 32611.80503 20994.64614 35376.15971 45530.54778 20521.51562 30758.58874 26244.00484 30927.3626 23440.67959 57065.74993 92415.5063 35034.75894 34751.24675 42314.37327 35854.63951 Kynurenic Acid 1024.101416 198.5126872 1250.398297 402.5124426 579.7318719 1213.861173 1031.830654 1204.704091 214.905163 576.4770957 229.4631396 584.8075737 1919.484965 180.0342584 1028.796235 2485.316214 706.5439246 365.9468188 1151.081061 157.7295761 1033.40908 1501.349176 998.6116654 250.3939106 1686.830416 4084.083447 544.0042184 293.926029 766.2937991 391.491252 751.9814054 791.7910261 846.0049212 5046.77847 465.9821196 968.4825315 591.9440984 670.5008353 227.2412372 2342.096399 917.6307994 2263.862125 2811.885908 1906.459724 703.1860737 612.5970463 2220.974273 984.9645065 155.1493007 376.1749731 299.2117769 520.3275507 112.4039507 761.376946 Anthranilic Acid 15.82498698 5.263449809 16.8405711 23.96210699 7.141057193 15.6383434 14.76813517 10.34557792 6.694297489 8.735853444 10.23251016 5.782625661 28.93316981 44.11791488 12.80368407 56.21449232 25.12381868 21.05342107 38.47294933 19.38540371 38.36998448 34.36423852 20.03718721 34.47853811 12.79127089 18.71432063 3.954790316 13.13583241 7.740948127 13.99634318 7.673885187 6.804079154 14.22241258 39.40408109 7.39657364 10.06638137 12.74068831 31.72018279 6.378753611 16.4090174 19.79312077 12.81409116 9.562101201 16.49699689 15.52426375 30.04617226 16.99109632 12.97483847 45.96232383 21.31252691 30.25547902 6.88487023 9.952883416 12.74049231 Tauroursodeoxycholic acid 14.91169771 17.77636008 36.99470801 31.03281853 98.30878041 34.86194001 BLOQ 14.82407457 BLOQ 20.35196175 15.45130019 43.82831999 23.54980368 64.18567834 190.9079167 58.73052616 102.8082532 BLOQ 51.89021296 60.24770813 20.1897511 35.62277639 33.89409565 131.2508591 6.640289543 59.20013029 15.38835562 26.73483922 10.6154613 BLOQ BLOQ 5.585151681 74.56224534 7.558976814 5.230401507 BLOQ 7.33161488 BLOQ 16.24753663 0.1 43.95107363 27.83157053 41.70779394 15.69815086 8.559147581 21.62765458 18.48125134 44.49422449 28.50512574 21.13123634 38.07532666 30.39783522 124.068355 20.76575735 Glucosamine/Mannosamine 13247 17177 28771 26798 13624 22192 11463 14832 19970 51883 39961 21531 13891 20222 6932 10470 17056 40192 12777 13655 6901 8372 14739 16291 42696 71427 48814 33719 39448 34532 49216 7879 37263 21989 13189 38437 69242 47120 23155 48921 18334 18697 20412 11139 23416 16037 20583 27338 29784 35068 36150 20835 7827 17489 D-Galacturonic Acid 51.45394169 14.64970061 96.97436347 77.64565972 5.39218866 BLOQ BLOQ 105.1154364 79.79710954 113.6227241 28.45404736 210.7527447 BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ 129.2043065 274.5070525 343.1754989 113.6957453 BLOQ 51.1404486 72.9284412 BLOQ 49.51693145 134.6645881 71.87428121 42.92460475 204.4443711 130.5203344 151.6445248 BLOQ BLOQ BLOQ 19.16942613 BLOQ 3.703474461 BLOQ BLOQ BLOQ BLOQ 18.74732975 BLOQ BLOQ BLOQ BLOQ Methyl-β-D-galactoside BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ 353.7854559 351.081673 BLOQ 