#METABOLOMICS WORKBENCH WanshanLiu_20240120_025238 DATATRACK_ID:4602 STUDY_ID:ST003048 ANALYSIS_ID:AN004999 PROJECT_ID:PR001898
VERSION             	1
CREATED_ON             	January 20, 2024, 5:01 am
#PROJECT
PR:PROJECT_TITLE                 	Identification and validation of serum metabolite biomarkers for endometrial
PR:PROJECT_TITLE                 	cancer diagnosis
PR:PROJECT_TYPE                  	Biomarker, Endometrial cancer, Machine learning, Mass spectrometry, Metabolite
PR:PROJECT_SUMMARY               	Endometrial cancer (EC) stands as the most prevalent gynecological tumor in
PR:PROJECT_SUMMARY               	women worldwide. Notably, differentiation diagnosis of abnormity detected by
PR:PROJECT_SUMMARY               	ultrasound findings (e.g., thickened endometrium or mass in the uterine cavity)
PR:PROJECT_SUMMARY               	is essential and remains challenging in clinical practice. Herein, we identified
PR:PROJECT_SUMMARY               	a metabolic biomarker panel for differentiation diagnosis of EC using machine
PR:PROJECT_SUMMARY               	learning of high-performance serum metabolic fingerprints (SMFs) and validated
PR:PROJECT_SUMMARY               	the biological function. We first recorded the high-performance SMFs of 191 EC
PR:PROJECT_SUMMARY               	and 204 Non-EC subjects via particle-enhanced laser desorption/ionization mass
PR:PROJECT_SUMMARY               	spectrometry (PELDI-MS). Then, we achieved an area-under-the-curve (AUC) of
PR:PROJECT_SUMMARY               	0.957-0.968 for EC diagnosis through machine learning of high-performance SMFs,
PR:PROJECT_SUMMARY               	outperforming the clinical biomarker of cancer antigen 125 (CA-125, AUC of
PR:PROJECT_SUMMARY               	0.610-0.684, P < 0.05). Finally, we identified a metabolic biomarker panel of
PR:PROJECT_SUMMARY               	glutamine, glucose, and cholesterol linoleate with an AUC of 0.901-0.902 and
PR:PROJECT_SUMMARY               	validated the biological function in vitro. Therefore, our work would facilitate
PR:PROJECT_SUMMARY               	the development of novel diagnostic biomarkers for EC in clinics.
PR:INSTITUTE                     	Shanghai Jiao Tong University
PR:DEPARTMENT                    	School of Biomedical Engineering
PR:LAST_NAME                     	Liu
PR:FIRST_NAME                    	Wanshan
PR:ADDRESS                       	1954 Huashan Road, Shanghai, China
PR:EMAIL                         	liuwanshan@sjtu.edu.cn
PR:PHONE                         	+86-13262629289
#STUDY
ST:STUDY_TITLE                   	Identification and validation of serum metabolite biomarkers for endometrial
ST:STUDY_TITLE                   	cancer diagnosis
ST:STUDY_TYPE                    	Biomarker, Endometrial cancer, Machine learning, Mass spectrometry, Metabolite
ST:STUDY_SUMMARY                 	Endometrial cancer (EC) stands as the most prevalent gynecological tumor in
ST:STUDY_SUMMARY                 	women worldwide. Notably, differentiation diagnosis of abnormity detected by
ST:STUDY_SUMMARY                 	ultrasound findings (e.g., thickened endometrium or mass in the uterine cavity)
ST:STUDY_SUMMARY                 	is essential and remains challenging in clinical practice. Herein, we identified
ST:STUDY_SUMMARY                 	a metabolic biomarker panel for differentiation diagnosis of EC using machine
ST:STUDY_SUMMARY                 	learning of high-performance serum metabolic fingerprints (SMFs) and validated
ST:STUDY_SUMMARY                 	the biological function. We first recorded the high-performance SMFs of 191 EC
ST:STUDY_SUMMARY                 	and 204 Non-EC subjects via particle-enhanced laser desorption/ionization mass
ST:STUDY_SUMMARY                 	spectrometry (PELDI-MS). Then, we achieved an area-under-the-curve (AUC) of
ST:STUDY_SUMMARY                 	0.957-0.968 for EC diagnosis through machine learning of high-performance SMFs,
ST:STUDY_SUMMARY                 	outperforming the clinical biomarker of cancer antigen 125 (CA-125, AUC of
ST:STUDY_SUMMARY                 	0.610-0.684, P < 0.05). Finally, we identified a metabolic biomarker panel of
ST:STUDY_SUMMARY                 	glutamine, glucose, and cholesterol linoleate with an AUC of 0.901-0.902 and
ST:STUDY_SUMMARY                 	validated the biological function in vitro. Therefore, our work would facilitate
ST:STUDY_SUMMARY                 	the development of novel diagnostic biomarkers for EC in clinics.
