{ "METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001760","ANALYSIS_ID":"AN002867","VERSION":"1","CREATED_ON":"April 30, 2021, 5:12 pm"}, "PROJECT":{"PROJECT_SUMMARY":"This study aimed to optimize the detection of several key redox-reactive metabolites from mammalian cells and tissues. We explored three different chromatographic methods and optimized sample preparation, extraction buffer and conditions as well as mass spectrometry detection parameters. The established method was tested and validated using biologically relevant ROS-inducing conditions. This study can be a valuable resource for the metabolomics community.","INSTITUTE":"Boston Childrens Hospital","DEPARTMENT":"Pathology","LABORATORY":"Naama Kanarek","FIRST_NAME":"Boryana","ADDRESS":"300 Longwood Av, Boston, MA, 2115, USA","EMAIL":"boryana.petrova@childrens.harvard.edu","PHONE":"6173557433","PROJECT_TITLE":"Redox metabolism measurement in mammalian cells and tissues by quantitative LC/MS method (part II)","LAST_NAME":"Petrova"}, "STUDY":{"STUDY_TITLE":"Application of the redox metabolite detection method for mouse kidney","STUDY_SUMMARY":"This study was aimed at optimizing redox metabolites detection from mammalian tissues. Three different chromatographic conditions were compared as well as three different extraction conditions. This study was run on ZIC-pHILIC chromatography. This study is an independent replicate","INSTITUTE":"Boston Children's Hospital, Harvard Medical School","DEPARTMENT":"Pathology","LABORATORY":"Naama Kanarek","LAST_NAME":"Petrova","FIRST_NAME":"Boryana","ADDRESS":"300 Longwood Av, Boston, MA, 2115, USA","EMAIL":"boryana.petrova@childrens.harvard.edu","PHONE":"6173557433"}, "SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"}, "SUBJECT_SAMPLE_FACTORS":[ { "Subject ID":"-", "Sample ID":"A1- mouse A kidney in buffer B", "Factors":{"EXTRACTION BUFFER":"buffer B"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW130","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"B1- mouse B kidney in buffer B", "Factors":{"EXTRACTION BUFFER":"buffer B"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW131","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"C1- mouse C kidney in buffer B", "Factors":{"EXTRACTION BUFFER":"buffer B"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW132","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"D1- mouse D kidney in buffer B", "Factors":{"EXTRACTION BUFFER":"buffer B"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW133","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"A2- mouse A kidney in buffer C", "Factors":{"EXTRACTION BUFFER":"buffer C"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW134","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"B2- mouse B kidney in buffer C", "Factors":{"EXTRACTION BUFFER":"buffer C"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW135","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"C2- mouse C kidney in buffer C", "Factors":{"EXTRACTION BUFFER":"buffer C"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW136","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"D2- mouse D kidney in buffer C", "Factors":{"EXTRACTION BUFFER":"buffer C"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW137","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"A3- mouse A kidney in buffer C_Ellmans", "Factors":{"EXTRACTION BUFFER":"buffer C_Ellmans"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW138","DESCRIPTION":"much smaller pellet - reconstituted in 30ul","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"B3- mouse A kidney in buffer C_Ellmans", "Factors":{"EXTRACTION BUFFER":"buffer C_Ellmans"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW139","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"C3- mouse A kidney in buffer C_Ellmans", "Factors":{"EXTRACTION BUFFER":"buffer C_Ellmans"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW140","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"D3- mouse A lkidney in buffer C_Ellmans", "Factors":{"EXTRACTION BUFFER":"buffer