{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003431","ANALYSIS_ID":"AN005635","VERSION":"1","CREATED_ON":"08-26-2024"},
"PROJECT":{"PROJECT_TITLE":"The shutdown of NADH oxidation via Respiratory Complex I mimics fatty acid biosynthesis inhibition","PROJECT_TYPE":"LC-MS Quantitative Analysis","PROJECT_SUMMARY":"Proliferating cancer cells actively utilize anabolic processes for biomass production, including de novo biosynthesis of amino acids, nucleotides, and fatty acids. The key enzyme of the fatty acid biosynthesis pathway, fatty acid synthase (FASN), is widely recognized as a promising therapeutic target in cancer and other health conditions. Here, we establish a metabolic signature of FASN inhibition using a panel of pharmacological inhibitors (GSK2194069, TVB-2640, TVB-3166, C75, cerulenin, and Fasnall). We find that the activity of some commonly used FASN inhibitors is inconsistent with the metabolic signature of FASN inhibition (accumulation of malonate, succinate, malonyl coenzyme A, succinyl coenzyme A, and other metabolic perturbations). Moreover, we show that one of these putative FASN inhibitors, Fasnall, is a respiratory Complex I inhibitor that mimics FASN inhibition through NADH accumulation and consequent depletion of the tricarboxylic acid cycle metabolites. We demonstrate that Fasnall impairs tumor growth in several oxidative phosphorylation-dependent cancer models, including combination therapy-resistant melanoma patient-derived xenografts. Fasnall administration does not reproduce neurological side effects in mice reported for other Complex I inhibitors. Our results have significant implications for understanding the FASN role in human health and disease and provide evidence of therapeutic potential for Complex I inhibitors with fast systemic clearance. Our findings also highlight the continuing need for validation of small molecule inhibitors to distinguish high-quality chemical probes and to expand the understanding of their application.","INSTITUTE":"Wistar Institute","DEPARTMENT":"Molecular and Cellular Oncogenesis Program, Ellen and Ronald Caplan Cancer Center","LABORATORY":"Schug's Lab","LAST_NAME":"Mukha","FIRST_NAME":"Dzmitry","ADDRESS":"3601 Spruce St., Philadelphia, Pennsylvania 19104, USA","EMAIL":"dmukha@wistar.org","PHONE":"+12154956903","FUNDING_SOURCE":"This work was supported by grants from the National Institutes of Health (NIH) National Cancer Institute (NCI) DP2 CA249950-01 (Z.T.S.), NIH NCI P01 CA114046 (Z.T.S.), Melanoma Research Foundation 717173 (Z.T.S.), and Susan G. Komen CCR19608782 (Z.T.S.).","PUBLICATIONS":"Submission Pending","DOI":"http://dx.doi.org/10.21228/M8TM76","CONTRIBUTORS":"Dzmitry Mukha, Jena Dessain, Seamus OâConnor, Katherine Pniewski, Fabrizio Bertolazzi, Jeet Patel, Mary Mullins, Zachary T. Schug"},
"STUDY":{"STUDY_TITLE":"Metabolomics analysis of breast cancer cell lines treated with dimethylmalonate (DMM), GSK2194069, and their combination.","STUDY_SUMMARY":"Seven breast cancer cell lines (MDA-MB-468, SUM159PT, MCF7, HCC1806, MDA-MB-231, HS578T, CAL120) were treated with 5 mM DMM, 1 uM GSK2194069, and their combination, for 24 h. Intracellular samples were collected for the metabolomics analysis.","INSTITUTE":"Wistar Institute","DEPARTMENT":"Molecular and Cellular Oncogenesis Program, Ellen and Ronald Caplan Cancer Center","LABORATORY":"Schug's Lab","LAST_NAME":"Mukha","FIRST_NAME":"Dzmitry","ADDRESS":"3601 Spruce St, Philadelphia, PA 19104, USA","EMAIL":"dmukha@wistar.org","PHONE":"+12154956903","SUBMIT_DATE":"2024-08-21"},
"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","GENDER":"Female","CELL_STRAIN_DETAILS":"MDA-MB-468, SUM159PT, MCF7, HCC1806, MDA-MB-231, HS578T, CAL120"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"40 CAL120 GSK 1 uM",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"43 CAL120 GSK 1 uM",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"39 CAL120 DMM 5 mM",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"42 CAL120 DMM 5 mM",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"41 CAL120 Combination",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"44 CAL120 Combination",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"22 HCC1806 GSK 1 uM",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"25 HCC1806 GSK 1 uM",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"21 HCC1806 DMM 5 mM",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"24 HCC1806 DMM 5 mM",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"23 HCC1806 Combination",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"26 HCC1806 Combination",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"34 HS578T GSK 1 uM",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"37 HS578T GSK 1 uM",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"33 HS578T DMM 5 mM",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"36 HS578T DMM 5 mM",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"35 HS578T Combination",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"38 HS578T Combination",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"16 MCF7 GSK 1 uM",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"19 MCF7 GSK 1 uM",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"15 MCF7 DMM 5 mM",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"18 MCF7 DMM 5 mM",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"17 MCF7 Combination",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"20 MCF7 Combination",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"28 MDA-MB-231 GSK 1 uM",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"31 MDA-MB-231 GSK 1 uM",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"27 MDA-MB-231 DMM 5 mM",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"30 MDA-MB-231 DMM 5 mM",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"29 MDA-MB-231 Combination",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"32 MDA-MB-231 Combination",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"04 MDA-MB-468 GSK 1 uM",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"07 MDA-MB-468 GSK 1 uM",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"03 MDA-MB-468 DMM 5 mM",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"06 MDA-MB-468 DMM 5 mM",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"05 MDA-MB-468 Combination",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"08 MDA-MB-468 Combination",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"01 Blank",
"Factors":{"Sample source":"NA","Sample Type":"Blank","Drug Treatment":"NA"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-Blank.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"46 Blank",
"Factors":{"Sample source":"NA","Sample Type":"Blank","Drug Treatment":"NA"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-Blank (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"02 DMEM/F12 no adds",
"Factors":{"Sample source":"NA","Sample Type":"QC","Drug Treatment":"NA"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-DMEM_F12 no adds.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"45 DMEM/F12 no adds",
"Factors":{"Sample source":"NA","Sample Type":"QC","Drug Treatment":"NA"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-DMEM_F12 no adds (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"10 SUM159PT GSK 1 uM",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"13 SUM159PT GSK 1 uM",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"09 SUM159PT DMM 5 mM",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"12 SUM159PT DMM 5 mM",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"11 SUM159PT Combination",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"14 SUM159PT Combination",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT Combination (2).mzML"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"For intracellular metabolite samples, the medium was aspirated, and cells were washed with PBS volume matching the volume of the medium. Metabolites were extracted with ice-cold 80% methanol. The volume of the solvent was 500 µl per 6-cm Petri dish (scaled according to the ratio of surface areas for other cell containers). After adding the methanol solution, cells were scraped from the plates, and all the content was transferred to Eppendorf tubes.","COLLECTION_PROTOCOL_FILENAME":"DM_metabolomics_samples.txt","SAMPLE_TYPE":"Breast cancer cells","COLLECTION_METHOD":"80% methanol extraction","STORAGE_CONDITIONS":"-80â","COLLECTION_VIALS":"1.5 ml plastic centrifuge tubes","STORAGE_VIALS":"1.5 ml plastic centrifuge tubes"},
"TREATMENT":{"TREATMENT_SUMMARY":"Cells were grown in RPMI-1640 supplemented with 10% dialyzed FBS and treated with various concentrations of rotenone for 24 h.","TREATMENT_COMPOUND":"Dimethylmalonate (DMM) and GSK2194069","TREATMENT_VEHICLE":"DMSO","CELL_GROWTH_CONTAINER":"6-cm Petri dishes","CELL_MEDIA":"RPMI-1640","CELL_ENVIR_COND":"37C, 5% CO2","CELL_PCT_CONFLUENCE":"~70%","CELL_MEDIA_LASTCHANGED":"24 h before collection"},
"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Intracellular metabolites were extracted with ice-cold 80% methanol, and medium samples were extracted with 100% methanol. The samples were centrifuged at 18,000 g 4C for 20 min. After transferring the supernatant to new tubes, centrifugation was repeated with the same parameters.","SAMPLEPREP_PROTOCOL_FILENAME":"DM_metabolomics_samples.txt","PROCESSING_STORAGE_CONDITIONS":"4â","EXTRACTION_METHOD":"80% methanol","EXTRACT_ENRICHMENT":"None","EXTRACT_CLEANUP":"None","EXTRACT_STORAGE":"-80â","SAMPLE_RESUSPENSION":"None","SAMPLE_DERIVATIZATION":"None","SAMPLE_SPIKING":"None","SUBCELLULAR_LOCATION":"Intracellular metabolites and medium metabolites"},
"CHROMATOGRAPHY":{"INSTRUMENT_NAME":"Shimadzu 20AD","COLUMN_NAME":"Merck SeQuant ZIC-HILIC (150 x 2.1mm,5um)","COLUMN_PRESSURE":"900-3000 psi","COLUMN_TEMPERATURE":"40","FLOW_GRADIENT":"0-12.5 min, 80-30% B; 12.5-15 min, 30% B; 15-15.2 min, 30-80% B; 15.2-22.5 min, 80% B","FLOW_RATE":"0-20 min, 0.2 ml/min; 20-21 min 0.2-0.3 ml/min; 21-22 min, 0.3 ml/min; 22-22.1 min, 0.2 ml/min; 22.1-22.5 min, 0.2 ml/min","INJECTION_TEMPERATURE":"4","SAMPLE_INJECTION":"1-5 ul","SOLVENT_A":"100% Water; 0.01% ammonium hydroxide; 20 mM ammonium bicarbonate","SOLVENT_B":"100% Acetonitrile","CHROMATOGRAPHY_TYPE":"HILIC"},
"ANALYSIS":{"LABORATORY_NAME":"Schug's Lab","ANALYSIS_TYPE":"MS","ACQUISITION_DATE":"03/18/2023","SOFTWARE_VERSION":"SCIEX Analyst 1.7.3","OPERATOR_NAME":"Dzmitry Mukha, Ph.D.","DETECTOR_TYPE":"High Energy Dynode (HED) and High-Capacity CEM (Continuous Electron Multiplier)","DATA_FORMAT":".WIFF"},
"MS":{"INSTRUMENT_NAME":"ABI Sciex 5500 QTrap","INSTRUMENT_TYPE":"QTRAP","MS_TYPE":"ESI","MS_COMMENTS":"Data were analyzed with SCIEX Multiquant 3.0.3.","ION_MODE":"NEGATIVE","CAPILLARY_TEMPERATURE":"500 °C","CAPILLARY_VOLTAGE":"-4500","DRY_GAS_FLOW":"70","DRY_GAS_TEMP":"500 °C","ION_SOURCE_TEMPERATURE":"500 °C","ION_SPRAY_VOLTAGE":"-4500","MASS_ACCURACY":"UNIT","SOURCE_TEMPERATURE":"500 °C","SPRAY_VOLTAGE":"-4500","DESOLVATION_GAS_FLOW":"70","DESOLVATION_TEMPERATURE":"500 °C"},
"MS_METABOLITE_DATA":{
"Units":"Counts per second (cps)",
"Data":[{"Metabolite":"2-Hydroxybutyric 17","40 CAL120 GSK 1 uM":"218.8952","43 CAL120 GSK 1 uM":"108.5935","39 CAL120 DMM 5 mM":"220.3897","42 CAL120 DMM 5 mM":"652.8054","41 CAL120 Combination":"311.2480","44 CAL120 Combination":"107.8668","22 HCC1806 GSK 1 uM":"108.8503","25 HCC1806 GSK 1 uM":"327.2144","21 HCC1806 DMM 5 mM":"433.7309","24 HCC1806 DMM 5 mM":"550.5736","23 HCC1806 Combination":"440.9740","26 HCC1806 Combination":"107.7165","34 HS578T GSK 1 uM":"103.3043","37 HS578T GSK 1 uM":"548.8454","33 HS578T DMM 5 mM":"107.8830","36 HS578T DMM 5 mM":"327.0617","35 HS578T Combination":"217.5042","38 HS578T Combination":"321.4724","16 MCF7 GSK 1 uM":"213.8312","19 MCF7 GSK 1 uM":"224.3809","15 MCF7 DMM 5 mM":"216.1069","18 MCF7 DMM 5 mM":"548.7108","17 MCF7 Combination":"648.6768","20 MCF7 Combination":"107.4919","28 MDA-MB-231 GSK 1 uM":"109.7133","31 MDA-MB-231 GSK 1 uM":"448.8736","27 MDA-MB-231 DMM 5 mM":"109.5490","30 MDA-MB-231 DMM 5 mM":"218.2053","29 MDA-MB-231 Combination":"436.3607","32 MDA-MB-231 Combination":"109.9681","04 MDA-MB-468 GSK 1 uM":"74.6234","07 MDA-MB-468 GSK 1 uM":"431.6277","03 MDA-MB-468 DMM 5 mM":"195.4199","06 MDA-MB-468 DMM 5 mM":"971.3736","05 MDA-MB-468 Combination":"213.4966","08 MDA-MB-468 Combination":"641.7060","01 Blank":"211.8622","46 Blank":"536.3193","02 DMEM/F12 no adds":"638.3099","45 DMEM/F12 no adds":"527.7045","10 SUM159PT GSK 1 uM":"736.4921","13 SUM159PT GSK 1 uM":"211.3251","09 SUM159PT DMM 5 mM":"443.7455","12 SUM159PT DMM 5 mM":"216.9067","11 SUM159PT Combination":"1453.7131","14 SUM159PT Combination":"333.4560"},{"Metabolite":"2-Hydroxybutyric 57","40 CAL120 GSK 1 uM":"667.4978","43 CAL120 GSK 1 uM":"4433.2797","39 CAL120 DMM 5 mM":"2452.6177","42 CAL120 DMM 5 mM":"1329.1075","41 CAL120 Combination":"368.5780","44 CAL120 Combination":"614.8542","22 HCC1806 GSK 1 uM":"2366.5929","25 HCC1806 GSK 1 uM":"5976.9560","21 HCC1806 DMM 5 mM":"3144.2462","24 HCC1806 DMM 5 mM":"3732.8088","23 HCC1806 Combination":"5951.2979","26 HCC1806 Combination":"2197.7092","34 HS578T GSK 1 uM":"3414.5612","37 HS578T GSK 1 uM":"2140.4216","33 HS578T DMM 5 mM":"10645.0797","36 HS578T DMM 5 mM":"16498.8510","35 HS578T Combination":"5539.5856","38 HS578T Combination":"13269.1979","16 MCF7 GSK 1 uM":"6323.5089","19 MCF7 GSK 1 uM":"7380.4409","15 MCF7 DMM 5 mM":"4729.2944","18 MCF7 DMM 5 mM":"26535.9957","17 MCF7 Combination":"1474.9891","20 MCF7 Combination":"3391.9617","28 MDA-MB-231 GSK 1 uM":"2880.7446","31 MDA-MB-231 GSK 1 uM":"3133.6788","27 MDA-MB-231 DMM 5 mM":"3207.0395","30 MDA-MB-231 DMM 5 mM":"5285.8775","29 MDA-MB-231 Combination":"6238.7702","32 MDA-MB-231 Combination":"763.0285","04 MDA-MB-468 GSK 1 uM":"15212.7024","07 MDA-MB-468 GSK 1 uM":"23340.8215","03 MDA-MB-468 DMM 5 mM":"4864.1670","06 MDA-MB-468 DMM 5 mM":"12841.1429","05 MDA-MB-468 Combination":"8378.9680","08 MDA-MB-468 Combination":"7721.7540","01 Blank":"1352.5366","46 Blank":"1638.8426","02 DMEM/F12 no adds":"3772.7321","45 DMEM/F12 no adds":"15866.3983","10 SUM159PT GSK 1 uM":"927.8556","13 SUM159PT GSK 1 uM":"7924.0608","09 SUM159PT DMM 5 mM":"3767.6988","12 SUM159PT DMM 5 mM":"5282.2980","11 SUM159PT Combination":"5884.2823","14 SUM159PT Combination":"1258.5442"},{"Metabolite":"3-Hydroxybutyric 17","40 CAL120 GSK 1 uM":"108.4150","43 CAL120 GSK 1 uM":"876.8556","39 CAL120 DMM 5 mM":"543.6598","42 CAL120 DMM 5 mM":"108.8059","41 CAL120 Combination":"325.2035","44 CAL120 Combination":"1089.5228","22 HCC1806 GSK 1 uM":"108.9933","25 HCC1806 GSK 1 uM":"1415.3526","21 HCC1806 DMM 5 mM":"764.1221","24 HCC1806 DMM 5 mM":"649.2345","23 HCC1806 Combination":"1198.6173","26 HCC1806 Combination":"704.5747","34 HS578T GSK 1 uM":"433.9262","37 HS578T GSK 1 uM":"216.4296","33 HS578T DMM 5 mM":"216.4812","36 HS578T DMM 5 mM":"216.0099","35 HS578T Combination":"106.3950","38 HS578T Combination":"107.3271","16 MCF7 GSK 1 uM":"323.6233","19 MCF7 GSK 1 uM":"441.7798","15 MCF7 DMM 5 mM":"759.8938","18 MCF7 DMM 5 mM":"1629.6996","17 MCF7 Combination":"330.6666","20 MCF7 Combination":"1520.0952","28 MDA-MB-231 GSK 1 uM":"982.3653","31 MDA-MB-231 GSK 1 uM":"867.8745","27 MDA-MB-231 DMM 5 mM":"1193.3832","30 MDA-MB-231 DMM 5 mM":"432.4640","29 MDA-MB-231 Combination":"215.5356","32 MDA-MB-231 Combination":"872.9435","04 MDA-MB-468 GSK 1 uM":"424.1698","07 MDA-MB-468 GSK 1 uM":"901.9343","03 MDA-MB-468 DMM 5 mM":"910.8786","06 MDA-MB-468 DMM 5 mM":"217.5011","05 MDA-MB-468 Combination":"4138.3027","08 MDA-MB-468 Combination":"535.3430","01 Blank":"638.4628","46 Blank":"315.9464","02 DMEM/F12 no adds":"424.7934","45 DMEM/F12 no adds":"213.3379","10 SUM159PT GSK 1 uM":"1194.1425","13 SUM159PT GSK 1 uM":"847.1006","09 SUM159PT DMM 5 mM":"606.9250","12 SUM159PT DMM 5 mM":"1197.1615","11 SUM159PT Combination":"812.5851","14 SUM159PT Combination":"864.0385"},{"Metabolite":"3-Hydroxybutyric 59","40 CAL120 GSK 1 uM":"57918.5177","43 CAL120 GSK 1 uM":"28568.5434","39 CAL120 DMM 5 mM":"22957.1974","42 CAL120 DMM 5 mM":"44972.9501","41 CAL120 Combination":"24211.1714","44 CAL120 Combination":"3128.2464","22 HCC1806 GSK 1 uM":"37136.7877","25 HCC1806 GSK 1 uM":"24560.0569","21 HCC1806 DMM 5 mM":"116858.5996","24 HCC1806 DMM 5 mM":"93666.2803","23 HCC1806 Combination":"133422.7431","26 HCC1806 Combination":"110570.6397","34 HS578T GSK 1 uM":"23750.9270","37 HS578T GSK 1 uM":"9304.7308","33 HS578T DMM 5 mM":"47954.4817","36 HS578T DMM 5 mM":"53920.1542","35 HS578T Combination":"73831.4505","38 HS578T Combination":"111421.6456","16 MCF7 GSK 1 uM":"114710.3688","19 MCF7 GSK 1 uM":"13511.7968","15 MCF7 DMM 5 mM":"79198.1594","18 MCF7 DMM 5 mM":"80166.1803","17 MCF7 Combination":"133294.3926","20 MCF7 Combination":"13893.0015","28 MDA-MB-231 GSK 1 uM":"90822.1050","31 MDA-MB-231 GSK 1 uM":"46411.9756","27 MDA-MB-231 DMM 5 mM":"8975.2105","30 MDA-MB-231 DMM 5 mM":"82324.2377","29 MDA-MB-231 Combination":"21147.8804","32 MDA-MB-231 Combination":"27218.8713","04 MDA-MB-468 GSK 1 uM":"50730.7884","07 MDA-MB-468 GSK 1 uM":"17644.6183","03 MDA-MB-468 DMM 5 mM":"158612.5473","06 MDA-MB-468 DMM 5 mM":"162815.7152","05 MDA-MB-468 Combination":"108160.9720","08 MDA-MB-468 Combination":"104320.5887","01 Blank":"17497.4443","46 Blank":"38471.3302","02 DMEM/F12 no adds":"48184.8069","45 DMEM/F12 no adds":"69163.1681","10 SUM159PT GSK 1 uM":"108166.0455","13 SUM159PT GSK 1 uM":"30216.5644","09 SUM159PT DMM 5 mM":"104952.3839","12 SUM159PT DMM 5 mM":"123052.5161","11 SUM159PT Combination":"183862.1996","14 SUM159PT Combination":"72672.9037"},{"Metabolite":"aCD 101","40 CAL120 GSK 1 uM":"","43 CAL120 GSK 1 uM":"","39 CAL120 DMM 5 mM":"","42 CAL120 DMM 5 mM":"","41 CAL120 Combination":"","44 CAL120 Combination":"","22 HCC1806 GSK 1 uM":"","25 HCC1806 GSK 1 uM":"","21 HCC1806 DMM 5 mM":"","24 HCC1806 DMM 5 mM":"","23 HCC1806 Combination":"","26 HCC1806 Combination":"","34 HS578T GSK 1 uM":"","37 HS578T GSK 1 uM":"","33 HS578T DMM 5 mM":"","36 HS578T DMM 5 mM":"","35 HS578T Combination":"","38 HS578T Combination":"","16 MCF7 GSK 1 uM":"","19 MCF7 GSK 1 uM":"","15 MCF7 DMM 5 mM":"","18 MCF7 DMM 5 mM":"","17 MCF7 Combination":"","20 MCF7 Combination":"","28 MDA-MB-231 GSK 1 uM":"","31 MDA-MB-231 GSK 1 uM":"","27 MDA-MB-231 DMM 5 mM":"","30 MDA-MB-231 DMM 5 mM":"","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"","04 MDA-MB-468 GSK 1 uM":"","07 MDA-MB-468 GSK 1 uM":"","03 MDA-MB-468 DMM 5 mM":"","06 MDA-MB-468 DMM 5 mM":"","05 MDA-MB-468 Combination":"","08 MDA-MB-468 Combination":"","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"","13 SUM159PT GSK 1 uM":"","09 SUM159PT DMM 5 mM":"","12 SUM159PT DMM 5 mM":"","11 SUM159PT Combination":"","14 SUM159PT Combination":""},{"Metabolite":"aCD 161","40 CAL120 GSK 1 uM":"269.4052","43 CAL120 GSK 1 uM":"1058.6283","39 CAL120 DMM 5 mM":"825.7620","42 CAL120 DMM 5 mM":"737.6316","41 CAL120 Combination":"595.1109","44 CAL120 Combination":"383.6693","22 HCC1806 GSK 1 uM":"451.4304","25 HCC1806 GSK 1 uM":"341.3720","21 HCC1806 DMM 5 mM":"","24 HCC1806 DMM 5 mM":"","23 HCC1806 Combination":"","26 HCC1806 Combination":"215.7398","34 HS578T GSK 1 uM":"950.7664","37 HS578T GSK 1 uM":"","33 HS578T DMM 5 mM":"","36 HS578T DMM 5 mM":"","35 HS578T Combination":"413.8956","38 HS578T Combination":"","16 MCF7 GSK 1 uM":"192.0371","19 MCF7 GSK 1 uM":"192.4948","15 MCF7 DMM 5 mM":"189.4731","18 MCF7 DMM 5 mM":"240.5981","17 MCF7 Combination":"","20 MCF7 Combination":"392.8727","28 MDA-MB-231 GSK 1 uM":"","31 MDA-MB-231 GSK 1 uM":"","27 MDA-MB-231 DMM 5 mM":"","30 MDA-MB-231 DMM 5 mM":"","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"774.2759","04 MDA-MB-468 GSK 1 uM":"229.2055","07 MDA-MB-468 GSK 1 uM":"188.7602","03 MDA-MB-468 DMM 5 mM":"","06 MDA-MB-468 DMM 5 mM":"210.7445","05 MDA-MB-468 Combination":"","08 MDA-MB-468 Combination":"194.9116","01 Blank":"345.5461","46 Blank":"329.5443","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"399.4782","13 SUM159PT GSK 1 uM":"213.2110","09 SUM159PT DMM 5 mM":"","12 SUM159PT DMM 5 mM":"461.3175","11 SUM159PT Combination":"","14 SUM159PT Combination":"701.3773"},{"Metabolite":"Acetic PAR","40 CAL120 GSK 1 uM":"2513865.0860","43 CAL120 GSK 1 uM":"2630373.7520","39 CAL120 DMM 5 mM":"631871.9755","42 CAL120 DMM 5 mM":"2082006.0310","41 CAL120 Combination":"4196317.8480","44 CAL120 Combination":"4910494.0840","22 HCC1806 GSK 1 uM":"1515351.1190","25 HCC1806 GSK 1 uM":"1418452.6130","21 HCC1806 DMM 5 mM":"970287.5452","24 HCC1806 DMM 5 mM":"1846241.4280","23 HCC1806 Combination":"1920482.1860","26 HCC1806 Combination":"1595877.2380","34 HS578T GSK 1 uM":"2216368.2990","37 HS578T GSK 1 uM":"1914762.1850","33 HS578T DMM 5 mM":"207700.1342","36 HS578T DMM 5 mM":"848457.3092","35 HS578T Combination":"1853806.6130","38 HS578T Combination":"4280108.2700","16 MCF7 GSK 1 uM":"2617297.4070","19 MCF7 GSK 1 uM":"939982.7872","15 MCF7 DMM 5 mM":"940593.5042","18 MCF7 DMM 5 mM":"1088667.9780","17 MCF7 Combination":"1311504.1270","20 MCF7 Combination":"2135261.3950","28 MDA-MB-231 GSK 1 uM":"1511887.2930","31 MDA-MB-231 GSK 1 uM":"1787450.0200","27 MDA-MB-231 DMM 5 mM":"1957271.3730","30 MDA-MB-231 DMM 5 mM":"912229.6386","29 MDA-MB-231 Combination":"1601835.4140","32 MDA-MB-231 Combination":"898438.4682","04 MDA-MB-468 GSK 1 uM":"1096699.4830","07 MDA-MB-468 GSK 1 uM":"1150778.0820","03 MDA-MB-468 DMM 5 mM":"921464.9535","06 MDA-MB-468 DMM 5 mM":"1097750.6090","05 MDA-MB-468 Combination":"591800.5012","08 MDA-MB-468 Combination":"1436413.1750","01 Blank":"1031669.8310","46 Blank":"5588244.3250","02 DMEM/F12 no adds":"4434310.8520","45 DMEM/F12 no adds":"5619465.8890","10 SUM159PT GSK 1 uM":"688651.0092","13 SUM159PT GSK 1 uM":"822360.0949","09 SUM159PT DMM 5 mM":"488663.9067","12 SUM159PT DMM 5 mM":"290442.5478","11 SUM159PT Combination":"505839.8501","14 SUM159PT Combination":"1021027.5350"},{"Metabolite":"Acetyl-CoA 408","40 CAL120 GSK 1 uM":"372097.3561","43 CAL120 GSK 1 uM":"367023.0554","39 CAL120 DMM 5 mM":"384926.3935","42 CAL120 DMM 5 mM":"366493.7750","41 CAL120 Combination":"362995.6957","44 CAL120 Combination":"418433.0110","22 HCC1806 GSK 1 uM":"468716.9920","25 HCC1806 GSK 1 uM":"430240.6702","21 HCC1806 DMM 5 mM":"348878.0637","24 HCC1806 DMM 5 mM":"357695.6854","23 HCC1806 Combination":"335874.9715","26 HCC1806 Combination":"336448.6795","34 HS578T GSK 1 uM":"119836.2997","37 HS578T GSK 1 uM":"137416.5035","33 HS578T DMM 5 mM":"142997.2156","36 HS578T DMM 5 mM":"133892.6024","35 HS578T Combination":"174390.1804","38 HS578T Combination":"167031.4554","16 MCF7 GSK 1 uM":"470504.7879","19 MCF7 GSK 1 uM":"557813.5353","15 MCF7 DMM 5 mM":"360396.9094","18 MCF7 DMM 5 mM":"337802.4292","17 MCF7 Combination":"666635.9789","20 MCF7 Combination":"356028.1392","28 MDA-MB-231 GSK 1 uM":"374481.0380","31 MDA-MB-231 GSK 1 uM":"425271.6992","27 MDA-MB-231 DMM 5 mM":"526329.6060","30 