{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002803","ANALYSIS_ID":"AN004559","VERSION":"1","CREATED_ON":"July 31, 2023, 10:17 am"},

"PROJECT":{"PROJECT_TITLE":"Metabolic abnormalities in the bone marrow of the newly weaned offspring of obese mothers","PROJECT_SUMMARY":"Obese mothers predispose their babies to develop metabolic disorders and obesity before they are even born. The study used a mouse model of maternal high-fat diet-induced obesity that recapitulates cardiovascular and metabolic abnormalities seen in humans born to obese mothers. to compare the metabolic characteristics of bone marrow cells in newly weaned mice. The results showed that the bone marrow of offspring born to mothers on a high-fat diet primarily used glucose through OXPHOS, and presented decreased amino acid metabolism. These metabolic changes were observed in the bone marrow of the offspring at a very young age, before any symptomatic metabolic disease was present.","INSTITUTE":"Oregon Health and Science University","DEPARTMENT":"Knight Cardiovascular Institute","LABORATORY":"Maloyan laboratory","LAST_NAME":"Maloyan","FIRST_NAME":"Alina","ADDRESS":"3181 S.W. Sam Jackson Park Road, Portland, Oregon, 97239-3098, USA","EMAIL":"maloyan@ohsu.edu","PHONE":"503-494-0012","FUNDING_SOURCE":"NIH HD099367, NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997, www.mmpc.org) under the MICROMouse Program, grants DK076169"},

"STUDY":{"STUDY_TITLE":"Early life metabolic abnormalities in the bone marrow of the offspring of obese mothers","STUDY_SUMMARY":"Obese mothers predispose their babies to develop metabolic disorders and obesity before they are even born. The study used a mouse model of maternal high-fat diet-induced obesity that recapitulates cardiovascular and metabolic abnormalities seen in humans born to obese mothers. to compare the metabolic characteristics of bone marrow cells in newly weaned mice. The results showed that the bone marrow of offspring born to mothers on a high-fat diet primarily used glucose through OXPHOS and presented decreased amino acid metabolism. These metabolic changes were observed in the bone marrow of the offspring at a very young age before any symptomatic metabolic disease was present.","INSTITUTE":"Oregon Health and Science University","DEPARTMENT":"Knight Cardiovascular Institute","LABORATORY":"Maloyan Lab","LAST_NAME":"Maloyan","FIRST_NAME":"Alina","ADDRESS":"3181 S.W. Sam Jackson Park Road, Portland, Oregon, 97239-3098, USA","EMAIL":"maloyan@ohsu.edu","PHONE":"503-494-0012"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENOTYPE_STRAIN":"n/a","AGE_OR_AGE_RANGE":"3 weeks","WEIGHT_OR_WEIGHT_RANGE":"not specified","HEIGHT_OR_HEIGHT_RANGE":"not specified","GENDER":"Male and female","ANIMAL_HOUSING":"regular housing","ANIMAL_FEED":"regular diet","ANIMAL_WATER":"ad libitum"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"B9_001_9",
"Sample ID":"B9_001",
"Factors":{"Treatment Group":"M off-HFD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa02_1.cdf"}
},
{
"Subject ID":"B11_002_11",
"Sample ID":"B11_002",
"Factors":{"Treatment Group":"M off-HFD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa19_1.cdf"}
},
{
"Subject ID":"B17_003_17",
"Sample ID":"B17_003",
"Factors":{"Treatment Group":"M off-HFD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa12_1.cdf"}
},
{
"Subject ID":"B19_004_19",
"Sample ID":"B19_004",
"Factors":{"Treatment Group":"M off-HFD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa04_1.cdf"}
},
{
"Subject ID":"B21_005_21",
"Sample ID":"B21_005",
"Factors":{"Treatment Group":"M off-HFD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa15_1.cdf"}
},
{
"Subject ID":"B4_006_4",
"Sample ID":"B4_006",
"Factors":{"Treatment Group":"F off-HFD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa16_1.cdf"}
},
{
"Subject ID":"B10_007_10",
"Sample ID":"B10_007",
"Factors":{"Treatment Group":"F off-HFD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa03_1.cdf"}
},
{
"Subject ID":"B12_008_12",
"Sample ID":"B12_008",
"Factors":{"Treatment Group":"F off-HFD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa20_1.cdf"}
},
{
"Subject ID":"B18_009_18",
"Sample ID":"B18_009",
"Factors":{"Treatment Group":"F off-HFD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa05_1.cdf"}
},
{
"Subject ID":"B20_010_20",
"Sample ID":"B20_010",
"Factors":{"Treatment Group":"F off-HFD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa17_1.cdf"}
},
{
"Subject ID":"B48_011_48",
"Sample ID":"B48_011",
"Factors":{"Treatment Group":"M off-RD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa08_1.cdf"}
},
{
"Subject ID":"B49_012_49",
"Sample ID":"B49_012",
"Factors":{"Treatment Group":"M off-RD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa06_1.cdf"}
},
{
"Subject ID":"B50_013_50",
"Sample ID":"B50_013",
"Factors":{"Treatment Group":"M off-RD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa18_1.cdf"}
},
{
"Subject ID":"B51_014_51",
"Sample ID":"B51_014",
"Factors":{"Treatment Group":"M off-RD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa10_1.cdf"}
},
{
"Subject ID":"B52_015_52",
"Sample ID":"B52_015",
"Factors":{"Treatment Group":"M off-RD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa07_1.cdf"}
},
{
"Subject ID":"B53_016_53",
"Sample ID":"B53_016",
"Factors":{"Treatment Group":"F off-RD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa01_1.cdf"}
},
{
"Subject ID":"B54_017_54",
"Sample ID":"B54_017",
"Factors":{"Treatment Group":"F off-RD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa09_1.cdf"}
},
{
"Subject ID":"B55_018_55",
"Sample ID":"B55_018",
"Factors":{"Treatment Group":"F off-RD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa13_1.cdf"}
},
{
"Subject ID":"B56_019_56",
"Sample ID":"B56_019",
"Factors":{"Treatment Group":"F off-RD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa14_1.cdf"}
},
{
"Subject ID":"B57_020_57",
"Sample ID":"B57_020",
"Factors":{"Treatment Group":"F off-RD"},
"Additional sample data":{"RAW_FILE_NAME":"201202bDTsa11_1.cdf"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Bone marrow cells were isolated as previously reported (35). Briefly, femurs were flushed by 25G5/8 needle with medium containing RPMI1640+2% FBS+10 units/ml Heparin + penicillin and streptomycin. Bits of bones were removed using a sterile 4um nylon cell strainer (Falcon 352340). Cells were dissolved in 50 ml medium and centrifuged at 2000 rpm (900x g), for 10 minutes at 4oC. Cell pellets were then washed twice with 50 ml of serum-free RPMI (RPMI1640+20mM Hepes + penicillin and streptomycin, adjusted to pH 7.4 before filtering), centrifuged at 2000 rpm, at 4oC for 5 minutes, and resuspended in 25 ml of serum-free RPMI.","SAMPLE_TYPE":"Bone marrow"},