C_Ellmans"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW141","DESCRIPTION":"liver chunk extracted in 300ul buffer, reconstituted in 100ul water","INTERNAL STANDARDS":"aminopterin, isotopically labelled amino acids, GSH-13C2-15N-13C2-15N","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"pooled sample QC a", "Factors":{"EXTRACTION BUFFER":"-"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW142_pool_1x","DESCRIPTION":"-","INTERNAL STANDARDS":"-","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"pooled sample QC b", "Factors":{"EXTRACTION BUFFER":"-"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW142_pool_1x_a","DESCRIPTION":"-","INTERNAL STANDARDS":"-","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"pooled sample QC c", "Factors":{"EXTRACTION BUFFER":"-"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW142_pool_1x_b","DESCRIPTION":"-","INTERNAL STANDARDS":"-","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"pooled sample QC 1/10 dilution", "Factors":{"EXTRACTION BUFFER":"-"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW143_pool_01x","DESCRIPTION":"-","INTERNAL STANDARDS":"-","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"pooled sample QC 1/10 dilution a", "Factors":{"EXTRACTION BUFFER":"-"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW143_pool_01x_a","DESCRIPTION":"-","INTERNAL STANDARDS":"-","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"pooled sample QC 1/3 dilution", "Factors":{"EXTRACTION BUFFER":"-"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW144_pool_03x","DESCRIPTION":"-","INTERNAL STANDARDS":"-","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"pooled sample QC 1/3 dilution a", "Factors":{"EXTRACTION BUFFER":"-"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_AW144_pool_03x_a","DESCRIPTION":"-","INTERNAL STANDARDS":"-","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"blank1", "Factors":{"EXTRACTION BUFFER":"-"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_blank_end1","DESCRIPTION":"-","INTERNAL STANDARDS":"-","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"blank2", "Factors":{"EXTRACTION BUFFER":"-"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_blank_end2","DESCRIPTION":"-","INTERNAL STANDARDS":"-","CHROMATOGRAPHY":"HILIC"} }, { "Subject ID":"-", "Sample ID":"blank3", "Factors":{"EXTRACTION BUFFER":"-"}, "Additional sample data":{"RAW_FILE_NAME":"20200716_QEF1_HILIC_mouse_kidney_blank1","DESCRIPTION":"-","INTERNAL STANDARDS":"-","CHROMATOGRAPHY":"HILIC"} } ], "COLLECTION":{"COLLECTION_SUMMARY":"All animal care and experimental procedures were approved by the Institutional Animal Care and Use Committees of Boston Children’s Hospital. Mouse strain used was C57BL/6. Pure CSF samples were collected from the cisterna magna [39]. Blood samples were collected from the retromandibular vein. The samples were coagulated and centrifuged. Liver and kidney were collected and flash frozen. Tissue chunks were cut on a glass plate while kept chilled on top of dry ice. K562 cells used in this manuscript were authenticated by short tandem repeat analysis and tested negative for mycoplasma. Cells were cultured in RPMI (Genesee Scientific) up to a density of 2 Million cells per ml. For redox chemical treatment experiments, cells were seeded at 1 Million cells per ml cell density in 6-well plates and drugs were added for 4h at the following concentrations: methotrexate: 5 µM; oligomycin: 80 µg/ml; H2O2: 1 mM; diamide: 0.5 mM; DMSO, which served as control: 0.6 µl per 1 mL of cell culture media (equivalent to volume used for oligomycin).","SAMPLE_TYPE":"Kidney"}, "TREATMENT":{"TREATMENT_SUMMARY":"buffer only"}, "SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Metabolites were quenched as quickly as possible while working with the samples at low temperatures. Cells were handled at 4ºC or on dry ice, extraction buffer was pre-chilled at -20ºC. Samples were analyzed by LC-MS on the same day of extraction (if impractical, best alternative is to store dried samples at -80ºC). Unless indicated otherwise, 1 million cells or about 2 mg of tissue was extracted per condition and a minimum of three replicates per condition was used in each experiment. K562 cells that are non-adherent, were collected by brief centrifugation at 4ºC using a table-top centrifuge (4,500 rpm, 1.5 min) and washed briefly in 0.9% NaCl (high grade salt and LC-MS-grade water Fisher Scientific W6500 or Sigma Aldrich 1.15333). 