3102.832915 BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ 575.7317668 129.3537186 BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ BLOQ 609.6430366 BLOQ BLOQ BLOQ BLOQ 72.35377893 84.63701637 474.5961514 BLOQ BLOQ Uridine 87.84284298 40.45101663 68.92197918 54.69726742 218.6892894 107.7206727 142.0583308 131.9771585 178.0492471 40.06218308 157.7253988 222.486886 24.53958251 84.2048651 115.4170242 7.490369836 9.225941334 69.15299566 3.197687013 37.76662629 93.91513689 1.622020996 15.35624871 9.904418556 186.3037662 178.2614514 143.739727 423.064323 100.8470147 51.05694691 99.14213301 49.42700256 BLOQ 54.29420305 115.6524718 117.4691205 154.2586257 657.2940174 159.146603 141.1136437 BLOQ BLOQ 47.14471917 BLOQ 46.3486777 BLOQ 51.79747662 BLOQ 7.030947768 43.77047802 14.29171667 BLOQ 64.18310531 47.41513174 Tyrosine 15907.6783 7727.990333 10964.80441 11287.60307 17810.12096 11555.1075 6668.813631 15490.79793 13011.00766 11800.66492 15650.98763 9228.226398 16598.08847 19408.51667 18448.61136 18507.05459 9813.741838 14592.50347 14134.86569 17075.21417 20697.95412 10148.24596 13605.18346 14194.23077 14543.73761 17425.57487 13921.12614 9517.67386 12312.09362 11065.83063 9383.040628 11952.1336 15474.53808 18737.44976 14766.55988 14820.93266 16699.50889 12730.32688 5614.147378 17198.06169 8369.190568 20731.58081 13854.65557 13294.74692 15922.22634 9564.227296 16095.60985 13078.74265 17447.97459 22753.58502 18865.62319 11569.21813 30474.85584 18840.98245 Indoxyl Sulfate 635.6743841 564.1797299 4014.63405 963.7018651 9317.409227 1268.706498 897.5364011 2004.620828 1171.015023 6945.805966 2374.420838 1305.026405 614.6421567 8283.748322 2125.907775 8434.009827 11300.82337 523.0296486 12805.6949 8069.549109 11456.15511 15509.19251 5812.186737 10951.83096 1830.99591 2305.944518 2687.567773 2904.41417 3327.574018 2268.04399 2611.941116 190.7791897 3557.564425 1393.826808 208.6797626 189.3002826 1723.715959 4512.203766 489.5744109 15291.2935 1312.886023 8507.4671 5158.060821 37410.76324 6358.868908 9551.954992 2523.411716 14640.29787 4307.249737 21319.7335 17536.08385 5172.530194 3259.728975 2745.402911 L-Glutamine 138401.459 90058.14672 103718.2774 93135.94405 101458.1279 127600.4823 98224.12823 78560.4998 66884.09142 74750.69479 139734.7879 95184.63452 137271.3163 132900.7074 111729.4482 114137.5465 111741.9478 112754.9283 117129.8014 113182.7075 173281.2107 95505.88157 161716.2477 117364.2983 69875.60786 78646.77282 65312.98529 98839.88618 101099.016 112145.0426 90820.55213 91605.88966 132543.9373 102644.2613 141746.2363 93307.20022 98972.87459 85562.22952 68807.8551 105833.4273 106167.5668 138592.9464 95126.28006 114341.6704 123782.3594 111358.9039 133654.2849 111799.4327 136180.5276 81838.67196 141374.4241 112155.8486 187057.5384 109812.6667 Aspartate 602.4521282 562.258245 544.5897703 455.8948233 752.321674 685.5491058 703.450699 351.0256318 441.3569816 793.6813074 863.7467866 597.2226265 570.0315252 516.1019056 839.0090372 584.0326397 597.6706212 1298.883899 579.293206 