ST:INSTITUTE                     	Shanghai Jiao Tong University
ST:DEPARTMENT                    	School of Biomedical Engineering
ST:LAST_NAME                     	Liu
ST:FIRST_NAME                    	Wanshan
ST:ADDRESS                       	1954 Huashan Road, Shanghai, China
ST:EMAIL                         	liuwanshan@sjtu.edu.cn
ST:PHONE                         	+86-13262629289
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:GENDER                        	Female
#FACTORS
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	1	SMFs-1	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	2	SMFs-2	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	3	SMFs-3	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	4	SMFs-4	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	5	SMFs-5	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	6	SMFs-6	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	7	SMFs-7	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	8	SMFs-8	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	9	SMFs-9	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	10	SMFs-10	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	11	SMFs-11	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	12	SMFs-12	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	13	SMFs-13	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	14	SMFs-14	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	15	SMFs-15	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	16	SMFs-16	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	17	SMFs-17	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	18	SMFs-18	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	19	SMFs-19	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	20	SMFs-20	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	21	SMFs-21	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	22	SMFs-22	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	23	SMFs-23	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	24	SMFs-24	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	25	SMFs-25	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	26	SMFs-26	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	27	SMFs-27	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	28	SMFs-28	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	29	SMFs-29	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	30	SMFs-30	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	31	SMFs-31	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	32	SMFs-32	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	33	SMFs-33	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	34	SMFs-34	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	35	SMFs-35	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	36	SMFs-36	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	37	SMFs-37	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	38	SMFs-38	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	39	SMFs-39	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	40	SMFs-40	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	41	SMFs-41	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	42	SMFs-42	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	43	SMFs-43	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	44	SMFs-44	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	45	SMFs-45	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	46	SMFs-46	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	47	SMFs-47	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	48	SMFs-48	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	49	SMFs-49	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	50	SMFs-50	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	51	SMFs-51	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	52	SMFs-52	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	53	SMFs-53	