{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001822","ANALYSIS_ID":"AN002958","VERSION":"1","CREATED_ON":"June 7, 2021, 6:23 am"},

"PROJECT":{"PROJECT_TITLE":"The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective Trypanosoma brucei","PROJECT_SUMMARY":"Metabolic changes following two days of RBP42 knockdown was investigated using a targeted metabolomics approach, designed to capture intermediary metabolites in central carbon metabolism including glycolytic intermediates, TCA compounds, amino acids, nucleotides and derivatives, were obtained using hydrophilic interaction liquid chromatography (HILIC) separation method coupled with mass spectrometry run in negative ionization mode.","INSTITUTE":"Rutgers University","LAST_NAME":"Das","FIRST_NAME":"Anish","ADDRESS":"Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, NJ 07103","EMAIL":"dasak@njms.rutgers.edu","PHONE":"9739723978"},

"STUDY":{"STUDY_TITLE":"The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective Trypanosoma brucei","STUDY_SUMMARY":"Metabolic changes following two days of RBP42 knockdown was investigated using a targeted metabolomics approach, designed to capture intermediary metabolites in central carbon metabolism including glycolytic intermediates, TCA compounds, amino acids, nucleotides and derivatives, were obtained using hydrophilic interaction liquid chromatography (HILIC) separation method coupled with mass spectrometry run in negative ionization mode","INSTITUTE":"Rutgers University","LAST_NAME":"Das","FIRST_NAME":"Anish","ADDRESS":"Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, NJ 07103","EMAIL":"dasak@njms.rutgers.edu","PHONE":"9739723978"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Trypanosoma brucei brucei","TAXONOMY_ID":"5702","GENOTYPE_STRAIN":"427"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"RBP42_KD_1",
"Factors":{"Treatment":"Knockdown"},
"Additional sample data":{"RAW_FILE_NAME":"RBP42_KD_1.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"RBP42_KD_2",
"Factors":{"Treatment":"Knockdown"},
"Additional sample data":{"RAW_FILE_NAME":"RBP42_KD_2.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"RBP42_KD_3",
"Factors":{"Treatment":"Knockdown"},
"Additional sample data":{"RAW_FILE_NAME":"RBP42_KD_3.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"RBP42_KD_4",
"Factors":{"Treatment":"Knockdown"},
"Additional sample data":{"RAW_FILE_NAME":"RBP42_KD_4.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"RBP42_WT_1",
"Factors":{"Treatment":"Wild-type"},
"Additional sample data":{"RAW_FILE_NAME":"RBP42_WT_1.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"RBP42_WT_2",
"Factors":{"Treatment":"Wild-type"},
"Additional sample data":{"RAW_FILE_NAME":"RBP42_WT_2.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"RBP42_WT_3",
"Factors":{"Treatment":"Wild-type"},
"Additional sample data":{"RAW_FILE_NAME":"RBP42_WT_3.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"RBP42_WT_4",
"Factors":{"Treatment":"Wild-type"},
"Additional sample data":{"RAW_FILE_NAME":"RBP42_WT_4.mzXML"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"T. brucei Lister 427 bloodstream form RBP42 conditional knockdown cell line (RBP42Ty1) was grown in HMI-9 medium supplemented with 10% fetal bovine serum and 10% serum plus at 37C in a humidified incubator containing 5% CO2. Cultures were seeded at 1 x 10^5 cells/ml, passaged every 2-3 days and grown to a maximum of 1x10^6 cells per ml.","SAMPLE_TYPE":"Cultured cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"For metabolomic analysis, RBP42Ty1 cells were collected before and after two days of RBP42 depletion. Cells (2 x 10^7 cells/assay) were harvested and metabolites were extracted."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Metabolites were extracted with 1 ml of 40:40:20 mixture of methanol:acetonitrile:water plus 0.5% (V/V) formic acid on ice for 5 min. Following neutralization of formic acid by addition of 50 ul of 15% (m/V) NH4HCO3, cleared extracts were collected by centrifugation at 15000g for 10 min and stored at -80C."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"HILIC separation was performed on a Vanquish Horizon UHPLC system (Thermo Fisher Scientific, Waltham, MA) with an XBridge BEH Amide column (150 mm × 2.1 mm, 2.5 μm particle size, Waters, Milford, MA) using a gradient of solvent A (95%:5% H2O:acetonitrile with 20 mM acetic acid, 40 mM ammonium hydroxide, pH 9.4) and solvent B (20%:80% H2O:acetonitrile with 20 mM acetic acid, 40 mM ammonium hydroxide, pH 9.4). The gradient was 0 min, 100% B; 3 min, 100% B; 3.2 min, 90% B; 6.2 min, 90% B; 6.5 min, 80% B; 10.5 min, 80% B; 10.7 min, 70% B; 13.5 min, 70% B; 13.7 min, 45% B; 16 min, 45% B; 16.5 min, 100% B; and 22 min, 100% B. The flow rate was 300 μl/min. The injection volume was 5 μL, and the column temperature was set to 25°C. The autosampler temperature was set to 4°C, and the injection volume was 5 µL.","CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Thermo Vanquish","COLUMN_NAME":"Waters Acquity BEH Amide (150 x 2.1mm, 1.7um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Plus Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"NEGATIVE","MS_COMMENTS":"Each sample was analyzed with a nominal resolution of 70,000. The automatic gain control target was 3×106. The maximum injection time was 50 ms. Scan range was 75-1,000. The targeted metabolite data analysis was performed in MAVEN. The compound identification was based on the accurate mass and the retention time learned from in-house chemical collection"},

"MS_METABOLITE_DATA":{
"Units":"arbitrary",

