#METABOLOMICS WORKBENCH Chemhnbgu24_20240410_081725 DATATRACK_ID:4768 STUDY_ID:ST003175 ANALYSIS_ID:AN005212 PROJECT_ID:PR001974
VERSION             	1
CREATED_ON             	April 18, 2024, 6:11 pm
#PROJECT
PR:PROJECT_TITLE                 	Inactivation of mitochondrial MUL1 E3 ubiquitin ligase inhibits lipogenesis and
PR:PROJECT_TITLE                 	prevents diet-induced obesity in mice
PR:PROJECT_TYPE                  	Basic Research
PR:PROJECT_SUMMARY               	Characterize the role of mitochondrial MUL1 E3-ubiquitin ligase on energy
PR:PROJECT_SUMMARY               	metabolism and lipogenesis using Mul1 deficient, Mul1(-/-), mice. MUL1 protein
PR:PROJECT_SUMMARY               	is involved in mitochondrial dynamics, and innate immune response but its
PR:PROJECT_SUMMARY               	primary function might be the regulation of lipogenesis under conditions of
PR:PROJECT_SUMMARY               	nutritional overload. Using metabolic cages, we monitored whole body energy
PR:PROJECT_SUMMARY               	expenditure, metabolism, and thermoregulation of the Mul1(-/-) mice under
PR:PROJECT_SUMMARY               	standard diet (ND) or high fat diet (HFD). We examined the effect of Mul1
PR:PROJECT_SUMMARY               	inactivation on body weight, HFD-induced adiposity, fatty liver, glucose
PR:PROJECT_SUMMARY               	intolerance, and insulin resistance. We performed global metabolomics,
PR:PROJECT_SUMMARY               	lipidomic, and genome-wide mRNA sequencing using liver from Mul1(+/+) and
PR:PROJECT_SUMMARY               	Mul1(-/-) animals on HFD. The expression level of key proteins involved in
PR:PROJECT_SUMMARY               	lipogenesis and their regulation in the absence of MUL1 was monitored by
PR:PROJECT_SUMMARY               	SDS-PAGE and Western blot analysis. We found that Mul1(-/-) animals have a
PR:PROJECT_SUMMARY               	metabolic phenotype that confers robust resistance to HFD-induced obesity.
PR:PROJECT_SUMMARY               	Several metabolic and lipidomic pathways are perturbed in the liver of Mul1(-/-)
PR:PROJECT_SUMMARY               	animals on HFD, particularly the one driven by Stearoyl-CoA Desaturase 1 (SCD1),
PR:PROJECT_SUMMARY               	a key regulator of lipid metabolism and obesity. In addition, key enzymes
PR:PROJECT_SUMMARY               	involved in lipogenesis and fatty acid oxidation such as ACC1, FASN, AMPK, and
PR:PROJECT_SUMMARY               	CTP1 were also modulated. The concerted deregulation of these enzymes, in the
PR:PROJECT_SUMMARY               	absence of MUL1, causes reduced fat storage and increased fatty acid oxidation.
PR:PROJECT_SUMMARY               	We identified a new function of mitochondrial MUL1 E3 ubiquitin ligase in the
PR:PROJECT_SUMMARY               	regulation of lipogenesis and adiposity, particularly during conditions of HFD.
PR:PROJECT_SUMMARY               	Inactivation of MUL1 provides resistance to HFD-induced obesity and can be a
PR:PROJECT_SUMMARY               	therapeutic target for the treatment of obesity, type 2 diabetes, and
PR:PROJECT_SUMMARY               	nonalcoholic fatty liver disease (NAFLD).
PR:INSTITUTE                     	University of Florida
PR:DEPARTMENT                    	Biochemistry
PR:LABORATORY                    	Merritt's Lab
PR:LAST_NAME                     	Merritt
PR:FIRST_NAME                    	Matthew
PR:ADDRESS                       	SW ARCHER RD, Gainesville, FL 32611
PR:EMAIL                         	rmahar@hnbgu.ac.in
PR:PHONE                         	9557559849
PR:FUNDING_SOURCE                	NIH
PR:CONTRIBUTORS                  	Lucia Cilenti, Jacopo Di Gregorio, Rohit Mahar, Fei Liu, Camilla T. Ambivero,
PR:CONTRIBUTORS                  	Muthu Periasamy, Matthew E. Merrit, and Antonis S. Zervos
#STUDY
ST:STUDY_TITLE                   	Inactivation of mitochondrial MUL1 E3 ubiquitin ligase inhibits lipogenesis and
ST:STUDY_TITLE                   	prevents diet-induced obesity in mice
ST:STUDY_TYPE                    	Basic Research
ST:STUDY_SUMMARY                 	Characterize the role of mitochondrial MUL1 E3-ubiquitin ligase on energy
ST:STUDY_SUMMARY                 	metabolism and lipogenesis using Mul1 deficient, Mul1(-/-), mice. MUL1 protein
ST:STUDY_SUMMARY                 	is involved in mitochondrial dynamics, and innate immune response but its
ST:STUDY_SUMMARY                 	primary function might be the regulation of lipogenesis under conditions of
ST:STUDY_SUMMARY                 	nutritional overload. Using metabolic cages, we monitored whole body energy
ST:STUDY_SUMMARY                 	expenditure, metabolism, and thermoregulation of the Mul1(-/-) mice under
ST:STUDY_SUMMARY                 	standard diet (ND) or high fat diet (HFD). We examined the effect of Mul1
ST:STUDY_SUMMARY                 	inactivation on body weight, HFD-induced adiposity, fatty liver, glucose
ST:STUDY_SUMMARY                 	intolerance, and insulin resistance. We performed global metabolomics,
ST:STUDY_SUMMARY                 	lipidomic, and genome-wide mRNA sequencing using liver from Mul1(+/+) and
ST:STUDY_SUMMARY                 	Mul1(-/-) animals on HFD. The expression level of key proteins involved in
ST:STUDY_SUMMARY                 	lipogenesis and their regulation in the absence of MUL1 was monitored by
ST:STUDY_SUMMARY                 	SDS-PAGE and Western blot analysis. We found that Mul1(-/-) animals have a
ST:STUDY_SUMMARY                 	metabolic phenotype that confers robust resistance to HFD-induced obesity.
ST:STUDY_SUMMARY                 	Several metabolic and lipidomic pathways are perturbed in the liver of Mul1(-/-)
ST:STUDY_SUMMARY                 	animals on HFD, particularly the one driven by Stearoyl-CoA Desaturase 1 (SCD1),
ST:STUDY_SUMMARY                 	a key regulator of lipid metabolism and obesity. In addition, key enzymes
ST:STUDY_SUMMARY                 	involved in lipogenesis and fatty acid oxidation such as ACC1, FASN, AMPK, and
ST:STUDY_SUMMARY                 	CTP1 were also modulated. The concerted deregulation of these enzymes, in the
ST:STUDY_SUMMARY                 	absence of MUL1, causes reduced fat storage and increased fatty acid oxidation.