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	54	SMFs-54	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	55	SMFs-55	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	56	SMFs-56	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	57	SMFs-57	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	58	SMFs-58	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	59	SMFs-59	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	60	SMFs-60	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	61	SMFs-61	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	62	SMFs-62	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	63	SMFs-63	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	64	SMFs-64	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	65	SMFs-65	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	66	SMFs-66	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	67	SMFs-67	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	68	SMFs-68	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	69	SMFs-69	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	70	SMFs-70	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	71	SMFs-71	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	72	SMFs-72	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	73	SMFs-73	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	74	SMFs-74	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	75	SMFs-75	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	76	SMFs-76	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	77	SMFs-77	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	78	SMFs-78	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	79	SMFs-79	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	80	SMFs-80	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	81	SMFs-81	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	82	SMFs-82	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	83	SMFs-83	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	84	SMFs-84	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	85	SMFs-85	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	86	SMFs-86	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	87	SMFs-87	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	88	SMFs-88	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	89	SMFs-89	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	90	SMFs-90	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	91	SMFs-91	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	92	SMFs-92	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	93	SMFs-93	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	94	SMFs-94	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	95	SMFs-95	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	96	SMFs-96	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	97	SMFs-97	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	98	SMFs-98	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	99	SMFs-99	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	100	SMFs-100	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	101	SMFs-101	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	102	SMFs-102	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	103	SMFs-103	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	104	SMFs-104	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	105	SMFs-105	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	106	SMFs-106	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	107	SMFs-107	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	108	SMFs-108	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	109	SMFs-109	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	110	SMFs-110	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	111	SMFs-111	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	112	SMFs-112	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	113	SMFs-113	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	