300 µl of prechilled extraction buffer were added per sample. For tissues – chunks were crushed using a hand-held homogenizer (VWR 47747-370) with several pulses while keeping the samples on ice. 300 µl of prechilled extraction buffer was used per 2 mg of tissue. Extraction buffer “A”: 40:40:20 of acetonitrile:methanol:water, supplemented with 0.1M formic acid and isotopically-labeled internal standards (17 amino acids and reduced glutathione, Cambridge Isotope Laboratories, MSK-A2-1.2 and CNLM-6245-10). Extraction buffer “B”: 80% LC-MS-grade methanol, 20% 25 mM Ammonium Acetate and 2.5 mM Na-Ascorbate prepared in LC-MS water and supplemented with isotopically labeled internal standards (17 amino acids and isotopically labelled reduced glutathione, Cambridge Isotope Laboratories, MSK-A2-1.2 and CNLM-6245-10). Extraction buffer “C” and “C + Ellman’s”: Solution 1: 100% LC-MS Methanol Solution 2: 25mM Ammonium Acetate and 2.5mM Na-Ascorbate in LC-MS water supplemented with isotopically labelled reduced glutathione and isotopically labeled internal standards (17 amino acids and reduced glutathione, Cambridge Isotope Laboratories, MSK-A2-1.2 and CNLM-6245-10). Ellman’s reagent (5,5′-Dithiobis(2-nitrobenzoic acid),D8130, Sigma Aldrich): 20 mM in “Solution 2”. Final composition is 80% solution 1 and 20% solution 2. Samples were vortexed briefly (10 sec) and sonicated for 3 min in a 4ºC water bath. Samples were then centrifuged for 10 min, 4ºC, at maximum speed on a benchtop centrifuge (Eppendorf) and the cleared supernatant was transferred to a new tube. Samples were dried using a nitrogen dryer while on ice, and special attention was given to minimize the time of drying and to not let samples idle in the dryer (Reacti-Vap™ Evaporator, Thermo Fisher Scientific, TS-18826) once the drying process was completed. Needles were continuously adjusted to the surface of the liquid as the samples evaporated to expedite the drying process. Samples were reconstituted in 30 µl LC-MS-grade water by brief sonication in a 4ºC water bath. Extracted metabolites were spun for 2 min at maximum speed on a bench-top centrifuge and cleared supernatant was transferred to LC-MS micro vials (National Scientific, C5000-45B). A small amount of each sample was pooled and serially diluted 3- and 10-fold to be used as quality controls throughout the run of each batch."}, "CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"ZIC-pHILIC chromatography: One ml of reconstituted sample was injected into a ZIC-pHILIC 150 × 2.1 mm (5 µm particle size) column (EMD Millipore) operated on a Vanquish™ Flex UHPLC Systems (Thermo Fisher Scientific, San Jose, CA). Chromatographic separation was achieved using the following conditions: buffer A was acetonitrile; buffer B was 20 mM ammonium carbonate, 0.1% ammonium hydroxide. Gradient conditions were: linear gradient from 20% to 80% B; 20–20.5 min: from 80% to 20% B; 20.5–28 min: hold at 20% B. The column oven and autosampler tray were held at 25 °C and 4 °C, respectively.","CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Thermo Vanquish","COLUMN_NAME":"EMD Millipore ZIC HILIC (150 x 2.1mm, 5um)"}, "ANALYSIS":{"ANALYSIS_TYPE":"MS"}, "MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"UNSPECIFIED","MS_COMMENTS":"HESI"}, "MS_METABOLITE_DATA":{ "Units":"ppm", "Data":[{"Metabolite":"1-methylnicotinamide_unc","A1- mouse A kidney in buffer B":"N/F","B1- mouse B kidney in buffer B":"N/F","C1- mouse C kidney in buffer B":"N/F","D1- mouse D kidney in buffer B":"N/F","A2- mouse A kidney in buffer C":"N/F","B2- mouse B kidney in buffer C":"N/F","C2- mouse C kidney in buffer C":"N/F","D2- mouse D kidney in buffer C":"N/F","A3- mouse A kidney in buffer