"Data":[{"Metabolite":"GTP","RBP42_WT_1":"12222.91","RBP42_WT_2":"13064.98","RBP42_WT_3":"10953.71","RBP42_WT_4":"12151.38","RBP42_KD_1":"10899.07","RBP42_KD_2":"8328.846","RBP42_KD_3":"6834.805","RBP42_KD_4":"7292.322"},{"Metabolite":"UTP","RBP42_WT_1":"25369.22","RBP42_WT_2":"23201.37","RBP42_WT_3":"27254.85","RBP42_WT_4":"25879.84","RBP42_KD_1":"13539.65","RBP42_KD_2":"9998.15","RBP42_KD_3":"18785.42","RBP42_KD_4":"16546.94"},{"Metabolite":"Fructose-1 6-bisphosphate","RBP42_WT_1":"57444.69","RBP42_WT_2":"49922.18","RBP42_WT_3":"40830.83","RBP42_WT_4":"40174.78","RBP42_KD_1":"25098.07","RBP42_KD_2":"21793.85","RBP42_KD_3":"21223.55","RBP42_KD_4":"15316.85"},{"Metabolite":"Thiamine pyrophosphate","RBP42_WT_1":"3925.944","RBP42_WT_2":"4499.278","RBP42_WT_3":"2885.287","RBP42_WT_4":"1346.545","RBP42_KD_1":"1595.572","RBP42_KD_2":"1206.939","RBP42_KD_3":"829.0129","RBP42_KD_4":"987.8527"},{"Metabolite":"ATP","RBP42_WT_1":"121245.7","RBP42_WT_2":"105419.5","RBP42_WT_3":"122703.9","RBP42_WT_4":"95351.25","RBP42_KD_1":"79692.84","RBP42_KD_2":"60516","RBP42_KD_3":"69621.13","RBP42_KD_4":"75298.09"},{"Metabolite":"Lysine","RBP42_WT_1":"4982784","RBP42_WT_2":"7385096","RBP42_WT_3":"4325626","RBP42_WT_4":"4227810","RBP42_KD_1":"7964018","RBP42_KD_2":"6030420","RBP42_KD_3":"4376668","RBP42_KD_4":"4505898"},{"Metabolite":"NADP+","RBP42_WT_1":"3863.721","RBP42_WT_2":"6354.941","RBP42_WT_3":"4305.342","RBP42_WT_4":"5823.904","RBP42_KD_1":"876.6451","RBP42_KD_2":"780.7767","RBP42_KD_3":"0","RBP42_KD_4":"1247.039"},{"Metabolite":"Citrate","RBP42_WT_1":"139280","RBP42_WT_2":"227173.4","RBP42_WT_3":"133500.2","RBP42_WT_4":"117715.7","RBP42_KD_1":"258642.7","RBP42_KD_2":"175882.7","RBP42_KD_3":"129274.9","RBP42_KD_4":"154640.4"},{"Metabolite":"Arginine","RBP42_WT_1":"2903843","RBP42_WT_2":"4006551","RBP42_WT_3":"2728691","RBP42_WT_4":"2553868","RBP42_KD_1":"4124895","RBP42_KD_2":"3173367","RBP42_KD_3":"2378299","RBP42_KD_4":"2604921"},{"Metabolite":"Ornithine","RBP42_WT_1":"503273.9","RBP42_WT_2":"667685.7","RBP42_WT_3":"500428.8","RBP42_WT_4":"428277.8","RBP42_KD_1":"681605.7","RBP42_KD_2":"509261.2","RBP42_KD_3":"459931.8","RBP42_KD_4":"453612.8"},{"Metabolite":"Glucose-6-phosphate","RBP42_WT_1":"1217612","RBP42_WT_2":"1106084","RBP42_WT_3":"1047411","RBP42_WT_4":"995284.5","RBP42_KD_1":"1376615","RBP42_KD_2":"949872.5","RBP42_KD_3":"999239.8","RBP42_KD_4":"1013246"},{"Metabolite":"Phosphocholine (+HAc)","RBP42_WT_1":"1198495","RBP42_WT_2":"1139701","RBP42_WT_3":"1073472","RBP42_WT_4":"956525.8","RBP42_KD_1":"740284.3","RBP42_KD_2":"571426.5","RBP42_KD_3":"622360.1","RBP42_KD_4":"554436.6"},{"Metabolite":"ADP","RBP42_WT_1":"252503.1","RBP42_WT_2":"209117.4","RBP42_WT_3":"214665.2","RBP42_WT_4":"182544.5","RBP42_KD_1":"118954.9","RBP42_KD_2":"86932.72","RBP42_KD_3":"127250.6","RBP42_KD_4":"100538.4"},{"Metabolite":"Isocitrate","RBP42_WT_1":"12697.66","RBP42_WT_2":"24046.34","RBP42_WT_3":"16568.24","RBP42_WT_4":"13824.42","RBP42_KD_1":"27856.06","RBP42_KD_2":"21838.03","RBP42_KD_3":"15648.23","RBP42_KD_4":"16279.38"},{"Metabolite":"GMP","RBP42_WT_1":"17313.54","RBP42_WT_2":"17236.69","RBP42_WT_3":"17977.22","RBP42_WT_4":"13595.55","RBP42_KD_1":"11568.37","RBP42_KD_2":"8313.132","RBP42_KD_3":"10336.72","RBP42_KD_4":"8172.439"},{"Metabolite":"D-glucosamine-1 6-phosphate","RBP42_WT_1":"28404.12","RBP42_WT_2":"27448.99","RBP42_WT_3":"21805.59","RBP42_WT_4":"20938.22","RBP42_KD_1":"26664.26","RBP42_KD_2":"19145.73","RBP42_KD_3":"25278.28","RBP42_KD_4":"18685.49"},{"Metabolite":"CMP","RBP42_WT_1":"5805.061","RBP42_WT_2":"4756.084","RBP42_WT_3":"5706.655","RBP42_WT_4":"5540.932","RBP42_KD_1":"1256.782","RBP42_KD_2":"2529.156","RBP42_KD_3":"3543.355","RBP42_KD_4":"1331.268"},{"Metabolite":"Fructose-6-phosphate","RBP42_WT_1":"457864.1","RBP42_WT_2":"399711","RBP42_WT_3":"344998.2","RBP42_WT_4":"333562.1","RBP42_KD_1":"438763.8","RBP42_KD_2":"308984.2","RBP42_KD_3":"355363.9","RBP42_KD_4":"328880.7"},{"Metabolite":"D-erythrose-4-phosphate","RBP42_WT_1":"7019.135","RBP42_WT_2":"10992.27","RBP42_WT_3":"6326.312","RBP42_WT_4":"7498.891","RBP42_KD_1":"11961.37","RBP42_KD_2":"5796.074","RBP42_KD_3":"7746.199","RBP42_KD_4":"6110.965"},{"Metabolite":"NG-dimethyl-L-arginine","RBP42_WT_1":"5913.297","RBP42_WT_2":"9200.663","RBP42_WT_3":"4385.201","RBP42_WT_4":"1752.795","RBP42_KD_1":"8298.375","RBP42_KD_2":"6056.595","RBP42_KD_3":"6822.424","RBP42_KD_4":"4222.093"},{"Metabolite":"S-adenosyl-L-methionine","RBP42_WT_1":"6614.566","RBP42_WT_2":"10064.58","RBP42_WT_3":"7127.533","RBP42_WT_4":"9544.022","RBP42_KD_1":"3382.071","RBP42_KD_2":"1442.484","RBP42_KD_3":"1370.745","RBP42_KD_4":"1995.618"},{"Metabolite":"Aconitate","RBP42_WT_1":"110624.5","RBP42_WT_2":"146461.5","RBP42_WT_3":"99157.62","RBP42_WT_4":"82848.21","RBP42_KD_1":"144302.9","RBP42_KD_2":"111863.3","RBP42_KD_3":"99474.91","RBP42_KD_4":"96348.53"},{"Metabolite":"UDP-D-Glucose","RBP42_WT_1":"569654.8","RBP42_WT_2":"466188.6","RBP42_WT_3":"529500.6","RBP42_WT_4":"432908","RBP42_KD_1":"456773.7","RBP42_KD_2":"349137.9","RBP42_KD_3":"471837.1","RBP42_KD_4":"448897.6"},{"Metabolite":"Cystathionine","RBP42_WT_1":"43422.18","RBP42_WT_2":"47934.02","RBP42_WT_3":"65496.81","RBP42_WT_4":"52473.11","RBP42_KD_1":"19347.59","RBP42_KD_2":"17144.6","RBP42_KD_3":"22230.84","RBP42_KD_4":"21397.96"},{"Metabolite":"CDP-Choline (+HAc)","RBP42_WT_1":"20807.04","RBP42_WT_2":"15894.28","RBP42_WT_3":"16345.62","RBP42_WT_4":"12791.52","RBP42_KD_1":"7828.686","RBP42_KD_2":"6313.038","RBP42_KD_3":"7892.088","RBP42_KD_4":"7784.779"},{"Metabolite":"UMP","RBP42_WT_1":"149424.9","RBP42_WT_2":"167334.4","RBP42_WT_3":"159443.8","RBP42_WT_4":"149219.4","RBP42_KD_1":"64256.05","RBP42_KD_2":"56921.86","RBP42_KD_3":"94577.43","RBP42_KD_4":"76783.88"},{"Metabolite":"Ribose