{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003282","ANALYSIS_ID":"AN005377","PROJECT_ID":"PR002034","VERSION":"1","CREATED_ON":"February 15, 2024, 9:10 pm"},

"PROJECT":{"PROJECT_TITLE":"High Throughput Metabolomics using 96-plex Isotope Tagging","PROJECT_SUMMARY":"Chemical tags with 96 unique masses are reported which alleviate the metabolomic workflow bottleneck and allow for absolute quantitation. A metabolic screen for carboxylic acids was performed on mammalian cells deprived of various nutrients and showed 24% RSD and analysis of 288 samples in 2 hours.","INSTITUTE":"Saint Louis University","DEPARTMENT":"Chemistry","LAST_NAME":"Armbruster","FIRST_NAME":"Michael","ADDRESS":"3501 Laclede Ave, St Louis, MO 63103","EMAIL":"armbrustermr@gmail.com","PHONE":"3145501620","FUNDING_SOURCE":"5R01GM134081"},

"STUDY":{"STUDY_TITLE":"96-plex metabolomics studies on nutrient-deprived endothelial cells","STUDY_SUMMARY":"A NeuCode tag which allows for cost efficient incorporation of isotopes is used to enable a 96-plex assay for small molecule metabolomics. A 96-well plate of cell lysates is analyzed simultaneously, providing absolute quantitation of 38 metabolites across 96 samples in a single LC-MS injection.","INSTITUTE":"Saint Louis University","LAST_NAME":"Armbruster","FIRST_NAME":"Michael","ADDRESS":"4448 Swiss Stone Ln E Apt 3C, Ypsilanti, Michigan, 48197, USA","EMAIL":"armbrustermr@gmail.com","PHONE":"3145501620"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Bos taurus","TAXONOMY_ID":"9913"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"ctrl_1_1hr",
"Factors":{"Treatment":"ctrl_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_2_1hr",
"Factors":{"Treatment":"ctrl_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_3_1hr",
"Factors":{"Treatment":"ctrl_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_1_1hr",
"Factors":{"Treatment":"gln_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_2_1hr",
"Factors":{"Treatment":"gln_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_3_1hr",
"Factors":{"Treatment":"gln_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_1_1hr",
"Factors":{"Treatment":"gluc_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_2_1hr",
"Factors":{"Treatment":"gluc_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_3_1hr",
"Factors":{"Treatment":"gluc_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_1_1hr",
"Factors":{"Treatment":"pyr_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_2_1hr",
"Factors":{"Treatment":"pyr_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_3_1hr",
"Factors":{"Treatment":"pyr_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_1_1hr",
"Factors":{"Treatment":"gln_gluc_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_2_1hr",
"Factors":{"Treatment":"gln_gluc_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_3_1hr",
"Factors":{"Treatment":"gln_gluc_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_1_1hr",
"Factors":{"Treatment":"gln_pyr_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_2_1hr",
"Factors":{"Treatment":"gln_pyr_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_3_1hr",
"Factors":{"Treatment":"gln_pyr_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_1_1hr",
"Factors":{"Treatment":"gluc_pyr_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_2_1hr",
"Factors":{"Treatment":"gluc_pyr_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_3_1hr",
"Factors":{"Treatment":"gluc_pyr_1hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_1_4hr",
"Factors":{"Treatment":"ctrl_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_2_4hr",
"Factors":{"Treatment":"ctrl_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_3_4hr",
"Factors":{"Treatment":"ctrl_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_1_4hr",
"Factors":{"Treatment":"gln_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_2_4hr",
"Factors":{"Treatment":"gln_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_3_4hr",
"Factors":{"Treatment":"gln_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_1_4hr",
"Factors":{"Treatment":"gluc_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_2_4hr",
"Factors":{"Treatment":"gluc_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_3_4hr",
"Factors":{"Treatment":"gluc_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_1_4hr",
"Factors":{"Treatment":"pyr_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_2_4hr",
"Factors":{"Treatment":"pyr_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_3_4hr",
"Factors":{"Treatment":"pyr_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_1_4hr",
"Factors":{"Treatment":"gln_gluc_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_2_4hr",
"Factors":{"Treatment":"gln_gluc_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_3_4hr",
"Factors":{"Treatment":"gln_gluc_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_1_4hr",
"Factors":{"Treatment":"gln_pyr_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_2_4hr",
"Factors":{"Treatment":"gln_pyr_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_3_4hr",
"Factors":{"Treatment":"gln_pyr_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_1_4hr",
"Factors":{"Treatment":"gluc_pyr_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_2_4hr",
"Factors":{"Treatment":"gluc_pyr_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_3_4hr",
"Factors":{"Treatment":"gluc_pyr_4hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_1_8hr",
"Factors":{"Treatment":"ctrl_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_2_8hr",
"Factors":{"Treatment":"ctrl_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_3_8hr",
"Factors":{"Treatment":"ctrl_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_1_8hr",
"Factors":{"Treatment":"gln_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_2_8hr",
"Factors":{"Treatment":"gln_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_3_8hr",
"Factors":{"Treatment":"gln_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_1_8hr",
"Factors":{"Treatment":"gluc_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_2_8hr",
"Factors":{"Treatment":"gluc_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_3_8hr",
"Factors":{"Treatment":"gluc_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_1_8hr",
"Factors":{"Treatment":"pyr_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_2_8hr",
"Factors":{"Treatment":"pyr_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_3_8hr",
"Factors":{"Treatment":"pyr_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_1_8hr",
"Factors":{"Treatment":"gln_gluc_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_2_8hr",
"Factors":{"Treatment":"gln_gluc_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_3_8hr",
"Factors":{"Treatment":"gln_gluc_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_1_8hr",
"Factors":{"Treatment":"gln_pyr_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_2_8hr",
"Factors":{"Treatment":"gln_pyr_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_3_8hr",
"Factors":{"Treatment":"gln_pyr_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_1_8hr",
"Factors":{"Treatment":"gluc_pyr_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_2_8hr",
"Factors":{"Treatment":"gluc_pyr_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_3_8hr",
"Factors":{"Treatment":"gluc_pyr_8hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_1_24hr",
"Factors":{"Treatment":"ctrl_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_2_24hr",
"Factors":{"Treatment":"ctrl_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"ctrl_3_24hr",
"Factors":{"Treatment":"ctrl_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_1_24hr",
"Factors":{"Treatment":"gln_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_2_24hr",
"Factors":{"Treatment":"gln_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_3_24hr",
"Factors":{"Treatment":"gln_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_1_24hr",
"Factors":{"Treatment":"gluc_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_2_24hr",
"Factors":{"Treatment":"gluc_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_3_24hr",
"Factors":{"Treatment":"gluc_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_1_24hr",
"Factors":{"Treatment":"pyr_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_2_24hr",
"Factors":{"Treatment":"pyr_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"pyr_3_24hr",
"Factors":{"Treatment":"pyr_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_1_24hr",
"Factors":{"Treatment":"gln_gluc_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_2_24hr",
"Factors":{"Treatment":"gln_gluc_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_gluc_3_24hr",
"Factors":{"Treatment":"gln_gluc_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_1_24hr",
"Factors":{"Treatment":"gln_pyr_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_2_24hr",
"Factors":{"Treatment":"gln_pyr_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gln_pyr_3_24hr",
"Factors":{"Treatment":"gln_pyr_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_1_24hr",
"Factors":{"Treatment":"gluc_pyr_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_A.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_2_24hr",
"Factors":{"Treatment":"gluc_pyr_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_B.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"gluc_pyr_3_24hr",
"Factors":{"Treatment":"gluc_pyr_24hr","Sample source":"BAEC"},
