{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003011","ANALYSIS_ID":"AN004943","VERSION":"1","CREATED_ON":"December 13, 2023, 3:06 am"},

"PROJECT":{"PROJECT_TITLE":"Effects of the human intestinal bacterium Eggerthella lenta in gut of gnotobiotic mice","PROJECT_SUMMARY":"In this work, we used the minimal consortium Oligo-Mouse Microbiota (OMM)12 to study the function of Coriobacteriia under defined conditions in gnotobiotic mice. OMM12 mice with or without addition of the dominant gut bacterium Eggerthella lenta were fed with diets varying in fat content or supplemented with primary bile acids.","INSTITUTE":"Helmholtz Centre for Environmental Research","DEPARTMENT":"Molecular Systems Biology","LAST_NAME":"Engelmann","FIRST_NAME":"Beatrice","ADDRESS":"Permoserstrasse 15, 04318 Leipzig, Germany","EMAIL":"beatrice.engelmann@ufz.de","PHONE":"00493411099"},

"STUDY":{"STUDY_TITLE":"Untargeted metabolomics analysis of murine colon content","STUDY_SUMMARY":"we used the minimal consortium Oligo-Mouse Microbiota (OMM)12 to study the function of Coriobacteriia under defined conditions in gnotobiotic mice. OMM12 mice with or without addition of the dominant gut bacterium Eggerthella lenta were fed with diets varying in fat content or supplemented with primary bile acids.","INSTITUTE":"Helmholtz Centre for Environmental Research","DEPARTMENT":"Molecular Systems Biology","LAST_NAME":"Engelmann","FIRST_NAME":"Beatrice","ADDRESS":"Permoserstrasse 15, 04318 Leipzig, Germany","EMAIL":"beatrice.engelmann@ufz.de","PHONE":"+493411099"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"2_O_HFD",
"Sample ID":"2_O_HFD",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"2_O_HFD.mzML"}
},
{
"Subject ID":"3_O_HFD",
"Sample ID":"3_O_HFD",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"3_O_HFD.mzML"}
},
{
"Subject ID":"4_O_HFD",
"Sample ID":"4_O_HFD",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"4_O_HFD.mzML"}
},
{
"Subject ID":"5_O_HFD",
"Sample ID":"5_O_HFD",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"5_O_HFD.mzML"}
},
{
"Subject ID":"6_O_HFD",
"Sample ID":"6_O_HFD",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"6_O_HFD.mzML"}
},
{
"Subject ID":"7_O_HFD",
"Sample ID":"7_O_HFD",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"7_O_HFD.mzML"}
},
{
"Subject ID":"8_O_BA",
"Sample ID":"8_O_BA",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"8_O_BA.mzML"}
},
{
"Subject ID":"9_O_HFD.BA",
"Sample ID":"9_O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"9_O_HFD.BA.mzML"}
},
{
"Subject ID":"11_O_BA",
"Sample ID":"11_O_BA",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"11_O_BA.mzML"}
},
{
"Subject ID":"13_O_CD",
"Sample ID":"13_O_CD",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"13_O_CD.mzML"}
},
{
"Subject ID":"14_O_CD",
"Sample ID":"14_O_CD",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"14_O_CD.mzML"}
},
{
"Subject ID":"17_Corio.O_CD",
"Sample ID":"17_Corio.O_CD",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"17_Corio.O_CD.mzML"}
},
{
"Subject ID":"19_Corio.O_CD",
"Sample ID":"19_Corio.O_CD",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"19_Corio.O_CD.mzML"}
},
{
"Subject ID":"20_Corio.O_CD",
"Sample ID":"20_Corio.O_CD",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"20_Corio.O_CD.mzML"}
},
{
"Subject ID":"21_Corio.O_BA",
"Sample ID":"21_Corio.O_BA",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"21_Corio.O_BA.mzML"}
},
{
"Subject ID":"22_Corio.O_BA",
"Sample ID":"22_Corio.O_BA",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"22_Corio.O_BA.mzML"}
},
{
"Subject ID":"23_Corio.O_BA",
"Sample ID":"23_Corio.O_BA",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"23_Corio.O_BA.mzML"}
},
{
"Subject ID":"24_Corio.O_BA",
"Sample ID":"24_Corio.O_BA",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"24_Corio.O_BA.mzML"}
},
{
"Subject ID":"25_Corio.O_HFD",