phosphate","RBP42_WT_1":"236709.4","RBP42_WT_2":"202256.6","RBP42_WT_3":"217086.7","RBP42_WT_4":"180404.1","RBP42_KD_1":"86812.3","RBP42_KD_2":"67291.86","RBP42_KD_3":"107511.5","RBP42_KD_4":"77400.23"},{"Metabolite":"NAD+","RBP42_WT_1":"126351.8","RBP42_WT_2":"112505.8","RBP42_WT_3":"119284","RBP42_WT_4":"104335.2","RBP42_KD_1":"59971.79","RBP42_KD_2":"54857.55","RBP42_KD_3":"71423.73","RBP42_KD_4":"67679.42"},{"Metabolite":"Folate","RBP42_WT_1":"121438.4","RBP42_WT_2":"177388.8","RBP42_WT_3":"107836.5","RBP42_WT_4":"112534.8","RBP42_KD_1":"177161","RBP42_KD_2":"138486.7","RBP42_KD_3":"90424.31","RBP42_KD_4":"100566.8"},{"Metabolite":"UDP-N-acetyl-glucosamine","RBP42_WT_1":"116958.5","RBP42_WT_2":"84790.35","RBP42_WT_3":"125880.2","RBP42_WT_4":"101534.7","RBP42_KD_1":"97360.32","RBP42_KD_2":"68105.21","RBP42_KD_3":"93830.18","RBP42_KD_4":"67401.91"},{"Metabolite":"Dihydroxyacetone phosphate","RBP42_WT_1":"114063.3","RBP42_WT_2":"92611.91","RBP42_WT_3":"97431.71","RBP42_WT_4":"77022.7","RBP42_KD_1":"66692.83","RBP42_KD_2":"58729.2","RBP42_KD_3":"45140.75","RBP42_KD_4":"59073.32"},{"Metabolite":"Glycerol-3-phosphate","RBP42_WT_1":"7795268","RBP42_WT_2":"6947658","RBP42_WT_3":"6325724","RBP42_WT_4":"5389911","RBP42_KD_1":"3842234","RBP42_KD_2":"3124696","RBP42_KD_3":"4178787","RBP42_KD_4":"3341963"},{"Metabolite":"Coenzyme A","RBP42_WT_1":"22945.7","RBP42_WT_2":"11400.84","RBP42_WT_3":"22002.93","RBP42_WT_4":"19754.37","RBP42_KD_1":"7487.994","RBP42_KD_2":"5009.983","RBP42_KD_3":"10836.36","RBP42_KD_4":"3934.454"},{"Metabolite":"Cystine","RBP42_WT_1":"2029556","RBP42_WT_2":"3222874","RBP42_WT_3":"1939202","RBP42_WT_4":"1770658","RBP42_KD_1":"3393200","RBP42_KD_2":"2568142","RBP42_KD_3":"1774317","RBP42_KD_4":"1919503"},{"Metabolite":"AMP","RBP42_WT_1":"312294","RBP42_WT_2":"369574.1","RBP42_WT_3":"314445.2","RBP42_WT_4":"313732","RBP42_KD_1":"190204.5","RBP42_KD_2":"239497.8","RBP42_KD_3":"272481.1","RBP42_KD_4":"195031.8"},{"Metabolite":"Acetyl CoA","RBP42_WT_1":"15021.07","RBP42_WT_2":"20231.18","RBP42_WT_3":"22817.29","RBP42_WT_4":"9061.144","RBP42_KD_1":"16343.72","RBP42_KD_2":"14350.54","RBP42_KD_3":"17886.51","RBP42_KD_4":"13629.33"},{"Metabolite":"Malate","RBP42_WT_1":"4213098","RBP42_WT_2":"4952305","RBP42_WT_3":"3808662","RBP42_WT_4":"3214329","RBP42_KD_1":"3584550","RBP42_KD_2":"2481703","RBP42_KD_3":"2054221","RBP42_KD_4":"2388351"},{"Metabolite":"Carnosine","RBP42_WT_1":"93352.98","RBP42_WT_2":"119142.4","RBP42_WT_3":"78983.24","RBP42_WT_4":"83937.01","RBP42_KD_1":"116509.2","RBP42_KD_2":"95354.55","RBP42_KD_3":"82329.92","RBP42_KD_4":"82605.07"},{"Metabolite":"Aminoadipic acid","RBP42_WT_1":"30024.63","RBP42_WT_2":"35648.3","RBP42_WT_3":"27675.47","RBP42_WT_4":"25282.05","RBP42_KD_1":"40052.93","RBP42_KD_2":"35792.97","RBP42_KD_3":"27504.94","RBP42_KD_4":"32327.12"},{"Metabolite":"Glutathione","RBP42_WT_1":"32339.92","RBP42_WT_2":"40119.43","RBP42_WT_3":"29691.47","RBP42_WT_4":"32653.28","RBP42_KD_1":"35605.11","RBP42_KD_2":"35154.32","RBP42_KD_3":"36711.62","RBP42_KD_4":"35939.65"},{"Metabolite":"Aspartate","RBP42_WT_1":"3229949","RBP42_WT_2":"5300042","RBP42_WT_3":"2830144","RBP42_WT_4":"2637400","RBP42_KD_1":"5302538","RBP42_KD_2":"3788934","RBP42_KD_3":"2264893","RBP42_KD_4":"2785946"},{"Metabolite":"Glutamate","RBP42_WT_1":"1.08E+07","RBP42_WT_2":"1.59E+07","RBP42_WT_3":"8770479","RBP42_WT_4":"8605992","RBP42_KD_1":"2.07E+07","RBP42_KD_2":"1.45E+07","RBP42_KD_3":"1.20E+07","RBP42_KD_4":"1.21E+07"},{"Metabolite":"N-Acetylaspartate","RBP42_WT_1":"17456.31","RBP42_WT_2":"20400.05","RBP42_WT_3":"10184.46","RBP42_WT_4":"12035.99","RBP42_KD_1":"24393.03","RBP42_KD_2":"16029.79","RBP42_KD_3":"13571.77","RBP42_KD_4":"15018.18"},{"Metabolite":"2-Hydroxyglutarate","RBP42_WT_1":"7989554","RBP42_WT_2":"8830917","RBP42_WT_3":"7076924","RBP42_WT_4":"6649860","RBP42_KD_1":"7453088","RBP42_KD_2":"6762334","RBP42_KD_3":"7011754","RBP42_KD_4":"7044144"},{"Metabolite":"Glucuronic acid","RBP42_WT_1":"49810.4","RBP42_WT_2":"74792.97","RBP42_WT_3":"54938.49","RBP42_WT_4":"50238.27","RBP42_KD_1":"84367.77","RBP42_KD_2":"58922.14","RBP42_KD_3":"53793.84","RBP42_KD_4":"57004.54"},{"Metabolite":"Succinate","RBP42_WT_1":"7.11E+07","RBP42_WT_2":"6.84E+07","RBP42_WT_3":"6.55E+07","RBP42_WT_4":"6.23E+07","RBP42_KD_1":"3.68E+07","RBP42_KD_2":"2.93E+07","RBP42_KD_3":"2.97E+07","RBP42_KD_4":"2.90E+07"},{"Metabolite":"N-acetyl-glutamate","RBP42_WT_1":"10583.3","RBP42_WT_2":"12527.33","RBP42_WT_3":"5781.428","RBP42_WT_4":"5862.978","RBP42_KD_1":"11613.71","RBP42_KD_2":"6635.783","RBP42_KD_3":"6977.483","RBP42_KD_4":"6533.34"},{"Metabolite":"Inositol","RBP42_WT_1":"1868794","RBP42_WT_2":"2502380","RBP42_WT_3":"1633381","RBP42_WT_4":"1599725","RBP42_KD_1":"2526845","RBP42_KD_2":"2026161","RBP42_KD_3":"1603090","RBP42_KD_4":"1711163"},{"Metabolite":"Methylsuccinic acid","RBP42_WT_1":"497220.2","RBP42_WT_2":"535595.8","RBP42_WT_3":"503771.7","RBP42_WT_4":"429843.3","RBP42_KD_1":"464894.4","RBP42_KD_2":"380956.1","RBP42_KD_3":"398090","RBP42_KD_4":"415821.8"},{"Metabolite":"Glycerophosphocholine (+HAc)","RBP42_WT_1":"1.57E+07","RBP42_WT_2":"1.38E+07","RBP42_WT_3":"1.36E+07","RBP42_WT_4":"1.21E+07","RBP42_KD_1":"9293693","RBP42_KD_2":"7691088","RBP42_KD_3":"8632653","RBP42_KD_4":"7835234"},{"Metabolite":"Oxaloacetate","RBP42_WT_1":"6164.096","RBP42_WT_2":"8639.187","RBP42_WT_3":"5245.624","RBP42_WT_4":"1975.248","RBP42_KD_1":"4940.588","RBP42_KD_2":"1965.517","RBP42_KD_3":"3082.217","RBP42_KD_4":"2874.244"},{"Metabolite":"a-ketoglutarate","RBP42_WT_1":"1516307","RBP42_WT_2":"2147187","RBP42_WT_3":"1577918","RBP42_WT_4":"1443166","RBP42_KD_1":"3856420","RBP42_KD_2":"3987198","RBP42_KD_3":"3302137","RBP42_KD_4":"2939210"},{"Metabolite":"Homocitrulline","RBP42_WT_1":"4355.798","RBP42_WT_2":"6652.811","RBP42_WT_3":"6056.293","RBP42_WT_4":"5636.865","RBP42_KD_1":"8298.796","RBP42_KD_2":"7794.831","RBP42_KD_3":"4144.242","RBP42_KD_4":"5053.826"},{"Metabolite":"Asparagine","RBP42_WT_1":"3887336","RBP42_WT_2":"4948009","RBP42_WT_3":"3460186","RBP42_WT_4":"3019354","RBP42_KD_1":"4757176","RBP42_KD_2":"3429890","RBP42_KD_3":"2863299","RBP42_KD_4":"2782347"},{"Metabolite":"Serine","RBP42_WT_1":"9735769","RBP42_WT_2":"1.17E+07","RBP42_WT_3":"8811733","RBP42_WT_4":"7691286","RBP42_KD_1":"1.09E+07","RBP42_KD_2":"8199488","RBP42_KD_3":"7182162","RBP42_KD_4":"7063338"},{"Metabolite":"Glutamine","RBP42_WT_1":"5.84E+07","RBP42_WT_2":"8.43E+07","RBP42_WT_3":"5.36E+07","RBP42_WT_4":"5.08E+07","RBP42_KD_1":"7.92E+07","RBP42_KD_2":"6.55E+07","RBP42_KD_3":"4.68E+07","RBP42_KD_4":"5.06E+07"},{"Metabolite":"Hisidine","RBP42_WT_1":"4145031","RBP42_WT_2":"5142443","RBP42_WT_3":"3811649","RBP42_WT_4":"3197936","RBP42_KD_1":"3940015","RBP42_KD_2":"2521285","RBP42_KD_3":"2187809","RBP42_KD_4":"2103264"},{"Metabolite":"1-Methylhistidine","RBP42_WT_1":"31879.83","RBP42_WT_2":"45571.67","RBP42_WT_3":"32091.45","RBP42_WT_4":"34309.63","RBP42_KD_1":"51002.15","RBP42_KD_2":"33846.05","RBP42_KD_3":"31251.73","RBP42_KD_4":"31929.1"},{"Metabolite":"Shikimate","RBP42_WT_1":"124562.6","RBP42_WT_2":"159315.9","RBP42_WT_3":"138558.1","RBP42_WT_4":"130586.7","RBP42_KD_1":"161535.5","RBP42_KD_2":"124668.5","RBP42_KD_3":"137164.1","RBP42_KD_4":"126008.6"},{"Metabolite":"Methionine sulfoxide","RBP42_WT_1":"30010.05","RBP42_WT_2":"35956.94","RBP42_WT_3":"22651.91","RBP42_WT_4":"17217.55","RBP42_KD_1":"45941.03","RBP42_KD_2":"28989.38","RBP42_KD_3":"19697.9","RBP42_KD_4":"21472.61"},{"Metabolite":"Glycine","RBP42_WT_1":"1319209","RBP42_WT_2":"1656321","RBP42_WT_3":"1295202","RBP42_WT_4":"1157357","RBP42_KD_1":"1526534","RBP42_KD_2":"1152698","RBP42_KD_3":"1075352","RBP42_KD_4":"1069920"},{"Metabolite":"Threonine","RBP42_WT_1":"1.04E+07","RBP42_WT_2":"1.79E+07","RBP42_WT_3":"8369434","RBP42_WT_4":"7776822","RBP42_KD_1":"1.60E+07","RBP42_KD_2":"1.01E+07","RBP42_KD_3":"6649126","RBP42_KD_4":"7052088"},{"Metabolite":"Alanine","RBP42_WT_1":"9166037","RBP42_WT_2":"9051575","RBP42_WT_3":"8745685","RBP42_WT_4":"8242276","RBP42_KD_1":"6167882","RBP42_KD_2":"5235864","RBP42_KD_3":"6083526","RBP42_KD_4":"5691556"},{"Metabolite":"Threonic acid","RBP42_WT_1":"1786427","RBP42_WT_2":"2205308","RBP42_WT_3":"1769120","RBP42_WT_4":"1636220","RBP42_KD_1":"2515443","RBP42_KD_2":"2114169","RBP42_KD_3":"1688692","RBP42_KD_4":"1619997"},{"Metabolite":"Hydroxyproline","RBP42_WT_1":"134480.5","RBP42_WT_2":"122016","RBP42_WT_3":"160552","RBP42_WT_4":"139486.9","RBP42_KD_1":"125432.8","RBP42_KD_2":"118272.9","RBP42_KD_3":"98819.65","RBP42_KD_4":"105324.2"},{"Metabolite":"Creatine","RBP42_WT_1":"26421.58","RBP42_WT_2":"17232","RBP42_WT_3":"28778.47","RBP42_WT_4":"13044.12","RBP42_KD_1":"38497.88","RBP42_KD_2":"12314.83","RBP42_KD_3":"10949.95","RBP42_KD_4":"24740.33"},{"Metabolite":"Uric acid","RBP42_WT_1":"466247.6","RBP42_WT_2":"589116.5","RBP42_WT_3":"394883.8","RBP42_WT_4":"385199.4","RBP42_KD_1":"663736.8","RBP42_KD_2":"503047.8","RBP42_KD_3":"369329.6","RBP42_KD_4":"434126"},{"Metabolite":"Thiamine","RBP42_WT_1":"9694098","RBP42_WT_2":"1.32E+07","RBP42_WT_3":"8876337","RBP42_WT_4":"7943272","RBP42_KD_1":"1.36E+07","RBP42_KD_2":"9971077","RBP42_KD_3":"7312740","RBP42_KD_4":"7503942"},{"Metabolite":"Glucose","RBP42_WT_1":"5.96E+07","RBP42_WT_2":"7.40E+07","RBP42_WT_3":"4.80E+07","RBP42_WT_4":"4.96E+07","RBP42_KD_1":"8.08E+07","RBP42_KD_2":"6.80E+07","RBP42_KD_3":"5.08E+07","RBP42_KD_4":"5.58E+07"},{"Metabolite":"Proline","RBP42_WT_1":"7922842","RBP42_WT_2":"8660395","RBP42_WT_3":"7059220","RBP42_WT_4":"6267546","RBP42_KD_1":"7164228","RBP42_KD_2":"6073848","RBP42_KD_3":"5187998","RBP42_KD_4":"4970484"},{"Metabolite":"Sorbitol","RBP42_WT_1":"5088598","RBP42_WT_2":"6287040","RBP42_WT_3":"4613870","RBP42_WT_4":"4164071","RBP42_KD_1":"6233604","RBP42_KD_2":"5346120","RBP42_KD_3":"4180838","RBP42_KD_4":"4184576"},{"Metabolite":"Dimethylglycine","RBP42_WT_1":"50457.52","RBP42_WT_2":"91962.09","RBP42_WT_3":"45547.76","RBP42_WT_4":"52813.03","RBP42_KD_1":"84680.61","RBP42_KD_2":"69603.37","RBP42_KD_3":"78784.35","RBP42_KD_4":"58863.94"},{"Metabolite":"Valine","RBP42_WT_1":"1.62E+07","RBP42_WT_2":"2.21E+07","RBP42_WT_3":"1.46E+07","RBP42_WT_4":"1.34E+07","RBP42_KD_1":"2.20E+07","RBP42_KD_2":"1.65E+07","RBP42_KD_3":"1.30E+07","RBP42_KD_4":"1.28E+07"},{"Metabolite":"Tyrosine","RBP42_WT_1":"6502492","RBP42_WT_2":"9816421","RBP42_WT_3":"5770568","RBP42_WT_4":"5764534","RBP42_KD_1":"1.05E+07","RBP42_KD_2":"8024352","RBP42_KD_3":"5959964","RBP42_KD_4":"6286144"},{"Metabolite":"Taurine","RBP42_WT_1":"629329.2","RBP42_WT_2":"680871.2","RBP42_WT_3":"513252.2","RBP42_WT_4":"474246.1","RBP42_KD_1":"612896.2","RBP42_KD_2":"509181.9","RBP42_KD_3":"388084","RBP42_KD_4":"380370.5"},{"Metabolite":"Ribitol","RBP42_WT_1":"298532.3","RBP42_WT_2":"408034.5","RBP42_WT_3":"260915.9","RBP42_WT_4":"275997.7","RBP42_KD_1":"430251.9","RBP42_KD_2":"304452.3","RBP42_KD_3":"249621.5","RBP42_KD_4":"287552.8"},{"Metabolite":"Methionine","RBP42_WT_1":"3595853","RBP42_WT_2":"5081370","RBP42_WT_3":"3145631","RBP42_WT_4":"3177078","RBP42_KD_1":"5435460","RBP42_KD_2":"4178261","RBP42_KD_3":"3065839","RBP42_KD_4":"3252741"},{"Metabolite":"Pantothenate","RBP42_WT_1":"1265767","RBP42_WT_2":"2023711","RBP42_WT_3":"1112474","RBP42_WT_4":"1022858","RBP42_KD_1":"2341719","RBP42_KD_2":"1423773","RBP42_KD_3":"922306.6","RBP42_KD_4":"959123.2"},{"Metabolite":"Isoleucine","RBP42_WT_1":"2.83E+07","RBP42_WT_2