ST:STUDY_SUMMARY                 	We identified a new function of mitochondrial MUL1 E3 ubiquitin ligase in the
ST:STUDY_SUMMARY                 	regulation of lipogenesis and adiposity, particularly during conditions of HFD.
ST:STUDY_SUMMARY                 	Inactivation of MUL1 provides resistance to HFD-induced obesity and can be a
ST:STUDY_SUMMARY                 	therapeutic target for the treatment of obesity, type 2 diabetes, and
ST:STUDY_SUMMARY                 	nonalcoholic fatty liver disease (NAFLD).
ST:INSTITUTE                     	University of Florida
ST:LAST_NAME                     	Merritt
ST:FIRST_NAME                    	Matthew
ST:ADDRESS                       	SW ARCHER RD, Gainesville, FL 32611
ST:EMAIL                         	rmahar@hnbgu.ac.in
ST:PHONE                         	9557559849
ST:NUM_GROUPS                    	2
ST:TOTAL_SUBJECTS                	12
ST:NUM_MALES                     	6
ST:NUM_FEMALES                   	6
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
SU:GENOTYPE_STRAIN               	Wild type and Mul1(+/+) mice
SU:AGE_OR_AGE_RANGE              	8 weeks
SU:GENDER                        	Male and female
SU:ANIMAL_LIGHT_CYCLE            	12-hour/12-hour light/dark cycle
SU:ANIMAL_FEED                   	Research Diets D12492
#FACTORS
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	Mul1(+/+)_TZ 34	Genotype:Mul1(+/+)  | Sample source:Liver	
SUBJECT_SAMPLE_FACTORS           	-	Mul1(+/+)_TZ 35	Genotype:Mul1(+/+)  | Sample source:Liver	
SUBJECT_SAMPLE_FACTORS           	-	Mul1(+/+)_TZ 36	Genotype:Mul1(+/+)  | Sample source:Liver	
SUBJECT_SAMPLE_FACTORS           	-	Mul1(+/+)_TZ 37	Genotype:Mul1(+/+)  | Sample source:Liver	
SUBJECT_SAMPLE_FACTORS           	-	Mul1(-/-)_TZ 38	Genotype:Mul1(-/-)  | Sample source:Liver	
SUBJECT_SAMPLE_FACTORS           	-	Mul1(-/-)_TZ 39	Genotype:Mul1(-/-)  | Sample source:Liver	
SUBJECT_SAMPLE_FACTORS           	-	Mul1(-/-)_TZ 40	Genotype:Mul1(-/-)  | Sample source:Liver	
SUBJECT_SAMPLE_FACTORS           	-	Mul1(-/-)_TZ 41	Genotype:Mul1(-/-)  | Sample source:Liver	
#COLLECTION
CO:COLLECTION_SUMMARY            	Liver tissue was obtained from Mul1(+/+) and Mul1(-/-) mice following a HFD for
CO:COLLECTION_SUMMARY            	16 weeks and stained with H&E or Oil Red Oil.
CO:SAMPLE_TYPE                   	Liver
CO:STORAGE_CONDITIONS            	-20℃
#TREATMENT
TR:TREATMENT_SUMMARY             	Liver tissue was obtained from Mul1(+/+) and Mul1(-/-) mice following a HFD for
TR:TREATMENT_SUMMARY             	16 weeks and stained with H&E or Oil Red Oil.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	liver tissues from mice were fixed overnight in 10% neutral formalin and
SP:SAMPLEPREP_SUMMARY            	embedded in paraffin. Paraffin-embedded tissues were cut into sections and
SP:SAMPLEPREP_SUMMARY            	stained with hematoxylin and eosin (H&E) for assessment of liver histology.
SP:SAMPLEPREP_SUMMARY            	Liver tissue from Mul1(+/+) and Mul1(-/-) mice on HFD were subjected to the
SP:SAMPLEPREP_SUMMARY            	Folch extraction in order to separate lipids and polar metabolites.
SP:PROCESSING_STORAGE_CONDITIONS 	4℃
SP:EXTRACT_STORAGE               	-20℃
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Thermo Dionex Ultimate 3000
CH:COLUMN_NAME                   	Waters ACQUITY UPLC BEH C18 (100 x 2.1mm,1.7um)
CH:SOLVENT_A                     	60:40 acetonitrile:water; 10mM ammonium formate; 0.1% formic acid
CH:SOLVENT_B                     	90:8:2 2-propanol:acetonitrile:water; 10mM ammonium formate; 0.1% formic acid
CH:FLOW_GRADIENT                 	10 µl/min
CH:FLOW_RATE                     	350 µl/min
CH:COLUMN_TEMPERATURE            	50
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	The aqueous phase was analyzed using the Thermo Q-Exactive Orbitrap mass
MS:MS_COMMENTS                   	spectrometer with Dionex UHPLC and autosampler. All samples were analyzed in
MS:MS_COMMENTS                   	positive and negative simultaneously with heated electrospray ionization (HESI)
MS:MS_COMMENTS                   	with a mass resolution of 35,000 at m/z 200 as separate injections. The polar
MS:MS_COMMENTS                   	metabolites were analyzed on Thermo Q-Exactive Orbitrap mass spectrometer
MS:MS_COMMENTS                   	equipped with UHPLC. Data were analyzed with MZmine and features were aligned
MS:MS_COMMENTS                   	for identification across samples. The metabolites were searched against the
MS:MS_COMMENTS                   	Southeastern Center for Integrated Metabolomics (SECIM) metabolite library using
MS:MS_COMMENTS                   	retention time and corresponding mass spectral data. Lipids isolated from Folch
MS:MS_COMMENTS                   	extraction procedure were also analyzed by the same instrument. Lipidomics data
MS:MS_COMMENTS                   	were analyzed using the LipidMatch software and identified lipid entities were
MS:MS_COMMENTS                   	exported in a tabular form.
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	A.U.