"Additional sample data":{"RAW_FILE_NAME":"nDeP_96Plex_C.mzML"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Cell culture media was removed and the cells were rinsed 3x with PBS using an 8-channel pipette. Lysing solution (100µL of 80/20 ACN/H2O)) was added and the cells were put over ice. The wells were flush-mixed 10 times, sonicated for 5 minutes, then centrifuged at 3,400 rpm for 10 minutes at 10 ºC. The supernatant was then transferred to a 96-well plate containing 200µg of pre-aliquoted tag in each well.","SAMPLE_TYPE":"Endothelial cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"Bulk bovine aortic endothelial cells were cultured in complete media. These bulk plates were used to seed 96-well plates at 40,000 cells per well in 200µL of media. These cultures were maintained for 24 hours in complete media supplemented with 10% FBS before nutrient deprivation. Triplicate controls were included at every time point and were media swapped to complete media + 10% dialyzed FBS. Triplicate 96-well plates were used for nutrient deprivation experiments, and a separate plate was cultured for cell counting using a hemocytometer following manufacturer instructions. Tags were allocated to different wells to reduce bias caused by tag interactions. A single row (B) was left empty during culture. These wells were used to create a calibration curve for each analyte centered around the approximate biological concentration in controls."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"DMTMM mediated coupling of amine tags to biological acids is well studied and previous reports were used as a basis for acid tagging. Briefly, the coupling of biological acids to the amine tag was initiated with the addition of 25µL of a DMTMM/NMM solution (75mM DMTMM, 100mM NMM in 95/5 ACN/H2O)). The 96-well plate was allowed to react for 30 minutes at room temperature before another addition (12.5µL) of DMTMM/NMM to ensure reaction completion and account for water-mediated DMTMM degradation. After 4 hours total reaction time, 50µL of 50mM myristic acid was added and allowed to react for an additional 30 minutes to quench the reaction. All 96 well lysates are mixed into a 15mL falcon tube after the reaction is quenched. This reaction solution is mixed 1:1 with chloroform, vortexed for 30s, then centrifuged at 2,000 rpm for 5 minutes to ensure phase separation. The top aqueous layer is then taken for WCX enrichment. Supelclean 500 mg WCX columns were used to selectively enrich quaternary amine-tagged metabolites. Columns were conditioned with 4 mL of 90/10 (MeOH/H2O) and then equilibrated with 4 mL of loading buffer (10% MeOH in 20mM ammonium formate pH 8.5). The extracted reaction solution was mixed 1:1 with loading buffer before injection. The column was then rinsed with 4 mL of loading buffer, followed by elution with 8 mL of 90/10 (MeOH/H2O) + 1% formic acid. While singly tagged analytes readily elute at mL 2-3 under these conditions, doubly tagged analytes require more fractions to be collected. The first 1mL of this elution was discarded and the rest were pooled, dried, and reconstituted into 50µL of 25/25/50 (MeOH/H2O/ACN) to ensure solubility of all tagged analytes."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Thermo Vanquish","COLUMN_NAME":"Waters ACQUITY UPLC BEH Amide (150 x 2.1mm,1.7um)","SOLVENT_A":"10/90 ACN/H2)","SOLVENT_B":"95/5 ACN/H2O","FLOW_GRADIENT":"0–1 min, 100% B; 6 min, 45% B; 8.5 min, 45% B; 8.6 – 18 min, 0% B","FLOW_RATE":"300µL/min","COLUMN_TEMPERATURE":"50"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Orbitrap ID-X tribrid","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"The IDX was operated with an isolation width of 12 m/z, maximum injection time of 502 ms, AGC of 1e6, positive spray voltage of 3.5 kV, sheath gas of 50 arbitrary units (Arb), aux gas of 10 Arb, sweep gas of 1 Arb, a vaporizer temperature of 350 ºC, and a capillary temperature of 325 ºC."},

"MS_METABOLITE_DATA":{
"Units":"nM",

"Data":[{"Metabolite":"(+/-)-3-methyl-2-oxovaleric acid sodium salt","ctrl_1_1hr":"398.3135632","ctrl_2_1hr":"623.6422268","ctrl_3_1hr":"494.8065929","gln_1_1hr":"324.5948383","gln_2_1hr":"251.6179188","gln_3_1hr":"433.2801276","gln_gluc_1_1hr":"175.3380382","gln_gluc_2_1hr":"293.0201579","gln_gluc_3_1hr":"705.7208838","gln_pyr_1_1hr":"NA","gln_pyr_2_1hr":"117.4341478","gln_pyr_3_1hr":"13.97164483","gluc_1_1hr":"189.1614987","gluc_2_1hr":"291.0413765","gluc_3_1hr":"281.6431893","gluc_pyr_1_1hr":"49.74883982","gluc_pyr_2_1hr":"69.76773931","gluc_pyr_3_1hr":"3.19770888","pyr_1_1hr":"NA","pyr_2_1hr":"110.8714308","pyr_3_1hr":"8.891433269","ctrl_1_4hr":"NA","ctrl_2_4hr":"49.41255142","ctrl_3_4hr":"91.72820493","gln_1_4hr":"273.1255439","gln_2_4hr":"469.2264831","gln_3_4hr":"291.9952329","gln_gluc_1_4hr":"50.2286743","gln_gluc_2_4hr":"46.90348783","gln_gluc_3_4hr":"248.3975944","gln_pyr_1_4hr":"165.0078027","gln_pyr_2_4hr":"479.6797516","gln_pyr_3_4hr":"134.4699716","gluc_1_4hr":"236.2541785","gluc_2_4hr":"658.0949479","gluc_3_4hr":"343.6894984","gluc_pyr_1_4hr":"33.36235977","gluc_pyr_2_4hr":"84.4315923","gluc_pyr_3_4hr":"4.871202039","pyr_1_4hr":"309.9010696","pyr_2_4hr":"303.3575744","pyr_3_4hr":"319.0737451","ctrl_1_8hr":"138.7853907","ctrl_2_8hr":"425.0779506","ctrl_3_8hr":"194.5247159","gln_1_8hr":"43.66724368","gln_2_8hr":"127.4688971","gln_3_8hr":"54.27433381","gln_gluc_1_8hr":"48.38563101","gln_gluc_2_8hr":"269.7199672","gln_gluc_3_8hr":"98.1928323","gln_pyr_1_8hr":"59.63079527","gln_pyr_2_8hr":"197.6188806","gln_pyr_3_8hr":"141.7379592","gluc_1_8hr":"NA","gluc_2_8hr":"26.250627","gluc_3_8hr":"100.6523659","gluc_pyr_1_8hr":"119.9340693","gluc_pyr_2_8hr":"189.0579398","gluc_pyr_3_8hr":"117.2520118","pyr_1_8hr":"219.8129969","pyr_2_8hr":"322.0896738","pyr_3_8hr":"32.99250244","ctrl_1_24hr":"235.4187489","ctrl_2_24hr":"198.002329","ctrl_3_24hr":"290.7782124","gln_1_24hr":"15.07753596","gln_2_24hr":"108.1650684","gln_3_24hr":"78.12910279","gln_gluc_1_24hr":"280.0981612","gln_gluc_2_24hr":"703.726107","gln_gluc_3_24hr":"475.3416516","gln_pyr_1_24hr":"172.9073798","gln_pyr_2_24hr":"413.5406985","gln_pyr_3_24hr":"99.19101933","gluc_1_24hr":"54.66723777","gluc_2_24hr":"268.9554763","gluc_3_24hr":"162.9971458","gluc_pyr_1_24hr":"NA","gluc_pyr_2_24hr":"9.833379121","gluc_pyr_3_24hr":"NA","pyr_1_24hr":"161.3378078","pyr_2_24hr":"171.9162176","pyr_3_24hr":"308.326018"},{"Metabolite":"2-oxobutyric acid","ctrl_1_1hr":"75.43991147","ctrl_2_1hr":"97.63316588","ctrl_3_1hr":"147.0412149","gln_1_1hr":"51.75211894","gln_2_1hr":"67.20567947","gln_3_1hr":"125.9213634","gln_gluc_1_1hr":"66.70754694","gln_gluc_2_1hr":"83.53126964","gln_gluc_3_1hr":"178.9190501","gln_pyr_1_1hr":"249.9991261","gln_pyr_2_1hr":"291.5300845","gln_pyr_3_1hr":"440.403729","gluc_1_1hr":"51.32725803","gluc_2_1hr":"55.24840823","gluc_3_1hr":"112.2951925","gluc_pyr_1_1hr":"111.7168451","gluc_pyr_2_1hr":"121.5181025","gluc_pyr_3_1hr":"341.5162631","pyr_1_1hr":"104.2993886","pyr_2_1hr":"164.6220803","pyr_3_1hr":"338.2122272","ctrl_1_4hr":"74.11313322","ctrl_2_4hr":"90.08193831","ctrl_3_4hr":"174.5975525","gln_1_4hr":"56.55437126","gln_2_4hr":"71.39543013","gln_3_4hr":"125.4837968","gln_gluc_1_4hr":"73.54679242","gln_gluc_2_4hr":"96.41540217","gln_gluc_3_4hr":"154.6483183","gln_pyr_1_4hr":"73.44973795","gln_pyr_2_4hr":"87.31986302","gln_pyr_3_4hr":"120.0295424","gluc_1_4hr":"64.91998349","gluc_2_4hr":"100.7954307","gluc_3_4hr":"160.6974828","gluc_pyr_1_4hr":"64.70868162","gluc_pyr_2_4hr":"117.443096","gluc_pyr_3_4hr":"102.4070176","pyr_1_4hr":"250.3007752","pyr_2_4hr":"366.086486","pyr_3_4hr":"562.6950755","ctrl_1_8hr":"52.44174309","ctrl_2_8hr":"62.07195283","ctrl_3_8hr":"139.0317728","gln_1_8hr":"82.43082955","gln_2_8hr":"84.51425028","gln_3_8hr":"164.6355489","gln_gluc_1_8hr":"70.36331361","gln_gluc_2_8hr":"72.6589399","gln_gluc_3_8hr":"139.3183629","gln_pyr_1_8hr":"63.69159368","gln_pyr_2_8hr":"67.89705935","gln_pyr_3_8hr":"146.0312016","gluc_1_8hr":"73.70106421","gluc_2_8hr":"74.34290914","gluc_3_8hr":"173.3482374","gluc_pyr_1_8hr":"58.19807846","gluc_pyr_2_8hr":"58.83389227","gluc_pyr_3_8hr":"136.3206652","pyr_1_8hr":"57.03067474","pyr_2_8hr":"56.64399383","pyr_3_8hr":"127.0698622","ctrl_1_24hr":"293.1441713","ctrl_2_24hr":"335.5174864","ctrl_3_24hr":"812.3383168","gln_1_24hr":"51.62808919","gln_2_24hr":"58.81171109","gln_3_24hr":"90.2877406","gln_gluc_1_24hr":"345.0380494","gln_gluc_2_24hr":"375.972165","gln_gluc_3_24hr":"900.5170853","gln_pyr_1_24hr":"478.6939562","gln_pyr_2_24hr":"484.4460347","gln_pyr_3_24hr":"1144.881912","gluc_1_24hr":"83.06393089","gluc_2_24hr":"73.69913256","gluc_3_24hr":"221.2032936","gluc_pyr_1_24hr":"57.96304752","gluc_pyr_2_24hr":"91.71943078","gluc_pyr_3_24hr":"124.3298873","pyr_1_24hr":"114.5219342","pyr_2_24hr":"132.6850724","pyr_3_24hr":"154.1677221"},{"Metabolite":"4-acetamidobutanoate","ctrl_1_1hr":"NA","ctrl_2_1hr":"NA","ctrl_3_1hr":"NA","gln_1_1hr":"NA","gln_2_1hr":"NA","gln_3_1hr":"NA","gln_gluc_1_1hr":"NA","gln_gluc_2_1hr":"NA","gln_gluc_3_1hr":"1.432122586","gln_pyr_1_1hr":"NA","gln_pyr_2_1hr":"NA","gln_pyr_3_1hr":"NA","gluc_1_1hr":"NA","gluc_2_1hr":"NA","gluc_3_1hr":"NA","gluc_pyr_1_1hr":"NA","gluc_pyr_2_1hr":"NA","gluc_pyr_3_1hr":"NA","pyr_1_1hr":"NA","pyr_2_1hr":"NA","pyr_3_1hr":"NA","ctrl_1_4hr":"0.64412494","ctrl_2_4hr":"3.869681876","ctrl_3_4hr":"19.45814801","gln_1_4hr":"NA","gln_2_4hr":"NA","gln_3_4hr":"NA","gln_gluc_1_4hr":"NA","gln_gluc_2_4hr":"NA","gln_gluc_3_4hr":"NA","gln_pyr_1_4hr":"119.5429982","gln_pyr_2_4hr":"49.2600355","gln_pyr_3_4hr":"27.0624196","gluc_1_4hr":"NA","gluc_2_4hr":"10.40353559","gluc_3_4hr":"24.64126611","gluc_pyr_1_4hr":"NA","gluc_pyr_2_4hr":"NA","gluc_pyr_3_4hr":"18.59575025","pyr_1_4hr":"78.71340011","pyr_2_4hr":"76.37454848","pyr_3_4hr":"57.84642876","ctrl_1_8hr":"NA","ctrl_2_8hr":"NA","ctrl_3_8hr":"NA","gln_1_8hr":"NA","gln_2_8hr":"NA","gln_3_8hr":"NA","gln_gluc_1_8hr":"NA","gln_gluc_2_8hr":"NA","gln_gluc_3_8hr":"NA","gln_pyr_1_8hr":"58.35179666","gln_pyr_2_8hr":"47.4795804","gln_pyr_3_8hr":"49.69302455","gluc_1_8hr":"53.76374521","gluc_2_8hr":"33.71358766","gluc_3_8hr":"53.70577484","gluc_pyr_1_8hr":"NA","gluc_pyr_2_8hr":"NA","gluc_pyr_3_8hr":"NA","pyr_1_8hr":"NA","pyr_2_8hr":"NA","pyr_3_8hr":"NA","ctrl_1_24hr":"58.69645943","ctrl_2_24hr":"60.33284638","ctrl_3_24hr":"64.82220156","gln_1_24hr":"NA","gln_2_24hr":"NA","gln_3_24hr":"16.0465842","gln_gluc_1_24hr":"NA","gln_gluc_2_24hr":"NA","gln_gluc_3_24hr":"NA","gln_pyr_1_24hr":"81.44367156","gln_pyr_2_24hr":"85.24458921","gln_pyr_3_24hr":"72.18645272","gluc_1_24hr":"NA","gluc_2_24hr":"NA","gluc_3_24hr":"NA","gluc_pyr_1_24hr":"NA","gluc_pyr_2_24hr":"NA","gluc_pyr_3_24hr":"NA","pyr_1_24hr":"184.011883","pyr_2_24hr":"122.4297095","pyr_3_24hr":"64.50436527"},{"Metabolite":"4-imidazoleacetate","ctrl_1_1hr":"148.7134836","ctrl_2_1hr":"94.94564401","ctrl_3_1hr":"62.39682964","gln_1_1hr":"38.24476375","gln_2_1hr":"31.40204741","gln_3_1hr":"39.42369544","gln_gluc_1_1hr":"1369.467154","gln_gluc_2_1hr":"343.4115375","gln_gluc_3_1hr":"1550.412396","gln_pyr_1_1hr":"142.3741567","gln_pyr_2_1hr":"88.7187539","gln_pyr_3_1hr":"100.0233445","gluc_1_1hr":"252.6706292","gluc_2_1hr":"249.932293","gluc_