#METABOLOMICS WORKBENCH cwwong_20220511_144441 DATATRACK_ID:3242 STUDY_ID:ST002161 ANALYSIS_ID:AN003541 PROJECT_ID:PR001374 VERSION 1 CREATED_ON May 12, 2022, 8:30 am #PROJECT PR:PROJECT_TITLE Glycerate Production from Intestinal Fructose Metabolism Elevated by Dietary Fat PR:PROJECT_TITLE Induces Glucose Intolerance Through β-cell Damage PR:PROJECT_SUMMARY Dietary fructose, especially in the context of a high-fat western diet, has been PR:PROJECT_SUMMARY linked to type 2 diabetes. Although the effect of fructose on liver metabolism PR:PROJECT_SUMMARY has been extensively studied, a significant portion of the fructose is first PR:PROJECT_SUMMARY metabolized in the small intestine. Here we report that dietary fat enhances PR:PROJECT_SUMMARY intestinal fructose metabolism, which releases glycerate into the blood. High PR:PROJECT_SUMMARY systemic glycerate levels reduce pancreatic islet sizes and β-cell content, PR:PROJECT_SUMMARY thus inducing glucose intolerance. Our findings provide an additional link PR:PROJECT_SUMMARY between dietary fructose and diabetes that is modulated by dietary fat. PR:INSTITUTE Duke University PR:LAST_NAME Wong PR:FIRST_NAME Chi Wut PR:ADDRESS CEIMAS, 101 Science Dr. Room 2141, Durham, NC, 27709, USA PR:EMAIL chiwut.wong@duke.edu PR:PHONE 9495290320 #STUDY ST:STUDY_TITLE Glycerate Production from Intestinal Fructose Metabolism Elevated by Dietary Fat ST:STUDY_TITLE Induces Glucose Intolerance Through β-cell Damage ST:STUDY_SUMMARY Dietary fructose, especially in the context of a high-fat western diet, has been ST:STUDY_SUMMARY linked to type 2 diabetes. Although the effect of fructose on liver metabolism ST:STUDY_SUMMARY has been extensively studied, a significant portion of the fructose is first ST:STUDY_SUMMARY metabolized in the small intestine. Here we report that dietary fat enhances ST:STUDY_SUMMARY intestinal fructose metabolism, which releases glycerate into the blood. High ST:STUDY_SUMMARY systemic glycerate levels reduce pancreatic islet sizes and β-cell content, ST:STUDY_SUMMARY thus inducing glucose intolerance. Our findings provide an additional link ST:STUDY_SUMMARY between dietary fructose and diabetes that is modulated by dietary fat. ST:INSTITUTE Duke University ST:LAST_NAME Wong ST:FIRST_NAME Chi Wut ST:ADDRESS CEIMAS, 101 Science Dr. Room 2141, Durham, NC, 27709, USA ST:EMAIL chiwut.wong@duke.edu ST:PHONE 9495290320 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS 13163 13C-Fruc_HFD-HV_13163 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_HFD-HV_13163.mzXML SUBJECT_SAMPLE_FACTORS 13164 13C-Fruc_HFD-HV_13164 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_HFD-HV_13164.mzXML SUBJECT_SAMPLE_FACTORS 13165 13C-Fruc_HFD-HV_13165 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_HFD-HV_13165.mzXML SUBJECT_SAMPLE_FACTORS 13166 13C-Fruc_HFD-HV_13166 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_HFD-HV_13166.mzXML SUBJECT_SAMPLE_FACTORS 13167 13C-Fruc_HFD-HV_13167 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_HFD-HV_13167.mzXML SUBJECT_SAMPLE_FACTORS 13163 13C-Fruc_HFD-PV_13163 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_HFD-PV_13163.mzXML SUBJECT_SAMPLE_FACTORS 13164 13C-Fruc_HFD-PV_13164 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_HFD-PV_13164.mzXML SUBJECT_SAMPLE_FACTORS 13165 13C-Fruc_HFD-PV_13165 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_HFD-PV_13165.mzXML SUBJECT_SAMPLE_FACTORS 13166 13C-Fruc_HFD-PV_13166 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_HFD-PV_13166.mzXML SUBJECT_SAMPLE_FACTORS 13167 13C-Fruc_HFD-PV_13167 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_HFD-PV_13167.mzXML SUBJECT_SAMPLE_FACTORS 13168 13C-Fruc_LFD-HV_13168 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_LFD-HV_13168.mzXML SUBJECT_SAMPLE_FACTORS 13169 13C-Fruc_LFD-HV_13169 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_LFD-HV_13169.mzXML SUBJECT_SAMPLE_FACTORS 13170 13C-Fruc_LFD-HV_13170 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_LFD-HV_13170.mzXML SUBJECT_SAMPLE_FACTORS 13171 13C-Fruc_LFD-HV_13171 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_LFD-HV_13171.mzXML SUBJECT_SAMPLE_FACTORS 13172 13C-Fruc_LFD-HV_13172 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_LFD-HV_13172.mzXML SUBJECT_SAMPLE_FACTORS 13168 13C-Fruc_LFD-PV_13168 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_LFD-PV_13168.mzXML SUBJECT_SAMPLE_FACTORS 13169 13C-Fruc_LFD-PV_13169 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_LFD-PV_13169.mzXML SUBJECT_SAMPLE_FACTORS 13170 13C-Fruc_LFD-PV_13170 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_LFD-PV_13170.mzXML SUBJECT_SAMPLE_FACTORS 13171 13C-Fruc_LFD-PV_13171 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_LFD-PV_13171.mzXML SUBJECT_SAMPLE_FACTORS 13172 13C-Fruc_LFD-PV_13172 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=6; Experiment=LC-MS; RAW_FILE_NAME=13C-Fruc_LFD-PV_13172.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch1 Blank_batch1 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=1; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch1.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch10 Blank_batch10 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=10; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch10.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch11 Blank_batch11 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch11.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch2 Blank_batch2 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch2.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch3 Blank_batch3 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=3; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch3.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch4 Blank_batch4 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=4; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch4.