#METABOLOMICS WORKBENCH ZJ309_20240802_054706 DATATRACK_ID:5075 STUDY_ID:ST003400 ANALYSIS_ID:AN005580 PROJECT_ID:PR002106 VERSION 1 CREATED_ON August 10, 2024, 9:09 am #PROJECT PR:PROJECT_TITLE A Study on the Mechanism of Perinatal BPS Exposure Promoting Obesity Based on PR:PROJECT_TITLE Metabolomics and Microbiomics PR:PROJECT_SUMMARY Due to increasingly stringent regulations on bisphenol A (BPA) usage, its PR:PROJECT_SUMMARY structurally similar counterpart, BPS, has become widely employed as the primary PR:PROJECT_SUMMARY substitute in various industries such as food packaging. However, recent years PR:PROJECT_SUMMARY have unveiled potential risks of obesity promotion and insulin resistance PR:PROJECT_SUMMARY associated with BPS, particularly during early life stages, although its precise PR:PROJECT_SUMMARY impact remains inadequately understood. Addressing these concerns, this study PR:PROJECT_SUMMARY established a mouse model to investigate the effects of maternal BPS exposure PR:PROJECT_SUMMARY during pregnancy and lactation, combined with offspring consumption of a PR:PROJECT_SUMMARY high-fat diet. The research examined physiological indicators related to obesity PR:PROJECT_SUMMARY and insulin resistance in offspring, evaluated pathological changes in vital PR:PROJECT_SUMMARY organs including the heart, liver, pancreas, white adipose tissue, and brown PR:PROJECT_SUMMARY adipose tissue, conducted metabolomics perturbation analysis across multiple PR:PROJECT_SUMMARY organs, and performed microbiome analysis based on fecal samples. Finally, PR:PROJECT_SUMMARY correlations between phenotype, metabolome, and microbiome were explored to PR:PROJECT_SUMMARY unravel intergenerational effects and mechanisms under BPS exposure, aiming to PR:PROJECT_SUMMARY identify potential biomarkers of its effects. PR:INSTITUTE College of Marine Food and Biological Engineering, Jimei University PR:LAST_NAME Li PR:FIRST_NAME Shuyin PR:ADDRESS No. 185 Yinjiang Road, Jimei District, Xiamen City, Fujian Province, China PR:EMAIL 164000107@qq.com PR:PHONE 18750682266 #STUDY ST:STUDY_TITLE A Study on the Mechanism of Perinatal BPS Exposure Promoting Obesity Based on ST:STUDY_TITLE Metabolomics and Microbiomics ST:STUDY_SUMMARY Due to increasingly stringent regulations on bisphenol A (BPA) usage, its ST:STUDY_SUMMARY structurally similar counterpart, BPS, has become widely employed as the primary ST:STUDY_SUMMARY substitute in various industries such as food packaging. However, recent years ST:STUDY_SUMMARY have unveiled potential risks of obesity promotion and insulin resistance ST:STUDY_SUMMARY associated with BPS, particularly during early life stages, although its precise ST:STUDY_SUMMARY impact remains inadequately understood. Addressing these concerns, this study ST:STUDY_SUMMARY established a mouse model to investigate the effects of maternal BPS exposure ST:STUDY_SUMMARY during pregnancy and lactation, combined with offspring consumption of a ST:STUDY_SUMMARY high-fat diet. The research examined physiological indicators related to obesity ST:STUDY_SUMMARY and insulin resistance in offspring, evaluated pathological changes in vital ST:STUDY_SUMMARY organs including the heart, liver, pancreas, white adipose tissue (WAT), and ST:STUDY_SUMMARY brown adipose tissue (BAT), conducted metabolomics perturbation analysis across ST:STUDY_SUMMARY multiple organs, and performed microbiome analysis based on fecal samples. ST:STUDY_SUMMARY Finally, correlations between phenotype, metabolome, and microbiome were ST:STUDY_SUMMARY explored to unravel intergenerational effects and mechanisms under BPS exposure, ST:STUDY_SUMMARY aiming to identify potential biomarkers of its effects. ST:INSTITUTE College of Marine Food and Biological Engineering, Jimei University ST:LAST_NAME Li ST:FIRST_NAME Shuyin ST:ADDRESS No.185 Yinjiang Road,Jimei District,Xiamen City,Fujian Province,China ST:EMAIL 164000107@qq.com ST:PHONE 18750682266 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #FACTORS #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - BCF-223 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-223.raw SUBJECT_SAMPLE_FACTORS - BCF-226 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-226.raw SUBJECT_SAMPLE_FACTORS - BCF-227 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-227.raw