114	SMFs-114	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	115	SMFs-115	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	116	SMFs-116	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	117	SMFs-117	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	118	SMFs-118	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	119	SMFs-119	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	120	SMFs-120	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	121	SMFs-121	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	122	SMFs-122	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	123	SMFs-123	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	124	SMFs-124	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	125	SMFs-125	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	126	SMFs-126	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	127	SMFs-127	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	128	SMFs-128	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	129	SMFs-129	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	130	SMFs-130	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	131	SMFs-131	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	132	SMFs-132	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	133	SMFs-133	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	134	SMFs-134	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	135	SMFs-135	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	136	SMFs-136	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	137	SMFs-137	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	138	SMFs-138	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	139	SMFs-139	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	140	SMFs-140	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	141	SMFs-141	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	142	SMFs-142	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	143	SMFs-143	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	144	SMFs-144	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	145	SMFs-145	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	146	SMFs-146	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	147	SMFs-147	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	148	SMFs-148	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	149	SMFs-149	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	150	SMFs-150	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	151	SMFs-151	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	152	SMFs-152	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	153	SMFs-153	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	154	SMFs-154	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	155	SMFs-155	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	156	SMFs-156	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	157	SMFs-157	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	158	SMFs-158	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	159	SMFs-159	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	160	SMFs-160	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	161	SMFs-161	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	162	SMFs-162	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	163	SMFs-163	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	164	SMFs-164	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	165	SMFs-165	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	166	SMFs-166	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	167	SMFs-167	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	168	SMFs-168	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	169	SMFs-169	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	170	SMFs-170	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	171	SMFs-171	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	172	SMFs-172	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	