MS_METABOLITE_DATA_START
Samples	Mul1(+/+)_TZ 34	Mul1(+/+)_TZ 35	Mul1(+/+)_TZ 36	Mul1(+/+)_TZ 37	Mul1(-/-)_TZ 38	Mul1(-/-)_TZ 39	Mul1(-/-)_TZ 40	Mul1(-/-)_TZ 41
Factors	Genotype:Mul1(+/+)  | Sample source:Liver	Genotype:Mul1(+/+)  | Sample source:Liver	Genotype:Mul1(+/+)  | Sample source:Liver	Genotype:Mul1(+/+)  | Sample source:Liver	Genotype:Mul1(-/-)  | Sample source:Liver	Genotype:Mul1(-/-)  | Sample source:Liver	Genotype:Mul1(-/-)  | Sample source:Liver	Genotype:Mul1(-/-)  | Sample source:Liver
(R)-Malate_1	31427.39063	61357.54688	145193.5156	107592.1172	95152.55469	98055.72656	134589.4688	90697.1875
(R)-Malate_2	2.47E+08	1074142.75	1522632.625	710100.5	2.55E+08	2.65E+08	3.28E+08	846837.8125
(R)-Malate_3	3.76E+07	3.71E+07	4.26E+07	2.51E+07	3.73E+07	4.65E+07	5.99E+07	4.87E+07
(R)-Malate_4	2.42E+08	2.09E+08	2.58E+08	1.41E+08	2.48E+08	2.65E+08	3.28E+08	2.90E+08
(R,R)-Tartaric Acid	402606.2058	289323.9688	241332.2237	176989.6406	413714.375	234739.5313	262856.2813	253095.4844
(S)-Lactate	6247360.114	7868852.543	1.02E+07	9268465.8	1.01E+07	9763778.343	1.04E+07	8798693.971
11-Prostaglandin F2	551102.9116	254753.0518	249455.7183	112843.6152	255204.4375	280521.2598	138763.9063	159886.3886
12(S)-Hhtre	157938.0643	56894.07422	68012.03906	17808.77539	65647.92969	118931.779	48079.12109	51379.59766
2,5-Dihydroxybenzoate	38231.36719	21168.91406	235690.3772	41024.91016	55066.8125	507282.9866	109858.6424	680960.0018
2-Aminoethyl Dihydrogen Phosphate_1	1032531.125	78974.64632	79195.53103	1016743.188	1624141.375	119537.0214	1866154.75	1523574
2-Aminoethyl Dihydrogen Phosphate_2	992375.7607	1068092.904	1130504.514	949777.2786	1555315.986	1765554.886	1720013.907	1402926.996
2-Aminoethyl Dihydrogen Phosphate_3	2104024.25	1819189	3129992.25	1946615.25	2085423	2164934.5	2248085.5	1943280.125
2-Deoxy-D-Glucose_1	151239.9906	846704.3125	1033146.688	773303.6875	169936.7196	154586.1455	265549.3299	264761.9612
2-Deoxy-D-Glucose_2	3421350.807	2062088.375	2180735.439	1347544.364	1821490.614	1794488.514	2557460.064	1702954.925
2-Hydroxy-4-(Methylthio)Butyric Acid_1	35658.98828	19710.17773	46652.67188	18186.31641	37315.66016	66779.02344	87215.25781	27065.90625
2-Hydroxy-4-(Methylthio)Butyric Acid_2	35658.98828	19710.17773	46652.67188	18186.31641	37315.66016	66779.02344	87215.25781	27065.90625
2-Hydroxy-4-(Methylthio)Butyric Acid_3	212628.3929	225219.0688	186358.8121	119619.9569	187279.1717	204536.8991	581352.6482	184543.7312
2-Hydroxybutyric Acid	6409941.029	4598309.871	7213636.8	5564287.886	1.24E+07	1.47E+07	1.88E+07	2.06E+07
2-Hydroxyglutarate	7650679.229	7611537.571	7522134.3	7515787.029	4612340.6	5784920.929	7578689.257	5842409.514
2-Hydroxyhippuric Acid	137838.3438	52360	63347.08594	141672.5641	25464.25195	30740.83203	114817.0391	83470.03906
2-Hydroxyphenylacetic Acid_1	895287.9946	413294.3348	572667.6402	486176.7134	343483.7071	422061.2786	364811.7	308550.5451
2-Hydroxyphenylacetic Acid_2	894711.875	436978.5313	584517	512899.5938	343613.2188	428354	384310.5938	307182.1563
2-Methylglutaric Acid	25295.74609	11180.0332	8964.799805	7861.426758	9901.529297	24108.06641	61191.72656	18760.36328
3-(4-Hydroxyphenyl)Lactate	4755717.657	1650228.9	3545598.193	2148588.811	5946025.457	6972072.1	7190070.9	3622933.157
3,4-Dihydroxy-L-Phenylalanine	65895.54754	47363.31842	54995.52109	38461.37941	84799.4125	103495.8192	117246.854	80220.00781
3-Hydroxy-3-Methylglutarate	129852.183	124798.2105	132236.3435	150921.7103	269882.642	218836.8929	394775.5527	254222.1835
3-Hydroxyanthranilate	8387.335938	7692.445313	13572.64063	12660.60547	5252.76416	9775.97168	8261.130859	7160.42041
3-Hydroxydecanoic Acid	1886838.061	1393430.857	1662002.964	1868832.336	1857288.993	1594521.454	1506232.654	2176773.407
3-Methyl-2-Oxovaleric Acid	504376.7813	170209.9531	149766.9375	109007.6641	183240.3281	252700.3125	179525.4375	185425.3281
3-Sulfino-L-Alanine	346615.6317	474490.2714	3247646.157	222176.2142	255352.9643	422407.3357	701691.6321	2697930.65
3-Ureidopropionate	1238203.752	1101182.861	2521678.743	1522422.604	405477.75	1601837.746	1190378.634	1410595.961
4-Acetamidobutanoate	30302.96484	18558.04492	38621.77734	51289.49609	32517.72266	33390.33984	36810.55859	27040.94727
4-Aminobenzoate	143286.9359	52911.76953	97860.69531	54216.14453	108048.9063	147661.8942	164859.079	126346.9846
4-Hydroxy-2-Quinolinecarboxylic Acid	272893.892	99045.95313	186829.4888	110037.1478	182626.0357	207055.7848	193675.6116	146073.8321
4-Hydroxybenzenesulfonic Acid	1838196.775	1175172.371	1996318.736	1022369.345	940361.8196	2518069.207	4571301.671	1180967.404