3_1hr":"96.47963546","gluc_pyr_1_1hr":"34.92238523","gluc_pyr_2_1hr":"131.6923955","gluc_pyr_3_1hr":"51.38815193","pyr_1_1hr":"36.98479401","pyr_2_1hr":"27.71966762","pyr_3_1hr":"68.02760923","ctrl_1_4hr":"33.6095079","ctrl_2_4hr":"25.1741149","ctrl_3_4hr":"27.17410242","gln_1_4hr":"149.4327327","gln_2_4hr":"79.2053114","gln_3_4hr":"78.93877499","gln_gluc_1_4hr":"327.3477893","gln_gluc_2_4hr":"123.2787034","gln_gluc_3_4hr":"185.8727866","gln_pyr_1_4hr":"119.5699581","gln_pyr_2_4hr":"117.7188377","gln_pyr_3_4hr":"NA","gluc_1_4hr":"722.5671934","gluc_2_4hr":"237.2583704","gluc_3_4hr":"1051.427999","gluc_pyr_1_4hr":"185.7918992","gluc_pyr_2_4hr":"7.573527048","gluc_pyr_3_4hr":"28.85408772","pyr_1_4hr":"116.711863","pyr_2_4hr":"94.28432309","pyr_3_4hr":"99.45789446","ctrl_1_8hr":"NA","ctrl_2_8hr":"55.06866065","ctrl_3_8hr":"NA","gln_1_8hr":"59.56144536","gln_2_8hr":"14.30657329","gln_3_8hr":"2.436579032","gln_gluc_1_8hr":"208.3904193","gln_gluc_2_8hr":"115.4608622","gln_gluc_3_8hr":"43.53785081","gln_pyr_1_8hr":"156.282217","gln_pyr_2_8hr":"77.95078543","gln_pyr_3_8hr":"75.38134115","gluc_1_8hr":"195.1619387","gluc_2_8hr":"136.3602107","gluc_3_8hr":"432.7334073","gluc_pyr_1_8hr":"76.06703649","gluc_pyr_2_8hr":"10.63658325","gluc_pyr_3_8hr":"34.74763199","pyr_1_8hr":"57.32097976","pyr_2_8hr":"4.439743847","pyr_3_8hr":"4.34896667","ctrl_1_24hr":"68.79434298","ctrl_2_24hr":"72.09439407","ctrl_3_24hr":"37.05476963","gln_1_24hr":"226.2504678","gln_2_24hr":"101.4036235","gln_3_24hr":"94.95903608","gln_gluc_1_24hr":"82.93038972","gln_gluc_2_24hr":"15.19307349","gln_gluc_3_24hr":"56.17274103","gln_pyr_1_24hr":"78.97734349","gln_pyr_2_24hr":"37.48935206","gln_pyr_3_24hr":"16.18243029","gluc_1_24hr":"6163.476863","gluc_2_24hr":"947.9187664","gluc_3_24hr":"9295.049252","gluc_pyr_1_24hr":"74.1101678","gluc_pyr_2_24hr":"23.08240868","gluc_pyr_3_24hr":"46.16049834","pyr_1_24hr":"229.7490652","pyr_2_24hr":"94.62821517","pyr_3_24hr":"58.06059528"},{"Metabolite":"adipic acid","ctrl_1_1hr":"40.85726057","ctrl_2_1hr":"66.2492806","ctrl_3_1hr":"46.6225524","gln_1_1hr":"562.3027013","gln_2_1hr":"314.9078375","gln_3_1hr":"415.019492","gln_gluc_1_1hr":"40.947582","gln_gluc_2_1hr":"48.05835922","gln_gluc_3_1hr":"18.07928529","gln_pyr_1_1hr":"146.9597498","gln_pyr_2_1hr":"168.9327873","gln_pyr_3_1hr":"223.9021999","gluc_1_1hr":"68.87492536","gluc_2_1hr":"56.23862667","gluc_3_1hr":"60.46452058","gluc_pyr_1_1hr":"71.39074897","gluc_pyr_2_1hr":"60.87499202","gluc_pyr_3_1hr":"49.53044065","pyr_1_1hr":"120.4837907","pyr_2_1hr":"80.99919238","pyr_3_1hr":"83.58483064","ctrl_1_4hr":"138.4323059","ctrl_2_4hr":"59.27442116","ctrl_3_4hr":"24.26167721","gln_1_4hr":"49.18597036","gln_2_4hr":"52.81705626","gln_3_4hr":"27.75626971","gln_gluc_1_4hr":"52.94016279","gln_gluc_2_4hr":"45.28957691","gln_gluc_3_4hr":"30.40540881","gln_pyr_1_4hr":"38.58336323","gln_pyr_2_4hr":"42.88888516","gln_pyr_3_4hr":"25.94212608","gluc_1_4hr":"60.18403179","gluc_2_4hr":"80.07674311","gluc_3_4hr":"158.3213423","gluc_pyr_1_4hr":"315.7350024","gluc_pyr_2_4hr":"121.7310259","gluc_pyr_3_4hr":"163.0424491","pyr_1_4hr":"91.11740175","pyr_2_4hr":"63.46718869","pyr_3_4hr":"86.34971272","ctrl_1_8hr":"32.5102986","ctrl_2_8hr":"44.46108834","ctrl_3_8hr":"53.71251721","gln_1_8hr":"105.9091412","gln_2_8hr":"61.84304394","gln_3_8hr":"36.30712353","gln_gluc_1_8hr":"49.35730051","gln_gluc_2_8hr":"60.40770543","gln_gluc_3_8hr":"26.84460364","gln_pyr_1_8hr":"55.31417814","gln_pyr_2_8hr":"50.93569303","gln_pyr_3_8hr":"59.98138901","gluc_1_8hr":"51.74899572","gluc_2_8hr":"53.56845952","gluc_3_8hr":"47.98968958","gluc_pyr_1_8hr":"57.29761272","gluc_pyr_2_8hr":"51.03703898","gluc_pyr_3_8hr":"22.55009417","pyr_1_8hr":"32.42635477","pyr_2_8hr":"39.0304293","pyr_3_8hr":"45.07791549","ctrl_1_24hr":"70.93932017","ctrl_2_24hr":"60.37712679","ctrl_3_24hr":"56.00765173","gln_1_24hr":"86.07923498","gln_2_24hr":"72.29806639","gln_3_24hr":"85.14428276","gln_gluc_1_24hr":"126.9012886","gln_gluc_2_24hr":"119.2611266","gln_gluc_3_24hr":"173.9976459","gln_pyr_1_24hr":"122.6737824","gln_pyr_2_24hr":"84.20645565","gln_pyr_3_24hr":"118.3025165","gluc_1_24hr":"125.4319392","gluc_2_24hr":"123.6880417","gluc_3_24hr":"154.5603686","gluc_pyr_1_24hr":"152.0444884","gluc_pyr_2_24hr":"124.9754318","gluc_pyr_3_24hr":"139.8518384","pyr_1_24hr":"41.48705723","pyr_2_24hr":"46.80726589","pyr_3_24hr":"43.43694792"},{"Metabolite":"akg","ctrl_1_1hr":"4976.440436","ctrl_2_1hr":"5031.109807","ctrl_3_1hr":"988.2467018","gln_1_1hr":"1866.849422","gln_2_1hr":"1734.77525","gln_3_1hr":"NA","gln_gluc_1_1hr":"1817.821936","gln_gluc_2_1hr":"2661.437527","gln_gluc_3_1hr":"6495.95925","gln_pyr_1_1hr":"1132.527652","gln_pyr_2_1hr":"637.4515001","gln_pyr_3_1hr":"NA","gluc_1_1hr":"1229.685411","gluc_2_1hr":"980.5936257","gluc_3_1hr":"NA","gluc_pyr_1_1hr":"2615.950831","gluc_pyr_2_1hr":"2392.405586","gluc_pyr_3_1hr":"14174.90115","pyr_1_1hr":"5257.089748","pyr_2_1hr":"5136.584113","pyr_3_1hr":"20602.02706","ctrl_1_4hr":"993.4156229","ctrl_2_4hr":"590.3076975","ctrl_3_4hr":"NA","gln_1_4hr":"1440.970262","gln_2_4hr":"1171.944103","gln_3_4hr":"NA","gln_gluc_1_4hr":"5303.748671","gln_gluc_2_4hr":"5316.029041","gln_gluc_3_4hr":"10994.34308","gln_pyr_1_4hr":"1429.269237","gln_pyr_2_4hr":"1074.999986","gln_pyr_3_4hr":"NA","gluc_1_4hr":"5503.98263","gluc_2_4hr":"6242.754177","gluc_3_4hr":"21014.43929","gluc_pyr_1_4hr":"1527.787843","gluc_pyr_2_4hr":"1086.184225","gluc_pyr_3_4hr":"NA","pyr_1_4hr":"1252.29204","pyr_2_4hr":"936.7031623","pyr_3_4hr":"NA","ctrl_1_8hr":"3339.3357","ctrl_2_8hr":"3593.99089","ctrl_3_8hr":"9016.988889","gln_1_8hr":"2115.897442","gln_2_8hr":"2371.450659","gln_3_8hr":"NA","gln_gluc_1_8hr":"4644.733976","gln_gluc_2_8hr":"7041.842232","gln_gluc_3_8hr":"26332.20459","gln_pyr_1_8hr":"2134.290099","gln_pyr_2_8hr":"1616.340413","gln_pyr_3_8hr":"NA","gluc_1_8hr":"6304.851944","gluc_2_8hr":"9781.209746","gluc_3_8hr":"37122.03625","gluc_pyr_1_8hr":"6669.482463","gluc_pyr_2_8hr":"8866.227948","gluc_pyr_3_8hr":"26659.63594","pyr_1_8hr":"1236.606851","pyr_2_8hr":"659.3552035","pyr_3_8hr":"NA","ctrl_1_24hr":"3790.436653","ctrl_2_24hr":"4744.463657","ctrl_3_24hr":"3965.434291","gln_1_24hr":"3594.960004","gln_2_24hr":"3772.941598","gln_3_24hr":"1550.5281","gln_gluc_1_24hr":"1416.062255","gln_gluc_2_24hr":"735.339156","gln_gluc_3_24hr":"NA","gln_pyr_1_24hr":"1404.543469","gln_pyr_2_24hr":"1695.974922","gln_pyr_3_24hr":"NA","gluc_1_24hr":"4849.431897","gluc_2_24hr":"5552.188219","gluc_3_24hr":"6624.443449","gluc_pyr_1_24hr":"1114.339796","gluc_pyr_2_24hr":"934.3076406","gluc_pyr_3_24hr":"NA","pyr_1_24hr":"1281.322597","pyr_2_24hr":"747.1767264","pyr_3_24hr":"NA"},{"Metabolite":"azelate","ctrl_1_1hr":"92.85879514","ctrl_2_1hr":"42.78664713","ctrl_3_1hr":"206.2358882","gln_1_1hr":"97.87150991","gln_2_1hr":"127.326012","gln_3_1hr":"234.9355964","gln_gluc_1_1hr":"2093.536379","gln_gluc_2_1hr":"4631.774086","gln_gluc_3_1hr":"4763.913454","gln_pyr_1_1hr":"102.5564092","gln_pyr_2_1hr":"134.7707555","gln_pyr_3_1hr":"267.073094","gluc_1_1hr":"187.4089983","gluc_2_1hr":"390.9160257","gluc_3_1hr":"430.1443196","gluc_pyr_1_1hr":"97.27146135","gluc_pyr_2_1hr":"64.43178976","gluc_pyr_3_1hr":"221.6284484","pyr_1_1hr":"96.37701933","pyr_2_1hr":"48.2816919","pyr_3_1hr":"217.5597996","ctrl_1_4hr":"76.08331686","ctrl_2_4hr":"70.00480115","ctrl_3_4hr":"219.9667686","gln_1_4hr":"76.87639604","gln_2_4hr":"NA","gln_3_4hr":"165.6556652","gln_gluc_1_4hr":"97.13596657","gln_gluc_2_4hr":"58.27393044","gln_gluc_3_4hr":"215.0913756","gln_pyr_1_4hr":"295.6377515","gln_pyr_2_4hr":"1677.329348","gln_pyr_3_4hr":"559.3445675","gluc_1_4hr":"124.2828055","gluc_2_4hr":"394.8668711","gluc_3_4hr":"251.1552842","gluc_pyr_1_4hr":"129.9488992","gluc_pyr_2_4hr":"144.3915942","gluc_pyr_3_4hr":"268.0239261","pyr_1_4hr":"148.4677162","pyr_2_4hr":"229.6021392","pyr_3_4hr":"322.8023645","ctrl_1_8hr":"98.41844113","ctrl_2_8hr":"75.54958552","ctrl_3_8hr":"222.5691196","gln_1_8hr":"96.64351782","gln_2_8hr":"36.28354879","gln_3_8hr":"217.1080466","gln_gluc_1_8hr":"98.65346504","gln_gluc_2_8hr":"79.25069521","gln_gluc_3_8hr":"218.3944537","gln_pyr_1_8hr":"97.12433773","gln_pyr_2_8hr":"55.44558189","gln_pyr_3_8hr":"222.7003641","gluc_1_8hr":"94.16226247","gluc_2_8hr":"64.33919997","gluc_3_8hr":"200.8024995","gluc_pyr_1_8hr":"97.54480601","gluc_pyr_2_8hr":"34.78777796","gluc_pyr_3_8hr":"218.204822","pyr_1_8hr":"94.32633906","pyr_2_8hr":"14.83921744","pyr_3_8hr":"215.4853442","ctrl_1_24hr":"136.9666567","ctrl_2_24hr":"NA","ctrl_3_24hr":"NA","gln_1_24hr":"458.0703788","gln_2_24hr":"1105.468342","gln_3_24hr":"1002.615716","gln_gluc_1_24hr":"101.7311854","gln_gluc_2_24hr":"50.94159697","gln_gluc_3_24hr":"207.4133488","gln_pyr_1_24hr":"1891.136507","gln_pyr_2_24hr":"4613.557876","gln_pyr_3_24hr":"4783.690523","gluc_1_24hr":"131.9152839","gluc_2_24hr":"111.0020976","gluc_3_24hr":"288.193867","gluc_pyr_1_24hr":"101.0926355","gluc_pyr_2_24hr":"82.26166453","gluc_pyr_3_24hr":"228.5751729","pyr_1_24hr":"100.5325869","pyr_2_24hr":"55.44878476","pyr_3_24hr":"212.6925599"},{"Metabolite":"benzoate","ctrl_1_1hr":"18358.88153","ctrl_2_1hr":"8222.060609","ctrl_3_1hr":"3813.522149","gln_1_1hr":"19645.35927","gln_2_1hr":"16157.99041","gln_3_1hr":"5172.022639","gln_gluc_1_1hr":"19796.82763","gln_gluc_2_1hr":"15670.72387","gln_gluc_3_1hr":"5858.420163","gln_pyr_1_1hr":"10777.97017","gln_pyr_2_1hr":"9492.590344","gln_pyr_3_1hr":"4190.426719","gluc_1_1hr":"22952.04365","gluc_2_1hr":"17595.49698","gluc_3_1hr":"6363.564446","gluc_pyr_1_1hr":"19355.24205","gluc_pyr_2_1hr":"15859.16482","gluc_pyr_3_1hr":"5913.979738","pyr_1_1hr":"17207.78431","pyr_2_1hr":"15506.83823","pyr_3_1hr":"6851.871135","ctrl_1_4hr":"21095.00257","ctrl_2_4hr":"15854.55343","ctrl_3_4hr":"6905.535808","gln_1_4hr":"13520.51069","gln_2_4hr":"15813.47046","gln_3_4hr":"6945.952372","gln_gluc_1_4hr":"3776.323847","gln_gluc_2_4hr":"6438.957682","gln_gluc_3_4hr":"7926.02315","gln_pyr_1_4hr":"2867.041329","gln_pyr_2_4hr":"7028.435293","gln_pyr_3_4hr":"4294.374528","gluc_1_4hr":"11648.13181","gluc_2_4hr":"14098.78926","gluc_3_4hr":"6517.17796","gluc_pyr_1_4hr":"22541.12451","gluc_pyr_2_4hr":"17542.13773","gluc_pyr_3_4hr":"6350.14815","pyr_1_4hr":"NA","pyr_2_4hr":"NA","pyr_3_4hr":"NA","ctrl_1_8hr":"33069.2937","ctrl_2_8hr":"16536.86185","ctrl_3_8hr":"6785.025515","gln_1_8hr":"32444.73032","gln_2_8hr":"17528.76904","gln_3_8hr":"8013.428871","gln_gluc_1_8hr":"17658.02772","gln_gluc_2_8hr":"14632.95841","gln_gluc_3_8hr":"5853.451492","gln_pyr_1_8hr":"25067.5857","gln_pyr_2_8hr":"15986.74198","gln_pyr_3_8hr":"6531.130945","gluc_1_8hr":"16642.75696","gluc_2_8hr":"11960.4638","gluc_3_8hr":"5805.133681","gluc_pyr_1_8hr":"12540.58304","gluc_pyr_2_8hr":"6979.63993","gluc_pyr_3_8hr":"2947.839271","pyr_1_8hr":"15190.17034","pyr_2_8hr":"14319.9592","pyr_3_8hr":"6638.543419","ctrl_1_24hr":"26517.81463","ctrl_2_24hr":"15107.87547","ctrl_3_24hr":"5223.93515","gln_1_24hr":"25895.16174","gln_2_24hr":"18600.11116","gln_3_24hr":"7112.685535","gln_gluc_1_24hr":"18100.95197","gln_gluc_2_24hr":"15277.72816","gln_gluc_3_24hr":"6616.935056","gln_pyr_1_24hr":"NA","gln_pyr_2_24hr":"2574.862404","gln_pyr_3_24hr":"2337.400241","gluc_1_24hr":"25996.34556","gluc_2_24hr":"17445.9768","gluc_3_24hr":"5133.167273","gluc_pyr_1_24hr":"12221.96951","gluc_pyr_2_24hr":"6346.591862","gluc_pyr_3_24hr":"2741.408562","pyr_1_24hr":"1070.355744","pyr_2_24hr":"9558.655066","pyr_3_24hr":"4376.15542"},{"Metabolite":"butyric acid","ctrl_1_1hr":"80.32690482","ctrl_2_1hr":"182.5020645","ctrl_3_1hr":"118.4064833","gln_1_1hr":"26.36099387","gln_2_1hr":"NA","gln_3_1hr":"22.33731342","gln_gluc_1_1hr":"10.95493058","gln_gluc_2_1hr":"NA","gln_gluc_3_1hr":"125.1404731","gln_pyr_1_1hr":"NA","gln_pyr_2_1hr":"NA","gln_pyr_3_1hr":"11.09399888","gluc_1_1hr":"6.834597846","gluc_2_1hr":"55.34228807","gluc_3_1hr":"67.60652158","gluc_pyr_1_1hr":"7.204652714","gluc_pyr_2_1hr":"NA","gluc_pyr_3_1hr":"72.35000196","pyr_1_1hr":"NA","pyr_2_1hr":"NA","pyr_3_1hr":"25.43965942","ctrl_1_4hr":"NA","ctrl_2_4hr":"NA","ctrl_3_4hr":"41.29050113","gln_1_4hr":"NA","gln_2_4hr":"46.43868551","gln_3_4hr":"34.10382665","gln_gluc_1_4hr":"NA","gln_gluc_2_4hr":"66.1056706","gln_gluc_3_4hr":"80.9743593","gln_pyr_1_4hr":"NA","gln_pyr_2_4hr":"66.43930543","gln_pyr_3_4hr":"31.83653543","gluc_1_4hr":"6.589781895","gluc_2_4hr":"22.8352618","gluc_3_4hr":"94.76590849","gluc_pyr_1_4hr":"27.62245212","gluc_pyr_2_4hr":"NA","gluc_pyr_3_4hr":"69.94298807","pyr_1_4hr":"38.03836103","pyr_2_4hr":"132.9562705","pyr_3_4hr":"169.1065877","ctrl_1_8hr":"NA","ctrl_2_8hr":"NA","ctrl_3_8hr":"10.18104858","gln_1_8hr":"11.20584028","gln_2_8hr":"192.3604167","gln_3_8hr":"77.24362988","gln_gluc_1_8hr":"12.50765589","gln_gluc_2_8hr":"344.2337777","gln_gluc_3_8hr":"20.67848877","gln_pyr_1_8hr":"67.1062491","gln_pyr_2_8hr":"14.69871031","gln_pyr_3_8hr":"122.0083443","gluc_1_8hr":"NA","gluc_2_8hr":"9.857356678","gluc_3_8hr":"44.17320943","gluc_pyr_1_8hr":"NA","gluc_pyr_2_8hr":"NA","gluc_pyr_3_8hr":"19.69237719","pyr_1_8hr":"NA","pyr_2_8hr":"97.09634841","pyr_3_8hr":"31.43935995","ctrl_1_24hr":"109.0409574","ctrl_2_24hr":"44.11050906","ctrl_3_24hr":"154.0552811","gln_1_24hr":"13.14417103","gln_2_24hr":"140.0848681","gln_3_24hr":"32.86410131","gln_gluc_1_24hr":"57.71821012","gln_gluc_2_24hr":"113.6476325","gln_gluc_3_24hr":"107.4025888","gln_pyr_1_24hr":"93.23862827","gln_pyr_2_24hr":"168.5685685","gln_pyr_3_24hr":"100.5288846","gluc_1_24hr":"NA","gluc_2_24hr":"61.33978287","gluc_3_24hr":"36.73366638","gluc_pyr_1_24hr":"33.10613439","gluc_pyr_2_24hr":"8.163299608","gluc_pyr_3_24hr":"54.32653044","pyr_1_24hr":"11.43531912","pyr_2_24hr":"56.10891108","pyr_3_24hr":"126.3627864"},{"Metabolite":"fumarate","ctrl_1_1hr":"162.9088833","ctrl_2_1hr":"124.6069076","ctrl_3_1hr":"89.29719996","gln_1_1hr":"146.1825026","gln_2_1hr":"163.9754208","gln_3_1hr":"163.3742451","gln_gluc_1_1hr":"47.49625612","gln_gluc_2_1hr":"20.97598319","gln_gluc_3_1hr":"NA","gln_pyr_1_1hr":"59.88971819","gln_pyr_2_1hr":"25.13479245","gln_pyr_3_1hr":"NA","gluc_1_1hr":"299.9919497","gluc_2_1hr":"178.8112363","gluc_3_1hr":"238.5544904","gluc_pyr_1_1hr":"42.97270977","gluc_pyr_2_1hr":"9.34428675","gluc_pyr_3_1hr":"NA","pyr_1_1hr":"261.8926133","pyr_2_1hr":"289.2743445","pyr_3_1hr":"289.2993986","ctrl_1_4hr":"153.8145361","ctrl_2_4hr":"148.0651525","ctrl_3_4hr":"170.6634585","gln_1_4hr":"163.5443785","gln_2_4hr":"65.3826388","gln_3_4hr":"104.126992","gln_gluc_1_4hr":"480.0534487","gln_gluc_2_4hr":"604.2813359","gln_gluc_3_4hr":"719.7586004","gln_pyr_1_4hr":"153.9298805","gln_pyr_2_4hr":"153.0074253","gln_pyr_3_4hr":"203.4360973","gluc_1_4hr":"35.73064815","gluc_2_4hr":"6.7878031","gluc_3_4hr":"NA","gluc_pyr_1_4hr":"48.76723729","gluc_pyr_2_4hr":"15.47173963","gluc_pyr_3_4hr":"NA","pyr_1_4hr":"83.83460455","pyr_2_4hr":"69.6258812","pyr_3_4hr":"NA","ctrl_1_8hr":"161.3684701","ctrl_2_8hr":"135.2565908","ctrl_3_8hr":"284.1559481","gln_1_8hr":"159.5160695","gln_2_8hr":"166.5541234","gln_3_8hr":"153.3223724","gln_gluc_1_8hr":"544.5234349","gln_gluc_2_8hr":"642.2186199","gln_gluc_3_8hr":"1156.250265","gln_pyr_1_8hr":"121.7463593","gln_pyr_2_8hr":"90.20091516","gln_pyr_3_8hr":"63.10481144","gluc_1_8hr":"92.50948976","gluc_2_8hr":"67.65158786","gluc_3_8hr":"NA","gluc_pyr_1_8hr":"54.80159153","gluc_pyr_2_8hr":"27.57445905","gluc_pyr_3_8hr":"NA","pyr_1_8hr":"219.8433344","pyr_2_8hr":"238.4290516","pyr_3_8hr":"315.109041","ctrl_1_24hr":"92.6807132","ctrl_2_24hr":"84.73339743","ctrl_3_24hr":"NA","gln_1_24hr":"304.2909943","gln_2_24hr":"439.1508829","gln_3_24hr":"800.3450988","gln_gluc_1_24hr":"36.5463054","gln_gluc_2_24hr":"NA","gln_gluc_3_24hr":"NA","gln_pyr_1_24hr":"472.1733094","gln_pyr_2_24hr":"522.4385083","gln_pyr_3_24hr":"655.7226773","gluc_1_24hr":"49.72252926","gluc_2_24hr":"35.41465263","gluc_3_24hr":"NA","gluc_pyr_1_24hr":"36.20046067","gluc_pyr_2_24hr":"NA","gluc_pyr_3_24hr":"NA","pyr_1_24hr":"90.13401308","pyr_2_24hr":"71.16735399","pyr_3_24hr":"NA"},{"Metabolite":"glutarate","ctrl_1_1hr":"378.205127","ctrl_2_1hr":"717.5209514","ctrl_3_1hr":"336.3563392","gln_1_1hr":"132.1164454","gln_2_1hr":"142.3416309","gln_3_1hr":"184.9591649","gln_gluc_1_1hr":"51.14245029","gln_gluc_2_1hr":"97.40439374","gln_gluc_3_1hr":"104.0464168","gln_pyr_1_1hr":"630.8972691","gln_pyr_2_1hr":"980.9127857","gln_pyr_3_1hr":"633.1264476","gluc_1_1hr":"150.0796144","gluc_2_1hr":"181.2702453","gluc_3_1hr":"151.9103864","gluc_pyr_1_1hr":"150.9945705","gluc_pyr_2_1hr":"163.8277629","gluc_pyr_3_1hr":"142.0080658","pyr_1_1hr":"570.3300239","pyr_2_1hr":"775.0354294","pyr_3_1hr":"526.7054503","ctrl_1_4hr":"317.3620693","ctrl_2_4hr":"395.5446903","ctrl_3_4hr":"288.0674888","gln_1_4hr":"430.4560014","gln_2_4hr":"647.3268949","gln_3_4hr":"379.1316541","gln_gluc_1_4hr":"225.0428734","gln_gluc_2_4hr":"454.3902598","gln_gluc_3_4hr":"209.5837442","gln_pyr_1_4hr":"69.33824262","gln_pyr_2_4hr":"76.71449522","gln_pyr_3_4hr":"107.8286345","gluc_1_4hr":"255.4328638","gluc_2_4hr":"402.2410859","gluc_3_4hr":"257.4625282","gluc_pyr_1_4hr":"357.6438138","gluc_pyr_2_4hr":"425.6042883","gluc_pyr_3_4hr":"347.1006312","pyr_1_4hr":"236.693238","pyr_2_4hr":"275.582533","pyr_3_4hr":"229.3033506","ctrl_1_8hr":"147.6397483","ctrl_2_8hr":"291.6388429","ctrl_3_8hr":"149.083884","gln_1_8hr":"NA","gln_2_8hr":"NA","gln_3_8hr":"12.22445626","gln_gluc_1_8hr":"96.62514153","gln_gluc_2_8hr":"132.500093","gln_gluc_3_8hr":"68.01533371","gln_pyr_1_8hr":"NA","gln_pyr_2_8hr":"NA","gln_pyr_3_8hr":"NA","gluc_1_8hr":"21.21606175","gluc_2_8hr":"27.18563515","gluc_3_8hr":"71.16587786","gluc_pyr_1_8hr":"46.70121182","gluc_pyr_2_8hr":"40.80063501","gluc_pyr_3_8hr":"39.54983386","pyr_1_8hr":"186.7164613","pyr_2_8hr":"230.6761089","pyr_3_8hr":"192.9959891","ctrl_1_24hr":"NA","ctrl_2_24hr":"NA","ctrl_3_24hr":"NA","gln_1_24hr":"371.5090336","gln_2_24hr":"522.8608325","gln_3_24hr":"307.5609441","gln_gluc_1_24hr":"268.0214017","gln_gluc_2_24hr":"464.5977531","gln_gluc_3_24hr":"288.387442","gln_pyr_1_24hr":"312.3698697","gln_pyr_2_24hr":"453.2589184","gln_pyr_3_24hr":"248.0675562","gluc_1_24hr":"43.91205441","gluc_2_24hr":"NA","gluc_3_24hr":"80.58806098","gluc_pyr_1_24hr":"291.4587173","gluc_pyr_2_24hr":"429.273422","gluc_pyr_3_24hr":"338.7824757","pyr_1_24hr":"135.0060241","pyr_2_24hr":"159.9599568","pyr_3_24hr":"122.2022616"},{"Metabolite":"hexanoate","ctrl_1_1hr":"51.45161621","ctrl_2_1hr":"NA","ctrl_3_1hr":"1073.311567","gln_1_1hr":"291.1163111","gln_2_1hr":"102.6704814","gln_3_1hr":"254.8600865","gln_gluc_1_1hr":"NA","gln_gluc_2_1hr":"NA","gln_gluc_3_1hr":"872.766045","gln_pyr_1_1hr":"NA","gln_pyr_2_1hr":"NA","gln_pyr_3_1hr":"253.6666807","gluc_1_1hr":"NA","gluc_2_1hr":"NA","gluc_3_1hr":"618.8065135","gluc_pyr_1_1hr":"NA","gluc_pyr_2_1hr":"64.11942042","gluc_pyr_3_1hr":"407.2856246","pyr_1_1hr":"787.5805168","pyr_2_1hr":"300.8236253","pyr_3_1hr":"NA","ctrl_1_4hr":"NA","ctrl_2_4hr":"NA","ctrl_3_4hr":"313.0044648","gln_1_4hr":"56.38353093","gln_2_4hr":"62.57674539","gln_3_4hr":"862.3520291","gln_gluc_1_4hr":"1203.788943","gln_gluc_2_4hr":"578.4558747","gln_gluc_3_4hr":"66.70630951","gln_pyr_1_4hr":"188.7195004","gln_pyr_2_4hr":"83.01803589","gln_pyr_3_4hr":"101.8992338","gluc_1_4hr":"295.8907566","gluc_2_4hr":"126.3857218","gluc_3_4hr":"44.29204946","gluc_pyr_1_4hr":"NA","gluc_pyr_2_4hr":"NA","gluc_pyr_3_4hr":"198.6674057","pyr_1_4hr":"120.6306941","pyr_2_4hr":"NA","pyr_3_4hr":"258.3591373","ctrl_1_8hr":"NA","ctrl_2_8hr":"105.7532766","ctrl_3_8hr":"123.9325787","gln_1_8hr":"NA","gln_2_8hr":"NA","gln_3_8hr":"130.7920922","gln_gluc_1_8hr":"163.9128034","gln_gluc_2_8hr":"89.87748907","gln_gluc_3_8hr":"413.0643717","gln_pyr_1_8hr":"121.2639105","gln_pyr_2_8hr":"134.3585952","gln_pyr_3_8hr":"54.40631439","gluc_1_8hr":"NA","gluc_2_8hr":"NA","gluc_3_8hr":"951.1333767","gluc_pyr_1_8hr":"NA","gluc_pyr_2_8hr":"66.17591017","gluc_pyr_3_8hr":"1489.786947","pyr_1_8hr":"207.4801605","pyr_2_8hr":"20.34855733","pyr_3_8hr":"199.7024945","ctrl_1_24hr":"120.3799697","ctrl_2_24hr":"191.8300219","ctrl_3_24hr":"NA","gln_1_24hr":"NA","gln_2_24hr":"NA","gln_3_24hr":"133.6739787","gln_gluc_1_24hr":"NA","gln_gluc_2_24hr":"NA","gln_gluc_3_24hr":"378.256487","gln_pyr_1_24hr":"NA","gln_pyr_2_24hr":"NA","gln_pyr_3_24hr":"250.0150722","gluc_1_24hr":"6246.134066","gluc_2_24hr":"2940.058109","gluc_3_24hr":"NA","gluc_pyr_1_24hr":"NA","gluc_pyr_2_24hr":"110.9330709","gluc_pyr_3_24hr":"296.9114892","pyr_1_24hr":"NA","pyr_2_24hr":"NA","pyr_3_24hr":"463.7166428"},{"Metabolite":"lactate","ctrl_1_1hr":"83.50395664","ctrl_2_1hr":"64597.59519","ctrl_3_1hr":"1486421.031","gln_1_1hr":"NA","gln_2_1hr":"29539.48502","gln_3_1hr":"746994.3304","gln_gluc_1_1hr":"7657.521248","gln_gluc_2_1hr":"190111.7853","gln_gluc_3_1hr":"1992142.75