173	SMFs-173	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	174	SMFs-174	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	175	SMFs-175	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	176	SMFs-176	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	177	SMFs-177	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	178	SMFs-178	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	179	SMFs-179	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	180	SMFs-180	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	181	SMFs-181	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	182	SMFs-182	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	183	SMFs-183	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	184	SMFs-184	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	185	SMFs-185	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	186	SMFs-186	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	187	SMFs-187	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	188	SMFs-188	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	189	SMFs-189	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	190	SMFs-190	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	191	SMFs-191	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	192	SMFs-192	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	193	SMFs-193	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	194	SMFs-194	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	195	SMFs-195	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	196	SMFs-196	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	197	SMFs-197	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	198	SMFs-198	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	199	SMFs-199	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	200	SMFs-200	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	201	SMFs-201	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	202	SMFs-202	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	203	SMFs-203	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	204	SMFs-204	Group:Non-EC	
SUBJECT_SAMPLE_FACTORS           	205	SMFs-205	Group:EC	
SUBJECT_SAMPLE_FACTORS           	206	SMFs-206	Group:EC	
SUBJECT_SAMPLE_FACTORS           	207	SMFs-207	Group:EC	
SUBJECT_SAMPLE_FACTORS           	208	SMFs-208	Group:EC	
SUBJECT_SAMPLE_FACTORS           	209	SMFs-209	Group:EC	
SUBJECT_SAMPLE_FACTORS           	210	SMFs-210	Group:EC	
SUBJECT_SAMPLE_FACTORS           	211	SMFs-211	Group:EC	
SUBJECT_SAMPLE_FACTORS           	212	SMFs-212	Group:EC	
SUBJECT_SAMPLE_FACTORS           	213	SMFs-213	Group:EC	
SUBJECT_SAMPLE_FACTORS           	214	SMFs-214	Group:EC	
SUBJECT_SAMPLE_FACTORS           	215	SMFs-215	Group:EC	
SUBJECT_SAMPLE_FACTORS           	216	SMFs-216	Group:EC	
SUBJECT_SAMPLE_FACTORS           	217	SMFs-217	Group:EC	
SUBJECT_SAMPLE_FACTORS           	218	SMFs-218	Group:EC	
SUBJECT_SAMPLE_FACTORS           	219	SMFs-219	Group:EC	
SUBJECT_SAMPLE_FACTORS           	220	SMFs-220	Group:EC	
SUBJECT_SAMPLE_FACTORS           	221	SMFs-221	Group:EC	
SUBJECT_SAMPLE_FACTORS           	222	SMFs-222	Group:EC	
SUBJECT_SAMPLE_FACTORS           	223	SMFs-223	Group:EC	
SUBJECT_SAMPLE_FACTORS           	224	SMFs-224	Group:EC	
SUBJECT_SAMPLE_FACTORS           	225	SMFs-225	Group:EC	
SUBJECT_SAMPLE_FACTORS           	226	SMFs-226	Group:EC	
SUBJECT_SAMPLE_FACTORS           	227	SMFs-227	Group:EC	
SUBJECT_SAMPLE_FACTORS           	228	SMFs-228	Group:EC	
SUBJECT_SAMPLE_FACTORS           	229	SMFs-229	Group:EC	
SUBJECT_SAMPLE_FACTORS           	230	SMFs-230	Group:EC	
SUBJECT_SAMPLE_FACTORS           	231	SMFs-231	Group:EC	
SUBJECT_SAMPLE_FACTORS           	232	SMFs-232	Group:EC	
SUBJECT_SAMPLE_FACTORS           	233	SMFs-233	Group:EC	
SUBJECT_SAMPLE_FACTORS           	234	SMFs-234	Group:EC	
SUBJECT_SAMPLE_FACTORS           	235	SMFs-235	Group:EC	
SUBJECT_SAMPLE_FACTORS           	236	SMFs-236	Group:EC	