4-Hydroxy-L-Proline_1	271111.8438	200118.8906	172635.5313	123331.8047	255689.1406	535931.8125	469221.8125	154277.8125
4-Hydroxy-L-Proline_2	867253.9429	1276925.1	1202099.318	807479.2929	1622473.268	2046857.743	4594063.664	2004004.35
4-Hydroxyphenylacetate	109321.3033	68417.22656	83903.3125	58261.78125	71446.58594	81954.78125	89272.96875	49492.02344
4-Methyl-2-Oxo-Pentanoic Acid_1	84357.13281	80397.8125	76280.09375	80700.57031	82077.78125	94115.34375	77060.25781	79296.90625
4-Methyl-2-Oxo-Pentanoic Acid_2	507872.0366	310831.1991	149766.9375	159672.0156	308085.6875	493300.5348	266246.9375	254270.0781
4-Oxoproline	7.35E+07	5.50E+07	5.78E+07	6.93E+07	7.28E+07	8.17E+07	1.28E+08	1.42E+08
4-Pyridoxate	7149268.314	5580690.086	5557245.343	4544574.514	8076574.029	7573655.029	7364224.814	8206224.829
5-Oxo-D-Proline	63645.04654	70401	75619.71875	75843.76563	84013.29688	85172.14844	101392.2969	86680.32299
6-Carboxyhexanoate	44259.78125	30757.74805	14613.03516	11739.41016	33294.20313	41847.79297	18455.3418	9461.649414
6-Hydroxycaproic Acid	2452380	1653008.875	2033166.375	1045273.75	1545819.75	1961131.75	2586717.25	1397856.875
6-Keto Prostaglandin F1_1	1174583.371	679307.2089	885863.3125	492879.6179	761221.6598	1483209.211	959477.5	670615.6643
6-Keto Prostaglandin F1_2	1162509.25	539428.5071	864698.1054	382257.6161	784243.75	1097140.355	959477.5	524148.7473
6-Phosphogluconic Acid_1	650627.125	701460.375	1076530.75	1929262.375	1157171.625	1358497.625	1240641.738	1318574
6-Phosphogluconic Acid_2	7849201.214	7242854.943	8386309	9608355.7	6864308.343	5161573.186	1.37E+07	7956626.6
Adenine_1	60210.75	44822.42969	39545.375	26142.12109	83552.84866	63278.83181	87849.59018	64473.46049
Adenine_2	766099.4304	468578.8929	659309.0866	544035.5348	1514913.904	1182282.395	1274441.121	1375629.25
Adenosine	1638942.889	1107372.412	866820.1411	741039.05	1121715.689	1012191.704	873769.0804	986135.5125
Adenosine 3',5'-Diphosphate	518875.9696	631952.5339	1248954.471	1154577.214	1484050.318	1496741.564	2453869.836	1311099.471
Allantoin_1	98103.17188	135205.6563	162502.4375	65150.68359	152690.3594	191965.4844	1055099.168	149664.3438
Allantoin_2	1.68E+07	1.75E+07	1.93E+07	1.73E+07	1.91E+07	1.80E+07	6.31E+07	1.91E+07
Alpha-Aminoadipate_1	66529.91406	123992.6875	185325.7656	205828.9688	129991.2422	40715.62891	801818.5964	213926.25
Alpha-Aminoadipate_2	153710.5625	145317.2344	131681.7031	179290.6094	185749.5781	160247.5313	707504.2821	153618.8438
Alpha-Aminoadipate_3	1064173.164	1193706.63	1721715.807	1546902.518	1807293.789	4599731.407	4.46E+07	4274637.721
Alpha-D-Galactose 1-Phosphate_1	313435.5625	107507.0571	151797.8156	676786.625	214053.2763	225075.5013	210107.5433	142154.8348
Alpha-D-Galactose 1-Phosphate_2	313435.5625	430437.125	244653.5625	676786.625	223501.2969	404499.75	235402.7813	240139.3438
Alpha-D-Galactose 1-Phosphate_3	9113008.886	1.21E+07	7086873.814	1.17E+07	9269487.786	8758322	1.17E+07	1.43E+07
Alpha-D-Galactose 1-Phosphate_4	1.98E+08	1.85E+08	1.79E+08	2.71E+08	1.70E+08	1.50E+08	1.06E+08	1.45E+08
Alpha-Ketoglutaric Acid_1	8493643	868389.325	667580.4554	407376.5357	1126058.123	6935961.5	1.89E+07	591283.675
Alpha-Ketoglutaric Acid_2	8293308.643	4120796.343	3711636.986	4353741.964	5274045.157	6735210.586	1.89E+07	1.15E+07
Arabinose_1	4842321.179	4553597.179	3464414.071	3418183.564	5168479.75	4731419.736	7948814.343	4207441.436
Arabinose_2	6145602.414	6073398.529	3358856.479	4024497.493	5209380.479	5287631.971	3954175.25	4394119.3
Arabinose_3	7715402	6116482.771	5168818.043	5634710.586	5005460.293	5035856.929	5544311.6	5262937.6
Arabinose_4	1.81E+08	1.50E+08	1.71E+08	1.78E+08	2.68E+08	3.81E+08	2.72E+08	2.35E+08
Ascorbate	8528468.014	7208194.4	7867103.557	7689607.386	1.08E+07	1.45E+07	7249653.714	1.36E+07
Azelaic Acid_1	30290.00781	21148.5918	25115.58984	23864.9668	21545.35547	30372.4707	30577.58454	30492.1894
Azelaic Acid_2	26545.5332	23757.58203	29786.29688	16692.35352	29992.87109	20157.33203	39646.58203	39271.06641
Betaine	998464.7804	427702.783	695927.2	1224700.213	646900.3036	345207.9313	1417586.893	2041213.164
Boc-L-Tyrosine_1	7.11E+07	6.83E+07	7.01E+07	6.81E+07	7.39E+07	7.22E+07	6.92E+07	7.00E+07
Boc-L-Tyrosine_2	1.13E+08	1.08E+08	1.10E+08	1.09E+08	1.17E+08	1.13E+08	1.08E+08	1.11E+08
Caffeic Acid	306885.5888	143554.825	83834.04688	170205.9748	580861.4759	208718.8357	244798.2121	200504.2165
Citramalate	545997.6875	410553.9063	783805.6875	234828.0625	438160.6875	664874	702278	685775.4375