"Sample ID":"25_Corio.O_HFD",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"25_Corio.O_HFD.mzML"}
},
{
"Subject ID":"27_Corio.O_HFD",
"Sample ID":"27_Corio.O_HFD",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"27_Corio.O_HFD.mzML"}
},
{
"Subject ID":"28_Corio.O_HFD",
"Sample ID":"28_Corio.O_HFD",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"28_Corio.O_HFD.mzML"}
},
{
"Subject ID":"29_Corio.O_HFD.BA",
"Sample ID":"29_Corio.O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"29_Corio.O_HFD.BA.mzML"}
},
{
"Subject ID":"30_Corio.O_HFD.BA",
"Sample ID":"30_Corio.O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"30_Corio.O_HFD.BA.mzML"}
},
{
"Subject ID":"31_Corio.O_HFD.BA",
"Sample ID":"31_Corio.O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"31_Corio.O_HFD.BA.mzML"}
},
{
"Subject ID":"32_Corio.O_HFD.BA",
"Sample ID":"32_Corio.O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"32_Corio.O_HFD.BA.mzML"}
},
{
"Subject ID":"33_Corio.O_CD",
"Sample ID":"33_Corio.O_CD",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"33_Corio.O_CD.mzML"}
},
{
"Subject ID":"34_Corio.O_CD",
"Sample ID":"34_Corio.O_CD",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"34_Corio.O_CD.mzML"}
},
{
"Subject ID":"35_Corio.O_CD",
"Sample ID":"35_Corio.O_CD",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"35_Corio.O_CD.mzML"}
},
{
"Subject ID":"36_O_CD",
"Sample ID":"36_O_CD",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"36_O_CD.mzML"}
},
{
"Subject ID":"37_O_CD",
"Sample ID":"37_O_CD",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"37_O_CD.mzML"}
},
{
"Subject ID":"38_O_CD",
"Sample ID":"38_O_CD",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"38_O_CD.mzML"}
},
{
"Subject ID":"39_O_HFD",
"Sample ID":"39_O_HFD",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"39_O_HFD.mzML"}
},
{
"Subject ID":"40_O_HFD",
"Sample ID":"40_O_HFD",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"40_O_HFD.mzML"}
},
{
"Subject ID":"41_O_HFD",
"Sample ID":"41_O_HFD",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"41_O_HFD.mzML"}
},
{
"Subject ID":"42_O_BA",
"Sample ID":"42_O_BA",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"42_O_BA.mzML"}
},
{
"Subject ID":"43_Corio.O_BA",
"Sample ID":"43_Corio.O_BA",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"43_Corio.O_BA.mzML"}
},
{
"Subject ID":"44_Corio.O_BA",
"Sample ID":"44_Corio.O_BA",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"44_Corio.O_BA.mzML"}
},
{
"Subject ID":"45_Corio.O_BA",
"Sample ID":"45_Corio.O_BA",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"45_Corio.O_BA.mzML"}
},
{
"Subject ID":"46_O_CD",
"Sample ID":"46_O_CD",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"46_O_CD.mzML"}
},
{
"Subject ID":"47_Corio.O_HFD.BA",
"Sample ID":"47_Corio.O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"47_Corio.O_HFD.BA.mzML"}
},
{
"Subject ID":"48_Corio.O_HFD.BA",
"Sample ID":"48_Corio.O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"48_Corio.O_HFD.BA.mzML"}
},
{
"Subject ID":"49_Corio.O_HFD.BA",
"Sample ID":"49_Corio.O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"49_Corio.O_HFD.BA.mzML"}
},
{
"Subject ID":"50_Corio.O_HFD",
"Sample ID":"50_Corio.O_HFD",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"50_Corio.O_HFD.mzML"}
},
{
"Subject ID":"51_Corio.O_HFD",
"Sample ID":"51_Corio.O_HFD",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"51_Corio.O_HFD.mzML"}
},
{
"Subject ID":"52_Corio.O_HFD",
"Sample ID":"52_Corio.O_HFD",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"52_Corio.O_HFD.mzML"}
},
{
"Subject ID":"53_Corio.O_HFD",
"Sample ID":"53_Corio.O_HFD",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"53_Corio.O_HFD.mzML"}
},
{
"Subject ID":"54_O_BA",
"Sample ID":"54_O_BA",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"54_O_BA.mzML"}
},
{
"Subject ID":"55_O_BA",
