{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003155","ANALYSIS_ID":"AN005176","VERSION":"1","CREATED_ON":"April 1, 2024, 9:21 pm"},

"PROJECT":{"PROJECT_TITLE":"NMR-based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages","PROJECT_SUMMARY":"Colorectal cancer (CRC) still remains the leading cause of cancer death worldwide. This study aimed to profile the metabolic differences of colorectal cancer tissues (CCT) at different stages and sites, as compared with their adjacent noncancerous tissues (ANT), to investigate the temporal and spatial heterogeneities of metabolic characterization. Our NMR-based metabolomics fingerprinting revealed that many of the metabolite levels were significantly altered in CCT compared to ANT and esophageal cancer tissues, indicating deregulations of glucose metabolism, one-carbon metabolism, glutamine metabolism, amino acid metabolism, fatty acid metabolism, TCA cycle, choline metabolism, etc. A total of five biomarker metabolites, including glucose, glutamate, alanine, valine and histidine, were identified to distinguish between early and advanced stages of CCT. Metabolites that distinguish the different anatomical sites of CCT include glucose, glycerol, glutamine, inositol, succinate, and citrate. Those significant metabolic differences in CRC tissues at different pathological stages and sites suggested temporal and spatial heterogeneities of metabolic characterization in CCT, providing a metabolic foundation for further study on biofluid metabolism in CRC early detection.","INSTITUTE":"Radiology Department, Second Affiliated Hospital, Shantou University Medical College, Shantou","LAST_NAME":"Lin","FIRST_NAME":"Yan","ADDRESS":"No. 69, Dongxia North Road, Shantou, Guangdong, China, Shantou, Guangdong, China, 515041, China","EMAIL":"994809889@qq.com","PHONE":"+86 18823992148"},

"STUDY":{"STUDY_TITLE":"NMR-based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages","STUDY_SUMMARY":"Colorectal cancer (CRC) still remains the leading cause of cancer death worldwide. This study aimed to profile the metabolic differences of colorectal cancer tissues (CCT) at different stages and sites, as compared with their adjacent noncancerous tissues (ANT), to investigate the temporal and spatial heterogeneities of metabolic characterization. Our NMR-based metabolomics fingerprinting revealed that many of the metabolite levels were significantly altered in CCT compared to ANT and esophageal cancer tissues, indicating deregulations of glucose metabolism, one-carbon metabolism, glutamine metabolism, amino acid metabolism, fatty acid metabolism, TCA cycle, choline metabolism, etc. A total of five biomarker metabolites, including glucose, glutamate, alanine, valine and histidine, were identified to distinguish between early and advanced stages of CCT. Metabolites that distinguish the different anatomical sites of CCT include glucose, glycerol, glutamine, inositol, succinate, and citrate. Those significant metabolic differences in CRC tissues at different pathological stages and sites suggested temporal and spatial heterogeneities of metabolic characterization in CCT, providing a metabolic foundation for further study on biofluid metabolism in CRC early detection.","INSTITUTE":"Radiology Department, Second Affiliated Hospital, Shantou University Medical College, Shantou","LAST_NAME":"Lin","FIRST_NAME":"Yan","ADDRESS":"No. 69, Dongxia North Road, Shantou, Guangdong, China, Shantou, Guangdong, China, 515041, China","EMAIL":"994809889@qq.com","PHONE":"+86 18823992148"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"C_C0_1",
"Sample ID":"CRC-tissue-C0.1.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"CRC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.1.fid"}
},
{
"Subject ID":"C_C0_2",
"Sample ID":"CRC-tissue-C0.2.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.2.fid"}
},
{
"Subject ID":"C_C0_3",
"Sample ID":"CRC-tissue-C0.3.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.3.fid"}
},
{
"Subject ID":"C_C0_4",
"Sample ID":"CRC-tissue-C0.4.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.4.fid"}
},
{
"Subject ID":"C_C0_5",
"Sample ID":"CRC-tissue-C0.5.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.5.fid"}
},
{
"Subject ID":"C_C0_6",
"Sample ID":"CRC-tissue-C0.6.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.6.fid"}
},
{
"Subject ID":"C_C0_7",
"Sample ID":"CRC-tissue-C0.7.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.7.fid"}
},
{
"Subject ID":"C_C0_8",
"Sample ID":"CRC-tissue-C0.8.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.8.fid"}
},
{