Citrate_1	837991.4214	542223.9973	353950.125	378497.5	753204.0179	1181013.564	537499.4375	455184.833
Citrate_2	2.30E+07	1.29E+07	2.37E+07	438893.6563	1.02E+07	932644.475	2.34E+07	2287413.421
Citrulline	178460.2031	135873.1616	204775.8594	121790.0859	144266.3125	132817.9688	194182.5156	130519.3984
Creatine	190384.8752	136936.454	468744.5313	266639.2888	364710.1143	336335.8688	3144895.364	513641.3259
D-(-)-3-Phosphoglyceric Acid_1	2679031.614	2512032.121	5052004.086	1708835.704	1879048.268	3435893.536	1520546.539	4628116.15
D-(-)-3-Phosphoglyceric Acid_2	4575807.829	3966352.5	7733236.914	4205656.571	3199881.686	5405186.029	2111384.111	7574464.743
D-(+)-Cellobiose_1	8.59E+07	6.58E+07	9.68E+07	6.23E+07	8.11E+07	8.69E+07	2.33E+07	8.00E+07
D-(+)-Cellobiose_2	9.78E+07	9.60E+07	9.25E+07	9.21E+07	8.64E+07	8.12E+07	2.35E+07	8.50E+07
D-(+)-Galactosamine	5040112.071	3637269.021	5331515.071	1.71E+07	9409024.186	5254945.886	9850784.714	6382757.714
D-(+)-Galacturonic Acid	974524.375	821754.4375	517176.5	790260.6875	916467	918727.75	748097.8125	688729.375
D-(+)-Raffinose	6.81E+07	6.40E+07	5.39E+07	6.11E+07	5.76E+07	5.64E+07	2254127.5	5.81E+07
D-Aspartate_1	2575187.414	1971431.621	1743498.989	1893573.043	2043369.161	2032673.914	1961192.4	1965168.657
D-Aspartate_2	2.15E+08	1.46E+08	1.41E+08	1.45E+08	1.40E+08	1.30E+08	1.15E+08	1.58E+08
Dehydroascorbate	998539.4518	1004233.813	722695.4089	608194.6554	1199759.938	1174500.232	890923.6929	870662.3089
D-Gluconate	3390256.257	2882370.246	2104215.575	2145831.936	2662700.161	3388520.493	2444890.757	2248049.221
D-Glucuronic Acid	4899607.457	4461104.621	4821528.871	5791709.043	2988350.471	2206882.425	2819246.35	3222586.986
D-Glyceric Acid	4665164.636	4483179.229	5827157.857	5361557.843	6311997.957	9269782.4	1.83E+07	9808872.357
D-Ornithine	9339074.314	5702779.107	6203529.643	5209284.736	7993983.036	7117703.279	7371616.257	6033808.814
D-Saccharic Acid_1	8038197.143	4868105.929	6749739.914	8371357.771	4226024.071	5498127.4	6323882.071	7266359.586
D-Saccharic Acid_2	2.01E+07	1.67E+07	2.37E+07	1.78E+07	1.38E+07	1.24E+07	2.24E+07	2.16E+07
D-Tryptophan_1	306002.9545	230254.3826	210777.7165	193098.975	299629.4036	306989.0732	310631.329	270431.929
D-Tryptophan_2	5.47E+07	4.17E+07	3.55E+07	3.46E+07	5.34E+07	5.62E+07	5.51E+07	5.06E+07
Erythrose 4-Phosphate_1	151104.908	711493.375	898880.3125	785759.5625	432723.3438	453341.875	67726.2567	61363.32746
Erythrose 4-Phosphate_2	676472.6875	711493.375	898880.3125	785759.5625	432723.3438	453341.875	549065.4103	909435
Formyl-L-Methionyl Peptide	169674.45	108899.7123	143106.4616	130358.971	266040.104	290773.0598	279315.8085	208521.2223
Fumarate_1	135695.7607	111385.6873	148972.102	71665.00781	120879.9027	133297.1585	245341.7049	277381.6
Fumarate_2	1027886.598	721324.2054	839959.1714	464349.7241	757492.1571	859093.5696	844192.6	972284.1643
Fumarate_3	2849694.929	2128312.436	3036185.964	922541.3839	2133220.75	2273864.85	2935597.407	3004982.043
Fumarate_4	5.64E+07	4.08E+07	5.32E+07	2.44E+07	4.00E+07	4.46E+07	5.05E+07	5.61E+07
Glucose/Fructose_1	4.94E+07	4.50E+07	2.74E+07	3.25E+07	4.22E+07	3.81E+07	3.42E+07	3.21E+07
Glucose/Fructose_2	6.27E+07	5.78E+07	5.62E+07	5.44E+07	5.14E+07	4.96E+07	1.67E+07	5.35E+07
Glucose/Fructose_3	1.36E+08	1.29E+08	7.41E+07	9.28E+07	1.15E+08	1.03E+08	8.92E+07	9.05E+07
Glucose/Fructose_4	1.53E+08	1.28E+08	1.20E+08	1.05E+08	1.30E+08	1.20E+08	8.38E+07	1.05E+08
Glucose/Fructose_5	4.72E+08	3.92E+08	3.75E+08	3.28E+08	4.11E+08	3.75E+08	2.61E+08	3.28E+08
Glutarate_1	56237.46875	51124.33594	57294.15313	39450.32031	78665.65625	127307.4808	128952.8223	65810.26775
Glutarate_2	1265786.5	968081.625	1193798.375	763732.8125	1733041.811	2588051.586	2557617.714	1457121.25
Glutathione	6.27E+07	6.85E+07	8.02E+07	6.69E+07	3.90E+07	4.22E+07	4.71E+07	3.24E+07
Glyceraldehyde	5839454.5	4697044.5	6893304.243	4644604.5	5798523	7796775.5	8607230.643	6786834
Glycerol 2-Phosphate	2.29E+07	1.58E+07	2.10E+07	4.26E+07	2.01E+07	1.27E+07	2.04E+07	2.69E+07
Glycolaldehyde Dimer	6.95E+07	6.22E+07	6.67E+07	9.14E+07	7.62E+07	7.39E+07	7.50E+07	6.84E+07
Glycolate_1	860966.625	883676.625	627428.9375	709429.875	693167.5464	1069214.546	847245.2732	667772.7071
Glycolate_2	4662284.9	3945217.6	4724519.7	3117923.107	6036984.7	5649159.6	4066492.729	3656187.057
Hexanesulfonic Acid-Sulfate	18894.43164	8740.088867	14772.01563	11911.48828	19118.64844	21121.79688	27093.32813	10748.73926
Hippurate	1.92E+07	5235755.957	7358578.943	4473125.493	4359803.407	7154453.186	6233226.871	3022409.779