"Sample ID":"55_O_BA",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"55_O_BA.mzML"}
},
{
"Subject ID":"56_O_BA",
"Sample ID":"56_O_BA",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"56_O_BA.mzML"}
},
{
"Subject ID":"57_O_BA",
"Sample ID":"57_O_BA",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"57_O_BA.mzML"}
},
{
"Subject ID":"58_O_HFD.BA",
"Sample ID":"58_O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"58_O_HFD.BA.mzML"}
},
{
"Subject ID":"59_O_HFD.BA",
"Sample ID":"59_O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"59_O_HFD.BA.mzML"}
},
{
"Subject ID":"60_O_HFD.BA",
"Sample ID":"60_O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"60_O_HFD.BA.mzML"}
},
{
"Subject ID":"61_O_HFD.BA",
"Sample ID":"61_O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"61_O_HFD.BA.mzML"}
},
{
"Subject ID":"422_Corio.O_BA",
"Sample ID":"422_Corio.O_BA",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"422_Corio.O_BA.mzML"}
},
{
"Subject ID":"462_Corio.O_HFD.BA",
"Sample ID":"462_Corio.O_HFD.BA",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"462_Corio.O_HFD.BA.mzML"}
},
{
"Subject ID":"11_6_O_BA",
"Sample ID":"11_6_O_BA",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"11+6_O_BA.mzML"}
},
{
"Subject ID":"2_O_HFD",
"Sample ID":"2_O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"2_O_HFD_pos.mzML"}
},
{
"Subject ID":"3_O_HFD",
"Sample ID":"3_O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"3_O_HFD_pos.mzML"}
},
{
"Subject ID":"4_O_HFD",
"Sample ID":"4_O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"4_O_HFD_pos.mzML"}
},
{
"Subject ID":"5_O_HFD",
"Sample ID":"5_O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"5_O_HFD_pos.mzML"}
},
{
"Subject ID":"6_O_HFD",
"Sample ID":"6_O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"6_O_HFD_pos.mzML"}
},
{
"Subject ID":"7_O_HFD",
"Sample ID":"7_O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"7_O_HFD_pos.mzML"}
},
{
"Subject ID":"8_O_BA",
"Sample ID":"8_O_BA_pos",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"8_O_BA_pos.mzML"}
},
{
"Subject ID":"9_O_HFD.BA",
"Sample ID":"9_O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"9_O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"11_O_BA",
"Sample ID":"11_O_BA_pos",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"11_O_BA_pos.mzML"}
},
{
"Subject ID":"13_O_CD",
"Sample ID":"13_O_CD_pos",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"13_O_CD_pos.mzML"}
},
{
"Subject ID":"14_O_CD",
"Sample ID":"14_O_CD_pos",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"14_O_CD_pos.mzML"}
},
{
"Subject ID":"17_Corio.O_CD",
"Sample ID":"17_Corio.O_CD_pos",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"17_Corio.O_CD_pos.mzML"}
},
{
"Subject ID":"19_Corio.O_CD",
"Sample ID":"19_Corio.O_CD_pos",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"19_Corio.O_CD_pos.mzML"}
},
{
"Subject ID":"20_Corio.O_CD",
"Sample ID":"20_Corio.O_CD_pos",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"20_Corio.O_CD_pos.mzML"}
},
{
"Subject ID":"21_Corio.O_BA",
"Sample ID":"21_Corio.O_BA_pos",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"21_Corio.O_BA_pos.mzML"}
},
{
"Subject ID":"22_Corio.O_BA",
"Sample ID":"22_Corio.O_BA_pos",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"22_Corio.O_BA_pos.mzML"}
},
{
"Subject ID":"23_Corio.O_BA",
"Sample ID":"23_Corio.O_BA_pos",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"23_Corio.O_BA_pos.mzML"}
},
{
"Subject ID":"24_Corio.O_BA",
"Sample ID":"24_Corio.O_BA_pos",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"24_Corio.O_BA_pos.mzML"}
},
{
"Subject ID":"25_Corio.O_HFD",
"Sample ID":"25_Corio.O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"25_Corio.O_HFD_pos.mzML"}
},
{
"Subject ID":"27_Corio.O_HFD",
"Sample ID":"27_Corio.O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"27_Corio.O_HFD_pos.mzML"}
},
{
"Subject ID":"28_Corio.O_HFD",