MDA-MB-231 DMM 5 mM":"473792.0951","29 MDA-MB-231 Combination":"317007.7056","32 MDA-MB-231 Combination":"393567.9794","04 MDA-MB-468 GSK 1 uM":"1121774.7350","07 MDA-MB-468 GSK 1 uM":"1260651.0080","03 MDA-MB-468 DMM 5 mM":"1165348.9010","06 MDA-MB-468 DMM 5 mM":"1101589.2950","05 MDA-MB-468 Combination":"1282383.5050","08 MDA-MB-468 Combination":"1167423.0970","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"128.7448","10 SUM159PT GSK 1 uM":"500829.9618","13 SUM159PT GSK 1 uM":"588639.4991","09 SUM159PT DMM 5 mM":"347726.4627","12 SUM159PT DMM 5 mM":"373139.6882","11 SUM159PT Combination":"364917.0236","14 SUM159PT Combination":"423555.0607"},{"Metabolite":"Acetyl-CoA 461","40 CAL120 GSK 1 uM":"274249.2611","43 CAL120 GSK 1 uM":"277185.5716","39 CAL120 DMM 5 mM":"279325.2661","42 CAL120 DMM 5 mM":"278794.1916","41 CAL120 Combination":"265742.2727","44 CAL120 Combination":"308695.9224","22 HCC1806 GSK 1 uM":"335950.6956","25 HCC1806 GSK 1 uM":"341653.9124","21 HCC1806 DMM 5 mM":"251775.9975","24 HCC1806 DMM 5 mM":"289163.9300","23 HCC1806 Combination":"253011.2547","26 HCC1806 Combination":"233870.6848","34 HS578T GSK 1 uM":"97625.3679","37 HS578T GSK 1 uM":"111284.3404","33 HS578T DMM 5 mM":"108589.5458","36 HS578T DMM 5 mM":"101908.4855","35 HS578T Combination":"151988.4539","38 HS578T Combination":"124765.8516","16 MCF7 GSK 1 uM":"362048.1494","19 MCF7 GSK 1 uM":"438120.1599","15 MCF7 DMM 5 mM":"277063.3562","18 MCF7 DMM 5 mM":"252233.2942","17 MCF7 Combination":"513125.9278","20 MCF7 Combination":"275025.4014","28 MDA-MB-231 GSK 1 uM":"280344.8023","31 MDA-MB-231 GSK 1 uM":"315948.7060","27 MDA-MB-231 DMM 5 mM":"388389.9972","30 MDA-MB-231 DMM 5 mM":"361185.5492","29 MDA-MB-231 Combination":"257981.7276","32 MDA-MB-231 Combination":"286753.3114","04 MDA-MB-468 GSK 1 uM":"879187.5517","07 MDA-MB-468 GSK 1 uM":"943276.0682","03 MDA-MB-468 DMM 5 mM":"872546.0449","06 MDA-MB-468 DMM 5 mM":"873238.9215","05 MDA-MB-468 Combination":"961391.8162","08 MDA-MB-468 Combination":"974009.7098","01 Blank":"98.8356","46 Blank":"278.0438","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"298.9516","10 SUM159PT GSK 1 uM":"344041.1768","13 SUM159PT GSK 1 uM":"442947.7653","09 SUM159PT DMM 5 mM":"266799.8271","12 SUM159PT DMM 5 mM":"269354.6632","11 SUM159PT Combination":"279280.5889","14 SUM159PT Combination":"324302.6351"},{"Metabolite":"Acetyl-CoA 79","40 CAL120 GSK 1 uM":"916284.9348","43 CAL120 GSK 1 uM":"970406.1160","39 CAL120 DMM 5 mM":"962670.1848","42 CAL120 DMM 5 mM":"899239.7981","41 CAL120 Combination":"903228.6519","44 CAL120 Combination":"1047216.2680","22 HCC1806 GSK 1 uM":"1109428.0960","25 HCC1806 GSK 1 uM":"1099021.6270","21 HCC1806 DMM 5 mM":"788037.8211","24 HCC1806 DMM 5 mM":"893244.8824","23 HCC1806 Combination":"805924.3163","26 HCC1806 Combination":"799482.7867","34 HS578T GSK 1 uM":"320027.4013","37 HS578T GSK 1 uM":"352077.3367","33 HS578T DMM 5 mM":"356814.9637","36 HS578T DMM 5 mM":"343013.7517","35 HS578T Combination":"487007.7909","38 HS578T Combination":"430809.6571","16 MCF7 GSK 1 uM":"1181834.2150","19 MCF7 GSK 1 uM":"1396464.5220","15 MCF7 DMM 5 mM":"933454.6910","18 MCF7 DMM 5 mM":"767363.7587","17 MCF7 Combination":"1751099.0800","20 MCF7 Combination":"887539.1124","28 MDA-MB-231 GSK 1 uM":"922604.1302","31 MDA-MB-231 GSK 1 uM":"1044797.1060","27 MDA-MB-231 DMM 5 mM":"1228000.3030","30 MDA-MB-231 DMM 5 mM":"1296694.7420","29 MDA-MB-231 Combination":"826297.3380","32 MDA-MB-231 Combination":"1034805.0320","04 MDA-MB-468 GSK 1 uM":"2875669.7180","07 MDA-MB-468 GSK 1 uM":"3171169.3470","03 MDA-MB-468 DMM 5 mM":"2937423.8830","06 MDA-MB-468 DMM 5 mM":"2916616.3860","05 MDA-MB-468 Combination":"3193068.3060","08 MDA-MB-468 Combination":"3031958.8120","01 Blank":"1001.1964","46 Blank":"2311.4356","02 DMEM/F12 no adds":"272.4015","45 DMEM/F12 no adds":"1679.6568","10 SUM159PT GSK 1 uM":"1135926.4640","13 SUM159PT GSK 1 uM":"1445025.4730","09 SUM159PT DMM 5 mM":"854776.0522","12 SUM159PT DMM 5 mM":"891373.9829","11 SUM159PT Combination":"919356.6955","14 SUM159PT Combination":"1055859.8860"},{"Metabolite":"Alanine NEG PAR","40 CAL120 GSK 1 uM":"7806725.3170","43 CAL120 GSK 1 uM":"9686789.3210","39 CAL120 DMM 5 mM":"7044174.4180","42 CAL120 DMM 5 mM":"17538543.3500","41 CAL120 Combination":"5636388.4850","44 CAL120 Combination":"6058697.7220","22 HCC1806 GSK 1 uM":"26806413.2600","25 HCC1806 GSK 1 uM":"20102483.5900","21 HCC1806 DMM 5 mM":"17106669.2500","24 HCC1806 DMM 5 mM":"18079545.5600","23 HCC1806 Combination":"16663599.1600","26 HCC1806 Combination":"15486937.2500","34 HS578T GSK 1 uM":"2049386.5070","37 HS578T GSK 1 uM":"2004332.2740","33 HS578T DMM 5 mM":"1270852.9470","36 HS578T DMM 5 mM":"1361847.1350","35 HS578T Combination":"1471384.3920","38 HS578T Combination":"1273451.8390","16 MCF7 GSK 1 uM":"5195208.3730","19 MCF7 GSK 1 uM":"6634741.9220","15 MCF7 DMM 5 mM":"6074936.1480","18 MCF7 DMM 5 mM":"5843354.1660","17 MCF7 Combination":"5548825.5120","20 MCF7 Combination":"3532696.6060","28 MDA-MB-231 GSK 1 uM":"1517595.9900","31 MDA-MB-231 GSK 1 uM":"1895561.8700","27 MDA-MB-231 DMM 5 mM":"2334430.7220","30 MDA-MB-231 DMM 5 mM":"2431289.8100","29 MDA-MB-231 Combination":"2277293.3340","32 MDA-MB-231 Combination":"2469278.4680","04 MDA-MB-468 GSK 1 uM":"40786235.9900","07 MDA-MB-468 GSK 1 uM":"40858668.0300","03 MDA-MB-468 DMM 5 mM":"40491620.8700","06 MDA-MB-468 DMM 5 mM":"37724885.8800","05 MDA-MB-468 Combination":"38352537.8300","08 MDA-MB-468 Combination":"37868313.7100","01 Blank":"2278.1673","46 Blank":"214415.5432","02 DMEM/F12 no adds":"1049799.2350","45 DMEM/F12 no adds":"1026484.3920","10 SUM159PT GSK 1 uM":"11809244.5900","13 SUM159PT GSK 1 uM":"16476627.3800","09 SUM159PT DMM 5 mM":"13044904.0400","12 SUM159PT DMM 5 mM":"12254929.2400","11 SUM159PT Combination":"10406409.3500","14 SUM159PT Combination":"10980432.2600"},{"Metabolite":"Arginine 131","40 CAL120 GSK 1 uM":"7903447.6290","43 CAL120 GSK 1 uM":"7335830.0320","39 CAL120 DMM 5 mM":"10749657.4100","42 CAL120 DMM 5 mM":"7347406.2560","41 CAL120 Combination":"7256965.8690","44 CAL120 Combination":"5569483.2330","22 HCC1806 GSK 1 uM":"29147693.4300","25 HCC1806 GSK 1 uM":"27960082.0700","21 HCC1806 DMM 5 mM":"33773505.3500","24 HCC1806 DMM 5 mM":"27340281.9200","23 HCC1806 Combination":"24746678.1900","26 HCC1806 Combination":"26961521.7900","34 HS578T GSK 1 uM":"6459029.6830","37 HS578T GSK 1 uM":"9541287.9180","33 HS578T DMM 5 mM":"7297491.5230","36 HS578T DMM 5 mM":"5802326.2060","35 HS578T Combination":"7853569.8250","38 HS578T Combination":"5146953.2700","16 MCF7 GSK 1 uM":"22639176.6800","19 MCF7 GSK 1 uM":"23787255.8800","15 MCF7 DMM 5 mM":"22724966.7600","18 MCF7 DMM 5 mM":"25786627.3800","17 MCF7 Combination":"20242922.2700","20 MCF7 Combination":"11770519.4000","28 MDA-MB-231 GSK 1 uM":"13478811.0500","31 MDA-MB-231 GSK 1 uM":"13335057.8400","27 MDA-MB-231 DMM 5 mM":"13482043.1800","30 MDA-MB-231 DMM 5 mM":"15365309.9200","29 MDA-MB-231 Combination":"12189476.5900","32 MDA-MB-231 Combination":"11415096.9600","04 MDA-MB-468 GSK 1 uM":"24657969.5300","07 MDA-MB-468 GSK 1 uM":"25541560.2900","03 MDA-MB-468 DMM 5 mM":"29814488.1300","06 MDA-MB-468 DMM 5 mM":"25795655.6000","05 MDA-MB-468 Combination":"20056565.6200","08 MDA-MB-468 Combination":"26454943.1700","01 Blank":"68842.9455","46 Blank":"80194.2166","02 DMEM/F12 no adds":"51082078.5000","45 DMEM/F12 no adds":"53067516.5800","10 SUM159PT GSK 1 uM":"12212359.2000","13 SUM159PT GSK 1 uM":"14102002.8700","09 SUM159PT DMM 5 mM":"11497193.8200","12 SUM159PT DMM 5 mM":"10329880.4800","11 SUM159PT Combination":"10951097.5600","14 SUM159PT Combination":"12265375.0500"},{"Metabolite":"Arginine 156","40 CAL120 GSK 1 uM":"489347.9799","43 CAL120 GSK 1 uM":"451257.1753","39 CAL120 DMM 5 mM":"654325.3011","42 CAL120 DMM 5 mM":"454977.1231","41 CAL120 Combination":"454262.0938","44 CAL120 Combination":"338783.1595","22 HCC1806 GSK 1 uM":"1784687.7450","25 HCC1806 GSK 1 uM":"1710175.2800","21 HCC1806 DMM 5 mM":"2075585.6630","24 HCC1806 DMM 5 mM":"1661150.8070","23 HCC1806 Combination":"1504023.3010","26 HCC1806 Combination":"1658477.0570","34 HS578T GSK 1 uM":"395925.7093","37 HS578T GSK 1 uM":"584655.2187","33 HS578T DMM 5 mM":"452235.2445","36 HS578T DMM 5 mM":"355187.4147","35 HS578T Combination":"485629.7524","38 HS578T Combination":"317001.0195","16 MCF7 GSK 1 uM":"1368321.0090","19 MCF7 GSK 1 uM":"1456304.2110","15 MCF7 DMM 5 mM":"1386205.8750","18 MCF7 DMM 5 mM":"1583403.8470","17 MCF7 Combination":"1238123.1670","20 MCF7 Combination":"718591.9102","28 MDA-MB-231 GSK 1 uM":"824915.2979","31 MDA-MB-231 GSK 1 uM":"812553.0371","27 MDA-MB-231 DMM 5 mM":"825590.9257","30 MDA-MB-231 DMM 5 mM":"945957.1372","29 MDA-MB-231 Combination":"749610.8661","32 MDA-MB-231 Combination":"698338.5677","04 MDA-MB-468 GSK 1 uM":"1513299.3990","07 MDA-MB-468 GSK 1 uM":"1572367.9570","03 MDA-MB-468 DMM 5 mM":"1787949.1080","06 MDA-MB-468 DMM 5 mM":"1567167.4560","05 MDA-MB-468 Combination":"1227653.6050","08 MDA-MB-468 Combination":"1642050.6830","01 Blank":"3945.9726","46 Blank":"6419.4628","02 DMEM/F12 no adds":"3117835.2150","45 DMEM/F12 no adds":"3240111.9530","10 SUM159PT GSK 1 uM":"756660.2016","13 SUM159PT GSK 1 uM":"863077.0403","09 SUM159PT DMM 5 mM":"708622.3809","12 SUM159PT DMM 5 mM":"631068.4682","11 SUM159PT Combination":"665287.5804","14 SUM159PT Combination":"752856.2895"},{"Metabolite":"Ascorbic 157","40 CAL120 GSK 1 uM":"612545.0250","43 CAL120 GSK 1 uM":"623247.0561","39 CAL120 DMM 5 mM":"658089.4852","42 CAL120 DMM 5 mM":"650326.7773","41 CAL120 Combination":"529446.7224","44 CAL120 Combination":"509725.6081","22 HCC1806 GSK 1 uM":"18326.7231","25 HCC1806 GSK 1 uM":"15752.3890","21 HCC1806 DMM 5 mM":"42092.6677","24 HCC1806 DMM 5 mM":"20675.6776","23 HCC1806 Combination":"9274.0282","26 HCC1806 Combination":"9926.0543","34 HS578T GSK 1 uM":"29639.4183","37 HS578T GSK 1 uM":"19254.1068","33 HS578T DMM 5 mM":"39707.6827","36 HS578T DMM 5 mM":"26674.4313","35 HS578T Combination":"33993.3404","38 HS578T Combination":"58291.1484","16 MCF7 GSK 1 uM":"158417.0906","19 MCF7 GSK 1 uM":"260763.5857","15 MCF7 DMM 5 mM":"325928.3677","18 MCF7 DMM 5 mM":"328425.5825","17 MCF7 Combination":"128282.0154","20 MCF7 Combination":"113421.8179","28 MDA-MB-231 GSK 1 uM":"42839.3570","31 MDA-MB-231 GSK 1 uM":"22998.6862","27 MDA-MB-231 DMM 5 mM":"49899.4440","30 MDA-MB-231 DMM 5 mM":"26934.4272","29 MDA-MB-231 Combination":"35864.2461","32 MDA-MB-231 Combination":"34439.5155","04 MDA-MB-468 GSK 1 uM":"32553.6315","07 MDA-MB-468 GSK 1 uM":"41142.4783","03 MDA-MB-468 DMM 5 mM":"77029.6531","06 MDA-MB-468 DMM 5 mM":"70981.2009","05 MDA-MB-468 Combination":"31308.7810","08 MDA-MB-468 Combination":"36392.4647","01 Blank":"23848.8535","46 Blank":"39391.9123","02 DMEM/F12 no adds":"64665.3040","45 DMEM/F12 no adds":"61194.1635","10 SUM159PT GSK 1 uM":"219912.0920","13 SUM159PT GSK 1 uM":"270141.8253","09 SUM159PT DMM 5 mM":"391646.9452","12 SUM159PT DMM 5 mM":"453708.1856","11 SUM159PT Combination":"250716.6184","14 SUM159PT Combination":"303740.1182"},{"Metabolite":"Ascorbic 79","40 CAL120 GSK 1 uM":"196838.7748","43 CAL120 GSK 1 uM":"36418.0049","39 CAL120 DMM 5 mM":"246837.4539","42 CAL120 DMM 5 mM":"255248.4634","41 CAL120 Combination":"119068.4698","44 CAL120 Combination":"169066.4047","22 HCC1806 GSK 1 uM":"128480.2057","25 HCC1806 GSK 1 uM":"374061.6833","21 HCC1806 DMM 5 mM":"382560.5618","24 HCC1806 DMM 5 mM":"160615.1652","23 HCC1806 Combination":"149577.2896","26 HCC1806 Combination":"100354.4829","34 HS578T GSK 1 uM":"209389.9500","37 HS578T GSK 1 uM":"287479.7670","33 HS578T DMM 5 mM":"526610.1049","36 HS578T DMM 5 mM":"319051.9084","35 HS578T Combination":"181712.6743","38 HS578T Combination":"355037.7163","16 MCF7 GSK 1 uM":"102796.4460","19 MCF7 GSK 1 uM":"97156.0406","15 MCF7 DMM 5 mM":"91624.8949","18 MCF7 DMM 5 mM":"203500.5777","17 MCF7 Combination":"230842.0396","20 MCF7 Combination":"76159.3646","28 MDA-MB-231 GSK 1 uM":"39261.8414","31 MDA-MB-231 GSK 1 uM":"227723.2496","27 MDA-MB-231 DMM 5 mM":"77742.1344","30 MDA-MB-231 DMM 5 mM":"211537.4928","29 MDA-MB-231 Combination":"284934.0711","32 MDA-MB-231 Combination":"143209.3611","04 MDA-MB-468 GSK 1 uM":"377055.0189","07 MDA-MB-468 GSK 1 uM":"185750.9445","03 MDA-MB-468 DMM 5 mM":"300702.2225","06 MDA-MB-468 DMM 5 mM":"232156.6820","05 MDA-MB-468 Combination":"323800.0959","08 MDA-MB-468 Combination":"201678.1631","01 Blank":"9243.1773","46 Blank":"29990.1288","02 DMEM/F12 no adds":"12981.1314","45 DMEM/F12 no adds":"34415.2910","10 SUM159PT GSK 1 uM":"210452.8597","13 SUM159PT GSK 1 uM":"298746.5347","09 SUM159PT DMM 5 mM":"375109.9267","12 SUM159PT DMM 5 mM":"174883.7485","11 SUM159PT Combination":"179778.6362","14 SUM159PT Combination":"361582.2964"},{"Metabolite":"Asparagine 113","40 CAL120 GSK 1 uM":"5319015.0350","43 CAL120 GSK 1 uM":"5344345.5000","39 CAL120 DMM 5 mM":"4865210.9380","42 CAL120 DMM 5 mM":"4314344.1620","41 CAL120 Combination":"3854891.0490","44 CAL120 Combination":"4248666.6490","22 HCC1806 GSK 1 uM":"11268038.6200","25 HCC1806 GSK 1 uM":"9409045.4860","21 HCC1806 DMM 5 mM":"10730757.3300","24 HCC1806 DMM 5 mM":"11342595.1400","23 HCC1806 Combination":"10812444.1700","26 HCC1806 Combination":"11008738.4200","34 HS578T GSK 1 uM":"6406655.7130","37 HS578T GSK 1 uM":"6002947.2510","33 HS578T DMM 5 mM":"5129013.8040","36 HS578T DMM 5 mM":"5242881.2400","35 HS578T Combination":"5282619.4220","38 HS578T Combination":"4558902.3890","16 MCF7 GSK 1 uM":"6325339.0830","19 MCF7 GSK 1 uM":"7807082.5540","15 MCF7 DMM 5 mM":"8348167.4640","18 MCF7 DMM 5 mM":"8320900.6760","17 MCF7 Combination":"6676010.4350","20 MCF7 Combination":"4772308.1090","28 MDA-MB-231 GSK 1 uM":"4993145.7360","31 MDA-MB-231 GSK 1 uM":"5356832.3710","27 MDA-MB-231 DMM 5 mM":"4224918.3880","30 MDA-MB-231 DMM 5 mM":"3974359.0420","29 MDA-MB-231 Combination":"4048784.5670","32 MDA-MB-231 Combination":"3969751.4180","04 MDA-MB-468 GSK 1 uM":"11797644.8000","07 MDA-MB-468 GSK 1 uM":"12233836.3200","03 MDA-MB-468 DMM 5 mM":"11107253.2600","06 MDA-MB-468 DMM 5 mM":"10478018.9400","05 MDA-MB-468 Combination":"10235742.8200","08 MDA-MB-468 Combination":"10632553.0100","01 Blank":"3466.2141","46 Blank":"14646.9277","02 DMEM/F12 no adds":"1710044.3860","45 DMEM/F12 no adds":"1671928.3090","10 SUM159PT GSK 1 uM":"3682229.2540","13 SUM159PT GSK 1 uM":"4748220.0310","09 SUM159PT DMM 5 mM":"3763829.0720","12 SUM159PT DMM 5 mM":"3518811.6370","11 SUM159PT Combination":"3467252.3370","14 SUM159PT Combination":"3659380.2370"},{"Metabolite":"Aspartic 115","40 CAL120 GSK 1 uM":"2988995.7930","43 CAL120 GSK 1 uM":"2695028.1390","39 CAL120 DMM 5 mM":"2417708.6920","42 CAL120 DMM 5 mM":"2198593.2260","41 CAL120 Combination":"1992594.3870","44 CAL120 Combination":"2043604.9540","22 HCC1806 GSK 1 uM":"4023909.2380","25 HCC1806 GSK 1 uM":"4525718.0800","21 HCC1806 DMM 5 mM":"5617923.3210","24 HCC1806 DMM 5 mM":"4619821.9250","23 HCC1806 Combination":"4307709.5580","26 HCC1806 Combination":"4593349.5180","34 HS578T GSK 1 uM":"1273752.6600","37 HS578T GSK 1 uM":"1962887.2390","33 HS578T DMM 5 mM":"1205656.2460","36 HS578T DMM 5 mM":"810802.3504","35 HS578T Combination":"1389087.8590","38 HS578T Combination":"722383.4300","16 MCF7 GSK 1 uM":"2276480.6320","19 MCF7 GSK 1 uM":"2524658.1590","15 MCF7 DMM 5 mM":"2467131.3880","18 MCF7 DMM 5 mM":"2716256.9270","17 MCF7 Combination":"1992479.3030","20 MCF7 Combination":"1786735.1780","28 MDA-MB-231 GSK 1 uM":"2154954.7830","31 MDA-MB-231 GSK 1 uM":"1969765.3440","27 MDA-MB-231 DMM 5 mM":"2076528.5700","30 MDA-MB-231 DMM 5 mM":"2264533.1490","29 MDA-MB-231 Combination":"1672797.4070","32 MDA-MB-231 Combination":"1392186.0670","04 MDA-MB-468 GSK 1 uM":"4064270.5680","07 MDA-MB-468 GSK 1 uM":"3940726.6870","03 MDA-MB-468 DMM 5 mM":"3312210.6780","06 MDA-MB-468 DMM 5 mM":"3245166.9270","05 MDA-MB-468 Combination":"3902886.9270","08 MDA-MB-468 Combination":"3708768.3510","01 Blank":"772.7356","46 Blank":"889.8872","02 DMEM/F12 no adds":"2408392.3470","45 DMEM/F12 no adds":"2511877.5010","10 SUM159PT GSK 1 uM":"1645047.4730","13 SUM159PT GSK 1 uM":"1902602.8450","09 SUM159PT DMM 5 mM":"2170620.8910","12 SUM159PT DMM 5 mM":"2050982.1110","11 SUM159PT Combination":"1961744.6460","14 SUM159PT Combination":"2221830.9320"},{"Metabolite":"Aspartic 88","40 CAL120 GSK 1 uM":"12321604.6400","43 CAL120 GSK 1 uM":"11283613.1400","39 CAL120 DMM 5 mM":"9781473.8190","42 CAL120 DMM 5 mM":"9155660.6400","41 CAL120 Combination":"8465860.6840","44 CAL120 Combination":"8770907.4820","22 HCC1806 GSK 1 uM":"17432885.9600","25 HCC1806 GSK 1 uM":"18598894.3800","21 HCC1806 DMM 5 mM":"23171749.1000","24 HCC1806 DMM 5 mM":"18509355.5000","23 HCC1806 Combination":"17500585.8700","26 HCC1806 Combination":"19713661.6800","34 HS578T GSK 1 uM":"4352335.2950","37 HS578T GSK 1 uM":"7145539.8530","33 HS578T DMM 5 mM":"4584936.1750","36 HS578T DMM 5 mM":"2631962.0730","35 HS578T Combination":"5613082.3400","38 HS578T Combination":"2379359.6270","16 MCF7 GSK 1 uM":"8936575.9980","19 MCF7 GSK 1 uM":"10174695.6100","15 MCF7 DMM 5 mM":"9740343.6070","18 MCF7 DMM 5 mM":"10842545.8900","17 MCF7 Combination":"7616573.7180","20 MCF7 Combination":"7005057.8170","28 MDA-MB-231 GSK 1 uM":"8718079.1750","31 MDA-MB-231 GSK 1 uM":"7196117.1630","27 MDA-MB-231 DMM 5 mM":"7527001.5900","30 MDA-MB-231 DMM 5 mM":"9553353.5300","29 MDA-MB-231 Combination":"6532725.1130","32 MDA-MB-231 Combination":"5841197.0290","04 MDA-MB-468 GSK 1 uM":"15732310.5400","07 MDA-MB-468 GSK 1 uM":"15954620.0300","03 MDA-MB-468 DMM 5 mM":"12779340.8700","06 MDA-MB-468 DMM 5 mM":"12979580.5800","05 MDA-MB-468 Combination":"15605016.4500","08 MDA-MB-468 Combination":"15715136.7900","01 Blank":"12459.4733","46 Blank":"7044.0480","02 DMEM/F12 no adds":"9551846.5280","45 DMEM/F12 no adds":"11471659.6200","10 SUM159PT GSK 1 uM":"6549352.8230","13 SUM159PT GSK 1 uM":"7479539.0640","09 SUM159PT DMM 5 mM":"9133176.3290","12 SUM159PT DMM 5 mM":"8604453.7050","11 SUM159PT Combination":"8018843.8910","14 SUM159PT Combination":"9155657.0110"},{"Metabolite":"Butyric PAR","40 CAL120 GSK 1 uM":"5445.8660","43 CAL120 GSK 1 uM":"5779.1710","39 CAL120 DMM 5 mM":"7366.7130","42 CAL120 DMM 5 mM":"4468.2430","41 CAL120 Combination":"34317.2395","44 CAL120 Combination":"7990.4285","22 HCC1806 GSK 1 uM":"2053377.0950","25 HCC1806 GSK 1 uM":"6777.8400","21 HCC1806 DMM 5 mM":"1655887.8440","24 HCC1806 DMM 5 mM":"10797.4135","23 HCC1806 Combination":"1239747.2970","26 HCC1806 Combination":"4375.2630","34 HS578T GSK 1 uM":"7198.8735","37 HS578T GSK 1 uM":"5209.2120","33 HS578T DMM 5 mM":"55279.0415","36 HS578T DMM 5 mM":"","35 HS578T Combination":"10633.3430","38 HS578T Combination":"56525.4525","16 MCF7 GSK 1 uM":"2564.9795","19 MCF7 GSK 1 uM":"9499.9225","15 MCF7 DMM 5 mM":"","18 MCF7 DMM 5 mM":"11022.9380","17 MCF7 Combination":"","20 MCF7 Combination":"13364.7460","28 MDA-MB-231 GSK 1 uM":"25465.0555","31 MDA-MB-231 GSK 1 uM":"44575.8319","27 MDA-MB-231 DMM 5 mM":"","30 MDA-MB-231 DMM 5 mM":"30346.5365","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"5988.1465","04 MDA-MB-468 GSK 1 uM":"2460335.2280","07 MDA-MB-468 GSK 1 uM":"19862.1170","03 MDA-MB-468 DMM 5 mM":"11356.6290","06 MDA-MB-468 DMM 5 mM":"6561.4790","05 MDA-MB-468 Combination":"28338.3714","08 MDA-MB-468 Combination":"","01 Blank":"41125.2582","46 Blank":"3574.1170","02 DMEM/F12 no adds":"2781201.7170","45 DMEM/F12 no adds":"2801209.8680","10 SUM159PT GSK 1 uM":"8661.0695","13 SUM159PT GSK 1 uM":"26216.4934","09 SUM159PT DMM 5 mM":"7541.3215","12 SUM159PT DMM 5 mM":"9510.0865","11 SUM159PT Combination":"4490.1120","14 SUM159PT Combination":"7567.0275"},{"Metabolite":"Butyryl-CoA 408","40 CAL120 GSK 1 uM":"491.9223","43 CAL120 GSK 1 uM":"541.4935","39 CAL120 DMM 5 mM":"15862.4092","42 CAL120 DMM 5 mM":"8018.0042","41 CAL120 Combination":"1680.1969","44 CAL120 Combination":"881.7754","22 HCC1806 GSK 1 uM":"242.8722","25 HCC1806 GSK 1 uM":"554.7735","21 HCC1806 DMM 5 mM":"2257.6361","24 HCC1806 DMM 5 mM":"4531.0458","23 HCC1806 Combination":"123.1249","26 HCC1806 Combination":"506.1273","34 HS578T GSK 1 uM":"478.9757","37 HS578T GSK 1 uM":"585.0356","33 HS578T DMM 5 mM":"3231.1921","36 HS578T DMM 5 mM":"3716.4488","35 HS578T Combination":"936.9304","38 HS578T Combination":"328.6088","16 MCF7 GSK 1 uM":"2347.9840","19 MCF7 GSK 1 uM":"8758.0540","15 MCF7 DMM 5 mM":"40810.1188","18 MCF7 DMM 5 mM":"37699.2461","17 MCF7 Combination":"4966.1153","20 MCF7 Combination":"1586.7739","28 MDA-MB-231 GSK 1 uM":"393.4586","31 MDA-MB-231 GSK 1 uM":"242.5661","27 MDA-MB-231 DMM 5 mM":"3745.7624","30 MDA-MB-231 DMM 5 mM":"4535.3461","29 MDA-MB-231 Combination":"156.6553","32 MDA-MB-231 Combination":"266.6707","04 MDA-MB-468 GSK 1 uM":"510.2357","07 MDA-MB-468 GSK 1 uM":"694.5443","03 MDA-MB-468 DMM 5 mM":"46268.0130","06 MDA-MB-468 DMM 5 mM":"47157.6800","05 MDA-MB-468 Combination":"861.1081","08 MDA-MB-468 Combination":"1608.0152","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"173.7632","10 SUM159PT GSK 1 uM":"815.4359","13 SUM159PT GSK 1 uM":"691.0483","09 SUM159PT DMM 5 mM":"5762.2136","12 SUM159PT DMM 5 mM":"11648.7764","11 SUM159PT Combination":"119.9428","14 SUM159PT Combination":"362.3693"},{"Metabolite":"Butyryl-CoA 79","40 CAL120 GSK 1 uM":"2085.4189","43 CAL120 GSK 1 uM":"2078.8388","39 CAL120 DMM 5 mM":"34958.8422","42 CAL120 DMM 5 mM":"16694.6204","41 CAL120 Combination":"3556.4942","44 CAL120 Combination":"4991.6118","22 HCC1806 GSK 1 uM":"6963.9688","25 HCC1806 GSK 1 uM":"3735.6728","21 HCC1806 DMM 5 mM":"12948.9980","24 HCC1806 DMM 5 mM":"20708.1074","23 HCC1806 Combination":"2418.2935","26 HCC1806 Combination":"2846.8589","34 HS578T GSK 1 uM":"9517.4446","37 HS578T GSK 1 uM":"5721.8664","33 HS578T DMM 5 mM":"4977.9701","36 HS578T DMM 5 mM":"14599.1586","35 HS578T Combination":"3339.2263","38 HS578T Combination":"4818.6972","16 MCF7 GSK 1 uM":"8827.0860","19 MCF7 GSK 1 uM":"20025.8397","15 MCF7 DMM 5 mM":"97611.7527","18 MCF7 DMM 5 mM":"87190.0369","17 MCF7 Combination":"24951.4502","20 MCF7 Combination":"5737.8204","28 MDA-MB-231 GSK 1 uM":"2366.7848","31 MDA-MB-231 GSK 1 uM":"1961.2900","27 MDA-MB-231 DMM 5 mM":"10232.9264","30 MDA-MB-231 DMM 5 mM":"11700.6393","29 MDA-MB-231 Combination":"2482.8433","32 MDA-MB-231 Combination":"4297.7124","04 MDA-MB-468 GSK 1 uM":"3884.3232","07 MDA-MB-468 GSK 1 uM":"2276.8124","03 MDA-MB-468 DMM 5 mM":"115433.8114","06 MDA-MB-468 DMM 5 mM":"110404.0852","05 MDA-MB-468 Combination":"1916.6741","08 MDA-MB-468 Combination":"3170.0714","01 Blank":"560.6806","46 Blank":"904.0643","02 DMEM/F12 no adds":"287.9001","45 DMEM/F12 no adds":"854.2631","10 SUM159PT GSK 1 uM":"3875.5670","13 SUM159PT GSK 1 uM":"2781.3582","09 SUM159PT DMM 5 mM":"16427.8071","12 SUM159PT DMM 5 mM":"31356.0641","11 SUM159PT Combination":"2287.6423","14 SUM159PT Combination":"6171.4841"},{"Metabolite":"C75 209","40 CAL120 GSK 1 uM":"11023.9617","43 CAL120 GSK 1 uM":"10562.3804","39 CAL120 DMM 5 mM":"43494.8463","42 CAL120 DMM 5 