{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002895","ANALYSIS_ID":"AN004754","VERSION":"1","CREATED_ON":"October 1, 2023, 6:55 pm"},

"PROJECT":{"PROJECT_TITLE":"Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis","PROJECT_SUMMARY":"Folate, an essential vitamin, is a one-carbon acceptor and donor in key metabolic reactions. Erythroid cells harbor a unique sensitivity to folate deprivation, as revealed by the primary pathological manifestation of nutritional folate deprivation: megaloblastic anemia. To study this metabolic sensitivity, we applied mild folate depletion to human and mouse erythroid cell lines, and primary murine erythroid progenitors. We show that folate depletion induces early blockade of purine synthesis and accumulation of the purine synthesis intermediate and signaling molecule, AICAR, followed by enhanced heme metabolism, hemoglobin synthesis, and erythroid differentiation. This is phenocopied by inhibition of folate metabolism using the SHMT1/2 inhibitor - SHIN1, and by AICAR supplementation. Mechanistically, the metabolically-driven differentiation is independent of nucleotide sensing through mTORC1 and AMPK, and is instead mediated by protein kinase C (PKC). Our findings suggest that folate deprivation-induced premature differentiation of erythroid progenitor cells is a molecular etiology to folate-deficiency induced anemia.","INSTITUTE":"Boston Children''s Hospital, Harvard Medical School","DEPARTMENT":"pathology","LABORATORY":"Kanarek Lab","LAST_NAME":"Kanarek","FIRST_NAME":"Naama","ADDRESS":"Enders 1116.2, 300 Longwood Ave, Boston, MA 02115","EMAIL":"naama.kanarek@childrens.harvard.edu","PHONE":"(617) 355-7433"},

"STUDY":{"STUDY_TITLE":"Polar metabolite levels in K562 cells following folate depletion and inosine supplementation","STUDY_SUMMARY":"Culture of K562 cells in RPMI media containing 100 nM folic acid for 48hr in the presence or absence of 100 uM inosine followed my metabolomics targeting polar metabolites.","INSTITUTE":"Boston Children''s Hospital, Harvard Medical School","DEPARTMENT":"pathology","LABORATORY":"Kanarek Lab","LAST_NAME":"Kanarek","FIRST_NAME":"Naama","ADDRESS":"Enders 1116.2, 300 Longwood Ave, Boston, MA 02115","EMAIL":"naama.kanarek@childrens.harvard.edu","PHONE":"6173557433","NUM_GROUPS":"4"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","CELL_STRAIN_DETAILS":"K-562"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"K562",
"Sample ID":"K562_2000nM_FA_Vehicle_HILIC_1",
"Factors":{"Treatment":"2000nM_FA_Vehicle"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM793.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_2000nM_FA_Vehicle_HILIC_2",
"Factors":{"Treatment":"2000nM_FA_Vehicle"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM794.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_2000nM_FA_Vehicle_HILIC_3",
"Factors":{"Treatment":"2000nM_FA_Vehicle"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM795.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_100nM_FA_Vehicle_HILIC_1",
"Factors":{"Treatment":"100nM_FA_Vehicle"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM796.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_100nM_FA_Vehicle_HILIC_2",
"Factors":{"Treatment":"100nM_FA_Vehicle"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM797.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_100nM_FA_Vehicle_HILIC_3",
"Factors":{"Treatment":"100nM_FA_Vehicle"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM798.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_2000nM_FA_Inosine_HILIC_1",
"Factors":{"Treatment":"2000nM_FA_Inosine"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM799.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_2000nM_FA_Inosine_HILIC_2",
"Factors":{"Treatment":"2000nM_FA_Inosine"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM800.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_2000nM_FA_Inosine_HILIC_3",
"Factors":{"Treatment":"2000nM_FA_Inosine"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM801.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_100nM_FA_Inosine_HILIC_1",
"Factors":{"Treatment":"100nM_FA_Inosine"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM802.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_100nM_FA_Inosine_HILIC_2",