"Subject ID":"C_C0_9",
"Sample ID":"CRC-tissue-C0.9.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.9.fid"}
},
{
"Subject ID":"C_C0_10",
"Sample ID":"CRC-tissue-C0.10.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.10.fid"}
},
{
"Subject ID":"C_C0_11",
"Sample ID":"CRC-tissue-C0.11.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.11.fid"}
},
{
"Subject ID":"C_C0_12",
"Sample ID":"CRC-tissue-C0.12.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.12.fid"}
},
{
"Subject ID":"C_C0_13",
"Sample ID":"CRC-tissue-C0.13.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.13.fid"}
},
{
"Subject ID":"C_C0_14",
"Sample ID":"CRC-tissue-C0.14.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"colon"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.14.fid"}
},
{
"Subject ID":"C_C0_15",
"Sample ID":"CRC-tissue-C0.15.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"colon"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.15.fid"}
},
{
"Subject ID":"C_C0_16",
"Sample ID":"CRC-tissue-C0.16.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.16.fid"}
},
{
"Subject ID":"C_C0_17",
"Sample ID":"CRC-tissue-C0.17.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.17.fid"}
},
{
"Subject ID":"C_C0_18",
"Sample ID":"CRC-tissue-C0.18.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.18.fid"}
},
{
"Subject ID":"C_C0_19",
"Sample ID":"CRC-tissue-C0.19.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.19.fid"}
},
{
"Subject ID":"C_C0_20",
"Sample ID":"CRC-tissue-C0.20.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.20.fid"}
},
{
"Subject ID":"C_C0_21",
"Sample ID":"CRC-tissue-C0.21.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.21.fid"}
},
{
"Subject ID":"C_C0_22",
"Sample ID":"CRC-tissue-C0.22.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.22.fid"}
},
{
"Subject ID":"C_C0_23",
"Sample ID":"CRC-tissue-C0.23.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.23.fid"}
},
{
"Subject ID":"C_C0_24",
"Sample ID":"CRC-tissue-C0.24.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.24.fid"}
},
{
"Subject ID":"C_C0_25",
"Sample ID":"CRC-tissue-C0.25.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.25.fid"}
},
{
"Subject ID":"C_C0_26",
"Sample ID":"CRC-tissue-C0.26.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.26.fid"}
},
{
"Subject ID":"C_C0_27",
"Sample ID":"CRC-tissue-C0.27.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.27.fid"}
},
{
"Subject ID":"C_C0_28",
"Sample ID":"CRC-tissue-C0.28.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.28.fid"}
},
{
"Subject ID":"C_C0_29",
"Sample ID":"CRC-tissue-C0.29.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.29.fid"}
},
{
"Subject ID":"C_C0_30",
"Sample ID":"CRC-tissue-C0.30.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.30.fid"}
},
{
"Subject ID":"C_C0_31",
"Sample ID":"CRC-tissue-C0.31.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.31.fid"}
},
{
"Subject ID":"C_C0_32",
"Sample ID":"CRC-tissue-C0.32.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.32.fid"}
},
{
"Subject ID":"C_C0_33",
"Sample ID":"CRC-tissue-C0.33.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.33.fid"}
},
{
"Subject ID":"C_C0_34",
"Sample ID":"CRC-tissue-C0.34.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.34.fid"}
},
{
"Subject ID":"C_C0_35",
"Sample ID":"CRC-tissue-C0.35.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.35.fid"}
},
{
"Subject ID":"C_C0_36",
"Sample ID":"CRC-tissue-C0.36.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.36.fid"}
},
{
"Subject ID":"C_C0_37",
"Sample ID":"CRC-tissue-C0.37.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.37.fid"}
},
{
"Subject ID":"C_C0_38",
"Sample ID":"CRC-tissue-C0.38.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.38.fid"}
},
{
"Subject ID":"C_C0_39",
"Sample ID":"CRC-tissue-C0.39.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.39.fid"}
},
{
"Subject ID":"C_C0_40",
"Sample ID":"CRC-tissue-C0.40.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"CRC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.40.fid"}
},
{
"Subject ID":"C_C0_41",
"Sample ID":"CRC-tissue-C0.41.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.41.fid"}
},
{
"Subject ID":"C_C0_42",
"Sample ID":"CRC-tissue-C0.42.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.42.fid"}
},
{
"Subject ID":"C_C0_43",
"Sample ID":"CRC-tissue-C0.43.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.43.fid"}
},
{
"Subject ID":"C_C0_44",
"Sample ID":"CRC-tissue-C0.44.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.44.fid"}
},
{
"Subject ID":"C_C0_45",
