{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003264","ANALYSIS_ID":"AN005348","PROJECT_ID":"PR002026","VERSION":"1","CREATED_ON":"June 17, 2024, 5:26 pm"},

"PROJECT":{"PROJECT_TITLE":"SLC25A48 controls mitochondrial choline import and metabolism","PROJECT_SUMMARY":"Choline is an essential nutrient for cellular metabolism, including the biosynthesis of phospholipids, neurotransmitters, and one-carbon metabolism. A critical step in choline catabolism is the mitochondrial import and synthesis of choline-derived methyl donors, such as betaine. However, the underlying mechanisms and the biological significance of mitochondrial choline metabolism remain poorly understood. Here, we report that a previously uncharacterized mitochondrial inner-membrane protein, SLC25A48, controls mitochondrial choline transport and catabolism in vivo. We show that SLC25A48 is highly expressed in brown adipose tissue and is required for whole-body cold tolerance, thermogenesis, mitochondrial respiration, and mitochondrial membrane integrity. Choline uptake into the mitochondria via SLC25A48 facilitates the synthesis of betaine and purine nucleotides, whereas loss of SLC25A48 resulted in increased production of reactive oxygen species and imbalanced mitochondrial lipids. Notably, human cells carrying a single nucleotide polymorphism on the SLC25A48 gene and cancer cells lacking SLC25A48 exhibited elevated oxidative stress and impaired cell proliferation. Together, the present study identified SLC25A48 as a mitochondrial carrier that mediates choline catabolism and plays a critical role in mitochondrial function and cell survival.","INSTITUTE":"Beth Israel Deaconess Medical Center","LAST_NAME":"Verkerke","FIRST_NAME":"Anthony","ADDRESS":"330 Brookline Avenue, Boston, Massachusetts, 02215, USA","EMAIL":"averkerk@bidmc.harvard.edu","PHONE":"7159231910"},

"STUDY":{"STUDY_TITLE":"SLC25A48 controls mitochondrial choline import and metabolism","STUDY_SUMMARY":"Choline is an essential nutrient for cellular metabolism, including the biosynthesis of phospholipids, neurotransmitters, and one-carbon metabolism. A critical step in choline catabolism is the mitochondrial import and synthesis of choline-derived methyl donors, such as betaine. However, the underlying mechanisms and the biological significance of mitochondrial choline metabolism remain poorly understood. Here, we report that a previously uncharacterized mitochondrial inner-membrane protein, SLC25A48, controls mitochondrial choline transport and catabolism in vivo. We show that SLC25A48 is highly expressed in brown adipose tissue and is required for whole-body cold tolerance, thermogenesis, mitochondrial respiration, and mitochondrial membrane integrity. Choline uptake into the mitochondria via SLC25A48 facilitates the synthesis of betaine and purine nucleotides, whereas loss of SLC25A48 resulted in increased production of reactive oxygen species and imbalanced mitochondrial lipids. Notably, human cells carrying a single nucleotide polymorphism on the SLC25A48 gene and cancer cells lacking SLC25A48 exhibited elevated oxidative stress and impaired cell proliferation. Together, the present study identified SLC25A48 as a mitochondrial carrier that mediates choline catabolism and plays a critical role in mitochondrial function and cell survival.","INSTITUTE":"Harvard Medical School","LAST_NAME":"Verkerke","FIRST_NAME":"Anthony","ADDRESS":"330 Brookline Avenue, CLS 730","EMAIL":"averkerk@bidmc.harvard.edu","PHONE":"7159231910"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENDER":"Male"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Serum_1",