"Factors":{"Treatment":"100nM_FA_Inosine"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM803.raw"}
},
{
"Subject ID":"K562",
"Sample ID":"K562_100nM_FA_Inosine_HILIC_3",
"Factors":{"Treatment":"100nM_FA_Inosine"},
"Additional sample data":{"RAW_FILE_NAME":"Copy of 20220701_AM_KM_Inosine_Rescue_D2_AM804.raw"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"One million cells from culture were collected via centrifugation for 20 seconds at 18,000xG, washed with 0.9% NaCl, and collected via centrifugation for 20 seconds at 18,000xG","SAMPLE_TYPE":"Cultured cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"K562 cells were cultured for up to 8 days in 100 nM folic acid containing RPMI media. The treatments were setup as a reverse time-course experiment and harvested on the same day. Day 0 samples were cultured for 8 days in 2,000 nM folic acid."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Pellet was resuspended in extraction buffer (80% Methanol, 25 mM Ammonium Acetate and 2.5 mM Na-Ascorbate prepared in LC-MS water, supplemented with isotopically-labelled amino acid standards [Cambridge Isotope Laboratories, MSK-A2-1.2], aminopterin, and reduced glutathione standard [Cambridge Isotope Laboratories, CNLM-6245-10]). Samples were vortexed for 10 sec, then centrifuged for 10 minutes at 18,000 g to pellet cell debris. The supernatant was divided into two tubes and dried on ice using a liquid nitrogen dryer. One tube of dried sample was used for polar metabolite detection. Dried samples were resuspended in 25 μL water"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Sample was injected into a ZIC-pHILIC 150 x 2.1 mm (5 μm particle size) column (EMD Millipore). operated on a Vanquish™ Flex UHPLC Systems (Thermo Fisher Scientific, San Jose, CA, USA). Chromatographic separation was achieved using the following conditions: buffer A was acetonitrile; buffer B was 20 mM ammonium carbonate, 0.1% ammonium hydroxide in water; resulting pH is around 9 without pH adjustment. Gradient conditions we used were: linear gradient from 20% to 80% B; 20–20.5 min: from 80% to 20% B; 20.5–28 min: hold at 20% B at 150 mL/min flow rate. The column oven and autosampler tray were held at 25 °C and 4 °C, respectively.","CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Thermo Vanquish","COLUMN_NAME":"EMD Millipore ZIC-HILIC (100 x 2.1 mm,3.5 um)","SOLVENT_A":"100% acetonitrile","SOLVENT_B":"100% water; 20 mM ammonium carbonate; 0.1% ammonium hydroxide","FLOW_GRADIENT":"linear gradient from 20% to 80% B; 20–20.5 min: from 80% to 20% B; 20.5–28 min: hold at 20% B at 150 mL/min flow rate","FLOW_RATE":"150 mL/min","COLUMN_TEMPERATURE":"25"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"UNSPECIFIED","MS_COMMENTS":"Polar metabolites were relatively quantified while referencing an in-house library of chemical standards and using TraceFinder 4.1 (Thermo Fisher Scientific, Waltham, MA, USA), with a 5 ppm mass tolerance."},

"MS_METABOLITE_DATA":{
"Units":"peak area",

"Data":[{"Metabolite":"2-hydroxybutyric acid","K562_2000nM_FA_Vehicle_HILIC_1":"3208167.405","K562_2000nM_FA_Vehicle_HILIC_2":"3417997.593","K562_2000nM_FA_Vehicle_HILIC_3":"3453362.316","K562_100nM_FA_Vehicle_HILIC_1":"2777836.575","K562_100nM_FA_Vehicle_HILIC_2":"2505461.421","K562_100nM_FA_Vehicle_HILIC_3":"2379756.969","K562_2000nM_FA_Inosine_HILIC_1":"3317568.136","K562_2000nM_FA_Inosine_HILIC_2":"3585722.828","K562_2000nM_FA_Inosine_HILIC_3":"3540124.131","K562_100nM_FA_Inosine_HILIC_1":"4045274.332","K562_100nM_FA_Inosine_HILIC_2":"3166420.151","K562_100nM_FA_Inosine_HILIC_3":"3358720.986"},{"Metabolite":"2-hydroxyglutarate","K562_2000nM_FA_Vehicle_HILIC_1":"1176531769","K562_2000nM_FA_Vehicle_HILIC_2":"1059873834","K562_2000nM_FA_Vehicle_HILIC_3":"1099901554","K562_100nM_FA_Vehicle_HILIC_1":"1177419977","K562_100nM_FA_Vehicle_HILIC_2":"1093722514","K562_100nM_FA_Vehicle_HILIC_3":"1234811936","K562_2000nM_FA_Inosine_HILIC_1":"1063046060","K562_2000nM_FA_Inosine_HILIC_2":"1132674327","K562_2000nM_FA_Inosine_HILIC_3":"1082752409","K562_100nM_FA_Inosine_HILIC_1":"1122436502","K562_100nM_FA_Inosine_HILIC_2":"1268625699","K562_100nM_FA_Inosine_HILIC_3":"1046134687"},{"Metabolite":"2-oxobutyric