SUBJECT_SAMPLE_FACTORS - BCF-228 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-228.raw SUBJECT_SAMPLE_FACTORS - BCF-229 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-229.raw SUBJECT_SAMPLE_FACTORS - BCF-230 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-230.raw SUBJECT_SAMPLE_FACTORS - BCF-231 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-231.raw SUBJECT_SAMPLE_FACTORS - BCM-233 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-233.raw SUBJECT_SAMPLE_FACTORS - BCM-234 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-234.raw SUBJECT_SAMPLE_FACTORS - BCM-236 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-236.raw SUBJECT_SAMPLE_FACTORS - BCM-237 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-237.raw SUBJECT_SAMPLE_FACTORS - BCM-238 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-238.raw SUBJECT_SAMPLE_FACTORS - BCM-243 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-243.raw SUBJECT_SAMPLE_FACTORS - BCM-246 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-246.raw SUBJECT_SAMPLE_FACTORS - BHF-295 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-295.raw SUBJECT_SAMPLE_FACTORS - BHF-297 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-297.raw SUBJECT_SAMPLE_FACTORS - BHF-298 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-298.raw SUBJECT_SAMPLE_FACTORS - BHF-299 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-299.raw SUBJECT_SAMPLE_FACTORS - BHF-306 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-306.raw SUBJECT_SAMPLE_FACTORS - BHF-307 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-307.raw SUBJECT_SAMPLE_FACTORS - BHF-4413 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4413.raw SUBJECT_SAMPLE_FACTORS - BHF-4415 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4415.raw SUBJECT_SAMPLE_FACTORS - BHF-4416 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4416.raw SUBJECT_SAMPLE_FACTORS - BHF-4417 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4417.raw SUBJECT_SAMPLE_FACTORS - BHF-4418 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4418.raw SUBJECT_SAMPLE_FACTORS - BHF-4419 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4419.raw SUBJECT_SAMPLE_FACTORS - BHF-4438 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4438.raw SUBJECT_SAMPLE_FACTORS - BHM-289 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-289.raw SUBJECT_SAMPLE_FACTORS - BHM-290 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-290.raw SUBJECT_SAMPLE_FACTORS - BHM-294 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-294.raw SUBJECT_SAMPLE_FACTORS - BHM-300 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-300.raw SUBJECT_SAMPLE_FACTORS - BHM-301 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-301.raw SUBJECT_SAMPLE_FACTORS - BHM-304 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-304.raw SUBJECT_SAMPLE_FACTORS - BHM-305 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-305.raw SUBJECT_SAMPLE_FACTORS - BHM-4423 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4423.raw SUBJECT_SAMPLE_FACTORS - BHM-4427 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4427.raw SUBJECT_SAMPLE_FACTORS - BHM-4431 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4431.raw SUBJECT_SAMPLE_FACTORS - BHM-4432 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4432.raw SUBJECT_SAMPLE_FACTORS - BHM-4433 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4433.raw SUBJECT_SAMPLE_FACTORS - BHM-4434 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4434.raw SUBJECT_SAMPLE_FACTORS - BHM-4452 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4452.raw SUBJECT_SAMPLE_FACTORS - BLF-258 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-258.raw SUBJECT_SAMPLE_FACTORS - BLF-261 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-261.raw SUBJECT_SAMPLE_FACTORS - BLF-262 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-262.raw SUBJECT_SAMPLE_FACTORS - BLF-263 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-263.raw SUBJECT_SAMPLE_FACTORS - BLF-264 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-264.raw SUBJECT_SAMPLE_FACTORS - BLF-266 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-266.raw SUBJECT_SAMPLE_FACTORS - BLF-267 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-267.raw SUBJECT_SAMPLE_FACTORS - BLM-247 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-247.raw