SUBJECT_SAMPLE_FACTORS           	237	SMFs-237	Group:EC	
SUBJECT_SAMPLE_FACTORS           	238	SMFs-238	Group:EC	
SUBJECT_SAMPLE_FACTORS           	239	SMFs-239	Group:EC	
SUBJECT_SAMPLE_FACTORS           	240	SMFs-240	Group:EC	
SUBJECT_SAMPLE_FACTORS           	241	SMFs-241	Group:EC	
SUBJECT_SAMPLE_FACTORS           	242	SMFs-242	Group:EC	
SUBJECT_SAMPLE_FACTORS           	243	SMFs-243	Group:EC	
SUBJECT_SAMPLE_FACTORS           	244	SMFs-244	Group:EC	
SUBJECT_SAMPLE_FACTORS           	245	SMFs-245	Group:EC	
SUBJECT_SAMPLE_FACTORS           	246	SMFs-246	Group:EC	
SUBJECT_SAMPLE_FACTORS           	247	SMFs-247	Group:EC	
SUBJECT_SAMPLE_FACTORS           	248	SMFs-248	Group:EC	
SUBJECT_SAMPLE_FACTORS           	249	SMFs-249	Group:EC	
SUBJECT_SAMPLE_FACTORS           	250	SMFs-250	Group:EC	
SUBJECT_SAMPLE_FACTORS           	251	SMFs-251	Group:EC	
SUBJECT_SAMPLE_FACTORS           	252	SMFs-252	Group:EC	
SUBJECT_SAMPLE_FACTORS           	253	SMFs-253	Group:EC	
SUBJECT_SAMPLE_FACTORS           	254	SMFs-254	Group:EC	
SUBJECT_SAMPLE_FACTORS           	255	SMFs-255	Group:EC	
SUBJECT_SAMPLE_FACTORS           	256	SMFs-256	Group:EC	
SUBJECT_SAMPLE_FACTORS           	257	SMFs-257	Group:EC	
SUBJECT_SAMPLE_FACTORS           	258	SMFs-258	Group:EC	
SUBJECT_SAMPLE_FACTORS           	259	SMFs-259	Group:EC	
SUBJECT_SAMPLE_FACTORS           	260	SMFs-260	Group:EC	
SUBJECT_SAMPLE_FACTORS           	261	SMFs-261	Group:EC	
SUBJECT_SAMPLE_FACTORS           	262	SMFs-262	Group:EC	
SUBJECT_SAMPLE_FACTORS           	263	SMFs-263	Group:EC	
SUBJECT_SAMPLE_FACTORS           	264	SMFs-264	Group:EC	
SUBJECT_SAMPLE_FACTORS           	265	SMFs-265	Group:EC	
SUBJECT_SAMPLE_FACTORS           	266	SMFs-266	Group:EC	
SUBJECT_SAMPLE_FACTORS           	267	SMFs-267	Group:EC	
SUBJECT_SAMPLE_FACTORS           	268	SMFs-268	Group:EC	
SUBJECT_SAMPLE_FACTORS           	269	SMFs-269	Group:EC	
SUBJECT_SAMPLE_FACTORS           	270	SMFs-270	Group:EC	
SUBJECT_SAMPLE_FACTORS           	271	SMFs-271	Group:EC	
SUBJECT_SAMPLE_FACTORS           	272	SMFs-272	Group:EC	
SUBJECT_SAMPLE_FACTORS           	273	SMFs-273	Group:EC	
SUBJECT_SAMPLE_FACTORS           	274	SMFs-274	Group:EC	
SUBJECT_SAMPLE_FACTORS           	275	SMFs-275	Group:EC	
SUBJECT_SAMPLE_FACTORS           	276	SMFs-276	Group:EC	
SUBJECT_SAMPLE_FACTORS           	277	SMFs-277	Group:EC	
SUBJECT_SAMPLE_FACTORS           	278	SMFs-278	Group:EC	
SUBJECT_SAMPLE_FACTORS           	279	SMFs-279	Group:EC	
SUBJECT_SAMPLE_FACTORS           	280	SMFs-280	Group:EC	
SUBJECT_SAMPLE_FACTORS           	281	SMFs-281	Group:EC	
SUBJECT_SAMPLE_FACTORS           	282	SMFs-282	Group:EC	
SUBJECT_SAMPLE_FACTORS           	283	SMFs-283	Group:EC	
SUBJECT_SAMPLE_FACTORS           	284	SMFs-284	Group:EC	
SUBJECT_SAMPLE_FACTORS           	285	SMFs-285	Group:EC	
SUBJECT_SAMPLE_FACTORS           	286	SMFs-286	Group:EC	
SUBJECT_SAMPLE_FACTORS           	287	SMFs-287	Group:EC	
SUBJECT_SAMPLE_FACTORS           	288	SMFs-288	Group:EC	
SUBJECT_SAMPLE_FACTORS           	289	SMFs-289	Group:EC	
SUBJECT_SAMPLE_FACTORS           	290	SMFs-290	Group:EC	
SUBJECT_SAMPLE_FACTORS           	291	SMFs-291	Group:EC	
SUBJECT_SAMPLE_FACTORS           	292	SMFs-292	Group:EC	
SUBJECT_SAMPLE_FACTORS           	293	SMFs-293	Group:EC	
SUBJECT_SAMPLE_FACTORS           	294	SMFs-294	Group:EC	
SUBJECT_SAMPLE_FACTORS           	295	SMFs-295	Group:EC	
SUBJECT_SAMPLE_FACTORS           	296	SMFs-296	Group:EC	
SUBJECT_SAMPLE_FACTORS           	297	SMFs-297	Group:EC	
SUBJECT_SAMPLE_FACTORS           	298	SMFs-298	Group:EC	
SUBJECT_SAMPLE_FACTORS           	299	SMFs-299	Group:EC	
SUBJECT_SAMPLE_FACTORS           	300	SMFs-300	Group:EC	
SUBJECT_SAMPLE_FACTORS           	301	SMFs-301	Group:EC	
SUBJECT_SAMPLE_FACTORS           	302	SMFs-302	Group:EC	
SUBJECT_SAMPLE_FACTORS           	303	SMFs-303	Group:EC	
SUBJECT_SAMPLE_FACTORS           	304	SMFs-304	Group:EC	
SUBJECT_SAMPLE_FACTORS           	305	SMFs-305	Group:EC	