mM":"17056.5326","41 CAL120 Combination":"7567.8125","44 CAL120 Combination":"7882.9394","22 HCC1806 GSK 1 uM":"9577.5757","25 HCC1806 GSK 1 uM":"6008.3366","21 HCC1806 DMM 5 mM":"184785.7116","24 HCC1806 DMM 5 mM":"112089.0421","23 HCC1806 Combination":"22497.2355","26 HCC1806 Combination":"5715.8410","34 HS578T GSK 1 uM":"19124.8973","37 HS578T GSK 1 uM":"14184.9045","33 HS578T DMM 5 mM":"15796.5370","36 HS578T DMM 5 mM":"16994.8835","35 HS578T Combination":"15243.8699","38 HS578T Combination":"49261.0292","16 MCF7 GSK 1 uM":"9333.9867","19 MCF7 GSK 1 uM":"8932.6961","15 MCF7 DMM 5 mM":"77690.0571","18 MCF7 DMM 5 mM":"130212.1746","17 MCF7 Combination":"10503.7801","20 MCF7 Combination":"20165.0226","28 MDA-MB-231 GSK 1 uM":"10391.1365","31 MDA-MB-231 GSK 1 uM":"10804.1010","27 MDA-MB-231 DMM 5 mM":"30042.2967","30 MDA-MB-231 DMM 5 mM":"48929.4824","29 MDA-MB-231 Combination":"26760.7973","32 MDA-MB-231 Combination":"11123.3108","04 MDA-MB-468 GSK 1 uM":"10176.6967","07 MDA-MB-468 GSK 1 uM":"9540.1653","03 MDA-MB-468 DMM 5 mM":"299915.7544","06 MDA-MB-468 DMM 5 mM":"323858.1125","05 MDA-MB-468 Combination":"13806.2267","08 MDA-MB-468 Combination":"9444.2860","01 Blank":"5630.8291","46 Blank":"6407.8095","02 DMEM/F12 no adds":"6769.1562","45 DMEM/F12 no adds":"9360.2250","10 SUM159PT GSK 1 uM":"9305.0745","13 SUM159PT GSK 1 uM":"19312.2939","09 SUM159PT DMM 5 mM":"52291.7105","12 SUM159PT DMM 5 mM":"47624.2002","11 SUM159PT Combination":"7847.6205","14 SUM159PT Combination":"10690.6032"},{"Metabolite":"Cholic 343","40 CAL120 GSK 1 uM":"1135.7122","43 CAL120 GSK 1 uM":"831.8769","39 CAL120 DMM 5 mM":"1226.8290","42 CAL120 DMM 5 mM":"825.7126","41 CAL120 Combination":"2234.9602","44 CAL120 Combination":"1739.7167","22 HCC1806 GSK 1 uM":"1059.5103","25 HCC1806 GSK 1 uM":"1630.1521","21 HCC1806 DMM 5 mM":"705.0200","24 HCC1806 DMM 5 mM":"975.9153","23 HCC1806 Combination":"829.4032","26 HCC1806 Combination":"744.8351","34 HS578T GSK 1 uM":"362.7981","37 HS578T GSK 1 uM":"1854.9709","33 HS578T DMM 5 mM":"1630.0882","36 HS578T DMM 5 mM":"838.2535","35 HS578T Combination":"2173.1741","38 HS578T Combination":"509.0057","16 MCF7 GSK 1 uM":"359.1072","19 MCF7 GSK 1 uM":"677.5846","15 MCF7 DMM 5 mM":"948.2799","18 MCF7 DMM 5 mM":"377.2885","17 MCF7 Combination":"385.0033","20 MCF7 Combination":"409.2423","28 MDA-MB-231 GSK 1 uM":"480.2515","31 MDA-MB-231 GSK 1 uM":"1054.8097","27 MDA-MB-231 DMM 5 mM":"640.3291","30 MDA-MB-231 DMM 5 mM":"411.8335","29 MDA-MB-231 Combination":"625.0415","32 MDA-MB-231 Combination":"50974.3230","04 MDA-MB-468 GSK 1 uM":"369.7837","07 MDA-MB-468 GSK 1 uM":"523.7616","03 MDA-MB-468 DMM 5 mM":"616.9878","06 MDA-MB-468 DMM 5 mM":"923.4907","05 MDA-MB-468 Combination":"507.3632","08 MDA-MB-468 Combination":"243.7297","01 Blank":"452.4014","46 Blank":"243.2704","02 DMEM/F12 no adds":"477.2196","45 DMEM/F12 no adds":"992.0959","10 SUM159PT GSK 1 uM":"813.3817","13 SUM159PT GSK 1 uM":"844.4543","09 SUM159PT DMM 5 mM":"436.6197","12 SUM159PT DMM 5 mM":"719.5773","11 SUM159PT Combination":"1450.5077","14 SUM159PT Combination":"895.6671"},{"Metabolite":"Citraconic 85","40 CAL120 GSK 1 uM":"10894245.9800","43 CAL120 GSK 1 uM":"1305858.8720","39 CAL120 DMM 5 mM":"10716839.0900","42 CAL120 DMM 5 mM":"10622867.5900","41 CAL120 Combination":"1512578.9320","44 CAL120 Combination":"10745591.4100","22 HCC1806 GSK 1 uM":"7381150.4370","25 HCC1806 GSK 1 uM":"7410100.7910","21 HCC1806 DMM 5 mM":"6933934.7000","24 HCC1806 DMM 5 mM":"7943680.6170","23 HCC1806 Combination":"7706930.0210","26 HCC1806 Combination":"1212463.3650","34 HS578T GSK 1 uM":"12084549.5700","37 HS578T GSK 1 uM":"11853542.5400","33 HS578T DMM 5 mM":"11100455.9100","36 HS578T DMM 5 mM":"11674611.7400","35 HS578T Combination":"11363041.3200","38 HS578T Combination":"173052.3836","16 MCF7 GSK 1 uM":"3067456.2470","19 MCF7 GSK 1 uM":"3241998.6240","15 MCF7 DMM 5 mM":"2046216.2740","18 MCF7 DMM 5 mM":"1745825.8450","17 MCF7 Combination":"3100184.7680","20 MCF7 Combination":"3812682.1350","28 MDA-MB-231 GSK 1 uM":"5465578.4560","31 MDA-MB-231 GSK 1 uM":"5592089.4000","27 MDA-MB-231 DMM 5 mM":"5887116.0080","30 MDA-MB-231 DMM 5 mM":"5570979.6140","29 MDA-MB-231 Combination":"6108400.8410","32 MDA-MB-231 Combination":"855198.6568","04 MDA-MB-468 GSK 1 uM":"107281.9994","07 MDA-MB-468 GSK 1 uM":"74925.3047","03 MDA-MB-468 DMM 5 mM":"401884.4144","06 MDA-MB-468 DMM 5 mM":"377644.1981","05 MDA-MB-468 Combination":"375510.4471","08 MDA-MB-468 Combination":"419228.6311","01 Blank":"20663.5998","46 Blank":"15578.6509","02 DMEM/F12 no adds":"58978.1371","45 DMEM/F12 no adds":"69617.8687","10 SUM159PT GSK 1 uM":"6490563.5090","13 SUM159PT GSK 1 uM":"6475803.3340","09 SUM159PT DMM 5 mM":"5927098.3040","12 SUM159PT DMM 5 mM":"6355913.8420","11 SUM159PT Combination":"6991169.9640","14 SUM159PT Combination":"6813833.7340"},{"Metabolite":"Citric 111","40 CAL120 GSK 1 uM":"","43 CAL120 GSK 1 uM":"","39 CAL120 DMM 5 mM":"75455776.1800","42 CAL120 DMM 5 mM":"","41 CAL120 Combination":"","44 CAL120 Combination":"","22 HCC1806 GSK 1 uM":"","25 HCC1806 GSK 1 uM":"","21 HCC1806 DMM 5 mM":"","24 HCC1806 DMM 5 mM":"","23 HCC1806 Combination":"","26 HCC1806 Combination":"","34 HS578T GSK 1 uM":"","37 HS578T GSK 1 uM":"19690618.4800","33 HS578T DMM 5 mM":"16563368.8400","36 HS578T DMM 5 mM":"","35 HS578T Combination":"14451822.9100","38 HS578T Combination":"7103800.0990","16 MCF7 GSK 1 uM":"74159341.6700","19 MCF7 GSK 1 uM":"97642287.3500","15 MCF7 DMM 5 mM":"99095265.0900","18 MCF7 DMM 5 mM":"","17 MCF7 Combination":"","20 MCF7 Combination":"47667926.6500","28 MDA-MB-231 GSK 1 uM":"71803119.6600","31 MDA-MB-231 GSK 1 uM":"","27 MDA-MB-231 DMM 5 mM":"74008493.7900","30 MDA-MB-231 DMM 5 mM":"","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"","04 MDA-MB-468 GSK 1 uM":"104951857.6000","07 MDA-MB-468 GSK 1 uM":"","03 MDA-MB-468 DMM 5 mM":"82566130.4700","06 MDA-MB-468 DMM 5 mM":"","05 MDA-MB-468 Combination":"87228802.5400","08 MDA-MB-468 Combination":"","01 Blank":"2067.6095","46 Blank":"659630.2267","02 DMEM/F12 no adds":"2261.2411","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"76851423.3000","13 SUM159PT GSK 1 uM":"","09 SUM159PT DMM 5 mM":"100232902.6000","12 SUM159PT DMM 5 mM":"88005479.6400","11 SUM159PT Combination":"","14 SUM159PT Combination":"102746448.7000"},{"Metabolite":"Citric 173","40 CAL120 GSK 1 uM":"9620128.8400","43 CAL120 GSK 1 uM":"10007200.3900","39 CAL120 DMM 5 mM":"8271328.2940","42 CAL120 DMM 5 mM":"7207544.4370","41 CAL120 Combination":"8455141.3790","44 CAL120 Combination":"7684785.6580","22 HCC1806 GSK 1 uM":"18205101.6100","25 HCC1806 GSK 1 uM":"19053954.1500","21 HCC1806 DMM 5 mM":"15588180.9800","24 HCC1806 DMM 5 mM":"14924176.9900","23 HCC1806 Combination":"16235780.8300","26 HCC1806 Combination":"18587697.4100","34 HS578T GSK 1 uM":"1485007.3940","37 HS578T GSK 1 uM":"2051322.6190","33 HS578T DMM 5 mM":"1513238.9610","36 HS578T DMM 5 mM":"777079.6537","35 HS578T Combination":"1327309.2650","38 HS578T Combination":"798182.6299","16 MCF7 GSK 1 uM":"7564988.2810","19 MCF7 GSK 1 uM":"10462094.1700","15 MCF7 DMM 5 mM":"10439784.3100","18 MCF7 DMM 5 mM":"8554188.0520","17 MCF7 Combination":"10008098.7600","20 MCF7 Combination":"4235247.7250","28 MDA-MB-231 GSK 1 uM":"8031967.2790","31 MDA-MB-231 GSK 1 uM":"9287343.7910","27 MDA-MB-231 DMM 5 mM":"7789247.2520","30 MDA-MB-231 DMM 5 mM":"7709694.8590","29 MDA-MB-231 Combination":"6695037.4610","32 MDA-MB-231 Combination":"7543160.0540","04 MDA-MB-468 GSK 1 uM":"9480418.5010","07 MDA-MB-468 GSK 1 uM":"10549076.3100","03 MDA-MB-468 DMM 5 mM":"7988577.9150","06 MDA-MB-468 DMM 5 mM":"8115325.7520","05 MDA-MB-468 Combination":"8478191.2970","08 MDA-MB-468 Combination":"8511698.8960","01 Blank":"11135.6318","46 Blank":"37140.9526","02 DMEM/F12 no adds":"4304.5623","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"7988889.2930","13 SUM159PT GSK 1 uM":"9856323.2690","09 SUM159PT DMM 5 mM":"10782904.6700","12 SUM159PT DMM 5 mM":"9412279.6700","11 SUM159PT Combination":"8880485.0960","14 SUM159PT Combination":"11748301.1600"},{"Metabolite":"Citrulline 131","40 CAL120 GSK 1 uM":"112759.9249","43 CAL120 GSK 1 uM":"99544.9867","39 CAL120 DMM 5 mM":"90993.3601","42 CAL120 DMM 5 mM":"73811.8989","41 CAL120 Combination":"72304.8534","44 CAL120 Combination":"83549.0315","22 HCC1806 GSK 1 uM":"85281.7566","25 HCC1806 GSK 1 uM":"80299.7623","21 HCC1806 DMM 5 mM":"79730.0798","24 HCC1806 DMM 5 mM":"70794.2522","23 HCC1806 Combination":"131749.9809","26 HCC1806 Combination":"78896.7798","34 HS578T GSK 1 uM":"85756.5500","37 HS578T GSK 1 uM":"73272.7937","33 HS578T DMM 5 mM":"69535.5604","36 HS578T DMM 5 mM":"63326.4739","35 HS578T Combination":"75903.0085","38 HS578T Combination":"57662.4258","16 MCF7 GSK 1 uM":"42268.4229","19 MCF7 GSK 1 uM":"64671.2474","15 MCF7 DMM 5 mM":"35179.6389","18 MCF7 DMM 5 mM":"57483.3099","17 MCF7 Combination":"60925.5414","20 MCF7 Combination":"48552.8989","28 MDA-MB-231 GSK 1 uM":"48399.5566","31 MDA-MB-231 GSK 1 uM":"44957.8440","27 MDA-MB-231 DMM 5 mM":"54912.8180","30 MDA-MB-231 DMM 5 mM":"49557.6231","29 MDA-MB-231 Combination":"63324.3829","32 MDA-MB-231 Combination":"42209.2337","04 MDA-MB-468 GSK 1 uM":"94097.6776","07 MDA-MB-468 GSK 1 uM":"78946.5649","03 MDA-MB-468 DMM 5 mM":"77530.3821","06 MDA-MB-468 DMM 5 mM":"65771.3315","05 MDA-MB-468 Combination":"69247.6512","08 MDA-MB-468 Combination":"146424.8984","01 Blank":"622.6270","46 Blank":"2400.6717","02 DMEM/F12 no adds":"16887.0246","45 DMEM/F12 no adds":"15696.0076","10 SUM159PT GSK 1 uM":"33443.3588","13 SUM159PT GSK 1 uM":"37160.7532","09 SUM159PT DMM 5 mM":"45707.2079","12 SUM159PT DMM 5 mM":"37778.9492","11 SUM159PT Combination":"45014.8181","14 SUM159PT Combination":"34347.9413"},{"Metabolite":"Coenzyme A 408","40 CAL120 GSK 1 uM":"340814.4395","43 CAL120 GSK 1 uM":"326693.8374","39 CAL120 DMM 5 mM":"195977.1511","42 CAL120 DMM 5 mM":"186060.9736","41 CAL120 Combination":"294360.7538","44 CAL120 Combination":"339703.1518","22 HCC1806 GSK 1 uM":"453302.7291","25 HCC1806 GSK 1 uM":"466202.1967","21 HCC1806 DMM 5 mM":"265977.8699","24 HCC1806 DMM 5 mM":"245159.9912","23 HCC1806 Combination":"379224.6721","26 HCC1806 Combination":"362829.4706","34 HS578T GSK 1 uM":"99878.0863","37 HS578T GSK 1 uM":"116557.8771","33 HS578T DMM 5 mM":"63774.9849","36 HS578T DMM 5 mM":"56199.2753","35 HS578T Combination":"84851.4614","38 HS578T Combination":"58307.0256","16 MCF7 GSK 1 uM":"372725.0437","19 MCF7 GSK 1 uM":"380133.7809","15 MCF7 DMM 5 mM":"204243.4747","18 MCF7 DMM 5 mM":"218470.9478","17 MCF7 Combination":"395728.5923","20 MCF7 Combination":"289582.1730","28 MDA-MB-231 GSK 1 uM":"282047.1006","31 MDA-MB-231 GSK 1 uM":"264141.2095","27 MDA-MB-231 DMM 5 mM":"158162.8302","30 MDA-MB-231 DMM 5 mM":"179584.1943","29 MDA-MB-231 Combination":"166193.7511","32 MDA-MB-231 Combination":"225273.4244","04 MDA-MB-468 GSK 1 uM":"1041305.3090","07 MDA-MB-468 GSK 1 uM":"1061548.4970","03 MDA-MB-468 DMM 5 mM":"631013.5358","06 MDA-MB-468 DMM 5 mM":"620763.9058","05 MDA-MB-468 Combination":"889429.4293","08 MDA-MB-468 Combination":"870987.5421","01 Blank":"","46 Blank":"121.0329","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"881.6118","10 SUM159PT GSK 1 uM":"328481.0769","13 SUM159PT GSK 1 uM":"417017.6132","09 SUM159PT DMM 5 mM":"170713.5902","12 SUM159PT DMM 5 mM":"190360.7890","11 SUM159PT Combination":"245230.2656","14 SUM159PT Combination":"253608.9154"},{"Metabolite":"Coenzyme A 79","40 CAL120 GSK 1 uM":"1017099.8910","43 CAL120 GSK 1 uM":"842842.1608","39 CAL120 DMM 5 mM":"544606.2440","42 CAL120 DMM 5 mM":"476995.4972","41 CAL120 Combination":"779935.5714","44 CAL120 Combination":"893780.7598","22 HCC1806 GSK 1 uM":"1084084.0420","25 HCC1806 GSK 1 uM":"1305459.5970","21 HCC1806 DMM 5 mM":"666783.8135","24 HCC1806 DMM 5 mM":"720384.9565","23 HCC1806 Combination":"961351.4267","26 HCC1806 Combination":"1023434.3170","34 HS578T GSK 1 uM":"279147.5161","37 HS578T GSK 1 uM":"311579.6475","33 HS578T DMM 5 mM":"185179.0498","36 HS578T DMM 5 mM":"177281.8532","35 HS578T Combination":"222649.3522","38 HS578T Combination":"171656.9840","16 MCF7 GSK 1 uM":"999956.9399","19 MCF7 GSK 1 uM":"1121450.7090","15 MCF7 DMM 5 mM":"565342.7881","18 MCF7 DMM 5 mM":"536691.2562","17 MCF7 Combination":"1074784.7320","20 MCF7 Combination":"760749.2822","28 MDA-MB-231 GSK 1 uM":"790078.9015","31 MDA-MB-231 GSK 1 uM":"730264.3767","27 MDA-MB-231 DMM 5 mM":"474773.7329","30 MDA-MB-231 DMM 5 mM":"498231.3333","29 MDA-MB-231 Combination":"499838.7275","32 MDA-MB-231 Combination":"629823.7143","04 MDA-MB-468 GSK 1 uM":"2730344.7120","07 MDA-MB-468 GSK 1 uM":"2881862.8570","03 MDA-MB-468 DMM 5 mM":"1742493.9120","06 MDA-MB-468 DMM 5 mM":"1747817.4410","05 MDA-MB-468 Combination":"2303122.1450","08 MDA-MB-468 Combination":"2503352.6790","01 Blank":"590.5202","46 Blank":"2480.7401","02 DMEM/F12 no adds":"503.7401","45 DMEM/F12 no adds":"3292.1022","10 SUM159PT GSK 1 uM":"821772.8634","13 SUM159PT GSK 1 uM":"1142989.8380","09 SUM159PT DMM 5 mM":"458743.4145","12 SUM159PT DMM 5 mM":"458767.6064","11 SUM159PT Combination":"656190.0862","14 SUM159PT Combination":"731025.4995"},{"Metabolite":"Cysteine PAR","40 CAL120 GSK 1 uM":"19373.4616","43 CAL120 GSK 1 uM":"11338.5440","39 CAL120 DMM 5 mM":"6927.6348","42 CAL120 DMM 5 mM":"8110.1041","41 CAL120 Combination":"48024.9125","44 CAL120 Combination":"51574.9441","22 HCC1806 GSK 1 uM":"40414.6599","25 HCC1806 GSK 1 uM":"49238.3274","21 HCC1806 DMM 5 mM":"95790.2832","24 HCC1806 DMM 5 mM":"32982.6138","23 HCC1806 Combination":"81052.1288","26 HCC1806 Combination":"62329.3960","34 HS578T GSK 1 uM":"10613.5599","37 HS578T GSK 1 uM":"29393.9920","33 HS578T DMM 5 mM":"16092.0502","36 HS578T DMM 5 mM":"12942.9856","35 HS578T Combination":"9840.7661","38 HS578T Combination":"2212.4233","16 MCF7 GSK 1 uM":"78441.7647","19 MCF7 GSK 1 uM":"6891.4535","15 MCF7 DMM 5 mM":"2569.1037","18 MCF7 DMM 5 mM":"9246.0569","17 MCF7 Combination":"5508.0508","20 MCF7 Combination":"7541.3040","28 MDA-MB-231 GSK 1 uM":"29184.7161","31 MDA-MB-231 GSK 1 uM":"19452.8848","27 MDA-MB-231 DMM 5 mM":"3327.5023","30 MDA-MB-231 DMM 5 mM":"15554.7275","29 MDA-MB-231 Combination":"16301.3694","32 MDA-MB-231 Combination":"14494.5806","04 MDA-MB-468 GSK 1 uM":"36696.4861","07 MDA-MB-468 GSK 1 uM":"59389.9814","03 MDA-MB-468 DMM 5 mM":"26812.1898","06 MDA-MB-468 DMM 5 mM":"91891.4276","05 MDA-MB-468 Combination":"149831.2130","08 MDA-MB-468 Combination":"165053.5614","01 Blank":"10053.6268","46 Blank":"59666.1395","02 DMEM/F12 no adds":"530672.0318","45 DMEM/F12 no adds":"461588.9634","10 SUM159PT GSK 1 uM":"21734.7426","13 SUM159PT GSK 1 uM":"9943.9392","09 SUM159PT DMM 5 mM":"36406.8619","12 SUM159PT DMM 5 mM":"15524.3144","11 SUM159PT Combination":"6335.6432","14 SUM159PT Combination":"24240.4340"},{"Metabolite":"Cystine 120","40 CAL120 GSK 1 uM":"218497.1984","43 CAL120 GSK 1 uM":"393977.7347","39 CAL120 DMM 5 mM":"951810.0904","42 CAL120 DMM 5 mM":"232327.3590","41 CAL120 Combination":"189461.5184","44 CAL120 Combination":"181720.3509","22 HCC1806 GSK 1 uM":"298861.0588","25 HCC1806 GSK 1 uM":"127786.2446","21 HCC1806 DMM 5 mM":"238822.6718","24 HCC1806 DMM 5 mM":"394510.4859","23 HCC1806 Combination":"285651.0522","26 HCC1806 Combination":"174511.2777","34 HS578T GSK 1 uM":"206920.5552","37 HS578T GSK 1 uM":"403743.1486","33 HS578T DMM 5 mM":"353040.8531","36 HS578T DMM 5 mM":"290793.0357","35 HS578T Combination":"272625.3128","38 HS578T Combination":"256908.3685","16 MCF7 GSK 1 uM":"874599.2036","19 MCF7 GSK 1 uM":"324537.1488","15 MCF7 DMM 5 mM":"575560.6330","18 MCF7 DMM 5 mM":"949167.7219","17 MCF7 Combination":"449954.1483","20 MCF7 Combination":"284565.1151","28 MDA-MB-231 GSK 1 uM":"272988.0335","31 MDA-MB-231 GSK 1 uM":"533457.8238","27 MDA-MB-231 DMM 5 mM":"348002.2980","30 MDA-MB-231 DMM 5 mM":"281166.9880","29 MDA-MB-231 Combination":"552127.2788","32 MDA-MB-231 Combination":"312039.4563","04 MDA-MB-468 GSK 1 uM":"714830.1361","07 MDA-MB-468 GSK 1 uM":"735662.0625","03 MDA-MB-468 DMM 5 mM":"2886167.0650","06 MDA-MB-468 DMM 5 mM":"654083.9758","05 MDA-MB-468 Combination":"1510118.2660","08 MDA-MB-468 Combination":"666668.1225","01 Blank":"6989.7728","46 Blank":"7128.6873","02 DMEM/F12 no adds":"4331678.1030","45 DMEM/F12 no adds":"5268811.7710","10 SUM159PT GSK 1 uM":"176095.2029","13 SUM159PT GSK 1 uM":"164951.8710","09 SUM159PT DMM 5 mM":"234808.9889","12 SUM159PT DMM 5 mM":"95780.7284","11 SUM159PT Combination":"160935.5715","14 SUM159PT Combination":"199381.9053"},{"Metabolite":"Cystine 74","40 CAL120 GSK 1 uM":"74042.2215","43 CAL120 GSK 1 uM":"119084.6628","39 CAL120 DMM 5 mM":"286308.5379","42 CAL120 DMM 5 mM":"88743.1740","41 CAL120 Combination":"63920.7048","44 CAL120 Combination":"56876.1626","22 HCC1806 GSK 1 uM":"54533.9865","25 HCC1806 GSK 1 uM":"33934.4120","21 HCC1806 DMM 5 mM":"82319.8164","24 HCC1806 DMM 5 mM":"117153.0993","23 HCC1806 Combination":"69558.2485","26 HCC1806 Combination":"59684.1800","34 HS578T GSK 1 uM":"73368.8972","37 HS578T GSK 1 uM":"122657.4825","33 HS578T DMM 5 mM":"113891.5373","36 HS578T DMM 5 mM":"84089.0711","35 HS578T Combination":"91667.1855","38 HS578T Combination":"81856.5054","16 MCF7 GSK 1 uM":"265488.7457","19 MCF7 GSK 1 uM":"109770.7811","15 MCF7 DMM 5 mM":"166374.3569","18 MCF7 DMM 5 mM":"300661.5976","17 MCF7 Combination":"128766.6278","20 MCF7 Combination":"78794.1628","28 MDA-MB-231 GSK 1 uM":"94286.0137","31 MDA-MB-231 GSK 1 uM":"150058.7317","27 MDA-MB-231 DMM 5 mM":"98751.0001","30 MDA-MB-231 DMM 5 mM":"77874.1399","29 MDA-MB-231 Combination":"154862.2554","32 MDA-MB-231 Combination":"85841.7053","04 MDA-MB-468 GSK 1 uM":"208515.2498","07 MDA-MB-468 GSK 1 uM":"208346.7696","03 MDA-MB-468 DMM 5 mM":"870390.5269","06 MDA-MB-468 DMM 5 mM":"207116.6875","05 MDA-MB-468 Combination":"424629.3206","08 MDA-MB-468 Combination":"176908.9236","01 Blank":"2196.3115","46 Blank":"1440.8409","02 DMEM/F12 no adds":"1231793.4040","45 DMEM/F12 no adds":"1529121.4330","10 SUM159PT GSK 1 uM":"32617.8717","13 SUM159PT GSK 1 uM":"43811.3702","09 SUM159PT DMM 5 mM":"64643.8853","12 SUM159PT DMM 5 mM":"47230.4349","11 SUM159PT Combination":"59785.1425","14 SUM159PT Combination":"61882.0180"},{"Metabolite":"FAD 408","40 CAL120 GSK 1 uM":"45140.6761","43 CAL120 GSK 1 uM":"27895.6978","39 CAL120 DMM 5 mM":"48574.6224","42 CAL120 DMM 5 mM":"46013.9444","41 CAL120 Combination":"41931.1395","44 CAL120 Combination":"59449.6351","22 HCC1806 GSK 1 uM":"108600.9363","25 HCC1806 GSK 1 uM":"104771.1832","21 HCC1806 DMM 5 mM":"94648.6109","24 HCC1806 DMM 5 mM":"90849.0476","23 HCC1806 Combination":"99990.4363","26 HCC1806 Combination":"100447.9221","34 HS578T GSK 1 uM":"18132.0285","37 HS578T GSK 1 uM":"38071.6223","33 HS578T DMM 5 mM":"34683.9124","36 HS578T DMM 5 mM":"33742.8518","35 HS578T Combination":"42932.2981","38 HS578T Combination":"36813.6438","16 MCF7 GSK 1 uM":"51871.4963","19 MCF7 GSK 1 uM":"55564.3106","15 MCF7 DMM 5 mM":"50604.2550","18 MCF7 DMM 5 mM":"49946.4401","17 MCF7 Combination":"58742.7180","20 MCF7 Combination":"37567.3693","28 MDA-MB-231 GSK 1 uM":"40695.1412","31 MDA-MB-231 GSK 1 uM":"44402.9437","27 MDA-MB-231 DMM 5 mM":"36625.9424","30 MDA-MB-231 DMM 5 mM":"23371.2045","29 MDA-MB-231 Combination":"40542.5830","32 MDA-MB-231 Combination":"38562.3992","04 MDA-MB-468 GSK 1 uM":"162927.8243","07 MDA-MB-468 GSK 1 uM":"156781.5113","03 MDA-MB-468 DMM 5 mM":"163652.3986","06 MDA-MB-468 DMM 5 mM":"171867.1323","05 MDA-MB-468 Combination":"158201.8073","08 MDA-MB-468 Combination":"155456.5017","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"128.2169","10 SUM159PT GSK 1 uM":"98413.3962","13 SUM159PT GSK 1 uM":"126512.6508","09 SUM159PT DMM 5 mM":"137457.5724","12 SUM159PT DMM 5 mM":"132066.8949","11 SUM159PT Combination":"131800.8621","14 SUM159PT Combination":"148591.8740"},{"Metabolite":"FAD 79","40 CAL120 GSK 1 uM":"639997.5548","43 CAL120 GSK 1 uM":"696116.3286","39 CAL120 DMM 5 mM":"693772.3644","42 CAL120 DMM 5 mM":"655676.4803","41 CAL120 Combination":"643437.2073","44 CAL120 Combination":"826596.6092","22 HCC1806 GSK 1 uM":"1477093.9260","25 HCC1806 GSK 1 uM":"1564217.3200","21 HCC1806 DMM 5 mM":"1410378.0030","24 HCC1806 DMM 5 mM":"1364983.5200","23 HCC1806 Combination":"1361167.8870","26 HCC1806 Combination":"1364785.0350","34 HS578T GSK 1 uM":"475804.4537","37 HS578T GSK 1 uM":"528006.5082","33 HS578T DMM 5 mM":"488937.5814","36 HS578T DMM 5 mM":"505038.3280","35 HS578T Combination":"656773.5034","38 HS578T Combination":"537728.7521","16 MCF7 GSK 1 uM":"707489.3575","19 MCF7 GSK 1 uM":"777022.3525","15 MCF7 DMM 5 mM":"767782.4715","18 MCF7 DMM 5 mM":"700777.2387","17 MCF7 Combination":"869804.9706","20 MCF7 Combination":"534580.2217","28 MDA-MB-231 GSK 1 uM":"550237.4325","31 MDA-MB-231 GSK 1 uM":"580256.0356","27 MDA-MB-231 DMM 5 mM":"555093.3191","30 MDA-MB-231 DMM 5 mM":"541653.9643","29 MDA-MB-231 Combination":"509657.5401","32 MDA-MB-231 Combination":"586925.9673","04 MDA-MB-468 GSK 1 uM":"2468764.9190","07 MDA-MB-468 GSK 1 uM":"2338024.8520","03 MDA-MB-468 DMM 5 mM":"2494797.5990","06 MDA-MB-468 DMM 5 mM":"2336133.0800","05 MDA-MB-468 Combination":"2138955.3320","08 MDA-MB-468 Combination":"2299374.6300","01 Blank":"963.9715","46 Blank":"1741.8322","02 DMEM/F12 no adds":"374.0836","45 DMEM/F12 no adds":"1712.5156","10 SUM159PT GSK 1 uM":"1474998.5030","13 SUM159PT GSK 1 uM":"1771716.2120","09 SUM159PT DMM 5 mM":"1884109.1560","12 SUM159PT DMM 5 mM":"1846242.1980","11 SUM159PT Combination":"1779800.0150","14 SUM159PT Combination":"2077412.1230"},{"Metabolite":"Folic 311","40 CAL120 GSK 1 uM":"24354.9370","43 CAL120 GSK 1 uM":"22328.4278","39 CAL120 DMM 5 mM":"54533.3505","42 CAL120 DMM 5 mM":"29584.1106","41 CAL120 Combination":"30823.7309","44 CAL120 Combination":"13893.4256","22 HCC1806 GSK 1 uM":"73220.2756","25 HCC1806 GSK 1 uM":"46635.2864","21 HCC1806 DMM 5 mM":"110601.9385","24 HCC1806 DMM 5 mM":"50909.5958","23 HCC1806 Combination":"35955.6925","26 HCC1806 Combination":"43479.7738","34 HS578T GSK 1 uM":"13156.0357","37 HS578T GSK 1 uM":"48043.2462","33 HS578T DMM 5 mM":"38770.1595","36 HS578T DMM 5 mM":"22900.4135","35 HS578T Combination":"33702.7139","38 HS578T Combination":"23171.7119","16 MCF7 GSK 1 uM":"42345.2516","19 MCF7 GSK 1 uM":"32930.1189","15 MCF7 DMM 5 mM":"43124.0503","18 MCF7 DMM 5 mM":"86050.3049","17 MCF7 Combination":"35750.8699","20 MCF7 Combination":"25386.4810","28 MDA-MB-231 GSK 1 uM":"54428.5154","31 MDA-MB-231 GSK 1 uM":"40788.6453","27 MDA-MB-231 DMM 5 mM":"56358.9225","30 MDA-MB-231 DMM 5 mM":"65876.4269","29 MDA-MB-231 Combination":"32542.9309","32 MDA-MB-231 Combination":"27092.1412","04 MDA-MB-468 GSK 1 uM":"142550.0131","07 MDA-MB-468 GSK 1 uM":"192972.2943","03 MDA-MB-468 DMM 5 mM":"210161.6366","06 MDA-MB-468 DMM 5 mM":"168379.5485","05 MDA-MB-468 Combination":"86912.5678","08 MDA-MB-468 Combination":"177958.7690","01 Blank":"1649.2684","46 Blank":"1117.8615","02 DMEM/F12 no adds":"1440822.4250","45 DMEM/F12 no