SUBJECT_SAMPLE_FACTORS - BLM-252 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-252.raw SUBJECT_SAMPLE_FACTORS - BLM-253 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-253.raw SUBJECT_SAMPLE_FACTORS - BLM-255 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-255.raw SUBJECT_SAMPLE_FACTORS - BLM-275 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-275.raw SUBJECT_SAMPLE_FACTORS - BLM-278 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-278.raw SUBJECT_SAMPLE_FACTORS - BLM-279 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-279.raw SUBJECT_SAMPLE_FACTORS - HCF-223 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-223.raw SUBJECT_SAMPLE_FACTORS - HCF-226 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-226.raw SUBJECT_SAMPLE_FACTORS - HCF-227 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-227.raw SUBJECT_SAMPLE_FACTORS - HCF-228 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-228.raw SUBJECT_SAMPLE_FACTORS - HCF-229 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-229.raw SUBJECT_SAMPLE_FACTORS - HCF-230 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-230.raw SUBJECT_SAMPLE_FACTORS - HCF-231 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-231.raw SUBJECT_SAMPLE_FACTORS - HCM-233 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-233.raw SUBJECT_SAMPLE_FACTORS - HCM-234 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-234.raw SUBJECT_SAMPLE_FACTORS - HCM-236 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-236.raw SUBJECT_SAMPLE_FACTORS - HCM-237 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-237.raw SUBJECT_SAMPLE_FACTORS - HCM-238 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-238.raw SUBJECT_SAMPLE_FACTORS - HCM-243 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-243.raw SUBJECT_SAMPLE_FACTORS - HCM-246 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-246.raw SUBJECT_SAMPLE_FACTORS - HHF-295 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-295.raw SUBJECT_SAMPLE_FACTORS - HHF-297 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-297.raw SUBJECT_SAMPLE_FACTORS - HHF-298 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-298.raw SUBJECT_SAMPLE_FACTORS - HHF-299 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-299.raw SUBJECT_SAMPLE_FACTORS - HHF-306 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-306.raw SUBJECT_SAMPLE_FACTORS - HHF-307 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-307.raw SUBJECT_SAMPLE_FACTORS - HHF-4413 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4413.raw SUBJECT_SAMPLE_FACTORS - HHF-4415 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4415.raw SUBJECT_SAMPLE_FACTORS - HHF-4416 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4416.raw SUBJECT_SAMPLE_FACTORS - HHF-4417 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4417.raw SUBJECT_SAMPLE_FACTORS - HHF-4418 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4418.raw SUBJECT_SAMPLE_FACTORS - HHF-4419 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4419.raw SUBJECT_SAMPLE_FACTORS - HHF-4438 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4438.raw SUBJECT_SAMPLE_FACTORS - HHM-289 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-289.raw SUBJECT_SAMPLE_FACTORS - HHM-290 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-290.raw SUBJECT_SAMPLE_FACTORS - HHM-294 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-294.raw SUBJECT_SAMPLE_FACTORS - HHM-300 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-300.raw SUBJECT_SAMPLE_FACTORS - HHM-301 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-301.raw SUBJECT_SAMPLE_FACTORS - HHM-304 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-304.raw SUBJECT_SAMPLE_FACTORS - HHM-305 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-305.raw SUBJECT_SAMPLE_FACTORS - HHM-4423 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4423.raw SUBJECT_SAMPLE_FACTORS - HHM-4427 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4427.raw SUBJECT_SAMPLE_FACTORS - HHM-4431 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4431.raw SUBJECT_SAMPLE_FACTORS - HHM-4432 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4432.raw SUBJECT_SAMPLE_FACTORS - HHM-4433 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4433.raw SUBJECT_SAMPLE_FACTORS - HHM-4434 