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch5 Blank_batch5 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=5; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch5.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch6 Blank_batch6 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=6; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch6.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch7 Blank_batch7 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=7; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch7.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch8 Blank_batch8 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=8; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch8.mzXML SUBJECT_SAMPLE_FACTORS Blank_batch9 Blank_batch9 Genotype:Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Blank_batch9.mzXML SUBJECT_SAMPLE_FACTORS 13156 CON-HV_0_13156 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_0_13156.mzXML SUBJECT_SAMPLE_FACTORS 13157 CON-HV_0_13157 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_0_13157.mzXML SUBJECT_SAMPLE_FACTORS 13158 CON-HV_0_13158 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_0_13158.mzXML SUBJECT_SAMPLE_FACTORS 12156 CON-HV_120_12156 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_120_12156.mzXML SUBJECT_SAMPLE_FACTORS 12157 CON-HV_120_12157 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_120_12157.mzXML SUBJECT_SAMPLE_FACTORS 12158 CON-HV_120_12158 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_120_12158.mzXML SUBJECT_SAMPLE_FACTORS 12106 CON-HV_15_12106 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_15_12106.mzXML SUBJECT_SAMPLE_FACTORS 12107 CON-HV_15_12107 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_15_12107.mzXML SUBJECT_SAMPLE_FACTORS 12108 CON-HV_15_12108 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_15_12108.mzXML SUBJECT_SAMPLE_FACTORS 12109 CON-HV_15_12109 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_15_12109.mzXML SUBJECT_SAMPLE_FACTORS 12110 CON-HV_15_12110 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_15_12110.mzXML SUBJECT_SAMPLE_FACTORS 12116 CON-HV_30_12116 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_30_12116.mzXML SUBJECT_SAMPLE_FACTORS 12117 CON-HV_30_12117 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_30_12117.mzXML SUBJECT_SAMPLE_FACTORS 12118 CON-HV_30_12118 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_30_12118.mzXML SUBJECT_SAMPLE_FACTORS 12119 CON-HV_30_12119 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_30_12119.mzXML SUBJECT_SAMPLE_FACTORS 12120 CON-HV_30_12120 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_30_12120.mzXML SUBJECT_SAMPLE_FACTORS 12126 CON-HV_45_12126 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_45_12126.mzXML SUBJECT_SAMPLE_FACTORS 12127 CON-HV_45_12127 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_45_12127.mzXML SUBJECT_SAMPLE_FACTORS 12128 CON-HV_45_12128 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_45_12128.mzXML SUBJECT_SAMPLE_FACTORS 12129 CON-HV_45_12129 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_45_12129.mzXML SUBJECT_SAMPLE_FACTORS 12130 CON-HV_45_12130 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_45_12130.mzXML SUBJECT_SAMPLE_FACTORS 12136 CON-HV_60_12136 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_60_12136.mzXML SUBJECT_SAMPLE_FACTORS 12137 CON-HV_60_12137 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_60_12137.mzXML SUBJECT_SAMPLE_FACTORS 12138 CON-HV_60_12138 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_60_12138.mzXML SUBJECT_SAMPLE_FACTORS 12139 CON-HV_60_12139 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_60_12139.mzXML SUBJECT_SAMPLE_FACTORS 12140 CON-HV_60_12140 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_60_12140.mzXML SUBJECT_SAMPLE_FACTORS 12146 CON-HV_90_12146 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_90_12146.mzXML SUBJECT_SAMPLE_FACTORS 12147 CON-HV_90_12147 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_90_12147.mzXML SUBJECT_SAMPLE_FACTORS 12148 CON-HV_90_12148 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-HV_90_12148.mzXML SUBJECT_SAMPLE_FACTORS 13156 CON-PV_0_13156 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_0_13156.mzXML SUBJECT_SAMPLE_FACTORS 13157 CON-PV_0_13157 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_0_13157.mzXML SUBJECT_SAMPLE_FACTORS 13158 CON-PV_0_13158 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_0_13158.mzXML SUBJECT_SAMPLE_FACTORS 12156 CON-PV_120_12156 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_120_12156.mzXML SUBJECT_SAMPLE_FACTORS 12157 CON-PV_120_12157 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_120_12157.mzXML SUBJECT_SAMPLE_FACTORS 12158 CON-PV_120_12158 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_120_12158.mzXML SUBJECT_SAMPLE_FACTORS 12106 CON-PV_15_12106 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_15_12106.mzXML SUBJECT_SAMPLE_FACTORS 12107 CON-PV_15_12107 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_15_12107.mzXML SUBJECT_SAMPLE_FACTORS 12108 CON-PV_15_12108 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_15_12108.mzXML SUBJECT_SAMPLE_FACTORS 12109 CON-PV_15_12109 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_15_12109.mzXML SUBJECT_SAMPLE_FACTORS 12110 CON-PV_15_12110 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_15_12110.mzXML SUBJECT_SAMPLE_FACTORS 12116 CON-PV_30_12116 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_30_12116.mzXML SUBJECT_SAMPLE_FACTORS 12117 CON-PV_30_12117 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_30_12117.mzXML SUBJECT_SAMPLE_FACTORS 12118 CON-PV_30_12118 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_30_12118.mzXML SUBJECT_SAMPLE_FACTORS 12119 CON-PV_30_12119 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_30_12119.mzXML