C_Ellmans":"N/F","B3- mouse A kidney in buffer C_Ellmans":"N/F","C3- mouse A kidney in buffer C_Ellmans":"N/F","D3- mouse A lkidney in buffer C_Ellmans":"N/F","pooled sample QC a":"N/F","pooled sample QC b":"N/F","pooled sample QC c":"N/F","pooled sample QC 1/10 dilution":"N/F","pooled sample QC 1/10 dilution a":"N/F","pooled sample QC 1/3 dilution":"N/F","pooled sample QC 1/3 dilution a":"N/F","blank1":"N/F","blank2":"N/F","blank3":"N/F"},{"Metabolite":"2,3-BPG_unc","A1- mouse A kidney in buffer B":"403314","B1- mouse B kidney in buffer B":"182063","C1- mouse C kidney in buffer B":"472553","D1- mouse D kidney in buffer B":"481170","A2- mouse A kidney in buffer C":"2295950","B2- mouse B kidney in buffer C":"297211","C2- mouse C kidney in buffer C":"875582","D2- mouse D kidney in buffer C":"598824","A3- mouse A kidney in buffer C_Ellmans":"4988162","B3- mouse A kidney in buffer C_Ellmans":"2388913","C3- mouse A kidney in buffer C_Ellmans":"1847963","D3- mouse A lkidney in buffer C_Ellmans":"5424724","pooled sample QC a":"1503277","pooled sample QC b":"1858397","pooled sample QC c":"1741812","pooled sample QC 1/10 dilution":"552779","pooled sample QC 1/10 dilution a":"460668","pooled sample QC 1/3 dilution":"141979","pooled sample QC 1/3 dilution a":"111010","blank1":"N/F","blank2":"N/F","blank3":"N/F"},{"Metabolite":"2-aminoadipate","A1- mouse A kidney in buffer B":"15420402","B1- mouse B kidney in buffer B":"7394364","C1- mouse C kidney in buffer B":"7221941","D1- mouse D kidney in buffer B":"9651160","A2- mouse A kidney in buffer C":"N/F","B2- mouse B kidney in buffer C":"N/F","C2- mouse C kidney in buffer C":"8007882","D2- mouse D kidney in buffer C":"8063135","A3- mouse A kidney in buffer C_Ellmans":"20953605","B3- mouse A kidney in buffer C_Ellmans":"10826586","C3- mouse A kidney in buffer C_Ellmans":"7485928","D3- mouse A lkidney in buffer C_Ellmans":"13982649","pooled sample QC a":"11173922","pooled sample QC b":"10339950","pooled sample QC c":"9253269","pooled sample QC 1/10 dilution":"4446063","pooled sample QC 1/10 dilution a":"3325676","pooled sample QC 1/3 dilution":"1686832","pooled sample QC 1/3 dilution a":"1593947","blank1":"N/F","blank2":"N/F","blank3":"N/F"},{"Metabolite":"2-aminobutyric_acid","A1- mouse A kidney in buffer B":"N/F","B1- mouse B kidney in buffer B":"N/F","C1- mouse C kidney in buffer B":"N/F","D1- mouse D kidney in buffer B":"N/F","A2- mouse A kidney in buffer C":"N/F","B2- mouse B kidney in buffer C":"N/F","C2- mouse C kidney in buffer C":"N/F","D2- mouse D kidney in buffer C":"N/F","A3- mouse A kidney in buffer C_Ellmans":"N/F","B3- mouse A kidney in buffer C_Ellmans":"N/F","C3- mouse A kidney in buffer C_Ellmans":"N/F","D3- mouse A lkidney in buffer C_Ellmans":"N/F","pooled sample QC a":"N/F","pooled sample QC b":"N/F","pooled sample QC c":"N/F","pooled sample QC 1/10 dilution":"N/F","pooled sample QC 1/10 dilution a":"N/F","pooled sample QC 1/3 dilution":"N/F","pooled sample QC 1/3 dilution a":"N/F","blank1":"N/F","blank2":"N/F","blank3":"N/F"},{"Metabolite":"2-hydroxybutyric_acid","A1- mouse A kidney in buffer B":"24651778","B1- mouse B kidney in buffer B":"20173132","C1- mouse C kidney in buffer B":"6443894","D1- mouse D kidney in buffer B":"9990887","A2- mouse A kidney in buffer C":"13713251","B2- mouse B kidney in buffer C":"29800179","C2- mouse C kidney in buffer C":"14103593","D2- mouse D kidney in buffer C":"17153487","A3- mouse A kidney in buffer C_Ellmans":"N/F","B3- mouse A kidney in buffer C_Ellmans":"7436495","C3- mouse A kidney in buffer C_Ellmans":"N/F","D3- mouse A lkidney in buffer C_Ellmans":"N/F","pooled sample QC a":"7449590","pooled sample QC b":"N/F","pooled sample QC c":"7773575","pooled sample QC 1/10 dilution":"2899559","pooled sample QC 1/10 dilution a":"2498093","pooled sample QC 1/3 dilution":"1302711","pooled sample QC 1/3 dilution a":"1557887","blank1":"N/F","blank2":"N/F","blank3":"N/F"},{"Metabolite":"2-hydroxyglutarate","A1- mouse A kidney in buffer B":"57298801","B1- mouse B kidney in buffer B":"60077035","C1- mouse C kidney in buffer B":"30740914","D1- mouse