"Sample ID":"28_Corio.O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"28_Corio.O_HFD_pos.mzML"}
},
{
"Subject ID":"29_Corio.O_HFD.BA",
"Sample ID":"29_Corio.O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"29_Corio.O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"30_Corio.O_HFD.BA",
"Sample ID":"30_Corio.O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"30_Corio.O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"31_Corio.O_HFD.BA",
"Sample ID":"31_Corio.O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"31_Corio.O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"32_Corio.O_HFD.BA",
"Sample ID":"32_Corio.O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"32_Corio.O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"33_Corio.O_CD",
"Sample ID":"33_Corio.O_CD_pos",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"33_Corio.O_CD_pos.mzML"}
},
{
"Subject ID":"34_Corio.O_CD",
"Sample ID":"34_Corio.O_CD_pos",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"34_Corio.O_CD_pos.mzML"}
},
{
"Subject ID":"35_Corio.O_CD",
"Sample ID":"35_Corio.O_CD_pos",
"Factors":{"Diet":"CD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"35_Corio.O_CD_pos.mzML"}
},
{
"Subject ID":"36_O_CD",
"Sample ID":"36_O_CD_pos",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"36_O_CD_pos.mzML"}
},
{
"Subject ID":"37_O_CD",
"Sample ID":"37_O_CD_pos",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"37_O_CD_pos.mzML"}
},
{
"Subject ID":"38_O_CD",
"Sample ID":"38_O_CD_pos",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"38_O_CD_pos.mzML"}
},
{
"Subject ID":"39_O_HFD",
"Sample ID":"39_O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"39_O_HFD_pos.mzML"}
},
{
"Subject ID":"40_O_HFD",
"Sample ID":"40_O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"40_O_HFD_pos.mzML"}
},
{
"Subject ID":"41_O_HFD",
"Sample ID":"41_O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"41_O_HFD_pos.mzML"}
},
{
"Subject ID":"42_O_BA",
"Sample ID":"42_O_BA_pos",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"42_O_BA_pos.mzML"}
},
{
"Subject ID":"43_Corio.O_BA",
"Sample ID":"43_Corio.O_BA_pos",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"43_Corio.O_BA_pos.mzML"}
},
{
"Subject ID":"44_Corio.O_BA",
"Sample ID":"44_Corio.O_BA_pos",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"44_Corio.O_BA_pos.mzML"}
},
{
"Subject ID":"45_Corio.O_BA",
"Sample ID":"45_Corio.O_BA_pos",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"45_Corio.O_BA_pos.mzML"}
},
{
"Subject ID":"46_O_CD",
"Sample ID":"46_O_CD_pos",
"Factors":{"Diet":"CD","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"46_O_CD_pos.mzML"}
},
{
"Subject ID":"47_Corio.O_HFD.BA",
"Sample ID":"47_Corio.O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"47_Corio.O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"48_Corio.O_HFD.BA",
"Sample ID":"48_Corio.O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"48_Corio.O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"49_Corio.O_HFD.BA",
"Sample ID":"49_Corio.O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"49_Corio.O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"50_Corio.O_HFD",
"Sample ID":"50_Corio.O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"50_Corio.O_HFD_pos.mzML"}
},
{
"Subject ID":"51_Corio.O_HFD",
"Sample ID":"51_Corio.O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"51_Corio.O_HFD_pos.mzML"}
},
{
"Subject ID":"52_Corio.O_HFD",
"Sample ID":"52_Corio.O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"52_Corio.O_HFD_pos.mzML"}
},
{
"Subject ID":"53_Corio.O_HFD",
"Sample ID":"53_Corio.O_HFD_pos",
"Factors":{"Diet":"HFD","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"53_Corio.O_HFD_pos.mzML"}
},
{
"Subject ID":"54_O_BA",
"Sample ID":"54_O_BA_pos",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"54_O_BA_pos.mzML"}
},
{
"Subject ID":"55_O_BA",