adds":"1624562.8820","10 SUM159PT GSK 1 uM":"26508.1491","13 SUM159PT GSK 1 uM":"23305.3248","09 SUM159PT DMM 5 mM":"29061.5500","12 SUM159PT DMM 5 mM":"20124.8102","11 SUM159PT Combination":"19258.6711","14 SUM159PT Combination":"19198.7405"},{"Metabolite":"Formic PAR","40 CAL120 GSK 1 uM":"1290171.5430","43 CAL120 GSK 1 uM":"3049831.0080","39 CAL120 DMM 5 mM":"2474612.2690","42 CAL120 DMM 5 mM":"2767726.4740","41 CAL120 Combination":"880871.6015","44 CAL120 Combination":"9070529.0650","22 HCC1806 GSK 1 uM":"2415016.3520","25 HCC1806 GSK 1 uM":"2565904.3040","21 HCC1806 DMM 5 mM":"1092988.4350","24 HCC1806 DMM 5 mM":"4611568.1510","23 HCC1806 Combination":"1983368.8460","26 HCC1806 Combination":"922323.3150","34 HS578T GSK 1 uM":"1084404.7340","37 HS578T GSK 1 uM":"902373.5115","33 HS578T DMM 5 mM":"2264712.8410","36 HS578T DMM 5 mM":"1942896.4420","35 HS578T Combination":"3230439.2780","38 HS578T Combination":"957452.8440","16 MCF7 GSK 1 uM":"1075265.4370","19 MCF7 GSK 1 uM":"1505045.7120","15 MCF7 DMM 5 mM":"564855.0550","18 MCF7 DMM 5 mM":"1772865.5870","17 MCF7 Combination":"1452801.9340","20 MCF7 Combination":"2872861.3910","28 MDA-MB-231 GSK 1 uM":"849495.1690","31 MDA-MB-231 GSK 1 uM":"3097446.4650","27 MDA-MB-231 DMM 5 mM":"1288834.8070","30 MDA-MB-231 DMM 5 mM":"1719077.0910","29 MDA-MB-231 Combination":"2465820.6300","32 MDA-MB-231 Combination":"1251181.3670","04 MDA-MB-468 GSK 1 uM":"2055375.2640","07 MDA-MB-468 GSK 1 uM":"2291078.4060","03 MDA-MB-468 DMM 5 mM":"1171372.7070","06 MDA-MB-468 DMM 5 mM":"1785382.3450","05 MDA-MB-468 Combination":"4078947.3770","08 MDA-MB-468 Combination":"1545631.2410","01 Blank":"1697686.6500","46 Blank":"7466501.7220","02 DMEM/F12 no adds":"1234140.6940","45 DMEM/F12 no adds":"891166.5010","10 SUM159PT GSK 1 uM":"2479487.4850","13 SUM159PT GSK 1 uM":"918291.0130","09 SUM159PT DMM 5 mM":"4013339.4930","12 SUM159PT DMM 5 mM":"2388909.8450","11 SUM159PT Combination":"1418090.8380","14 SUM159PT Combination":"2182064.7540"},{"Metabolite":"Formyl-CoA 408","40 CAL120 GSK 1 uM":"","43 CAL120 GSK 1 uM":"878.3650","39 CAL120 DMM 5 mM":"592.4410","42 CAL120 DMM 5 mM":"323.0705","41 CAL120 Combination":"144.0795","44 CAL120 Combination":"","22 HCC1806 GSK 1 uM":"485.3828","25 HCC1806 GSK 1 uM":"392.0013","21 HCC1806 DMM 5 mM":"512.0613","24 HCC1806 DMM 5 mM":"1321.9824","23 HCC1806 Combination":"340.2478","26 HCC1806 Combination":"1679.3703","34 HS578T GSK 1 uM":"269.4115","37 HS578T GSK 1 uM":"","33 HS578T DMM 5 mM":"141.1329","36 HS578T DMM 5 mM":"131.5987","35 HS578T Combination":"192.3919","38 HS578T Combination":"376.7457","16 MCF7 GSK 1 uM":"148.0569","19 MCF7 GSK 1 uM":"172.1442","15 MCF7 DMM 5 mM":"482.5892","18 MCF7 DMM 5 mM":"","17 MCF7 Combination":"130.0422","20 MCF7 Combination":"239.6807","28 MDA-MB-231 GSK 1 uM":"529.0489","31 MDA-MB-231 GSK 1 uM":"796.1801","27 MDA-MB-231 DMM 5 mM":"296.9893","30 MDA-MB-231 DMM 5 mM":"","29 MDA-MB-231 Combination":"314.3262","32 MDA-MB-231 Combination":"538.5830","04 MDA-MB-468 GSK 1 uM":"810.4738","07 MDA-MB-468 GSK 1 uM":"197.3858","03 MDA-MB-468 DMM 5 mM":"192.8285","06 MDA-MB-468 DMM 5 mM":"488.8540","05 MDA-MB-468 Combination":"1004.9846","08 MDA-MB-468 Combination":"211.7801","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"235.2963","45 DMEM/F12 no adds":"125.6137","10 SUM159PT GSK 1 uM":"967.1706","13 SUM159PT GSK 1 uM":"1214.4668","09 SUM159PT DMM 5 mM":"968.4626","12 SUM159PT DMM 5 mM":"647.7478","11 SUM159PT Combination":"166.2098","14 SUM159PT Combination":"190.8494"},{"Metabolite":"Formyl-CoA 79","40 CAL120 GSK 1 uM":"6300.2874","43 CAL120 GSK 1 uM":"4534.2013","39 CAL120 DMM 5 mM":"5700.6612","42 CAL120 DMM 5 mM":"7194.5269","41 CAL120 Combination":"1583.0331","44 CAL120 Combination":"8687.6982","22 HCC1806 GSK 1 uM":"5521.7613","25 HCC1806 GSK 1 uM":"3058.7057","21 HCC1806 DMM 5 mM":"9028.8097","24 HCC1806 DMM 5 mM":"5584.8879","23 HCC1806 Combination":"9900.4243","26 HCC1806 Combination":"11703.9448","34 HS578T GSK 1 uM":"2703.5825","37 HS578T GSK 1 uM":"4572.9118","33 HS578T DMM 5 mM":"1949.9741","36 HS578T DMM 5 mM":"2898.9379","35 HS578T Combination":"3059.9620","38 HS578T Combination":"3835.7917","16 MCF7 GSK 1 uM":"6149.1504","19 MCF7 GSK 1 uM":"7570.6423","15 MCF7 DMM 5 mM":"2973.1814","18 MCF7 DMM 5 mM":"8486.8528","17 MCF7 Combination":"3536.6979","20 MCF7 Combination":"7633.3548","28 MDA-MB-231 GSK 1 uM":"4985.7272","31 MDA-MB-231 GSK 1 uM":"4463.1613","27 MDA-MB-231 DMM 5 mM":"2431.6640","30 MDA-MB-231 DMM 5 mM":"2872.6959","29 MDA-MB-231 Combination":"2409.4577","32 MDA-MB-231 Combination":"4587.3787","04 MDA-MB-468 GSK 1 uM":"3591.3708","07 MDA-MB-468 GSK 1 uM":"3978.2048","03 MDA-MB-468 DMM 5 mM":"3667.2821","06 MDA-MB-468 DMM 5 mM":"5872.6086","05 MDA-MB-468 Combination":"5024.8871","08 MDA-MB-468 Combination":"1728.9129","01 Blank":"552.2303","46 Blank":"1203.7146","02 DMEM/F12 no adds":"628.2940","45 DMEM/F12 no adds":"1943.3993","10 SUM159PT GSK 1 uM":"8447.3688","13 SUM159PT GSK 1 uM":"13935.7520","09 SUM159PT DMM 5 mM":"10067.6804","12 SUM159PT DMM 5 mM":"8166.3515","11 SUM159PT Combination":"7780.5669","14 SUM159PT Combination":"10221.7697"},{"Metabolite":"Fructose-1_6-bisphosphate 177","40 CAL120 GSK 1 uM":"784.3954","43 CAL120 GSK 1 uM":"599.8423","39 CAL120 DMM 5 mM":"1574.0225","42 CAL120 DMM 5 mM":"596.5776","41 CAL120 Combination":"511.8001","44 CAL120 Combination":"138.5910","22 HCC1806 GSK 1 uM":"11017.7424","25 HCC1806 GSK 1 uM":"6321.4000","21 HCC1806 DMM 5 mM":"2190.2934","24 HCC1806 DMM 5 mM":"2821.7390","23 HCC1806 Combination":"2845.0438","26 HCC1806 Combination":"3867.5612","34 HS578T GSK 1 uM":"3359.3358","37 HS578T GSK 1 uM":"3777.1821","33 HS578T DMM 5 mM":"1130.8521","36 HS578T DMM 5 mM":"3884.9033","35 HS578T Combination":"5212.0624","38 HS578T Combination":"4332.2567","16 MCF7 GSK 1 uM":"213.8068","19 MCF7 GSK 1 uM":"376.4015","15 MCF7 DMM 5 mM":"343.2377","18 MCF7 DMM 5 mM":"","17 MCF7 Combination":"","20 MCF7 Combination":"266.6994","28 MDA-MB-231 GSK 1 uM":"5829.6576","31 MDA-MB-231 GSK 1 uM":"989.3325","27 MDA-MB-231 DMM 5 mM":"3557.4597","30 MDA-MB-231 DMM 5 mM":"2148.9301","29 MDA-MB-231 Combination":"2178.0039","32 MDA-MB-231 Combination":"2646.1087","04 MDA-MB-468 GSK 1 uM":"8785.0774","07 MDA-MB-468 GSK 1 uM":"17767.3599","03 MDA-MB-468 DMM 5 mM":"5043.9827","06 MDA-MB-468 DMM 5 mM":"2126.8135","05 MDA-MB-468 Combination":"6165.4412","08 MDA-MB-468 Combination":"8698.6122","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"6656.8705","13 SUM159PT GSK 1 uM":"12563.5649","09 SUM159PT DMM 5 mM":"421.4437","12 SUM159PT DMM 5 mM":"1093.4447","11 SUM159PT Combination":"582.9955","14 SUM159PT Combination":"375.1572"},{"Metabolite":"Fructose-1_6-bisphosphate 97","40 CAL120 GSK 1 uM":"247847.7776","43 CAL120 GSK 1 uM":"164626.0783","39 CAL120 DMM 5 mM":"41883.1902","42 CAL120 DMM 5 mM":"30168.9521","41 CAL120 Combination":"38840.8254","44 CAL120 Combination":"32947.0559","22 HCC1806 GSK 1 uM":"2263477.1070","25 HCC1806 GSK 1 uM":"2399130.7840","21 HCC1806 DMM 5 mM":"829320.3568","24 HCC1806 DMM 5 mM":"666927.1544","23 HCC1806 Combination":"749102.8927","26 HCC1806 Combination":"840023.4668","34 HS578T GSK 1 uM":"419902.8753","37 HS578T GSK 1 uM":"570259.2583","33 HS578T DMM 5 mM":"218719.9440","36 HS578T DMM 5 mM":"225841.1729","35 HS578T Combination":"646536.4302","38 HS578T Combination":"345580.3834","16 MCF7 GSK 1 uM":"48364.2345","19 MCF7 GSK 1 uM":"51678.7400","15 MCF7 DMM 5 mM":"17846.7908","18 MCF7 DMM 5 mM":"11162.6569","17 MCF7 Combination":"9544.8936","20 MCF7 Combination":"8469.5535","28 MDA-MB-231 GSK 1 uM":"430265.2536","31 MDA-MB-231 GSK 1 uM":"551073.5766","27 MDA-MB-231 DMM 5 mM":"247444.8870","30 MDA-MB-231 DMM 5 mM":"260285.1916","29 MDA-MB-231 Combination":"141455.1061","32 MDA-MB-231 Combination":"209955.9080","04 MDA-MB-468 GSK 1 uM":"1774875.8410","07 MDA-MB-468 GSK 1 uM":"2145174.2800","03 MDA-MB-468 DMM 5 mM":"736563.7478","06 MDA-MB-468 DMM 5 mM":"743738.2290","05 MDA-MB-468 Combination":"768177.2848","08 MDA-MB-468 Combination":"1139471.0900","01 Blank":"1029.0948","46 Blank":"2448.0637","02 DMEM/F12 no adds":"1158.6076","45 DMEM/F12 no adds":"2223.5889","10 SUM159PT GSK 1 uM":"1204132.4600","13 SUM159PT GSK 1 uM":"1450232.9440","09 SUM159PT DMM 5 mM":"37808.2881","12 SUM159PT DMM 5 mM":"47830.4027","11 SUM159PT Combination":"91499.2948","14 SUM159PT Combination":"81984.9626"},{"Metabolite":"Fumaric 71","40 CAL120 GSK 1 uM":"2794064.1210","43 CAL120 GSK 1 uM":"3330798.9320","39 CAL120 DMM 5 mM":"1497419.0750","42 CAL120 DMM 5 mM":"1810768.4540","41 CAL120 Combination":"1241637.5820","44 CAL120 Combination":"1360959.2260","22 HCC1806 GSK 1 uM":"4568346.8970","25 HCC1806 GSK 1 uM":"4393777.1360","21 HCC1806 DMM 5 mM":"3396910.5370","24 HCC1806 DMM 5 mM":"4041075.0290","23 HCC1806 Combination":"3841598.0800","26 HCC1806 Combination":"3567608.9140","34 HS578T GSK 1 uM":"766048.9276","37 HS578T GSK 1 uM":"771847.7242","33 HS578T DMM 5 mM":"306357.0957","36 HS578T DMM 5 mM":"341513.8948","35 HS578T Combination":"238879.8696","38 HS578T Combination":"287381.1960","16 MCF7 GSK 1 uM":"2741886.6240","19 MCF7 GSK 1 uM":"3489240.7610","15 MCF7 DMM 5 mM":"3402287.0580","18 MCF7 DMM 5 mM":"2853843.1180","17 MCF7 Combination":"2147862.4780","20 MCF7 Combination":"1297026.4370","28 MDA-MB-231 GSK 1 uM":"2881578.9700","31 MDA-MB-231 GSK 1 uM":"3349044.7850","27 MDA-MB-231 DMM 5 mM":"3414402.0430","30 MDA-MB-231 DMM 5 mM":"3136759.5230","29 MDA-MB-231 Combination":"2039024.0570","32 MDA-MB-231 Combination":"2444908.2550","04 MDA-MB-468 GSK 1 uM":"4987771.1860","07 MDA-MB-468 GSK 1 uM":"5378243.3740","03 MDA-MB-468 DMM 5 mM":"4044660.7000","06 MDA-MB-468 DMM 5 mM":"4444101.8950","05 MDA-MB-468 Combination":"4324972.1710","08 MDA-MB-468 Combination":"4168280.9520","01 Blank":"22073.3714","46 Blank":"34724.2796","02 DMEM/F12 no adds":"70391.2110","45 DMEM/F12 no adds":"27886.5932","10 SUM159PT GSK 1 uM":"1977976.2550","13 SUM159PT GSK 1 uM":"2645165.9940","09 SUM159PT DMM 5 mM":"2616258.2630","12 SUM159PT DMM 5 mM":"3018338.8290","11 SUM159PT Combination":"2826532.1120","14 SUM159PT Combination":"2967415.0470"},{"Metabolite":"Glucose 59","40 CAL120 GSK 1 uM":"4488907.3870","43 CAL120 GSK 1 uM":"3380164.6930","39 CAL120 DMM 5 mM":"9055107.3130","42 CAL120 DMM 5 mM":"4713801.1470","41 CAL120 Combination":"5174976.1720","44 CAL120 Combination":"2585091.8280","22 HCC1806 GSK 1 uM":"6337810.7260","25 HCC1806 GSK 1 uM":"4312610.3620","21 HCC1806 DMM 5 mM":"15940460.8000","24 HCC1806 DMM 5 mM":"6987449.6520","23 HCC1806 Combination":"6773405.2910","26 HCC1806 Combination":"8151764.1450","34 HS578T GSK 1 uM":"3725574.6280","37 HS578T GSK 1 uM":"7940606.5890","33 HS578T DMM 5 mM":"7007314.1110","36 HS578T DMM 5 mM":"4501572.3050","35 HS578T Combination":"6557321.0310","38 HS578T Combination":"3940922.0440","16 MCF7 GSK 1 uM":"7217630.2200","19 MCF7 GSK 1 uM":"4569358.6850","15 MCF7 DMM 5 mM":"7640710.1910","18 MCF7 DMM 5 mM":"15799389.2000","17 MCF7 Combination":"5021759.6440","20 MCF7 Combination":"3342084.9030","28 MDA-MB-231 GSK 1 uM":"7417430.5150","31 MDA-MB-231 GSK 1 uM":"5011585.3200","27 MDA-MB-231 DMM 5 mM":"7196784.1510","30 MDA-MB-231 DMM 5 mM":"9443964.2600","29 MDA-MB-231 Combination":"6550059.6090","32 MDA-MB-231 Combination":"4144326.9200","04 MDA-MB-468 GSK 1 uM":"3673310.5060","07 MDA-MB-468 GSK 1 uM":"4547162.3330","03 MDA-MB-468 DMM 5 mM":"21956215.3500","06 MDA-MB-468 DMM 5 mM":"18667430.5200","05 MDA-MB-468 Combination":"10858797.4800","08 MDA-MB-468 Combination":"20253660.1300","01 Blank":"13830.5057","46 Blank":"21487.7275","02 DMEM/F12 no adds":"199245533.1000","45 DMEM/F12 no adds":"203690163.7000","10 SUM159PT GSK 1 uM":"1545885.9410","13 SUM159PT GSK 1 uM":"1234705.0210","09 SUM159PT DMM 5 mM":"2397569.2370","12 SUM159PT DMM 5 mM":"1492663.4180","11 SUM159PT Combination":"1724992.8830","14 SUM159PT Combination":"2177260.3970"},{"Metabolite":"Glucose 6-phosphate 139","40 CAL120 GSK 1 uM":"106364.8497","43 CAL120 GSK 1 uM":"141825.8076","39 CAL120 DMM 5 mM":"59769.7974","42 CAL120 DMM 5 mM":"59412.0347","41 CAL120 Combination":"48188.1615","44 CAL120 Combination":"68534.5310","22 HCC1806 GSK 1 uM":"181372.9954","25 HCC1806 GSK 1 uM":"107864.3601","21 HCC1806 DMM 5 mM":"127130.6736","24 HCC1806 DMM 5 mM":"138090.0429","23 HCC1806 Combination":"273142.0203","26 HCC1806 Combination":"185032.5860","34 HS578T GSK 1 uM":"44689.0694","37 HS578T GSK 1 uM":"47998.2011","33 HS578T DMM 5 mM":"39607.3828","36 HS578T DMM 5 mM":"47202.9218","35 HS578T Combination":"48023.3152","38 HS578T Combination":"22810.0974","16 MCF7 GSK 1 uM":"75249.8853","19 MCF7 GSK 1 uM":"51171.1370","15 MCF7 DMM 5 mM":"66699.8416","18 MCF7 DMM 5 mM":"60630.2620","17 MCF7 Combination":"67807.6954","20 MCF7 Combination":"50035.5201","28 MDA-MB-231 GSK 1 uM":"115531.6915","31 MDA-MB-231 GSK 1 uM":"132907.9536","27 MDA-MB-231 DMM 5 mM":"88533.6091","30 MDA-MB-231 DMM 5 mM":"88949.9333","29 MDA-MB-231 Combination":"101479.2209","32 MDA-MB-231 Combination":"115707.1833","04 MDA-MB-468 GSK 1 uM":"283852.4469","07 MDA-MB-468 GSK 1 uM":"389698.4277","03 MDA-MB-468 DMM 5 mM":"538605.3620","06 MDA-MB-468 DMM 5 mM":"590626.0168","05 MDA-MB-468 Combination":"564986.8825","08 MDA-MB-468 Combination":"573007.3159","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"75716.5281","13 SUM159PT GSK 1 uM":"117064.7287","09 SUM159PT DMM 5 mM":"19139.0583","12 SUM159PT DMM 5 mM":"22814.2242","11 SUM159PT Combination":"57613.5342","14 SUM159PT Combination":"42791.3460"},{"Metabolite":"Glucose 6-phosphate 97","40 CAL120 GSK 1 uM":"2026967.9000","43 CAL120 GSK 1 uM":"2738438.2200","39 CAL120 DMM 5 mM":"972363.5822","42 CAL120 DMM 5 mM":"1040372.3830","41 CAL120 Combination":"1274612.2480","44 CAL120 Combination":"1221800.4450","22 HCC1806 GSK 1 uM":"2716403.2760","25 HCC1806 GSK 1 uM":"1453289.5550","21 HCC1806 DMM 5 mM":"2471989.0560","24 HCC1806 DMM 5 mM":"2523914.3770","23 HCC1806 Combination":"3775194.5310","26 HCC1806 Combination":"3285291.4590","34 HS578T GSK 1 uM":"856579.6655","37 HS578T GSK 1 uM":"1015630.4680","33 HS578T DMM 5 mM":"822311.2164","36 HS578T DMM 5 mM":"764353.3499","35 HS578T Combination":"925243.4874","38 HS578T Combination":"525985.6557","16 MCF7 GSK 1 uM":"1254541.2370","19 MCF7 GSK 1 uM":"1035510.5410","15 MCF7 DMM 5 mM":"1222296.3430","18 MCF7 DMM 5 mM":"1228868.7190","17 MCF7 Combination":"1311124.5480","20 MCF7 Combination":"930774.6172","28 MDA-MB-231 GSK 1 uM":"2282329.6200","31 MDA-MB-231 GSK 1 uM":"2624751.9030","27 MDA-MB-231 DMM 5 mM":"1624951.2500","30 MDA-MB-231 DMM 5 mM":"1703745.9570","29 MDA-MB-231 Combination":"1694180.2080","32 MDA-MB-231 Combination":"2314351.0820","04 MDA-MB-468 GSK 1 uM":"4702890.4450","07 MDA-MB-468 GSK 1 uM":"6057922.4570","03 MDA-MB-468 DMM 5 mM":"8007747.4350","06 MDA-MB-468 DMM 5 mM":"8651794.5120","05 MDA-MB-468 Combination":"8813050.1850","08 MDA-MB-468 Combination":"9410476.8370","01 Blank":"925.9904","46 Blank":"1191.8880","02 DMEM/F12 no adds":"163.4657","45 DMEM/F12 no adds":"607.1463","10 SUM159PT GSK 1 uM":"1327327.3230","13 SUM159PT GSK 1 uM":"2135759.3330","09 SUM159PT DMM 5 mM":"465743.7096","12 SUM159PT DMM 5 mM":"515161.0043","11 SUM159PT Combination":"971612.4705","14 SUM159PT Combination":"848045.3991"},{"Metabolite":"Glucose 71","40 CAL120 GSK 1 uM":"1492842.4300","43 CAL120 GSK 1 uM":"1033501.8520","39 CAL120 DMM 5 mM":"2971288.0670","42 CAL120 DMM 5 mM":"1543753.9600","41 CAL120 Combination":"1749321.2270","44 CAL120 Combination":"888359.5508","22 HCC1806 GSK 1 uM":"1868515.2690","25 HCC1806 GSK 1 uM":"1414362.1610","21 HCC1806 DMM 5 mM":"5250012.5770","24 HCC1806 DMM 5 mM":"2417958.2740","23 HCC1806 Combination":"2206291.8550","26 HCC1806 Combination":"2742442.8570","34 HS578T GSK 1 uM":"1171190.4910","37 HS578T GSK 1 uM":"2612735.1560","33 HS578T DMM 5 mM":"2294838.2290","36 HS578T DMM 5 mM":"1477420.1450","35 HS578T Combination":"2196880.3810","38 HS578T Combination":"1293306.5410","16 MCF7 GSK 1 uM":"2494901.4110","19 MCF7 GSK 1 uM":"1537444.1480","15 MCF7 DMM 5 mM":"2560272.6920","18 MCF7 DMM 5 mM":"5162643.4080","17 MCF7 Combination":"1664811.1480","20 MCF7 Combination":"1154739.5190","28 MDA-MB-231 GSK 1 uM":"2167431.4140","31 MDA-MB-231 GSK 1 uM":"1655517.7650","27 MDA-MB-231 DMM 5 mM":"2361482.5260","30 MDA-MB-231 DMM 5 mM":"3143134.1220","29 MDA-MB-231 Combination":"2106992.1390","32 MDA-MB-231 Combination":"1158073.7990","04 MDA-MB-468 GSK 1 uM":"1136569.1490","07 MDA-MB-468 GSK 1 uM":"1243077.7990","03 MDA-MB-468 DMM 5 mM":"6734190.8970","06 MDA-MB-468 DMM 5 mM":"6232720.1680","05 MDA-MB-468 Combination":"3731162.9910","08 MDA-MB-468 Combination":"6796127.9300","01 Blank":"","46 Blank":"341.3185","02 DMEM/F12 no adds":"76423112.5100","45 DMEM/F12 no adds":"77404089.1000","10 SUM159PT GSK 1 uM":"448331.6062","13 SUM159PT GSK 1 uM":"342139.7880","09 SUM159PT DMM 5 mM":"778188.7841","12 SUM159PT DMM 5 mM":"511908.1187","11 SUM159PT Combination":"555540.0681","14 SUM159PT Combination":"731561.3851"},{"Metabolite":"Glutamic acid 102","40 CAL120 GSK 1 uM":"115026084.1000","43 CAL120 GSK 1 uM":"102991643.8000","39 CAL120 DMM 5 mM":"84971525.4600","42 CAL120 DMM 5 mM":"92332029.6700","41 CAL120 Combination":"90509490.0900","44 CAL120 Combination":"89692490.1200","22 HCC1806 GSK 1 uM":"102918497.4000","25 HCC1806 GSK 1 uM":"109668590.9000","21 HCC1806 DMM 5 mM":"117050546.9000","24 HCC1806 DMM 5 mM":"95923783.1400","23 HCC1806 Combination":"113385505.0000","26 HCC1806 Combination":"116119195.6000","34 HS578T GSK 1 uM":"101282455.3000","37 HS578T GSK 1 uM":"117020645.4000","33 HS578T DMM 5 mM":"84552986.2900","36 HS578T DMM 5 mM":"74357364.2900","35 HS578T Combination":"93838421.9200","38 HS578T Combination":"71797286.9800","16 MCF7 GSK 1 uM":"76706054.7400","19 MCF7 GSK 1 uM":"100726997.0000","15 MCF7 DMM 5 mM":"92389338.0100","18 MCF7 DMM 5 mM":"92841230.1600","17 MCF7 Combination":"66629685.7200","20 MCF7 Combination":"58171149.2500","28 MDA-MB-231 GSK 1 uM":"93238844.2900","31 MDA-MB-231 GSK 1 uM":"90521132.3600","27 MDA-MB-231 DMM 5 mM":"88888206.2400","30 MDA-MB-231 DMM 5 mM":"91744621.4800","29 MDA-MB-231 Combination":"70668306.9400","32 MDA-MB-231 Combination":"74817075.5900","04 MDA-MB-468 GSK 1 uM":"70183729.4800","07 MDA-MB-468 GSK 1 uM":"74652383.7100","03 MDA-MB-468 DMM 5 mM":"48171533.2700","06 MDA-MB-468 DMM 5 mM":"59645189.6700","05 MDA-MB-468 Combination":"54715771.9800","08 MDA-MB-468 Combination":"71478145.0300","01 Blank":"9694.9120","46 Blank":"20897.6102","02 DMEM/F12 no adds":"11460571.6100","45 DMEM/F12 no adds":"15431340.2500","10 SUM159PT GSK 1 uM":"101312945.8000","13 SUM159PT GSK 1 uM":"116886091.1000","09 SUM159PT DMM 5 mM":"77610074.7700","12 SUM159PT DMM 5 mM":"90444633.8300","11 SUM159PT Combination":"77358288.2700","14 SUM159PT Combination":"83368839.9700"},{"Metabolite":"Glutamic acid 128","40 CAL120 GSK 1 uM":"39096495.8300","43 CAL120 GSK 1 uM":"33798971.4300","39 CAL120 DMM 5 mM":"27427303.6700","42 CAL120 DMM 5 mM":"28032329.7500","41 CAL120 Combination":"28175259.0700","44 CAL120 Combination":"27832809.7500","22 HCC1806 GSK 1 uM":"31875379.2900","25 HCC1806 GSK 1 uM":"35161843.6200","21 HCC1806 DMM 5 mM":"39211351.2700","24 HCC1806 DMM 5 mM":"30028641.1600","23 HCC1806 Combination":"36214827.0600","26 HCC1806 Combination":"36671079.4400","34 HS578T GSK 1 uM":"32430861.4600","37 HS578T GSK 1 uM":"37533314.1800","33 HS578T DMM 5 mM":"26385260.5800","36 HS578T DMM 5 mM":"22378642.3100","35 HS578T Combination":"29970151.9900","38 HS578T Combination":"21783552.9100","16 MCF7 GSK 1 uM":"22945846.5800","19 MCF7 GSK 1 uM":"32167976.8900","15 MCF7 DMM 5 mM":"29106635.3900","18 MCF7 DMM 5 mM":"29428744.3200","17 MCF7 Combination":"20422281.9000","20 MCF7 Combination":"16256380.9500","28 MDA-MB-231 GSK 1 uM":"29619411.0800","31 MDA-MB-231 GSK 1 uM":"27698664.3700","27 MDA-MB-231 DMM 5 mM":"27529233.2800","30 MDA-MB-231 DMM 5 mM":"28112256.2000","29 MDA-MB-231 Combination":"21536891.7000","32 MDA-MB-231 Combination":"22659484.9400","04 MDA-MB-468 GSK 1 uM":"21136794.4800","07 MDA-MB-468 GSK 1 uM":"21811045.5500","03 MDA-MB-468 DMM 5 mM":"13821525.5600","06 MDA-MB-468 DMM 5 mM":"17165144.8700","05 MDA-MB-468 Combination":"15900426.3500","08 MDA-MB-468 Combination":"22446047.3100","01 Blank":"1549.1224","46 Blank":"4248.5702","02 DMEM/F12 no adds":"3563557.2390","45 DMEM/F12 no adds":"4364397.7780","10 SUM159PT GSK 1 uM":"31511735.7000","13 SUM159PT GSK 1 uM":"37637615.9900","09 SUM159PT DMM 5 mM":"23769082.0400","12 SUM159PT DMM 5 mM":"27810583.0800","11 SUM159PT Combination":"23529506.3600","14 SUM159PT Combination":"25417970.3000"},{"Metabolite":"Glycerol 2-phosphate 127","40 CAL120 GSK 1 uM":"5106.7800","43 CAL120 GSK 1 uM":"1955.3805","39 CAL120 DMM 5 mM":"5428.2397","42 CAL120 DMM 5 mM":"1567.3595","41 CAL120 Combination":"52637.4504","44 CAL120 Combination":"8851.4775","22 HCC1806 GSK 1 uM":"7555.8182","25 HCC1806 GSK 1 uM":"9539.7079","21 HCC1806 DMM 5 mM":"4684.3824","24 HCC1806 DMM 5 mM":"8250.6461","23 HCC1806 Combination":"3002.0179","26 HCC1806 Combination":"1208.4745","34 HS578T GSK 1 uM":"13798.9244","37 HS578T GSK 1 uM":"3004.6234","33 HS578T DMM 5 mM":"211.2474","36 HS578T DMM 5 mM":"3991.2188","35 HS578T Combination":"2482.9099","38 HS578T Combination":"1318.2669","16 MCF7 GSK 1 uM":"76023.8816","19 MCF7 GSK 1 uM":"1170.1536","15 MCF7 DMM 5 mM":"8106.7241","18 MCF7 DMM 5 mM":"14738.1873","17 MCF7 Combination":"8196.9772","20 MCF7 Combination":"2892.7958","28 MDA-MB-231 GSK 1 uM":"6119.3026","31 MDA-MB-231 GSK 1 uM":"5261.1193","27 MDA-MB-231 DMM 5 mM":"14402.9770","30 MDA-MB-231 DMM 5 mM":"3860.5422","29 MDA-MB-231 Combination":"9822.2174","32 MDA-MB-231 Combination":"6893.9523","04 MDA-MB-468 GSK 1 uM":"91916.9482","07 MDA-MB-468 GSK 1 uM":"95729.3052","03 MDA-MB-468 DMM 5 mM":"4216.1164","06 MDA-MB-468 DMM 5 mM":"7470.9660","05 MDA-MB-468 Combination":"1642.1272","08 MDA-MB-468 Combination":"115584.5798","01 Blank":"6632.0235","46 Blank":"6598.0672","02 DMEM/F12 no adds":"2861.7158","45 DMEM/F12 no adds":"5672.2179","10 SUM159PT GSK 1 uM":"6638.6878","13 SUM159PT GSK 1 uM":"2395.2331","09 SUM159PT DMM 5 mM":"3961.2528","12 SUM159PT DMM 5 mM":"2531.2179","11 SUM159PT Combination":"6148.8003","14 SUM159PT Combination":"2076.1116"},{"Metabolite":"Glycerol 2-phosphate 79","40 CAL120 GSK 1 uM":"2335590.9850","43 CAL120 GSK 1 uM":"2247245.6890","39 CAL120 DMM 5 mM":"1627893.3040","42 CAL120 DMM 5 mM":"1622597.7440","41 CAL120 Combination":"1927113.7280","44 CAL120 Combination":"1932925.8440","22 HCC1806 GSK 1 uM":"5065399.7150","25 HCC1806 GSK 1 uM":"4714255.1340","21 HCC1806 DMM 5 mM":"2743804.0270","24 HCC1806 DMM 5 mM":"2430925.2420","23 HCC1806 Combination":"2446514.6340","26 HCC1806 Combination":"2638825.8720","34 HS578T GSK 1 uM":"2320072.9620","37 HS578T GSK 1 uM":"2650524.4100","33 HS578T DMM 5 mM":"1617683.0390","36 HS578T DMM 5 mM":"1552365.2710","35 HS578T Combination":"2135650.7710","38 HS578T Combination":"1658068.7910","16 MCF7 GSK 1 uM":"4050368.5220","19 MCF7 GSK 