"Factors":{"Genoptye":"Control","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_1.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_2",
"Factors":{"Genoptye":"Control","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_2.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_3",
"Factors":{"Genoptye":"Control","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_3.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_4",
"Factors":{"Genoptye":"Control","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_4.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_5",
"Factors":{"Genoptye":"Control","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_5.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_6",
"Factors":{"Genoptye":"Control","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_6.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_7",
"Factors":{"Genoptye":"Control","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_7.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_8",
"Factors":{"Genoptye":"Control","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_8.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_9",
"Factors":{"Genoptye":"SLC25A48-KO","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_9.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_10",
"Factors":{"Genoptye":"SLC25A48-KO","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_10.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_11",
"Factors":{"Genoptye":"SLC25A48-KO","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_11.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_12",
"Factors":{"Genoptye":"SLC25A48-KO","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_12.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_13",
"Factors":{"Genoptye":"SLC25A48-KO","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_13.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_14",
"Factors":{"Genoptye":"SLC25A48-KO","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_14.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_15",
"Factors":{"Genoptye":"SLC25A48-KO","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_15.RAW"}
},
{
"Subject ID":"-",
"Sample ID":"Serum_16",
"Factors":{"Genoptye":"SLC25A48-KO","Sample source":"Serum"},
"Additional sample data":{"RAW_FILE_NAME":"Serum_16.RAW"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Standard chow fed mice were fasted for four hours prior to serum or tissue collection.","SAMPLE_TYPE":"Serum"},

"TREATMENT":{"TREATMENT_SUMMARY":"Samples are from wild-type or SLC25A48-KO male mice fed a standard chow diet. Mice were fasted for four hours prior to sample collection."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"10 µL serum was mixed with 90 µL extraction solvent of methanol: acetonitrile: water 40: 40: 20 at -20 ˚C, and then vigorously vortexed. All samples were then conditioned to -4 ˚C, and centrifuged at 16,000 rpm/min. The supernatant was transferred to LC-MS tubes for analysis."