acid","K562_2000nM_FA_Vehicle_HILIC_1":"39854009.95","K562_2000nM_FA_Vehicle_HILIC_2":"49000744.98","K562_2000nM_FA_Vehicle_HILIC_3":"45546164.77","K562_100nM_FA_Vehicle_HILIC_1":"44140219.38","K562_100nM_FA_Vehicle_HILIC_2":"44477736.16","K562_100nM_FA_Vehicle_HILIC_3":"50141083.49","K562_2000nM_FA_Inosine_HILIC_1":"46836787","K562_2000nM_FA_Inosine_HILIC_2":"44342353.57","K562_2000nM_FA_Inosine_HILIC_3":"40182513","K562_100nM_FA_Inosine_HILIC_1":"43155047.34","K562_100nM_FA_Inosine_HILIC_2":"51804401.77","K562_100nM_FA_Inosine_HILIC_3":"47424067.55"},{"Metabolite":"2,3-BPG","K562_2000nM_FA_Vehicle_HILIC_1":"24510761.41","K562_2000nM_FA_Vehicle_HILIC_2":"25762527.4","K562_2000nM_FA_Vehicle_HILIC_3":"25561335.47","K562_100nM_FA_Vehicle_HILIC_1":"17980351.38","K562_100nM_FA_Vehicle_HILIC_2":"18528060.57","K562_100nM_FA_Vehicle_HILIC_3":"18921455.39","K562_2000nM_FA_Inosine_HILIC_1":"28373622.16","K562_2000nM_FA_Inosine_HILIC_2":"24826798.41","K562_2000nM_FA_Inosine_HILIC_3":"26713251.81","K562_100nM_FA_Inosine_HILIC_1":"27916530.36","K562_100nM_FA_Inosine_HILIC_2":"28464914.91","K562_100nM_FA_Inosine_HILIC_3":"27817838.95"},{"Metabolite":"3-methyl-2-oxopentanoic acid","K562_2000nM_FA_Vehicle_HILIC_1":"126642172","K562_2000nM_FA_Vehicle_HILIC_2":"140602104.4","K562_2000nM_FA_Vehicle_HILIC_3":"139750270.9","K562_100nM_FA_Vehicle_HILIC_1":"83703620.3","K562_100nM_FA_Vehicle_HILIC_2":"93463734.09","K562_100nM_FA_Vehicle_HILIC_3":"72285921.2","K562_2000nM_FA_Inosine_HILIC_1":"124670063.3","K562_2000nM_FA_Inosine_HILIC_2":"115783220.7","K562_2000nM_FA_Inosine_HILIC_3":"124090140.2","K562_100nM_FA_Inosine_HILIC_1":"140938726.6","K562_100nM_FA_Inosine_HILIC_2":"122829937.8","K562_100nM_FA_Inosine_HILIC_3":"112851817.2"},{"Metabolite":"3-phosphoglycerate","K562_2000nM_FA_Vehicle_HILIC_1":"40481799.69","K562_2000nM_FA_Vehicle_HILIC_2":"40922123.76","K562_2000nM_FA_Vehicle_HILIC_3":"44457486.84","K562_100nM_FA_Vehicle_HILIC_1":"31638065.76","K562_100nM_FA_Vehicle_HILIC_2":"30913425.25","K562_100nM_FA_Vehicle_HILIC_3":"33633731.05","K562_2000nM_FA_Inosine_HILIC_1":"38951476.73","K562_2000nM_FA_Inosine_HILIC_2":"36897580.79","K562_2000nM_FA_Inosine_HILIC_3":"36295152.87","K562_100nM_FA_Inosine_HILIC_1":"37322686.6","K562_100nM_FA_Inosine_HILIC_2":"39430468.58","K562_100nM_FA_Inosine_HILIC_3":"37894397.36"},{"Metabolite":"6-phosphogluconate","K562_2000nM_FA_Vehicle_HILIC_1":"19329161.03","K562_2000nM_FA_Vehicle_HILIC_2":"20187754.07","K562_2000nM_FA_Vehicle_HILIC_3":"18568356.03","K562_100nM_FA_Vehicle_HILIC_1":"12998572.22","K562_100nM_FA_Vehicle_HILIC_2":"12612414.25","K562_100nM_FA_Vehicle_HILIC_3":"11682489.89","K562_2000nM_FA_Inosine_HILIC_1":"16326955.92","K562_2000nM_FA_Inosine_HILIC_2":"16719463.58","K562_2000nM_FA_Inosine_HILIC_3":"15253371.89","K562_100nM_FA_Inosine_HILIC_1":"16380131.77","K562_100nM_FA_Inosine_HILIC_2":"16441543.67","K562_100nM_FA_Inosine_HILIC_3":"14902515.71"},{"Metabolite":"Acetyl-CoA","K562_2000nM_FA_Vehicle_HILIC_1":"17814070.84","K562_2000nM_FA_Vehicle_HILIC_2":"17860707.65","K562_2000nM_FA_Vehicle_HILIC_3":"17388804.28","K562_100nM_FA_Vehicle_HILIC_1":"15032009.01","K562_100nM_FA_Vehicle_HILIC_2":"15401203.71","K562_100nM_FA_Vehicle_HILIC_3":"14579797.39","K562_2000nM_FA_Inosine_HILIC_1":"18603967.62","K562_2000nM_FA_Inosine_HILIC_2":"19007748.26","K562_2000nM_FA_Inosine_HILIC_3":"18036751.39","K562_100nM_FA_Inosine_HILIC_1":"17702182.66","K562_100nM_FA_Inosine_HILIC_2":"18145384.02","K562_100nM_FA_Inosine_HILIC_3":"19138892.66"},{"Metabolite":"acetylcarnitine","K562_2000nM_FA_Vehicle_HILIC_1":"179566368","K562_2000nM_FA_Vehicle_HILIC_2":"166981770.2","K562_2000nM_FA_Vehicle_HILIC_3":"183951727.9","K562_100nM_FA_Vehicle_HILIC_1":"238885487","K562_100nM_FA_Vehicle_HILIC_2":"213117761.6","K562_100nM_FA_Vehicle_HILIC_3":"232235743.5","K562_2000nM_FA_Inosine_HILIC_1":"208578914","K562_2000nM_FA_Inosine_HILIC_2":"194051179.7","K562_2000nM_FA_Inosine_HILIC_3":"205483539.2","K562_100nM_FA_Inosine_HILIC_1":"231379580.5","K562_100nM_FA_Inosine_HILIC_2":"204919633.5","K562_100nM_FA_Inosine_HILIC_3":"210077873.7"},{"Metabolite":"ADP","K562_2000nM_FA_Vehicle_HILIC_1":"24873233.14","K562_2000nM_FA_Vehicle_HILIC_2":"32794991.8","K562_2000nM_FA_Vehicle_HILIC_3":"26453942.47","K562_100nM_FA_Vehicle_HILIC_1":"21361902.23","K562_100nM_FA_Vehicle_HILIC_2":"25850644.93","K562_100nM_FA_Vehicle_HILIC_3":"18087774.45","K562_2000nM_FA_Inosine_HILIC_1":"53053924.24","K562_2000nM_FA_Inosine_HILIC_2":"55388160.6","K562_2000nM_FA_Inosine_HILIC_3":"54462214.64","K562_100nM_FA_Inosine_HILIC_1":"37110423.35","K562_100nM_FA_Inosine_HILIC_2":"38665106.35","K562_100nM_FA_Inosine_HILIC_3":"51107398.82"},{"Metabolite":"alanine","K562_2000nM_FA_Vehicle_HILIC_1":"33492901.81","K562_2000nM_FA_Vehicle_HILIC_2":"32547271.51","K562_2000nM_FA_Vehicle_HILIC_3":"38335042.63","K562_100nM_FA_Vehicle_HILIC_1":"39005866.42","K562_100nM_FA_Vehicle_HILIC_2":"45510999.23","K562_100nM_FA_Vehicle_HILIC_3":"46132689.61","K562_2000nM_FA_Inosine_HILIC_1":"26519863.91","K562_2000nM_FA_Inosine_HILIC_2":"33949776.88","K562_2000nM_FA_Inosine_HILIC_3":"33717157.38","K562_100nM_FA_Inosine_HILIC_1":"29199770.87","K562_100nM_FA_Inosine_HILIC_2":"31470702.44","K562_100nM_FA_Inosine_HILIC_3":"30866979.16"},{"Metabolite":"Alpha-Ketoglutarate","K562_2000nM_FA_Vehicle_HILIC_1":"37154471.37","K562_2000nM_FA_Vehicle_HILIC_2":"41600390.07","K562_2000nM_FA_Vehicle_HILIC_3":"39328567.08","K562_100nM_FA_Vehicle_HILIC_1":"31681656.63","K562_100nM_FA_Vehicle_HILIC_2":"26279448.63","K562_100nM_FA_Vehicle_HILIC_3":"31836929.86","K562_2000nM_FA_Inosine_HILIC_1":"30974833.85","K562_2000nM_FA_Inosine_HILIC_2":"34048040.78","K562_2000nM_FA_Inosine_HILIC_3":"30106853.16","K562_100nM_FA_Inosine_HILIC_1":"34857028.65","K562_100nM_FA_Inosine_HILIC_2":"38714052.08","K562_100nM_FA_Inosine_HILIC_3":"37036681.07"},{"Metabolite":"Alpha-Lipoic 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A_Inosine_HILIC_2":"20750509","K562_2000nM_FA_Inosine_HILIC_3":"21399021.65","K562_100nM_FA_Inosine_HILIC_1":"22179755.99","K562_100nM_FA_Inosine_HILIC_2":"20284773.94","K562_100nM_FA_Inosine_HILIC_3":"19661760.29"},{"Metabolite":"C5-Carnitines","K562_2000nM_FA_Vehicle_HILIC_1":"149639915.6","K562_2000nM_FA_Vehicle_HILIC_2":"139836819.8","K562_2000nM_FA_Vehicle_HILIC_3":"151611609.5","K562_100nM_FA_Vehicle_HILIC_1":"169669274.9","K562_100nM_FA_Vehicle_HILIC_2":"146623561.4","K562_100nM_FA_Vehicle_HILIC_3":"171245154.5","K562_2000nM_FA_Inosine_HILIC_1":"118775440.4","K562_2000nM_FA_Inosine_HILIC_2":"114429904.8","K562_2000nM_FA_Inosine_HILIC_3":"124940493.1","K562_100nM_FA_Inosine_HILIC_1":"130590406.8","K562_100nM_FA_Inosine_HILIC_2":"124477569","K562_100nM_FA_Inosine_HILIC_3":"126005227.5"},{"Metabolite":"carnitine","K562_2000nM_FA_Vehicle_HILIC_1":"196954595.9","K562_2000nM_FA_Vehicle_HILIC_2":"176081655.1","K562_2000nM_FA_Vehicle_HILIC_3":"196194990.1","K562_100nM_FA_Vehicle_HILIC_1":"164684537.7","K562_100nM_FA_Vehicle_HILIC_2":"163058923.2","K562_100nM_FA_Vehicle_HILIC_3":"169712342.9","K562_2000nM_FA_Inosine_HILIC_1":"166962488.3","K562_2000nM_FA_Inosine_HILIC_2":"171842114.9","K562_2000nM_FA_Inosine_HILIC_3":"173807909.1","K562_100nM_FA_Inosine_HILIC_1":"172461379.4","K562_100nM_FA_Inosine_HILIC_2":"161585695.1","K562_100nM_FA_Inosine_HILIC_3":"162990685.2"},{"Metabolite":"CDP-choline","K562_2000nM_FA_Vehicle_HILIC_1":"964662.3112","K562_2000nM_FA_Vehicle_HILIC_2":"650279.0066","K562_2000nM_FA_Vehicle_HILIC_3":"866781.9569","K562_100nM_FA_Vehicle_HILIC_1":"582546.833","K562_100nM_FA_Vehicle_HILIC_2":"788684.5103","K562_100nM_FA_Vehicle_HILIC_3":"670797.5022","K562_2000nM_FA_Inosine_HILIC_1":"900941.5314","K562_2000nM_FA_Inosine_HILIC_2":"711616.9966","K562_2000nM_FA_Inosine_HILIC_3":"651109.259","K562_100nM_FA_Inosine_HILIC_1":"797874.6299","K562_100nM_FA_Inosine_HILIC_2":"843872.3426","K562_100nM_FA_Inosine_HILIC_3":"820765.2981"},{"Metabolite":"cis-aconitate","K562_2000nM_FA_Vehicle_HILIC_1":"26440510.86","K562_2000nM_FA_Vehicle_HILIC_2":"24618821.4","K562_2000nM_FA_Vehicle_HILIC_3":"26186648.82","K562_100nM_FA_Vehicle_HILIC_1":"28424504.68","K562_100nM_FA_Vehicle_HILIC_2":"27390270.41","K562_100nM_FA_Vehicle_HILIC_3":"27098014.02","K562_2000nM_FA_Inosine_HILIC_1":"24031999.7","K562_2000nM_FA_Inosine_HILIC_2":"27397948.27","K562_2000nM_FA_Inosine_HILIC_3":"26147933.64","K562_100nM_