SUBJECT_SAMPLE_FACTORS 12120 CON-PV_30_12120 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_30_12120.mzXML SUBJECT_SAMPLE_FACTORS 12126 CON-PV_45_12126 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_45_12126.mzXML SUBJECT_SAMPLE_FACTORS 12127 CON-PV_45_12127 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_45_12127.mzXML SUBJECT_SAMPLE_FACTORS 12128 CON-PV_45_12128 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_45_12128.mzXML SUBJECT_SAMPLE_FACTORS 12129 CON-PV_45_12129 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_45_12129.mzXML SUBJECT_SAMPLE_FACTORS 12130 CON-PV_45_12130 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_45_12130.mzXML SUBJECT_SAMPLE_FACTORS 12136 CON-PV_60_12136 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_60_12136.mzXML SUBJECT_SAMPLE_FACTORS 12137 CON-PV_60_12137 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_60_12137.mzXML SUBJECT_SAMPLE_FACTORS 12138 CON-PV_60_12138 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_60_12138.mzXML SUBJECT_SAMPLE_FACTORS 12139 CON-PV_60_12139 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_60_12139.mzXML SUBJECT_SAMPLE_FACTORS 12140 CON-PV_60_12140 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_60_12140.mzXML SUBJECT_SAMPLE_FACTORS 12146 CON-PV_90_12146 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_90_12146.mzXML SUBJECT_SAMPLE_FACTORS 12147 CON-PV_90_12147 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_90_12147.mzXML SUBJECT_SAMPLE_FACTORS 12148 CON-PV_90_12148 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=CON-PV_90_12148.mzXML SUBJECT_SAMPLE_FACTORS 12071 H12071 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=H12071.mzXML SUBJECT_SAMPLE_FACTORS 12091 H12091 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=H12091.mzXML SUBJECT_SAMPLE_FACTORS 12092 H12092 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=H12092.mzXML SUBJECT_SAMPLE_FACTORS 12093 H12093 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=H12093.mzXML SUBJECT_SAMPLE_FACTORS 12094 H12094 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=H12094.mzXML SUBJECT_SAMPLE_FACTORS 12095 H12095 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=H12095.mzXML SUBJECT_SAMPLE_FACTORS 12121 H12121_45_02 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H12121_45_02.mzXML SUBJECT_SAMPLE_FACTORS 12122 H12122_45_02 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H12122_45_02.mzXML SUBJECT_SAMPLE_FACTORS 12124 H12124_45_02 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H12124_45_02.mzXML SUBJECT_SAMPLE_FACTORS 12125 H12125_45_02 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H12125_45_02.mzXML SUBJECT_SAMPLE_FACTORS 12131 H12131_60_03 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H12131_60_03.mzXML SUBJECT_SAMPLE_FACTORS 12132 H12132_60_03 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H12132_60_03.mzXML SUBJECT_SAMPLE_FACTORS 12134 H12134_60_03 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H12134_60_03.mzXML SUBJECT_SAMPLE_FACTORS 12135 H12135_60_03 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H12135_60_03.mzXML SUBJECT_SAMPLE_FACTORS 13151 H13151_0_01 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H13151_0_01.mzXML SUBJECT_SAMPLE_FACTORS 13152 H13152_0_01 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H13152_0_01.mzXML SUBJECT_SAMPLE_FACTORS 13153 H13153_0_01 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H13153_0_01.mzXML SUBJECT_SAMPLE_FACTORS 13154 H13154_0_01 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=H13154_0_01.mzXML SUBJECT_SAMPLE_FACTORS 13151 HFD-HV_0_13151 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_0_13151.mzXML SUBJECT_SAMPLE_FACTORS 13152 HFD-HV_0_13152 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_0_13152.mzXML SUBJECT_SAMPLE_FACTORS 13153 HFD-HV_0_13153 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_0_13153.mzXML SUBJECT_SAMPLE_FACTORS 12151 HFD-HV_120_12151 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_120_12151.mzXML SUBJECT_SAMPLE_FACTORS 12152 HFD-HV_120_12152 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_120_12152.mzXML SUBJECT_SAMPLE_FACTORS 12153 HFD-HV_120_12153 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_120_12153.mzXML SUBJECT_SAMPLE_FACTORS 12101 HFD-HV_15_12101 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_15_12101.mzXML SUBJECT_SAMPLE_FACTORS 12102 HFD-HV_15_12102 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_15_12102.mzXML SUBJECT_SAMPLE_FACTORS 12103 HFD-HV_15_12103 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_15_12103.mzXML SUBJECT_SAMPLE_FACTORS 12104 HFD-HV_15_12104 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_15_12104.mzXML SUBJECT_SAMPLE_FACTORS 12105 HFD-HV_15_12105 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_15_12105.mzXML SUBJECT_SAMPLE_FACTORS 12121 HFD-HV_30_12121 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_30_12121.mzXML SUBJECT_SAMPLE_FACTORS 12122 HFD-HV_30_12122 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_30_12122.mzXML SUBJECT_SAMPLE_FACTORS 12123 HFD-HV_30_12123 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_30_12123.mzXML SUBJECT_SAMPLE_FACTORS 12124 HFD-HV_30_12124 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_30_12124.mzXML SUBJECT_SAMPLE_FACTORS 12125 HFD-HV_30_12125 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_30_12125.mzXML SUBJECT_SAMPLE_FACTORS 12121 HFD-HV_45_12121 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_45_12121.mzXML SUBJECT_SAMPLE_FACTORS 12122 HFD-HV_45_12122 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_45_12122.mzXML SUBJECT_SAMPLE_FACTORS 12123 HFD-HV_45_12123 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_45_12123.mzXML SUBJECT_SAMPLE_FACTORS 12124 HFD-HV_45_12124 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_45_12124.mzXML SUBJECT_SAMPLE_FACTORS 12125 HFD-HV_45_12125 