{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002183","ANALYSIS_ID":"AN003576","VERSION":"1","CREATED_ON":"June 1, 2022, 9:31 pm"},

"PROJECT":{"PROJECT_TITLE":"Individualized exercise intervention for people with multiple myeloma improves quality of life in a randomized controlled trial","PROJECT_TYPE":"MS untargeted metabolomics analysis","PROJECT_SUMMARY":"Although new treatments have improved survival for multiple myeloma (MM), quality of life remains poor for people with this incurable cancer. We conducted a multi-site randomized, waitlist-controlled trial of an individualized exercise program for people at all stages of MM (n=60). Compared to the waitlist control group, participants of the 12-week intervention had significant improvement in health-related quality of life, mediated through improved MM symptoms, cardiorespiratory fitness and bone pain, with were mostly maintained at follow-up (up to 12 months). Exploratory plasma metabolomics and lipidomics was conducted to delineate molecular mechanisms and biomarkers","INSTITUTE":"QIMR Berghofer Medical Research Institute","LABORATORY":"Precision & Systems Biomedicine","LAST_NAME":"Stoll","FIRST_NAME":"Thomas","ADDRESS":"300 Herston Road, Herston, Queensland, 4006, Australia","EMAIL":"thomas.stoll@qimrberghofer.edu.au","PHONE":"+61 7 3845 3992"},

"STUDY":{"STUDY_TITLE":"Individualized exercise intervention for people with multiple myeloma improves quality of life in a randomized controlled trial","STUDY_SUMMARY":"Although new treatments have improved survival for multiple myeloma (MM), quality of life remains poor for people with this incurable cancer. We conducted a multi-site randomized, waitlist-controlled trial of an individualized exercise program for people at all stages of MM (n=60). Compared to the waitlist control group, participants of the 12-week intervention had significant improvement in health-related quality of life, mediated through improved MM symptoms, cardiorespiratory fitness and bone pain, with were mostly maintained at follow-up (up to 12 months). Exploratory plasma metabolomics and lipidomics was conducted to delineate molecular mechanisms and biomarkers","INSTITUTE":"QIMR Berghofer Medical Research Institute","LABORATORY":"Precision & Systems Biomedicine","LAST_NAME":"Stoll","FIRST_NAME":"Thomas","ADDRESS":"300 Herston Road","EMAIL":"thomas.stoll@qimrberghofer.edu.au","PHONE":"+61 7 3845 3992"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"MM001_0_p1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM001_0_p1_MetRPpos","RAW_FILE_NAME":"MM001_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM001_1_p1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM001_1_p1_MetRPpos","RAW_FILE_NAME":"MM001_1_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM001_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM001_2_pE1_MetRPpos","RAW_FILE_NAME":"MM001_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM001_4_pE1",
"Factors":{"Group":"waitlist","Time_point":"4"},
"Additional sample data":{"RAW_FILE_NAME":"MM001_4_pE1_MetRPpos","RAW_FILE_NAME":"MM001_4_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM002_0_p1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM002_0_p1_MetRPpos","RAW_FILE_NAME":"MM002_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM002_1_p1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM002_1_p1_MetRPpos","RAW_FILE_NAME":"MM002_1_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM003_0_p1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM003_0_p1_MetRPpos","RAW_FILE_NAME":"MM003_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM003_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM003_1_pE1_MetRPpos","RAW_FILE_NAME":"MM003_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM003_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM003_3_pE1_MetRPpos","RAW_FILE_NAME":"MM003_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM004_0_p1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM004_0_p1_MetRPpos","RAW_FILE_NAME":"MM004_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM004_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM004_1_pE1_MetRPpos","RAW_FILE_NAME":"MM004_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM004_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM004_3_pE1_MetRPpos","RAW_FILE_NAME":"MM004_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM006_0_p1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM006_0_p1_MetRPpos","RAW_FILE_NAME":"MM006_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM006_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM006_1_pE1_MetRPpos","RAW_FILE_NAME":"MM006_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM007_0_p1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM007_0_p1_MetRPpos","RAW_FILE_NAME":"MM007_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM007_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM007_1_pE1_MetRPpos","RAW_FILE_NAME":"MM007_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM007_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM007_2_pE1_MetRPpos","RAW_FILE_NAME":"MM007_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM007_4_pE1",