"TREATMENT":{"TREATMENT_SUMMARY":"To induce maternal obesity, high-fat diet (Teklad Cat#TD.06415) or its control, a regular diet (RD, PicoLab® Laboratory Rodent Diet Cat # 5L0D) was given to virgin female FVB/NJ mice from the six-weeks of age and throughout the entire study. After eight weeks of dietary intervention, RD- and HFD-fed female mice were bred to an age-matched RD-fed male. At weaning, male and female offspring from each mother were randomly selected for the study. The offspring were fed a regular diet only starting from weaning and throughout their life."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Full sample was extracted using Matyash extraction procedure which includes MTBE, MeOH, and H2O. The organic (upper) phase was dried down and submitted for resuspension and injection onto the LC while the aqueous (bottom) phase was dried down and submitted to derivatization for GC."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Agilent 7890A","COLUMN_NAME":"Restek Rtx-5Sil (30m x 0.25mm,0.25um)","SOLVENT_A":"-","SOLVENT_B":"-","FLOW_GRADIENT":"-","FLOW_RATE":"1 mL/min","COLUMN_TEMPERATURE":"275"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Leco GC-TOF","INSTRUMENT_TYPE":"GC-TOF","MS_TYPE":"EI","ION_MODE":"POSITIVE","MS_COMMENTS":"Scan range of m/z 120-1200 Da with an acquisition speed of 2 spectra/s."},

"MS_METABOLITE_DATA":{
"Units":"quant m/z",

"Data":[{"Metabolite":"xylose","B10_007":"387","B12_008":"304","B18_009":"311","B20_010":"430","B4_006":"177","B11_002":"440","B17_003":"432","B19_004":"475","B21_005":"687","B9_001":"471","B53_016":"284","B54_017":"285","B55_018":"168","B56_019":"142","B57_020":"276","B48_011":"282","B49_012":"250","B50_013":"233","B51_014":"297","B52_015":"166"},{"Metabolite":"xylitol","B10_007":"2774","B12_008":"2054","B18_009":"2394","B20_010":"2112","B4_006":"2181","B11_002":"2202","B17_003":"2135","B19_004":"3703","B21_005":"3216","B9_001":"2567","B53_016":"2947","B54_017":"2490","B55_018":"2752","B56_019":"2678","B57_020":"2251","B48_011":"2511","B49_012":"2454","B50_013":"2520","B51_014":"2536","B52_015":"2451"},{"Metabolite":"xanthine","B10_007":"2292","B12_008":"2729","B18_009":"2732","B20_010":"3889","B4_006":"887","B11_002":"2883","B17_003":"4086","B19_004":"6942","B21_005":"5801","B9_001":"2395","B53_016":"2246","B54_017":"1963","B55_018":"2190","B56_019":"2792","B57_020":"1947","B48_011":"2304","B49_012":"2068","B50_013":"2106","B51_014":"2094","B52_015":"1655"},{"Metabolite":"valine","B10_007":"59188","B12_008":"74852","B18_009":"61622","B20_010":"64089","B4_006":"45118","B11_002":"111036","B17_003":"78556","B19_004":"89890","B21_005":"68689","B9_001":"97691","B53_016":"193403","B54_017":"327377","B55_018":"182012","B56_019":"283692","B57_020":"324491","B48_011":"292783","B49_012":"307662","B50_013":"193037","B51_014":"285649","B52_015":"301878"},{"Metabolite":"uridine","B10_007":"899","B12_008":"771","B18_009":"557","B20_010":"849","B4_006":"462","B11_002":"1634","B17_003":"1045","B19_004":"1159","B21_005":"1482","B9_001":"511","B53_016":"72","B54_017":"66","B55_018":"76","B56_019":"98","B57_020":"28","B48_011":"46","B49_012":"64","B50_013":"57","B51_014":"66","B52_015":"80"},{"Metabolite":"uric 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id":"171285","PubChem":"64960","KEGG":"C07326"}]
}

}