":"3.86E+07","RBP42_WT_3":"2.48E+07","RBP42_WT_4":"2.32E+07","RBP42_KD_1":"4.02E+07","RBP42_KD_2":"3.11E+07","RBP42_KD_3":"2.16E+07","RBP42_KD_4":"2.43E+07"},{"Metabolite":"Xanthine","RBP42_WT_1":"3813580","RBP42_WT_2":"5214220","RBP42_WT_3":"4097098","RBP42_WT_4":"3414511","RBP42_KD_1":"3381169","RBP42_KD_2":"2682985","RBP42_KD_3":"2184134","RBP42_KD_4":"2129372"},{"Metabolite":"Glycine-L-leucine","RBP42_WT_1":"10612.43","RBP42_WT_2":"18624.95","RBP42_WT_3":"7552.376","RBP42_WT_4":"7711.502","RBP42_KD_1":"16088.46","RBP42_KD_2":"12360.27","RBP42_KD_3":"5338.59","RBP42_KD_4":"7894.793"},{"Metabolite":"Lactate","RBP42_WT_1":"6.34E+07","RBP42_WT_2":"8.59E+07","RBP42_WT_3":"5.35E+07","RBP42_WT_4":"4.91E+07","RBP42_KD_1":"8.75E+07","RBP42_KD_2":"6.89E+07","RBP42_KD_3":"5.11E+07","RBP42_KD_4":"5.44E+07"},{"Metabolite":"Cytidine","RBP42_WT_1":"14948.67","RBP42_WT_2":"24587.13","RBP42_WT_3":"17681.35","RBP42_WT_4":"16557.43","RBP42_KD_1":"24850.5","RBP42_KD_2":"21746.79","RBP42_KD_3":"16344.89","RBP42_KD_4":"21242.49"},{"Metabolite":"Leucine","RBP42_WT_1":"1.70E+07","RBP42_WT_2":"2.33E+07","RBP42_WT_3":"1.47E+07","RBP42_WT_4":"1.44E+07","RBP42_KD_1":"2.44E+07","RBP42_KD_2":"2.01E+07","RBP42_KD_3":"1.38E+07","RBP42_KD_4":"1.48E+07"},{"Metabolite":"Kynurenine","RBP42_WT_1":"2845.684","RBP42_WT_2":"7467.251","RBP42_WT_3":"6649.612","RBP42_WT_4":"2983.358","RBP42_KD_1":"8168.677","RBP42_KD_2":"8718.11","RBP42_KD_3":"4773.415","RBP42_KD_4":"4236.316"},{"Metabolite":"Phenylalanine","RBP42_WT_1":"1.10E+07","RBP42_WT_2":"1.59E+07","RBP42_WT_3":"9798566","RBP42_WT_4":"9740857","RBP42_KD_1":"1.96E+07","RBP42_KD_2":"1.65E+07","RBP42_KD_3":"1.13E+07","RBP42_KD_4":"1.18E+07"},{"Metabolite":"Guanine","RBP42_WT_1":"81292.62","RBP42_WT_2":"81479.16","RBP42_WT_3":"84236.43","RBP42_WT_4":"61584.72","RBP42_KD_1":"46173.58","RBP42_KD_2":"28647.17","RBP42_KD_3":"33599.27","RBP42_KD_4":"29136.16"},{"Metabolite":"Tryptophan","RBP42_WT_1":"2337712","RBP42_WT_2":"3440983","RBP42_WT_3":"2196678","RBP42_WT_4":"2107242","RBP42_KD_1":"3794321","RBP42_KD_2":"3121507","RBP42_KD_3":"2162076","RBP42_KD_4":"2298896"},{"Metabolite":"2-Hydroxybutyric acid","RBP42_WT_1":"150850.4","RBP42_WT_2":"179933.2","RBP42_WT_3":"147999","RBP42_WT_4":"128957","RBP42_KD_1":"194112.9","RBP42_KD_2":"176702","RBP42_KD_3":"175361.3","RBP42_KD_4":"167680.1"},{"Metabolite":"Creatinine","RBP42_WT_1":"611473.5","RBP42_WT_2":"791118.3","RBP42_WT_3":"530552.2","RBP42_WT_4":"539640.8","RBP42_KD_1":"779531.2","RBP42_KD_2":"699748.8","RBP42_KD_3":"518281.7","RBP42_KD_4":"582713.3"},{"Metabolite":"Hypoxanthine","RBP42_WT_1":"5.29E+07","RBP42_WT_2":"7.82E+07","RBP42_WT_3":"4.55E+07","RBP42_WT_4":"3.98E+07","RBP42_KD_1":"8.00E+07","RBP42_KD_2":"5.98E+07","RBP42_KD_3":"4.09E+07","RBP42_KD_4":"4.36E+07"},{"Metabolite":"Acetyl-Methionine","RBP42_WT_1":"11058.92","RBP42_WT_2":"12825.31","RBP42_WT_3":"8480.817","RBP42_WT_4":"6943.697","RBP42_KD_1":"3105.378","RBP42_KD_2":"2603.593","RBP42_KD_3":"2399.666","RBP42_KD_4":"2101.219"},{"Metabolite":"Uridine","RBP42_WT_1":"201537.8","RBP42_WT_2":"274378","RBP42_WT_3":"205102.8","RBP42_WT_4":"192487.3","RBP42_KD_1":"272422.9","RBP42_KD_2":"237671.3","RBP42_KD_3":"191321.4","RBP42_KD_4":"209275.1"},{"Metabolite":"Hydroxyphenyllactic acid","RBP42_WT_1":"94466.07","RBP42_WT_2":"156674.2","RBP42_WT_3":"101643.9","RBP42_WT_4":"75736.26","RBP42_KD_1":"95714.79","RBP42_KD_2":"84108.88","RBP42_KD_3":"56704.1","RBP42_KD_4":"66518.45"},{"Metabolite":"Pyruvate","RBP42_WT_1":"5.72E+07","RBP42_WT_2":"6.24E+07","RBP42_WT_3":"4.99E+07","RBP42_WT_4":"4.59E+07","RBP42_KD_1":"5.46E+07","RBP42_KD_2":"4.30E+07","RBP42_KD_3":"4.02E+07","RBP42_KD_4":"3.96E+07"},{"Metabolite":"Isovalerylglycine","RBP42_WT_1":"23835.11","RBP42_WT_2":"46302.19","RBP42_WT_3":"29209.01","RBP42_WT_4":"26350.62","RBP42_KD_1":"43405.61","RBP42_KD_2":"30990.96","RBP42_KD_3":"17686.34","RBP42_KD_4":"22408.11"},{"Metabolite":"Adenine","RBP42_WT_1":"1366010","RBP42_WT_2":"1858975","RBP42_WT_3":"1795065","RBP42_WT_4":"1552054","RBP42_KD_1":"717172.5","RBP42_KD_2":"1253348","RBP42_KD_3":"902447.4","RBP42_KD_4":"676345.4"},{"Metabolite":"Hippuric acid","RBP42_WT_1":"420825.5","RBP42_WT_2":"603496.1","RBP42_WT_3":"386617.2","RBP42_WT_4":"369366.2","RBP42_KD_1":"617244.2","RBP42_KD_2":"499052.2","RBP42_KD_3":"351685.8","RBP42_KD_4":"364980.8"},{"Metabolite":"Pyridoxine","RBP42_WT_1":"15029.28","RBP42_WT_2":"19228.49","RBP42_WT_3":"17588.04","RBP42_WT_4":"12855.31","RBP42_KD_1":"14389.85","RBP42_KD_2":"11778.29","RBP42_KD_3":"3305.535","RBP42_KD_4":"7042.303"},{"Metabolite":"Phenylethanolamine","RBP42_WT_1":"22450.32","RBP42_WT_2":"24358.74","RBP42_WT_3":"24969.75","RBP42_WT_4":"20094.53","RBP42_KD_1":"19757.28","RBP42_KD_2":"12927.44","RBP42_KD_3":"23342.35","RBP42_KD_4":"25419.73"},{"Metabolite":"Kynurenic acid","RBP42_WT_1":"5395.273","RBP42_WT_2":"7679.681","RBP42_WT_3":"2793.028","RBP42_WT_4":"5300.624","RBP42_KD_1":"10385.95","RBP42_KD_2":"7307.35","RBP42_KD_3":"4159.809","RBP42_KD_4":"2519.837"},{"Metabolite":"p-coumaric acid","RBP42_WT_1":"9147668","RBP42_WT_2":"9944337","RBP42_WT_3":"7839418","RBP42_WT_4":"7497660","RBP42_KD_1":"6690070","RBP42_KD_2":"5547260","RBP42_KD_3":"5172710","RBP42_KD_4":"5170858"},{"Metabolite":"Hydroxy-methoxycinnamic acid","RBP42_WT_1":"43155.57","RBP42_WT_2":"38431.06","RBP42_WT_3":"39787.68","RBP42_WT_4":"41219.44","RBP42_KD_1":"19286.15","RBP42_KD_2":"32655.1","RBP42_KD_3":"47039.49","RBP42_KD_4":"20463.64"},{"Metabolite":"Quinaldic