","gln_pyr_1_1hr":"NA","gln_pyr_2_1hr":"NA","gln_pyr_3_1hr":"NA","gluc_1_1hr":"2376.26016","gluc_2_1hr":"114431.1276","gluc_3_1hr":"1077011.08","gluc_pyr_1_1hr":"1905.978352","gluc_pyr_2_1hr":"118984.4661","gluc_pyr_3_1hr":"1539905.733","pyr_1_1hr":"7871.104331","pyr_2_1hr":"184151.6464","pyr_3_1hr":"NA","ctrl_1_4hr":"3207.528696","ctrl_2_4hr":"116704.9215","ctrl_3_4hr":"1597811.43","gln_1_4hr":"4759.281033","gln_2_4hr":"161913.1137","gln_3_4hr":"1493686.021","gln_gluc_1_4hr":"9466.948717","gln_gluc_2_4hr":"241252.5808","gln_gluc_3_4hr":"1751321.46","gln_pyr_1_4hr":"NA","gln_pyr_2_4hr":"28788.14664","gln_pyr_3_4hr":"138736.9043","gluc_1_4hr":"1705.782949","gluc_2_4hr":"99354.50943","gluc_3_4hr":"1105623.541","gluc_pyr_1_4hr":"4577.025747","gluc_pyr_2_4hr":"162170.2988","gluc_pyr_3_4hr":"1639238.478","pyr_1_4hr":"8507.059433","pyr_2_4hr":"250903.0389","pyr_3_4hr":"2901617.83","ctrl_1_8hr":"NA","ctrl_2_8hr":"NA","ctrl_3_8hr":"NA","gln_1_8hr":"NA","gln_2_8hr":"NA","gln_3_8hr":"NA","gln_gluc_1_8hr":"NA","gln_gluc_2_8hr":"NA","gln_gluc_3_8hr":"75454.98234","gln_pyr_1_8hr":"NA","gln_pyr_2_8hr":"NA","gln_pyr_3_8hr":"NA","gluc_1_8hr":"6214.344304","gluc_2_8hr":"181800.2144","gluc_3_8hr":"2112327.607","gluc_pyr_1_8hr":"NA","gluc_pyr_2_8hr":"NA","gluc_pyr_3_8hr":"NA","pyr_1_8hr":"NA","pyr_2_8hr":"NA","pyr_3_8hr":"NA","ctrl_1_24hr":"1607.872516","ctrl_2_24hr":"36345.53243","ctrl_3_24hr":"536337.4374","gln_1_24hr":"45049.0602","gln_2_24hr":"724392.3268","gln_3_24hr":"3272832.243","gln_gluc_1_24hr":"10386.53667","gln_gluc_2_24hr":"266211.6613","gln_gluc_3_24hr":"2633227.14","gln_pyr_1_24hr":"3961.421993","gln_pyr_2_24hr":"120532.0196","gln_pyr_3_24hr":"7801.642763","gluc_1_24hr":"NA","gluc_2_24hr":"NA","gluc_3_24hr":"NA","gluc_pyr_1_24hr":"6423.551286","gluc_pyr_2_24hr":"173032.6325","gluc_pyr_3_24hr":"1743846.409","pyr_1_24hr":"2350.147749","pyr_2_24hr":"124093.4283","pyr_3_24hr":"1576991.816"},{"Metabolite":"levulinic acid","ctrl_1_1hr":"21.65564088","ctrl_2_1hr":"410.6565323","ctrl_3_1hr":"213.7960355","gln_1_1hr":"NA","gln_2_1hr":"NA","gln_3_1hr":"NA","gln_gluc_1_1hr":"NA","gln_gluc_2_1hr":"NA","gln_gluc_3_1hr":"2.615925991","gln_pyr_1_1hr":"NA","gln_pyr_2_1hr":"NA","gln_pyr_3_1hr":"NA","gluc_1_1hr":"NA","gluc_2_1hr":"152.4355136","gluc_3_1hr":"148.8150471","gluc_pyr_1_1hr":"NA","gluc_pyr_2_1hr":"125.9825606","gluc_pyr_3_1hr":"220.3897239","pyr_1_1hr":"NA","pyr_2_1hr":"NA","pyr_3_1hr":"NA","ctrl_1_4hr":"NA","ctrl_2_4hr":"NA","ctrl_3_4hr":"NA","gln_1_4hr":"NA","gln_2_4hr":"48.51737934","gln_3_4hr":"59.00038198","gln_gluc_1_4hr":"NA","gln_gluc_2_4hr":"152.582744","gln_gluc_3_4hr":"91.05535938","gln_pyr_1_4hr":"NA","gln_pyr_2_4hr":"NA","gln_pyr_3_4hr":"NA","gluc_1_4hr":"NA","gluc_2_4hr":"NA","gluc_3_4hr":"NA","gluc_pyr_1_4hr":"NA","gluc_pyr_2_4hr":"54.47071566","gluc_pyr_3_4hr":"97.9104815","pyr_1_4hr":"NA","pyr_2_4hr":"191.0570777","pyr_3_4hr":"271.2701","ctrl_1_8hr":"NA","ctrl_2_8hr":"447.5868132","ctrl_3_8hr":"NA","gln_1_8hr":"1.161975118","gln_2_8hr":"486.9902616","gln_3_8hr":"318.987699","gln_gluc_1_8hr":"59.380963","gln_gluc_2_8hr":"651.021842","gln_gluc_3_8hr":"533.4726023","gln_pyr_1_8hr":"NA","gln_pyr_2_8hr":"NA","gln_pyr_3_8hr":"NA","gluc_1_8hr":"225.4820249","gluc_2_8hr":"1225.006656","gluc_3_8hr":"306.5106956","gluc_pyr_1_8hr":"NA","gluc_pyr_2_8hr":"473.4089995","gluc_pyr_3_8hr":"789.4616817","pyr_1_8hr":"33.65744063","pyr_2_8hr":"589.60935","pyr_3_8hr":"641.3843606","ctrl_1_24hr":"NA","ctrl_2_24hr":"NA","ctrl_3_24hr":"NA","gln_1_24hr":"3.903849383","gln_2_24hr":"559.8887671","gln_3_24hr":"668.7160927","gln_gluc_1_24hr":"NA","gln_gluc_2_24hr":"156.0339332","gln_gluc_3_24hr":"167.1764206","gln_pyr_1_24hr":"NA","gln_pyr_2_24hr":"58.00994284","gln_pyr_3_24hr":"NA","gluc_1_24hr":"NA","gluc_2_24hr":"NA","gluc_3_24hr":"NA","gluc_pyr_1_24hr":"NA","gluc_pyr_2_24hr":"86.87128032","gluc_pyr_3_24hr":"100.9549598","pyr_1_24hr":"NA","pyr_2_24hr":"NA","pyr_3_24hr":"NA"},{"Metabolite":"malate","ctrl_1_1hr":"6625.936431","ctrl_2_1hr":"20659.87792","ctrl_3_1hr":"539191.6234","gln_1_1hr":"1363.97051","gln_2_1hr":"7423.038949","gln_3_1hr":"NA","gln_gluc_1_1hr":"8877.467194","gln_gluc_2_1hr":"26267.8423","gln_gluc_3_1hr":"743591.1725","gln_pyr_1_1hr":"94.66195953","gln_pyr_2_1hr":"NA","gln_pyr_3_1hr":"NA","gluc_1_1hr":"2496.464979","gluc_2_1hr":"5331.978775","gluc_3_1hr":"243740.3969","gluc_pyr_1_1hr":"10787.58114","gluc_pyr_2_1hr":"32517.57171","gluc_pyr_3_1hr":"1055290.23","pyr_1_1hr":"2349.675794","pyr_2_1hr":"3236.845495","pyr_3_1hr":"175237.9786","ctrl_1_4hr":"240.5160146","ctrl_2_4hr":"NA","ctrl_3_4hr":"5268.265085","gln_1_4hr":"6931.048085","gln_2_4hr":"18792.73262","gln_3_4hr":"666150.9892","gln_gluc_1_4hr":"6117.552056","gln_gluc_2_4hr":"11387.00084","gln_gluc_3_4hr":"504384.1011","gln_pyr_1_4hr":"1214.980716","gln_pyr_2_4hr":"2230.979907","gln_pyr_3_4hr":"107710.5146","gluc_1_4hr":"6943.626859","gluc_2_4hr":"19790.15207","gluc_3_4hr":"602861.0958","gluc_pyr_1_4hr":"NA","gluc_pyr_2_4hr":"NA","gluc_pyr_3_4hr":"NA","pyr_1_4hr":"585.3034697","pyr_2_4hr":"109.30292","pyr_3_4hr":"330.3106168","ctrl_1_8hr":"10651.63464","ctrl_2_8hr":"30974.35298","ctrl_3_8hr":"908242.8921","gln_1_8hr":"NA","gln_2_8hr":"NA","gln_3_8hr":"NA","gln_gluc_1_8hr":"6498.554978","gln_gluc_2_8hr":"16582.90784","gln_gluc_3_8hr":"631247.1355","gln_pyr_1_8hr":"53.45243488","gln_pyr_2_8hr":"NA","gln_pyr_3_8hr":"NA","gluc_1_8hr":"7948.195453","gluc_2_8hr":"22471.53479","gluc_3_8hr":"796683.2776","gluc_pyr_1_8hr":"6942.867081","gluc_pyr_2_8hr":"14688.58045","gluc_pyr_3_8hr":"655334.6316","pyr_1_8hr":"1031.668205","pyr_2_8hr":"2468.939744","pyr_3_8hr":"93878.56532","ctrl_1_24hr":"4677.577974","ctrl_2_24hr":"13720.46099","ctrl_3_24hr":"389722.5364","gln_1_24hr":"6049.527727","gln_2_24hr":"17016.85137","gln_3_24hr":"598750.3603","gln_gluc_1_24hr":"1568.804274","gln_gluc_2_24hr":"4967.216048","gln_gluc_3_24hr":"109233.4113","gln_pyr_1_24hr":"185.7404995","gln_pyr_2_24hr":"NA","gln_pyr_3_24hr":"5526.565086","gluc_1_24hr":"8379.443924","gluc_2_24hr":"21335.94746","gluc_3_24hr":"738704.1527","gluc_pyr_1_24hr":"2384.89403","gluc_pyr_2_24hr":"4431.148465","gluc_pyr_3_24hr":"199643.2436","pyr_1_24hr":"226.6079026","pyr_2_24hr":"NA","pyr_3_24hr":"NA"},{"Metabolite":"malonate","ctrl_1_1hr":"NA","ctrl_2_1hr":"NA","ctrl_3_1hr":"189.6007697","gln_1_1hr":"150.941617","gln_2_1hr":"NA","gln_3_1hr":"405.6570411","gln_gluc_1_1hr":"NA","gln_gluc_2_1hr":"NA","gln_gluc_3_1hr":"NA","gln_pyr_1_1hr":"NA","gln_pyr_2_1hr":"NA","gln_pyr_3_1hr":"372.4117065","gluc_1_1hr":"12119.68766","gluc_2_1hr":"147.4251983","gluc_3_1hr":"NA","gluc_pyr_1_1hr":"12031.32136","gluc_pyr_2_1hr":"2866.388669","gluc_pyr_3_1hr":"451.7931767","pyr_1_1hr":"NA","pyr_2_1hr":"228.3819637","pyr_3_1hr":"156.0685532","ctrl_1_4hr":"NA","ctrl_2_4hr":"NA","ctrl_3_4hr":"NA","gln_1_4hr":"NA","gln_2_4hr":"NA","gln_3_4hr":"NA","gln_gluc_1_4hr":"NA","gln_gluc_2_4hr":"NA","gln_gluc_3_4hr":"NA","gln_pyr_1_4hr":"NA","gln_pyr_2_4hr":"749.8816079","gln_pyr_3_4hr":"122.4362423","gluc_1_4hr":"21.33879458","gluc_2_4hr":"NA","gluc_3_4hr":"146.3193544","gluc_pyr_1_4hr":"12573.12062","gluc_pyr_2_4hr":"1294.466234","gluc_pyr_3_4hr":"NA","pyr_1_4hr":"7042.242522","pyr_2_4hr":"1454.377247","pyr_3_4hr":"31.71044476","ctrl_1_8hr":"NA","ctrl_2_8hr":"NA","ctrl_3_8hr":"NA","gln_1_8hr":"NA","gln_2_8hr":"NA","gln_3_8hr":"NA","gln_gluc_1_8hr":"NA","gln_gluc_2_8hr":"NA","gln_gluc_3_8hr":"NA","gln_pyr_1_8hr":"NA","gln_pyr_2_8hr":"NA","gln_pyr_3_8hr":"NA","gluc_1_8hr":"NA","gluc_2_8hr":"NA","gluc_3_8hr":"NA","gluc_pyr_1_8hr":"NA","gluc_pyr_2_8hr":"NA","gluc_pyr_3_8hr":"NA","pyr_1_8hr":"1636.252398","pyr_2_8hr":"NA","pyr_3_8hr":"NA","ctrl_1_24hr":"3089.920543","ctrl_2_24hr":"153.9741494","ctrl_3_24hr":"106.5490344","gln_1_24hr":"19421.06908","gln_2_24hr":"3520.391272","gln_3_24hr":"128.7970334","gln_gluc_1_24hr":"135252.4361","gln_gluc_2_24hr":"38974.31221","gln_gluc_3_24hr":"7014.986225","gln_pyr_1_24hr":"204460.6017","gln_pyr_2_24hr":"55980.80319","gln_pyr_3_24hr":"9912.782295","gluc_1_24hr":"50894.7145","gluc_2_24hr":"15121.3509","gluc_3_24hr":"2766.287591","gluc_pyr_1_24hr":"2692.225395","gluc_pyr_2_24hr":"1238.368111","gluc_pyr_3_24hr":"NA","pyr_1_24hr":"1598.032871","pyr_2_24hr":"NA","pyr_3_24hr":"180.118473"},{"Metabolite":"methylmalonate","ctrl_1_1hr":"37.27896629","ctrl_2_1hr":"73.98739358","ctrl_3_1hr":"51.84101953","gln_1_1hr":"98.9908711","gln_2_1hr":"83.02692613","gln_3_1hr":"84.47550848","gln_gluc_1_1hr":"59.20920681","gln_gluc_2_1hr":"68.75087002","gln_gluc_3_1hr":"111.7971228","gln_pyr_1_1hr":"202.6300917","gln_pyr_2_1hr":"186.181218","gln_pyr_3_1hr":"60.70157551","gluc_1_1hr":"1008.047518","gluc_2_1hr":"1184.83789","gluc_3_1hr":"135.6549358","gluc_pyr_1_1hr":"168.5402667","gluc_pyr_2_1hr":"190.3652818","gluc_pyr_3_1hr":"54.82926908","pyr_1_1hr":"181.6935062","pyr_2_1hr":"87.86989123","pyr_3_1hr":"38.64529686","ctrl_1_4hr":"272.0910439","ctrl_2_4hr":"438.4327209","ctrl_3_4hr":"243.2594945","gln_1_4hr":"99.35330801","gln_2_4hr":"90.20744275","gln_3_4hr":"16.111131","gln_gluc_1_4hr":"19.24794514","gln_gluc_2_4hr":"33.65493439","gln_gluc_3_4hr":"154.1526336","gln_pyr_1_4hr":"60.23255322","gln_pyr_2_4hr":"99.07213873","gln_pyr_3_4hr":"43.67953307","gluc_1_4hr":"160.2768517","gluc_2_4hr":"151.7731371","gluc_3_4hr":"68.74606689","gluc_pyr_1_4hr":"436.1085025","gluc_pyr_2_4hr":"828.847393","gluc_pyr_3_4hr":"133.5736651","pyr_1_4hr":"227.46261","pyr_2_4hr":"202.3534572","pyr_3_4hr":"106.9424342","ctrl_1_8hr":"173.7159747","ctrl_2_8hr":"82.51583651","ctrl_3_8hr":"112.9453266","gln_1_8hr":"175.0739531","gln_2_8hr":"136.0485211","gln_3_8hr":"123.8975498","gln_gluc_1_8hr":"73.0684547","gln_gluc_2_8hr":"115.4425679","gln_gluc_3_8hr":"31.20437375","gln_pyr_1_8hr":"406.9456991","gln_pyr_2_8hr":"220.9069585","gln_pyr_3_8hr":"157.918204","gluc_1_8hr":"93.36163906","gluc_2_8hr":"22.61840884","gluc_3_8hr":"58.37831332","gluc_pyr_1_8hr":"10.46998404","gluc_pyr_2_8hr":"NA","gluc_pyr_3_8hr":"51.92663229","pyr_1_8hr":"196.5643996","pyr_2_8hr":"186.7480139","pyr_3_8hr":"10.88147533","ctrl_1_24hr":"31.58995304","ctrl_2_24hr":"48.24492046","ctrl_3_24hr":"29.40325102","gln_1_24hr":"144.7852711","gln_2_24hr":"193.1432259","gln_3_24hr":"75.88413839","gln_gluc_1_24hr":"1754.217903","gln_gluc_2_24hr":"1659.812299","gln_gluc_3_24hr":"1011.265364","gln_pyr_1_24hr":"785.2506741","gln_pyr_2_24hr":"1077.286