Homocysteine	16101.07031	11851.80078	16842.09961	11662.99121	15835.47168	17196.44531	102890.7612	17629.98242
Homoserine_1	396720.7786	369631.1875	571216.5	414850.2188	366493.5147	431775.7201	506203	333163.7188
Homoserine_2	3.67E+07	2.02E+07	1.75E+07	1.48E+07	2.95E+07	2.67E+07	3.54E+07	2.07E+07
Hydroxypyruvate	661823.925	689230.6946	868211.9714	372864.7071	756034.3839	1266091.223	1089963.634	1037880.741
Hypotaurine_1	43743.82422	28150.92969	2471.898438	3142.975342	42511.26172	23214.64453	76543.80469	34934.16797
Hypotaurine_2	2771773.029	921479.2839	1322696.532	1101713.996	2533144.536	3742087.75	2071500.921	729010.9375
Hypoxanthine_1	714322.2589	429601.3036	377546.8402	354360.4295	737955.6196	661326.2143	480285.192	566658.0732
Hypoxanthine_2	1616999.639	1239259.464	1119431.039	1192363.25	1634736.086	1572055.686	1373945.171	1364928.25
Hypoxanthine_3	1.87E+08	1.20E+08	1.03E+08	1.02E+08	1.91E+08	1.71E+08	1.35E+08	1.51E+08
Indole-3-Acetate	41800.72656	27707.99023	37117.75781	26228.59766	33763.92578	40211.95313	38331.66016	34258.54688
Indole-3-Ethanol	1.75E+07	8169801.629	8178358.729	5276231.671	1.06E+07	1.56E+07	1.23E+07	7254174.2
Inosine	8.69E+07	6.09E+07	4.86E+07	5.11E+07	6.02E+07	3.93E+07	4.71E+07	4.32E+07
Isocitric Acid	4034694.05	3216662.679	2385835	1791678.375	3016533.707	1991276.625	3673326.75	1800157.125
Lactate	3.73E+07	3.62E+07	2.06E+07	2.62E+07	3.04E+07	2.76E+07	2.45E+07	2.58E+07
L-Arabitol_1	656800.8375	336657.5625	813113.2857	521355.1563	544672.625	582437.0625	425289.1563	549058.25
L-Arabitol_2	931863.8	712043	645043.9562	624665.242	605298.3536	743678.25	624351.408	683696.6339
L-Asparagine_1	1605754.875	1504490.632	1299739.359	1460888.875	2685889.414	2315742.479	2840548.7	1565278.968
L-Asparagine_2	1.03E+07	8749060.214	8334334.2	8552743.629	1.81E+07	1.44E+07	1.69E+07	1.02E+07
L-Carnitine	1326789.961	1722831.979	1136365.632	1431297.121	1720032.293	3319382.207	3016948.264	427376.1732
L-Cysteine	187390.2188	229034.4063	163002.5313	121997.6563	105408.1328	58697.15234	226474.0469	174239.375
Leucine	1.31E+07	9750647.314	9354882.629	8862465.186	1.36E+07	1.34E+07	1.41E+07	1.16E+07
L-Glutamic Acid_1	1.55E+07	1.22E+07	6416193.014	8983231.4	1.16E+07	8889127.729	1.07E+07	1.01E+07
L-Glutamic Acid_2	4.79E+08	3.72E+08	2.05E+08	2.87E+08	3.46E+08	2.81E+08	3.42E+08	3.08E+08
L-Glutamine_1	98581.8125	145510.3281	153084.7031	120800.7656	400912.4063	415660.3438	246202.1563	184474.25
L-Glutamine_2	1389601.943	1494469.234	753390.3125	694127.1875	2485903.654	2052366.414	2128850.175	1271582.72
L-Glutamine_3	6.76E+07	6.90E+07	3.59E+07	2.88E+07	1.11E+08	8.61E+07	9.40E+07	6.08E+07
L-Histidine	9.13E+07	6.22E+07	5.76E+07	6.89E+07	8.05E+07	8.26E+07	9.32E+07	7.52E+07
L-Isoleucine	3375462.229	2957550.829	2686271.05	2879765.307	3553147.393	3306644.2	3389841.186	2667447.136
L-Lysine	1.71E+07	1.08E+07	1.17E+07	9748708.471	1.68E+07	1.67E+07	1.68E+07	1.27E+07
L-Methionine	3.19E+07	2.62E+07	2.83E+07	2.79E+07	4.00E+07	3.90E+07	4.70E+07	3.35E+07
L-Phenylalanine	6.25E+07	5.09E+07	4.59E+07	4.70E+07	6.02E+07	6.42E+07	7.44E+07	5.37E+07
L-Serine_1	1652664.515	1453673.325	1755827.283	1017354.755	1958614.97	1499612.713	1610837.634	1407845.525
L-Serine_2	2.19E+07	1.67E+07	1.51E+07	1.79E+07	1.93E+07	1.83E+07	2.00E+07	1.66E+07
L-Tyrosine	6.88E+07	5.52E+07	5.34E+07	4.97E+07	7.17E+07	7.41E+07	8.39E+07	6.94E+07
L-Tyrosine-13C6	1797213.507	1839340.968	2053337.275	2142138.386	1812847.55	1919519.989	1817732.996	1786177.407
Lumichrome	375206.4933	228163.5732	154298.1746	151470.3078	232070.6085	214478.2674	109808.2313	122541.2496
L-Valine	2156904.514	1663744.157	2454850.293	2252541.95	3144396.771	3304408.686	3788623.957	2553114.114
Mannitol/Sorbitol	1040349.555	877129.1339	533537.9286	446957.5938	718260.9616	622674.6344	575655.129	422644.979
Mevalolactone	100871.9375	76061.30469	42642.88281	34142.53906	218651.5848	202083.8951	150881.1967	66154.65625
Monobutyl Phthalate_1	6350596.414	6365456.457	6105644.7	4055497.879	7442060.186	6213612.686	6384828.8	7643617.357
Monobutyl Phthalate_2	130669.1172	102955.9063	155966.2344	154952.5661	148329.4688	146508.0938	182067.8442	164452.7031
Monoethyl Phthalate (Mep)	1211829.3	494674.6795	259132.1879	150856.7408	1387970.318	661226.5679	306921.4192	741537.5839
N6-(Delta2-Isopentenyl)-Adenine	2070929.761	1396092.404	1578438.857	1775344.411	1715245.739	2122735.25	2749910.593	1874066.564
N-Acetyl-D-Galactosamine_1	177735.5795	107397.8359	157271.9531	121894.3465	151881.8205	165746.9442	299775.4406	122240.1406
N-Acetyl-D-Galactosamine_2	2360255.843	1402868.164	1900179.832	2169478.571	2315007.293	2614248.229	5101136.057	1640768.121