FA_Inosine_HILIC_1":"25445734.62","K562_100nM_FA_Inosine_HILIC_2":"24909780.31","K562_100nM_FA_Inosine_HILIC_3":"26284315.84"},{"Metabolite":"citrate","K562_2000nM_FA_Vehicle_HILIC_1":"764307094.3","K562_2000nM_FA_Vehicle_HILIC_2":"764615030.5","K562_2000nM_FA_Vehicle_HILIC_3":"767780478.9","K562_100nM_FA_Vehicle_HILIC_1":"910300235.7","K562_100nM_FA_Vehicle_HILIC_2":"811823753.1","K562_100nM_FA_Vehicle_HILIC_3":"837739638.8","K562_2000nM_FA_Inosine_HILIC_1":"727766138.3","K562_2000nM_FA_Inosine_HILIC_2":"800987628.2","K562_2000nM_FA_Inosine_HILIC_3":"777085794.9","K562_100nM_FA_Inosine_HILIC_1":"760826455.2","K562_100nM_FA_Inosine_HILIC_2":"748854503.1","K562_100nM_FA_Inosine_HILIC_3":"748684152.6"},{"Metabolite":"Coenzyme-A","K562_2000nM_FA_Vehicle_HILIC_1":"5529453.066","K562_2000nM_FA_Vehicle_HILIC_2":"6100720.704","K562_2000nM_FA_Vehicle_HILIC_3":"8293395.945","K562_100nM_FA_Vehicle_HILIC_1":"6481675.366","K562_100nM_FA_Vehicle_HILIC_2":"7021450.895","K562_100nM_FA_Vehicle_HILIC_3":"7174045.867","K562_2000nM_FA_Inosine_HILIC_1":"4925484.318","K562_2000nM_FA_Inosine_HILIC_2":"8549628.61","K562_2000nM_FA_Inosine_HILIC_3":"8417812.409","K562_100nM_FA_Inosine_HILIC_1":"7432296.559","K562_100nM_FA_Inosine_HILIC_2":"8260704.623","K562_100nM_FA_Inosine_HILIC_3":"7507671.555"},{"Metabolite":"creatine","K562_2000nM_FA_Vehicle_HILIC_1":"1071779849","K562_2000nM_FA_Vehicle_HILIC_2":"1163464420","K562_2000nM_FA_Vehicle_HILIC_3":"1230012950","K562_100nM_FA_Vehicle_HILIC_1":"1396363666","K562_100nM_FA_Vehicle_HILIC_2":"1383195589","K562_100nM_FA_Vehicle_HILIC_3":"1462709711","K562_2000nM_FA_Inosine_HILIC_1":"948809246.2","K562_2000nM_FA_Inosine_HILIC_2":"1251234400","K562_2000nM_FA_Inosine_HILIC_3":"1123862291","K562_100nM_FA_Inosine_HILIC_1":"929287845","K562_100nM_FA_Inosine_HILIC_2":"1060333731","K562_100nM_FA_Inosine_HILIC_3":"1021058336"},{"Metabolite":"CTP","K562_2000nM_FA_Vehicle_HILIC_1":"31355671.93","K562_2000nM_FA_Vehicle_HILIC_2":"39658126.53","K562_2000nM_FA_Vehicle_HILIC_3":"30280996.72","K562_100nM_FA_Vehicle_HILIC_1":"35436149.76","K562_100nM_FA_Vehicle_HILIC_2":"43947182.09","K562_100nM_FA_Vehicle_HILIC_3":"30413588.03","K562_2000nM_FA_Inosine_HILIC_1":"28732552.78","K562_2000nM_FA_Inosine_HILIC_2":"25720471.78","K562_2000nM_FA_Inosine_HILIC_3":"25330864.52","K562_100nM_FA_Inosine_HILIC_1":"18433918.14","K562_100nM_FA_Inosine_HILIC_2":"20425940.58","K562_100nM_FA_Inosine_HILIC_3":"28697366.69"},{"Metabolite":"dATP","K562_2000nM_FA_Vehicle_HILIC_1":"3245744.745","K562_2000nM_FA_Vehicle_HILIC_2":"3429464.827","K562_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acid","K562_2000nM_FA_Vehicle_HILIC_1":"3468230.923","K562_2000nM_FA_Vehicle_HILIC_2":"3347421.961","K562_2000nM_FA_Vehicle_HILIC_3":"3890598.444","K562_100nM_FA_Vehicle_HILIC_1":"1272605.991","K562_100nM_FA_Vehicle_HILIC_2":"1435801.524","K562_100nM_FA_Vehicle_HILIC_3":"1365094.738","K562_2000nM_FA_Inosine_HILIC_1":"20189596.22","K562_2000nM_FA_Inosine_HILIC_2":"20615039.98","K562_2000nM_FA_Inosine_HILIC_3":"20460017.94","K562_100nM_FA_Inosine_HILIC_1":"24812720.13","K562_100nM_FA_Inosine_HILIC_2":"24850143.06","K562_100nM_FA_Inosine_HILIC_3":"23927937.34"},{"Metabolite":"UTP","K562_2000nM_FA_Vehicle_HILIC_1":"246232218.5","K562_2000nM_FA_Vehicle_HILIC_2":"286032110.2","K562_2000nM_FA_Vehicle_HILIC_3":"231583129","K562_100nM_FA_Vehicle_HILIC_1":"302816510.8","K562_100nM_FA_Vehicle_HILIC_2":"375537780.1","K562_100nM_FA_Vehicle_HILIC_3":"259455600.5","K562_2000nM_FA_Inosine_HILIC_1":"166325939.5","K562_2000nM_FA_Inosine_HILIC_2":"149220234.7","K562_2000nM_FA_Inosine_HILIC_3":"143469271","K562_100nM_FA_Inosine_HILIC_1":"109689611.3","K562_100nM_FA_Inosine_HILIC_2":"126829965.3","K562_100nM_FA_Inosine_HILIC_3":"164436201.9"},{"Metabolite":"xanthine","K562_2000nM_FA_Vehicle_HILIC_1":"","K562_2000nM_FA_Vehicle_HILIC_2":"","K562_2000nM_FA_Vehicle_HILIC_3":"","K562_100nM_FA_Vehicle_HILIC_1":"","K562_100nM_FA_Vehicle_HILIC_2":"","K562_100nM_FA_Vehicle_HILIC_3":"","K562_2000nM_FA_Inosine_HILIC_1":"376686.0507","K562_2000nM_FA_Inosine_HILIC_2":"359220.7733","K562_2000nM_FA_Inosine_HILIC_3":"542307.4777","K562_100nM_FA_Inosine_HILIC_1":"483484.0163","K562_100nM_FA_Inosine_HILIC_2":"413183