acid","RBP42_WT_1":"16255.39","RBP42_WT_2":"16852.46","RBP42_WT_3":"9454.127","RBP42_WT_4":"10192.33","RBP42_KD_1":"23543.43","RBP42_KD_2":"11027.88","RBP42_KD_3":"12202.27","RBP42_KD_4":"7328.659"},{"Metabolite":"Phenylacetylglycine","RBP42_WT_1":"66623.16","RBP42_WT_2":"85738.13","RBP42_WT_3":"55973.76","RBP42_WT_4":"50861.52","RBP42_KD_1":"87545.96","RBP42_KD_2":"67064.16","RBP42_KD_3":"44463.99","RBP42_KD_4":"44703.78"},{"Metabolite":"Indole-3-carboxylic acid","RBP42_WT_1":"199485.2","RBP42_WT_2":"238491.4","RBP42_WT_3":"172410","RBP42_WT_4":"148296.9","RBP42_KD_1":"227809.5","RBP42_KD_2":"153470.5","RBP42_KD_3":"160132.4","RBP42_KD_4":"134471.3"},{"Metabolite":"Leucic acid","RBP42_WT_1":"3096091","RBP42_WT_2":"3691697","RBP42_WT_3":"3680286","RBP42_WT_4":"3190583","RBP42_KD_1":"596477.5","RBP42_KD_2":"759652.8","RBP42_KD_3":"693179.2","RBP42_KD_4":"640408.2"},{"Metabolite":"Uracil","RBP42_WT_1":"1661226","RBP42_WT_2":"2243890","RBP42_WT_3":"2059851","RBP42_WT_4":"1862544","RBP42_KD_1":"1283227","RBP42_KD_2":"1422128","RBP42_KD_3":"1265028","RBP42_KD_4":"1217795"},{"Metabolite":"Indolelactic acid","RBP42_WT_1":"74203.62","RBP42_WT_2":"88401.52","RBP42_WT_3":"72576.68","RBP42_WT_4":"63840.47","RBP42_KD_1":"66380.21","RBP42_KD_2":"60788.71","RBP42_KD_3":"47693.55","RBP42_KD_4":"54234.62"},{"Metabolite":"Thymidine","RBP42_WT_1":"1.40E+07","RBP42_WT_2":"1.70E+07","RBP42_WT_3":"1.32E+07","RBP42_WT_4":"1.22E+07","RBP42_KD_1":"1.82E+07","RBP42_KD_2":"1.54E+07","RBP42_KD_3":"1.41E+07","RBP42_KD_4":"1.43E+07"},{"Metabolite":"3-Methyl-2-oxovaleric acid","RBP42_WT_1":"5.95E+07","RBP42_WT_2":"6.82E+07","RBP42_WT_3":"5.34E+07","RBP42_WT_4":"5.20E+07","RBP42_KD_1":"6.90E+07","RBP42_KD_2":"5.89E+07","RBP42_KD_3":"5.09E+07","RBP42_KD_4":"4.83E+07"},{"Metabolite":"2-Ketoisovalerate","RBP42_WT_1":"1.66E+07","RBP42_WT_2":"1.73E+07","RBP42_WT_3":"1.52E+07","RBP42_WT_4":"1.39E+07","RBP42_KD_1":"1.74E+07","RBP42_KD_2":"1.49E+07","RBP42_KD_3":"1.31E+07","RBP42_KD_4":"1.24E+07"},{"Metabolite":"Hydroxyphenyl pyruvate","RBP42_WT_1":"2058331","RBP42_WT_2":"2421125","RBP42_WT_3":"1825735","RBP42_WT_4":"1632974","RBP42_KD_1":"1602498","RBP42_KD_2":"1332414","RBP42_KD_3":"1248481","RBP42_KD_4":"1163509"},{"Metabolite":"Deoxycholylglycine","RBP42_WT_1":"16187.04","RBP42_WT_2":"42831.69","RBP42_WT_3":"13956.36","RBP42_WT_4":"28161.5","RBP42_KD_1":"54799.21","RBP42_KD_2":"41910.58","RBP42_KD_3":"26149.78","RBP42_KD_4":"24338.45"},{"Metabolite":"Cresol","RBP42_WT_1":"170542.3","RBP42_WT_2":"214248.5","RBP42_WT_3":"167115.2","RBP42_WT_4":"127792.3","RBP42_KD_1":"141213.7","RBP42_KD_2":"134699.4","RBP42_KD_3":"107491.8","RBP42_KD_4":"107521.2"},{"Metabolite":"2-Phenylbutyric acid","RBP42_WT_1":"30041.86","RBP42_WT_2":"16922.44","RBP42_WT_3":"21337.39","RBP42_WT_4":"19175.08","RBP42_KD_1":"20719.21","RBP42_KD_2":"34220.61","RBP42_KD_3":"30128.27","RBP42_KD_4":"23515.63"},{"Metabolite":"Pyridoxic acid","RBP42_WT_1":"85940.82","RBP42_WT_2":"137349.3","RBP42_WT_3":"82010.24","RBP42_WT_4":"72586.59","RBP42_KD_1":"133574.8","RBP42_KD_2":"91759.1","RBP42_KD_3":"68487.15","RBP42_KD_4":"71686.41"},{"Metabolite":"N-octanoylglycine","RBP42_WT_1":"161038.7","RBP42_WT_2":"136524.7","RBP42_WT_3":"176919.8","RBP42_WT_4":"153100.3","RBP42_KD_1":"131542.6","RBP42_KD_2":"152420.6","RBP42_KD_3":"158733.1","RBP42_KD_4":"154619.7"},{"Metabolite":"Dihydroxybenzeneacetic acid","RBP42_WT_1":"40670.99","RBP42_WT_2":"32118.33","RBP42_WT_3":"42087.69","RBP42_WT_4":"57948.92","RBP42_KD_1":"35187.1","RBP42_KD_2":"51965.93","RBP42_KD_3":"61387.12","RBP42_KD_4":"53780.41"},{"Metabolite":"Cinnamic acid","RBP42_WT_1":"119100.2","RBP42_WT_2":"118122.7","RBP42_WT_3":"125886.9","RBP42_WT_4":"104581.6","RBP42_KD_1":"12692.87","RBP42_KD_2":"50538.3","RBP42_KD_3":"19862.95","RBP42_KD_4":"23684.94"},{"Metabolite":"Methylphenyllactate","RBP42_WT_1":"52145.62","RBP42_WT_2":"57118.1","RBP42_WT_3":"63617.43","RBP42_WT_4":"51705.47","RBP42_KD_1":"63386.45","RBP42_KD_2":"55830.61","RBP42_KD_3":"72629.26","RBP42_KD_4":"59711.46"},{"Metabolite":"5-Phenylvaleric acid","RBP42_WT_1":"28172.24","RBP42_WT_2":"25434.11","RBP42_WT_3":"28059.32","RBP42_WT_4":"29041.85","RBP42_KD_1":"39148.8","RBP42_KD_2":"32125.88","RBP42_KD_3":"29044.34","RBP42_KD_4":"33848.88"},{"Metabolite":"UDP","RBP42_WT_1":"38353.39","RBP42_WT_2":"32091.72","RBP42_WT_3":"41273.91","RBP42_WT_4":"35396.77","RBP42_KD_1":"16464.9","RBP42_KD_2":"5981.711","RBP42_KD_3":"17646.07","RBP42_KD_4":"13664.42"},{"Metabolite":"Thymine","RBP42_WT_1":"92760.88","RBP42_WT_2":"141982","RBP42_WT_3":"95045.51","RBP42_WT_4":"90497.46","RBP42_KD_1":"125912.6","RBP42_KD_2":"111586.2","RBP42_KD_3":"90457.15","RBP42_KD_4":"89590.63"},{"Metabolite":"Phosphoenolpyruvate","RBP42_WT_1":"36294.46","RBP42_WT_2":"39700.89","RBP42_WT_3":"42211.76","RBP42_WT_4":"38842.59","RBP42_KD_1":"33141.12","RBP42_KD_2":"32227.62","RBP42_KD_3":"33266.85","RBP42_KD_4":"38361.05"},{"Metabolite":"Orotate","RBP42_WT_1":"30927.9","RBP42_WT_2":"33311.25","RBP42_WT_3":"28128.1","RBP42_WT_4":"19399.53","RBP42_KD_1":"36441.06","RBP42_KD_2":"34106.91","RBP42_KD_3":"21562.59","RBP42_KD_4":"10909.75"},{"Metabolite":"O-Propanoylcarnitine","RBP42_WT_1":"571712.4","RBP42_WT_2":"497399.2","RBP42_WT_3":"977661.5","RBP42_WT_4":"426655.8","RBP42_KD_1":"901562.3","RBP42_KD_2":"709560.2","RBP42_KD_3":"419929.9","RBP42_KD_4":"714805.5"},{"Metabolite":"O-Decanoyl-L-carnitine","RBP42_WT_1":"38153.62","RBP42_WT_2":"40652.1","RBP42_WT_3":"53467.43","RBP42_WT_4":"50781.95","RBP42_KD_1":"75586.56","RBP42_KD_2":"64370.62","RBP42_KD_3":"43833.7","RBP42_KD_4":"53748.34"},{"Metabolite":"O-Butanoylcarnitine","RBP42_WT_1":"103522.9","RBP42_WT_2":"65581.62","RBP42_WT_3":"205798.8","RBP42_WT_4":"77585.8","RBP42_KD_1":"185819.4","RBP42_KD_2":"157048.1","RBP42_KD_3":"72427.32","RBP42_KD_4":"141234.5"},{"Metabolite":"Mannose-6-phosphate","RBP42_WT_1":"272365.8","RBP42_WT_2":"255585