"Factors":{"Group":"waitlist","Time_point":"4"},
"Additional sample data":{"RAW_FILE_NAME":"MM007_4_pE1_MetRPpos","RAW_FILE_NAME":"MM007_4_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM008_0_p1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM008_0_p1_MetRPpos","RAW_FILE_NAME":"MM008_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM008_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM008_1_pE1_MetRPpos","RAW_FILE_NAME":"MM008_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM008_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM008_3_pE1_MetRPpos","RAW_FILE_NAME":"MM008_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM009_0_p1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM009_0_p1_MetRPpos","RAW_FILE_NAME":"MM009_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM009_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM009_1_pE1_MetRPpos","RAW_FILE_NAME":"MM009_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM009_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM009_2_pE1_MetRPpos","RAW_FILE_NAME":"MM009_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM009_4_pE1",
"Factors":{"Group":"waitlist","Time_point":"4"},
"Additional sample data":{"RAW_FILE_NAME":"MM009_4_pE1_MetRPpos","RAW_FILE_NAME":"MM009_4_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM010_0_p1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM010_0_p1_MetRPpos","RAW_FILE_NAME":"MM010_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM010_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM010_1_pE1_MetRPpos","RAW_FILE_NAME":"MM010_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM010_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM010_3_pE1_MetRPpos","RAW_FILE_NAME":"MM010_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM011_0_p1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM011_0_p1_MetRPpos","RAW_FILE_NAME":"MM011_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM011_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM011_1_pE1_MetRPpos","RAW_FILE_NAME":"MM011_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM011_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM011_3_pE1_MetRPpos","RAW_FILE_NAME":"MM011_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM013_0_p1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM013_0_p1_MetRPpos","RAW_FILE_NAME":"MM013_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM013_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM013_1_pE1_MetRPpos","RAW_FILE_NAME":"MM013_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM013_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM013_2_pE1_MetRPpos","RAW_FILE_NAME":"MM013_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM013_4_pE1",
"Factors":{"Group":"waitlist","Time_point":"4"},
"Additional sample data":{"RAW_FILE_NAME":"MM013_4_pE1_MetRPpos","RAW_FILE_NAME":"MM013_4_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM014_0_p1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM014_0_p1_MetRPpos","RAW_FILE_NAME":"MM014_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM014_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM014_1_pE1_MetRPpos","RAW_FILE_NAME":"MM014_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM014_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM014_3_pE1_MetRPpos","RAW_FILE_NAME":"MM014_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM017_0_p2",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM017_0_p2_MetRPpos","RAW_FILE_NAME":"MM017_0_p2_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM017_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM017_1_pE1_MetRPpos","RAW_FILE_NAME":"MM017_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM017_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM017_2_pE1_MetRPpos","RAW_FILE_NAME":"MM017_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM017_4_pE1",
"Factors":{"Group":"waitlist","Time_point":"4"},
"Additional sample data":{"RAW_FILE_NAME":"MM017_4_pE1_MetRPpos","RAW_FILE_NAME":"MM017_4_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM018_0_p1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM018_0_p1_MetRPpos","RAW_FILE_NAME":"MM018_0_p1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM018_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM018_1_pE1_MetRPpos","RAW_FILE_NAME":"MM018_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM019_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM019_0_pE1_MetRPpos","RAW_FILE_NAME":"MM019_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM019_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM019_1_pE1_MetRPpos","RAW_FILE_NAME":"MM019_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM019_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM019_2_pE1_MetRPpos","RAW_FILE_NAME":"MM019_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM019_4_pE1",