752","gln_pyr_3_24hr":"125.2830041","gluc_1_24hr":"185.0619013","gluc_2_24hr":"190.4959705","gluc_3_24hr":"91.16542753","gluc_pyr_1_24hr":"331.3267735","gluc_pyr_2_24hr":"477.3940464","gluc_pyr_3_24hr":"37.54893976","pyr_1_24hr":"120.0689839","pyr_2_24hr":"187.5053408","pyr_3_24hr":"133.8066902"},{"Metabolite":"n-acetyl-beta-alanine","ctrl_1_1hr":"NA","ctrl_2_1hr":"NA","ctrl_3_1hr":"NA","gln_1_1hr":"NA","gln_2_1hr":"NA","gln_3_1hr":"6.987492846","gln_gluc_1_1hr":"NA","gln_gluc_2_1hr":"NA","gln_gluc_3_1hr":"NA","gln_pyr_1_1hr":"NA","gln_pyr_2_1hr":"18.11943472","gln_pyr_3_1hr":"19.16177368","gluc_1_1hr":"NA","gluc_2_1hr":"NA","gluc_3_1hr":"NA","gluc_pyr_1_1hr":"NA","gluc_pyr_2_1hr":"NA","gluc_pyr_3_1hr":"8.837436841","pyr_1_1hr":"NA","pyr_2_1hr":"NA","pyr_3_1hr":"5.640046147","ctrl_1_4hr":"1.220182235","ctrl_2_4hr":"NA","ctrl_3_4hr":"21.17955091","gln_1_4hr":"NA","gln_2_4hr":"NA","gln_3_4hr":"9.318068058","gln_gluc_1_4hr":"NA","gln_gluc_2_4hr":"NA","gln_gluc_3_4hr":"NA","gln_pyr_1_4hr":"NA","gln_pyr_2_4hr":"NA","gln_pyr_3_4hr":"13.14490286","gluc_1_4hr":"24.12234194","gluc_2_4hr":"39.0554293","gluc_3_4hr":"27.54721008","gluc_pyr_1_4hr":"7.818590072","gluc_pyr_2_4hr":"4.289410615","gluc_pyr_3_4hr":"20.53688682","pyr_1_4hr":"NA","pyr_2_4hr":"NA","pyr_3_4hr":"17.82167426","ctrl_1_8hr":"NA","ctrl_2_8hr":"NA","ctrl_3_8hr":"NA","gln_1_8hr":"NA","gln_2_8hr":"NA","gln_3_8hr":"NA","gln_gluc_1_8hr":"NA","gln_gluc_2_8hr":"NA","gln_gluc_3_8hr":"NA","gln_pyr_1_8hr":"NA","gln_pyr_2_8hr":"NA","gln_pyr_3_8hr":"4.088518966","gluc_1_8hr":"49.09669388","gluc_2_8hr":"76.85312959","gluc_3_8hr":"36.98423767","gluc_pyr_1_8hr":"NA","gluc_pyr_2_8hr":"NA","gluc_pyr_3_8hr":"NA","pyr_1_8hr":"NA","pyr_2_8hr":"NA","pyr_3_8hr":"15.25057558","ctrl_1_24hr":"NA","ctrl_2_24hr":"NA","ctrl_3_24hr":"NA","gln_1_24hr":"21.56394642","gln_2_24hr":"NA","gln_3_24hr":"28.86017712","gln_gluc_1_24hr":"NA","gln_gluc_2_24hr":"NA","gln_gluc_3_24hr":"2.888820736","gln_pyr_1_24hr":"NA","gln_pyr_2_24hr":"NA","gln_pyr_3_24hr":"NA","gluc_1_24hr":"NA","gluc_2_24hr":"NA","gluc_3_24hr":"NA","gluc_pyr_1_24hr":"24.28899394","gluc_pyr_2_24hr":"63.4325425","gluc_pyr_3_24hr":"25.25987431","pyr_1_24hr":"15.30094593","pyr_2_24hr":"23.27534253","pyr_3_24hr":"21.70535344"},{"Metabolite":"n-acetyl-isoleucine","ctrl_1_1hr":"73.89895631","ctrl_2_1hr":"109.9040438","ctrl_3_1hr":"146.7848315","gln_1_1hr":"54.15750957","gln_2_1hr":"49.82999686","gln_3_1hr":"427.7042663","gln_gluc_1_1hr":"52.35363144","gln_gluc_2_1hr":"74.20134797","gln_gluc_3_1hr":"61.96758664","gln_pyr_1_1hr":"87.49532045","gln_pyr_2_1hr":"54.84589943","gln_pyr_3_1hr":"238.0219369","gluc_1_1hr":"284.4773364","gluc_2_1hr":"118.354023","gluc_3_1hr":"350.6357357","gluc_pyr_1_1hr":"98.54693762","gluc_pyr_2_1hr":"76.95083754","gluc_pyr_3_1hr":"177.9634273","pyr_1_1hr":"293.8864592","pyr_2_1hr":"299.2931356","pyr_3_1hr":"634.090277","ctrl_1_4hr":"68.62479947","ctrl_2_4hr":"88.99365256","ctrl_3_4hr":"74.87299854","gln_1_4hr":"58.62570653","gln_2_4hr":"61.16370505","gln_3_4hr":"101.5059838","gln_gluc_1_4hr":"31.37350325","gln_gluc_2_4hr":"2.034085838","gln_gluc_3_4hr":"9.897200449","gln_pyr_1_4hr":"43.35959699","gln_pyr_2_4hr":"50.68875436","gln_pyr_3_4hr":"287.3058627","gluc_1_4hr":"33.47688949","gluc_2_4hr":"104.762783","gluc_3_4hr":"40.44183803","gluc_pyr_1_4hr":"41.15991759","gluc_pyr_2_4hr":"49.88832708","gluc_pyr_3_4hr":"172.4660866","pyr_1_4hr":"59.43958388","pyr_2_4hr":"148.8786953","pyr_3_4hr":"149.1319667","ctrl_1_8hr":"110.5947892","ctrl_2_8hr":"60.90397172","ctrl_3_8hr":"NA","gln_1_8hr":"237.2800046","gln_2_8hr":"126.6827045","gln_3_8hr":"625.8479609","gln_gluc_1_8hr":"207.70139","gln_gluc_2_8hr":"48.59579391","gln_gluc_3_8hr":"389.5339854","gln_pyr_1_8hr":"596.0343782","gln_pyr_2_8hr":"69.62358457","gln_pyr_3_8hr":"637.3168579","gluc_1_8hr":"68.7489174","gluc_2_8hr":"132.906017","gluc_3_8hr":"86.08176075","gluc_pyr_1_8hr":"15.93739923","gluc_pyr_2_8hr":"107.8521825","gluc_pyr_3_8hr":"NA","pyr_1_8hr":"18.90111907","pyr_2_8hr":"29.87733133","pyr_3_8hr":"291.5348092","ctrl_1_24hr":"87.27195255","ctrl_2_24hr":"108.7119845","ctrl_3_24hr":"NA","gln_1_24hr":"93.51932722","gln_2_24hr":"217.7107197","gln_3_24hr":"149.0580554","gln_gluc_1_24hr":"108.4491509","gln_gluc_2_24hr":"71.94628008","gln_gluc_3_24hr":"299.9755918","gln_pyr_1_24hr":"97.69355086","gln_pyr_2_24hr":"12.83426365","gln_pyr_3_24hr":"367.7293255","gluc_1_24hr":"93.2235334","gluc_2_24hr":"32.68627926","gluc_3_24hr":"234.874617","gluc_pyr_1_24hr":"28.35400248","gluc_pyr_2_24hr":"72.93375629","gluc_pyr_3_24hr":"NA","pyr_1_24hr":"161.7713479","pyr_2_24hr":"207.0079618","pyr_3_24hr":"156.2346566"},{"Metabolite":"n-acetylalanine","ctrl_1_1hr":"28.75456086","ctrl_2_1hr":"91.49437247","ctrl_3_1hr":"2414.993282","gln_1_1hr":"84.13631054","gln_2_1hr":"87.53293598","gln_3_1hr":"1255.930619","gln_gluc_1_1hr":"NA","gln_gluc_2_1hr":"27.34550426","gln_gluc_3_1hr":"901.3651026","gln_pyr_1_1hr":"NA","gln_pyr_2_1hr":"17.46524794","gln_pyr_3_1hr":"548.3120072","gluc_1_1hr":"NA","gluc_2_1hr":"23.48808631","gluc_3_1hr":"NA","gluc_pyr_1_1hr":"31.1507051","gluc_pyr_2_1hr":"72.8270816","gluc_pyr_3_1hr":"365.8144108","pyr_1_1hr":"5.7954396","pyr_2_1hr":"64.18782759","pyr_3_1hr":"2936.798406","ctrl_1_4hr":"137.6765264","ctrl_2_4hr":"128.6834856","ctrl_3_4hr":"547.5478075","gln_1_4hr":"43.55476089","gln_2_4hr":"78.93057836","gln_3_4hr":"2430.560272","gln_gluc_1_4hr":"45.21320899","gln_gluc_2_4hr":"94.42875471","gln_gluc_3_4hr":"293.314653","gln_pyr_1_4hr":"NA","gln_pyr_2_4hr":"21.03404019","gln_pyr_3_4hr":"166.5908664","gluc_1_4hr":"76.53556013","gluc_2_4hr":"78.60931618","gluc_3_4hr":"544.0029835","gluc_pyr_1_4hr":"NA","gluc_pyr_2_4hr":"30.76056568","gluc_pyr_3_4hr":"216.7003606","pyr_1_4hr":"NA","pyr_2_4hr":"47.40749239","pyr_3_4hr":"497.7579991","ctrl_1_8hr":"NA","ctrl_2_8hr":"29.58845178","ctrl_3_8hr":"4872.747167","gln_1_8hr":"NA","gln_2_8hr":"59.57894075","gln_3_8hr":"2795.427363","gln_gluc_1_8hr":"NA","gln_gluc_2_8hr":"68.14688256","gln_gluc_3_8hr":"542.2292338","gln_pyr_1_8hr":"NA","gln_pyr_2_8hr":"18.43284259","gln_pyr_3_8hr":"NA","gluc_1_8hr":"98.15553514","gluc_2_8hr":"52.05172735","gluc_3_8hr":"245.3569794","gluc_pyr_1_8hr":"NA","gluc_pyr_2_8hr":"55.95827106","gluc_pyr_3_8hr":"NA","pyr_1_8hr":"215.3450182","pyr_2_8hr":"39.15324056","pyr_3_8hr":"NA","ctrl_1_24hr":"NA","ctrl_2_24hr":"33.28933936","ctrl_3_24hr":"NA","gln_1_24hr":"190.75912","gln_2_24hr":"101.4499257","gln_3_24hr":"1143.555288","gln_gluc_1_24hr":"13.73917281","gln_gluc_2_24hr":"81.13966641","gln_gluc_3_24hr":"2245.354827","gln_pyr_1_24hr":"NA","gln_pyr_2_24hr":"32.42363994","gln_pyr_3_24hr":"1032.913386","gluc_1_24hr":"NA","gluc_2_24hr":"11.53048544","gluc_3_24hr":"NA","gluc_pyr_1_24hr":"145.8271557","gluc_pyr_2_24hr":"92.98640322","gluc_pyr_3_24hr":"1681.901401","pyr_1_24hr":"NA","pyr_2_24hr":"47.34818507","pyr_3_24hr":"321.5347128"},{"Metabolite":"n-acetylasparagine","ctrl_1_1hr":"1.521889539","ctrl_2_1hr":"0.079174666","ctrl_3_1hr":"2.976969257","gln_1_1hr":"30.75698996","gln_2_1hr":"14.90344033","gln_3_1hr":"18.20406023","gln_gluc_1_1hr":"5.021583632","gln_gluc_2_1hr":"8.242768691","gln_gluc_3_1hr":"4.086344079","gln_pyr_1_1hr":"4.697164949","gln_pyr_2_1hr":"10.82305733","gln_pyr_3_1hr":"8.205678843","gluc_1_1hr":"22.43022185","gluc_2_1hr":"16.87911628","gluc_3_1hr":"14.71077143","gluc_pyr_1_1hr":"1.153944818","gluc_pyr_2_1hr":"NA","gluc_pyr_3_1hr":"1.415619932","pyr_1_1hr":"1.17561442","pyr_2_1hr":"NA","pyr_3_1hr":"1.118436038","ctrl_1_4hr":"5.079693391","ctrl_2_4hr":"2.362966048","ctrl_3_4hr":"5.411740713","gln_1_4hr":"4.200711768","gln_2_4hr":"3.299650022","gln_3_4hr":"4.327822337","gln_gluc_1_4hr":"2.394627379","gln_gluc_2_4hr":"NA","gln_gluc_3_4hr":"2.560640745","gln_pyr_1_4hr":"31.00377119","gln_pyr_2_4hr":"47.29745551","gln_pyr_3_4hr":"40.42623667","gluc_1_4hr":"4.328647895","gluc_2_4hr":"4.839234711","gluc_3_4hr":"5.889541816","gluc_pyr_1_4hr":"5.714458404","gluc_pyr_2_4hr":"4.100788279","gluc_pyr_3_4hr":"3.954798495","pyr_1_4hr":"4.499636252","pyr_2_4hr":"NA","pyr_3_4hr":"NA","ctrl_1_8hr":"4.584197067","ctrl_2_8hr":"3.56692511","ctrl_3_8hr":"4.100851778","gln_1_8hr":"57.37909876","gln_2_8hr":"76.48412919","gln_3_8hr":"63.89310742","gln_gluc_1_8hr":"31.9910074","gln_gluc_2_8hr":"42.20685266","gln_gluc_3_8hr":"34.78688506","gln_pyr_1_8hr":"10.24892002","gln_pyr_2_8hr":"8.557245742","gln_pyr_3_8hr":"5.778782408","gluc_1_8hr":"5.659235704","gluc_2_8hr":"7.489231164","gluc_3_8hr":"5.440625508","gluc_pyr_1_8hr":"2.617205158","gluc_pyr_2_8hr":"4.90198881","gluc_pyr_3_8hr":"3.530870661","pyr_1_8hr":"NA","pyr_2_8hr":"NA","pyr_3_8hr":"NA","ctrl_1_24hr":"20.58573458","ctrl_2_24hr":"20.81805169","ctrl_3_24hr":"14.00590655","gln_1_24hr":"196.9103432","gln_2_24hr":"238.592194","gln_3_24hr":"185.9676845","gln_gluc_1_24hr":"49.42789082","gln_gluc_2_24hr":"50.54465021","gln_gluc_3_24hr":"50.04451337","gln_pyr_1_24hr":"41.80194842","gln_pyr_2_24hr":"49.16653221","gln_pyr_3_24hr":"40.32506626","gluc_1_24hr":"5.435146257","gluc_2_24hr":"3.346179309","gluc_3_24hr":"2.563714105","gluc_pyr_1_24hr":"NA","gluc_pyr_2_24hr":"NA","gluc_pyr_3_24hr":"NA","pyr_1_24hr":"29.42420188","pyr_2_24hr":"17.22084588","pyr_3_24hr":"25.81946791"},{"Metabolite":"n-acetylglycine","ctrl_1_1hr":"60.60920778","ctrl_2_1hr":"236.6238539","ctrl_3_1hr":"347.6084501","gln_1_1hr":"NA","gln_2_1hr":"11.90402037","gln_3_1hr":"103.4372547","gln_gluc_1_1hr":"95.86897657","gln_gluc_2_1hr":"53.85996361","gln_gluc_3_1hr":"98.63024312","gln_pyr_1_1hr":"NA","gln_pyr_2_1hr":"12.34250712","gln_pyr_3_1hr":"20.86334501","gluc_1_1hr":"4.370749032","gluc_2_1hr":"19.20449675","gluc_3_1hr":"22.77797954","gluc_pyr_1_1hr":"NA","gluc_pyr_2_1hr":"17.88192571","gluc_pyr_3_1hr":"46.20140213","pyr_1_1hr":"116.4856349","pyr_2_1hr":"21.97987664","pyr_3_1hr":"0.585359835","ctrl_1_4hr":"9.97322038","ctrl_2_4hr":"18.74668621","ctrl_3_4hr":"16.37015201","gln_1_4hr":"35.16870041","gln_2_4hr":"28.22206418","gln_3_4hr":"NA","gln_gluc_1_4hr":"23.13381232","gln_gluc_2_4hr":"34.08872964","gln_gluc_3_4hr":"106.8055753","gln_pyr_1_4hr":"NA","gln_pyr_2_4hr":"150.5653947","gln_pyr_3_4hr":"254.8183022","gluc_1_4hr":"NA","gluc_2_4hr":"22.4597011","gluc_3_4hr":"12.12655062","gluc_pyr_1_4hr":"323.8772005","gluc_pyr_2_4hr":"29.36834396","gluc_pyr_3_4hr":"40.88699592","pyr_1_4hr":"46.7297899","pyr_2_4hr":"12.40672113","pyr_3_