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_45_12125.mzXML SUBJECT_SAMPLE_FACTORS 12121 HFD-HV_60_12121 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_60_12121.mzXML SUBJECT_SAMPLE_FACTORS 12122 HFD-HV_60_12122 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_60_12122.mzXML SUBJECT_SAMPLE_FACTORS 12123 HFD-HV_60_12123 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_60_12123.mzXML SUBJECT_SAMPLE_FACTORS 12124 HFD-HV_60_12124 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_60_12124.mzXML SUBJECT_SAMPLE_FACTORS 12125 HFD-HV_60_12125 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_60_12125.mzXML SUBJECT_SAMPLE_FACTORS 12141 HFD-HV_90_12141 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_90_12141.mzXML SUBJECT_SAMPLE_FACTORS 12142 HFD-HV_90_12142 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_90_12142.mzXML SUBJECT_SAMPLE_FACTORS 12143 HFD-HV_90_12143 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-HV_90_12143.mzXML SUBJECT_SAMPLE_FACTORS 13151 HFD-PV_0_13151 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_0_13151.mzXML SUBJECT_SAMPLE_FACTORS 13152 HFD-PV_0_13152 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_0_13152.mzXML SUBJECT_SAMPLE_FACTORS 13153 HFD-PV_0_13153 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_0_13153.mzXML SUBJECT_SAMPLE_FACTORS 12151 HFD-PV_120_12151 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_120_12151.mzXML SUBJECT_SAMPLE_FACTORS 12152 HFD-PV_120_12152 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_120_12152.mzXML SUBJECT_SAMPLE_FACTORS 12153 HFD-PV_120_12153 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_120_12153.mzXML SUBJECT_SAMPLE_FACTORS 12101 HFD-PV_15_12101 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_15_12101.mzXML SUBJECT_SAMPLE_FACTORS 12102 HFD-PV_15_12102 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_15_12102.mzXML SUBJECT_SAMPLE_FACTORS 12103 HFD-PV_15_12103 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_15_12103.mzXML SUBJECT_SAMPLE_FACTORS 12104 HFD-PV_15_12104 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_15_12104.mzXML SUBJECT_SAMPLE_FACTORS 12105 HFD-PV_15_12105 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_15_12105.mzXML SUBJECT_SAMPLE_FACTORS 12121 HFD-PV_30_12121 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_30_12121.mzXML SUBJECT_SAMPLE_FACTORS 12122 HFD-PV_30_12122 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_30_12122.mzXML SUBJECT_SAMPLE_FACTORS 12123 HFD-PV_30_12123 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_30_12123.mzXML SUBJECT_SAMPLE_FACTORS 12124 HFD-PV_30_12124 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_30_12124.mzXML SUBJECT_SAMPLE_FACTORS 12125 HFD-PV_30_12125 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=4; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_30_12125.mzXML SUBJECT_SAMPLE_FACTORS 12121 HFD-PV_45_12121 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_45_12121.mzXML SUBJECT_SAMPLE_FACTORS 12122 HFD-PV_45_12122 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_45_12122.mzXML SUBJECT_SAMPLE_FACTORS 12123 HFD-PV_45_12123 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_45_12123.mzXML SUBJECT_SAMPLE_FACTORS 12124 HFD-PV_45_12124 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_45_12124.mzXML SUBJECT_SAMPLE_FACTORS 12125 HFD-PV_45_12125 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_45_12125.mzXML SUBJECT_SAMPLE_FACTORS 12121 HFD-PV_60_12121 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_60_12121.mzXML SUBJECT_SAMPLE_FACTORS 12122 HFD-PV_60_12122 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_60_12122.mzXML SUBJECT_SAMPLE_FACTORS 12123 HFD-PV_60_12123 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_60_12123.mzXML SUBJECT_SAMPLE_FACTORS 12124 HFD-PV_60_12124 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_60_12124.mzXML SUBJECT_SAMPLE_FACTORS 12125 HFD-PV_60_12125 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=3; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_60_12125.mzXML SUBJECT_SAMPLE_FACTORS 12141 HFD-PV_90_12141 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_90_12141.mzXML SUBJECT_SAMPLE_FACTORS 12142 HFD-PV_90_12142 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_90_12142.mzXML SUBJECT_SAMPLE_FACTORS 12143 HFD-PV_90_12143 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=5; Experiment=LC-MS; RAW_FILE_NAME=HFD-PV_90_12143.mzXML SUBJECT_SAMPLE_FACTORS 7596 HV_7596 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=HV_7596.mzXML SUBJECT_SAMPLE_FACTORS 7597 HV_7597 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=HV_7597.mzXML SUBJECT_SAMPLE_FACTORS 931 HV_931 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=HV_931.mzXML SUBJECT_SAMPLE_FACTORS 932 HV_932 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=HV_932.mzXML SUBJECT_SAMPLE_FACTORS 933 HV_933 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=HV_933.mzXML SUBJECT_SAMPLE_FACTORS 934 HV_934 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=HV_934.mzXML SUBJECT_SAMPLE_FACTORS 935 HV_935 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=HV_935.mzXML SUBJECT_SAMPLE_FACTORS 937 HV_937 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=HV_937.mzXML SUBJECT_SAMPLE_FACTORS 938 HV_938 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=HV_938.mzXML SUBJECT_SAMPLE_FACTORS 939 HV_939 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=HV_939.mzXML SUBJECT_SAMPLE_FACTORS Intestine_01 Intestine_01 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=13; Experiment=LC-MS; RAW_FILE_NAME=Intestine_01.mzXML SUBJECT_SAMPLE_FACTORS 931 Jej_Group1_931 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Jej_Group1_931.mzXML SUBJECT_SAMPLE_FACTORS 932 Jej_Group1_932 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Jej_Group1_932.mzXML SUBJECT_SAMPLE_FACTORS 933 Jej_Group1_933 