"Factors":{"Group":"waitlist","Time_point":"4"},
"Additional sample data":{"RAW_FILE_NAME":"MM019_4_pE1_MetRPpos","RAW_FILE_NAME":"MM019_4_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM020_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM020_0_pE1_MetRPpos","RAW_FILE_NAME":"MM020_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM020_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM020_1_pE1_MetRPpos","RAW_FILE_NAME":"MM020_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM021_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM021_0_pE1_MetRPpos","RAW_FILE_NAME":"MM021_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM021_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM021_1_pE1_MetRPpos","RAW_FILE_NAME":"MM021_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM021_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM021_2_pE1_MetRPpos","RAW_FILE_NAME":"MM021_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM022_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM022_0_pE1_MetRPpos","RAW_FILE_NAME":"MM022_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM022_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM022_1_pE1_MetRPpos","RAW_FILE_NAME":"MM022_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM022_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM022_3_pE1_MetRPpos","RAW_FILE_NAME":"MM022_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM023_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM023_0_pE1_MetRPpos","RAW_FILE_NAME":"MM023_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM023_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM023_1_pE1_MetRPpos","RAW_FILE_NAME":"MM023_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM025_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM025_0_pE1_MetRPpos","RAW_FILE_NAME":"MM025_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM025_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM025_1_pE1_MetRPpos","RAW_FILE_NAME":"MM025_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM025_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM025_2_pE1_MetRPpos","RAW_FILE_NAME":"MM025_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM026_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM026_0_pE1_MetRPpos","RAW_FILE_NAME":"MM026_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM026_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM026_1_pE1_MetRPpos","RAW_FILE_NAME":"MM026_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM026_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM026_3_pE1_MetRPpos","RAW_FILE_NAME":"MM026_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM027_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM027_0_pE1_MetRPpos","RAW_FILE_NAME":"MM027_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM027_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM027_1_pE1_MetRPpos","RAW_FILE_NAME":"MM027_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM027_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM027_3_pE1_MetRPpos","RAW_FILE_NAME":"MM027_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM028_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM028_0_pE1_MetRPpos","RAW_FILE_NAME":"MM028_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM028_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM028_1_pE1_MetRPpos","RAW_FILE_NAME":"MM028_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM028_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM028_2_pE1_MetRPpos","RAW_FILE_NAME":"MM028_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM028_4_pE1",
"Factors":{"Group":"waitlist","Time_point":"4"},
"Additional sample data":{"RAW_FILE_NAME":"MM028_4_pE1_MetRPpos","RAW_FILE_NAME":"MM028_4_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM030_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM030_0_pE1_MetRPpos","RAW_FILE_NAME":"MM030_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM030_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM030_1_pE1_MetRPpos","RAW_FILE_NAME":"MM030_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM030_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM030_2_pE1_MetRPpos","RAW_FILE_NAME":"MM030_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM032_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM032_0_pE1_MetRPpos","RAW_FILE_NAME":"MM032_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM032_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM032_1_pE1_MetRPpos","RAW_FILE_NAME":"MM032_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM033_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM033_0_pE1_MetRPpos","RAW_FILE_NAME":"MM033_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM033_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM033_1_pE1_MetRPpos","RAW_FILE_NAME":"MM033_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM033_