D kidney in buffer B":"34826367","A2- mouse A kidney in buffer C":"85481635","B2- mouse B kidney in buffer C":"183018399","C2- mouse C kidney in buffer C":"256757630","D2- mouse D kidney in buffer C":"261487454","A3- mouse A kidney in buffer C_Ellmans":"200236414","B3- mouse A kidney in buffer C_Ellmans":"211813072","C3- mouse A kidney in buffer C_Ellmans":"208321436","D3- mouse A lkidney in buffer C_Ellmans":"222968510","pooled sample QC a":"135799909","pooled sample QC b":"177325095","pooled sample QC c":"169340690","pooled sample QC 1/10 dilution":"70682312","pooled sample QC 1/10 dilution a":"93762965","pooled sample QC 1/3 dilution":"32264918","pooled sample QC 1/3 dilution a":"48979981","blank1":"N/F","blank2":"N/F","blank3":"N/F"},{"Metabolite":"2-oxoadipate_unc","A1- mouse A kidney in buffer B":"N/F","B1- mouse B kidney in buffer B":"N/F","C1- mouse C kidney in buffer B":"N/F","D1- mouse D kidney in buffer B":"N/F","A2- mouse A kidney in buffer C":"N/F","B2- mouse B kidney in buffer C":"843704","C2- mouse C kidney in buffer C":"606552","D2- mouse D kidney in buffer C":"N/F","A3- mouse A kidney in buffer C_Ellmans":"N/F","B3- mouse A kidney in buffer C_Ellmans":"566096","C3- mouse A kidney in buffer C_Ellmans":"N/F","D3- mouse A lkidney in buffer C_Ellmans":"N/F","pooled sample QC a":"288268","pooled sample QC b":"378548","pooled sample QC c":"552255","pooled sample QC 1/10 dilution":"N/F","pooled sample QC 1/10 dilution a":"N/F","pooled sample QC 1/3 dilution":"N/F","pooled sample QC 1/3 dilution a":"N/F","blank1":"N/F","blank2":"N/F","blank3":"N/F"},{"Metabolite":"2-oxobutyric_acid","A1- mouse A kidney in buffer B":"N/F","B1- mouse B kidney in buffer B":"N/F","C1- mouse C kidney in buffer B":"N/F","D1- mouse D kidney in buffer B":"N/F","A2- mouse A kidney in buffer C":"N/F","B2- mouse B kidney in buffer C":"N/F","C2- mouse C kidney in buffer C":"N/F","D2- mouse D kidney in buffer C":"N/F","A3- mouse A kidney in buffer C_Ellmans":"N/F","B3- mouse A kidney in buffer C_Ellmans":"N/F","C3- mouse A kidney in buffer C_Ellmans":"N/F","D3- mouse A lkidney in buffer C_Ellmans":"N/F","pooled sample QC a":"N/F","pooled sample QC b":"N/F","pooled sample QC c":"N/F","pooled sample QC 1/10 dilution":"N/F","pooled sample QC 1/10 dilution a":"N/F","pooled sample QC 1/3 dilution":"N/F","pooled sample QC 1/3 dilution a":"N/F","blank1":"N/F","blank2":"N/F","blank3":"N/F"},{"Metabolite":"3-hydroxybutyrate","A1- mouse A kidney in buffer B":"30356150","B1- mouse B kidney in buffer B":"39848900","C1- mouse C kidney in buffer B":"15475861","D1- mouse D kidney in buffer B":"34819912","A2- mouse A kidney in buffer C":"15078216","B2- mouse B kidney in buffer C":"62653473","C2- mouse C kidney in buffer C":"32293899","D2- mouse D kidney in buffer C":"59962620","A3- mouse A kidney in buffer C_Ellmans":"5687471","B3- mouse A kidney in buffer C_Ellmans":"47288635","C3- mouse A kidney in buffer C_Ellmans":"22971904","D3- mouse A lkidney in buffer C_Ellmans":"93067343","pooled sample QC a":"44755539","pooled sample QC b":"39875329","pooled sample QC c":"39821708","pooled sample QC 1/10 dilution":"16206561","pooled sample QC 1/10 dilution a":"13832316","pooled sample QC 1/3 dilution":"5386811","pooled sample QC 1/3 dilution a":"4728203","blank1":"N/F","blank2":"N/F","blank3":"N/F"},{"Metabolite":"3-methyl-2-oxobutyrate","A1- mouse A kidney in buffer B":"N/F","B1- mouse B kidney in buffer B":"N/F","C1- mouse C kidney in buffer B":"N/F","D1- mouse D kidney in buffer B":"N/F","A2- mouse A kidney in buffer C":"N/F","B2- mouse B kidney in buffer C":"N/F","C2- mouse C kidney in buffer C":"N/F","D2- mouse D kidney in buffer C":"N/F","A3- mouse A kidney in buffer C_Ellmans":"N/F","B3- mouse A kidney in buffer C_Ellmans":"N/F","C3- mouse A kidney in buffer C_Ellmans":"N/F","D3- mouse A lkidney in buffer C_Ellmans":"N/F","pooled sample QC a":"N/F","pooled sample QC b":"N/F","pooled sample QC c":"N/F","pooled sample QC 1/10 dilution":"N/F","pooled sample QC 1/10 dilution a":"N/F","pooled sample QC 1/3 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