"Sample ID":"CRC-tissue-C0.45.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"CRC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.45.fid"}
},
{
"Subject ID":"C_C0_46",
"Sample ID":"CRC-tissue-C0.46.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.46.fid"}
},
{
"Subject ID":"C_C0_47",
"Sample ID":"CRC-tissue-C0.47.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.47.fid"}
},
{
"Subject ID":"C_C0_48",
"Sample ID":"CRC-tissue-C0.48.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.48.fid"}
},
{
"Subject ID":"C_C0_49",
"Sample ID":"CRC-tissue-C0.49.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"colon"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.49.fid"}
},
{
"Subject ID":"C_C0_50",
"Sample ID":"CRC-tissue-C0.50.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.50.fid"}
},
{
"Subject ID":"C_C0_51",
"Sample ID":"CRC-tissue-C0.51.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.51.fid"}
},
{
"Subject ID":"C_C0_52",
"Sample ID":"CRC-tissue-C0.52.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-C0.52.fid"}
},
{
"Subject ID":"C_P5_1",
"Sample ID":"CRC-tissue-P5.105.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"CRC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.105.fid"}
},
{
"Subject ID":"C_P5_2",
"Sample ID":"CRC-tissue-P5.106.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.106.fid"}
},
{
"Subject ID":"C_P5_3",
"Sample ID":"CRC-tissue-P5.107.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.107.fid"}
},
{
"Subject ID":"C_P5_4",
"Sample ID":"CRC-tissue-P5.108.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.108.fid"}
},
{
"Subject ID":"C_P5_5",
"Sample ID":"CRC-tissue-P5.109.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.109.fid"}
},
{
"Subject ID":"C_P5_6",
"Sample ID":"CRC-tissue-P5.110.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.110.fid"}
},
{
"Subject ID":"C_P5_7",
"Sample ID":"CRC-tissue-P5.111.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.111.fid"}
},
{
"Subject ID":"C_P5_8",
"Sample ID":"CRC-tissue-P5.112.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.112.fid"}
},
{
"Subject ID":"C_P5_9",
"Sample ID":"CRC-tissue-P5.113.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.113.fid"}
},
{
"Subject ID":"C_P5_10",
"Sample ID":"CRC-tissue-P5.114.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.114.fid"}
},
{
"Subject ID":"C_P5_11",
"Sample ID":"CRC-tissue-P5.115.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.115.fid"}
},
{
"Subject ID":"C_P5_12",
"Sample ID":"CRC-tissue-P5.116.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.116.fid"}
},
{
"Subject ID":"C_P5_13",
"Sample ID":"CRC-tissue-P5.117.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.117.fid"}
},
{
"Subject ID":"C_P5_14",
"Sample ID":"CRC-tissue-P5.118.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"CRC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.118.fid"}
},
{
"Subject ID":"C_P5_15",
"Sample ID":"CRC-tissue-P5.119.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.119.fid"}
},
{
"Subject ID":"C_P5_16",
"Sample ID":"CRC-tissue-P5.120.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.120.fid"}
},
{
"Subject ID":"C_P5_17",
"Sample ID":"CRC-tissue-P5.121.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.121.fid"}
},
{
"Subject ID":"C_P5_18",
"Sample ID":"CRC-tissue-P5.122.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.122.fid"}
},
{
"Subject ID":"C_P5_19",
"Sample ID":"CRC-tissue-P5.123.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.123.fid"}
},
{
"Subject ID":"C_P5_20",
"Sample ID":"CRC-tissue-P5.124.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.124.fid"}
},
{
"Subject ID":"C_P5_21",
"Sample ID":"CRC-tissue-P5.125.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.125.fid"}
},
{
"Subject ID":"C_P5_22",
"Sample ID":"CRC-tissue-P5.126.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.126.fid"}
},
{
"Subject ID":"C_P5_23",
"Sample ID":"CRC-tissue-P5.127.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.127.fid"}
},
{
"Subject ID":"C_P5_24",
"Sample ID":"CRC-tissue-P5.128.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.128.fid"}
},
{
"Subject ID":"C_P5_25",
"Sample ID":"CRC-tissue-P5.129.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"early para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.129.fid"}
},
{
"Subject ID":"C_P5_26",
"Sample ID":"CRC-tissue-P5.130.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.130.fid"}
},
{
"Subject ID":"C_P5_27",
"Sample ID":"CRC-tissue-P5.131.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.131.fid"}
},
{
"Subject ID":"C_P5_28",