"Sample ID":"55_O_BA_pos",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"55_O_BA_pos.mzML"}
},
{
"Subject ID":"56_O_BA",
"Sample ID":"56_O_BA_pos",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"56_O_BA_pos.mzML"}
},
{
"Subject ID":"57_O_BA",
"Sample ID":"57_O_BA_pos",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"57_O_BA_pos.mzML"}
},
{
"Subject ID":"58_O_HFD.BA",
"Sample ID":"58_O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"58_O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"59_O_HFD.BA",
"Sample ID":"59_O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"59_O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"60_O_HFD.BA",
"Sample ID":"60_O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"60_O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"61_O_HFD.BA",
"Sample ID":"61_O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"61_O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"422_Corio.O_BA",
"Sample ID":"422_Corio.O_BA_pos",
"Factors":{"Diet":"BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"422_Corio.O_BA_pos.mzML"}
},
{
"Subject ID":"462_Corio.O_HFD.BA",
"Sample ID":"462_Corio.O_HFD.BA_pos",
"Factors":{"Diet":"HFD.BA","colonization":"Corio_OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"462_Corio.O_HFD.BA_pos.mzML"}
},
{
"Subject ID":"11_6_O_BA",
"Sample ID":"11_6_O_BA_pos",
"Factors":{"Diet":"BA","colonization":"OligoMM"},
"Additional sample data":{"RAW_FILE_NAME":"11+6_O_BA_pos.mzML"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Mice were euthanized with CO2 and colon was extracted.","SAMPLE_TYPE":"Colon"},

"TREATMENT":{"TREATMENT_SUMMARY":"Germfree male C57BL/6N mice were associated with 0.2 ml of the freshly thawed microbial mixtures via oral gavage three times within one week at the age of five weeks. From week 8 onwards, diet was changed from autoclaved standard chow to synthetic control diet (CD) for two weeks. Thereafter, the mice were randomly assigned to four different groups fed the following diets for eight weeks (the references and main differences in composition between the diets are provided in Figure S1B): CD, control diet; CD-BA, control diet supplemented with the primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA) (each 0.1%); HFD, lard-based high-fat diet (48% energy from fat); HFD-BA, HFD supplemented with CA and CDCA. These diets were used due to the link between Coriobacteriia/E. lenta and bile acid metabolism as well as host metabolic health."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Colon content was mixed with 5x ACN:H2O solvent and 4 steel beads for subsequent extraction in the bead mill. After centrifugation, 100 µL of the supernatant were mixed with 500 µL methanol:acetonitrile (ACN):water (2:3:1) followed by vortex and sonication. After centrifugation, 100 µL of the supernatant were dried in a SpeedVac™ vacuum concentrator (Eppendorf, Hamburg, Germany)."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Agilent 1290 Infinity II","COLUMN_NAME":"Agilent ZORBAX Eclipse Plus C18 (100 x 2.1mm,1.8um)","SOLVENT_A":"Water + 0.1% FA","SOLVENT_B":"ACN + 0.1% FA","FLOW_GRADIENT":"0-5.5 min: 1% B; 5-20 min: 1-100% B; 20-22 min: 100% B; 22-22.5: 100-1% B; 22.5-25 min: 1% B","FLOW_RATE":"0.3 ml/min","COLUMN_TEMPERATURE":"45"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 6546 QTOF","INSTRUMENT_TYPE":"QTOF","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"All samples were acquired in positive and negative ionization mode. The QTOF was set up in centroid mode with a scan range of 50 – 1000 m/z. After each full scan, the 2 most intense ions were subjected to fragmentation. The obtained raw data (.d-files) were imported into the Progenesis QI® software (version2.4, Waters Corporation) for further analysis.","MS_RESULTS_FILE":"ST003011_AN004943_Results.txt UNITS:Peak AUC Has m/z:Yes Has RT:Yes RT units:Minutes"}

}