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM033_2_pE1_MetRPpos","RAW_FILE_NAME":"MM033_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM035_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM035_0_pE1_MetRPpos","RAW_FILE_NAME":"MM035_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM035_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM035_1_pE1_MetRPpos","RAW_FILE_NAME":"MM035_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM035_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM035_3_pE1_MetRPpos","RAW_FILE_NAME":"MM035_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM036_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM036_0_pE1_MetRPpos","RAW_FILE_NAME":"MM036_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM036_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM036_1_pE1_MetRPpos","RAW_FILE_NAME":"MM036_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM036_3_pE1",
"Factors":{"Group":"exercise","Time_point":"3"},
"Additional sample data":{"RAW_FILE_NAME":"MM036_3_pE1_MetRPpos","RAW_FILE_NAME":"MM036_3_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM037_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM037_0_pE1_MetRPpos","RAW_FILE_NAME":"MM037_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM037_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM037_1_pE1_MetRPpos","RAW_FILE_NAME":"MM037_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM037_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM037_2_pE1_MetRPpos","RAW_FILE_NAME":"MM037_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM037_4_pE1",
"Factors":{"Group":"waitlist","Time_point":"4"},
"Additional sample data":{"RAW_FILE_NAME":"MM037_4_pE1_MetRPpos","RAW_FILE_NAME":"MM037_4_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM039_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM039_0_pE1_MetRPpos","RAW_FILE_NAME":"MM039_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM039_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM039_1_pE1_MetRPpos","RAW_FILE_NAME":"MM039_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM040_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM040_0_pE1_MetRPpos","RAW_FILE_NAME":"MM040_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM040_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM040_1_pE1_MetRPpos","RAW_FILE_NAME":"MM040_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM041_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM041_0_pE1_MetRPpos","RAW_FILE_NAME":"MM041_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM041_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM041_1_pE1_MetRPpos","RAW_FILE_NAME":"MM041_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM043_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM043_0_pE1_MetRPpos","RAW_FILE_NAME":"MM043_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM043_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM043_1_pE1_MetRPpos","RAW_FILE_NAME":"MM043_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM043_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM043_2_pE1_MetRPpos","RAW_FILE_NAME":"MM043_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM044_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM044_0_pE1_MetRPpos","RAW_FILE_NAME":"MM044_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM044_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM044_1_pE1_MetRPpos","RAW_FILE_NAME":"MM044_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM045_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM045_0_pE1_MetRPpos","RAW_FILE_NAME":"MM045_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM045_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM045_1_pE1_MetRPpos","RAW_FILE_NAME":"MM045_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM046_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM046_0_pE1_MetRPpos","RAW_FILE_NAME":"MM046_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM046_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM046_1_pE1_MetRPpos","RAW_FILE_NAME":"MM046_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM046_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM046_2_pE1_MetRPpos","RAW_FILE_NAME":"MM046_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM047_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM047_0_pE1_MetRPpos","RAW_FILE_NAME":"MM047_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM047_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM047_1_pE1_MetRPpos","RAW_FILE_NAME":"MM047_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM047_2_pE1",
"Factors":{"Group":"waitlist","Time_point":"2"},