4hr":"19.94191431","ctrl_1_8hr":"22.79962023","ctrl_2_8hr":"23.13087889","ctrl_3_8hr":"16.68185203","gln_1_8hr":"20.05483532","gln_2_8hr":"17.12203178","gln_3_8hr":"150.8007583","gln_gluc_1_8hr":"26.09481882","gln_gluc_2_8hr":"55.52691835","gln_gluc_3_8hr":"228.4755167","gln_pyr_1_8hr":"34.47614609","gln_pyr_2_8hr":"20.02414749","gln_pyr_3_8hr":"81.9259085","gluc_1_8hr":"NA","gluc_2_8hr":"16.38453769","gluc_3_8hr":"13.99208019","gluc_pyr_1_8hr":"NA","gluc_pyr_2_8hr":"NA","gluc_pyr_3_8hr":"55.05242711","pyr_1_8hr":"5.598487107","pyr_2_8hr":"60.89984502","pyr_3_8hr":"941.3260242","ctrl_1_24hr":"NA","ctrl_2_24hr":"15.76337051","ctrl_3_24hr":"NA","gln_1_24hr":"25.74835577","gln_2_24hr":"23.48158329","gln_3_24hr":"8.778334114","gln_gluc_1_24hr":"222.5147955","gln_gluc_2_24hr":"57.28680751","gln_gluc_3_24hr":"21.93968021","gln_pyr_1_24hr":"43.76896706","gln_pyr_2_24hr":"40.88280239","gln_pyr_3_24hr":"67.35280351","gluc_1_24hr":"213.5064671","gluc_2_24hr":"33.85567928","gluc_3_24hr":"NA","gluc_pyr_1_24hr":"62.74739258","gluc_pyr_2_24hr":"16.34933115","gluc_pyr_3_24hr":"37.33853109","pyr_1_24hr":"3.875046018","pyr_2_24hr":"53.28168358","pyr_3_24hr":"421.5215062"},{"Metabolite":"n-acetylproline","ctrl_1_1hr":"NA","ctrl_2_1hr":"136.4313636","ctrl_3_1hr":"47.81702713","gln_1_1hr":"1.512880602","gln_2_1hr":"0.69306454","gln_3_1hr":"46.55514091","gln_gluc_1_1hr":"13.65329292","gln_gluc_2_1hr":"NA","gln_gluc_3_1hr":"15.45162696","gln_pyr_1_1hr":"16.39344366","gln_pyr_2_1hr":"NA","gln_pyr_3_1hr":"14.55261112","gluc_1_1hr":"NA","gluc_2_1hr":"99.2088175","gluc_3_1hr":"72.94902555","gluc_pyr_1_1hr":"14.58754729","gluc_pyr_2_1hr":"23.03810425","gluc_pyr_3_1hr":"22.27142771","pyr_1_1hr":"NA","pyr_2_1hr":"217.5268906","pyr_3_1hr":"37.61314876","ctrl_1_4hr":"9.602586255","ctrl_2_4hr":"57.88379049","ctrl_3_4hr":"24.12925095","gln_1_4hr":"NA","gln_2_4hr":"804.1535284","gln_3_4hr":"99.60149159","gln_gluc_1_4hr":"15.81393279","gln_gluc_2_4hr":"NA","gln_gluc_3_4hr":"15.27692145","gln_pyr_1_4hr":"NA","gln_pyr_2_4hr":"159.5844017","gln_pyr_3_4hr":"58.38315116","gluc_1_4hr":"0.553942124","gluc_2_4hr":"NA","gluc_3_4hr":"6.878650545","gluc_pyr_1_4hr":"6.140989964","gluc_pyr_2_4hr":"102.0192999","gluc_pyr_3_4hr":"34.06976309","pyr_1_4hr":"12.62127357","pyr_2_4hr":"58.80251181","pyr_3_4hr":"13.61259013","ctrl_1_8hr":"NA","ctrl_2_8hr":"160.1792763","ctrl_3_8hr":"37.9650231","gln_1_8hr":"6.862895212","gln_2_8hr":"108.7473607","gln_3_8hr":"17.18748106","gln_gluc_1_8hr":"25.58792621","gln_gluc_2_8hr":"NA","gln_gluc_3_8hr":"4.224131874","gln_pyr_1_8hr":"7.305285827","gln_pyr_2_8hr":"55.43282497","gln_pyr_3_8hr":"37.07114411","gluc_1_8hr":"21.39152798","gluc_2_8hr":"NA","gluc_3_8hr":"9.042477648","gluc_pyr_1_8hr":"18.87272604","gluc_pyr_2_8hr":"NA","gluc_pyr_3_8hr":"8.24061623","pyr_1_8hr":"20.21082786","pyr_2_8hr":"NA","pyr_3_8hr":"3.711511836","ctrl_1_24hr":"16.76644561","ctrl_2_24hr":"NA","ctrl_3_24hr":"10.29739662","gln_1_24hr":"13.01047713","gln_2_24hr":"NA","gln_3_24hr":"17.89246258","gln_gluc_1_24hr":"6.327539492","gln_gluc_2_24hr":"NA","gln_gluc_3_24hr":"21.59947558","gln_pyr_1_24hr":"3.739039004","gln_pyr_2_24hr":"68.42249465","gln_pyr_3_24hr":"17.62402339","gluc_1_24hr":"16.5035884","gluc_2_24hr":"NA","gluc_3_24hr":"15.78780416","gluc_pyr_1_24hr":"20.80368965","gluc_pyr_2_24hr":"NA","gluc_pyr_3_24hr":"NA","pyr_1_24hr":"13.46417215","pyr_2_24hr":"NA","pyr_3_24hr":"9.336260891"},{"Metabolite":"pantothenate","ctrl_1_1hr":"2224.948951","ctrl_2_1hr":"1551.211082","ctrl_3_1hr":"256.0725718","gln_1_1hr":"214.3481481","gln_2_1hr":"258.929487","gln_3_1hr":"158.6088795","gln_gluc_1_1hr":"70.25368237","gln_gluc_2_1hr":"28.97558424","gln_gluc_3_1hr":"149.5276181","gln_pyr_1_1hr":"172.1073447","gln_pyr_2_1hr":"42.94397233","gln_pyr_3_1hr":"211.508144","gluc_1_1hr":"802.5367245","gluc_2_1hr":"780.1439235","gluc_3_1hr":"537.1481658","gluc_pyr_1_1hr":"14.20140944","gluc_pyr_2_1hr":"NA","gluc_pyr_3_1hr":"126.8975601","pyr_1_1hr":"228.8303094","pyr_2_1hr":"441.6991126","pyr_3_1hr":"718.2821861","ctrl_1_4hr":"3481.743212","ctrl_2_4hr":"6055.826156","ctrl_3_4hr":"908.3512245","gln_1_4hr":"195.4178233","gln_2_4hr":"68.17991139","gln_3_4hr":"167.948985","gln_gluc_1_4hr":"314.1850512","gln_gluc_2_4hr":"68.13676411","gln_gluc_3_4hr":"469.7539293","gln_pyr_1_4hr":"NA","gln_pyr_2_4hr":"NA","gln_pyr_3_4hr":"252.4385144","gluc_1_4hr":"NA","gluc_2_4hr":"NA","gluc_3_4hr":"88.28477318","gluc_pyr_1_4hr":"1776.350466","gluc_pyr_2_4hr":"2456.055209","gluc_pyr_3_4hr":"441.8641733","pyr_1_4hr":"122.1431495","pyr_2_4hr":"NA","pyr_3_4hr":"150.5076337","ctrl_1_8hr":"2639.730213","ctrl_2_8hr":"2259.836364","ctrl_3_8hr":"98.1132505","gln_1_8hr":"NA","gln_2_8hr":"NA","gln_3_8hr":"182.6803664","gln_gluc_1_8hr":"588.4692409","gln_gluc_2_8hr":"426.7175762","gln_gluc_3_8hr":"376.1714108","gln_pyr_1_8hr":"2869.952037","gln_pyr_2_8hr":"4820.133457","gln_pyr_3_8hr":"637.5149087","gluc_1_8hr":"395.8854313","gluc_2_8hr":"176.1617286","gluc_3_8hr":"220.4039713","gluc_pyr_1_8hr":"682.4709567","gluc_pyr_2_8hr":"541.1843498","gluc_pyr_3_8hr":"314.5323154","pyr_1_8hr":"2283.280012","pyr_2_8hr":"2717.26834","pyr_3_8hr":"1221.764188","ctrl_1_24hr":"NA","ctrl_2_24hr":"NA","ctrl_3_24hr":"163.0560929","gln_1_24hr":"67.6832671","gln_2_24hr":"61.22629672","gln_3_24hr":"251.0748547","gln_gluc_1_24hr":"NA","gln_gluc_2_24hr":"NA","gln_gluc_3_24hr":"48.48817097","gln_pyr_1_24hr":"836.4704633","gln_pyr_2_24hr":"975.7993552","gln_pyr_3_24hr":"600.9756171","gluc_1_24hr":"84.84148502","gluc_2_24hr":"NA","gluc_3_24hr":"239.3664026","gluc_pyr_1_24hr":"3326.830996","gluc_pyr_2_24hr":"4627.77221","gluc_pyr_3_24hr":"1696.115236","pyr_1_24hr":"16.48562433","pyr_2_24hr":"NA","pyr_3_24hr":"154.9253673"},{"Metabolite":"pyroglutamate","ctrl_1_1hr":"30117.14837","ctrl_2_1hr":"30853.14518","ctrl_3_1hr":"NA","gln_1_1hr":"21810.95487","gln_2_1hr":"17987.74985","gln_3_1hr":"3211.332206","gln_gluc_1_1hr":"19038.66098","gln_gluc_2_1hr":"15839.5855","gln_gluc_3_1hr":"29731.63151","gln_pyr_1_1hr":"25620.22287","gln_pyr_2_1hr":"15868.53894","gln_pyr_3_1hr":"11647.84149","gluc_1_1hr":"24990.08635","gluc_2_1hr":"29205.57259","gluc_3_1hr":"39343.28886","gluc_pyr_1_1hr":"21130.9475","gluc_pyr_2_1hr":"16191.10119","gluc_pyr_3_1hr":"3548.701367","pyr_1_1hr":"25004.85996","pyr_2_1hr":"30772.44398","pyr_3_1hr":"NA","ctrl_1_4hr":"61756.58665","ctrl_2_4hr":"28070.03979","ctrl_3_4hr":"37095.48314","gln_1_4hr":"14714.92938","gln_2_4hr":"10040.54774","gln_3_4hr":"12361.13565","gln_gluc_1_4hr":"11119.30767","gln_gluc_2_4hr":"9605.955151","gln_gluc_3_4hr":"68045.3022","gln_pyr_1_4hr":"11150.24562","gln_pyr_2_4hr":"12526.37902","gln_pyr_3_4hr":"25029.05891","gluc_1_4hr":"22863.71476","gluc_2_4hr":"27625.29105","gluc_3_4hr":"23792.18402","gluc_pyr_1_4hr":"18022.13642","gluc_pyr_2_4hr":"21350.45581","gluc_pyr_3_4hr":"NA","pyr_1_4hr":"37110.82817","pyr_2_4hr":"31632.99955","pyr_3_4hr":"16891.86452","ctrl_1_8hr":"32214.43228","ctrl_2_8hr":"26894.10783","ctrl_3_8hr":"35337.29341","gln_1_8hr":"8336.38116","gln_2_8hr":"10343.4379","gln_3_8hr":"NA","gln_gluc_1_8hr":"7083.144601","gln_gluc_2_8hr":"7642.392834","gln_gluc_3_8hr":"NA","gln_pyr_1_8hr":"7632.771914","gln_pyr_2_8hr":"6193.957479","gln_pyr_3_8hr":"31054.26754","gluc_1_8hr":"22401.3438","gluc_2_8hr":"26457.36491","gluc_3_8hr":"180.744822","gluc_pyr_1_8hr":"22304.11358","gluc_pyr_2_8hr":"21644.91034","gluc_pyr_3_8hr":"12144.41573","pyr_1_8hr":"28253.22341","pyr_2_8hr":"31203.70621","pyr_3_8hr":"944.9998019","ctrl_1_24hr":"41017.86148","ctrl_2_24hr":"16268.63138","ctrl_3_24hr":"6560.960361","gln_1_24hr":"4864.396475","gln_2_24hr":"4507.476906","gln_3_24hr":"16952.89365","gln_gluc_1_24hr":"3412.349855","gln_gluc_2_24hr":"3229.175622","gln_gluc_3_24hr":"19623.04232","gln_pyr_1_24hr":"8257.659624","gln_pyr_2_24hr":"1791.165507","gln_pyr_3_24hr":"1664.677051","gluc_1_24hr":"20812.68087","gluc_2_24hr":"23540.57816","gluc_3_24hr":"26909.28265","gluc_pyr_1_24hr":"37239.96236","gluc_pyr_2_24hr":"16371.61493","gluc_pyr_3_24hr":"1908.612681","pyr_1_24hr":"16644.33605","pyr_2_24hr":"28471.37677","pyr_3_24hr":"45696.14028"},{"Metabolite":"pyruvate","ctrl_1_1hr":"63489.83579","ctrl_2_1hr":"63046.92738","ctrl_3_1hr":"51730.35793","gln_1_1hr":"32504.3893","gln_2_1hr":"15214.52596","gln_3_1hr":"11227.80996","gln_gluc_1_1hr":"34206.83722","gln_gluc_2_1hr":"24533.58737","gln_gluc_3_1hr":"16701.40033","gln_pyr_1_1hr":"8951.432073","gln_pyr_2_1hr":"1796.280909","gln_pyr_3_1hr":"2456.042927","gluc_1_1hr":"47482.78906","gluc_2_1hr":"41465.60982","gluc_3_1hr":"26321.47127","gluc_pyr_1_1hr":"39940.93655","gluc_pyr_2_1hr":"24928.78704","gluc_pyr_3_1hr":"18752.50172","pyr_1_1hr":"93731.02534","pyr_2_1hr":"47152.36118","pyr_3_1hr":"45761.67205","ctrl_1_4hr":"8327.585707","ctrl_2_4hr":"5917.480702","ctrl_3_4hr":"3035.052069","gln_1_4hr":"34284.96835","gln_2_4hr":"24768.57607","gln_3_4hr":"13349.07261","gln_gluc_1_4hr":"19970.62942","gln_gluc_2_4hr":"19766.34775","gln_gluc_3_4hr":"10358.99702","gln_pyr_1_4hr":"31877.538","gln_pyr_2_4hr":"13103.95352","gln_pyr_3_4hr":"5912.87703","gluc_1_4hr":"14628.4695","gluc_2_4hr":"15418.27409","gluc_3_4hr":"7204.429894","gluc_pyr_1_4hr":"NA","gluc_pyr_2_4hr":"788.6778859","gluc_pyr_3_4hr":"2185.193537","pyr_1_4hr":"27363.14686","pyr_2_4hr":"31947.4622","pyr_3_4hr":"16878.94432","ctrl_1_8hr":"19081.08319","ctrl_2_8hr":"9902.374289","ctrl_3_8hr":"7192.322328","gln_1_8hr":"14505.98593","gln_2_8hr":"11459.31652","gln_3_8hr":"8746.406468","gln_gluc_1_8hr":"267410.8655","gln_gluc_2_8hr":"143525.0629","gln_gluc_3_8hr":"117384.4232","gln_pyr_1_8hr":"NA","gln_pyr_2_8hr":"743.9100498","gln_pyr_3_8hr":"2243.197838","gluc_1_8hr":"18410.69489","gluc_2_8hr":"15894.74543","gluc_3_8hr":"11344.95528","gluc_pyr_1_8hr":"32896.24748","gluc_pyr_2_8hr":"17913.60599","gluc_pyr_3_8hr":"14137.13195","pyr_1_8hr":"39173.47594","pyr_2_8hr":"29335.99286","pyr_3_8hr":"7301.136887","ctrl_1_24hr":"6405.737355","ctrl_2_24hr":"2926.273394","ctrl_3_24hr":"4973.817335","gln_1_24hr":"40637.38256","gln_2_24hr":"24946.51431","gln_3_24hr":"18818.39581","gln_gluc_1_24hr":"9329.299994","gln_gluc_2_24hr":"6606.45008","gln_gluc_3_24hr":"6609.103365","gln_pyr_1_24hr":"98913.59376","gln_pyr_2_24hr":"50863.79229","gln_pyr_3_24hr":"21512.28934","gluc_1_24hr":"23242.54044","gluc_2_24hr":"12710.41027","gluc_3_24hr":"4751.250966","gluc_pyr_1_24hr":"7013.294295","gluc_pyr_2_24hr":"4854.166654","gluc_pyr_3_24hr":"4061.182868","pyr_1_24hr":"435.3008359","pyr_2_24hr":"441.6295375","pyr_3_24hr":"3868.986519"},{"Metabolite":"sebacic