{ "METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001828","ANALYSIS_ID":"AN002965","VERSION":"1","CREATED_ON":"June 14, 2021, 3:05 pm"}, "PROJECT":{"PROJECT_SUMMARY":"Preterm birth is the leading cause of infant mortality worldwide, and also greatly increases the risk of developing serious health complications in childhood and throughout life. Conditions that contribute to preterm birth remain largely unclear, though an influence by environmental exposures is suspected but poorly understood. In our preliminary work, we found that exposure to common chemicals, such as phthalates and bisphenol A (BPA), may contribute to this serious but understudied public health problem. We also observed strong associations between phthalates/BPA and general markers of oxidative stress, and in turn between these general markers of oxidative stress and risk of preterm birth. In this nested case-control study within an ongoing cohort of pregnant women in Puerto Rico (PROTECT), we will explore untargeted lipidomics, as well as levels of eicosanoids specific to arachidonic acid oxidation pathways, in relation to both environmental exposures and preterm birth.","INSTITUTE":"University of Michigan","DEPARTMENT":"Nutritional Sciences","LABORATORY":"Meeker Lab","FIRST_NAME":"John","ADDRESS":"Ann Arbor, MI","EMAIL":"meekerj@umich.edu","PHONE":"734-764-7184","PROJECT_TITLE":"Nested case–control study of environmental exposure within the ongoing Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) pregnancy cohort.","LAST_NAME":"Meeker"}, "STUDY":{"STUDY_TITLE":"Nested case–control study of environmental exposure within the ongoing Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) pregnancy cohort.","STUDY_SUMMARY":"Preterm birth is the leading cause of infant mortality worldwide, and also greatly increases the risk of developing serious health complications in childhood and throughout life. Conditions that contribute to preterm birth remain largely unclear, though an influence by environmental exposures is suspected but poorly understood. In our preliminary work, we found that exposure to common chemicals, such as phthalates and bisphenol A (BPA), may contribute to this serious but understudied public health problem. We also observed strong associations between phthalates/BPA and general markers of oxidative stress, and in turn between these general markers of oxidative stress and risk of preterm birth. In this nested case-control study within an ongoing cohort of pregnant women in Puerto Rico (PROTECT), we will explore untargeted lipidomics, as well as levels of eicosanoids specific to arachidonic acid oxidation pathways, in relation to both environmental exposures and preterm birth.","INSTITUTE":"University of Michigan","DEPARTMENT":"MRC2","LAST_NAME":"Kachman","FIRST_NAME":"Maureen","ADDRESS":"Ann Arbor, MI, 48105, USA","EMAIL":"mkachman@med.umich.edu","STUDY_TYPE":"Observational","PHONE":"734-232-0842"}, "SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"}, "SUBJECT_SAMPLE_FACTORS":[ { "Subject ID":"-", "Sample ID":"Sample0002", "Factors":{"PRETERM BIRTH":"YES"}, "Additional sample data":{"RAW_FILE_NAME":"20180810-EX00864-A003-IN0026-S00035268-P;20180810-EX00864-A003-IN0026-S00035268-N"} }, { "Subject ID":"-", "Sample ID":"Sample1001", "Factors":{"PRETERM BIRTH":"NO"}, "Additional sample 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