.0466","K562_100nM_FA_Inosine_HILIC_3":"382757.838"},{"Metabolite":"xanthosine","K562_2000nM_FA_Vehicle_HILIC_1":"90595.46524","K562_2000nM_FA_Vehicle_HILIC_2":"61874.52697","K562_2000nM_FA_Vehicle_HILIC_3":"55936.2871","K562_100nM_FA_Vehicle_HILIC_1":"68947.40225","K562_100nM_FA_Vehicle_HILIC_2":"78945.47197","K562_100nM_FA_Vehicle_HILIC_3":"119729.2188","K562_2000nM_FA_Inosine_HILIC_1":"99147.03556","K562_2000nM_FA_Inosine_HILIC_2":"58474.92676","K562_2000nM_FA_Inosine_HILIC_3":"68516.925","K562_100nM_FA_Inosine_HILIC_1":"76422.02326","K562_100nM_FA_Inosine_HILIC_2":"93784.36956","K562_100nM_FA_Inosine_HILIC_3":"109186.5172"}],

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acid","Formula":"C6H13O10P","Exact mass":"276.0246","Sub class":"Monosaccharide phosphates"},{"Metabolite":"Acetyl-CoA","Standardized name":"Acetyl-CoA","Formula":"C23H38N7O17P3S","Exact mass":"809.1258","Sub class":"Acyl CoAs"},{"Metabolite":"acetylcarnitine","Standardized name":"CAR 2:0","Formula":"C9H17NO4","Exact mass":"203.1158","Sub class":"Acyl carnitines"},{"Metabolite":"ADP","Standardized name":"ADP","Formula":"C10H15N5O10P2","Exact mass":"427.0294","Sub class":"Purine rNDP"},{"Metabolite":"alanine","Standardized name":"Alanine","Formula":"C3H7NO2","Exact mass":"89.0477","Sub class":"Amino acids"},{"Metabolite":"Alpha-Ketoglutarate","Standardized name":"Oxoglutaric acid","Formula":"C5H6O5","Exact mass":"146.0215","Sub class":"TCA acids"},{"Metabolite":"Alpha-Lipoic Acid","Standardized name":"Lipoic acid","Formula":"C8H14O2S2","Exact mass":"206.0435","Sub class":"Thia FA"},{"Metabolite":"AMP","Standardized name":"AMP","Formula":"C10H14N5O7P","Exact mass":"347.0631","Sub class":"Purine rNMP"},{"Metabolite":"arginine","Standardized name":"Arginine","Formula":"C6H14N4O2","Exact mass":"174.1117","Sub class":"Amino acids"},{"Metabolite":"argininosuccinate","Standardized name":"Argininosuccinic acid","Formula":"C10H18N4O6","Exact mass":"290.1226","Sub class":"Amino acids"},{"Metabolite":"asparagine","Standardized name":"Asparagine","Formula":"C4H8N2O3","Exact mass":"132.0535","Sub class":"Amino acids"},{"Metabolite":"aspartate","Standardized name":"Aspartic acid","Formula":"C4H7NO4","Exact mass":"133.0375","Sub class":"Amino acids"},{"Metabolite":"ATP","Standardized name":"ATP","Formula":"C10H16N5O13P3","Exact mass":"506.9958","Sub class":"Purine rNTP"},{"Metabolite":"beta-alanine","Standardized name":"beta-Alanine","Formula":"C3H7NO2","Exact mass":"89.0477","Sub class":"Amino acids"},{"Metabolite":"Butyrylcarnitine","Standardized name":"CAR 4:0","Formula":"C11H21NO4","Exact mass":"231.1471","Sub class":"Acyl carnitines"},{"Metabolite":"C5-Carnitines","Standardized name":"-","Formula":"-","Exact mass":"-","Sub class":"-"},{"Metabolite":"carnitine","Standardized name":"Carnitine","Formula":"C7H15NO3","Exact mass":"161.1052","Sub class":"Carnitines"},{"Metabolite":"CDP-choline","Standardized name":"CDP-choline","Formula":"C14H26N4O11P2","Exact mass":"488.1073","Sub class":"Pyrimidine rNDP"},{"Metabolite":"cis-aconitate","Standardized name":"cis-Aconitic acid","Formula":"C6H6O6","Exact mass":"174.0164","Sub class":"TCA acids"},{"Metabolite":"citrate","Standardized name":"Citric acid","Formula":"C6H8O7","Exact mass":"192.0270","Sub class":"TCA acids"},{"Metabolite":"Coenzyme-A","Standardized name":"Coenzyme A","Formula":"C21H36N7O16P3S","Exact mass":"767.1152","Sub class":"Other purines"},{"Metabolite":"creatine","Standardized name":"Creatine","Formula":"C4H9N3O2","Exact mass":"131.0695","Sub class":"Amino acids"},{"Metabolite":"CTP","Standardized name":"CTP","Formula":"C9H16N3O14P3","Exact mass":"482.9845","Sub class":"Pyrimidine rNTP"},{"Metabolite":"dATP","Standardized name":"dATP","Formula":"C10H16N5O12P3","Exact mass":"491.0008","Sub class":"Purine dNTP"},{"Metabolite":"dCTP","Standardized name":"dCTP","Formula":"C9H16N3O13P3","Exact mass":"466.9896","Sub class":"Pyrimidine dNTP"},{"Metabolite":"dihydroxyacetonephosphate","Standardized name":"Dihydroxyacetone phosphate","Formula":"C3H7O6P","Exact mass":"169.9980","Sub class":"Short-chain acids"},{"Metabolite":"erythrose-4-phosphate","Standardized name":"Erythrose 4-phosphate","Formula":"C4H9O7P","Exact mass":"200.0086","Sub