N-Acetyl-D-Galactosamine_3	7381305.8	3540881.093	7381591.357	4640063.286	5704574.8	6514640.971	1.01E+07	5392113.943
N-Acetyl-Dl-Glutamic Acid_1	245925.6335	142352.5815	817763.8982	156526.0625	303993.9634	484678.5884	1457766.089	549731.5679
N-Acetyl-Dl-Glutamic Acid_2	271361.0652	197219.3504	874961.85	256362.1665	368759.9259	511238.8384	1195305.589	505144.4714
N-Acetyl-Dl-Glutamic Acid_3	1.30E+07	7613050.314	4.43E+07	8857658.9	1.68E+07	2.66E+07	7.77E+07	3.08E+07
N-Acetyl-Dl-Methionine	2.28E+07	1.56E+07	1.44E+07	1.36E+07	2.29E+07	2.43E+07	3.04E+07	2.01E+07
N-Acetyl-Dl-Serine	1448243.5	1245731.125	2411999.75	2065079.375	2518137.5	2309406.25	7.49E+07	1950379.125
N-Acetylglycine	1227653.65	762054.2375	1799400.979	1790252.479	1643933.643	1046641.718	2418494.443	1677457.15
N-Acetyl-L-Alanine_1	1.28E+07	8126796.5	7961620	7273377.5	1.40E+07	1.28E+07	638978.1964	1.11E+07
N-Acetyl-L-Alanine_2	1.26E+07	8049327.114	7977164.729	7268300.686	1.36E+07	1.29E+07	1.15E+07	1.11E+07
N-Acetyl-L-Aspartic Acid_1	1474814.375	823054.625	911219.375	540211.7491	1052619.777	636849.2125	1481442.304	1378991.407
N-Acetyl-L-Aspartic Acid_2	1387109.793	807412.2036	916766.2804	569446.9634	988411.7518	1164395.396	1052949.738	1430040.211
N-Acetyl-L-Cysteine	140617.673	91636.72656	103282.8299	60883.56641	80930.36719	67202.80469	66326.79688	60184.15625
N-Acetyl-L-Leucine_1	4.41E+07	2.79E+07	2.28E+07	1.76E+07	3.83E+07	3.47E+07	3.60E+07	3.13E+07
N-Acetyl-L-Leucine_2	4.44E+07	2.77E+07	2.30E+07	1.76E+07	3.78E+07	3.48E+07	3.55E+07	3.14E+07
N-Acetylneuraminate	2850144.25	3264044.393	2041457.539	1747382.9	3571035.693	4091215.05	4041297.971	2426852.089
N-Boc-L-Aspartic Acid	6.23E+07	5.64E+07	5.32E+07	5.31E+07	6.04E+07	5.77E+07	5.96E+07	5.71E+07
N-Boc-L-Tert-Leucine_1	1.99E+07	1.75E+07	1.85E+07	1.81E+07	1.98E+07	1.86E+07	1.80E+07	1.74E+07
N-Boc-L-Tert-Leucine_2	4.20E+07	3.69E+07	3.97E+07	3.99E+07	4.26E+07	4.00E+07	3.87E+07	3.79E+07
N-Boc-L-Tryptophan_1	4.75E+07	4.63E+07	4.73E+07	4.49E+07	4.97E+07	4.58E+07	4.73E+07	4.80E+07
N-Boc-L-Tryptophan_2	5.44E+07	5.24E+07	5.60E+07	4.99E+07	5.68E+07	5.18E+07	5.41E+07	5.30E+07
Nicotinamide_1	159878.7969	127657.4922	121760.9141	89321.92969	141851.9688	131315.1239	146930.2969	133403.9375
Nicotinamide_2	255087.9281	215050.2464	175611.8616	146706.017	229187.6067	234801.992	234386.6063	226016.4839
Nicotinate	251331.7656	218697.0469	252035.2813	317557.5313	239678.9375	250656.6719	387813.5313	207918.8281
Orotate	780274.4464	538074.6607	1176721.007	346434.817	1552076.15	6302607.371	7587980.714	5249127.043
O-Succinyl-L-Homoserine	159890.0022	129730.7895	135035.5138	141349.8342	142779.0542	180176.9406	174305.4991	142029.9714
Proline	919876.2875	447701.1518	373075.9625	483406.5187	705266.6732	709682.3036	1061140.195	530403.25
Pterin	1503254.825	1195001.582	908878.8589	575914.4661	2131051.139	2018098.004	1515957.075	1324236.129
Pyridine-2,3-Dicarboxylate	628529.125	661718.5	503171.7813	484984.5938	351517.5313	692199.75	688146.9375	533985.5625
Pyridoxal	155485.5402	94995.95313	105354.4234	79926.66406	296758.6638	156622.5002	83046.1875	58300.22266
Pyridoxamine	6593538.621	5850729.386	7756069.986	5550227.207	6680719.107	8307915.996	9266508.45	6542375.332
Pyruvate_1	121692.6333	89033.13594	90808.41295	57699.14844	113603.3685	137694.8391	123994.931	119122.5089
Pyruvate_2	1.54E+08	1.98E+08	1.75E+08	6.89E+07	2.73E+08	2.98E+08	2.80E+08	2.24E+08
Quinate	477351.0625	208120.1875	713397.5625	123444.8984	284394.5938	233397.5313	187529.5	140285.5625
Quinolinic Acid	628529.125	661718.5	503171.7813	484984.5938	511630.3125	725211.125	721347.25	60296.26948
Salicylic Acid-D4	7.15E+07	5.44E+07	6.23E+07	7.25E+07	7.54E+07	7.19E+07	6.89E+07	5.60E+07
Sarcosine/Beta-Alanine	6174298.514	4367674.929	4188000.886	4412187.064	4075309.429	4301118.25	4837740.379	4893595.264
Sn-Glycero-3-Phosphocholine	2910516.707	3672561.629	4114391.507	1.51E+07	4402459.614	3144973.404	8489468.271	2997184.271
Succinate_1	77696.76563	68339.16406	39458.71094	16315.10156	39346.76563	49885.4375	164148.0871	55936.41797
Succinate_2	157359.625	144587.0313	120965.4297	93174.59375	116625.6953	133961.2031	195421	142884.3906
Succinate_3	7898921.614	6771836.429	4973904.314	2890288.557	5393528.2	6112926.914	1.14E+07	6497879.7
Taurine_1	1.33E+07	2.85E+07	2.24E+07	1.96E+07	1.43E+07	2.27E+07	1.77E+07	3.79E+07
Taurine_2	4.41E+08	5.92E+08	4.25E+08	4.06E+08	4.46E+08	5.13E+08	3.94E+08	5.92E+08
Thymine	298708.2504	145845.9411	106900.0408	109276.3016	184746.5879	195672.1254	187570.8826	235069.9366