acid","ctrl_1_1hr":"46.77275264","ctrl_2_1hr":"66.34838895","ctrl_3_1hr":"131.0756893","gln_1_1hr":"67.97949906","gln_2_1hr":"49.34163487","gln_3_1hr":"157.4549001","gln_gluc_1_1hr":"42.83969269","gln_gluc_2_1hr":"37.91491751","gln_gluc_3_1hr":"58.14789977","gln_pyr_1_1hr":"3.936091943","gln_pyr_2_1hr":"36.28173256","gln_pyr_3_1hr":"61.0625455","gluc_1_1hr":"30.43235025","gluc_2_1hr":"118.4185018","gluc_3_1hr":"98.92391541","gluc_pyr_1_1hr":"18.65567046","gluc_pyr_2_1hr":"39.11483208","gluc_pyr_3_1hr":"19.34011051","pyr_1_1hr":"5.464663245","pyr_2_1hr":"57.53157027","pyr_3_1hr":"NA","ctrl_1_4hr":"8.477169576","ctrl_2_4hr":"28.7572025","ctrl_3_4hr":"32.82487694","gln_1_4hr":"16.51883084","gln_2_4hr":"32.70218817","gln_3_4hr":"NA","gln_gluc_1_4hr":"24.30750334","gln_gluc_2_4hr":"27.1700312","gln_gluc_3_4hr":"98.9801099","gln_pyr_1_4hr":"32.21860048","gln_pyr_2_4hr":"80.33838684","gln_pyr_3_4hr":"65.28698169","gluc_1_4hr":"45.77264612","gluc_2_4hr":"46.45941949","gluc_3_4hr":"NA","gluc_pyr_1_4hr":"20.09174913","gluc_pyr_2_4hr":"20.6515806","gluc_pyr_3_4hr":"19.36782487","pyr_1_4hr":"27.3958546","pyr_2_4hr":"44.32508919","pyr_3_4hr":"211.3470276","ctrl_1_8hr":"30.21403652","ctrl_2_8hr":"50.48731499","ctrl_3_8hr":"135.4816572","gln_1_8hr":"36.68301378","gln_2_8hr":"49.63942382","gln_3_8hr":"99.3941276","gln_gluc_1_8hr":"9.17255651","gln_gluc_2_8hr":"91.78876319","gln_gluc_3_8hr":"38.02147171","gln_pyr_1_8hr":"137.6726798","gln_pyr_2_8hr":"75.0659538","gln_pyr_3_8hr":"197.4222139","gluc_1_8hr":"0.445669593","gluc_2_8hr":"165.9066176","gluc_3_8hr":"91.90100265","gluc_pyr_1_8hr":"35.9931411","gluc_pyr_2_8hr":"42.97734243","gluc_pyr_3_8hr":"31.3256969","pyr_1_8hr":"21.07409466","pyr_2_8hr":"33.41070799","pyr_3_8hr":"134.9804409","ctrl_1_24hr":"40.74533199","ctrl_2_24hr":"42.6055868","ctrl_3_24hr":"6.529922","gln_1_24hr":"6.269647766","gln_2_24hr":"43.52307594","gln_3_24hr":"40.95858173","gln_gluc_1_24hr":"23.20171697","gln_gluc_2_24hr":"33.26156291","gln_gluc_3_24hr":"NA","gln_pyr_1_24hr":"14.4216593","gln_pyr_2_24hr":"39.18191143","gln_pyr_3_24hr":"NA","gluc_1_24hr":"52.21810903","gluc_2_24hr":"42.2162263","gluc_3_24hr":"NA","gluc_pyr_1_24hr":"3.440421735","gluc_pyr_2_24hr":"49.03390732","gluc_pyr_3_24hr":"NA","pyr_1_24hr":"20.66809951","pyr_2_24hr":"54.85841747","pyr_3_24hr":"NA"},{"Metabolite":"suberate","ctrl_1_1hr":"48.42102327","ctrl_2_1hr":"NA","ctrl_3_1hr":"NA","gln_1_1hr":"241.6614499","gln_2_1hr":"NA","gln_3_1hr":"2432.130738","gln_gluc_1_1hr":"NA","gln_gluc_2_1hr":"NA","gln_gluc_3_1hr":"NA","gln_pyr_1_1hr":"1755.114595","gln_pyr_2_1hr":"30.68976578","gln_pyr_3_1hr":"1225.421665","gluc_1_1hr":"1271.993075","gluc_2_1hr":"NA","gluc_3_1hr":"532.5887213","gluc_pyr_1_1hr":"NA","gluc_pyr_2_1hr":"NA","gluc_pyr_3_1hr":"NA","pyr_1_1hr":"774.3967498","pyr_2_1hr":"0.469337394","pyr_3_1hr":"526.293948","ctrl_1_4hr":"406.3961163","ctrl_2_4hr":"NA","ctrl_3_4hr":"860.4850002","gln_1_4hr":"NA","gln_2_4hr":"NA","gln_3_4hr":"NA","gln_gluc_1_4hr":"NA","gln_gluc_2_4hr":"NA","gln_gluc_3_4hr":"80.23066381","gln_pyr_1_4hr":"NA","gln_pyr_2_4hr":"NA","gln_pyr_3_4hr":"1118.694056","gluc_1_4hr":"293.6329099","gluc_2_4hr":"NA","gluc_3_4hr":"148.748723","gluc_pyr_1_4hr":"4450.565792","gluc_pyr_2_4hr":"68.75669418","gluc_pyr_3_4hr":"5297.803156","pyr_1_4hr":"953.4868792","pyr_2_4hr":"NA","pyr_3_4hr":"1793.86819","ctrl_1_8hr":"NA","ctrl_2_8hr":"NA","ctrl_3_8hr":"NA","gln_1_8hr":"638.9266767","gln_2_8hr":"NA","gln_3_8hr":"NA","gln_gluc_1_8hr":"NA","gln_gluc_2_8hr":"NA","gln_gluc_3_8hr":"NA","gln_pyr_1_8hr":"NA","gln_pyr_2_8hr":"NA","gln_pyr_3_8hr":"NA","gluc_1_8hr":"NA","gluc_2_8hr":"NA","gluc_3_8hr":"NA","gluc_pyr_1_8hr":"NA","gluc_pyr_2_8hr":"NA","gluc_pyr_3_8hr":"NA","pyr_1_8hr":"1153.736408","pyr_2_8hr":"3.016434172","pyr_3_8hr":"392.383648","ctrl_1_24hr":"NA","ctrl_2_24hr":"NA","ctrl_3_24hr":"153.8584923","gln_1_24hr":"1006.239465","gln_2_24hr":"NA","gln_3_24hr":"1373.124748","gln_gluc_1_24hr":"NA","gln_gluc_2_24hr":"NA","gln_gluc_3_24hr":"NA","gln_pyr_1_24hr":"160.4102388","gln_pyr_2_24hr":"NA","gln_pyr_3_24hr":"1171.135161","gluc_1_24hr":"393.0713286","gluc_2_24hr":"NA","gluc_3_24hr":"31.94585161","gluc_pyr_1_24hr":"2273.177931","gluc_pyr_2_24hr":"NA","gluc_pyr_3_24hr":"NA","pyr_1_24hr":"2217.403312","pyr_2_24hr":"11.8344158","pyr_3_24hr":"3790.712769"},{"Metabolite":"succinate","ctrl_1_1hr":"167.7382605","ctrl_2_1hr":"1798.04314","ctrl_3_1hr":"NA","gln_1_1hr":"588.7101968","gln_2_1hr":"589.5968477","gln_3_1hr":"402.1168871","gln_gluc_1_1hr":"252.2794215","gln_gluc_2_1hr":"836.0716916","gln_gluc_3_1hr":"529.6074031","gln_pyr_1_1hr":"705.7180808","gln_pyr_2_1hr":"3822.404135","gln_pyr_3_1hr":"495.587927","gluc_1_1hr":"4549.988312","gluc_2_1hr":"32823.75216","gluc_3_1hr":"764.6791689","gluc_pyr_1_1hr":"773.7144249","gluc_pyr_2_1hr":"5842.090433","gluc_pyr_3_1hr":"408.2801693","pyr_1_1hr":"405.3481632","pyr_2_1hr":"3940.198087","pyr_3_1hr":"86.81905276","ctrl_1_4hr":"993.790979","ctrl_2_4hr":"8456.757757","ctrl_3_4hr":"1826.780338","gln_1_4hr":"483.2748854","gln_2_4hr":"1093.31969","gln_3_4hr":"NA","gln_gluc_1_4hr":"163.9970402","gln_gluc_2_4hr":"NA","gln_gluc_3_4hr":"1127.710645","gln_pyr_1_4hr":"245.2520358","gln_pyr_2_4hr":"982.7777482","gln_pyr_3_4hr":"83.77631296","gluc_1_4hr":"536.0471763","gluc_2_4hr":"5314.591668","gluc_3_4hr":"675.5701057","gluc_pyr_1_4hr":"1692.724531","gluc_pyr_2_4hr":"18903.36041","gluc_pyr_3_4hr":"641.524818","pyr_1_4hr":"867.5812298","pyr_2_4hr":"4468.631256","pyr_3_4hr":"809.3319456","ctrl_1_8hr":"805.5751764","ctrl_2_8hr":"1807.144107","ctrl_3_8hr":"455.1712063","gln_1_8hr":"858.8834787","gln_2_8hr":"4136.979143","gln_3_8hr":"685.8631862","gln_gluc_1_8hr":"374.6860311","gln_gluc_2_8hr":"1603.121701","gln_gluc_3_8hr":"NA","gln_pyr_1_8hr":"1810.582239","gln_pyr_2_8hr":"5906.314507","gln_pyr_3_8hr":"1095.823866","gluc_1_8hr":"736.8826464","gluc_2_8hr":"NA","gluc_3_8hr":"233.7064268","gluc_pyr_1_8hr":"63.89767917","gluc_pyr_2_8hr":"NA","gluc_pyr_3_8hr":"50.25475036","pyr_1_8hr":"637.0884713","pyr_2_8hr":"4242.176898","pyr_3_8hr":"NA","ctrl_1_24hr":"247.392577","ctrl_2_24hr":"153.9032","ctrl_3_24hr":"NA","gln_1_24hr":"828.3637119","gln_2_24hr":"3296.272234","gln_3_24hr":"278.153181","gln_gluc_1_24hr":"10260.85872","gln_gluc_2_24hr":"37246.96828","gln_gluc_3_24hr":"10486.29946","gln_pyr_1_24hr":"3584.802843","gln_pyr_2_24hr":"24613.39241","gln_pyr_3_24hr":"668.0786804","gluc_1_24hr":"1336.12895","gluc_2_24hr":"1735.025648","gluc_3_24hr":"753.2614219","gluc_pyr_1_24hr":"1397.784216","gluc_pyr_2_24hr":"10570.88876","gluc_pyr_3_24hr":"369.0328609","pyr_1_24hr":"538.7186579","pyr_2_24hr":"3303.564563","pyr_3_24hr":"966.3094069"},{"Metabolite":"ureidopropionate","ctrl_1_1hr":"84.97377675","ctrl_2_1hr":"84.61168904","ctrl_3_1hr":"53.85006537","gln_1_1hr":"286.1142231","gln_2_1hr":"222.9675848","gln_3_1hr":"88.73614791","gln_gluc_1_1hr":"90.21832394","gln_gluc_2_1hr":"84.81688215","gln_gluc_3_1hr":"56.37069815","gln_pyr_1_1hr":"593.6096507","gln_pyr_2_1hr":"656.6665315","gln_pyr_3_1hr":"616.5217872","gluc_1_1hr":"91.77555548","gluc_2_1hr":"90.85782784","gluc_3_1hr":"59.90216137","gluc_pyr_1_1hr":"86.67884527","gluc_pyr_2_1hr":"84.81810693","gluc_pyr_3_1hr":"53.58958224","pyr_1_1hr":"219.6545761","pyr_2_1hr":"216.4487971","pyr_3_1hr":"142.0198131","ctrl_1_4hr":"340.75244","ctrl_2_4hr":"333.9986052","ctrl_3_4hr":"296.0712475","gln_1_4hr":"87.3148468","gln_2_4hr":"82.04358656","gln_3_4hr":"53.94519077","gln_gluc_1_4hr":"280.0165165","gln_gluc_2_4hr":"256.4955447","gln_gluc_3_4hr":"188.9645358","gln_pyr_1_4hr":"167.6237528","gln_pyr_2_4hr":"195.785129","gln_pyr_3_4hr":"138.6024181","gluc_1_4hr":"615.8770779","gluc_2_4hr":"443.7445093","gluc_3_4hr":"384.3864987","gluc_pyr_1_4hr":"420.2649733","gluc_pyr_2_4hr":"306.9829463","gluc_pyr_3_4hr":"332.3092297","pyr_1_4hr":"231.0571418","pyr_2_4hr":"225.208742","pyr_3_4hr":"223.2471453","ctrl_1_8hr":"89.54319644","ctrl_2_8hr":"85.02526464","ctrl_3_8hr":"52.41866342","gln_1_8hr":"90.07991385","gln_2_8hr":"85.69799483","gln_3_8hr":"54.68147694","gln_gluc_1_8hr":"85.50989321","gln_gluc_2_8hr":"82.01483842","gln_gluc_3_8hr":"48.39807273","gln_pyr_1_8hr":"135.3862632","gln_pyr_2_8hr":"122.8448315","gln_pyr_3_8hr":"123.1449783","gluc_1_8hr":"277.8992223","gluc_2_8hr":"293.9086433","gluc_3_8hr":"351.1575806","gluc_pyr_1_8hr":"109.1901249","gluc_pyr_2_8hr":"90.7618053","gluc_pyr_3_8hr":"55.94312644","pyr_1_8hr":"89.33186872","pyr_2_8hr":"84.70759266","pyr_3_8hr":"54.87307019","ctrl_1_24hr":"100.7614706","ctrl_2_24hr":"91.33490567","ctrl_3_24hr":"61.36696422","gln_1_24hr":"465.8007388","gln_2_24hr":"490.5064645","gln_3_24hr":"227.9090252","gln_gluc_1_24hr":"95.42399344","gln_gluc_2_24hr":"88.55142449","gln_gluc_3_24hr":"53.73513626","gln_pyr_1_24hr":"250.4975515","gln_pyr_2_24hr":"246.7851718","gln_pyr_3_24hr":"243.6668306","gluc_1_24hr":"244.125595","gluc_2_24hr":"253.7572559","gluc_3_24hr":"151.3253235","gluc_pyr_1_24hr":"370.6846308","gluc_pyr_2_24hr":"252.4071859","gluc_pyr_3_24hr":"283.2891947","pyr_1_24hr":"307.9617736","pyr_2_24hr":"281.9169546","pyr_3_24hr":"324.8143084"}],

"Metabolites":[{"metabolite_name":"(+/-)-3-methyl-2-oxovaleric acid sodium salt"},{"metabolite_name":"2-oxobutyric acid"},{"metabolite_name":"4-acetamidobutanoate"},{"metabolite_name":"4-imidazoleacetate"},{"metabolite_name":"adipic acid"},{"metabolite_name":"akg"},{"metabolite_name":"azelate"},{"metabolite_name":"benzoate"},{"metabolite_name":"butyric acid"},{"metabolite_name":"fumarate"},{"metabolite_name":"glutarate"},{"metabolite_name":"hexanoate"},{"metabolite_name":"lactate"},{"metabolite_name":"levulinic acid"},{"metabolite_name":"malate"},{"metabolite_name":"malonate"},{"metabolite_name":"methylmalonate"},{"metabolite_name":"n-acetyl-beta-alanine"},{"metabolite_name":"n-acetyl-isoleucine"},{"metabolite_name":"n-acetylalanine"},{"metabolite_name":"n-acetylasparagine"},{"metabolite_name":"n-acetylglycine"},{"metabolite_name":"n-acetylproline"},{"metabolite_name":"pantothenate"},{"metabolite_name":"pyroglutamate"},{"metabolite_name":"pyruvate"},{"metabolite_name":"sebacic acid"},{"metabolite_name":"suberate"},{"metabolite_name":"succinate"},{"metabolite_name":"ureidopropionate"}]
}

}