class":"Monosaccharide phosphates"},{"Metabolite":"F6P G1P","Standardized name":"-","Formula":"-","Exact mass":"-","Sub class":"-"},{"Metabolite":"folic acid","Standardized name":"Folic acid","Formula":"C19H19N7O6","Exact mass":"441.1397","Sub class":"Folic acids"},{"Metabolite":"formyl methionine","Standardized name":"N-Formylmethionine","Formula":"C6H11NO3S","Exact mass":"177.0460","Sub class":"Amino acids"},{"Metabolite":"Fructose-1,6-bisphosphate","Standardized name":"Fructose 1,6-bisphosphate","Formula":"C6H14O12P2","Exact mass":"339.9961","Sub class":"Monosaccharide phosphates"},{"Metabolite":"fumarate","Standardized name":"Fumaric acid","Formula":"C4H4O4","Exact mass":"116.0110","Sub class":"TCA acids"},{"Metabolite":"GAR","Standardized name":"GAR","Formula":"C7H15N2O8P","Exact mass":"286.0566","Sub class":"Glycinamide ribonucleotides"},{"Metabolite":"GDP","Standardized name":"GDP","Formula":"C10H15N5O11P2","Exact mass":"443.0243","Sub class":"Purine rNDP"},{"Metabolite":"Glucose-6-phosphate","Standardized name":"Glucose 6-phosphate","Formula":"C6H13O9P","Exact mass":"260.0297","Sub class":"Monosaccharide phosphates"},{"Metabolite":"glutamate","Standardized name":"Glutamic acid","Formula":"C5H9NO4","Exact mass":"147.0532","Sub class":"Amino acids"},{"Metabolite":"glutamine","Standardized name":"Glutamine","Formula":"C5H10N2O3","Exact mass":"146.0691","Sub class":"Amino acids"},{"Metabolite":"glycerate","Standardized name":"Glyceric acid","Formula":"C3H6O4","Exact mass":"106.0266","Sub class":"Sugar acids"},{"Metabolite":"Glycerol-3-Phosphate","Standardized name":"sn-Glycero-3-phosphate","Formula":"C3H9O6P","Exact mass":"172.0137","Sub class":"Organic phosphoric acids"},{"Metabolite":"Glycerophosphocholine","Standardized name":"sn-Glycero-3-phosphocholine","Formula":"C8H20NO6P","Exact mass":"257.1028","Sub class":"Organic phosphoric acids"},{"Metabolite":"glycine","Standardized name":"Glycine","Formula":"C2H5NO2","Exact mass":"75.0320","Sub class":"Amino acids"},{"Metabolite":"GSH","Standardized name":"Glutathione","Formula":"C10H17N3O6S","Exact mass":"307.0838","Sub class":"Tripeptides"},{"Metabolite":"hydroxyproline gammaALA","Standardized name":"-","Formula":"-","Exact mass":"-","Sub class":"-"},{"Metabolite":"hypotaurine","Standardized name":"Hypotaurine","Formula":"C2H7NO2S","Exact mass":"109.0198","Sub class":"Sulfinic acids"},{"Metabolite":"hypoxanthine","Standardized name":"Hypoxanthine","Formula":"C5H4N4O","Exact mass":"136.0385","Sub class":"Hypoxanthines"},{"Metabolite":"IMP","Standardized name":"IMP","Formula":"C10H13N4O8P","Exact mass":"348.0471","Sub class":"Purine rNMP"},{"Metabolite":"leucine","Standardized name":"Leucine","Formula":"C6H13NO2","Exact mass":"131.0946","Sub class":"Amino acids"},{"Metabolite":"lysine","Standardized name":"Lysine","Formula":"C6H14N2O2","Exact mass":"146.1055","Sub class":"Amino acids"},{"Metabolite":"malate","Standardized name":"D-Malic acid","Formula":"C4H6O5","Exact mass":"134.0215","Sub class":"Beta hydroxy acids"},{"Metabolite":"malonyl-CoA","Standardized name":"Malonyl-CoA","Formula":"C24H38N7O19P3S","Exact mass":"853.1156","Sub class":"Acyl CoAs"},{"Metabolite":"methionine","Standardized name":"Methionine","Formula":"C5H11NO2S","Exact mass":"149.0511","Sub class":"Amino acids"},{"Metabolite":"methylthioadenosine","Standardized name":"Methylthioadenosine","Formula":"C11H15N5O3S","Exact mass":"297.0896","Sub class":"Purine ribonucleosides"},{"Metabolite":"N-acetylaspartate","Standardized name":"N-Acetylaspartic acid","Formula":"C6H9NO5","Exact mass":"175.0481","Sub class":"Amino acids"},{"Metabolite":"N-acetylmethionine","Standardized name":"N-Acetylmethionine","Formula":"C7H13NO3S","Exact mass":"191.0616","Sub class":"Amino acids"},{"Metabolite":"N-acetylphenylalanine","Standardized name":"N-Acetylphenylalanine","Formula":"C11H13NO3","Exact mass":"207.0895","Sub class":"Amino acids"},{"Metabolite":"NAD.","Standardized name":"NAD+","Formula":"C21H27N7O14P2","Exact mass":"663.1091","Sub class":"Nicotinamide dinucleotides"},{"Metabolite":"NADP","Standardized name":"NADP+","Formula":"C21H28N7O17P3","Exact mass":"743.0755","Sub class":"Nicotinamide dinucleotides"},{"Metabolite":"niacinamide","Standardized