"Additional sample data":{"RAW_FILE_NAME":"MM047_2_pE1_MetRPpos","RAW_FILE_NAME":"MM047_2_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM049_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM049_0_pE1_MetRPpos","RAW_FILE_NAME":"MM049_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM049_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM049_1_pE1_MetRPpos","RAW_FILE_NAME":"MM049_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM050_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM050_0_pE1_MetRPpos","RAW_FILE_NAME":"MM050_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM050_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM050_1_pE1_MetRPpos","RAW_FILE_NAME":"MM050_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM051_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM051_0_pE1_MetRPpos","RAW_FILE_NAME":"MM051_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM051_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM051_1_pE1_MetRPpos","RAW_FILE_NAME":"MM051_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM054_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM054_0_pE1_MetRPpos","RAW_FILE_NAME":"MM054_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM054_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM054_1_pE1_MetRPpos","RAW_FILE_NAME":"MM054_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM055_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM055_0_pE1_MetRPpos","RAW_FILE_NAME":"MM055_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM055_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM055_1_pE1_MetRPpos","RAW_FILE_NAME":"MM055_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM056_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM056_0_pE1_MetRPpos","RAW_FILE_NAME":"MM056_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM056_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM056_1_pE1_MetRPpos","RAW_FILE_NAME":"MM056_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM057_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM057_0_pE1_MetRPpos","RAW_FILE_NAME":"MM057_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM057_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM057_1_pE1_MetRPpos","RAW_FILE_NAME":"MM057_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM058_0_pE1",
"Factors":{"Group":"exercise","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM058_0_pE1_MetRPpos","RAW_FILE_NAME":"MM058_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM058_1_pE1",
"Factors":{"Group":"exercise","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM058_1_pE1_MetRPpos","RAW_FILE_NAME":"MM058_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM059_0_pE1",
"Factors":{"Group":"waitlist","Time_point":"-"},
"Additional sample data":{"RAW_FILE_NAME":"MM059_0_pE1_MetRPpos","RAW_FILE_NAME":"MM059_0_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"MM059_1_pE1",
"Factors":{"Group":"waitlist","Time_point":"1"},
"Additional sample data":{"RAW_FILE_NAME":"MM059_1_pE1_MetRPpos","RAW_FILE_NAME":"MM059_1_pE1_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_01",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_01_MetRPpos","RAW_FILE_NAME":"QC_HP_01_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_02",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_02_MetRPpos","RAW_FILE_NAME":"QC_HP_02_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_03",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_03_MetRPpos","RAW_FILE_NAME":"QC_HP_03_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_04",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_04_MetRPpos","RAW_FILE_NAME":"QC_HP_04_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_05",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_05_MetRPpos","RAW_FILE_NAME":"QC_HP_05_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_06",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_06_MetRPpos","RAW_FILE_NAME":"QC_HP_06_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_07",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_07_MetRPpos","RAW_FILE_NAME":"QC_HP_07_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_08",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_08_MetRPpos","RAW_FILE_NAME":"QC_HP_08_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_09",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_09_MetRPpos","RAW_FILE_NAME":"QC_HP_09_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_10",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_10_MetRPpos","RAW_FILE_NAME":"QC_HP_10_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_11",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_11_MetRPpos","RAW_FILE_NAME":"QC_HP_11_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_12",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_12_MetRPpos","RAW_FILE_NAME":"QC_HP_12_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_13",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_13_MetRPpos","RAW_FILE_NAME":"QC_HP_13_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_14",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_14_MetRPpos","RAW_FILE_NAME":"QC_HP_14_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_15",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_15_MetRPpos","RAW_FILE_NAME":"QC_HP_15_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_16",