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Waters XBridge BEH Amide XP Column (150 x 2.1mm, 2.5um) with guard column (5mm x 2.1mm, 2.5 µm)","CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Thermo Vanquish","COLUMN_NAME":"Waters XBridge BEH Amide XP (150 x 2.1mm, 2.5um)","SOLVENT_A":"95% Water, 5% Acetonitrile; 10 mM ammonium acetate and 10 mM ammonium hydroxide","SOLVENT_B":"20% Water, 80% Acetonitrile; 10 mM ammonium acetate and 10 mM ammonium hydroxide","FLOW_GRADIENT":"0 - 3 min, 100% B; 3.2 - 6.2 min, 90% B; 6.5 - 10.5 min, 80% B; 10.7 - 13.5 min, 70% B; 13.7 - 16 min, 45% B; and 16.5 - 22 min, 100% B","FLOW_RATE":"0.3 mL/ min","COLUMN_TEMPERATURE":"4˚C"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive HF","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"UNSPECIFIED","MS_COMMENTS":"The mass spectrometry used was Q Exactive HF (Thermo Fisher Scientific, San Jose, CA), and scanned from 70 to 1000 m/z with switching polarity. The resolution was 120,000. Metabolites were identified based on accurate mass and retention time using an in-house library, and the software used was EI-Maven (Elucidata, Cambridge, MA)."},

"MS_METABOLITE_DATA":{
"Units":"Peak area",

"Data":[{"Metabolite":"Glycine","Serum_1":"1225430","Serum_2":"2320490.75","Serum_3":"1779886.62","Serum_4":"2194564.25","Serum_5":"2097928.5","Serum_6":"1515518","Serum_7":"1748514.12","Serum_8":"985511.19","Serum_9":"1433609.62","Serum_10":"1154625","Serum_11":"2000670.88","Serum_12":"1662599.5","Serum_13":"3147505","Serum_14":"1508015.38","Serum_15":"1857567.12","Serum_16":"1341462.5"},{"Metabolite":"Pyruvate","Serum_1":"23924456","Serum_2":"32530288","Serum_3":"27897256","Serum_4":"28749728","Serum_5":"23914318","Serum_6":"33709308","Serum_7":"45257248","Serum_8":"16863430","Serum_9":"20940762","Serum_10":"30035338","Serum_11":"37011460","Serum_12":"30044382","Serum_13":"28872898","Serum_14":"28634270","Serum_15":"23025056","Serum_16":"33156634"},{"Metabolite":"Alanine","Serum_1":"6153598.5","Serum_2":"12505721","Serum_3":"5792692","Serum_4":"6671501.5","Serum_5":"7369422.5","Serum_6":"6649625.5","Serum_7":"6900876","Serum_8":"4180097.75","Serum_9":"6809190","Serum_10":"6305382.5","Serum_11":"6944698.5","Serum_12":"7618906.5","Serum_13":"10712536","Serum_14":"5455919.5","Serum_15":"6637168","Serum_16":"4714727.5"},{"Metabolite":"Lactate","Serum_1":"897720512","Serum_2":"1421378560","Serum_3":"740421120","Serum_4":"1074212992","Serum_5":"942787392","Serum_6":"986395456","Serum_7":"944792768","Serum_8":"494441504","Serum_9":"917643456","Serum_10":"907844096","Serum_11":"776189376","Serum_12":"1173278336","Serum_13":"1133771904","Serum_14":"529590912","Serum_15":"641828544","Serum_16":"932300224"},{"Metabolite":"Acetoacetate","Serum_1":"2522249.75","Serum_2":"1199765.38","Serum_3":"3614415","Serum_4":"2821719.75","Serum_5":"1881129.62","Serum_6":"1303955","Serum_7":"1545122","Serum_8":"3027213","Serum_9":"1248155.5","Serum_10":"1598518.12","Serum_11":"4179529.25","Serum_12":"2082808.38","Serum_13":"1644289.62","Serum_14":"3434839.75","Serum_15":"2751486.75","Serum_16":"1855312.38"},{"Metabolite":"N-Formylglycine","Serum_1":"48213.83","Serum_2":"194062.7","Serum_3":"40914.44","Serum_4":"39255.39","Serum_5":"60000.55","Serum_6":"53730.72","Serum_7":"87635.46","Serum_8":"44512.47","Serum_9":"47868.86","Serum_10":"67911.65","Serum_11":"80048.59","Serum_12":"45528.39","Serum_13":"40386.44","Serum_14":"38875.89","Serum_15":"54144.69","Serum_16":"42294.77"},{"Metabolite":"3-Hydroxybutyric