1 uM":"5139582.4200","15 MCF7 DMM 5 mM":"2319747.6330","18 MCF7 DMM 5 mM":"2158854.1230","17 MCF7 Combination":"3078303.5140","20 MCF7 Combination":"2093229.3500","28 MDA-MB-231 GSK 1 uM":"2453608.7900","31 MDA-MB-231 GSK 1 uM":"2707286.5560","27 MDA-MB-231 DMM 5 mM":"1907435.3430","30 MDA-MB-231 DMM 5 mM":"1896170.8830","29 MDA-MB-231 Combination":"1670886.5560","32 MDA-MB-231 Combination":"1764572.7400","04 MDA-MB-468 GSK 1 uM":"7478110.7480","07 MDA-MB-468 GSK 1 uM":"7823529.6520","03 MDA-MB-468 DMM 5 mM":"3107460.6660","06 MDA-MB-468 DMM 5 mM":"3414820.9440","05 MDA-MB-468 Combination":"3882556.9040","08 MDA-MB-468 Combination":"3979029.0480","01 Blank":"469.1275","46 Blank":"4066.0599","02 DMEM/F12 no adds":"1000.1229","45 DMEM/F12 no adds":"91.3775","10 SUM159PT GSK 1 uM":"69939983.5600","13 SUM159PT GSK 1 uM":"87021868.3700","09 SUM159PT DMM 5 mM":"27702512.4200","12 SUM159PT DMM 5 mM":"27577997.1000","11 SUM159PT Combination":"39833236.1200","14 SUM159PT Combination":"41344801.9800"},{"Metabolite":"GSSG 179","40 CAL120 GSK 1 uM":"133291.0487","43 CAL120 GSK 1 uM":"83476.5226","39 CAL120 DMM 5 mM":"93026.1769","42 CAL120 DMM 5 mM":"119208.6926","41 CAL120 Combination":"176815.7397","44 CAL120 Combination":"119638.9729","22 HCC1806 GSK 1 uM":"144181.6043","25 HCC1806 GSK 1 uM":"146363.2952","21 HCC1806 DMM 5 mM":"176802.0946","24 HCC1806 DMM 5 mM":"69126.3486","23 HCC1806 Combination":"87635.7963","26 HCC1806 Combination":"102030.9266","34 HS578T GSK 1 uM":"34436.5277","37 HS578T GSK 1 uM":"56756.1754","33 HS578T DMM 5 mM":"46531.7454","36 HS578T DMM 5 mM":"30780.9653","35 HS578T Combination":"64822.9460","38 HS578T Combination":"28558.9253","16 MCF7 GSK 1 uM":"45690.3476","19 MCF7 GSK 1 uM":"45903.1621","15 MCF7 DMM 5 mM":"49336.0890","18 MCF7 DMM 5 mM":"60213.5989","17 MCF7 Combination":"54690.7654","20 MCF7 Combination":"28253.4964","28 MDA-MB-231 GSK 1 uM":"76644.5023","31 MDA-MB-231 GSK 1 uM":"50244.4754","27 MDA-MB-231 DMM 5 mM":"69512.3584","30 MDA-MB-231 DMM 5 mM":"92891.0802","29 MDA-MB-231 Combination":"51489.3382","32 MDA-MB-231 Combination":"47074.3061","04 MDA-MB-468 GSK 1 uM":"266007.7966","07 MDA-MB-468 GSK 1 uM":"259268.6454","03 MDA-MB-468 DMM 5 mM":"181091.0440","06 MDA-MB-468 DMM 5 mM":"261837.2623","05 MDA-MB-468 Combination":"218093.1366","08 MDA-MB-468 Combination":"371008.9024","01 Blank":"","46 Blank":"136.5292","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"632.4416","10 SUM159PT GSK 1 uM":"81529.8644","13 SUM159PT GSK 1 uM":"113258.5168","09 SUM159PT DMM 5 mM":"80768.9391","12 SUM159PT DMM 5 mM":"120414.7951","11 SUM159PT Combination":"95619.7196","14 SUM159PT Combination":"106531.9753"},{"Metabolite":"GSSG 306","40 CAL120 GSK 1 uM":"1401809.7070","43 CAL120 GSK 1 uM":"954493.1070","39 CAL120 DMM 5 mM":"988953.3603","42 CAL120 DMM 5 mM":"1312557.2760","41 CAL120 Combination":"1872071.0700","44 CAL120 Combination":"1367150.9200","22 HCC1806 GSK 1 uM":"1484656.0170","25 HCC1806 GSK 1 uM":"1564190.2400","21 HCC1806 DMM 5 mM":"1834907.6740","24 HCC1806 DMM 5 mM":"871018.7750","23 HCC1806 Combination":"1008570.3120","26 HCC1806 Combination":"1122000.7540","34 HS578T GSK 1 uM":"366592.2400","37 HS578T GSK 1 uM":"620186.3003","33 HS578T DMM 5 mM":"482030.4559","36 HS578T DMM 5 mM":"330316.0979","35 HS578T Combination":"710640.4593","38 HS578T Combination":"337628.2948","16 MCF7 GSK 1 uM":"469201.7548","19 MCF7 GSK 1 uM":"514294.4623","15 MCF7 DMM 5 mM":"574746.2768","18 MCF7 DMM 5 mM":"659501.5279","17 MCF7 Combination":"570449.9808","20 MCF7 Combination":"309752.2214","28 MDA-MB-231 GSK 1 uM":"873285.8989","31 MDA-MB-231 GSK 1 uM":"572632.3234","27 MDA-MB-231 DMM 5 mM":"800361.0295","30 MDA-MB-231 DMM 5 mM":"1000085.8560","29 MDA-MB-231 Combination":"544332.4308","32 MDA-MB-231 Combination":"560098.7162","04 MDA-MB-468 GSK 1 uM":"2872987.1400","07 MDA-MB-468 GSK 1 uM":"2872002.5100","03 MDA-MB-468 DMM 5 mM":"1954805.1490","06 MDA-MB-468 DMM 5 mM":"2871450.5370","05 MDA-MB-468 Combination":"2406944.9860","08 MDA-MB-468 Combination":"4156107.4290","01 Blank":"1282.0144","46 Blank":"1953.2377","02 DMEM/F12 no adds":"1023.1123","45 DMEM/F12 no adds":"8451.7370","10 SUM159PT GSK 1 uM":"917215.9902","13 SUM159PT GSK 1 uM":"1108001.4750","09 SUM159PT DMM 5 mM":"868413.2248","12 SUM159PT DMM 5 mM":"1389908.7410","11 SUM159PT Combination":"975782.9734","14 SUM159PT Combination":"1288071.6320"},{"Metabolite":"HEPES 107","40 CAL120 GSK 1 uM":"29611.3017","43 CAL120 GSK 1 uM":"43051.7722","39 CAL120 DMM 5 mM":"31503.5350","42 CAL120 DMM 5 mM":"70360.1240","41 CAL120 Combination":"40051.1304","44 CAL120 Combination":"61749.8032","22 HCC1806 GSK 1 uM":"41378.6143","25 HCC1806 GSK 1 uM":"71370.4935","21 HCC1806 DMM 5 mM":"63630.0830","24 HCC1806 DMM 5 mM":"45894.2678","23 HCC1806 Combination":"36352.1389","26 HCC1806 Combination":"34706.6639","34 HS578T GSK 1 uM":"15663.8906","37 HS578T GSK 1 uM":"15118.0638","33 HS578T DMM 5 mM":"21107.3851","36 HS578T DMM 5 mM":"18862.0163","35 HS578T Combination":"16700.5306","38 HS578T Combination":"9598.5873","16 MCF7 GSK 1 uM":"21996.9334","19 MCF7 GSK 1 uM":"31527.0015","15 MCF7 DMM 5 mM":"44064.2174","18 MCF7 DMM 5 mM":"28386.3453","17 MCF7 Combination":"18073.3848","20 MCF7 Combination":"25052.0946","28 MDA-MB-231 GSK 1 uM":"45836.6877","31 MDA-MB-231 GSK 1 uM":"46686.3759","27 MDA-MB-231 DMM 5 mM":"28834.0805","30 MDA-MB-231 DMM 5 mM":"23400.6961","29 MDA-MB-231 Combination":"32068.5789","32 MDA-MB-231 Combination":"26438.5841","04 MDA-MB-468 GSK 1 uM":"40059.4921","07 MDA-MB-468 GSK 1 uM":"36341.2575","03 MDA-MB-468 DMM 5 mM":"38975.5909","06 MDA-MB-468 DMM 5 mM":"36472.5359","05 MDA-MB-468 Combination":"30911.0941","08 MDA-MB-468 Combination":"71280.6653","01 Blank":"143.6466","46 Blank":"","02 DMEM/F12 no adds":"1546373.8220","45 DMEM/F12 no adds":"1663623.7480","10 SUM159PT GSK 1 uM":"89382.1105","13 SUM159PT GSK 1 uM":"109534.4478","09 SUM159PT DMM 5 mM":"56359.7537","12 SUM159PT DMM 5 mM":"50308.3668","11 SUM159PT Combination":"56268.8158","14 SUM159PT Combination":"61879.5877"},{"Metabolite":"HEPES 80","40 CAL120 GSK 1 uM":"1324083.3620","43 CAL120 GSK 1 uM":"2836729.5250","39 CAL120 DMM 5 mM":"1988722.8670","42 CAL120 DMM 5 mM":"2828285.6120","41 CAL120 Combination":"1764805.3220","44 CAL120 Combination":"1627132.4060","22 HCC1806 GSK 1 uM":"2947659.3460","25 HCC1806 GSK 1 uM":"2669734.0510","21 HCC1806 DMM 5 mM":"1805207.1080","24 HCC1806 DMM 5 mM":"2410134.1240","23 HCC1806 Combination":"1658593.2290","26 HCC1806 Combination":"2624165.5250","34 HS578T GSK 1 uM":"1152116.1720","37 HS578T GSK 1 uM":"698951.0924","33 HS578T DMM 5 mM":"982601.6984","36 HS578T DMM 5 mM":"556953.8806","35 HS578T Combination":"644371.9614","38 HS578T Combination":"1218230.6840","16 MCF7 GSK 1 uM":"964674.7651","19 MCF7 GSK 1 uM":"2318169.0740","15 MCF7 DMM 5 mM":"982935.7425","18 MCF7 DMM 5 mM":"2806685.2690","17 MCF7 Combination":"1300285.3060","20 MCF7 Combination":"648301.7075","28 MDA-MB-231 GSK 1 uM":"1228925.0040","31 MDA-MB-231 GSK 1 uM":"1765483.1530","27 MDA-MB-231 DMM 5 mM":"1707777.5180","30 MDA-MB-231 DMM 5 mM":"1839159.3190","29 MDA-MB-231 Combination":"968976.8206","32 MDA-MB-231 Combination":"897134.0256","04 MDA-MB-468 GSK 1 uM":"2986142.1990","07 MDA-MB-468 GSK 1 uM":"3206634.8390","03 MDA-MB-468 DMM 5 mM":"1885365.4420","06 MDA-MB-468 DMM 5 mM":"2517706.8640","05 MDA-MB-468 Combination":"2278110.2770","08 MDA-MB-468 Combination":"2411280.0750","01 Blank":"422.4188","46 Blank":"6456.6788","02 DMEM/F12 no adds":"63769948.2100","45 DMEM/F12 no adds":"66912980.7300","10 SUM159PT GSK 1 uM":"3702892.3100","13 SUM159PT GSK 1 uM":"4602575.2500","09 SUM159PT DMM 5 mM":"4930562.0970","12 SUM159PT DMM 5 mM":"4495043.4230","11 SUM159PT Combination":"4569785.7140","14 SUM159PT Combination":"5000227.4430"},{"Metabolite":"HMG-CoA 408","40 CAL120 GSK 1 uM":"7316.9695","43 CAL120 GSK 1 uM":"6915.6514","39 CAL120 DMM 5 mM":"17652.8609","42 CAL120 DMM 5 mM":"19449.9625","41 CAL120 Combination":"12951.1442","44 CAL120 Combination":"10741.0698","22 HCC1806 GSK 1 uM":"3879.0546","25 HCC1806 GSK 1 uM":"5037.3607","21 HCC1806 DMM 5 mM":"28085.4662","24 HCC1806 DMM 5 mM":"27895.5956","23 HCC1806 Combination":"7916.1728","26 HCC1806 Combination":"7583.7961","34 HS578T GSK 1 uM":"7553.9669","37 HS578T GSK 1 uM":"8490.7291","33 HS578T DMM 5 mM":"13029.9888","36 HS578T DMM 5 mM":"11647.9933","35 HS578T Combination":"12215.1965","38 HS578T Combination":"13614.6375","16 MCF7 GSK 1 uM":"2670.5544","19 MCF7 GSK 1 uM":"2928.2809","15 MCF7 DMM 5 mM":"9216.0481","18 MCF7 DMM 5 mM":"4986.2978","17 MCF7 Combination":"1370.8170","20 MCF7 Combination":"1108.9334","28 MDA-MB-231 GSK 1 uM":"103.2214","31 MDA-MB-231 GSK 1 uM":"314.0282","27 MDA-MB-231 DMM 5 mM":"3285.0529","30 MDA-MB-231 DMM 5 mM":"3548.7999","29 MDA-MB-231 Combination":"105.5577","32 MDA-MB-231 Combination":"911.8229","04 MDA-MB-468 GSK 1 uM":"34060.4938","07 MDA-MB-468 GSK 1 uM":"39483.7840","03 MDA-MB-468 DMM 5 mM":"36983.9961","06 MDA-MB-468 DMM 5 mM":"41830.4755","05 MDA-MB-468 Combination":"23599.8716","08 MDA-MB-468 Combination":"24376.0696","01 Blank":"81.3833","46 Blank":"177.2739","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"93.4671","10 SUM159PT GSK 1 uM":"9641.1867","13 SUM159PT GSK 1 uM":"11364.0132","09 SUM159PT DMM 5 mM":"18298.1335","12 SUM159PT DMM 5 mM":"26044.7254","11 SUM159PT Combination":"7027.7545","14 SUM159PT Combination":"9644.6117"},{"Metabolite":"HMG-CoA 426","40 CAL120 GSK 1 uM":"5510.9049","43 CAL120 GSK 1 uM":"2853.9957","39 CAL120 DMM 5 mM":"7681.6239","42 CAL120 DMM 5 mM":"10722.7018","41 CAL120 Combination":"6473.0387","44 CAL120 Combination":"1287.8351","22 HCC1806 GSK 1 uM":"2414.0920","25 HCC1806 GSK 1 uM":"254.7642","21 HCC1806 DMM 5 mM":"15463.9557","24 HCC1806 DMM 5 mM":"14098.1829","23 HCC1806 Combination":"2401.0142","26 HCC1806 Combination":"5644.8714","34 HS578T GSK 1 uM":"3840.0997","37 HS578T GSK 1 uM":"3140.5461","33 HS578T DMM 5 mM":"5809.2624","36 HS578T DMM 5 mM":"6698.6133","35 HS578T Combination":"4685.1681","38 HS578T Combination":"4163.7113","16 MCF7 GSK 1 uM":"1186.5909","19 MCF7 GSK 1 uM":"729.1582","15 MCF7 DMM 5 mM":"4512.4236","18 MCF7 DMM 5 mM":"2080.4629","17 MCF7 Combination":"208.4630","20 MCF7 Combination":"","28 MDA-MB-231 GSK 1 uM":"96.1074","31 MDA-MB-231 GSK 1 uM":"103.5502","27 MDA-MB-231 DMM 5 mM":"2250.7090","30 MDA-MB-231 DMM 5 mM":"1609.6897","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"323.4579","04 MDA-MB-468 GSK 1 uM":"12082.2501","07 MDA-MB-468 GSK 1 uM":"20176.8273","03 MDA-MB-468 DMM 5 mM":"15436.3427","06 MDA-MB-468 DMM 5 mM":"18279.8161","05 MDA-MB-468 Combination":"9724.2334","08 MDA-MB-468 Combination":"13570.8491","01 Blank":"","46 Blank":"89.8266","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"1328.5777","13 SUM159PT GSK 1 uM":"6540.2659","09 SUM159PT DMM 5 mM":"10003.6922","12 SUM159PT DMM 5 mM":"9230.7892","11 SUM159PT Combination":"2464.1133","14 SUM159PT Combination":"3404.7438"},{"Metabolite":"Ketoglutaric 101","40 CAL120 GSK 1 uM":"12383599.1400","43 CAL120 GSK 1 uM":"13377263.0600","39 CAL120 DMM 5 mM":"7987955.2150","42 CAL120 DMM 5 mM":"8301250.4450","41 CAL120 Combination":"7920482.0920","44 CAL120 Combination":"7306936.8000","22 HCC1806 GSK 1 uM":"10113978.8000","25 HCC1806 GSK 1 uM":"9380783.1870","21 HCC1806 DMM 5 mM":"9343729.3310","24 HCC1806 DMM 5 mM":"9084482.4520","23 HCC1806 Combination":"7755760.0370","26 HCC1806 Combination":"7710934.3790","34 HS578T GSK 1 uM":"5066673.0710","37 HS578T GSK 1 uM":"5262462.3700","33 HS578T DMM 5 mM":"3492722.5370","36 HS578T DMM 5 mM":"3753808.3640","35 HS578T Combination":"4066057.1140","38 HS578T Combination":"2714561.4890","16 MCF7 GSK 1 uM":"11021954.3600","19 MCF7 GSK 1 uM":"16329648.6800","15 MCF7 DMM 5 mM":"12102810.7300","18 MCF7 DMM 5 mM":"11079771.0800","17 MCF7 Combination":"8918789.4420","20 MCF7 Combination":"5092884.3670","28 MDA-MB-231 GSK 1 uM":"11341452.9400","31 MDA-MB-231 GSK 1 uM":"12635213.5200","27 MDA-MB-231 DMM 5 mM":"13504251.4700","30 MDA-MB-231 DMM 5 mM":"12885458.3100","29 MDA-MB-231 Combination":"8695375.8490","32 MDA-MB-231 Combination":"11400176.9700","04 MDA-MB-468 GSK 1 uM":"6326990.8520","07 MDA-MB-468 GSK 1 uM":"7185836.5110","03 MDA-MB-468 DMM 5 mM":"5725287.6270","06 MDA-MB-468 DMM 5 mM":"5727425.6750","05 MDA-MB-468 Combination":"4872493.0580","08 MDA-MB-468 Combination":"5063629.4430","01 Blank":"78428.6740","46 Blank":"56912.7165","02 DMEM/F12 no adds":"101605.5870","45 DMEM/F12 no adds":"222119.1252","10 SUM159PT GSK 1 uM":"3385659.0320","13 SUM159PT GSK 1 uM":"3144281.3630","09 SUM159PT DMM 5 mM":"4537318.2830","12 SUM159PT DMM 5 mM":"4491943.2450","11 SUM159PT Combination":"3849078.9500","14 SUM159PT Combination":"4376886.9810"},{"Metabolite":"Ketoglutaric 57","40 CAL120 GSK 1 uM":"2187916.5190","43 CAL120 GSK 1 uM":"2679128.3200","39 CAL120 DMM 5 mM":"1431003.8610","42 CAL120 DMM 5 mM":"1500402.3600","41 CAL120 Combination":"1561186.3340","44 CAL120 Combination":"1329680.5550","22 HCC1806 GSK 1 uM":"1763042.2720","25 HCC1806 GSK 1 uM":"1751353.8520","21 HCC1806 DMM 5 mM":"1619759.3770","24 HCC1806 DMM 5 mM":"1640277.3850","23 HCC1806 Combination":"1389436.4620","26 HCC1806 Combination":"1353694.4880","34 HS578T GSK 1 uM":"1122105.7520","37 HS578T GSK 1 uM":"1028250.7590","33 HS578T DMM 5 mM":"902057.1527","36 HS578T DMM 5 mM":"722373.2550","35 HS578T Combination":"810017.3481","38 HS578T Combination":"694422.1600","16 MCF7 GSK 1 uM":"1966205.8420","19 MCF7 GSK 1 uM":"2755259.7590","15 MCF7 DMM 5 mM":"2227222.9010","18 MCF7 DMM 5 mM":"2094502.1500","17 MCF7 Combination":"1508541.4510","20 MCF7 Combination":"882474.0466","28 MDA-MB-231 GSK 1 uM":"2020466.5840","31 MDA-MB-231 GSK 1 uM":"2278350.6800","27 MDA-MB-231 DMM 5 mM":"2261833.1320","30 MDA-MB-231 DMM 5 mM":"2340456.8470","29 MDA-MB-231 Combination":"1776243.0480","32 MDA-MB-231 Combination":"2078768.6320","04 MDA-MB-468 GSK 1 uM":"1245324.5510","07 MDA-MB-468 GSK 1 uM":"1253224.7480","03 MDA-MB-468 DMM 5 mM":"1078968.4220","06 MDA-MB-468 DMM 5 mM":"1165415.6390","05 MDA-MB-468 Combination":"931481.4980","08 MDA-MB-468 Combination":"982907.2050","01 Blank":"42410.2649","46 Blank":"148925.2590","02 DMEM/F12 no adds":"57137.5727","45 DMEM/F12 no adds":"111091.5870","10 SUM159PT GSK 1 uM":"780026.3897","13 SUM159PT GSK 1 uM":"699332.0519","09 SUM159PT DMM 5 mM":"914022.2891","12 SUM159PT DMM 5 mM":"1041299.9090","11 SUM159PT Combination":"666892.9079","14 SUM159PT Combination":"900522.5059"},{"Metabolite":"Lactic 71","40 CAL120 GSK 1 uM":"1144975.4600","43 CAL120 GSK 1 uM":"1201586.7440","39 CAL120 DMM 5 mM":"1373802.2070","42 CAL120 DMM 5 mM":"713521.6381","41 CAL120 Combination":"584578.3253","44 CAL120 Combination":"750767.9062","22 HCC1806 GSK 1 uM":"5788174.5380","25 HCC1806 GSK 1 uM":"5244012.4850","21 HCC1806 DMM 5 mM":"5066814.9760","24 HCC1806 DMM 5 mM":"3648200.4210","23 HCC1806 Combination":"3130966.4320","26 HCC1806 Combination":"2936316.1110","34 HS578T GSK 1 uM":"837935.1952","37 HS578T GSK 1 uM":"1165169.2370","33 HS578T DMM 5 mM":"833231.7614","36 HS578T DMM 5 mM":"499737.4629","35 HS578T Combination":"1069564.2030","38 HS578T Combination":"680795.7232","16 MCF7 GSK 1 uM":"2356356.0830","19 MCF7 GSK 1 uM":"2757731.4800","15 MCF7 DMM 5 mM":"2025021.7620","18 MCF7 DMM 5 mM":"2199032.3070","17 MCF7 Combination":"1626887.3190","20 MCF7 Combination":"1072424.9670","28 MDA-MB-231 GSK 1 uM":"3113813.6880","31 MDA-MB-231 GSK 1 uM":"3037227.7240","27 MDA-MB-231 DMM 5 mM":"3371489.7810","30 MDA-MB-231 DMM 5 mM":"3404654.2340","29 MDA-MB-231 Combination":"2291223.0730","32 MDA-MB-231 Combination":"2597929.3860","04 MDA-MB-468 GSK 1 uM":"13035020.7800","07 MDA-MB-468 GSK 1 uM":"14854165.8400","03 MDA-MB-468 DMM 5 mM":"10993012.2200","06 MDA-MB-468 DMM 5 mM":"9789873.4330","05 MDA-MB-468 Combination":"9046316.2860","08 MDA-MB-468 Combination":"10079012.1000","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"3326340.1500","13 SUM159PT GSK 1 uM":"4078207.7320","09 SUM159PT DMM 5 mM":"2983677.0250","12 SUM159PT DMM 5 mM":"2360872.2550","11 SUM159PT Combination":"2032889.0690","14 SUM159PT Combination":"2393890.1380"},{"Metabolite":"Lactic 87","40 CAL120 GSK 1 uM":"551009.6655","43 CAL120 GSK 1 uM":"887211.3807","39 CAL120 DMM 5 mM":"883133.2177","42 CAL120 DMM 5 mM":"500624.9175","41 CAL120 Combination":"381720.3295","44 CAL120 Combination":"513994.1723","22 HCC1806 GSK 1 uM":"3850911.9480","25 HCC1806 GSK 1 uM":"3409140.2580","21 HCC1806 DMM 5 mM":"3367883.0360","24 HCC1806 DMM 5 mM":"2715164.2880","23 HCC1806 Combination":"2038391.7280","26 HCC1806 Combination":"2024852.2720","34 HS578T GSK 1 uM":"524912.6682","37 HS578T GSK 1 uM":"712378.3784","33 HS578T DMM 5 mM":"611229.1028","36 HS578T DMM 5 mM":"449914.4333","35 HS578T Combination":"778493.6187","38 HS578T Combination":"515269.6325","16 MCF7 GSK 1 uM":"1501373.5910","19 MCF7 GSK 1 uM":"1333215.4140","15 MCF7 DMM 5 mM":"1460385.6440","18 MCF7 DMM 5 mM":"1444007.9640","17 MCF7 Combination":"1142597.1730","20 MCF7 Combination":"682380.8717","28 MDA-MB-231 GSK 1 uM":"2132543.3080","31 MDA-MB-231 GSK 1 uM":"2136931.3220","27 MDA-MB-231 DMM 5 mM":"1996900.4340","30 MDA-MB-231 DMM 5 mM":"2279377.7820","29 MDA-MB-231 Combination":"1587006.3200","32 MDA-MB-231 Combination":"1712044.6760","04 MDA-MB-468 GSK 1 uM":"8823361.3060","07 MDA-MB-468 GSK 1 uM":"9232625.1170","03 MDA-MB-468 DMM 5 mM":"6950782.0260","06 MDA-MB-468 DMM 5 mM":"6549935.2410","05 MDA-MB-468 Combination":"5938997.8180","08 MDA-MB-468 Combination":"6842872.9110","01 Blank":"4740.6716","46 Blank":"4105.4661","02 DMEM/F12 no adds":"1115.0477","45 DMEM/F12 no adds":"1826.5887","10 SUM159PT GSK 1 uM":"2116891.0350","13 SUM159PT GSK 1 uM":"2578998.0970","09 SUM159PT DMM 5 mM":"1821700.6130","12 SUM159PT DMM 5 mM":"1730476.2880","11 SUM159PT Combination":"1421365.1630","14 SUM159PT Combination":"1788602.7250"},{"Metabolite":"Lauroyl-CoA 408","40 CAL120 GSK 1 uM":"228.7595","43 CAL120 GSK 1 uM":"113.6152","39 CAL120 DMM 5 mM":"1247.1979","42 CAL120 DMM 5 mM":"919.3525","41 CAL120 Combination":"460.3139","44 CAL120 Combination":"454.9881","22 HCC1806 GSK 1 uM":"354.0356","25 HCC1806 GSK 1 uM":"687.9443","21 HCC1806 DMM 5 mM":"348.3471","24 HCC1806 DMM 5 mM":"460.1835","23 HCC1806 Combination":"794.9828","26 HCC1806 Combination":"1376.7075","34 HS578T GSK 1 uM":"674.3677","37 HS578T GSK 1 uM":"224.9119","33 HS578T DMM 5 mM":"454.9992","36 HS578T DMM 5 mM":"344.5889","35 HS578T Combination":"453.9663","38 HS578T Combination":"1025.7327","16 MCF7 GSK 1 uM":"229.7376","19 MCF7 GSK 1 uM":"234.3333","15 MCF7 DMM 5 mM":"1713.0525","18 MCF7 DMM 5 mM":"1142.5432","17 MCF7 Combination":"341.6443","20 MCF7 Combination":"341.6750","28 MDA-MB-231 GSK 1 uM":"902.5390","31 MDA-MB-231 GSK 1 uM":"690.8095","27 MDA-MB-231 DMM 5 mM":"748.1303","30 MDA-MB-231 DMM 5 mM":"342.0264","29 MDA-MB-231 Combination":"937.3032","32 MDA-MB-231 Combination":"124.0076","04 MDA-MB-468 GSK 1 uM":"568.3747","07 MDA-MB-468 GSK 1 uM":"333.0324","03 MDA-MB-468 DMM 5 mM":"679.6239","06 MDA-MB-468 DMM 5 mM":"1591.9282","05 MDA-MB-468 Combination":"456.9295","08 MDA-MB-468 Combination":"246.8192","01 Blank":"446.4121","46 Blank":"111.6740","02 DMEM/F12 no adds":"334.9336","45 DMEM/F12 no adds":"113.0694","10 SUM159PT GSK 1 uM":"466.5562","13 SUM159PT GSK 1 uM":"572.2381","09 SUM159PT DMM 5 mM":"569.2962","12 SUM159PT DMM 5 mM":"623.4322","11 SUM159PT Combination":"453.5578","14 SUM159PT Combination":"116.0694"},{"Metabolite":"Maleic 27","40 CAL120 GSK 1 uM":"12000.5076","43 CAL120 GSK 1 uM":"7619.6131","39 CAL120 DMM 5 mM":"12453.2844","42 CAL120 DMM 5 mM":"11224.6412","41 CAL120 Combination":"8703.4772","44 CAL120 Combination":"9972.7911","22 HCC1806 GSK 1 uM":"4265.9802","25 HCC1806 GSK 1 uM":"","21 HCC1806 DMM 5 mM":"7039.5383","24 HCC1806 DMM 5 mM":"4134.3552","23 HCC1806 Combination":"8346.0676","26 HCC1806 Combination":"2391.2682","34 HS578T GSK 1 uM":"12118.8862","37 HS578T GSK 1 uM":"8544.5506","33 HS578T DMM 5 mM":"13217.7221","36 HS578T DMM 5 mM":"1948.3703","35 HS578T Combination":"8877.6423","38 HS578T Combination":"","16 MCF7 GSK 1 uM":"","19 MCF7 GSK 1 uM":"","15 MCF7 DMM 5 mM":"","18 MCF7 DMM 5 mM":"","17 MCF7 Combination":"","20 MCF7 Combination":"","28 MDA-MB-231 GSK 1 uM":"4233.2300","31 MDA-MB-231 GSK 1 uM":"2704.4291","27 MDA-MB-231 DMM 5 mM":"","30 MDA-MB-231 DMM 5 mM":"4061.3887","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"","04 MDA-MB-468 GSK 1 uM":"","07 MDA-MB-468 GSK 1 uM":"","03 MDA-MB-468 DMM 5 mM":"","06 MDA-MB-468 DMM 5 mM":"","05 MDA-MB-468 Combination":"","08 MDA-MB-468 Combination":"","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"1125.4802","13 SUM159PT GSK 1 uM":"2558.2605","09 SUM159PT DMM 5 mM":"2357.8825","12 SUM159PT DMM 5 mM":"4704.7868","11 SUM159PT Combination":"","14 SUM159PT Combination":"2620.5941"},{"Metabolite":"Maleic 71","40 CAL120 GSK 1 uM":"1344892.0910","43 CAL120 GSK 1 uM":"1309933.5080","39 CAL120 DMM 5 mM":"1551451.2880","42 CAL120 DMM 5 mM":"1303816.7590","41 CAL120 Combination":"1491202.2420","44 CAL120 Combination":"1367687.8010","22 HCC1806 GSK 1 uM":"1067842.8780","25 HCC1806 GSK 1 uM":"1079756.6090","21 HCC1806 DMM 5 mM":"1198325.9560","24 HCC1806 DMM 5 mM":"1089509.6640","23 HCC1806 Combination":"1052841.4990","26 HCC1806 Combination":"986726.6656","34 HS578T GSK 1 uM":"1499378.2560","37 HS578T GSK 1 uM":"1572898.0540","33 HS578T DMM 5 mM":"1433501.8990","36 HS578T DMM 5 mM":"1543029.4460","35 HS578T Combination":"1790801.9540","38 HS578T Combination":"513809.1547","16 MCF7 GSK 1 uM":"593747.7695","19 MCF7 GSK 1 uM":"533952.9712","15 MCF7 DMM 5 mM":"620105.9366","18 MCF7 DMM 5 mM":"492093.0588","17 MCF7 Combination":"643219.3219","20 MCF7 Combination":"642975.2387","28 MDA-MB-231 GSK 1 uM":"752464.9240","31 MDA-MB-231 GSK 1 uM":"745105.9988","27 MDA-MB-231 DMM 5 mM":"715793.9861","30 MDA-MB-231 DMM 5 mM":"805355.8620","29 MDA-MB-231 Combination":"905625.6609","32 MDA-MB-231 Combination":"860304.9323","04 MDA-MB-468 GSK 1 uM":"308166.6379","07 MDA-MB-468 GSK 1 uM":"318639.6106","03 MDA-MB-468 DMM 5 mM":"262789.4845","06 MDA-MB-468 DMM 5 mM":"310641.2220","05 MDA-MB-468 Combination":"294677.0662","08 MDA-MB-468 Combination":"358409.9669","01 Blank":"365771.4416","46 Blank":"481280.4450","02 DMEM/F12 no adds":"160662.1266","45 DMEM/F12 no adds":"78124.6164","10 SUM159PT GSK 1 uM":"889366.4497","13 SUM159PT GSK 1 uM":"874003.0611","09 SUM159PT DMM 5 mM":"948932.5426","12 SUM159PT DMM 5 mM":"972954.1367","11 SUM159PT Combination":"955824.1678","14 SUM159PT Combination":"983022.4899"},{"Metabolite":"Malic 115","40 CAL120 GSK 1 uM":"35106472.1600","43 CAL120 GSK 1 uM":"42169589.7100","39 CAL120 DMM 5 mM":"19972521.6400","42 CAL120 DMM 5 mM":"22710923.7100","41 CAL120 Combination":"16985702.5100","44 CAL120 Combination":"19212713.9300","22 HCC1806 GSK 1 uM":"57323140.1800","25 HCC1806 GSK 1 uM":"56631623.5400","21 HCC1806 DMM 5 mM":"46118545.3500","24 HCC1806 DMM 5 mM":"51590586.7700","23 HCC1806 