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4434.raw SUBJECT_SAMPLE_FACTORS - HHM-4452 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4452.raw SUBJECT_SAMPLE_FACTORS - HLF-258 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-258.raw SUBJECT_SAMPLE_FACTORS - HLF-261 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-261.raw SUBJECT_SAMPLE_FACTORS - HLF-262 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-262.raw SUBJECT_SAMPLE_FACTORS - HLF-263 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-263.raw SUBJECT_SAMPLE_FACTORS - HLF-264 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-264.raw SUBJECT_SAMPLE_FACTORS - HLF-266 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-266.raw SUBJECT_SAMPLE_FACTORS - HLF-267 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-267.raw SUBJECT_SAMPLE_FACTORS - HLM-247 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-247.raw SUBJECT_SAMPLE_FACTORS - HLM-252 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-252.raw SUBJECT_SAMPLE_FACTORS - HLM-253 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-253.raw SUBJECT_SAMPLE_FACTORS - HLM-255 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-255.raw SUBJECT_SAMPLE_FACTORS - HLM-275 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-275.raw SUBJECT_SAMPLE_FACTORS - HLM-278 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-278.raw SUBJECT_SAMPLE_FACTORS - HLM-279 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-279.raw SUBJECT_SAMPLE_FACTORS - LCF-223 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-223.raw SUBJECT_SAMPLE_FACTORS - LCF-226 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-226.raw SUBJECT_SAMPLE_FACTORS - LCF-227 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-227.raw SUBJECT_SAMPLE_FACTORS - LCF-228 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-228.raw SUBJECT_SAMPLE_FACTORS - LCF-229 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-229.raw SUBJECT_SAMPLE_FACTORS - LCF-230 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-230.raw SUBJECT_SAMPLE_FACTORS - LCF-231 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-231.raw SUBJECT_SAMPLE_FACTORS - LCM-233 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-233.raw SUBJECT_SAMPLE_FACTORS - LCM-234 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-234.raw SUBJECT_SAMPLE_FACTORS - LCM-236 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-236.raw SUBJECT_SAMPLE_FACTORS - LCM-237 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-237.raw SUBJECT_SAMPLE_FACTORS - LCM-238 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-238.raw SUBJECT_SAMPLE_FACTORS - LCM-243 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-243.raw SUBJECT_SAMPLE_FACTORS - LCM-246 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-246.raw SUBJECT_SAMPLE_FACTORS - LHF-295 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-295.raw SUBJECT_SAMPLE_FACTORS - LHF-297 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-297.raw SUBJECT_SAMPLE_FACTORS - LHF-298 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-298.raw SUBJECT_SAMPLE_FACTORS - LHF-299 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-299.raw SUBJECT_SAMPLE_FACTORS - LHF-306 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-306.raw SUBJECT_SAMPLE_FACTORS - LHF-307 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-307.raw SUBJECT_SAMPLE_FACTORS - LHF-4413 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4413.raw SUBJECT_SAMPLE_FACTORS - LHF-4415 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4415.raw SUBJECT_SAMPLE_FACTORS - LHF-4416 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4416.raw SUBJECT_SAMPLE_FACTORS - LHF-4417 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4417.raw SUBJECT_SAMPLE_FACTORS - LHF-4418 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4418.raw SUBJECT_SAMPLE_FACTORS - LHF-4419 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4419.raw SUBJECT_SAMPLE_FACTORS - LHF-4438 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4438.raw SUBJECT_SAMPLE_FACTORS - LHM-289 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-289.raw SUBJECT_SAMPLE_FACTORS - LHM-290 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-290.raw SUBJECT_SAMPLE_FACTORS - LHM-294 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-294.raw