acid","Serum_1":"36672364","Serum_2":"17791076","Serum_3":"23687864","Serum_4":"38528308","Serum_5":"20304638","Serum_6":"15974096","Serum_7":"12474229","Serum_8":"27003798","Serum_9":"15072616","Serum_10":"13457024","Serum_11":"33158678","Serum_12":"24499342","Serum_13":"21835544","Serum_14":"25903686","Serum_15":"29239418","Serum_16":"27354544"},{"Metabolite":"3-hydroxyisobutyric acid","Serum_1":"7627331.5","Serum_2":"7363322.5","Serum_3":"6746913.5","Serum_4":"12512789","Serum_5":"9473919","Serum_6":"12315915","Serum_7":"11506080","Serum_8":"6742092","Serum_9":"3978191","Serum_10":"6218531.5","Serum_11":"10984764","Serum_12":"8416761","Serum_13":"9533439","Serum_14":"8506153","Serum_15":"11908183","Serum_16":"7660634.5"},{"Metabolite":"Serine","Serum_1":"5331298.5","Serum_2":"8674439","Serum_3":"5543226","Serum_4":"5900095.5","Serum_5":"5856850.5","Serum_6":"4595102","Serum_7":"4689342.5","Serum_8":"4012436.25","Serum_9":"5545843","Serum_10":"4290497.5","Serum_11":"7951633.5","Serum_12":"5727254.5","Serum_13":"8747435","Serum_14":"3444635.75","Serum_15":"5220254.5","Serum_16":"3510365.75"},{"Metabolite":"Glycerate","Serum_1":"360339.25","Serum_2":"557153.06","Serum_3":"499962","Serum_4":"520945.5","Serum_5":"510668.09","Serum_6":"609595.06","Serum_7":"804318.06","Serum_8":"435740.59","Serum_9":"412617.5","Serum_10":"556681.31","Serum_11":"495700.12","Serum_12":"521573.91","Serum_13":"500766.38","Serum_14":"531999.12","Serum_15":"584590.69","Serum_16":"653914.44"},{"Metabolite":"Fumarate","Serum_1":"902034.31","Serum_2":"3514500.75","Serum_3":"1428043.5","Serum_4":"1571090.38","Serum_5":"1614615.5","Serum_6":"2330940.75","Serum_7":"2119228","Serum_8":"1109031.38","Serum_9":"1925452","Serum_10":"1407355","Serum_11":"1077858","Serum_12":"1222593.12","Serum_13":"2365343","Serum_14":"1292742.62","Serum_15":"1533362.38","Serum_16":"1769987.38"},{"Metabolite":"3-methyl-2-oxobutyrate","Serum_1":"9568652","Serum_2":"8155066.5","Serum_3":"8929957","Serum_4":"10307959","Serum_5":"9992607","Serum_6":"9297685","Serum_7":"9828153","Serum_8":"7790877.5","Serum_9":"8306737.5","Serum_10":"12021008","Serum_11":"9666099","Serum_12":"8345210.5","Serum_13":"9098435","Serum_14":"7309150","Serum_15":"7939652","Serum_16":"8579067"},{"Metabolite":"N-Acetylglycine","Serum_1":"9592261","Serum_2":"7316222","Serum_3":"6987802.5","Serum_4":"11737080","Serum_5":"9162757","Serum_6":"8158904","Serum_7":"5969186","Serum_8":"4704361.5","Serum_9":"8459385","Serum_10":"6559688","Serum_11":"9402489","Serum_12":"8637463","Serum_13":"7870204","Serum_14":"6130729.5","Serum_15":"6163034.5","Serum_16":"6921804.5"},{"Metabolite":"Guanidineacetic Acid","Serum_1":"20098.93","Serum_2":"34530.57","Serum_3":"13606.94","Serum_4":"13946.6","Serum_5":"22800.01","Serum_6":"25237.63","Serum_7":"29815.38","Serum_8":"17543.12","Serum_9":"19925.82","Serum_10":"22186.01","Serum_11":"36279.94","Serum_12":"27979.98","Serum_13":"42039.3","Serum_14":"41619.27","Serum_15":"43552.34","Serum_16":"26750.56"},{"Metabolite":"Valine","Serum_1":"5599345.5","Serum_2":"9047671","Serum_3":"9656912","Serum_4":"8440485","Serum_5":"9836693","Serum_6":"8965237","Serum_7":"8987136","Serum_8":"5674174.5","Serum_9":"6655985.5","Serum_10":"7795145.5","Serum_11":"8341627.5","Serum_12":"8559016","Serum_13":"7982160","Serum_14":"4592457.5","Serum_15":"8133518.5","Serum_16":"5890592"},{"Metabolite":"Succinic 