Combination":"49292527.4200","26 HCC1806 Combination":"45673134.0100","34 HS578T GSK 1 uM":"11154877.0100","37 HS578T GSK 1 uM":"9323598.5360","33 HS578T DMM 5 mM":"3381562.8310","36 HS578T DMM 5 mM":"4089807.2900","35 HS578T Combination":"3126054.1490","38 HS578T Combination":"3958072.4250","16 MCF7 GSK 1 uM":"37661575.0800","19 MCF7 GSK 1 uM":"45243930.4500","15 MCF7 DMM 5 mM":"43843002.1500","18 MCF7 DMM 5 mM":"36835793.8200","17 MCF7 Combination":"25781832.1600","20 MCF7 Combination":"16121734.8100","28 MDA-MB-231 GSK 1 uM":"37980510.8300","31 MDA-MB-231 GSK 1 uM":"43155089.6400","27 MDA-MB-231 DMM 5 mM":"43495101.7200","30 MDA-MB-231 DMM 5 mM":"39486219.7600","29 MDA-MB-231 Combination":"26122317.3800","32 MDA-MB-231 Combination":"31612315.3800","04 MDA-MB-468 GSK 1 uM":"60436284.9400","07 MDA-MB-468 GSK 1 uM":"67633936.2800","03 MDA-MB-468 DMM 5 mM":"50302010.5500","06 MDA-MB-468 DMM 5 mM":"53038451.8700","05 MDA-MB-468 Combination":"52612167.4200","08 MDA-MB-468 Combination":"52283969.7000","01 Blank":"34309.0679","46 Blank":"46053.7454","02 DMEM/F12 no adds":"148271.0852","45 DMEM/F12 no adds":"100198.0175","10 SUM159PT GSK 1 uM":"26492794.8700","13 SUM159PT GSK 1 uM":"33355978.4800","09 SUM159PT DMM 5 mM":"36985283.6200","12 SUM159PT DMM 5 mM":"40443532.6700","11 SUM159PT Combination":"36634429.6300","14 SUM159PT Combination":"38929275.5100"},{"Metabolite":"Malic 71","40 CAL120 GSK 1 uM":"13235857.6900","43 CAL120 GSK 1 uM":"15581349.5500","39 CAL120 DMM 5 mM":"7268737.3870","42 CAL120 DMM 5 mM":"8265791.2270","41 CAL120 Combination":"6123534.6090","44 CAL120 Combination":"7208569.0040","22 HCC1806 GSK 1 uM":"20896416.0000","25 HCC1806 GSK 1 uM":"20754374.0100","21 HCC1806 DMM 5 mM":"16838465.5200","24 HCC1806 DMM 5 mM":"19120765.3400","23 HCC1806 Combination":"18243208.7100","26 HCC1806 Combination":"16959858.6600","34 HS578T GSK 1 uM":"4140250.3680","37 HS578T GSK 1 uM":"3522779.7080","33 HS578T DMM 5 mM":"1287167.8420","36 HS578T DMM 5 mM":"1516690.4210","35 HS578T Combination":"1143818.8270","38 HS578T Combination":"1519311.6400","16 MCF7 GSK 1 uM":"13995917.7700","19 MCF7 GSK 1 uM":"16878579.3300","15 MCF7 DMM 5 mM":"16043085.7400","18 MCF7 DMM 5 mM":"13711959.5900","17 MCF7 Combination":"9385783.8930","20 MCF7 Combination":"5704320.1560","28 MDA-MB-231 GSK 1 uM":"13682800.7400","31 MDA-MB-231 GSK 1 uM":"16111614.1100","27 MDA-MB-231 DMM 5 mM":"16434074.6100","30 MDA-MB-231 DMM 5 mM":"14800628.9800","29 MDA-MB-231 Combination":"9506495.6600","32 MDA-MB-231 Combination":"11751672.0700","04 MDA-MB-468 GSK 1 uM":"22437456.7600","07 MDA-MB-468 GSK 1 uM":"25709438.5400","03 MDA-MB-468 DMM 5 mM":"18953744.5500","06 MDA-MB-468 DMM 5 mM":"20087326.9800","05 MDA-MB-468 Combination":"19479950.5400","08 MDA-MB-468 Combination":"19072303.1500","01 Blank":"8001.7325","46 Blank":"13223.8168","02 DMEM/F12 no adds":"15076.7526","45 DMEM/F12 no adds":"26871.0463","10 SUM159PT GSK 1 uM":"9763886.7020","13 SUM159PT GSK 1 uM":"12031312.2500","09 SUM159PT DMM 5 mM":"13253180.2000","12 SUM159PT DMM 5 mM":"14830784.7500","11 SUM159PT Combination":"13579321.0500","14 SUM159PT Combination":"14329652.5200"},{"Metabolite":"Malonic 59","40 CAL120 GSK 1 uM":"1439498.4830","43 CAL120 GSK 1 uM":"1134310.0140","39 CAL120 DMM 5 mM":"37440281.2100","42 CAL120 DMM 5 mM":"36342424.3300","41 CAL120 Combination":"45137008.2300","44 CAL120 Combination":"44129677.3200","22 HCC1806 GSK 1 uM":"6870516.6470","25 HCC1806 GSK 1 uM":"7404074.0700","21 HCC1806 DMM 5 mM":"56023632.7000","24 HCC1806 DMM 5 mM":"55347213.3300","23 HCC1806 Combination":"80657875.9700","26 HCC1806 Combination":"83819094.5900","34 HS578T GSK 1 uM":"1522566.1200","37 HS578T GSK 1 uM":"1015594.8930","33 HS578T DMM 5 mM":"6974423.8890","36 HS578T DMM 5 mM":"6686049.6040","35 HS578T Combination":"8616934.6160","38 HS578T Combination":"6402571.3130","16 MCF7 GSK 1 uM":"3039355.9930","19 MCF7 GSK 1 uM":"3955618.9910","15 MCF7 DMM 5 mM":"47544712.4200","18 MCF7 DMM 5 mM":"43837041.9100","17 MCF7 Combination":"75666929.2800","20 MCF7 Combination":"49166757.7700","28 MDA-MB-231 GSK 1 uM":"2084483.4700","31 MDA-MB-231 GSK 1 uM":"1848223.3630","27 MDA-MB-231 DMM 5 mM":"37935357.0800","30 MDA-MB-231 DMM 5 mM":"37859990.7800","29 MDA-MB-231 Combination":"45355712.7500","32 MDA-MB-231 Combination":"50129916.8900","04 MDA-MB-468 GSK 1 uM":"3172319.1210","07 MDA-MB-468 GSK 1 uM":"3449184.5460","03 MDA-MB-468 DMM 5 mM":"128345329.8000","06 MDA-MB-468 DMM 5 mM":"125366381.7000","05 MDA-MB-468 Combination":"130533047.8000","08 MDA-MB-468 Combination":"132995967.1000","01 Blank":"22947.9909","46 Blank":"30373.6033","02 DMEM/F12 no adds":"48988.7473","45 DMEM/F12 no adds":"58819.5922","10 SUM159PT GSK 1 uM":"1062020.8440","13 SUM159PT GSK 1 uM":"824710.8607","09 SUM159PT DMM 5 mM":"22650873.0900","12 SUM159PT DMM 5 mM":"22771610.0000","11 SUM159PT Combination":"23748478.8200","14 SUM159PT Combination":"26716387.8400"},{"Metabolite":"Malonyl-CoA 408","40 CAL120 GSK 1 uM":"734165.6689","43 CAL120 GSK 1 uM":"704578.8961","39 CAL120 DMM 5 mM":"27117.1536","42 CAL120 DMM 5 mM":"28508.3659","41 CAL120 Combination":"599778.9678","44 CAL120 Combination":"616632.3192","22 HCC1806 GSK 1 uM":"817820.1625","25 HCC1806 GSK 1 uM":"888708.8026","21 HCC1806 DMM 5 mM":"38051.3895","24 HCC1806 DMM 5 mM":"28028.0551","23 HCC1806 Combination":"628799.7422","26 HCC1806 Combination":"671458.4402","34 HS578T GSK 1 uM":"145911.4771","37 HS578T GSK 1 uM":"168169.0665","33 HS578T DMM 5 mM":"9292.2721","36 HS578T DMM 5 mM":"6142.8102","35 HS578T Combination":"49460.8205","38 HS578T Combination":"21391.8419","16 MCF7 GSK 1 uM":"681154.2691","19 MCF7 GSK 1 uM":"869049.7209","15 MCF7 DMM 5 mM":"28085.1664","18 MCF7 DMM 5 mM":"26519.8018","17 MCF7 Combination":"792399.3425","20 MCF7 Combination":"452373.4031","28 MDA-MB-231 GSK 1 uM":"675698.8605","31 MDA-MB-231 GSK 1 uM":"661466.2045","27 MDA-MB-231 DMM 5 mM":"102542.9587","30 MDA-MB-231 DMM 5 mM":"108715.0708","29 MDA-MB-231 Combination":"439139.0795","32 MDA-MB-231 Combination":"613639.8775","04 MDA-MB-468 GSK 1 uM":"1054642.2930","07 MDA-MB-468 GSK 1 uM":"1122125.7510","03 MDA-MB-468 DMM 5 mM":"51678.4011","06 MDA-MB-468 DMM 5 mM":"55215.2144","05 MDA-MB-468 Combination":"929079.6152","08 MDA-MB-468 Combination":"1011027.7350","01 Blank":"129.9875","46 Blank":"213.8939","02 DMEM/F12 no adds":"90.9059","45 DMEM/F12 no adds":"943.4865","10 SUM159PT GSK 1 uM":"931668.9153","13 SUM159PT GSK 1 uM":"1196295.9980","09 SUM159PT DMM 5 mM":"26916.5215","12 SUM159PT DMM 5 mM":"33406.2942","11 SUM159PT Combination":"700397.1914","14 SUM159PT Combination":"739918.7552"},{"Metabolite":"Malonyl-CoA 426","40 CAL120 GSK 1 uM":"381665.1042","43 CAL120 GSK 1 uM":"356808.6937","39 CAL120 DMM 5 mM":"14457.2831","42 CAL120 DMM 5 mM":"12770.7211","41 CAL120 Combination":"298879.4939","44 CAL120 Combination":"308014.5097","22 HCC1806 GSK 1 uM":"417242.6865","25 HCC1806 GSK 1 uM":"450507.9210","21 HCC1806 DMM 5 mM":"14616.1843","24 HCC1806 DMM 5 mM":"11793.3925","23 HCC1806 Combination":"310028.1775","26 HCC1806 Combination":"351264.1808","34 HS578T GSK 1 uM":"70371.0117","37 HS578T GSK 1 uM":"79017.4642","33 HS578T DMM 5 mM":"4679.5706","36 HS578T DMM 5 mM":"3216.6379","35 HS578T Combination":"24776.9301","38 HS578T Combination":"8110.5809","16 MCF7 GSK 1 uM":"336392.1676","19 MCF7 GSK 1 uM":"451238.9147","15 MCF7 DMM 5 mM":"14448.7128","18 MCF7 DMM 5 mM":"9915.1256","17 MCF7 Combination":"395144.2502","20 MCF7 Combination":"229828.8141","28 MDA-MB-231 GSK 1 uM":"339444.6990","31 MDA-MB-231 GSK 1 uM":"323835.0609","27 MDA-MB-231 DMM 5 mM":"50485.8607","30 MDA-MB-231 DMM 5 mM":"52590.7940","29 MDA-MB-231 Combination":"222749.2701","32 MDA-MB-231 Combination":"297244.0672","04 MDA-MB-468 GSK 1 uM":"509653.3883","07 MDA-MB-468 GSK 1 uM":"579355.4636","03 MDA-MB-468 DMM 5 mM":"23614.0082","06 MDA-MB-468 DMM 5 mM":"28546.2204","05 MDA-MB-468 Combination":"497385.6856","08 MDA-MB-468 Combination":"539988.4763","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"54.8708","10 SUM159PT GSK 1 uM":"451359.1285","13 SUM159PT GSK 1 uM":"597408.5601","09 SUM159PT DMM 5 mM":"14194.4147","12 SUM159PT DMM 5 mM":"15645.6993","11 SUM159PT Combination":"354826.9406","14 SUM159PT Combination":"394293.9821"},{"Metabolite":"Mannitol 89","40 CAL120 GSK 1 uM":"1312020.4590","43 CAL120 GSK 1 uM":"1255409.6590","39 CAL120 DMM 5 mM":"434284.0424","42 CAL120 DMM 5 mM":"477399.5302","41 CAL120 Combination":"557176.5435","44 CAL120 Combination":"686738.4981","22 HCC1806 GSK 1 uM":"734997.4579","25 HCC1806 GSK 1 uM":"606512.6931","21 HCC1806 DMM 5 mM":"455821.4861","24 HCC1806 DMM 5 mM":"467174.7773","23 HCC1806 Combination":"547686.9613","26 HCC1806 Combination":"527995.4244","34 HS578T GSK 1 uM":"4682728.3980","37 HS578T GSK 1 uM":"4145883.0230","33 HS578T DMM 5 mM":"2791997.8820","36 HS578T DMM 5 mM":"2766539.3820","35 HS578T Combination":"3147891.3340","38 HS578T Combination":"2688925.1120","16 MCF7 GSK 1 uM":"185430.3981","19 MCF7 GSK 1 uM":"204658.3982","15 MCF7 DMM 5 mM":"136539.2327","18 MCF7 DMM 5 mM":"231875.7411","17 MCF7 Combination":"175043.6806","20 MCF7 Combination":"214885.1947","28 MDA-MB-231 GSK 1 uM":"3132644.4020","31 MDA-MB-231 GSK 1 uM":"3549573.8780","27 MDA-MB-231 DMM 5 mM":"1597708.6630","30 MDA-MB-231 DMM 5 mM":"1448614.1760","29 MDA-MB-231 Combination":"1604927.5670","32 MDA-MB-231 Combination":"1819291.4340","04 MDA-MB-468 GSK 1 uM":"8024264.9960","07 MDA-MB-468 GSK 1 uM":"9113726.8900","03 MDA-MB-468 DMM 5 mM":"5053686.6880","06 MDA-MB-468 DMM 5 mM":"5091716.2070","05 MDA-MB-468 Combination":"6523801.9480","08 MDA-MB-468 Combination":"6490477.7930","01 Blank":"1308.3506","46 Blank":"2596.3831","02 DMEM/F12 no adds":"831932.2355","45 DMEM/F12 no adds":"832470.8721","10 SUM159PT GSK 1 uM":"4876544.9360","13 SUM159PT GSK 1 uM":"6370587.6040","09 SUM159PT DMM 5 mM":"1368579.5610","12 SUM159PT DMM 5 mM":"1501893.4220","11 SUM159PT Combination":"1588232.0630","14 SUM159PT Combination":"1433062.2800"},{"Metabolite":"Mannose 59","40 CAL120 GSK 1 uM":"4346976.6970","43 CAL120 GSK 1 uM":"3536672.1630","39 CAL120 DMM 5 mM":"9990254.3590","42 CAL120 DMM 5 mM":"4536272.6210","41 CAL120 Combination":"5928381.0360","44 CAL120 Combination":"2607974.9800","22 HCC1806 GSK 1 uM":"5609932.6090","25 HCC1806 GSK 1 uM":"4283675.3200","21 HCC1806 DMM 5 mM":"15647676.6200","24 HCC1806 DMM 5 mM":"7279567.1740","23 HCC1806 Combination":"6574445.0090","26 HCC1806 Combination":"8428056.5550","34 HS578T GSK 1 uM":"4073185.6150","37 HS578T GSK 1 uM":"8312771.1500","33 HS578T DMM 5 mM":"6727492.4120","36 HS578T DMM 5 mM":"5008412.5200","35 HS578T Combination":"6374153.0650","38 HS578T Combination":"4010208.5540","16 MCF7 GSK 1 uM":"7785032.5690","19 MCF7 GSK 1 uM":"4805632.2270","15 MCF7 DMM 5 mM":"6793345.7440","18 MCF7 DMM 5 mM":"17855264.6900","17 MCF7 Combination":"5578415.9650","20 MCF7 Combination":"3677820.6180","28 MDA-MB-231 GSK 1 uM":"6345972.5450","31 MDA-MB-231 GSK 1 uM":"5122162.2240","27 MDA-MB-231 DMM 5 mM":"6982377.3010","30 MDA-MB-231 DMM 5 mM":"10876896.4600","29 MDA-MB-231 Combination":"6342747.7310","32 MDA-MB-231 Combination":"4334564.4480","04 MDA-MB-468 GSK 1 uM":"3614697.0400","07 MDA-MB-468 GSK 1 uM":"4121883.2280","03 MDA-MB-468 DMM 5 mM":"20324120.7700","06 MDA-MB-468 DMM 5 mM":"18937513.8300","05 MDA-MB-468 Combination":"10251699.8600","08 MDA-MB-468 Combination":"18425590.9000","01 Blank":"6720.1531","46 Blank":"20108.1133","02 DMEM/F12 no adds":"188223114.9000","45 DMEM/F12 no adds":"201628871.9000","10 SUM159PT GSK 1 uM":"1237174.8300","13 SUM159PT GSK 1 uM":"1248377.2650","09 SUM159PT DMM 5 mM":"2409846.2990","12 SUM159PT DMM 5 mM":"1541806.6710","11 SUM159PT Combination":"1974797.6460","14 SUM159PT Combination":"2390003.5940"},{"Metabolite":"Mannose 95","40 CAL120 GSK 1 uM":"1063.9108","43 CAL120 GSK 1 uM":"1200.5826","39 CAL120 DMM 5 mM":"268.5994","42 CAL120 DMM 5 mM":"588.8815","41 CAL120 Combination":"1337.3341","44 CAL120 Combination":"2158.0819","22 HCC1806 GSK 1 uM":"6230.8683","25 HCC1806 GSK 1 uM":"9666.8573","21 HCC1806 DMM 5 mM":"320.9252","24 HCC1806 DMM 5 mM":"1964.8391","23 HCC1806 Combination":"3207.8974","26 HCC1806 Combination":"691.1376","34 HS578T GSK 1 uM":"725.5838","37 HS578T GSK 1 uM":"2889.6761","33 HS578T DMM 5 mM":"3635.8824","36 HS578T DMM 5 mM":"870.7752","35 HS578T Combination":"380.5628","38 HS578T Combination":"113446.4330","16 MCF7 GSK 1 uM":"176863.9911","19 MCF7 GSK 1 uM":"744.4425","15 MCF7 DMM 5 mM":"157075.0376","18 MCF7 DMM 5 mM":"245.0739","17 MCF7 Combination":"2567.4882","20 MCF7 Combination":"1577.3921","28 MDA-MB-231 GSK 1 uM":"2885.7165","31 MDA-MB-231 GSK 1 uM":"97637.6143","27 MDA-MB-231 DMM 5 mM":"962.7559","30 MDA-MB-231 DMM 5 mM":"1491.0026","29 MDA-MB-231 Combination":"202.4634","32 MDA-MB-231 Combination":"1171.5807","04 MDA-MB-468 GSK 1 uM":"1054.8604","07 MDA-MB-468 GSK 1 uM":"1103.9164","03 MDA-MB-468 DMM 5 mM":"1183.9825","06 MDA-MB-468 DMM 5 mM":"1478.6400","05 MDA-MB-468 Combination":"3041.1658","08 MDA-MB-468 Combination":"1792.1615","01 Blank":"1365.8508","46 Blank":"138.9178","02 DMEM/F12 no adds":"822.9352","45 DMEM/F12 no adds":"299.3250","10 SUM159PT GSK 1 uM":"530.8457","13 SUM159PT GSK 1 uM":"971.6930","09 SUM159PT DMM 5 mM":"1128.1755","12 SUM159PT DMM 5 mM":"2041.5072","11 SUM159PT Combination":"1652.0963","14 SUM159PT Combination":"3116.0809"},{"Metabolite":"Methylcrotonyl-CoA 408","40 CAL120 GSK 1 uM":"6488.9599","43 CAL120 GSK 1 uM":"8828.7316","39 CAL120 DMM 5 mM":"6974.8403","42 CAL120 DMM 5 mM":"3858.8496","41 CAL120 Combination":"5557.0650","44 CAL120 Combination":"5259.7067","22 HCC1806 GSK 1 uM":"32192.0477","25 HCC1806 GSK 1 uM":"32342.5397","21 HCC1806 DMM 5 mM":"24163.9218","24 HCC1806 DMM 5 mM":"28827.9138","23 HCC1806 Combination":"28063.0671","26 HCC1806 Combination":"25651.2111","34 HS578T GSK 1 uM":"8473.0365","37 HS578T GSK 1 uM":"6738.7979","33 HS578T DMM 5 mM":"5442.9367","36 HS578T DMM 5 mM":"4013.9267","35 HS578T Combination":"6539.9689","38 HS578T Combination":"4953.6095","16 MCF7 GSK 1 uM":"7611.5191","19 MCF7 GSK 1 uM":"12441.4355","15 MCF7 DMM 5 mM":"11671.7086","18 MCF7 DMM 5 mM":"12322.2567","17 MCF7 Combination":"12049.7186","20 MCF7 Combination":"3953.5171","28 MDA-MB-231 GSK 1 uM":"20054.5091","31 MDA-MB-231 GSK 1 uM":"20238.5626","27 MDA-MB-231 DMM 5 mM":"19968.3935","30 MDA-MB-231 DMM 5 mM":"19001.0530","29 MDA-MB-231 Combination":"18357.4267","32 MDA-MB-231 Combination":"15359.0646","04 MDA-MB-468 GSK 1 uM":"28471.4176","07 MDA-MB-468 GSK 1 uM":"29363.5472","03 MDA-MB-468 DMM 5 mM":"30057.9117","06 MDA-MB-468 DMM 5 mM":"28043.6911","05 MDA-MB-468 Combination":"29765.3932","08 MDA-MB-468 Combination":"24880.8868","01 Blank":"105.5769","46 Blank":"241.8116","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"21778.0850","13 SUM159PT GSK 1 uM":"23480.6791","09 SUM159PT DMM 5 mM":"29548.7993","12 SUM159PT DMM 5 mM":"29069.6725","11 SUM159PT Combination":"23418.9038","14 SUM159PT Combination":"27723.1191"},{"Metabolite":"Methylcrotonyl-CoA 79","40 CAL120 GSK 1 uM":"75801.4955","43 CAL120 GSK 1 uM":"77798.5323","39 CAL120 DMM 5 mM":"60280.3960","42 CAL120 DMM 5 mM":"68969.6755","41 CAL120 Combination":"57812.1300","44 CAL120 Combination":"71720.1975","22 HCC1806 GSK 1 uM":"284896.7625","25 HCC1806 GSK 1 uM":"286565.8652","21 HCC1806 DMM 5 mM":"198539.2473","24 HCC1806 DMM 5 mM":"249551.0500","23 HCC1806 Combination":"258364.8865","26 HCC1806 Combination":"225629.2125","34 HS578T GSK 1 uM":"59848.4375","37 HS578T GSK 1 uM":"78081.6020","33 HS578T DMM 5 mM":"53157.2440","36 HS578T DMM 5 mM":"55411.4275","35 HS578T Combination":"61704.9315","38 HS578T Combination":"54415.8400","16 MCF7 GSK 1 uM":"68523.3560","19 MCF7 GSK 1 uM":"84167.7980","15 MCF7 DMM 5 mM":"118230.8311","18 MCF7 DMM 5 mM":"96867.2100","17 MCF7 Combination":"105076.5805","20 MCF7 Combination":"56479.6545","28 MDA-MB-231 GSK 1 uM":"154976.8945","31 MDA-MB-231 GSK 1 uM":"179854.6665","27 MDA-MB-231 DMM 5 mM":"187284.4610","30 MDA-MB-231 DMM 5 mM":"157937.6130","29 MDA-MB-231 Combination":"164475.1085","32 MDA-MB-231 Combination":"201803.8450","04 MDA-MB-468 GSK 1 uM":"252399.2325","07 MDA-MB-468 GSK 1 uM":"258652.2145","03 MDA-MB-468 DMM 5 mM":"245592.0485","06 MDA-MB-468 DMM 5 mM":"231221.2840","05 MDA-MB-468 Combination":"244377.5830","08 MDA-MB-468 Combination":"246149.4195","01 Blank":"315.7360","46 Blank":"636.2245","02 DMEM/F12 no adds":"476.7710","45 DMEM/F12 no adds":"1038.8045","10 SUM159PT GSK 1 uM":"170479.1340","13 SUM159PT GSK 1 uM":"208713.2612","09 SUM159PT DMM 5 mM":"220076.2505","12 SUM159PT DMM 5 mM":"253271.0190","11 SUM159PT Combination":"220684.8535","14 SUM159PT Combination":"236847.6340"},{"Metabolite":"Methylmalonic 55","40 CAL120 GSK 1 uM":"6655.0845","43 CAL120 GSK 1 uM":"11557.1328","39 CAL120 DMM 5 mM":"32346.4090","42 CAL120 DMM 5 mM":"36201.8693","41 CAL120 Combination":"34553.1459","44 CAL120 Combination":"50870.7598","22 HCC1806 GSK 1 uM":"8055.2563","25 HCC1806 GSK 1 uM":"6679.0344","21 HCC1806 DMM 5 mM":"23513.7524","24 HCC1806 DMM 5 mM":"27944.7324","23 HCC1806 Combination":"26924.5453","26 HCC1806 Combination":"47564.0641","34 HS578T GSK 1 uM":"14394.5837","37 HS578T GSK 1 uM":"9571.4091","33 HS578T DMM 5 mM":"15485.1601","36 HS578T DMM 5 mM":"19022.1974","35 HS578T Combination":"15731.1070","38 HS578T Combination":"3194.4141","16 MCF7 GSK 1 uM":"1299.8774","19 MCF7 GSK 1 uM":"3250.8502","15 MCF7 DMM 5 mM":"12922.7823","18 MCF7 DMM 5 mM":"9408.1063","17 MCF7 Combination":"37754.3145","20 MCF7 Combination":"29980.7478","28 MDA-MB-231 GSK 1 uM":"9112.3573","31 MDA-MB-231 GSK 1 uM":"3909.8121","27 MDA-MB-231 DMM 5 mM":"16984.0975","30 MDA-MB-231 DMM 5 mM":"11235.5582","29 MDA-MB-231 Combination":"12722.6386","32 MDA-MB-231 Combination":"9343.4007","04 MDA-MB-468 GSK 1 uM":"14667.2162","07 MDA-MB-468 GSK 1 uM":"20391.8442","03 MDA-MB-468 DMM 5 mM":"298502.0201","06 MDA-MB-468 DMM 5 mM":"332278.3650","05 MDA-MB-468 Combination":"443928.7749","08 MDA-MB-468 Combination":"431442.3113","01 Blank":"1131.8106","46 Blank":"1797.8233","02 DMEM/F12 no adds":"1842.7678","45 DMEM/F12 no adds":"1086.1445","10 SUM159PT GSK 1 uM":"8236.1316","13 SUM159PT GSK 1 uM":"7849.5547","09 SUM159PT DMM 5 mM":"10130.4111","12 SUM159PT DMM 5 mM":"5437.6326","11 SUM159PT Combination":"6749.4089","14 SUM159PT Combination":"7279.0350"},{"Metabolite":"Methylmalonic 73","40 CAL120 GSK 1 uM":"199995.3551","43 CAL120 GSK 1 uM":"2149.8335","39 CAL120 DMM 5 mM":"466099.9656","42 CAL120 DMM 5 mM":"496464.7582","41 CAL120 Combination":"528729.2087","44 CAL120 Combination":"587649.0276","22 HCC1806 GSK 1 uM":"13592.3480","25 HCC1806 GSK 1 uM":"15891.0872","21 HCC1806 DMM 5 mM":"118123.4138","24 HCC1806 DMM 5 mM":"429049.8862","23 HCC1806 Combination":"549556.8706","26 HCC1806 Combination":"522777.3051","34 HS578T GSK 1 uM":"106197.3348","37 HS578T GSK 1 uM":"188553.6973","33 HS578T DMM 5 mM":"203060.8750","36 HS578T DMM 5 mM":"113144.7682","35 HS578T Combination":"218156.9527","38 HS578T Combination":"7703.2046","16 MCF7 GSK 1 uM":"6735.6225","19 MCF7 GSK 1 uM":"4132.6193","15 MCF7 DMM 5 mM":"199419.9400","18 MCF7 DMM 5 mM":"211436.7110","17 MCF7 Combination":"415642.9813","20 MCF7 Combination":"251606.1003","28 MDA-MB-231 GSK 1 uM":"15061.3653","31 MDA-MB-231 GSK 1 uM":"31212.5791","27 MDA-MB-231 DMM 5 mM":"118414.8521","30 MDA-MB-231 DMM 5 mM":"165985.4338","29 MDA-MB-231 Combination":"48636.8767","32 MDA-MB-231 Combination":"92823.1713","04 MDA-MB-468 GSK 1 uM":"310156.5185","07 MDA-MB-468 GSK 1 uM":"328710.3749","03 MDA-MB-468 DMM 5 mM":"4159147.7750","06 MDA-MB-468 DMM 5 mM":"4149034.0580","05 MDA-MB-468 Combination":"5759808.9480","08 MDA-MB-468 Combination":"5614066.0380","01 Blank":"14989.0469","46 Blank":"5512.7890","02 DMEM/F12 no adds":"4181.6628","45 DMEM/F12 no adds":"1354.0581","10 SUM159PT GSK 1 uM":"25254.4555","13 SUM159PT GSK 1 uM":"10168.4867","09 SUM159PT DMM 5 mM":"221180.7017","12 SUM159PT DMM 5 mM":"127612.8026","11 SUM159PT Combination":"115072.7175","14 SUM159PT Combination":"107415.8526"},{"Metabolite":"myo-Inositol 161","40 CAL120 GSK 1 uM":"13751628.8400","43 CAL120 GSK 1 uM":"14906421.6400","39 CAL120 DMM 5 mM":"12951891.8800","42 CAL120 DMM 5 mM":"13041587.9900","41 CAL120 Combination":"12331046.2100","44 CAL120 Combination":"11874982.7100","22 HCC1806 GSK 1 uM":"12137381.8800","25 HCC1806 GSK 1 uM":"12317157.3500","21 HCC1806 DMM 5 mM":"9421815.7960","24 HCC1806 DMM 5 mM":"9587210.2670","23 HCC1806 Combination":"11440776.9000","26 HCC1806 Combination":"11041783.7200","34 HS578T GSK 1 uM":"2166446.0000","37 HS578T GSK 1 uM":"2212114.7620","33 HS578T DMM 5 mM":"1626201.1360","36 HS578T DMM 5 mM":"1648397.8320","35 HS578T Combination":"1867986.6770","38 HS578T Combination":"1704672.3320","16 MCF7 GSK 1 uM":"1012415.9450","19 MCF7 GSK 1 uM":"1252270.1170","15 MCF7 DMM 5 mM":"1449502.9640","18 MCF7 DMM 5 mM":"1501713.5830","17 MCF7 Combination":"1599351.2630","20 MCF7 Combination":"975601.7371","28 MDA-MB-231 GSK 1 uM":"4720797.0670","31 MDA-MB-231 GSK 1 uM":"5282011.0150","27 MDA-MB-231 DMM 5 mM":"5560141.5740","30 MDA-MB-231 DMM 5 mM":"5161198.0380","29 MDA-MB-231 Combination":"4441515.3670","32 MDA-MB-231 Combination":"5391886.8090","04 MDA-MB-468 GSK 1 uM":"3464147.4250","07 MDA-MB-468 GSK 1 uM":"3913759.8020","03 MDA-MB-468 DMM 5 mM":"4340878.9190","06 MDA-MB-468 DMM 5 mM":"4299021.9290","05 MDA-MB-468 Combination":"5004583.3420","08 MDA-MB-468 Combination":"5182530.0220","01 Blank":"28471.6160","46 Blank":"15530.6261","02 DMEM/F12 no adds":"1833244.5760","45 DMEM/F12 no adds":"2141686.5360","10 SUM159PT GSK 1 uM":"1156444.9890","13 SUM159PT GSK 1 uM":"1564356.5960","09 SUM159PT DMM 5 mM":"1715960.0000","12 SUM159PT DMM 5 mM":"1260250.2920","11 SUM159PT Combination":"935627.7475","14 SUM159PT Combination":"875506.3595"},{"Metabolite":"Myristic PAR","40 CAL120 GSK 1 uM":"141698.9442","43 CAL120 GSK 1 uM":"305545.5085","39 CAL120 DMM 5 mM":"428908.5161","42 CAL120 DMM 5 mM":"473459.9116","41 CAL120 Combination":"365103.4510","44 CAL120 Combination":"347840.3100","22 HCC1806 GSK 1 uM":"157362.8316","25 HCC1806 GSK 1 uM":"156332.3754","21 HCC1806 DMM 5 mM":"583082.2411","24 HCC1806 DMM 5 mM":"519078.7194","23 HCC1806 Combination":"281561.2041","26 HCC1806 Combination":"202637.3882","34 HS578T GSK 1 uM":"162763.8610","37 HS578T GSK 1 uM":"305155.8255","33 HS578T DMM 5 mM":"257300.1075","36 HS578T DMM 5 mM":"345780.5849","35 HS578T Combination":"449881.7440","38 HS578T Combination":"375056.7979","16 MCF7 GSK 1 uM":"156324.9030","19 MCF7 GSK 1 uM":"475374.8247","15 MCF7 DMM 5 mM":"484408.5743","18 MCF7 DMM 5 mM":"509322.2927","17 MCF7 Combination":"164031.3348","20 MCF7 Combination":"229962.8572","28 MDA-MB-231 GSK 1 uM":"67396.0336","31 MDA-MB-231 GSK 1 uM":"258963.1082","27 MDA-MB-231 DMM 5 mM":"247851.8136","30 MDA-MB-231 DMM 5 mM":"336370.9868","29 MDA-MB-231 Combination":"230164.2844","32 MDA-MB-231 Combination":"197461.0861","04 MDA-MB-468 GSK 1 uM":"413290.1705","07 MDA-MB-468 GSK 1 uM":"177490.3400","03 