SUBJECT_SAMPLE_FACTORS - LHM-300 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-300.raw SUBJECT_SAMPLE_FACTORS - LHM-301 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-301.raw SUBJECT_SAMPLE_FACTORS - LHM-304 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-304.raw SUBJECT_SAMPLE_FACTORS - LHM-305 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-305.raw SUBJECT_SAMPLE_FACTORS - LHM-4423 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4423.raw SUBJECT_SAMPLE_FACTORS - LHM-4427 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4427.raw SUBJECT_SAMPLE_FACTORS - LHM-4431 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4431.raw SUBJECT_SAMPLE_FACTORS - LHM-4432 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4432.raw SUBJECT_SAMPLE_FACTORS - LHM-4433 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4433.raw SUBJECT_SAMPLE_FACTORS - LHM-4434 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4434.raw SUBJECT_SAMPLE_FACTORS - LHM-4452 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4452.raw SUBJECT_SAMPLE_FACTORS - LLF-258 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-258.raw SUBJECT_SAMPLE_FACTORS - LLF-261 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-261.raw SUBJECT_SAMPLE_FACTORS - LLF-262 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-262.raw SUBJECT_SAMPLE_FACTORS - LLF-263 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-263.raw SUBJECT_SAMPLE_FACTORS - LLF-264 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-264.raw SUBJECT_SAMPLE_FACTORS - LLF-266 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-266.raw SUBJECT_SAMPLE_FACTORS - LLF-267 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-267.raw SUBJECT_SAMPLE_FACTORS - LLM-247 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-247.raw SUBJECT_SAMPLE_FACTORS - LLM-252 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-252.raw SUBJECT_SAMPLE_FACTORS - LLM-253 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-253.raw SUBJECT_SAMPLE_FACTORS - LLM-255 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-255.raw SUBJECT_SAMPLE_FACTORS - LLM-275 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-275.raw SUBJECT_SAMPLE_FACTORS - LLM-278 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-278.raw SUBJECT_SAMPLE_FACTORS - LLM-279 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-279.raw SUBJECT_SAMPLE_FACTORS - PCF-223 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-223.raw SUBJECT_SAMPLE_FACTORS - PCF-226 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-226.raw SUBJECT_SAMPLE_FACTORS - PCF-227 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-227.raw SUBJECT_SAMPLE_FACTORS - PCF-228 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-228.raw SUBJECT_SAMPLE_FACTORS - PCF-229 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-229.raw SUBJECT_SAMPLE_FACTORS - PCF-230 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-230.raw SUBJECT_SAMPLE_FACTORS - PCF-231 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-231.raw SUBJECT_SAMPLE_FACTORS - PCM-233 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-233.raw SUBJECT_SAMPLE_FACTORS - PCM-234 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-234.raw SUBJECT_SAMPLE_FACTORS - PCM-236 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-236.raw SUBJECT_SAMPLE_FACTORS - PCM-237 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-237.raw SUBJECT_SAMPLE_FACTORS - PCM-238 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-238.raw SUBJECT_SAMPLE_FACTORS - PCM-243 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-243.raw SUBJECT_SAMPLE_FACTORS - PCM-246 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-246.raw SUBJECT_SAMPLE_FACTORS - PHF-295 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-295.raw SUBJECT_SAMPLE_FACTORS - PHF-297 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-297.raw SUBJECT_SAMPLE_FACTORS - PHF-298 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-298.raw SUBJECT_SAMPLE_FACTORS - PHF-299 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-299.raw SUBJECT_SAMPLE_FACTORS - PHF-306 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-306.raw SUBJECT_SAMPLE_FACTORS - PHF-307 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-307.raw SUBJECT_SAMPLE_FACTORS - PHF-4413 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4413.raw