SUBJECT_SAMPLE_FACTORS           	306	SMFs-306	Group:EC	
SUBJECT_SAMPLE_FACTORS           	307	SMFs-307	Group:EC	
SUBJECT_SAMPLE_FACTORS           	308	SMFs-308	Group:EC	
SUBJECT_SAMPLE_FACTORS           	309	SMFs-309	Group:EC	
SUBJECT_SAMPLE_FACTORS           	310	SMFs-310	Group:EC	
SUBJECT_SAMPLE_FACTORS           	311	SMFs-311	Group:EC	
SUBJECT_SAMPLE_FACTORS           	312	SMFs-312	Group:EC	
SUBJECT_SAMPLE_FACTORS           	313	SMFs-313	Group:EC	
SUBJECT_SAMPLE_FACTORS           	314	SMFs-314	Group:EC	
SUBJECT_SAMPLE_FACTORS           	315	SMFs-315	Group:EC	
SUBJECT_SAMPLE_FACTORS           	316	SMFs-316	Group:EC	
SUBJECT_SAMPLE_FACTORS           	317	SMFs-317	Group:EC	
SUBJECT_SAMPLE_FACTORS           	318	SMFs-318	Group:EC	
SUBJECT_SAMPLE_FACTORS           	319	SMFs-319	Group:EC	
SUBJECT_SAMPLE_FACTORS           	320	SMFs-320	Group:EC	
SUBJECT_SAMPLE_FACTORS           	321	SMFs-321	Group:EC	
SUBJECT_SAMPLE_FACTORS           	322	SMFs-322	Group:EC	
SUBJECT_SAMPLE_FACTORS           	323	SMFs-323	Group:EC	
SUBJECT_SAMPLE_FACTORS           	324	SMFs-324	Group:EC	
SUBJECT_SAMPLE_FACTORS           	325	SMFs-325	Group:EC	
SUBJECT_SAMPLE_FACTORS           	326	SMFs-326	Group:EC	
SUBJECT_SAMPLE_FACTORS           	327	SMFs-327	Group:EC	
SUBJECT_SAMPLE_FACTORS           	328	SMFs-328	Group:EC	
SUBJECT_SAMPLE_FACTORS           	329	SMFs-329	Group:EC	
SUBJECT_SAMPLE_FACTORS           	330	SMFs-330	Group:EC	
SUBJECT_SAMPLE_FACTORS           	331	SMFs-331	Group:EC	
SUBJECT_SAMPLE_FACTORS           	332	SMFs-332	Group:EC	
SUBJECT_SAMPLE_FACTORS           	333	SMFs-333	Group:EC	
SUBJECT_SAMPLE_FACTORS           	334	SMFs-334	Group:EC	
SUBJECT_SAMPLE_FACTORS           	335	SMFs-335	Group:EC	
SUBJECT_SAMPLE_FACTORS           	336	SMFs-336	Group:EC	
SUBJECT_SAMPLE_FACTORS           	337	SMFs-337	Group:EC	
SUBJECT_SAMPLE_FACTORS           	338	SMFs-338	Group:EC	
SUBJECT_SAMPLE_FACTORS           	339	SMFs-339	Group:EC	
SUBJECT_SAMPLE_FACTORS           	340	SMFs-340	Group:EC	
SUBJECT_SAMPLE_FACTORS           	341	SMFs-341	Group:EC	
SUBJECT_SAMPLE_FACTORS           	342	SMFs-342	Group:EC	
SUBJECT_SAMPLE_FACTORS           	343	SMFs-343	Group:EC	
SUBJECT_SAMPLE_FACTORS           	344	SMFs-344	Group:EC	
SUBJECT_SAMPLE_FACTORS           	345	SMFs-345	Group:EC	
SUBJECT_SAMPLE_FACTORS           	346	SMFs-346	Group:EC	
SUBJECT_SAMPLE_FACTORS           	347	SMFs-347	Group:EC	
SUBJECT_SAMPLE_FACTORS           	348	SMFs-348	Group:EC	
SUBJECT_SAMPLE_FACTORS           	349	SMFs-349	Group:EC	
SUBJECT_SAMPLE_FACTORS           	350	SMFs-350	Group:EC	
SUBJECT_SAMPLE_FACTORS           	351	SMFs-351	Group:EC	
SUBJECT_SAMPLE_FACTORS           	352	SMFs-352	Group:EC	
SUBJECT_SAMPLE_FACTORS           	353	SMFs-353	Group:EC	
SUBJECT_SAMPLE_FACTORS           	354	SMFs-354	Group:EC	
SUBJECT_SAMPLE_FACTORS           	355	SMFs-355	Group:EC	
SUBJECT_SAMPLE_FACTORS           	356	SMFs-356	Group:EC	
SUBJECT_SAMPLE_FACTORS           	357	SMFs-357	Group:EC	
SUBJECT_SAMPLE_FACTORS           	358	SMFs-358	Group:EC	
SUBJECT_SAMPLE_FACTORS           	359	SMFs-359	Group:EC	
SUBJECT_SAMPLE_FACTORS           	360	SMFs-360	Group:EC	
SUBJECT_SAMPLE_FACTORS           	361	SMFs-361	Group:EC	
SUBJECT_SAMPLE_FACTORS           	362	SMFs-362	Group:EC	
SUBJECT_SAMPLE_FACTORS           	363	SMFs-363	Group:EC	
SUBJECT_SAMPLE_FACTORS           	364	SMFs-364	Group:EC	
SUBJECT_SAMPLE_FACTORS           	365	SMFs-365	Group:EC	
SUBJECT_SAMPLE_FACTORS           	366	SMFs-366	Group:EC	
SUBJECT_SAMPLE_FACTORS           	367	SMFs-367	Group:EC	
SUBJECT_SAMPLE_FACTORS           	368	SMFs-368	Group:EC	
SUBJECT_SAMPLE_FACTORS           	369	SMFs-369	Group:EC	
SUBJECT_SAMPLE_FACTORS           	370	SMFs-370	Group:EC	
SUBJECT_SAMPLE_FACTORS           	371	SMFs-371	Group:EC	
SUBJECT_SAMPLE_FACTORS           	372	SMFs-372	Group:EC	
SUBJECT_SAMPLE_FACTORS           	373	SMFs-373	Group:EC	
SUBJECT_SAMPLE_FACTORS           	374	SMFs-374	Group:EC	