Trans-Aconitate	69879.98438	45498.5	108758.9063	54750.37109	41400.91244	21407.7793	110307.5156	21743.04883
Trehalose/Sucrose	8.14E+07	7.87E+07	7.82E+07	7.60E+07	7.02E+07	6.73E+07	1.74E+07	7.09E+07
Uracil	7.96E+07	7.33E+07	6.09E+07	4.88E+07	8.82E+07	9.49E+07	8.59E+07	7.95E+07
Uridine	1.50E+08	6.94E+07	9.40E+07	9.22E+07	1.43E+08	1.63E+08	1.36E+08	1.36E+08
Xanthine	4.02E+08	3.56E+08	3.10E+08	2.76E+08	3.72E+08	3.99E+08	3.89E+08	4.01E+08
Xanthosine	3.59E+07	3.52E+07	2.92E+07	3.16E+07	2.90E+07	2.90E+07	3.97E+07	2.90E+07
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name
(R)-Malate_1
(R)-Malate_2
(R)-Malate_3
(R)-Malate_4
(R,R)-Tartaric Acid
(S)-Lactate
11-Prostaglandin F2
12(S)-Hhtre
2,5-Dihydroxybenzoate
2-Aminoethyl Dihydrogen Phosphate_1
2-Aminoethyl Dihydrogen Phosphate_2
2-Aminoethyl Dihydrogen Phosphate_3
2-Deoxy-D-Glucose_1
2-Deoxy-D-Glucose_2
2-Hydroxy-4-(Methylthio)Butyric Acid_1
2-Hydroxy-4-(Methylthio)Butyric Acid_2
2-Hydroxy-4-(Methylthio)Butyric Acid_3
2-Hydroxybutyric Acid
2-Hydroxyglutarate
2-Hydroxyhippuric Acid
2-Hydroxyphenylacetic Acid_1
2-Hydroxyphenylacetic Acid_2
2-Methylglutaric Acid
3-(4-Hydroxyphenyl)Lactate
3,4-Dihydroxy-L-Phenylalanine
3-Hydroxy-3-Methylglutarate
3-Hydroxyanthranilate
3-Hydroxydecanoic Acid
3-Methyl-2-Oxovaleric Acid
3-Sulfino-L-Alanine
3-Ureidopropionate
4-Acetamidobutanoate
4-Aminobenzoate
4-Hydroxy-2-Quinolinecarboxylic Acid
4-Hydroxybenzenesulfonic Acid
4-Hydroxy-L-Proline_1
4-Hydroxy-L-Proline_2
4-Hydroxyphenylacetate
4-Methyl-2-Oxo-Pentanoic Acid_1
4-Methyl-2-Oxo-Pentanoic Acid_2
4-Oxoproline
4-Pyridoxate
5-Oxo-D-Proline
6-Carboxyhexanoate
6-Hydroxycaproic Acid
6-Keto Prostaglandin F1_1
6-Keto Prostaglandin F1_2
6-Phosphogluconic Acid_1
6-Phosphogluconic Acid_2
Adenine_1
Adenine_2
Adenosine
Adenosine 3',5'-Diphosphate
Allantoin_1
Allantoin_2
Alpha-Aminoadipate_1
Alpha-Aminoadipate_2
Alpha-Aminoadipate_3
Alpha-D-Galactose 1-Phosphate_1
Alpha-D-Galactose 1-Phosphate_2
Alpha-D-Galactose 1-Phosphate_3
Alpha-D-Galactose 1-Phosphate_4
Alpha-Ketoglutaric Acid_1
Alpha-Ketoglutaric Acid_2
Arabinose_1
Arabinose_2
Arabinose_3
Arabinose_4
Ascorbate
Azelaic Acid_1
Azelaic Acid_2
Betaine
Boc-L-Tyrosine_1
Boc-L-Tyrosine_2
Caffeic Acid
Citramalate
Citrate_1
Citrate_2
Citrulline
Creatine
D-(-)-3-Phosphoglyceric Acid_1
D-(-)-3-Phosphoglyceric Acid_2
D-(+)-Cellobiose_1
D-(+)-Cellobiose_2
D-(+)-Galactosamine
D-(+)-Galacturonic Acid
D-(+)-Raffinose
D-Aspartate_1
D-Aspartate_2
Dehydroascorbate
D-Gluconate
D-Glucuronic Acid
D-Glyceric Acid
D-Ornithine
D-Saccharic Acid_1
D-Saccharic Acid_2
D-Tryptophan_1
D-Tryptophan_2
Erythrose 4-Phosphate_1
Erythrose 4-Phosphate_2
Formyl-L-Methionyl Peptide
Fumarate_1
Fumarate_2
Fumarate_3
Fumarate_4
Glucose/Fructose_1
Glucose/Fructose_2
Glucose/Fructose_3
Glucose/Fructose_4
Glucose/Fructose_5
Glutarate_1
Glutarate_2
Glutathione
Glyceraldehyde
Glycerol 2-Phosphate
Glycolaldehyde Dimer
Glycolate_1
Glycolate_2
Hexanesulfonic Acid-Sulfate
Hippurate
Homocysteine
Homoserine_1
Homoserine_2
Hydroxypyruvate
Hypotaurine_1
Hypotaurine_2
Hypoxanthine_1
Hypoxanthine_2
Hypoxanthine_3
Indole-3-Acetate
Indole-3-Ethanol
Inosine
Isocitric Acid
Lactate
L-Arabitol_1
L-Arabitol_2
L-Asparagine_1
L-Asparagine_2
L-Carnitine
L-Cysteine
Leucine
L-Glutamic Acid_1
L-Glutamic Acid_2
L-Glutamine_1
L-Glutamine_2
L-Glutamine_3
L-Histidine
L-Isoleucine
L-Lysine
L-Methionine
L-Phenylalanine
L-Serine_1
L-Serine_2
L-Tyrosine
L-Tyrosine-13C6
Lumichrome
L-Valine
Mannitol/Sorbitol
Mevalolactone
Monobutyl Phthalate_1
Monobutyl Phthalate_2
Monoethyl Phthalate (Mep)
N6-(Delta2-Isopentenyl)-Adenine
N-Acetyl-D-Galactosamine_1
N-Acetyl-D-Galactosamine_2
N-Acetyl-D-Galactosamine_3
N-Acetyl-Dl-Glutamic Acid_1
N-Acetyl-Dl-Glutamic Acid_2
N-Acetyl-Dl-Glutamic Acid_3
N-Acetyl-Dl-Methionine
N-Acetyl-Dl-Serine
N-Acetylglycine
N-Acetyl-L-Alanine_1
N-Acetyl-L-Alanine_2
N-Acetyl-L-Aspartic Acid_1
N-Acetyl-L-Aspartic Acid_2
N-Acetyl-L-Cysteine
N-Acetyl-L-Leucine_1
N-Acetyl-L-Leucine_2
N-Acetylneuraminate
N-Boc-L-Aspartic Acid
N-Boc-L-Tert-Leucine_1
N-Boc-L-Tert-Leucine_2
N-Boc-L-Tryptophan_1
N-Boc-L-Tryptophan_2
Nicotinamide_1
Nicotinamide_2
Nicotinate
Orotate
O-Succinyl-L-Homoserine
Proline
Pterin
Pyridine-2,3-Dicarboxylate
Pyridoxal
Pyridoxamine
Pyruvate_1
Pyruvate_2
Quinate
Quinolinic Acid
Salicylic Acid-D4
Sarcosine/Beta-Alanine
Sn-Glycero-3-Phosphocholine
Succinate_1
Succinate_2
Succinate_3
Taurine_1
Taurine_2
Thymine
Trans-Aconitate
Trehalose/Sucrose
Uracil
Uridine
Xanthine
Xanthosine
METABOLITES_END
#END