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Jej_Group1_933.mzXML SUBJECT_SAMPLE_FACTORS 934 Jej_Group1_934 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Jej_Group1_934.mzXML SUBJECT_SAMPLE_FACTORS 935 Jej_Group1_935 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Jej_Group1_935.mzXML SUBJECT_SAMPLE_FACTORS 7596 Jej_Group2_7596 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Jej_Group2_7596.mzXML SUBJECT_SAMPLE_FACTORS 7597 Jej_Group2_7597 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Jej_Group2_7597.mzXML SUBJECT_SAMPLE_FACTORS 937 Jej_Group2_937 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Jej_Group2_937.mzXML SUBJECT_SAMPLE_FACTORS 938 Jej_Group2_938 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Jej_Group2_938.mzXML SUBJECT_SAMPLE_FACTORS 939 Jej_Group2_939 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Jej_Group2_939.mzXML SUBJECT_SAMPLE_FACTORS 13163 Jej-13163 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=1; Experiment=LC-MS; RAW_FILE_NAME=Jej-13163.mzXML SUBJECT_SAMPLE_FACTORS 13166 Jej-13166 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=1; Experiment=LC-MS; RAW_FILE_NAME=Jej-13166.mzXML SUBJECT_SAMPLE_FACTORS 13167 Jej-13167 Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=1; Experiment=LC-MS; RAW_FILE_NAME=Jej-13167.mzXML SUBJECT_SAMPLE_FACTORS 13170 Jej-13170 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=1; Experiment=LC-MS; RAW_FILE_NAME=Jej-13170.mzXML SUBJECT_SAMPLE_FACTORS 13171 Jej-13171 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=1; Experiment=LC-MS; RAW_FILE_NAME=Jej-13171.mzXML SUBJECT_SAMPLE_FACTORS 13172 Jej-13172 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water Batch=1; Experiment=LC-MS; RAW_FILE_NAME=Jej-13172.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_1 KHK_Gly_1_000 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_1_000.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_1 KHK_Gly_1_010 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_1_010.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_1 KHK_Gly_1_030 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_1_030.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_1 KHK_Gly_1_060 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_1_060.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_1 KHK_Gly_1_120 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_1_120.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_2 KHK_Gly_2_000 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_2_000.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_2 KHK_Gly_2_010 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_2_010.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_2 KHK_Gly_2_030 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_2_030.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_2 KHK_Gly_2_060 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_2_060.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_2 KHK_Gly_2_120 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_2_120.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_3 KHK_Gly_3_000 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_3_000.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_3 KHK_Gly_3_010 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_3_010.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_3 KHK_Gly_3_030 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_3_030.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_3 KHK_Gly_3_060 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_3_060.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_3 KHK_Gly_3_120 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_3_120.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_4 KHK_Gly_4_000 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_4_000.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_4 KHK_Gly_4_010 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_4_010.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_4 KHK_Gly_4_030 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_4_030.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_4 KHK_Gly_4_060 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_4_060.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_4 KHK_Gly_4_120 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_4_120.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_5 KHK_Gly_5_000 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_5_000.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_5 KHK_Gly_5_010 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_5_010.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_5 KHK_Gly_5_030 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_5_030.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_5 KHK_Gly_5_060 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_5_060.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_5 KHK_Gly_5_120 Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_5_120.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_6 KHK_Gly_6_000 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_6_000.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_6 KHK_Gly_6_010 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_6_010.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_6 KHK_Gly_6_030 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_6_030.