MDA-MB-468 DMM 5 mM":"488748.0326","06 MDA-MB-468 DMM 5 mM":"229527.7319","05 MDA-MB-468 Combination":"262994.8455","08 MDA-MB-468 Combination":"208972.4913","01 Blank":"18217.8694","46 Blank":"30050.2909","02 DMEM/F12 no adds":"164446.4853","45 DMEM/F12 no adds":"212384.3474","10 SUM159PT GSK 1 uM":"206341.3725","13 SUM159PT GSK 1 uM":"107333.8964","09 SUM159PT DMM 5 mM":"404747.1212","12 SUM159PT DMM 5 mM":"231759.8487","11 SUM159PT Combination":"231439.7327","14 SUM159PT Combination":"299835.3792"},{"Metabolite":"Myristoyl-CoA 408","40 CAL120 GSK 1 uM":"1490.0689","43 CAL120 GSK 1 uM":"2394.4201","39 CAL120 DMM 5 mM":"6327.8260","42 CAL120 DMM 5 mM":"6239.6108","41 CAL120 Combination":"1942.4853","44 CAL120 Combination":"3794.7500","22 HCC1806 GSK 1 uM":"5416.3262","25 HCC1806 GSK 1 uM":"4705.2959","21 HCC1806 DMM 5 mM":"8024.0697","24 HCC1806 DMM 5 mM":"7734.3778","23 HCC1806 Combination":"6182.9063","26 HCC1806 Combination":"2455.5449","34 HS578T GSK 1 uM":"688.8322","37 HS578T GSK 1 uM":"3095.2703","33 HS578T DMM 5 mM":"5137.9916","36 HS578T DMM 5 mM":"2414.1969","35 HS578T Combination":"1525.8722","38 HS578T Combination":"2175.1369","16 MCF7 GSK 1 uM":"1711.7602","19 MCF7 GSK 1 uM":"809.8458","15 MCF7 DMM 5 mM":"13622.6642","18 MCF7 DMM 5 mM":"11889.9385","17 MCF7 Combination":"917.6153","20 MCF7 Combination":"684.3008","28 MDA-MB-231 GSK 1 uM":"803.3609","31 MDA-MB-231 GSK 1 uM":"1236.0436","27 MDA-MB-231 DMM 5 mM":"4811.7809","30 MDA-MB-231 DMM 5 mM":"2407.4877","29 MDA-MB-231 Combination":"3438.3970","32 MDA-MB-231 Combination":"2048.1280","04 MDA-MB-468 GSK 1 uM":"5352.7876","07 MDA-MB-468 GSK 1 uM":"2505.7745","03 MDA-MB-468 DMM 5 mM":"13262.3566","06 MDA-MB-468 DMM 5 mM":"15474.3143","05 MDA-MB-468 Combination":"7093.3936","08 MDA-MB-468 Combination":"9930.8827","01 Blank":"116.2686","46 Blank":"222.8081","02 DMEM/F12 no adds":"222.9329","45 DMEM/F12 no adds":"224.1557","10 SUM159PT GSK 1 uM":"1236.5902","13 SUM159PT GSK 1 uM":"1485.1527","09 SUM159PT DMM 5 mM":"6745.8261","12 SUM159PT DMM 5 mM":"9052.1326","11 SUM159PT Combination":"1379.5052","14 SUM159PT Combination":"2758.4940"},{"Metabolite":"NAD+ 273","40 CAL120 GSK 1 uM":"2267472.8490","43 CAL120 GSK 1 uM":"2306194.0260","39 CAL120 DMM 5 mM":"2283423.3870","42 CAL120 DMM 5 mM":"2178740.1420","41 CAL120 Combination":"2231621.5640","44 CAL120 Combination":"2266789.2660","22 HCC1806 GSK 1 uM":"3838952.1110","25 HCC1806 GSK 1 uM":"3710976.0010","21 HCC1806 DMM 5 mM":"3623245.1890","24 HCC1806 DMM 5 mM":"3862792.7370","23 HCC1806 Combination":"3913995.2340","26 HCC1806 Combination":"3857804.2370","34 HS578T GSK 1 uM":"823561.3875","37 HS578T GSK 1 uM":"853643.7267","33 HS578T DMM 5 mM":"615561.1218","36 HS578T DMM 5 mM":"618915.5259","35 HS578T Combination":"716080.4091","38 HS578T Combination":"636596.1335","16 MCF7 GSK 1 uM":"1726849.1940","19 MCF7 GSK 1 uM":"2065787.8480","15 MCF7 DMM 5 mM":"2171972.2430","18 MCF7 DMM 5 mM":"2023813.7220","17 MCF7 Combination":"2463090.8980","20 MCF7 Combination":"1491451.5190","28 MDA-MB-231 GSK 1 uM":"2123509.9690","31 MDA-MB-231 GSK 1 uM":"2509883.0890","27 MDA-MB-231 DMM 5 mM":"2124338.6110","30 MDA-MB-231 DMM 5 mM":"2080414.6670","29 MDA-MB-231 Combination":"2014091.2990","32 MDA-MB-231 Combination":"2258980.8070","04 MDA-MB-468 GSK 1 uM":"3919070.6500","07 MDA-MB-468 GSK 1 uM":"4042469.8690","03 MDA-MB-468 DMM 5 mM":"3833880.9130","06 MDA-MB-468 DMM 5 mM":"3401480.0210","05 MDA-MB-468 Combination":"3789054.0590","08 MDA-MB-468 Combination":"3319935.1530","01 Blank":"","46 Blank":"1105.0107","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"3886.2444","10 SUM159PT GSK 1 uM":"3612957.1440","13 SUM159PT GSK 1 uM":"4068846.2360","09 SUM159PT DMM 5 mM":"3505512.1650","12 SUM159PT DMM 5 mM":"3885847.7340","11 SUM159PT Combination":"3713488.2370","14 SUM159PT Combination":"4189912.3150"},{"Metabolite":"NAD+ 540","40 CAL120 GSK 1 uM":"11767457.5900","43 CAL120 GSK 1 uM":"11797605.0800","39 CAL120 DMM 5 mM":"11740155.1200","42 CAL120 DMM 5 mM":"10853114.8400","41 CAL120 Combination":"11519472.3500","44 CAL120 Combination":"11622117.7200","22 HCC1806 GSK 1 uM":"20117541.6100","25 HCC1806 GSK 1 uM":"18966773.5200","21 HCC1806 DMM 5 mM":"18602674.4100","24 HCC1806 DMM 5 mM":"19857776.7000","23 HCC1806 Combination":"19925207.6700","26 HCC1806 Combination":"19722145.7900","34 HS578T GSK 1 uM":"4222338.2990","37 HS578T GSK 1 uM":"4287614.8490","33 HS578T DMM 5 mM":"3033395.1950","36 HS578T DMM 5 mM":"3151150.6330","35 HS578T Combination":"3871775.3150","38 HS578T Combination":"3399350.5930","16 MCF7 GSK 1 uM":"9090535.1390","19 MCF7 GSK 1 uM":"10735054.1300","15 MCF7 DMM 5 mM":"11183578.6100","18 MCF7 DMM 5 mM":"10457342.7300","17 MCF7 Combination":"13239535.8400","20 MCF7 Combination":"7887685.0420","28 MDA-MB-231 GSK 1 uM":"10823105.7200","31 MDA-MB-231 GSK 1 uM":"12856045.3800","27 MDA-MB-231 DMM 5 mM":"11116163.5100","30 MDA-MB-231 DMM 5 mM":"11108122.1200","29 MDA-MB-231 Combination":"10532051.2200","32 MDA-MB-231 Combination":"11935613.4000","04 MDA-MB-468 GSK 1 uM":"20639717.4700","07 MDA-MB-468 GSK 1 uM":"21213896.7900","03 MDA-MB-468 DMM 5 mM":"19628519.9500","06 MDA-MB-468 DMM 5 mM":"17965846.4200","05 MDA-MB-468 Combination":"19466931.7500","08 MDA-MB-468 Combination":"17455495.1400","01 Blank":"2908.4711","46 Blank":"11523.4266","02 DMEM/F12 no adds":"3047.8451","45 DMEM/F12 no adds":"13706.9621","10 SUM159PT GSK 1 uM":"19263670.3200","13 SUM159PT GSK 1 uM":"21135126.2100","09 SUM159PT DMM 5 mM":"19000437.8300","12 SUM159PT DMM 5 mM":"19975455.1200","11 SUM159PT Combination":"19477739.3400","14 SUM159PT Combination":"22219359.1200"},{"Metabolite":"NADH 335","40 CAL120 GSK 1 uM":"324858.0230","43 CAL120 GSK 1 uM":"289990.5117","39 CAL120 DMM 5 mM":"323804.9197","42 CAL120 DMM 5 mM":"231166.2644","41 CAL120 Combination":"288221.6812","44 CAL120 Combination":"257479.7425","22 HCC1806 GSK 1 uM":"941518.6083","25 HCC1806 GSK 1 uM":"1377543.3060","21 HCC1806 DMM 5 mM":"1267097.5750","24 HCC1806 DMM 5 mM":"788521.7532","23 HCC1806 Combination":"685271.2693","26 HCC1806 Combination":"841386.9323","34 HS578T GSK 1 uM":"255329.8165","37 HS578T GSK 1 uM":"359390.3499","33 HS578T DMM 5 mM":"335909.2927","36 HS578T DMM 5 mM":"318584.3135","35 HS578T Combination":"394928.4534","38 HS578T Combination":"227921.0817","16 MCF7 GSK 1 uM":"314364.2304","19 MCF7 GSK 1 uM":"326448.7608","15 MCF7 DMM 5 mM":"272266.4630","18 MCF7 DMM 5 mM":"266935.5694","17 MCF7 Combination":"260165.3215","20 MCF7 Combination":"153098.3008","28 MDA-MB-231 GSK 1 uM":"806435.2733","31 MDA-MB-231 GSK 1 uM":"772000.8357","27 MDA-MB-231 DMM 5 mM":"689520.3802","30 MDA-MB-231 DMM 5 mM":"840745.3169","29 MDA-MB-231 Combination":"546763.2996","32 MDA-MB-231 Combination":"506107.8698","04 MDA-MB-468 GSK 1 uM":"2231896.9270","07 MDA-MB-468 GSK 1 uM":"2163413.8810","03 MDA-MB-468 DMM 5 mM":"1532822.7050","06 MDA-MB-468 DMM 5 mM":"1715181.4320","05 MDA-MB-468 Combination":"1393542.9520","08 MDA-MB-468 Combination":"1787114.4740","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"940870.5763","13 SUM159PT GSK 1 uM":"1215701.1930","09 SUM159PT DMM 5 mM":"615733.9180","12 SUM159PT DMM 5 mM":"689119.4062","11 SUM159PT Combination":"534118.2266","14 SUM159PT Combination":"643273.4177"},{"Metabolite":"NADH 408","40 CAL120 GSK 1 uM":"1113305.5920","43 CAL120 GSK 1 uM":"910883.8503","39 CAL120 DMM 5 mM":"1020193.1910","42 CAL120 DMM 5 mM":"895395.4796","41 CAL120 Combination":"955508.8888","44 CAL120 Combination":"863715.0818","22 HCC1806 GSK 1 uM":"3290424.0700","25 HCC1806 GSK 1 uM":"4752694.6850","21 HCC1806 DMM 5 mM":"4174186.5810","24 HCC1806 DMM 5 mM":"2685994.9050","23 HCC1806 Combination":"2164240.9130","26 HCC1806 Combination":"2861557.1300","34 HS578T GSK 1 uM":"865477.1667","37 HS578T GSK 1 uM":"1187104.3440","33 HS578T DMM 5 mM":"1146947.1110","36 HS578T DMM 5 mM":"1041172.4720","35 HS578T Combination":"1294349.5920","38 HS578T Combination":"724320.5400","16 MCF7 GSK 1 uM":"1070353.5020","19 MCF7 GSK 1 uM":"1196065.1630","15 MCF7 DMM 5 mM":"948523.2666","18 MCF7 DMM 5 mM":"946044.2297","17 MCF7 Combination":"904898.7582","20 MCF7 Combination":"511799.4610","28 MDA-MB-231 GSK 1 uM":"2771600.9790","31 MDA-MB-231 GSK 1 uM":"2491501.7010","27 MDA-MB-231 DMM 5 mM":"2274026.1170","30 MDA-MB-231 DMM 5 mM":"2727186.6820","29 MDA-MB-231 Combination":"1846344.7450","32 MDA-MB-231 Combination":"1772651.0420","04 MDA-MB-468 GSK 1 uM":"7372759.0020","07 MDA-MB-468 GSK 1 uM":"6770292.6590","03 MDA-MB-468 DMM 5 mM":"4940206.5800","06 MDA-MB-468 DMM 5 mM":"5525909.9750","05 MDA-MB-468 Combination":"4464921.8040","08 MDA-MB-468 Combination":"5702009.4180","01 Blank":"311.1796","46 Blank":"343.2817","02 DMEM/F12 no adds":"476.0131","45 DMEM/F12 no adds":"247.2272","10 SUM159PT GSK 1 uM":"3022658.2170","13 SUM159PT GSK 1 uM":"3817699.5340","09 SUM159PT DMM 5 mM":"1954713.5760","12 SUM159PT DMM 5 mM":"2112450.0320","11 SUM159PT Combination":"1759728.3100","14 SUM159PT Combination":"2198097.9500"},{"Metabolite":"NADPH 328","40 CAL120 GSK 1 uM":"80247.8679","43 CAL120 GSK 1 uM":"66062.1646","39 CAL120 DMM 5 mM":"67784.4265","42 CAL120 DMM 5 mM":"62709.1516","41 CAL120 Combination":"63434.4293","44 CAL120 Combination":"60202.1529","22 HCC1806 GSK 1 uM":"150718.7276","25 HCC1806 GSK 1 uM":"134952.1191","21 HCC1806 DMM 5 mM":"67547.8363","24 HCC1806 DMM 5 mM":"126227.8872","23 HCC1806 Combination":"133484.0885","26 HCC1806 Combination":"128218.8170","34 HS578T GSK 1 uM":"26007.9676","37 HS578T GSK 1 uM":"28731.3326","33 HS578T DMM 5 mM":"21602.3199","36 HS578T DMM 5 mM":"20640.6074","35 HS578T Combination":"24609.1071","38 HS578T Combination":"20604.1963","16 MCF7 GSK 1 uM":"88590.6111","19 MCF7 GSK 1 uM":"91102.5673","15 MCF7 DMM 5 mM":"88817.2096","18 MCF7 DMM 5 mM":"69515.5970","17 MCF7 Combination":"90525.6076","20 MCF7 Combination":"44615.0437","28 MDA-MB-231 GSK 1 uM":"40521.8491","31 MDA-MB-231 GSK 1 uM":"39424.3705","27 MDA-MB-231 DMM 5 mM":"44134.3250","30 MDA-MB-231 DMM 5 mM":"39021.3383","29 MDA-MB-231 Combination":"26662.8824","32 MDA-MB-231 Combination":"30416.2045","04 MDA-MB-468 GSK 1 uM":"63660.8608","07 MDA-MB-468 GSK 1 uM":"75025.1065","03 MDA-MB-468 DMM 5 mM":"101003.3362","06 MDA-MB-468 DMM 5 mM":"62923.8426","05 MDA-MB-468 Combination":"87939.4768","08 MDA-MB-468 Combination":"30068.3263","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"94918.3611","13 SUM159PT GSK 1 uM":"101304.2540","09 SUM159PT DMM 5 mM":"93020.4231","12 SUM159PT DMM 5 mM":"109487.7299","11 SUM159PT Combination":"81593.3417","14 SUM159PT Combination":"96286.3136"},{"Metabolite":"NADPH 408","40 CAL120 GSK 1 uM":"367827.9590","43 CAL120 GSK 1 uM":"310306.6040","39 CAL120 DMM 5 mM":"289841.5450","42 CAL120 DMM 5 mM":"289055.1830","41 CAL120 Combination":"275522.1888","44 CAL120 Combination":"260032.6343","22 HCC1806 GSK 1 uM":"684954.0785","25 HCC1806 GSK 1 uM":"625122.7996","21 HCC1806 DMM 5 mM":"299992.5453","24 HCC1806 DMM 5 mM":"581911.2702","23 HCC1806 Combination":"602324.5186","26 HCC1806 Combination":"602490.6584","34 HS578T GSK 1 uM":"116295.6329","37 HS578T GSK 1 uM":"136308.6809","33 HS578T DMM 5 mM":"103479.8787","36 HS578T DMM 5 mM":"86113.4821","35 HS578T Combination":"114647.8939","38 HS578T Combination":"75139.7977","16 MCF7 GSK 1 uM":"371018.8535","19 MCF7 GSK 1 uM":"443201.9778","15 MCF7 DMM 5 mM":"391048.3049","18 MCF7 DMM 5 mM":"330714.3299","17 MCF7 Combination":"416540.5739","20 MCF7 Combination":"206564.0810","28 MDA-MB-231 GSK 1 uM":"189787.5838","31 MDA-MB-231 GSK 1 uM":"168341.0994","27 MDA-MB-231 DMM 5 mM":"190497.0289","30 MDA-MB-231 DMM 5 mM":"190817.5490","29 MDA-MB-231 Combination":"113297.5164","32 MDA-MB-231 Combination":"159169.5371","04 MDA-MB-468 GSK 1 uM":"271528.3319","07 MDA-MB-468 GSK 1 uM":"321303.1651","03 MDA-MB-468 DMM 5 mM":"461538.4864","06 MDA-MB-468 DMM 5 mM":"303831.5063","05 MDA-MB-468 Combination":"430479.1783","08 MDA-MB-468 Combination":"139688.1728","01 Blank":"188.7234","46 Blank":"207.7848","02 DMEM/F12 no adds":"43.7435","45 DMEM/F12 no adds":"399.1760","10 SUM159PT GSK 1 uM":"394105.2259","13 SUM159PT GSK 1 uM":"448415.6250","09 SUM159PT DMM 5 mM":"426875.9265","12 SUM159PT DMM 5 mM":"467886.1469","11 SUM159PT Combination":"377225.7592","14 SUM159PT Combination":"436625.3121"},{"Metabolite":"Octanoyl-CoA 79","40 CAL120 GSK 1 uM":"11420.8809","43 CAL120 GSK 1 uM":"2356.8893","39 CAL120 DMM 5 mM":"2468.7557","42 CAL120 DMM 5 mM":"2457.7661","41 CAL120 Combination":"6983.0179","44 CAL120 Combination":"2472.6834","22 HCC1806 GSK 1 uM":"2988.7577","25 HCC1806 GSK 1 uM":"3745.4697","21 HCC1806 DMM 5 mM":"5427.5812","24 HCC1806 DMM 5 mM":"14159.7926","23 HCC1806 Combination":"9264.5323","26 HCC1806 Combination":"8349.5313","34 HS578T GSK 1 uM":"1132.4547","37 HS578T GSK 1 uM":"3958.9043","33 HS578T DMM 5 mM":"6708.7692","36 HS578T DMM 5 mM":"3076.0785","35 HS578T Combination":"1061.8883","38 HS578T Combination":"1713.7859","16 MCF7 GSK 1 uM":"3931.9867","19 MCF7 GSK 1 uM":"7306.7089","15 MCF7 DMM 5 mM":"758.2563","18 MCF7 DMM 5 mM":"8020.0852","17 MCF7 Combination":"5031.4545","20 MCF7 Combination":"540.3146","28 MDA-MB-231 GSK 1 uM":"2993.4913","31 MDA-MB-231 GSK 1 uM":"7594.9212","27 MDA-MB-231 DMM 5 mM":"4256.8946","30 MDA-MB-231 DMM 5 mM":"4154.1643","29 MDA-MB-231 Combination":"2350.4952","32 MDA-MB-231 Combination":"6354.5751","04 MDA-MB-468 GSK 1 uM":"5188.5653","07 MDA-MB-468 GSK 1 uM":"6265.6191","03 MDA-MB-468 DMM 5 mM":"1617.0861","06 MDA-MB-468 DMM 5 mM":"1056.7576","05 MDA-MB-468 Combination":"4436.7853","08 MDA-MB-468 Combination":"2273.8053","01 Blank":"336.4414","46 Blank":"927.7614","02 DMEM/F12 no adds":"114.2798","45 DMEM/F12 no adds":"254.7215","10 SUM159PT GSK 1 uM":"7470.9903","13 SUM159PT GSK 1 uM":"6350.5118","09 SUM159PT DMM 5 mM":"8391.3972","12 SUM159PT DMM 5 mM":"8382.9201","11 SUM159PT Combination":"12768.4373","14 SUM159PT Combination":"19216.2749"},{"Metabolite":"Oleoyl-CoA (18:1) 79","40 CAL120 GSK 1 uM":"12253.7199","43 CAL120 GSK 1 uM":"14523.0015","39 CAL120 DMM 5 mM":"54480.9035","42 CAL120 DMM 5 mM":"50115.8691","41 CAL120 Combination":"34196.1484","44 CAL120 Combination":"25748.7360","22 HCC1806 GSK 1 uM":"12379.0054","25 HCC1806 GSK 1 uM":"14382.6059","21 HCC1806 DMM 5 mM":"24312.3545","24 HCC1806 DMM 5 mM":"22226.8191","23 HCC1806 Combination":"16849.8832","26 HCC1806 Combination":"20421.1304","34 HS578T GSK 1 uM":"18465.7454","37 HS578T GSK 1 uM":"10507.3882","33 HS578T DMM 5 mM":"26944.7564","36 HS578T DMM 5 mM":"19887.8005","35 HS578T Combination":"33096.6902","38 HS578T Combination":"16828.9186","16 MCF7 GSK 1 uM":"29593.7962","19 MCF7 GSK 1 uM":"20770.9710","15 MCF7 DMM 5 mM":"64579.3697","18 MCF7 DMM 5 mM":"65073.0373","17 MCF7 Combination":"29041.5271","20 MCF7 Combination":"19523.0974","28 MDA-MB-231 GSK 1 uM":"5260.9544","31 MDA-MB-231 GSK 1 uM":"5033.4985","27 MDA-MB-231 DMM 5 mM":"11884.6570","30 MDA-MB-231 DMM 5 mM":"8781.9481","29 MDA-MB-231 Combination":"3880.1700","32 MDA-MB-231 Combination":"5018.1806","04 MDA-MB-468 GSK 1 uM":"81982.4902","07 MDA-MB-468 GSK 1 uM":"53154.3088","03 MDA-MB-468 DMM 5 mM":"99606.6619","06 MDA-MB-468 DMM 5 mM":"111516.8291","05 MDA-MB-468 Combination":"46029.3536","08 MDA-MB-468 Combination":"87470.2562","01 Blank":"117.2437","46 Blank":"448.2902","02 DMEM/F12 no adds":"111.7691","45 DMEM/F12 no adds":"488.8829","10 SUM159PT GSK 1 uM":"18259.7605","13 SUM159PT GSK 1 uM":"24924.8242","09 SUM159PT DMM 5 mM":"45608.8957","12 SUM159PT DMM 5 mM":"73563.0169","11 SUM159PT Combination":"39854.9862","14 SUM159PT Combination":"43114.0550"},{"Metabolite":"O-Phospho-L-serine 79","40 CAL120 GSK 1 uM":"229067.0957","43 CAL120 GSK 1 uM":"240349.0785","39 CAL120 DMM 5 mM":"198013.0417","42 CAL120 DMM 5 mM":"216861.2551","41 CAL120 Combination":"205717.7273","44 CAL120 Combination":"193425.0367","22 HCC1806 GSK 1 uM":"220799.0399","25 HCC1806 GSK 1 uM":"208808.1753","21 HCC1806 DMM 5 mM":"249224.3071","24 HCC1806 DMM 5 mM":"291945.2098","23 HCC1806 Combination":"250802.3538","26 HCC1806 Combination":"258862.2864","34 HS578T GSK 1 uM":"208968.9601","37 HS578T GSK 1 uM":"187006.7676","33 HS578T DMM 5 mM":"156139.3762","36 HS578T DMM 5 mM":"168132.6243","35 HS578T Combination":"161538.1272","38 HS578T Combination":"2060.6752","16 MCF7 GSK 1 uM":"16194.6365","19 MCF7 GSK 1 uM":"18878.1948","15 MCF7 DMM 5 mM":"13971.1688","18 MCF7 DMM 5 mM":"13845.3981","17 MCF7 Combination":"18917.9349","20 MCF7 Combination":"12609.9456","28 MDA-MB-231 GSK 1 uM":"63744.8936","31 MDA-MB-231 GSK 1 uM":"57580.8844","27 MDA-MB-231 DMM 5 mM":"63244.6707","30 MDA-MB-231 DMM 5 mM":"49663.1781","29 MDA-MB-231 Combination":"62568.8982","32 MDA-MB-231 Combination":"68477.1393","04 MDA-MB-468 GSK 1 uM":"2090.5394","07 MDA-MB-468 GSK 1 uM":"2359.6644","03 MDA-MB-468 DMM 5 mM":"1835.3391","06 MDA-MB-468 DMM 5 mM":"3998.5505","05 MDA-MB-468 Combination":"5006.6672","08 MDA-MB-468 Combination":"8059.9225","01 Blank":"","46 Blank":"137.2196","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"492.5877","10 SUM159PT GSK 1 uM":"80666.9547","13 SUM159PT GSK 1 uM":"86472.2330","09 SUM159PT DMM 5 mM":"81491.9751","12 SUM159PT DMM 5 mM":"90371.0030","11 SUM159PT Combination":"74962.5987","14 SUM159PT Combination":"99615.1009"},{"Metabolite":"O-Phospho-L-serine 97","40 CAL120 GSK 1 uM":"260030.1207","43 CAL120 GSK 1 uM":"272577.6540","39 CAL120 DMM 5 mM":"222769.9791","42 CAL120 DMM 5 mM":"228151.7894","41 CAL120 Combination":"244210.1803","44 CAL120 Combination":"240545.0708","22 HCC1806 GSK 1 uM":"235092.5797","25 HCC1806 GSK 1 uM":"241034.5724","21 HCC1806 DMM 5 mM":"278681.3443","24 HCC1806 DMM 5 mM":"334436.7504","23 HCC1806 Combination":"265904.3730","26 HCC1806 Combination":"300070.5576","34 HS578T GSK 1 uM":"226545.5574","37 HS578T GSK 1 uM":"208346.9915","33 HS578T DMM 5 mM":"196848.3352","36 HS578T DMM 5 mM":"209328.2835","35 HS578T Combination":"212521.5111","38 HS578T Combination":"5192.0342","16 MCF7 GSK 1 uM":"22806.3676","19 MCF7 GSK 1 uM":"14857.2248","15 MCF7 DMM 5 mM":"11941.2647","18 MCF7 DMM 5 mM":"13317.5517","17 MCF7 Combination":"18530.6080","20 MCF7 Combination":"21658.0831","28 MDA-MB-231 GSK 1 uM":"65264.2578","31 MDA-MB-231 GSK 1 uM":"66406.5696","27 MDA-MB-231 DMM 5 mM":"64662.6030","30 MDA-MB-231 DMM 5 mM":"66448.5535","29 MDA-MB-231 Combination":"63823.7291","32 MDA-MB-231 Combination":"66803.0223","04 MDA-MB-468 GSK 1 uM":"7006.0446","07 MDA-MB-468 GSK 1 uM":"4122.8680","03 MDA-MB-468 DMM 5 mM":"4056.9222","06 MDA-MB-468 DMM 5 mM":"6354.6785","05 MDA-MB-468 Combination":"6715.3094","08 MDA-MB-468 Combination":"4012.6383","01 Blank":"1062.9667","46 Blank":"4260.6387","02 DMEM/F12 no adds":"969.9783","45 DMEM/F12 no adds":"1776.3500","10 SUM159PT GSK 1 uM":"83954.4776","13 SUM159PT GSK 1 uM":"97347.1587","09 SUM159PT DMM 5 mM":"85875.8289","12 SUM159PT DMM 5 mM":"89243.2185","11 SUM159PT Combination":"100645.7786","14 SUM159PT Combination":"96842.5739"},{"Metabolite":"Oxaloacetic 87","40 CAL120 GSK 1 uM":"33515.5063","43 CAL120 GSK 1 uM":"6861.3355","39 CAL120 DMM 5 mM":"10169.6997","42 CAL120 DMM 5 mM":"32517.2132","41 CAL120 Combination":"15333.3270","44 CAL120 Combination":"8844.6461","22 HCC1806 GSK 1 uM":"7099.6662","25 HCC1806 GSK 1 uM":"28161.7980","21 HCC1806 DMM 5 mM":"42744.0863","24 HCC1806 DMM 5 mM":"2328.7267","23 HCC1806 Combination":"13367.5238","26 HCC1806 Combination":"27345.6933","34 HS578T GSK 1 uM":"2886.2924","37 HS578T GSK 1 uM":"1524.1534","33 HS578T DMM 5 mM":"2261.8054","36 HS578T DMM 5 mM":"14697.1861","35 HS578T Combination":"811.8471","38 HS578T Combination":"352.1782","16 MCF7 GSK 1 uM":"15642.1835","19 MCF7 GSK 1 uM":"11545.3793","15 MCF7 DMM 5 mM":"26427.2579","18 MCF7 DMM 5 mM":"22314.1526","17 MCF7 Combination":"9247.2702","20 MCF7 Combination":"13932.1536","28 MDA-MB-231 GSK 1 uM":"18831.2215","31 MDA-MB-231 GSK 1 uM":"2311.3127","27 MDA-MB-231 DMM 5 mM":"6759.9011","30 MDA-MB-231 DMM 5 mM":"7470.8043","29 MDA-MB-231 Combination":"1768.1822","32 MDA-MB-231 Combination":"10264.7329","04 MDA-MB-468 GSK 1 uM":"13221.4702","07 MDA-MB-468 GSK 1 uM":"13776.4214","03 MDA-MB-468 DMM 5 mM":"11879.6025","06 MDA-MB-468 DMM 5 mM":"9706.1566","05 MDA-MB-468 Combination":"1258.6811","08 MDA-MB-468 Combination":"41498.8331","01 Blank":"1576.1362","46 Blank":"1134.9249","02 DMEM/F12 no adds":"4086.3141","45 DMEM/F12 no adds":"3294.0815","10 SUM159PT GSK 1 uM":"5990.4543","13 SUM159PT GSK 1 uM":"1306.5794","09 SUM159PT DMM 5 mM":"752.4749","12 SUM159PT DMM 5 mM":"33443.9967","11 SUM159PT Combination":"3798.6066","14 SUM159PT Combination":"170.0890"},{"Metabolite":"Palmitic PAR","40 CAL120 GSK 1 uM":"4489590.8450","43 CAL120 GSK 1 uM":"3933403.7900","39 CAL120 DMM 5 mM":"8272886.5380","42 CAL120 DMM 5 mM":"7891728.7180","41 CAL120 Combination":"5142349.2940","44 CAL120 Combination":"4774068.0660","22 HCC1806 GSK 1 uM":"2357772.2740","25 HCC1806 GSK 1 uM":"3333232.3740","21 HCC1806 DMM 5 mM":"7548210.9110","24 HCC1806 DMM 5 mM":"9744328.7790","23 HCC1806 Combination":"7226296.5560","26 HCC1806 Combination":"3106688.9030","34 HS578T GSK 1 uM":"4407990.1140","37 HS578T GSK 1 uM":"13206240.9000","33 HS578T DMM 5 mM":"5990178.8290","36 HS578T DMM 5 mM":"7716210.4220","35 HS578T Combination":"9150797.2290","38 HS578T Combination":"11812069.1400","16 MCF7 GSK 1 uM":"4340423.3130","19 MCF7 GSK 1 uM":"4105641.0740","15 MCF7 DMM 5 mM":"5757306.1800","18 MCF7 DMM 5 mM":"5533478.0120","17 MCF7 Combination":"4066281.9600","20 MCF7 Combination":"6697566.2120","28 MDA-MB-231 GSK 1 uM":"2497100.0200","31 MDA-MB-231 GSK 1 uM":"5682896.4270","27 MDA-MB-231 DMM 5 mM":"4444705.5620","30 MDA-MB-231 DMM 5 mM":"8207660.9160","29 MDA-MB-231 Combination":"6238815.2750","32 MDA-MB-231 Combination":"5823930.8410","04 MDA-MB-468 GSK 1 uM":"5596099.8750","07 MDA-MB-468 GSK 1 uM":"4398249.0420","03 MDA-MB-468 DMM 5 mM":"5800864.8720","06 MDA-MB-468 DMM 5 mM":"5480675.6370","05 MDA-MB-468 Combination":"5417368.9410","08 MDA-MB-468 Combination":"3906951.1860","01 Blank":"315477.5142","46 Blank":"382390.1832","02 DMEM/F12 no adds":"469749.7786","45 DMEM/F12 no adds":"467540.5824","10 SUM159PT GSK 1 uM":"5747724.8620","13 SUM159PT GSK 1 uM":"3388518.2720","09 SUM159PT DMM 5 mM":"5192395.1600","12 SUM159PT DMM 5 mM":"4559767.0220","11 SUM159PT Combination":"3654275.0770","14 SUM159PT Combination":"3744390.9050"},{"Metabolite":"Palmitoleic PAR","40 CAL120 GSK 1 uM":"966556.5739","43 CAL120 GSK 1 uM":"899299.5609","39 CAL120 DMM 5 mM":"708870.2281","42 CAL120 DMM 5 mM":"1008704.5690","41 CAL120 Combination":"1237724.2280","44 CAL120 Combination":"1095590.0960","22 HCC1806 GSK 1 uM":"494168.4119","25 HCC1806 GSK 1 uM":"503874.3498","21 HCC1806 DMM 5 mM":"1233309.6660","24 HCC1806 DMM 5 mM":"776247.5041","23 HCC1806 Combination":"747620.2761","26 HCC1806 Combination":"403287.2095","34 HS578T GSK 1 uM":"428605.4693","37 HS578T GSK 1 uM":"472979.1078","33 HS578T DMM 5 mM":"518384.5802","36 HS578T DMM 5 mM":"710514.4431","35 HS578T Combination":"811884.0287","38 HS578T Combination":"544423.0544","16 