name":"Niacinamide","Formula":"C6H6N2O","Exact mass":"122.0480","Sub class":"Pyridine alkaloids"},{"Metabolite":"O-phosphoethanolamine","Standardized name":"Phosphoethanolamine","Formula":"C2H8NO4P","Exact mass":"141.0191","Sub class":"Phosphoethanolamines"},{"Metabolite":"Pantothenate","Standardized name":"Pantothenic acid","Formula":"C9H17NO5","Exact mass":"219.1107","Sub class":"Amino acids"},{"Metabolite":"phenylalanine","Standardized name":"Phenylalanine","Formula":"C9H11NO2","Exact mass":"165.0790","Sub class":"Amino acids"},{"Metabolite":"phosphocholine","Standardized name":"Choline phosphate","Formula":"C5H14NO4P","Exact mass":"183.0660","Sub class":"Cholines"},{"Metabolite":"phosphocreatine","Standardized name":"Phosphocreatine","Formula":"C4H10N3O5P","Exact mass":"211.0358","Sub class":"Amino acids"},{"Metabolite":"phosphoenolpyruvate","Standardized name":"Phosphoenolpyruvic acid","Formula":"C3H5O6P","Exact mass":"167.9824","Sub class":"Short-chain acids"},{"Metabolite":"proline","Standardized name":"Proline","Formula":"C5H9NO2","Exact mass":"115.0633","Sub class":"Amino acids"},{"Metabolite":"propionylcarnitine","Standardized name":"CAR 3:0","Formula":"C10H19NO4","Exact mass":"217.1314","Sub class":"Acyl carnitines"},{"Metabolite":"PRPP","Standardized name":"Phosphoribosyl pyrophosphate","Formula":"C5H13O14P3","Exact mass":"389.9518","Sub class":"Monosaccharide phosphates"},{"Metabolite":"Pyridoxine","Standardized name":"Pyridoxine","Formula":"C8H11NO3","Exact mass":"169.0739","Sub class":"Pyridine alkaloids"},{"Metabolite":"pyruvate","Standardized name":"Pyruvic acid","Formula":"C3H4O3","Exact mass":"88.0160","Sub class":"Short-chain acids"},{"Metabolite":"quinolinic acid","Standardized name":"Quinolinic acid","Formula":"C7H5NO4","Exact mass":"167.0219","Sub class":"Pyridine alkaloids"},{"Metabolite":"Ribose-1-phosphate","Standardized name":"Ribose 1-phosphate","Formula":"C5H11O8P","Exact mass":"230.0192","Sub class":"Monosaccharide phosphates"},{"Metabolite":"Ribose.Ribulose.5.phosphate.3Me.Lys","Standardized name":"-","Formula":"-","Exact mass":"-","Sub class":"-"},{"Metabolite":"S-Adenosyl-L-Homocysteine","Standardized name":"S-Adenosylhomocysteine","Formula":"C14H20N6O5S","Exact mass":"384.1216","Sub class":"Other purines"},{"Metabolite":"Sedoheptulose-7-phosphate","Standardized name":"Sedoheptulose 7-phosphate","Formula":"C7H15O10P","Exact mass":"290.0403","Sub class":"Monosaccharide phosphates"},{"Metabolite":"serine","Standardized name":"Serine","Formula":"C3H7NO3","Exact mass":"105.0426","Sub class":"Amino acids"},{"Metabolite":"succinate","Standardized name":"Succinic acid","Formula":"C4H6O4","Exact mass":"118.0266","Sub class":"TCA acids"},{"Metabolite":"taurine","Standardized name":"Taurine","Formula":"C2H7NO3S","Exact mass":"125.0147","Sub class":"Sulfonic acids"},{"Metabolite":"threonine","Standardized name":"Threonine","Formula":"C4H9NO3","Exact mass":"119.0582","Sub class":"Amino acids"},{"Metabolite":"tryptophan","Standardized name":"Tryptophan","Formula":"C11H12N2O2","Exact mass":"204.0899","Sub class":"Amino acids"},{"Metabolite":"tyrosine","Standardized name":"Tyrosine","Formula":"C9H11NO3","Exact mass":"181.0739","Sub class":"Amino acids"},{"Metabolite":"UDP.GlcNAc","Standardized name":"UDP-N-acetylglucosamine","Formula":"C17H27N3O17P2","Exact mass":"607.0816","Sub class":"Pyrimidine ribonucleosides"},{"Metabolite":"UDP","Standardized name":"UDP","Formula":"C9H14N2O12P2","Exact mass":"404.0022","Sub class":"Pyrimidine rNDP"},{"Metabolite":"UMP","Standardized name":"UMP","Formula":"C9H13N2O9P","Exact mass":"324.0359","Sub class":"Pyrimidine rNMP"},{"Metabolite":"Ureidosuccinic acid","Standardized name":"N-Carbamoylaspartic acid","Formula":"C5H8N2O5","Exact mass":"176.0433","Sub class":"Amino acids"},{"Metabolite":"UTP","Standardized name":"UTP","Formula":"C9H15N2O15P3","Exact mass":"483.9685","Sub class":"Pyrimidine rNTP"},{"Metabolite":"xanthine","Standardized name":"Xanthine","Formula":"C5H4N4O2","Exact mass":"152.0334","Sub class":"Xanthines"},{"Metabolite":"xanthosine","Standardized name":"Xanthosine","Formula":"C10H12N4O6","Exact mass":"284.0757","Sub class":"Purine ribonucleosides"}]
}

}