"Sample ID":"CRC-tissue-P5.132.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.132.fid"}
},
{
"Subject ID":"C_P5_29",
"Sample ID":"CRC-tissue-P5.133.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.133.fid"}
},
{
"Subject ID":"C_P5_30",
"Sample ID":"CRC-tissue-P5.134.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.134.fid"}
},
{
"Subject ID":"C_P5_31",
"Sample ID":"CRC-tissue-P5.135.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.135.fid"}
},
{
"Subject ID":"C_P5_33",
"Sample ID":"CRC-tissue-P5.136.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.136.fid"}
},
{
"Subject ID":"C_P5_34",
"Sample ID":"CRC-tissue-P5.137.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.137.fid"}
},
{
"Subject ID":"C_P5_35",
"Sample ID":"CRC-tissue-P5.138.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.138.fid"}
},
{
"Subject ID":"C_P5_36",
"Sample ID":"CRC-tissue-P5.139.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.139.fid"}
},
{
"Subject ID":"C_P5_37",
"Sample ID":"CRC-tissue-P5.140.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.140.fid"}
},
{
"Subject ID":"C_P5_38",
"Sample ID":"CRC-tissue-P5.141.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.141.fid"}
},
{
"Subject ID":"C_P5_39",
"Sample ID":"CRC-tissue-P5.142.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.142.fid"}
},
{
"Subject ID":"C_P5_40",
"Sample ID":"CRC-tissue-P5.143.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"CRC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.143.fid"}
},
{
"Subject ID":"C_P5_41",
"Sample ID":"CRC-tissue-P5.144.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.144.fid"}
},
{
"Subject ID":"C_P5_42",
"Sample ID":"CRC-tissue-P5.145.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.145.fid"}
},
{
"Subject ID":"C_P5_43",
"Sample ID":"CRC-tissue-P5.146.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.146.fid"}
},
{
"Subject ID":"C_P5_45",
"Sample ID":"CRC-tissue-P5.147.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"CRC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.147.fid"}
},
{
"Subject ID":"C_P5_46",
"Sample ID":"CRC-tissue-P5.148.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.148.fid"}
},
{
"Subject ID":"C_P5_47",
"Sample ID":"CRC-tissue-P5.149.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.149.fid"}
},
{
"Subject ID":"C_P5_48",
"Sample ID":"CRC-tissue-P5.150.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.150.fid"}
},
{
"Subject ID":"C_P5_49",
"Sample ID":"CRC-tissue-P5.151.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"LCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.151.fid"}
},
{
"Subject ID":"C_P5_50",
"Sample ID":"CRC-tissue-P5.152.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"rectum"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.152.fid"}
},
{
"Subject ID":"C_P5_51",
"Sample ID":"CRC-tissue-P5.153.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.153.fid"}
},
{
"Subject ID":"C_P5_52",
"Sample ID":"CRC-tissue-P5.154.fid#",
"Factors":{"Sample source":"Colorectal tissue","Factor":"advanced para-CRC","Factor":"RCC"},
"Additional sample data":{"RAW_FILE_NAME(Raw file name)":"CRC-tissue-P5.154.fid"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Resected colorectal cancer tissues and their corresponding non-cancerous tissues were frozen in liquid nitrogen for 10s before being transferred to cryogenic vials and stored at −80°C until metabolite extraction.","SAMPLE_TYPE":"colorectal tissue","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"None"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Frozen tissue samples (approximately 300 mg) were thawed at 25°C, then sectioned and homogenized at 16,000 rpm for 80 seconds in a solution consisting of 0.6 mL distilled water and 1.2 mL methanol. Subsequently, chloroform (1.2 mL) and distilled water (1.2 mL) were added and the sample was vortexed for 60 seconds. Finally, samples were incubated on ice for 15 mins, followed by centrifugation at 2000 rpm for 5 mins. The resulting supernatant was washed with nitrogen and evaporated before incubating under vacuum for at least 18 hours. The subsequent lyophilized powder was dissolved in 550 μL PBS/D2O buffer (0.1 M, pH 7.4) and 50 μL TSP/D2O stock solution, and after centrifugation at 10,000 rpm for 5 mins,500 μL of the supernatant was transferred to an NMR tube (5 mm size) for 1H NMR spectroscopy analysis."},

"ANALYSIS":{"ANALYSIS_TYPE":"NMR"},

"NM":{"INSTRUMENT_NAME":"Bruker Avance III","INSTRUMENT_TYPE":"FT-NMR","NMR_EXPERIMENT_TYPE":"1D-1H","SPECTROMETER_FREQUENCY":"600 MHz","NMR_RESULTS_FILE":"ST003155_AN005176_Results.txt UNITS:peak area"}

}