.8","RBP42_WT_3":"212872","RBP42_WT_4":"209779.8","RBP42_KD_1":"286405.9","RBP42_KD_2":"189194","RBP42_KD_3":"229377.2","RBP42_KD_4":"225113"},{"Metabolite":"Inosine","RBP42_WT_1":"252486.4","RBP42_WT_2":"244497.1","RBP42_WT_3":"216824.9","RBP42_WT_4":"166661.5","RBP42_KD_1":"330242.2","RBP42_KD_2":"313608.8","RBP42_KD_3":"149417.4","RBP42_KD_4":"237618.2"},{"Metabolite":"IMP","RBP42_WT_1":"35500.13","RBP42_WT_2":"41594.12","RBP42_WT_3":"49089.45","RBP42_WT_4":"37390.07","RBP42_KD_1":"25491.72","RBP42_KD_2":"26027.73","RBP42_KD_3":"36273.36","RBP42_KD_4":"30676.12"},{"Metabolite":"GDP","RBP42_WT_1":"24125.71","RBP42_WT_2":"21407.54","RBP42_WT_3":"22120.49","RBP42_WT_4":"18875.13","RBP42_KD_1":"14975.12","RBP42_KD_2":"13102.38","RBP42_KD_3":"15006.27","RBP42_KD_4":"13352.38"},{"Metabolite":"Citrulline","RBP42_WT_1":"198629.2","RBP42_WT_2":"279729.9","RBP42_WT_3":"166108.8","RBP42_WT_4":"149473.5","RBP42_KD_1":"216978.1","RBP42_KD_2":"156338.6","RBP42_KD_3":"137088.3","RBP42_KD_4":"141126.7"},{"Metabolite":"Carbamoyl phosphate","RBP42_WT_1":"5386.963","RBP42_WT_2":"11506.9","RBP42_WT_3":"8320.571","RBP42_WT_4":"5561.054","RBP42_KD_1":"6293.391","RBP42_KD_2":"10143.83","RBP42_KD_3":"4548.417","RBP42_KD_4":"4757.08"},{"Metabolite":"Acetoacetate","RBP42_WT_1":"6422912","RBP42_WT_2":"8012040","RBP42_WT_3":"5177302","RBP42_WT_4":"5586044","RBP42_KD_1":"8670611","RBP42_KD_2":"7292994","RBP42_KD_3":"5786530","RBP42_KD_4":"6237162"},{"Metabolite":"3-Phosphoserine","RBP42_WT_1":"4397.524","RBP42_WT_2":"6547.057","RBP42_WT_3":"3507.307","RBP42_WT_4":"6300.922","RBP42_KD_1":"17816.85","RBP42_KD_2":"9420.669","RBP42_KD_3":"4029.977","RBP42_KD_4":"4785.197"},{"Metabolite":"3-Phosphoglycerate","RBP42_WT_1":"91801.22","RBP42_WT_2":"120997.6","RBP42_WT_3":"115768.4","RBP42_WT_4":"108656.6","RBP42_KD_1":"106545.7","RBP42_KD_2":"97014.74","RBP42_KD_3":"95292.84","RBP42_KD_4":"119728.6"}],

"Metabolites":[{"Metabolite":"GTP","medMz":"521.9832","medRt":"13.18631"},{"Metabolite":"UTP","medMz":"482.9611","medRt":"12.55356"},{"Metabolite":"Fructose-1 6-bisphosphate","medMz":"338.989","medRt":"13.10606"},{"Metabolite":"Thiamine pyrophosphate","medMz":"423.0299","medRt":"12.96512"},{"Metabolite":"ATP","medMz":"505.9886","medRt":"11.92494"},{"Metabolite":"Lysine","medMz":"145.0982","medRt":"12.96665"},{"Metabolite":"NADP+","medMz":"742.0695","medRt":"11.75559"},{"Metabolite":"Citrate","medMz":"191.0199","medRt":"11.04854"},{"Metabolite":"Arginine","medMz":"173.1043","medRt":"12.23549"},{"Metabolite":"Ornithine","medMz":"131.0827","medRt":"12.28592"},{"Metabolite":"Glucose-6-phosphate","medMz":"259.0223","medRt":"10.452"},{"Metabolite":"Phosphocholine (+HAc)","medMz":"242.08","medRt":"10.77409"},{"Metabolite":"ADP","medMz":"426.0222","medRt":"10.31027"},{"Metabolite":"Isocitrate","medMz":"191.02","medRt":"10.09772"},{"Metabolite":"GMP","medMz":"362.0509","medRt":"10.10491"},{"Metabolite":"D-glucosamine-1 6-phosphate","medMz":"258.0385","medRt":"10.41457"},{"Metabolite":"CMP","medMz":"322.0447","medRt":"9.924671"},{"Metabolite":"Fructose-6-phosphate","medMz":"259.0224","medRt":"9.842308"},{"Metabolite":"D-erythrose-4-phosphate","medMz":"199.0012","medRt":"10.45719"},{"Metabolite":"NG-dimethyl-L-arginine","medMz":"201.1357","medRt":"10.74558"},{"Metabolite":"S-adenosyl-L-methionine","medMz":"356.1035","medRt":"10.26982"},{"Metabolite":"Aconitate","medMz":"173.009","medRt":"9.565619"},{"Metabolite":"UDP-D-Glucose","medMz":"565.0481","medRt":"9.535654"},{"Metabolite":"Cystathionine","medMz":"221.0605","medRt":"9.823723"},{"Metabolite":"CDP-Choline (+HAc)","medMz":"547.1211","medRt":"9.708165"},{"Metabolite":"UMP","medMz":"323.0287","medRt":"9.441568"},{"Metabolite":"Ribose phosphate","medMz":"229.0118","medRt":"9.402166"},{"Metabolite":"NAD+","medMz":"662.1022","medRt":"9.465322"},{"Metabolite":"Folate","medMz":"440.1325","medRt":"9.234333"},{"Metabolite":"UDP-N-acetyl-glucosamine","medMz":"606.0744","medRt":"9.279254"},{"Metabolite":"Dihydroxyacetone phosphate","medMz":"168.9907","medRt":"9.290911"},{"Metabolite":"Glycerol-3-phosphate","medMz":"171.0064","medRt":"9.341466"},{"Metabolite":"Coenzyme A","medMz":"382.5503","medRt":"9.293061"},{"Metabolite":"Cystine","medMz":"239.0167","medRt":"9.294811"},{"Metabolite":"AMP","medMz":"346.0558","medRt":"9.213064"},{"Metabolite":"Acetyl CoA","medMz":"403.5556","medRt":"8.914256"},{"Metabolite":"Malate","medMz":"133.0143","medRt":"8.590994"},{"Metabolite":"Carnosine","medMz":"225.099","medRt":"9.018508"},{"Metabolite":"Aminoadipic acid","medMz":"160.0616","medRt":"8.739664"},{"Metabolite":"Glutathione","medMz":"306.0766","medRt":"8.565213"},{"Metabolite":"Aspartate","medMz":"132.0303","medRt":"8.586962"},{"Metabolite":"Glutamate","medMz":"146.0459","medRt":"8.515523"},{"Metabolite":"N-Acetylaspartate","medMz":"174.0408","medRt":"8.319273"},{"Metabolite":"2-Hydroxyglutarate","medMz":"147.0299","medRt":"8.344949"},{"Metabolite":"Glucuronic acid","medMz":"193.0352","medRt":"8.224719"},{"Metabolite":"Succinate","medMz":"117.0194","medRt":"8.195569"},{"Metabolite":"N-acetyl-glutamate","medMz":"188.0562","medRt":"8.076452"},{"Metabolite":"Inositol","medMz":"179.056","medRt":"8.357656"},{"Metabolite":"Methylsuccinic acid","medMz":"131.0349","medRt":"8.025447"},{"Metabolite":"Glycerophosphocholine (+HAc)","medMz":"316.1167","medRt":"8.02558"},{"Metabolite":"Oxaloacetate","medMz":"130.9988","medRt":"7.495169"},{"Metabolite":"a-ketoglutarate","medMz":"145.0141","medRt":"7.308839"},{"Metabolite":"Homocitrulline","medMz":"188.1044","medRt":"7.554075"},{"Metabolite":"Asparagine","medMz":"131.0462","medRt":"7.505708"},{"Metabolite":"Serine","medMz":"104.0354","medRt":"7.506913"},{"Metabolite":"Glutamine","medMz":"145.0617","medRt":"7.354627"},{"Metabolite":"Hisidine","medMz":"154.0623","medRt":"8.055569"},{"Metabolite":"1-Methylhistidine","medMz":"168.0779","medRt":"7.529992"},{"Metabolite":"Shikimate","medMz":"173.0455","medRt":"7.407607"},{"Metabolite":"Methionine