SUBJECT_SAMPLE_FACTORS - PHF-4415 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4415.raw SUBJECT_SAMPLE_FACTORS - PHF-4416 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4416.raw SUBJECT_SAMPLE_FACTORS - PHF-4417 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4417.raw SUBJECT_SAMPLE_FACTORS - PHF-4418 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4418.raw SUBJECT_SAMPLE_FACTORS - PHF-4419 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4419.raw SUBJECT_SAMPLE_FACTORS - PHF-4438 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4438.raw SUBJECT_SAMPLE_FACTORS - PHM-289 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-289.raw SUBJECT_SAMPLE_FACTORS - PHM-290 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-290.raw SUBJECT_SAMPLE_FACTORS - PHM-294 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-294.raw SUBJECT_SAMPLE_FACTORS - PHM-300 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-300.raw SUBJECT_SAMPLE_FACTORS - PHM-301 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-301.raw SUBJECT_SAMPLE_FACTORS - PHM-304 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-304.raw SUBJECT_SAMPLE_FACTORS - PHM-305 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-305.raw SUBJECT_SAMPLE_FACTORS - PHM-4423 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4423.raw SUBJECT_SAMPLE_FACTORS - PHM-4427 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4427.raw SUBJECT_SAMPLE_FACTORS - PHM-4431 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4431.raw SUBJECT_SAMPLE_FACTORS - PHM-4432 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4432.raw SUBJECT_SAMPLE_FACTORS - PHM-4433 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4433.raw SUBJECT_SAMPLE_FACTORS - PHM-4434 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4434.raw SUBJECT_SAMPLE_FACTORS - PHM-4452 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4452.raw SUBJECT_SAMPLE_FACTORS - PLF-258 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-258.raw SUBJECT_SAMPLE_FACTORS - PLF-261 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-261.raw SUBJECT_SAMPLE_FACTORS - PLF-262 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-262.raw SUBJECT_SAMPLE_FACTORS - PLF-263 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-263.raw SUBJECT_SAMPLE_FACTORS - PLF-264 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-264.raw SUBJECT_SAMPLE_FACTORS - PLF-266 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-266.raw SUBJECT_SAMPLE_FACTORS - PLF-267 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-267.raw SUBJECT_SAMPLE_FACTORS - PLM-247 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-247.raw SUBJECT_SAMPLE_FACTORS - PLM-252 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-252.raw SUBJECT_SAMPLE_FACTORS - PLM-253 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-253.raw SUBJECT_SAMPLE_FACTORS - PLM-255 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-255.raw SUBJECT_SAMPLE_FACTORS - PLM-275 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-275.raw SUBJECT_SAMPLE_FACTORS - PLM-278 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-278.raw SUBJECT_SAMPLE_FACTORS - PLM-279 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-279.raw SUBJECT_SAMPLE_FACTORS - WCF-223 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-223.raw SUBJECT_SAMPLE_FACTORS - WCF-226 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-226.raw SUBJECT_SAMPLE_FACTORS - WCF-227 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-227.raw SUBJECT_SAMPLE_FACTORS - WCF-228 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-228.raw SUBJECT_SAMPLE_FACTORS - WCF-229 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-229.raw SUBJECT_SAMPLE_FACTORS - WCF-230 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-230.raw SUBJECT_SAMPLE_FACTORS - WCF-231 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-231.raw SUBJECT_SAMPLE_FACTORS - WCM-233 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-233.raw SUBJECT_SAMPLE_FACTORS - WCM-234 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-234.raw SUBJECT_SAMPLE_FACTORS - WCM-236 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-236.raw SUBJECT_SAMPLE_FACTORS - WCM-237 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-237.raw SUBJECT_SAMPLE_FACTORS - WCM-238 