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_6 KHK_Gly_6_060 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_6_060.mzXML SUBJECT_SAMPLE_FACTORS KHK_Gly_6 KHK_Gly_6_120 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water Batch=12; Experiment=LC-MS; RAW_FILE_NAME=KHK_Gly_6_120.mzXML SUBJECT_SAMPLE_FACTORS 12086 L12086 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=L12086.mzXML SUBJECT_SAMPLE_FACTORS 12096 L12096 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=L12096.mzXML SUBJECT_SAMPLE_FACTORS 12097 L12097 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=L12097.mzXML SUBJECT_SAMPLE_FACTORS 12098 L12098 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=L12098.mzXML SUBJECT_SAMPLE_FACTORS 12099 L12099 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=L12099.mzXML SUBJECT_SAMPLE_FACTORS 12100 L12100 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water Batch=8; Experiment=LC-MS; RAW_FILE_NAME=L12100.mzXML SUBJECT_SAMPLE_FACTORS 12126 L12126_45_02 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L12126_45_02.mzXML SUBJECT_SAMPLE_FACTORS 12128 L12128_45_02 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L12128_45_02.mzXML SUBJECT_SAMPLE_FACTORS 12129 L12129_45_02 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L12129_45_02.mzXML SUBJECT_SAMPLE_FACTORS 12130 L12130_45_02 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L12130_45_02.mzXML SUBJECT_SAMPLE_FACTORS 12136 L12136_60_03 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L12136_60_03.mzXML SUBJECT_SAMPLE_FACTORS 12137 L12137_60_03 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L12137_60_03.mzXML SUBJECT_SAMPLE_FACTORS 12139 L12139_60_03 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L12139_60_03.mzXML SUBJECT_SAMPLE_FACTORS 12140 L12140_60_03 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L12140_60_03.mzXML SUBJECT_SAMPLE_FACTORS 13156 L13156_0_01 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L13156_0_01.mzXML SUBJECT_SAMPLE_FACTORS 13157 L13157_0_01 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L13157_0_01.mzXML SUBJECT_SAMPLE_FACTORS 13159 L13159_0_01 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L13159_0_01.mzXML SUBJECT_SAMPLE_FACTORS 13160 L13160_0_01 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Batch=13; Experiment=MSI; RAW_FILE_NAME=L13160_0_01.mzXML SUBJECT_SAMPLE_FACTORS 931 Liver_Group1_931 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Liver_Group1_931.mzXML SUBJECT_SAMPLE_FACTORS 932 Liver_Group1_932 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Liver_Group1_932.mzXML SUBJECT_SAMPLE_FACTORS 933 Liver_Group1_933 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Liver_Group1_933.mzXML SUBJECT_SAMPLE_FACTORS 934 Liver_Group1_934 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Liver_Group1_934.mzXML SUBJECT_SAMPLE_FACTORS 935 Liver_Group1_935 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Liver_Group1_935.mzXML SUBJECT_SAMPLE_FACTORS 7596 Liver_Group2_7596 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Liver_Group2_7596.mzXML SUBJECT_SAMPLE_FACTORS 7597 Liver_Group2_7597 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Liver_Group2_7597.mzXML SUBJECT_SAMPLE_FACTORS 937 Liver_Group2_937 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Liver_Group2_937.mzXML SUBJECT_SAMPLE_FACTORS 938 Liver_Group2_938 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Liver_Group2_938.mzXML SUBJECT_SAMPLE_FACTORS 939 Liver_Group2_939 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water Batch=2; Experiment=LC-MS; RAW_FILE_NAME=Liver_Group2_939.mzXML SUBJECT_SAMPLE_FACTORS Ms1 Ms1_T0 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms1_T0.mzXML SUBJECT_SAMPLE_FACTORS Ms1 Ms1_T15 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms1_T15.mzXML SUBJECT_SAMPLE_FACTORS Ms1 Ms1_T45 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms1_T45.mzXML SUBJECT_SAMPLE_FACTORS Ms1 Ms1_T90 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms1_T90.mzXML SUBJECT_SAMPLE_FACTORS Ms1 Ms10_T0 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water Batch=10; Experiment=LC-MS; RAW_FILE_NAME=Ms10_T0.mzXML SUBJECT_SAMPLE_FACTORS Ms1 Ms10_T120 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=10; Experiment=LC-MS; RAW_FILE_NAME=Ms10_T120.mzXML SUBJECT_SAMPLE_FACTORS Ms1 Ms10_T30 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=10; Experiment=LC-MS; RAW_FILE_NAME=Ms10_T30.mzXML SUBJECT_SAMPLE_FACTORS Ms1 Ms10_T60 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=10; Experiment=LC-MS; RAW_FILE_NAME=Ms10_T60.mzXML SUBJECT_SAMPLE_FACTORS Ms2 Ms2_T0 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms2_T0.mzXML SUBJECT_SAMPLE_FACTORS Ms2 Ms2_T15 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms2_T15.mzXML SUBJECT_SAMPLE_FACTORS Ms2 Ms2_T45 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms2_T45.mzXML SUBJECT_SAMPLE_FACTORS Ms2 Ms2_T90 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms2_T90.mzXML SUBJECT_SAMPLE_FACTORS Ms3 Ms3_T0 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms3_T0.mzXML SUBJECT_SAMPLE_FACTORS Ms3 Ms3_T15 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms3_T15.mzXML SUBJECT_SAMPLE_FACTORS Ms3 Ms3_T45 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms3_T45.mzXML SUBJECT_SAMPLE_FACTORS Ms3 Ms3_T90 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms3_T90.mzXML SUBJECT_SAMPLE_FACTORS Ms4 Ms4_T0 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms4_T0.mzXML SUBJECT_SAMPLE_FACTORS Ms4 Ms4_T15 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms4_T15.mzXML SUBJECT_SAMPLE_FACTORS Ms4 Ms4_T45 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms4_T45.mzXML SUBJECT_SAMPLE_FACTORS Ms4 Ms4_T90 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms4_T90.mzXML SUBJECT_SAMPLE_FACTORS Ms5 Ms5_T0 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water Batch=10; Experiment=LC-MS; RAW_FILE_NAME=Ms5_T0.mzXML SUBJECT_SAMPLE_FACTORS Ms5 Ms5_T15 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):15 | Drinking:Water Batch=10; Experiment=LC-MS; RAW_FILE_NAME=Ms5_T15.mzXML SUBJECT_SAMPLE_FACTORS Ms5 Ms5_T45 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):45 | Drinking:Water Batch=10; Experiment=LC-MS; RAW_FILE_NAME=Ms5_T45.mzXML SUBJECT_SAMPLE_FACTORS Ms5 Ms5_T90 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):90 | Drinking:Water