"Factors":{"Group":"QC","Time_point":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_16_MetRPpos","RAW_FILE_NAME":"QC_HP_16_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"HP_BlankNegControlExtraction_01",
"Factors":{"Group":"Blank","Time_point":"Blank"},
"Additional sample data":{"RAW_FILE_NAME":"HP_BlankNegControlExtraction_01_MetRPpos","RAW_FILE_NAME":"HP_BlankNegControlExtraction_01_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"HP_BlankNegControlExtraction_02",
"Factors":{"Group":"Blank","Time_point":"Blank"},
"Additional sample data":{"RAW_FILE_NAME":"HP_BlankNegControlExtraction_02_MetRPpos","RAW_FILE_NAME":"HP_BlankNegControlExtraction_02_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"HP_BlankNegControlExtraction_03",
"Factors":{"Group":"Blank","Time_point":"Blank"},
"Additional sample data":{"RAW_FILE_NAME":"HP_BlankNegControlExtraction_03_MetRPpos","RAW_FILE_NAME":"HP_BlankNegControlExtraction_03_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"HP_BlankNegControlExtraction_04",
"Factors":{"Group":"Blank","Time_point":"Blank"},
"Additional sample data":{"RAW_FILE_NAME":"HP_BlankNegControlExtraction_04_MetRPpos","RAW_FILE_NAME":"HP_BlankNegControlExtraction_04_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"HP_BlankNegControlExtraction_05",
"Factors":{"Group":"Blank","Time_point":"Blank"},
"Additional sample data":{"RAW_FILE_NAME":"HP_BlankNegControlExtraction_05_MetRPpos","RAW_FILE_NAME":"HP_BlankNegControlExtraction_05_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"HP_BlankNegControlExtraction_06",
"Factors":{"Group":"Blank","Time_point":"Blank"},
"Additional sample data":{"RAW_FILE_NAME":"HP_BlankNegControlExtraction_06_MetRPpos","RAW_FILE_NAME":"HP_BlankNegControlExtraction_06_MetHILICneg"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE0_it01",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE0_it01","RAW_FILE_NAME":"QC_HP_itMS2neg_CE0_it01"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE0_it02",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE0_it02","RAW_FILE_NAME":"QC_HP_itMS2neg_CE0_it02"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE0_it03",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE0_it03","RAW_FILE_NAME":"QC_HP_itMS2neg_CE0_it03"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE0_it04",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE0_it04","RAW_FILE_NAME":"QC_HP_itMS2neg_CE0_it04"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE0_it05",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE0_it05","RAW_FILE_NAME":"QC_HP_itMS2neg_CE0_it05"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE0_it06",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE0_it06","RAW_FILE_NAME":"QC_HP_itMS2neg_CE0_it06"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE0_it07",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE0_it07","RAW_FILE_NAME":"QC_HP_itMS2neg_CE0_it07"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE0_it08",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE0_it08","RAW_FILE_NAME":"QC_HP_itMS2neg_CE0_it08"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE10_it01",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE10_it01","RAW_FILE_NAME":"QC_HP_itMS2neg_CE10_it01"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE10_it02",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE10_it02","RAW_FILE_NAME":"QC_HP_itMS2neg_CE10_it02"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE10_it03",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE10_it03","RAW_FILE_NAME":"QC_HP_itMS2neg_CE10_it03"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE10_it04",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE10_it04","RAW_FILE_NAME":"QC_HP_itMS2neg_CE10_it04"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE10_it05",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE10_it05","RAW_FILE_NAME":"QC_HP_itMS2neg_CE10_it05"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE10_it06",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE10_it06","RAW_FILE_NAME":"QC_HP_itMS2neg_CE10_it06"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE10_it07",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE10_it07","RAW_FILE_NAME":"QC_HP_itMS2neg_CE10_it07"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE10_it08",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE10_it08","RAW_FILE_NAME":"QC_HP_itMS2neg_CE10_it08"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE20_it01",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE20_it01","RAW_FILE_NAME":"QC_HP_itMS2neg_CE20_it01"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE20_it02",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE20_it02","RAW_FILE_NAME":"QC_HP_itMS2neg_CE20_it02"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE20_it03",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE20_it03","RAW_FILE_NAME":"QC_HP_itMS2neg_CE20_it03"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE20_it04",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE20_it04","RAW_FILE_NAME":"QC_HP_itMS2neg_CE20_it04"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE20_it05",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE20_it05","RAW_FILE_NAME":"QC_HP_itMS2neg_CE20_it05"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE20_it06",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE20_it06","RAW_FILE_NAME":"QC_HP_itMS2neg_CE20_it06"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE20_it07",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE20_it07","RAW_FILE_NAME":"QC_HP_itMS2neg_CE20_it07"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE20_it08",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE20_it08","RAW_FILE_NAME":"QC_HP_itMS2neg_CE20_it08"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE40_it01",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE40_it01","RAW_FILE_NAME":"QC_HP_itMS2neg_CE40_it01"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE40_it02",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE40_it02","RAW_FILE_NAME":"QC_HP_itMS2neg_CE40_it02"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE40_it03",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE40_it03","RAW_FILE_NAME":"QC_HP_itMS2neg_CE40_it03"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE40_it04",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE40_it04","RAW_FILE_NAME":"QC_HP_itMS2neg_CE40_it04"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE40_it05",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE40_it05","RAW_FILE_NAME":"QC_HP_itMS2neg_CE40_it05"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE40_it06",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE40_it06","RAW_FILE_NAME":"QC_HP_itMS2neg_CE40_it06"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE40_it07",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE40_it07","RAW_FILE_NAME":"QC_HP_itMS2neg_CE40_it07"}
},
{
"Subject ID":"-",
"Sample ID":"QC_HP_itMS2_CE40_it08",
"Factors":{"Group":"MS2","Time_point":"MS2"},
"Additional sample data":{"RAW_FILE_NAME":"QC_HP_itMS2pos_CE40_it08","RAW_FILE_NAME":"QC_HP_itMS2neg_CE40_it08"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Fasted plasma samples were collected from participants at multiple time points as depicted in Figure 1, taken from the protocol paper Nicol, J.L.;Woodrow, C.;Cunningham, B.J.; Mollee, P.;Weber, N.; Smith, M.D.; Nicol, A.J.; Gordon, L.G.; Hill, M.M.; Skinner, T.L. An Individualized Exercise Intervention for People with Multiple Myeloma—Study Protocol of a Randomized Waitlist-Controlled Trial. Curr. Oncol. 2022, 29, 901–923. https://doi.org/10.3390/curroncol29020077. After overnight fasting, plasma was collected by an experienced phlebotomist from an antecubital vein using a 23-gauge needle into EDTA-coated blood collection tubes and immediately stored on ice. Aliquots were prepared in Eppendorf tubes within 4 hours, and frozen at -80oC until use","SAMPLE_TYPE":"Blood (plasma)"},

"TREATMENT":{"TREATMENT_SUMMARY":"Multiple myeloma patients were randomized to exercise (EX) or waitlist (WT) groups as detailed in the protocol paper: Nicol, J.L.;Woodrow, C.;Cunningham, B.J.; Mollee, P.;Weber, N.; Smith, M.D.; Nicol, A.J.; Gordon, L.G.; Hill, M.M.; Skinner, T.L. An Individualized Exercise Intervention for People with Multiple Myeloma—Study Protocol of a Randomized Waitlist-Controlled Trial. Curr. Oncol. 2022, 29, 901–923. https://doi.org/10.3390/curroncol29020077. The individualized exercise program was for 3 months, and follow-up plasma was collected at 12 months. WT group had usual care for 3 months prior to the same exercise and follow-up regime"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"In total, 126 human plasma samples from 46 patients were prepared. All samples (including QCs and blanks) were randomized in one batch and then evenly split between two 2 mL 96-deepwell plates (Eppendorf #0030 501.306). Human plasma samples were thawed on ice and briefly vortexed before aliquoting 100 µL plasma of each sample to a well. In addition, a global sample pool containing equal volumes (12 µL) of each sample was prepared into a 2 mL Eppendorf tube as quality control (QC) and 12 x 100 µL aliquots were transferred into wells across the 2 plates. Finally, blank negative control extraction samples were prepared by transferring 100 µL of 1X PBS to 6 wells equally across 2 plates. Ten-times the sample volume of ice-cold butanol/methanol (1:1) containing 50 µg/mL antioxidant 2,6-di-tert-butyl-4-methylphenol (BHT) and 0.5 µg/mL ISTD 4-chloro-L-phenylalanine (PCPA) was added to each well using a multi-channel pipette. Plates were covered with organic solvent resistant sealing mats (Eppendorf #0030 127.960) and vortexed for 3 min at 1000 rpm. Samples were then sonicated for 15 min in an ice-cold water bath sonicator, stored overnight at -30oC and centrifuged for 30 min at 4,000 x g (4oC). Samples were aliquoted into 