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-238.raw SUBJECT_SAMPLE_FACTORS - WCM-243 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-243.raw SUBJECT_SAMPLE_FACTORS - WCM-246 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-246.raw SUBJECT_SAMPLE_FACTORS - WHF-295 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-295.raw SUBJECT_SAMPLE_FACTORS - WHF-297 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-297.raw SUBJECT_SAMPLE_FACTORS - WHF-298 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-298.raw SUBJECT_SAMPLE_FACTORS - WHF-299 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-299.raw SUBJECT_SAMPLE_FACTORS - WHF-306 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-306.raw SUBJECT_SAMPLE_FACTORS - WHF-307 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-307.raw SUBJECT_SAMPLE_FACTORS - WHF-4413 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4413.raw SUBJECT_SAMPLE_FACTORS - WHF-4415 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4415.raw SUBJECT_SAMPLE_FACTORS - WHF-4416 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4416.raw SUBJECT_SAMPLE_FACTORS - WHF-4417 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4417.raw SUBJECT_SAMPLE_FACTORS - WHF-4418 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4418.raw SUBJECT_SAMPLE_FACTORS - WHF-4419 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4419.raw SUBJECT_SAMPLE_FACTORS - WHF-4438 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4438.raw SUBJECT_SAMPLE_FACTORS - WHM-289 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-289.raw SUBJECT_SAMPLE_FACTORS - WHM-290 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-290.raw SUBJECT_SAMPLE_FACTORS - WHM-294 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-294.raw SUBJECT_SAMPLE_FACTORS - WHM-300 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-300.raw SUBJECT_SAMPLE_FACTORS - WHM-301 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-301.raw SUBJECT_SAMPLE_FACTORS - WHM-304 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-304.raw SUBJECT_SAMPLE_FACTORS - WHM-305 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-305.raw SUBJECT_SAMPLE_FACTORS - WHM-4423 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4423.raw SUBJECT_SAMPLE_FACTORS - WHM-4427 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4427.raw SUBJECT_SAMPLE_FACTORS - WHM-4431 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4431.raw SUBJECT_SAMPLE_FACTORS - WHM-4432 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4432.raw SUBJECT_SAMPLE_FACTORS - WHM-4433 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4433.raw SUBJECT_SAMPLE_FACTORS - WHM-4434 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4434.raw SUBJECT_SAMPLE_FACTORS - WHM-4452 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4452.raw SUBJECT_SAMPLE_FACTORS - WLF-258 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-258.raw SUBJECT_SAMPLE_FACTORS - WLF-261 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-261.raw SUBJECT_SAMPLE_FACTORS - WLF-262 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-262.raw SUBJECT_SAMPLE_FACTORS - WLF-263 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-263.raw SUBJECT_SAMPLE_FACTORS - WLF-264 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-264.raw SUBJECT_SAMPLE_FACTORS - WLF-266 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-266.raw SUBJECT_SAMPLE_FACTORS - WLF-267 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-267.raw SUBJECT_SAMPLE_FACTORS - WLM-247 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-247.raw SUBJECT_SAMPLE_FACTORS - WLM-252 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-252.raw SUBJECT_SAMPLE_FACTORS - WLM-253 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-253.raw SUBJECT_SAMPLE_FACTORS - WLM-255 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-255.raw SUBJECT_SAMPLE_FACTORS - WLM-275 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-275.raw SUBJECT_SAMPLE_FACTORS - WLM-278 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-278.raw SUBJECT_SAMPLE_FACTORS - WLM-279 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-279.raw #COLLECTION CO:COLLECTION_SUMMARY After 3 weeks of breastfeeding, F1 mice were fed adaptive diet for 1 week, CO:COLLECTION_SUMMARY followed by high-fat diet for 8 weeks.After mouse feces were