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"Metabolites":[{"Metabolite":"Glycine","PubChem":"750","KEGG":"C00037"},{"Metabolite":"Pyruvate","PubChem":"1060","KEGG":"C00022"},{"Metabolite":"Alanine","PubChem":"602","KEGG":"C01401"},{"Metabolite":"Lactate","PubChem":"107689","KEGG":"C00186"},{"Metabolite":"Acetoacetate","PubChem":"96","KEGG":"C00164"},{"Metabolite":"N-Formylglycine","PubChem":" 75606  ","KEGG":"-"},{"Metabolite":"3-Hydroxybutyric acid","PubChem":"441","KEGG":"C01089"},{"Metabolite":"3-hydroxyisobutyric acid","PubChem":"440873","KEGG":"C06001"},{"Metabolite":"Serine","PubChem":"5951","KEGG":"C00065"},{"Metabolite":"Glycerate","PubChem":"439194","KEGG":"C00258"},{"Metabolite":"Fumarate","PubChem":"444972","KEGG":"C00122"},{"Metabolite":"3-methyl-2-oxobutyrate","PubChem":"49","KEGG":"C00141"},{"Metabolite":"N-Acetylglycine","PubChem":"10972","KEGG":"-"},{"Metabolite":"Guanidineacetic Acid","PubChem":"763","KEGG":"C00581"},{"Metabolite":"Valine","PubChem":"6287","KEGG":"C00183"},{"Metabolite":"Succinic 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acid","PubChem":"111","KEGG":"C02642"},{"Metabolite":"Asparagine","PubChem":"6267","KEGG":"C00152"},{"Metabolite":"Aspartate","PubChem":"5960","KEGG":"C00049"},{"Metabolite":"Malate","PubChem":"222656","KEGG":"C00149"},{"Metabolite":"Urocanate","PubChem":"736715","KEGG":"C00785"},{"Metabolite":"O-Phosphoryethanolamine","PubChem":"1015","KEGG":"-"},{"Metabolite":"3-Methylglutaconate","PubChem":"1551553","KEGG":"-"},{"Metabolite":"Alpha-Ketoglutarate","PubChem":"51","KEGG":"C00026"},{"Metabolite":"Glutamate","PubChem":"33032","KEGG":"C00025"},{"Metabolite":"N-Acetyl-serine","PubChem":" 65249 ","KEGG":"-"},{"Metabolite":"Citramalate","PubChem":"1081","KEGG":"C00815"},{"Metabolite":"Orotate","PubChem":"967","KEGG":"C00295"},{"Metabolite":"Dihydroorotic acid","PubChem":"648 ","KEGG":"-"},{"Metabolite":"Allantoin","PubChem":"204","KEGG":"C02350"},{"Metabolite":"N-Methyl-L-glutamate","PubChem":"439377","KEGG":"C01046"},{"Metabolite":"3-Hydroxy-3-methylglutarate","PubChem":"1662","KEGG":"C03761"},{"Metabolite":"Fucose","PubChem":"17106","KEGG":"C01019"},{"Metabolite":"Phenylalanine","PubChem":"6140","KEGG":"C00079"},{"Metabolite":"Uric acid","PubChem":"1175","KEGG":"C00366"},{"Metabolite":"Dihydroxyacetone phosphate","PubChem":"668","KEGG":"C00111"},{"Metabolite":"Glycerol 3-phosphate","PubChem":"439162","KEGG":"C00093"},{"Metabolite":"N-Acetyl-Leucine","PubChem":"70912  ","KEGG":"-"},{"Metabolite":"cis-aconitic acid","PubChem":"643757","KEGG":"C00417"},{"Metabolite":"N-Acetyl-aspartate","PubChem":"53630516 ","KEGG":"-"},{"Metabolite":"Citrulline","PubChem":"9750","KEGG":"C00327"},{"Metabolite":"Hippuric acid","PubChem":"464","KEGG":"C01586"},{"Metabolite":"Glucose","PubChem":"5793","KEGG":"C00031"},{"Metabolite":"Tyrosine","PubChem":"6057","KEGG":"C00082"},{"Metabolite":"Homovanillic acid","PubChem":"1738","KEGG":"C05582"},{"Metabolite":"Galactitol","PubChem":"11850","KEGG":"C01697"},{"Metabolite":"Acetylglutamine","PubChem":"182230","KEGG":"-"},{"Metabolite":"N-Acetyl-glutamate","PubChem":"70914","KEGG":"-"},{"Metabolite":"Acetylmethionine","PubChem":"448580","KEGG":"C02712"},{"Metabolite":"Citrate","PubChem":"311","KEGG":"C00158"},{"Metabolite":"Glucuronic acid","PubChem":"444791","KEGG":"C00191"},{"Metabolite":"methyl beta-D-galactopyranoside","PubChem":"94214  ","KEGG":"-"},{"Metabolite":"Gluconate","PubChem":"10690","KEGG":"C00257"},{"Metabolite":"Sebacic