96-well V-bottom plates (Greiner #651201) using a liquid handler platform (AssayMap Bravo, Agilent). From each deepwell plate, 4 x 100 µL and 2 x 200 µL aliquots were prepared, totalling 8 and 4 plates, respectively. Samples were dried down (2.5 hrs) using a Genevac EZ-2 vacuum concentrator and fast-stack swings facilitating drying of 8 plates per batch. Dried sample plates were covered with AlumaSeal CS sealing film for cold storage (Finneran-Porviar #FC-100) and stored at -80oC until LC/MS analysis"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"HILIC separation of metabolites was carried out on a Poroshell 120 HILIC-Z (100Å, 2.7µm, 2.1x100mm, #675775-924, Agilent) column at 30ºC and the MS was operated in negative ionization mode. Eluent A was 10 mM ammonium acetate and 5 μM medronic acid in ACN/milliQ 90:10 (pH 9) and eluent B was 10 mM ammonium acetate and 5 μM medronic acid in milliQ (pH 9). Gradient applied was: 0 min (10% eluent B) – 3.5 min (25% B) – 5.5 min (50% B) – 7.5 min (50% B) – 7.6 min (10% B) – 14 min (10% B). Flow rate was set to 0.25 mL/min with a flow ramp to 0.5 mL/min during equilibration","CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Agilent 1290 Infinity II","COLUMN_NAME":"Agilent Poroshell 120 HILIC-Z (2.1x100mm, 2.7 um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 6545 QTOF","INSTRUMENT_TYPE":"QTOF","MS_TYPE":"ESI","ION_MODE":"NEGATIVE","MS_COMMENTS":"MS acquisition: Full scan MS data acquisition (m/z 50-1700) was carried out at a scan rate of 2.5 spectra/sec with the following source conditions applied for metabolites analysed on reversed-phase: Gas temperature 250°C, gas flow 13 L/min, sheath gas temperature and flow at 400°C and 12 L/min, respectively, nebulizer 30 psi, fragmentor 135, capillary voltage at +4500 V, nozzle voltage and CE were zero. For metabolite separation on HILIC conditions were adjusted as follows: Gas temperature 200°C, gas flow 10 L/min, nebulizer 40 psi, capillary voltage at -2500 V. MS/MS acquisition: For compound identification, the ‘Iterative MS/MS’ data acquisition mode was employed, i.e. a sample (here: QC pools) was injected multiple times and precursors previously selected for MS/MS fragmentation were excluded in subsequent runs. Eight iterative MS/MS acquisition runs per fixed collision energy (CE) value were performed with CE values set to 0, 10, 20, and 40 V. Spectral parameters were as follows: MS and MS/MS mass range was 50-1700; MS and MS/MS acquisition rate was 3 spectra/sec; quadrupole isolation width was narrow (~1.3 m/z). A maximum of 8 precursors per cycle were targeted which resulted in a cycle time of 3.1 s. Precursor threshold was set to 500 counts or 0.001% with an active exclusion of 0.2 min after 1 spectra. Iterative MS/MS settings were enabled with a mass error tolerance of +/- 5 ppm and retention time exclusion tolerance of +/- 0.1 min. Precursor charge state was set to 1, 2 and unknown. Precursor abundance-based scan speed with a target of 25,000 counts/spectrum and the use MS/MS accumulation time limit were enabled. Precursor purity stringency was kept at 70% and cutoff 0%. Reference ions were excluded from fragmentation with a delta mass tolerance of 10 ppm. Data processing: Feature extraction was performed separately for each of the 2 LC/MS analysis modes. A total of 148 data files (126 patient samples, 16 QCs, and 6 blank negative control extractions) were loaded into MassHunter Profinder (v 10 SP1, Agilent) and assigned to sample groups. Patient samples were divided into 2 sample groups (waitlist and exercise group), totalling 4 samples groups altogether. First, retention time alignment was conducted using a QC run as reference file. Spectral feature extraction was then performed using the recursive feature extraction method employing default settings with minor adjustments: Peak extraction retention time (Rt) range was restricted to 0.1-5 min and 0.1-7 min for reversed-phase and HILIC, respectively, compound binning and alignment tolerances were set to 1% + 0.3 min for Rt and 20 ppm + 2 mDa for mass, integrator Agile 2 was used for peak integration, peak filters were set to at least 2500 counts and features must have satisfied filter conditions in at least 75 % of files in at least one sample group. Feature peak area was exported and data cleaning was performed in accordance with Southam et al. (2021) using an in-house R script compiled of the following steps. QC samples were removed from the data matrix area if the total peak area (of all features) exceeded +/-25% of the median QC total peak area. Features were deleted from the data matrix if: detected in less than 70% of QC samples; absent across all sample groups; the mean QC/extract blank area ratio was less than 5; and the peak area RSD across QC samples was larger than 30%. In addition, duplicate feature entries were removed.","MS_RESULTS_FILE":"ST002183_AN003576_Results.txt UNITS:peak area Has m/z:Neutral masses Has RT:Yes RT units:Minutes"}

}