collected,the CO:COLLECTION_SUMMARY method of euthanizing mice by cervical dislocation. After sampling, Mouse heart, CO:COLLECTION_SUMMARY liver, pancreas, white adipose and brown adipose were collected. After sampling, CO:COLLECTION_SUMMARY the tissues were quickly washed in normal saline. After cleaning, the tissues CO:COLLECTION_SUMMARY were treated with liquid nitrogen and finally frozen in the refrigerator at -80 CO:COLLECTION_SUMMARY ℃. CO:SAMPLE_TYPE White adipose,Brown adipose,Heart,Liver,Pancreas #TREATMENT TR:TREATMENT_SUMMARY Briefly,C57BL/6 pregnant mice were fed ordinary diet under constant temperature TR:TREATMENT_SUMMARY [(23±1) ℃] and constant humidity [(55±5)%], and followed a strict 12 h/12 h TR:TREATMENT_SUMMARY light/dark cycle.Animals were kept in polystyrene rat cages for the experiment. TR:TREATMENT_SUMMARY They were divided into normal saline solvent as control, low-dose BPS group TR:TREATMENT_SUMMARY (0.05 mg/kg/d) and high-dose BPS group (5 mg/kg/d). BPS exposure was performed TR:TREATMENT_SUMMARY by subcutaneous injection. The general state of pregnant mice was observed TR:TREATMENT_SUMMARY daily, and their body mass was weighed once a week. After delivery, pregnant TR:TREATMENT_SUMMARY rats were exposed to BPS in different groups during lactation period, and the TR:TREATMENT_SUMMARY mothers were killed after lactation period. After lactation, F1 mice were TR:TREATMENT_SUMMARY observed in general state every day and weighed once a week. After 3 weeks of TR:TREATMENT_SUMMARY breastfeeding, F1 mice were fed adaptive diet for 1 week, followed by high-fat TR:TREATMENT_SUMMARY diet for 8 weeks. Mouse feces were collected, and mouse heart, liver, pancreas, TR:TREATMENT_SUMMARY white adipose and brown adipose were collected. After sampling, the mice were TR:TREATMENT_SUMMARY quickly washed in normal saline. After cleaning, the mice were treated with TR:TREATMENT_SUMMARY liquid nitrogen and finally frozen in the refrigerator at -80 ℃. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Each replicate of mouse (1 tissue, ~15 mg) was accurately weighted and SP:SAMPLEPREP_SUMMARY transferred to an Eppendorf tube. Then, each sample was added 200 μL of Milli-Q SP:SAMPLEPREP_SUMMARY water,followed by tissue homogenization using the bead-based homogenizer SP:SAMPLEPREP_SUMMARY (Tissuelyser-24, Shanghai jingxin industrial development co., ltd, China) for 2 SP:SAMPLEPREP_SUMMARY min at 65 Hz twice and the other samples including white adipose and brown SP:SAMPLEPREP_SUMMARY adipose were homogenize for 2 min at 65 Hz four times. Next, each sample was SP:SAMPLEPREP_SUMMARY added with 800 μL of precooled MeOH/ACN（1:1,v/v）containing standards (i.e., SP:SAMPLEPREP_SUMMARY 0.49 μg/mL of Phenylalanine-d5(Phe-d5), 0.50 μg/mL of Tryptophan-d5(Trp-d5), SP:SAMPLEPREP_SUMMARY 0.25 μg/mL of Carnitine C2-d3, 0.40 μg/mL of Cholic acid-d4(CA-d4), 0.24 SP:SAMPLEPREP_SUMMARY μg/mL of Chenodeoxycholic acid-d4(CDCA-d4), 0.50 μg/mL of palmitic acid (fatty SP:SAMPLEPREP_SUMMARY acid (FA) (16:0))-d3, and 0.5 μg/mL of stearic acid (FA(18:0))-d3)，the SP:SAMPLEPREP_SUMMARY mixture was thoroughly vortexed for 30 s, use ultrasonic cleaning machine ice SP:SAMPLEPREP_SUMMARY bath for 10 min, stand at -20 °C for 1 h, centrifugation at 15,000 g for 15 min SP:SAMPLEPREP_SUMMARY at 4 ℃. The supernatant was collected and vacuum-dried in a refrigerated SP:SAMPLEPREP_SUMMARY CentriVap concentrator (Labconco, USA), followed by storage at -80 °C until SP:SAMPLEPREP_SUMMARY subsequent analysis. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Positive CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Dionex Ultimate 3000 CH:COLUMN_NAME Waters ACQUITY UPLC HSS C18 (100 x 2.1mm,1.8um) CH:SOLVENT_A 100% water; 0.1% formic acid CH:SOLVENT_B 100% acetonitrile; 0.1% formic acid CH:FLOW_GRADIENT First maintain 2% B for 0.5 minutes, then linearly increase from 0.5 to 12 CH:FLOW_GRADIENT minutes to 98% B, then rapidly decrease to 2% B at 0.1 minutes, maintain for 8.5 CH:FLOW_GRADIENT minutes,equilibrate until the next injection CH:FLOW_RATE 0.4 mL/min CH:COLUMN_TEMPERATURE 50 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive HF-X Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Xcalibular MS:MS_RESULTS_FILE ST003400_AN005580_Results.txt UNITS:Peak area Has m/z:Yes Has RT:Yes RT units:Minutes #END