acid","PubChem":"5192","KEGG":"C08277"},{"Metabolite":"Tryptophan","PubChem":"6305","KEGG":"C00078"},{"Metabolite":"Indolelactate","PubChem":"676157","KEGG":"C02043"},{"Metabolite":"N-Acetyl-L-phenylalanine","PubChem":"74839","KEGG":"C03519"},{"Metabolite":"O-Succinyl-L-Homoserine","PubChem":" 439406  ","KEGG":"-"},{"Metabolite":"Pantothenate","PubChem":"6613","KEGG":"C00864"},{"Metabolite":"Ribose 5-phosphate","PubChem":"440101","KEGG":"C00117"},{"Metabolite":"Thymidine","PubChem":"5789","KEGG":"C00214"},{"Metabolite":"Uridine","PubChem":"6029","KEGG":"C00299"},{"Metabolite":"N-acetyl-L-tryptophan","PubChem":"700653","KEGG":"-"},{"Metabolite":"Fructose 6-phosphate","PubChem":"69507","KEGG":"C00085"},{"Metabolite":"Glucose 6-phosphate","PubChem":"5958","KEGG":"C00092"},{"Metabolite":"Retinyl acetate","PubChem":"10245972","KEGG":"-"},{"Metabolite":"Betaine","PubChem":"247","KEGG":"C00719"},{"Metabolite":"Choline","PubChem":"305","KEGG":"C00114"},{"Metabolite":"Dimethylglycine","PubChem":"673","KEGG":"C01026"},{"Metabolite":"Sarcosine","PubChem":"1088","KEGG":"C00213"},{"Metabolite":"Hypotaurine","PubChem":"107812","KEGG":"C00519"},{"Metabolite":"histamine","PubChem":"774","KEGG":"C00388"},{"Metabolite":"Proline","PubChem":"145742","KEGG":"C00148"},{"Metabolite":"Nicotinamide","PubChem":"936","KEGG":"C00153"},{"Metabolite":"pipecolinic acid","PubChem":"849","KEGG":"C00408"},{"Metabolite":"Creatine","PubChem":"586","KEGG":"C00300"},{"Metabolite":"Ornithine","PubChem":"6262","KEGG":"C00077"},{"Metabolite":"Methylnicotinamide","PubChem":"64950 ","KEGG":"-"},{"Metabolite":"Glutamine","PubChem":"5961","KEGG":"C00064"},{"Metabolite":"Lysine","PubChem":"5962","KEGG":"C00047"},{"Metabolite":"Methionine","PubChem":"6137","KEGG":"C00073"},{"Metabolite":"Aminoadipate","PubChem":"92136","KEGG":"C00956"},{"Metabolite":"Carnitine","PubChem":"10917","KEGG":"C00487"},{"Metabolite":"3-methyl-histidine","PubChem":"64969 ","KEGG":"-"},{"Metabolite":"Arginine","PubChem":"6322","KEGG":"C00062"},{"Metabolite":"Guanidinosuccinic acid","PubChem":"439918","KEGG":"C03139"},{"Metabolite":"Serotonin","PubChem":"5202","KEGG":"C00780"},{"Metabolite":"Glucosamine","PubChem":"439213","KEGG":"C00329"},{"Metabolite":"N-Acetyl-lysine","PubChem":"265949","KEGG":"-"},{"Metabolite":"Homoarginine","PubChem":"9085","KEGG":"C01924"},{"Metabolite":"Trimethyllysine","PubChem":"440120","KEGG":"C03793"},{"Metabolite":"Homocitrulline","PubChem":"65072","KEGG":"C02427"},{"Metabolite":"Asymmetric dimethylarginine","PubChem":"123831","KEGG":"C03626"},{"Metabolite":"O-Acetyl-L-carnitine","PubChem":"7045767","KEGG":"C02571"},{"Metabolite":"Kynurenine","PubChem":"161166","KEGG":"C00328"},{"Metabolite":"Creatine Phosphate","PubChem":"587","KEGG":"C02305"},{"Metabolite":"gamma-glutamyl-alanine","PubChem":"440103","KEGG":"-"},{"Metabolite":"Carnosine","PubChem":"439224","KEGG":"C00386"},{"Metabolite":"Cystine","PubChem":"67678","KEGG":"-"},{"Metabolite":"Anserine","PubChem":"112072","KEGG":"C01262"},{"Metabolite":"Cytidine","PubChem":"6175","KEGG":"C00475"},{"Metabolite":"Biotin","PubChem":"171548","KEGG":"C00120"},{"Metabolite":"Glycerophosphocholine","PubChem":"657272","KEGG":"C00670"},{"Metabolite":"Adenosine","PubChem":"60961","KEGG":"C00212"},{"Metabolite":"Glutaryl-carnitine","PubChem":"71317118  ","KEGG":"-"},{"Metabolite":"S-Adenosyl-homocysteine","PubChem":"439155","KEGG":"C00021"},{"Metabolite":"S-Adenosylmethionine","PubChem":"34756","KEGG":"C00019"},{"Metabolite":"Palmitoyl-Carnitine","PubChem":" 461 ","KEGG":"-"}]
}

}