sulfoxide","medMz":"164.0385","medRt":"7.164221"},{"Metabolite":"Glycine","medMz":"74.02479","medRt":"7.021532"},{"Metabolite":"Threonine","medMz":"118.0511","medRt":"6.729527"},{"Metabolite":"Alanine","medMz":"88.04036","medRt":"6.710689"},{"Metabolite":"Threonic acid","medMz":"135.0299","medRt":"6.147098"},{"Metabolite":"Hydroxyproline","medMz":"130.0512","medRt":"6.558372"},{"Metabolite":"Creatine","medMz":"130.0625","medRt":"6.576329"},{"Metabolite":"Uric acid","medMz":"167.0211","medRt":"5.999434"},{"Metabolite":"Thiamine","medMz":"263.0972","medRt":"6.157244"},{"Metabolite":"Glucose","medMz":"179.0561","medRt":"5.843518"},{"Metabolite":"Proline","medMz":"114.056","medRt":"5.855082"},{"Metabolite":"Sorbitol","medMz":"181.0718","medRt":"5.824417"},{"Metabolite":"Dimethylglycine","medMz":"102.0561","medRt":"5.971803"},{"Metabolite":"Valine","medMz":"116.0717","medRt":"5.439665"},{"Metabolite":"Tyrosine","medMz":"180.0666","medRt":"5.078292"},{"Metabolite":"Taurine","medMz":"124.0074","medRt":"5.46658"},{"Metabolite":"Ribitol","medMz":"151.0612","medRt":"4.7338"},{"Metabolite":"Methionine","medMz":"148.0437","medRt":"4.529335"},{"Metabolite":"Pantothenate","medMz":"218.1033","medRt":"4.310317"},{"Metabolite":"Isoleucine","medMz":"130.0873","medRt":"4.375795"},{"Metabolite":"Xanthine","medMz":"151.0261","medRt":"3.97084"},{"Metabolite":"Glycine-L-leucine","medMz":"187.1086","medRt":"4.170506"},{"Metabolite":"Lactate","medMz":"89.02438","medRt":"4.123072"},{"Metabolite":"Cytidine","medMz":"242.078","medRt":"3.990331"},{"Metabolite":"Leucine","medMz":"130.0873","medRt":"3.993815"},{"Metabolite":"Kynurenine","medMz":"207.0777","medRt":"3.609444"},{"Metabolite":"Phenylalanine","medMz":"164.0717","medRt":"3.563568"},{"Metabolite":"Guanine","medMz":"150.0421","medRt":"3.434963"},{"Metabolite":"Tryptophan","medMz":"203.0827","medRt":"3.424481"},{"Metabolite":"2-Hydroxybutyric acid","medMz":"103.0401","medRt":"3.27393"},{"Metabolite":"Creatinine","medMz":"112.0516","medRt":"2.827087"},{"Metabolite":"Hypoxanthine","medMz":"135.0313","medRt":"2.889767"},{"Metabolite":"Acetyl-Methionine","medMz":"190.0546","medRt":"2.719431"},{"Metabolite":"Uridine","medMz":"243.0621","medRt":"2.7567"},{"Metabolite":"Hydroxyphenyllactic acid","medMz":"181.0507","medRt":"2.651373"},{"Metabolite":"Pyruvate","medMz":"87.0087","medRt":"2.579701"},{"Metabolite":"Isovalerylglycine","medMz":"158.0821","medRt":"2.588389"},{"Metabolite":"Adenine","medMz":"134.0473","medRt":"2.578193"},{"Metabolite":"Hippuric acid","medMz":"178.0509","medRt":"2.482688"},{"Metabolite":"Pyridoxine","medMz":"168.0665","medRt":"2.440977"},{"Metabolite":"Phenylethanolamine","medMz":"136.077","medRt":"2.167748"},{"Metabolite":"Kynurenic acid","medMz":"188.0356","medRt":"2.397581"},{"Metabolite":"p-coumaric acid","medMz":"163.0401","medRt":"1.984935"},{"Metabolite":"Hydroxy-methoxycinnamic acid","medMz":"193.0505","medRt":"1.990558"},{"Metabolite":"Quinaldic acid","medMz":"172.0403","medRt":"2.354448"},{"Metabolite":"Phenylacetylglycine","medMz":"192.0668","medRt":"2.290288"},{"Metabolite":"Indole-3-carboxylic acid","medMz":"160.0405","medRt":"1.988879"},{"Metabolite":"Leucic acid","medMz":"131.0714","medRt":"2.223804"},{"Metabolite":"Uracil","medMz":"111.02","medRt":"2.160694"},{"Metabolite":"Indolelactic acid","medMz":"204.0667","medRt":"2.071248"},{"Metabolite":"Thymidine","medMz":"241.083","medRt":"2.054741"},{"Metabolite":"3-Methyl-2-oxovaleric acid","medMz":"129.0558","medRt":"1.97942"},{"Metabolite":"2-Ketoisovalerate","medMz":"115.0401","medRt":"2.077981"},{"Metabolite":"Hydroxyphenyl pyruvate","medMz":"179.0349","medRt":"2.034176"},{"Metabolite":"Deoxycholylglycine","medMz":"448.3069","medRt":"2.0252"},{"Metabolite":"Cresol","medMz":"107.0503","medRt":"2.015033"},{"Metabolite":"2-Phenylbutyric acid","medMz":"163.0763","medRt":"1.984259"},{"Metabolite":"Pyridoxic acid","medMz":"182.046","medRt":"1.936941"},{"Metabolite":"N-octanoylglycine","medMz":"200.1293","medRt":"1.982277"},{"Metabolite":"Dihydroxybenzeneacetic acid","medMz":"167.035","medRt":"2.015394"},{"Metabolite":"Cinnamic acid","medMz":"147.0452","medRt":"2.050173"},{"Metabolite":"Methylphenyllactate","medMz":"149.0605","medRt":"1.996148"},{"Metabolite":"5-Phenylvaleric acid","medMz":"177.0922","medRt":"1.981848"},{"Metabolite":"UDP","medMz":"402.9954","medRt":"10.64415"},{"Metabolite":"Thymine","medMz":"125.0357","medRt":"7.353091"},{"Metabolite":"Phosphoenolpyruvate","medMz":"166.975","medRt":"9.913591"},{"Metabolite":"Orotate","medMz":"155.0099","medRt":"3.734529"},{"Metabolite":"O-Propanoylcarnitine","medMz":"216.1241","medRt":"2.948167"},{"Metabolite":"O-Decanoyl-L-carnitine","medMz":"314.2338","medRt":"1.264599"},{"Metabolite":"O-Butanoylcarnitine","medMz":"230.1396","medRt":"3.098904"},{"Metabolite":"Mannose-6-phosphate","medMz":"259.0224","medRt":"10.15473"},{"Metabolite":"Inosine","medMz":"267.0724","medRt":"5.865184"},{"Metabolite":"IMP","medMz":"347.0399","medRt":"9.616341"},{"Metabolite":"GDP","medMz":"442.0176","medRt":"11.88755"},{"Metabolite":"Citrulline","medMz":"174.0884","medRt":"7.987957"},{"Metabolite":"Carbamoyl phosphate","medMz":"139.9758","medRt":"6.113869"},{"Metabolite":"Acetoacetate","medMz":"101.0244","medRt":"5.872325"},{"Metabolite":"3-Phosphoserine","medMz":"184.0015","medRt":"8.475485"},{"Metabolite":"3-Phosphoglycerate","medMz":"184.9856","medRt":"10.22187"}]
}

}