741.8745409 956.0792376 835.172663 451.0484593 1850.2406 550.4239501 705.60858 713.4764603 266.7322365 422.6758837 391.9905678 379.9625815 749.3364268 884.4872718 1702.321975 664.0691091 622.1611192 773.4878614 1102.550679 673.8675982 588.1901063 389.168002 580.3344037 908.7220538 544.6729219 795.4306972 411.7674027 480.4816502 746.7497901 560.0961391 874.8601104 684.6116172 501.5094549 628.8015233 674.2418789 Valine 21565.79682 32597.20287 57679.99317 24711.01729 40536.74716 27395.38383 16447.6646 39988.21861 75771.17468 61165.50182 21482.39378 36671.60129 25242.92461 23716.39762 22001.6516 20171.02626 15787.65349 21511.95478 21717.34395 20745.84301 20759.02907 17039.65431 18188.59105 17082.52962 34486.28474 87971.52754 56866.32953 54316.55098 34134.67796 28936.96104 34036.5827 28284.667 37041.78808 37171.67127 29599.35665 38327.29668 60306.50266 48080.1441 26842.57566 30358.3638 12647.65848 21206.81197 25492.08311 13318.89527 18377.97497 13713.31741 28904.3825 20395.58452 24744.54766 33371.79942 34134.18381 20445.16284 14469.6908 14541.6872 2-hydroxyisobutyric acid 2952.862803 22666.11991 15535.83323 10170.41477 6978.543662 10233.25462 8323.790542 25380.25437 47948.60886 38279.31664 3571.687583 11969.71617 5063.760297 2179.794855 7090.641083 3585.289801 3520.080425 3856.234874 3715.782167 1962.831232 2096.768924 2584.01197 1956.416414 2429.573324 16085.23832 54254.3929 288751.7939 40756.30399 24530.2907 9875.43014 17399.70095 11478.60464 13346.57311 12158.91259 7648.596336 7122.191358 31763.75377 19929.17938 92889.33492 8319.594694 8488.122059 6118.865777 23773.25756 1756.482726 4620.778085 5154.362056 3592.420434 2213.416751 3088.756157 10048.69688 5614.298918 9352.725361 5048.645561 3856.904703 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Retention Index Moverz Quant PubChem CID KEGG ID 2,6-diaminoheptanedioate 0.72 191.1026 5460662 C00666 L-Histidine 0.72 156.0768 6274 C00135 Glycine 0.74 76.0393 750 C00037 GABA 0.84 104.0706 119 C00334 L-Proline 0.92 116.0706 145742 C16435 N-acetyl-L-aspartic_Acid 1.6 176.0553 65065 CA1200 Pyridoxal 1.82 166.05093 1050 C00250 Isoleucine 2.26 132.1019 6306 C16439 Citramalate 2.45 171.0264 1081 C00815 Leucine 2.55 132.1019 6106 C00123 5-hydroxymethyl-2-furaldehyde 6.39 127.0388 237332 C11101 Kynurenine 6.4 209.09207 846 C01718 Serotonin 6.8 177.10224 5202 C00780 Xanthurenic Acid 7.5 206.04478 5699 C02470 Tryptophan 7.7 205.09715 6305 C00806 Kynurenic Acid 7.98 190.04987 3845 C01717 Anthranilic Acid 8.95 120.04439 227 C00108 Tauroursodeoxycholic acid 10.26 464.2816 9848818 C16868 Glucosamine/Mannosamine 11.94 180.0866 18897/440049 C00329/C00645 D-Galacturonic Acid 0.74 193.0354 439215 C00333 Methyl-β-D-galactoside 0.92 193.0718 94214 C03619 Uridine 2.83 243.0623 6029 C00299 Tyrosine 3.34 180.066 6057 C00082 Indoxyl Sulfate 8.13 212.0023 10258 L-Glutamine 0.72 145.0619 5961 C00064 Aspartate 0.71 132.032 5460294 C00049 Valine 1.09 116.0717 6287 C00183 2-hydroxyisobutyric acid 2.27 103.041 11671 C05984 METABOLITES_END #END