SUBJECT_SAMPLE_FACTORS           	375	SMFs-375	Group:EC	
SUBJECT_SAMPLE_FACTORS           	376	SMFs-376	Group:EC	
SUBJECT_SAMPLE_FACTORS           	377	SMFs-377	Group:EC	
SUBJECT_SAMPLE_FACTORS           	378	SMFs-378	Group:EC	
SUBJECT_SAMPLE_FACTORS           	379	SMFs-379	Group:EC	
SUBJECT_SAMPLE_FACTORS           	380	SMFs-380	Group:EC	
SUBJECT_SAMPLE_FACTORS           	381	SMFs-381	Group:EC	
SUBJECT_SAMPLE_FACTORS           	382	SMFs-382	Group:EC	
SUBJECT_SAMPLE_FACTORS           	383	SMFs-383	Group:EC	
SUBJECT_SAMPLE_FACTORS           	384	SMFs-384	Group:EC	
SUBJECT_SAMPLE_FACTORS           	385	SMFs-385	Group:EC	
SUBJECT_SAMPLE_FACTORS           	386	SMFs-386	Group:EC	
SUBJECT_SAMPLE_FACTORS           	387	SMFs-387	Group:EC	
SUBJECT_SAMPLE_FACTORS           	388	SMFs-388	Group:EC	
SUBJECT_SAMPLE_FACTORS           	389	SMFs-389	Group:EC	
SUBJECT_SAMPLE_FACTORS           	390	SMFs-390	Group:EC	
SUBJECT_SAMPLE_FACTORS           	391	SMFs-391	Group:EC	
SUBJECT_SAMPLE_FACTORS           	392	SMFs-392	Group:EC	
SUBJECT_SAMPLE_FACTORS           	393	SMFs-393	Group:EC	
SUBJECT_SAMPLE_FACTORS           	394	SMFs-394	Group:EC	
SUBJECT_SAMPLE_FACTORS           	395	SMFs-395	Group:EC	
#COLLECTION
CO:COLLECTION_SUMMARY            	Blood was collected through venipuncture and then centrifuged at 2000 g for 10
CO:COLLECTION_SUMMARY            	minutes. The serum was transferred to a microtube immediately and stored at
CO:COLLECTION_SUMMARY            	-80°C. The samples of the EC and Non-EC groups were collected during a similar
CO:COLLECTION_SUMMARY            	period from Dec. 2018 to Sep. 2021, and the serum metabolic fingerprints (SMFs)
CO:COLLECTION_SUMMARY            	database was recorded in Jul. 2022 using the serum samples that underwent one
CO:COLLECTION_SUMMARY            	freeze-thaw cycle. The pathologists were blinded to any information about SMFs
CO:COLLECTION_SUMMARY            	analysis.
CO:SAMPLE_TYPE                   	Blood (serum)
CO:STORAGE_CONDITIONS            	-80℃
#TREATMENT
TR:TREATMENT_SUMMARY             	NA
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	1.5 μL of serum samples (10-fold dilution) were spotted on a 384 polished steel
SP:SAMPLEPREP_SUMMARY            	plate and dried.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	None (Direct infusion)
CH:INSTRUMENT_NAME               	NA
CH:COLUMN_NAME                   	NA
CH:SOLVENT_A                     	NA
CH:SOLVENT_B                     	NA
CH:FLOW_GRADIENT                 	NA
CH:FLOW_RATE                     	NA
CH:COLUMN_TEMPERATURE            	NA
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Bruker Autoflex speed TOF/TOF
MS:INSTRUMENT_TYPE               	TOF
MS:MS_TYPE                       	MALDI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	10 mg of organic matrices were dissolved in 1 mL of TA30 solution
MS:MS_COMMENTS                   	(acetonitrile:0.1% TFA solution, 3:7, v/v), and the particle powder was
MS:MS_COMMENTS                   	dispersed in DIW with 1.0 mg/mL. 1.5 μL of either standard metabolite solutions
MS:MS_COMMENTS                   	or serum samples (10-fold dilution) were spotted on a 384 polished steel plate
MS:MS_COMMENTS                   	and dried. The serum samples were prepared randomly to minimize subjective bias
MS:MS_COMMENTS                   	for the SMFs database construction. Subsequently, matrix solution was added and
MS:MS_COMMENTS                   	dried before detection. Mass-to-charge ratio (m/z) calibration was performed
MS:MS_COMMENTS                   	using alanine, proline, glutamic acid, glucose, lactose, maltotriose, and
MS:MS_COMMENTS                   	thyroxine. The pulse frequency and laser shots per analysis were set to 1000 Hz
MS:MS_COMMENTS                   	and 2000, respectively.
MS:MS_RESULTS_FILE               	ST003048_AN004999_Results.txt	UNITS:Peak intensity	Has m/z:Yes	Has RT:No	RT units:No RT data
#END