Batch=10; Experiment=LC-MS; RAW_FILE_NAME=Ms5_T90.mzXML SUBJECT_SAMPLE_FACTORS Ms6 Ms6_T0 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms6_T0.mzXML SUBJECT_SAMPLE_FACTORS Ms6 Ms6_T120 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms6_T120.mzXML SUBJECT_SAMPLE_FACTORS Ms6 Ms6_T30 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms6_T30.mzXML SUBJECT_SAMPLE_FACTORS Ms6 Ms6_T60 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms6_T60.mzXML SUBJECT_SAMPLE_FACTORS Ms7 Ms7_T0 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms7_T0.mzXML SUBJECT_SAMPLE_FACTORS Ms7 Ms7_T120 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms7_T120.mzXML SUBJECT_SAMPLE_FACTORS Ms7 Ms7_T30 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms7_T30.mzXML SUBJECT_SAMPLE_FACTORS Ms7 Ms7_T60 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms7_T60.mzXML SUBJECT_SAMPLE_FACTORS Ms8 Ms8_T0 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms8_T0.mzXML SUBJECT_SAMPLE_FACTORS Ms8 Ms8_T120 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms8_T120.mzXML SUBJECT_SAMPLE_FACTORS Ms8 Ms8_T30 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms8_T30.mzXML SUBJECT_SAMPLE_FACTORS Ms8 Ms8_T60 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms8_T60.mzXML SUBJECT_SAMPLE_FACTORS Ms9 Ms9_T0 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms9_T0.mzXML SUBJECT_SAMPLE_FACTORS Ms9 Ms9_T120 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):120 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms9_T120.mzXML SUBJECT_SAMPLE_FACTORS Ms9 Ms9_T30 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):30 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms9_T30.mzXML SUBJECT_SAMPLE_FACTORS Ms9 Ms9_T60 Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):60 | Drinking:Water Batch=9; Experiment=LC-MS; RAW_FILE_NAME=Ms9_T60.mzXML SUBJECT_SAMPLE_FACTORS 7596 PV_7596 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=PV_7596.mzXML SUBJECT_SAMPLE_FACTORS 7597 PV_7597 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=PV_7597.mzXML SUBJECT_SAMPLE_FACTORS 931 PV_931 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=PV_931.mzXML SUBJECT_SAMPLE_FACTORS 932 PV_932 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=PV_932.mzXML SUBJECT_SAMPLE_FACTORS 933 PV_933 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=PV_933.mzXML SUBJECT_SAMPLE_FACTORS 934 PV_934 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=PV_934.mzXML SUBJECT_SAMPLE_FACTORS 935 PV_935 Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=PV_935.mzXML SUBJECT_SAMPLE_FACTORS 937 PV_937 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=PV_937.mzXML SUBJECT_SAMPLE_FACTORS 938 PV_938 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=PV_938.mzXML SUBJECT_SAMPLE_FACTORS 939 PV_939 Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water Batch=7; Experiment=LC-MS; RAW_FILE_NAME=PV_939.mzXML SUBJECT_SAMPLE_FACTORS 13634 Unlabeled_LC-HV_13634 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LC-HV_13634.mzXML SUBJECT_SAMPLE_FACTORS 13635 Unlabeled_LC-HV_13635 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LC-HV_13635.mzXML SUBJECT_SAMPLE_FACTORS 13637 Unlabeled_LC-HV_13637 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LC-HV_13637.mzXML SUBJECT_SAMPLE_FACTORS 13642 Unlabeled_LC-HV_13642 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LC-HV_13642.mzXML SUBJECT_SAMPLE_FACTORS 13646 Unlabeled_LC-HV_13646 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LC-HV_13646.mzXML SUBJECT_SAMPLE_FACTORS 13683 Unlabeled_LC-HV_13683 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LC-HV_13683.mzXML SUBJECT_SAMPLE_FACTORS 13626 Unlabeled_LF-HV_13626 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LF-HV_13626.mzXML SUBJECT_SAMPLE_FACTORS 13627 Unlabeled_LF-HV_13627 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LF-HV_13627.mzXML SUBJECT_SAMPLE_FACTORS 13628 Unlabeled_LF-HV_13628 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LF-HV_13628.mzXML SUBJECT_SAMPLE_FACTORS 13631 Unlabeled_LF-HV_13631 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LF-HV_13631.mzXML SUBJECT_SAMPLE_FACTORS 6348 Unlabeled_LF-HV_6348 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LF-HV_6348.mzXML SUBJECT_SAMPLE_FACTORS 10632 Unlabeled_LH-HV_10632 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LH-HV_10632.mzXML SUBJECT_SAMPLE_FACTORS 10684 Unlabeled_LH-HV_10684 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LH-HV_10684.mzXML SUBJECT_SAMPLE_FACTORS 914 Unlabeled_LH-HV_914 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LH-HV_914.mzXML SUBJECT_SAMPLE_FACTORS 916 Unlabeled_LH-HV_916 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LH-HV_916.mzXML SUBJECT_SAMPLE_FACTORS 917 Unlabeled_LH-HV_917 Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water Batch=11; Experiment=LC-MS; RAW_FILE_NAME=Unlabeled_LH-HV_917.mzXML #COLLECTION CO:COLLECTION_SUMMARY After 3 days or 4 weeks of either HFD or CD feeding, each mouse was CO:COLLECTION_SUMMARY administrated a 1g/kg U-13C fructose oral gavage. Mice were anesthetized with 2% CO:COLLECTION_SUMMARY isoflurane, and their abdominal cavities were opened at the specified time. CO:COLLECTION_SUMMARY Abdominal tissues were displaced to identify the portal vein, and a 27G needle CO:COLLECTION_SUMMARY was used to immediately collect portal vein blood samples (~100 µL). CO:COLLECTION_SUMMARY Immediately after, cardiac blood was collected from the right ventricle using a CO:COLLECTION_SUMMARY 25G needle (~1 mL). The jejunum, pancreas, and liver tissues were quickly CO:COLLECTION_SUMMARY resected and snap-frozen in liquid nitrogen. Blood samples were placed on ice in CO:COLLECTION_SUMMARY the absence of anticoagulant for 20 minutes and centrifuged at 16,000 × g for CO:COLLECTION_SUMMARY 10 minutes at 4 °C to separate the serum and plasma fractions of each sample. CO:COLLECTION_SUMMARY Serum and tissue samples were kept at −80 °C until further analysis. CO:COLLECTION_PROTOCOL_FILENAME cwwong_methods.pdf CO:SAMPLE_TYPE Tissue #TREATMENT TR:TREATMENT_SUMMARY After 3 days or 4 weeks of either HFD or CD feeding, each mouse was TR:TREATMENT_SUMMARY administrated a 1g/kg U-13C fructose oral gavage. For ad-lib fructose feeding TR:TREATMENT_SUMMARY experiments, mice were fed fructose in the drinking water (15% w/v) for 4 weeks. TR:TREATMENT_SUMMARY Saline, fructose and glycerate injection were done in CD-fed mice for 12 weeks. TR:TREATMENT_SUMMARY For glycerate kinetic study, glycerate injections were performed in TR:TREATMENT_SUMMARY treatment-navie mice. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY For LC-MS: Metabolites were extracted using a protocol optimized for SP:SAMPLEPREP_SUMMARY water-soluble polar metabolite analysis using liquid chromatography coupled with SP:SAMPLEPREP_SUMMARY mass spectrometry. All extraction buffers were stored at -20°C prior to usage SP:SAMPLEPREP_SUMMARY and immediately preceding the metabolite extraction. For serum samples, a 10 μL SP:SAMPLEPREP_SUMMARY serum aliquot was used for fructose tracing. Metabolites were extracted with 40 SP:SAMPLEPREP_SUMMARY μL of ice-cold methanol and incubated at -20 °C for 20 minutes. The clean SP:SAMPLEPREP_SUMMARY supernatant was collected after centrifugation for 10 minutes at the highest SP:SAMPLEPREP_SUMMARY speed, and the leftover pellet was further treated with 200 µL cold extraction SP:SAMPLEPREP_SUMMARY buffer (40:40:20 v/v/v methanol:acetonitrile:water solution) and left to SP:SAMPLEPREP_SUMMARY incubate on crushed ice for an additional 10 minutes. Following an additional 10 SP:SAMPLEPREP_SUMMARY minutes of centrifugation at the highest speed, the clean supernatant was SP:SAMPLEPREP_SUMMARY collected and pooled with the supernatant from the first collection. For tissue SP:SAMPLEPREP_SUMMARY samples, the extraction buffer used was a (v/v/v) solution of 40:40:20 SP:SAMPLEPREP_SUMMARY (methanol:acetonitrile:water) + 0.1 M formic acid. An aliquot volume equivalent SP:SAMPLEPREP_SUMMARY to 20x the sample weight was added to the Eppendorf tube with the homogenized SP:SAMPLEPREP_SUMMARY sample, vortexed for 10 seconds, and left to chill on crushed ice for 10 SP:SAMPLEPREP_SUMMARY minutes. The samples were then centrifuged for 10 minutes at the highest speed SP:SAMPLEPREP_SUMMARY at 4°C. The supernatant was transferred to a correspondingly labeled and SP:SAMPLEPREP_SUMMARY chilled Eppendorf tube, and the process was repeated once more. The total volume SP:SAMPLEPREP_SUMMARY of supernatant was then centrifuged for an additional 10 minutes. After SP:SAMPLEPREP_SUMMARY centrifugation, a final 500µL aliquot of the homogenate was then pipetted to a SP:SAMPLEPREP_SUMMARY second clean Eppendorf tube, to which 44µL of 15% (m/v) NH4HCO3 was added to SP:SAMPLEPREP_SUMMARY neutralize the acid in the buffer and precipitate the protein. This is the final SP:SAMPLEPREP_SUMMARY sample extract to be vialed and loaded to the instrument for analysis. SP:SAMPLEPREP_SUMMARY Metabolite extracts were stored at -80 °C until analysis. For MSI: Pancreas SP:SAMPLEPREP_SUMMARY tissues were first equilibrated to -15°C then sectioned to 20 µm thickness SP:SAMPLEPREP_SUMMARY using a Leica CM1950 cryostat (Buffalo Grove, IL, USA). Cut sections were then SP:SAMPLEPREP_SUMMARY thaw-mounted on clean microscope slides (1 mm height, plain, Fisher Scientific, SP:SAMPLEPREP_SUMMARY Pittsburgh, PA) and stored at -80 °C until IR-MALDESI-MSI analysis. Tissues SP:SAMPLEPREP_SUMMARY were first blocked into four groups, each containing one replicate of each SP:SAMPLEPREP_SUMMARY condition. Tissues were both cut and imaged in randomized order within these SP:SAMPLEPREP_SUMMARY blocks to minimize sampling bias. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE IR-MALD CH:INSTRUMENT_NAME Other CH:COLUMN_NAME Other #ANALYSIS AN:ANALYSIS_TYPE MS AN:ANALYSIS_PROTOCOL_FILE cwwong_methods.pdf #MS MS:INSTRUMENT_NAME Thermo Exploris 240 Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS To ablate targeted tissue regions a 2970-nm wavelength laser was used with a MS:MS_COMMENTS single burst of ten pulses to produce 1 mJ of energy at a rate of 10 kHz. X and MS:MS_COMMENTS Y stage movements of 100 µm were used to achieve oversampling(Nazari and MS:MS_COMMENTS Muddiman, 2015). Ablated analytes were post-ionized in the orthogonal MS:MS_COMMENTS electrospray plume, established by applying a voltage of approximately 3 kV to MS:MS_COMMENTS the electrospray solvent (1 mM acetic acid in 50:50 water/acetonitrile.) Mass MS:MS_COMMENTS spectrometry analysis of ionized molecules was performed in negative mode with MS:MS_COMMENTS internal calibrant used to achieve high mass accuracy (<2.5 ppm) within the MS:MS_COMMENTS 85-225 m/z range. Automatic gain control (AGC) was disabled. A mass resolution MS:MS_COMMENTS power of 240,000FWHM at 200 m/z was used with a fixed injection time (15 ms) to MS:MS_COMMENTS synchronize timing of the ablation plume with ion collection in the C-trap of MS:MS_COMMENTS the mass spectrometer. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Total Abundance MS_METABOLITE_DATA_START Samples L13156_0_01 L13157_0_01 L13159_0_01 L13160_0_01 L12126_45_02 L12128_45_02 L12129_45_02 L12130_45_02 L12136_60_03 L12137_60_03 L12139_60_03 L12140_60_03 H13151_0_01 H13152_0_01 H13153_0_01 H13154_0_01 H12121_45_02 H12122_45_02 H12124_45_02 H12125_45_02 H12131_60_03 H12132_60_03 H12134_60_03 H12135_60_03 Factors Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water Glycerate_M3 0 0 0 2285.226 2390.653 0 1817.72 2212.547 1909.868 3561.453 1610.784 2320.173 0 1603.791 1727.108 0 2284.242 1910.462 2340.831 1830.826 2384.841 3046.632 2238.792 1934.911 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Compound Label Glycerate_M3 Glycerate 3 METABOLITES_END #END