MCF7 GSK 1 uM":"778610.3283","19 MCF7 GSK 1 uM":"1964482.6050","15 MCF7 DMM 5 mM":"1476951.8540","18 MCF7 DMM 5 mM":"1661402.0970","17 MCF7 Combination":"631118.7889","20 MCF7 Combination":"1216316.5080","28 MDA-MB-231 GSK 1 uM":"267370.7204","31 MDA-MB-231 GSK 1 uM":"413759.5109","27 MDA-MB-231 DMM 5 mM":"601857.1464","30 MDA-MB-231 DMM 5 mM":"534366.6314","29 MDA-MB-231 Combination":"532943.0034","32 MDA-MB-231 Combination":"343264.1873","04 MDA-MB-468 GSK 1 uM":"1398327.4280","07 MDA-MB-468 GSK 1 uM":"667535.3195","03 MDA-MB-468 DMM 5 mM":"1305343.7080","06 MDA-MB-468 DMM 5 mM":"1158834.6070","05 MDA-MB-468 Combination":"830025.4731","08 MDA-MB-468 Combination":"1286560.7400","01 Blank":"10588.5058","46 Blank":"37404.5913","02 DMEM/F12 no adds":"60708.4860","45 DMEM/F12 no adds":"63135.8616","10 SUM159PT GSK 1 uM":"740782.9599","13 SUM159PT GSK 1 uM":"438579.8458","09 SUM159PT DMM 5 mM":"903156.7923","12 SUM159PT DMM 5 mM":"874246.1274","11 SUM159PT Combination":"748881.0740","14 SUM159PT Combination":"948243.1888"},{"Metabolite":"Palmitoleyl-CoA (16:1) 79","40 CAL120 GSK 1 uM":"4066.3058","43 CAL120 GSK 1 uM":"3977.8880","39 CAL120 DMM 5 mM":"13121.3067","42 CAL120 DMM 5 mM":"6557.7576","41 CAL120 Combination":"3606.2580","44 CAL120 Combination":"3973.0306","22 HCC1806 GSK 1 uM":"3358.9965","25 HCC1806 GSK 1 uM":"1373.6531","21 HCC1806 DMM 5 mM":"5513.7467","24 HCC1806 DMM 5 mM":"4943.4276","23 HCC1806 Combination":"1676.0555","26 HCC1806 Combination":"2523.5938","34 HS578T GSK 1 uM":"2322.8086","37 HS578T GSK 1 uM":"4020.2180","33 HS578T DMM 5 mM":"5030.8891","36 HS578T DMM 5 mM":"3977.2026","35 HS578T Combination":"6735.1022","38 HS578T Combination":"4391.9212","16 MCF7 GSK 1 uM":"5407.2522","19 MCF7 GSK 1 uM":"2943.4726","15 MCF7 DMM 5 mM":"28760.6773","18 MCF7 DMM 5 mM":"22312.7752","17 MCF7 Combination":"4732.0227","20 MCF7 Combination":"3967.0355","28 MDA-MB-231 GSK 1 uM":"1370.1567","31 MDA-MB-231 GSK 1 uM":"1725.1888","27 MDA-MB-231 DMM 5 mM":"2558.1110","30 MDA-MB-231 DMM 5 mM":"3455.7707","29 MDA-MB-231 Combination":"1212.5985","32 MDA-MB-231 Combination":"1605.2376","04 MDA-MB-468 GSK 1 uM":"18016.8483","07 MDA-MB-468 GSK 1 uM":"11678.9753","03 MDA-MB-468 DMM 5 mM":"40827.1703","06 MDA-MB-468 DMM 5 mM":"37910.5943","05 MDA-MB-468 Combination":"12947.7352","08 MDA-MB-468 Combination":"19410.5863","01 Blank":"223.1995","46 Blank":"238.0096","02 DMEM/F12 no adds":"448.2661","45 DMEM/F12 no adds":"590.4808","10 SUM159PT GSK 1 uM":"2003.8023","13 SUM159PT GSK 1 uM":"1405.3959","09 SUM159PT DMM 5 mM":"9583.8290","12 SUM159PT DMM 5 mM":"14429.2115","11 SUM159PT Combination":"4617.6072","14 SUM159PT Combination":"5564.6248"},{"Metabolite":"Palmitoyl-CoA (16:0) 79","40 CAL120 GSK 1 uM":"4958.1448","43 CAL120 GSK 1 uM":"6150.1756","39 CAL120 DMM 5 mM":"36408.6005","42 CAL120 DMM 5 mM":"26205.6561","41 CAL120 Combination":"8121.9911","44 CAL120 Combination":"7168.0236","22 HCC1806 GSK 1 uM":"4938.4788","25 HCC1806 GSK 1 uM":"4032.2186","21 HCC1806 DMM 5 mM":"45563.4358","24 HCC1806 DMM 5 mM":"54571.8134","23 HCC1806 Combination":"4661.7978","26 HCC1806 Combination":"8972.1979","34 HS578T GSK 1 uM":"6145.3442","37 HS578T GSK 1 uM":"4311.2671","33 HS578T DMM 5 mM":"7792.8440","36 HS578T DMM 5 mM":"9435.1045","35 HS578T Combination":"9765.6595","38 HS578T Combination":"5792.7622","16 MCF7 GSK 1 uM":"3888.1030","19 MCF7 GSK 1 uM":"1605.1634","15 MCF7 DMM 5 mM":"47969.2623","18 MCF7 DMM 5 mM":"32940.3418","17 MCF7 Combination":"5584.8319","20 MCF7 Combination":"3494.8920","28 MDA-MB-231 GSK 1 uM":"2973.2781","31 MDA-MB-231 GSK 1 uM":"2164.1307","27 MDA-MB-231 DMM 5 mM":"11435.1580","30 MDA-MB-231 DMM 5 mM":"7580.5442","29 MDA-MB-231 Combination":"2015.3756","32 MDA-MB-231 Combination":"4571.4688","04 MDA-MB-468 GSK 1 uM":"11441.3972","07 MDA-MB-468 GSK 1 uM":"10781.9147","03 MDA-MB-468 DMM 5 mM":"59653.9813","06 MDA-MB-468 DMM 5 mM":"71929.8735","05 MDA-MB-468 Combination":"17595.3156","08 MDA-MB-468 Combination":"25021.5681","01 Blank":"118.4797","46 Blank":"593.2367","02 DMEM/F12 no adds":"219.3363","45 DMEM/F12 no adds":"970.1993","10 SUM159PT GSK 1 uM":"3567.7605","13 SUM159PT GSK 1 uM":"1723.6629","09 SUM159PT DMM 5 mM":"13652.2891","12 SUM159PT DMM 5 mM":"25177.2062","11 SUM159PT Combination":"2765.3107","14 SUM159PT Combination":"4224.0097"},{"Metabolite":"Pemetrexed 297","40 CAL120 GSK 1 uM":"1069.5342","43 CAL120 GSK 1 uM":"215.3342","39 CAL120 DMM 5 mM":"214.9903","42 CAL120 DMM 5 mM":"839.6495","41 CAL120 Combination":"2538.5127","44 CAL120 Combination":"1239.8884","22 HCC1806 GSK 1 uM":"858.4326","25 HCC1806 GSK 1 uM":"253.6222","21 HCC1806 DMM 5 mM":"196.9564","24 HCC1806 DMM 5 mM":"449.4867","23 HCC1806 Combination":"","26 HCC1806 Combination":"216.3488","34 HS578T GSK 1 uM":"565.8704","37 HS578T GSK 1 uM":"1060.2104","33 HS578T DMM 5 mM":"2718.0748","36 HS578T DMM 5 mM":"1882.1361","35 HS578T Combination":"219.7629","38 HS578T Combination":"3192.4394","16 MCF7 GSK 1 uM":"1254.8120","19 MCF7 GSK 1 uM":"213.8343","15 MCF7 DMM 5 mM":"836.2652","18 MCF7 DMM 5 mM":"848.4260","17 MCF7 Combination":"1928.7327","20 MCF7 Combination":"1630.6552","28 MDA-MB-231 GSK 1 uM":"1335.5358","31 MDA-MB-231 GSK 1 uM":"1023.0708","27 MDA-MB-231 DMM 5 mM":"1033.8437","30 MDA-MB-231 DMM 5 mM":"","29 MDA-MB-231 Combination":"504.9099","32 MDA-MB-231 Combination":"1282.4785","04 MDA-MB-468 GSK 1 uM":"1735.3263","07 MDA-MB-468 GSK 1 uM":"","03 MDA-MB-468 DMM 5 mM":"221.4736","06 MDA-MB-468 DMM 5 mM":"226.9091","05 MDA-MB-468 Combination":"593.9016","08 MDA-MB-468 Combination":"440.1062","01 Blank":"1253.5705","46 Blank":"2963.1926","02 DMEM/F12 no adds":"566.4617","45 DMEM/F12 no adds":"605.1247","10 SUM159PT GSK 1 uM":"482.6589","13 SUM159PT GSK 1 uM":"213.4408","09 SUM159PT DMM 5 mM":"623.6106","12 SUM159PT DMM 5 mM":"862.3253","11 SUM159PT Combination":"222.7116","14 SUM159PT Combination":"1272.2198"},{"Metabolite":"Pemetrexed 321","40 CAL120 GSK 1 uM":"","43 CAL120 GSK 1 uM":"","39 CAL120 DMM 5 mM":"","42 CAL120 DMM 5 mM":"","41 CAL120 Combination":"419.2197","44 CAL120 Combination":"","22 HCC1806 GSK 1 uM":"","25 HCC1806 GSK 1 uM":"","21 HCC1806 DMM 5 mM":"","24 HCC1806 DMM 5 mM":"","23 HCC1806 Combination":"","26 HCC1806 Combination":"","34 HS578T GSK 1 uM":"","37 HS578T GSK 1 uM":"","33 HS578T DMM 5 mM":"","36 HS578T DMM 5 mM":"","35 HS578T Combination":"","38 HS578T Combination":"439.0889","16 MCF7 GSK 1 uM":"","19 MCF7 GSK 1 uM":"","15 MCF7 DMM 5 mM":"226.9489","18 MCF7 DMM 5 mM":"","17 MCF7 Combination":"","20 MCF7 Combination":"","28 MDA-MB-231 GSK 1 uM":"","31 MDA-MB-231 GSK 1 uM":"","27 MDA-MB-231 DMM 5 mM":"","30 MDA-MB-231 DMM 5 mM":"","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"216.7901","04 MDA-MB-468 GSK 1 uM":"","07 MDA-MB-468 GSK 1 uM":"","03 MDA-MB-468 DMM 5 mM":"","06 MDA-MB-468 DMM 5 mM":"","05 MDA-MB-468 Combination":"","08 MDA-MB-468 Combination":"","01 Blank":"347.5544","46 Blank":"177.0994","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"","13 SUM159PT GSK 1 uM":"","09 SUM159PT DMM 5 mM":"","12 SUM159PT DMM 5 mM":"","11 SUM159PT Combination":"","14 SUM159PT Combination":""},{"Metabolite":"Penicillin G 289","40 CAL120 GSK 1 uM":"1205969.7560","43 CAL120 GSK 1 uM":"904882.0606","39 CAL120 DMM 5 mM":"2503571.8900","42 CAL120 DMM 5 mM":"1139403.8880","41 CAL120 Combination":"1107382.4950","44 CAL120 Combination":"542388.9580","22 HCC1806 GSK 1 uM":"3223413.3640","25 HCC1806 GSK 1 uM":"2482291.4560","21 HCC1806 DMM 5 mM":"5400384.1930","24 HCC1806 DMM 5 mM":"1922019.7970","23 HCC1806 Combination":"1294106.8750","26 HCC1806 Combination":"1677129.6720","34 HS578T GSK 1 uM":"747458.8622","37 HS578T GSK 1 uM":"2049329.1700","33 HS578T DMM 5 mM":"1531586.6280","36 HS578T DMM 5 mM":"979650.2280","35 HS578T Combination":"1481192.9110","38 HS578T Combination":"600972.2934","16 MCF7 GSK 1 uM":"1902931.2480","19 MCF7 GSK 1 uM":"1181487.3670","15 MCF7 DMM 5 mM":"1816254.7820","18 MCF7 DMM 5 mM":"2884014.5500","17 MCF7 Combination":"1175115.7550","20 MCF7 Combination":"679068.2151","28 MDA-MB-231 GSK 1 uM":"2219219.8370","31 MDA-MB-231 GSK 1 uM":"1882719.4690","27 MDA-MB-231 DMM 5 mM":"2032984.4570","30 MDA-MB-231 DMM 5 mM":"2732922.0260","29 MDA-MB-231 Combination":"1834485.7560","32 MDA-MB-231 Combination":"1229414.6250","04 MDA-MB-468 GSK 1 uM":"7667277.1180","07 MDA-MB-468 GSK 1 uM":"8472572.4950","03 MDA-MB-468 DMM 5 mM":"9544445.0590","06 MDA-MB-468 DMM 5 mM":"7479072.8690","05 MDA-MB-468 Combination":"4177908.0770","08 MDA-MB-468 Combination":"6811842.5530","01 Blank":"7825.3568","46 Blank":"11040.3093","02 DMEM/F12 no adds":"2262.4697","45 DMEM/F12 no adds":"6824.9023","10 SUM159PT GSK 1 uM":"1244500.7450","13 SUM159PT GSK 1 uM":"936378.1760","09 SUM159PT DMM 5 mM":"1239405.2850","12 SUM159PT DMM 5 mM":"735712.5869","11 SUM159PT Combination":"801698.8123","14 SUM159PT Combination":"1027680.2580"},{"Metabolite":"Phenol Red 195","40 CAL120 GSK 1 uM":"76257.2790","43 CAL120 GSK 1 uM":"21041.4157","39 CAL120 DMM 5 mM":"166663.6402","42 CAL120 DMM 5 mM":"73484.1275","41 CAL120 Combination":"26882.4287","44 CAL120 Combination":"20342.6561","22 HCC1806 GSK 1 uM":"79526.4421","25 HCC1806 GSK 1 uM":"44314.8299","21 HCC1806 DMM 5 mM":"216549.9723","24 HCC1806 DMM 5 mM":"59427.7898","23 HCC1806 Combination":"23696.8475","26 HCC1806 Combination":"35408.4584","34 HS578T GSK 1 uM":"8020.1405","37 HS578T GSK 1 uM":"15699.6706","33 HS578T DMM 5 mM":"43129.7417","36 HS578T DMM 5 mM":"24574.5568","35 HS578T Combination":"91739.4620","38 HS578T Combination":"4740.7741","16 MCF7 GSK 1 uM":"100295.4304","19 MCF7 GSK 1 uM":"65032.3802","15 MCF7 DMM 5 mM":"33035.0593","18 MCF7 DMM 5 mM":"94250.2607","17 MCF7 Combination":"26603.4932","20 MCF7 Combination":"18603.4885","28 MDA-MB-231 GSK 1 uM":"77508.8358","31 MDA-MB-231 GSK 1 uM":"17801.8824","27 MDA-MB-231 DMM 5 mM":"63589.1675","30 MDA-MB-231 DMM 5 mM":"58211.4026","29 MDA-MB-231 Combination":"40689.5865","32 MDA-MB-231 Combination":"36992.8266","04 MDA-MB-468 GSK 1 uM":"222189.8149","07 MDA-MB-468 GSK 1 uM":"184132.6876","03 MDA-MB-468 DMM 5 mM":"676687.6907","06 MDA-MB-468 DMM 5 mM":"477622.9913","05 MDA-MB-468 Combination":"128864.2824","08 MDA-MB-468 Combination":"516444.2297","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"13336244.3700","45 DMEM/F12 no adds":"12353842.2400","10 SUM159PT GSK 1 uM":"13772.7310","13 SUM159PT GSK 1 uM":"23319.6270","09 SUM159PT DMM 5 mM":"17133.9050","12 SUM159PT DMM 5 mM":"56971.4148","11 SUM159PT Combination":"23784.2659","14 SUM159PT Combination":"24323.6037"},{"Metabolite":"Phenol Red 93","40 CAL120 GSK 1 uM":"139631.2572","43 CAL120 GSK 1 uM":"98876.3373","39 CAL120 DMM 5 mM":"295500.0531","42 CAL120 DMM 5 mM":"115293.9676","41 CAL120 Combination":"125179.9450","44 CAL120 Combination":"85285.6502","22 HCC1806 GSK 1 uM":"357634.2048","25 HCC1806 GSK 1 uM":"273244.5596","21 HCC1806 DMM 5 mM":"771259.7372","24 HCC1806 DMM 5 mM":"274607.1581","23 HCC1806 Combination":"145004.2690","26 HCC1806 Combination":"198091.5632","34 HS578T GSK 1 uM":"100771.6631","37 HS578T GSK 1 uM":"268105.8160","33 HS578T DMM 5 mM":"183919.3835","36 HS578T DMM 5 mM":"105247.1883","35 HS578T Combination":"172216.0782","38 HS578T Combination":"59474.9090","16 MCF7 GSK 1 uM":"240330.3519","19 MCF7 GSK 1 uM":"127912.4968","15 MCF7 DMM 5 mM":"200372.0701","18 MCF7 DMM 5 mM":"367238.1134","17 MCF7 Combination":"239591.9381","20 MCF7 Combination":"101718.1744","28 MDA-MB-231 GSK 1 uM":"248024.2239","31 MDA-MB-231 GSK 1 uM":"246424.7535","27 MDA-MB-231 DMM 5 mM":"241892.1420","30 MDA-MB-231 DMM 5 mM":"345824.4794","29 MDA-MB-231 Combination":"224280.2415","32 MDA-MB-231 Combination":"169207.1547","04 MDA-MB-468 GSK 1 uM":"825510.8985","07 MDA-MB-468 GSK 1 uM":"954703.3522","03 MDA-MB-468 DMM 5 mM":"1254672.4090","06 MDA-MB-468 DMM 5 mM":"939081.7467","05 MDA-MB-468 Combination":"627241.9232","08 MDA-MB-468 Combination":"1048963.5170","01 Blank":"319.9343","46 Blank":"394.9703","02 DMEM/F12 no adds":"19595278.0700","45 DMEM/F12 no adds":"20110542.9200","10 SUM159PT GSK 1 uM":"145218.7193","13 SUM159PT GSK 1 uM":"137781.9328","09 SUM159PT DMM 5 mM":"165917.5121","12 SUM159PT DMM 5 mM":"102133.6468","11 SUM159PT Combination":"119237.6397","14 SUM159PT Combination":"114394.2014"},{"Metabolite":"Phenylalanine 147","40 CAL120 GSK 1 uM":"2547480.8910","43 CAL120 GSK 1 uM":"2514910.1070","39 CAL120 DMM 5 mM":"3247329.3230","42 CAL120 DMM 5 mM":"2518507.6410","41 CAL120 Combination":"2544735.8430","44 CAL120 Combination":"2367796.4880","22 HCC1806 GSK 1 uM":"8765024.9820","25 HCC1806 GSK 1 uM":"8155560.2400","21 HCC1806 DMM 5 mM":"12991003.9800","24 HCC1806 DMM 5 mM":"11494303.5700","23 HCC1806 Combination":"12074792.0700","26 HCC1806 Combination":"12501581.2400","34 HS578T GSK 1 uM":"3679994.0560","37 HS578T GSK 1 uM":"4166410.5320","33 HS578T DMM 5 mM":"3241766.7250","36 HS578T DMM 5 mM":"2991860.7750","35 HS578T Combination":"3635661.7950","38 HS578T Combination":"2769876.3690","16 MCF7 GSK 1 uM":"3707013.0900","19 MCF7 GSK 1 uM":"4997668.1280","15 MCF7 DMM 5 mM":"5125025.5880","18 MCF7 DMM 5 mM":"5623652.0960","17 MCF7 Combination":"4565219.6780","20 MCF7 Combination":"2698629.3210","28 MDA-MB-231 GSK 1 uM":"2607349.3680","31 MDA-MB-231 GSK 1 uM":"2637961.3640","27 MDA-MB-231 DMM 5 mM":"2678805.6850","30 MDA-MB-231 DMM 5 mM":"2849798.9680","29 MDA-MB-231 Combination":"2614958.2340","32 MDA-MB-231 Combination":"2567790.8130","04 MDA-MB-468 GSK 1 uM":"5352504.3800","07 MDA-MB-468 GSK 1 uM":"5380734.6550","03 MDA-MB-468 DMM 5 mM":"6532482.1710","06 MDA-MB-468 DMM 5 mM":"6404596.1830","05 MDA-MB-468 Combination":"5611389.3250","08 MDA-MB-468 Combination":"6694808.6630","01 Blank":"680.9859","46 Blank":"1076.7634","02 DMEM/F12 no adds":"19461398.3900","45 DMEM/F12 no adds":"20197262.0500","10 SUM159PT GSK 1 uM":"2936869.2740","13 SUM159PT GSK 1 uM":"3567182.8810","09 SUM159PT DMM 5 mM":"3154014.2070","12 SUM159PT DMM 5 mM":"3197118.8260","11 SUM159PT Combination":"3050266.3560","14 SUM159PT Combination":"3399648.4290"},{"Metabolite":"Phenylalanine 72","40 CAL120 GSK 1 uM":"1133197.8680","43 CAL120 GSK 1 uM":"1133431.3590","39 CAL120 DMM 5 mM":"1409316.1030","42 CAL120 DMM 5 mM":"1129095.3670","41 CAL120 Combination":"1106559.9200","44 CAL120 Combination":"1138276.2770","22 HCC1806 GSK 1 uM":"3823560.7460","25 HCC1806 GSK 1 uM":"3592072.6900","21 HCC1806 DMM 5 mM":"5734800.0100","24 HCC1806 DMM 5 mM":"5157004.6000","23 HCC1806 Combination":"5378117.1020","26 HCC1806 Combination":"5434952.9610","34 HS578T GSK 1 uM":"1666655.1620","37 HS578T GSK 1 uM":"1815199.3140","33 HS578T DMM 5 mM":"1418384.6310","36 HS578T DMM 5 mM":"1370286.5100","35 HS578T Combination":"1626793.9670","38 HS578T Combination":"1269077.9660","16 MCF7 GSK 1 uM":"1761302.6200","19 MCF7 GSK 1 uM":"2210993.9230","15 MCF7 DMM 5 mM":"2322227.0320","18 MCF7 DMM 5 mM":"2505150.0150","17 MCF7 Combination":"2066749.6260","20 MCF7 Combination":"1200939.7030","28 MDA-MB-231 GSK 1 uM":"1188666.4770","31 MDA-MB-231 GSK 1 uM":"1218084.2590","27 MDA-MB-231 DMM 5 mM":"1236427.2180","30 MDA-MB-231 DMM 5 mM":"1244447.2880","29 MDA-MB-231 Combination":"1119590.0970","32 MDA-MB-231 Combination":"1141287.8060","04 MDA-MB-468 GSK 1 uM":"2349351.7010","07 MDA-MB-468 GSK 1 uM":"2414762.3810","03 MDA-MB-468 DMM 5 mM":"2938788.6350","06 MDA-MB-468 DMM 5 mM":"2823149.0850","05 MDA-MB-468 Combination":"2494056.5610","08 MDA-MB-468 Combination":"2959082.6440","01 Blank":"","46 Blank":"721.3012","02 DMEM/F12 no adds":"8683680.4430","45 DMEM/F12 no adds":"9314798.9460","10 SUM159PT GSK 1 uM":"1332307.3470","13 SUM159PT GSK 1 uM":"1657035.6470","09 SUM159PT DMM 5 mM":"1498453.6410","12 SUM159PT DMM 5 mM":"1383804.8130","11 SUM159PT Combination":"1399451.2470","14 SUM159PT Combination":"1604314.3950"},{"Metabolite":"Propionic PAR","40 CAL120 GSK 1 uM":"37355.0512","43 CAL120 GSK 1 uM":"","39 CAL120 DMM 5 mM":"12154.9165","42 CAL120 DMM 5 mM":"4012.9565","41 CAL120 Combination":"20236.9035","44 CAL120 Combination":"279054.8585","22 HCC1806 GSK 1 uM":"543224.3274","25 HCC1806 GSK 1 uM":"","21 HCC1806 DMM 5 mM":"7522.0040","24 HCC1806 DMM 5 mM":"61833.0130","23 HCC1806 Combination":"96655.9270","26 HCC1806 Combination":"11266.9890","34 HS578T GSK 1 uM":"","37 HS578T GSK 1 uM":"63698.0891","33 HS578T DMM 5 mM":"","36 HS578T DMM 5 mM":"13837.4055","35 HS578T Combination":"29469.5085","38 HS578T Combination":"30493.3955","16 MCF7 GSK 1 uM":"282841.8824","19 MCF7 GSK 1 uM":"283725.2721","15 MCF7 DMM 5 mM":"92944.4705","18 MCF7 DMM 5 mM":"27306.6465","17 MCF7 Combination":"17190.0780","20 MCF7 Combination":"8560.2960","28 MDA-MB-231 GSK 1 uM":"","31 MDA-MB-231 GSK 1 uM":"","27 MDA-MB-231 DMM 5 mM":"20159.7145","30 MDA-MB-231 DMM 5 mM":"39693.4195","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"","04 MDA-MB-468 GSK 1 uM":"","07 MDA-MB-468 GSK 1 uM":"1024868.3200","03 MDA-MB-468 DMM 5 mM":"180873.2180","06 MDA-MB-468 DMM 5 mM":"37956.1100","05 MDA-MB-468 Combination":"297527.8870","08 MDA-MB-468 Combination":"45096.3010","01 Blank":"36525.2660","46 Blank":"764571.4526","02 DMEM/F12 no adds":"23059.8520","45 DMEM/F12 no adds":"2722082.4830","10 SUM159PT GSK 1 uM":"","13 SUM159PT GSK 1 uM":"331809.9363","09 SUM159PT DMM 5 mM":"23818.7060","12 SUM159PT DMM 5 mM":"78584.5380","11 SUM159PT Combination":"10398.1820","14 SUM159PT Combination":"28176.3325"},{"Metabolite":"Propionyl-CoA 408","40 CAL120 GSK 1 uM":"7927.2105","43 CAL120 GSK 1 uM":"17162.9804","39 CAL120 DMM 5 mM":"12022.3134","42 CAL120 DMM 5 mM":"8253.8312","41 CAL120 Combination":"17271.9391","44 CAL120 Combination":"18094.4846","22 HCC1806 GSK 1 uM":"8521.1317","25 HCC1806 GSK 1 uM":"8704.4226","21 HCC1806 DMM 5 mM":"4019.8964","24 HCC1806 DMM 5 mM":"5885.7946","23 HCC1806 Combination":"5103.1109","26 HCC1806 Combination":"4639.7011","34 HS578T GSK 1 uM":"3972.4314","37 HS578T GSK 1 uM":"1792.5729","33 HS578T DMM 5 mM":"2595.1258","36 HS578T DMM 5 mM":"675.2232","35 HS578T Combination":"4213.1117","38 HS578T Combination":"1139.9294","16 MCF7 GSK 1 uM":"4333.4417","19 MCF7 GSK 1 uM":"6938.5636","15 MCF7 DMM 5 mM":"6603.3559","18 MCF7 DMM 5 mM":"5128.3031","17 MCF7 Combination":"18254.3945","20 MCF7 Combination":"8999.4665","28 MDA-MB-231 GSK 1 uM":"5055.0167","31 MDA-MB-231 GSK 1 uM":"6079.3797","27 MDA-MB-231 DMM 5 mM":"8972.6885","30 MDA-MB-231 DMM 5 mM":"5712.5397","29 MDA-MB-231 Combination":"2998.7243","32 MDA-MB-231 Combination":"5773.9498","04 MDA-MB-468 GSK 1 uM":"29419.7182","07 MDA-MB-468 GSK 1 uM":"33553.6770","03 MDA-MB-468 DMM 5 mM":"30294.2861","06 MDA-MB-468 DMM 5 mM":"33295.5834","05 MDA-MB-468 Combination":"52110.7161","08 MDA-MB-468 Combination":"45852.2505","01 Blank":"485.8567","46 Blank":"77.8784","02 DMEM/F12 no adds":"432.0445","45 DMEM/F12 no adds":"584.6895","10 SUM159PT GSK 1 uM":"4586.0300","13 SUM159PT GSK 1 uM":"5112.1414","09 SUM159PT DMM 5 mM":"3323.8450","12 SUM159PT DMM 5 mM":"6126.4651","11 SUM159PT Combination":"7389.4086","14 SUM159PT Combination":"10833.2277"},{"Metabolite":"Pyroglutamic 82","40 CAL120 GSK 1 uM":"2121038.2880","43 CAL120 GSK 1 uM":"1984185.2260","39 CAL120 DMM 5 mM":"2746992.0440","42 CAL120 DMM 5 mM":"2205705.4340","41 CAL120 Combination":"2197801.9250","44 CAL120 Combination":"1996850.8550","22 HCC1806 GSK 1 uM":"4761517.6760","25 HCC1806 GSK 1 uM":"4231093.9730","21 HCC1806 DMM 5 mM":"5958955.7880","24 HCC1806 DMM 5 mM":"4471530.4350","23 HCC1806 Combination":"3910012.6920","26 HCC1806 Combination":"4016414.2020","34 HS578T GSK 1 uM":"1444158.2680","37 HS578T GSK 1 uM":"2023206.9960","33 HS578T DMM 5 mM":"1824131.8440","36 HS578T DMM 5 mM":"1572506.8780","35 HS578T Combination":"1972498.3390","38 HS578T Combination":"1370122.5600","16 MCF7 GSK 1 uM":"3412135.4080","19 MCF7 GSK 1 uM":"3667637.0420","15 MCF7 DMM 5 mM":"3983473.7390","18 MCF7 DMM 5 mM":"4875724.2720","17 MCF7 Combination":"3538068.5690","20 MCF7 Combination":"2334962.4150","28 MDA-MB-231 GSK 1 uM":"3374001.7520","31 MDA-MB-231 GSK 1 uM":"3361662.9220","27 MDA-MB-231 DMM 5 mM":"3922249.9510","30 MDA-MB-231 DMM 5 mM":"4315225.4300","29 MDA-MB-231 Combination":"3468862.3390","32 MDA-MB-231 Combination":"3205375.5060","04 MDA-MB-468 GSK 1 uM":"9189062.2030","07 MDA-MB-468 GSK 1 uM":"9091661.0730","03 MDA-MB-468 DMM 5 mM":"9431504.6300","06 MDA-MB-468 DMM 5 mM":"8788758.3010","05 MDA-MB-468 Combination":"7227909.2370","08 MDA-MB-468 Combination":"9096350.1020","01 Blank":"2784.6556","46 Blank":"2285.1059","02 DMEM/F12 no adds":"4040443.0420","45 DMEM/F12 no adds":"4510006.5160","10 SUM159PT GSK 1 uM":"2983313.9580","13 SUM159PT GSK 1 uM":"3179350.3460","09 SUM159PT DMM 5 mM":"3423200.8450","12 SUM159PT DMM 5 mM":"2774414.9830","11 SUM159PT Combination":"2792724.4470","14 SUM159PT Combination":"3249888.0920"},{"Metabolite":"Pyruvic 32","40 CAL120 GSK 1 uM":"518819.3174","43 CAL120 GSK 1 uM":"537272.9320","39 CAL120 DMM 5 mM":"615045.8308","42 CAL120 DMM 5 mM":"480771.4175","41 CAL120 Combination":"386004.0292","44 CAL120 Combination":"308816.8130","22 HCC1806 GSK 1 uM":"1777084.1600","25 HCC1806 GSK 1 uM":"1418292.5160","21 HCC1806 DMM 5 mM":"1810230.0340","24 HCC1806 DMM 5 mM":"1209152.8260","23 HCC1806 Combination":"858757.4823","26 HCC1806 Combination":"1003288.2570","34 HS578T GSK 1 uM":"147699.2894","37 HS578T GSK 1 uM":"194650.3845","33 HS578T DMM 5 mM":"132816.1990","36 HS578T DMM 5 mM":"91191.6530","35 HS578T Combination":"116130.7085","38 HS578T Combination":"88836.6985","16 MCF7 GSK 1 uM":"867145.6445","19 MCF7 GSK 1 uM":"955715.0977","15 MCF7 DMM 5 mM":"922942.5071","18 MCF7 DMM 5 mM":"1214468.3230","17 MCF7 Combination":"599766.1830","20 MCF7 Combination":"391797.0045","28 MDA-MB-231 GSK 1 uM":"421522.0199","31 MDA-MB-231 GSK 1 uM":"315122.2827","27 MDA-MB-231 DMM 5 mM":"525914.6510","30 MDA-MB-231 DMM 5 mM":"500066.3540","29 MDA-MB-231 Combination":"275314.5581","32 MDA-MB-231 Combination":"327150.3405","04 MDA-MB-468 GSK 1 uM":"2082800.9340","07 MDA-MB-468 GSK 1 uM":"2595824.7940","03 MDA-MB-468 DMM 5 mM":"2256047.5700","06 MDA-MB-468 DMM 5 mM":"2036048.1230","05 MDA-MB-468 Combination":"1403565.9980","08 MDA-MB-468 Combination":"2008070.9270","01 Blank":"19064.5920","46 Blank":"25483.3885","02 DMEM/F12 no adds":"4602057.6090","45 DMEM/F12 no adds":"4587013.6390","10 SUM159PT GSK 1 uM":"252052.9970","13 SUM159PT GSK 1 uM":"346663.1489","09 SUM159PT DMM 5 mM":"496879.4209","12 SUM159PT DMM 5 mM":"433744.9677","11 SUM159PT Combination":"369590.9415","14 SUM159PT Combination":"371777.3778"},{"Metabolite":"Riboflavin 243","40 CAL120 GSK 1 uM":"1071.5802","43 CAL120 GSK 1 uM":"1891.2002","39 CAL120 DMM 5 mM":"942.4905","42 CAL120 DMM 5 mM":"1022.7014","41 CAL120 Combination":"1625.2332","44 CAL120 Combination":"1211.1527","22 HCC1806 GSK 1 uM":"1619.2113","25 HCC1806 GSK 1 uM":"2276.7464","21 HCC1806 DMM 5 mM":"3035.3638","24 HCC1806 DMM 5 mM":"1603.0464","23 HCC1806 Combination":"1611.5790","26 HCC1806 Combination":"1606.8247","34 HS578T GSK 1 uM":"983.1133","37 HS578T GSK 1 uM":"543.9788","33 HS578T DMM 5 mM":"820.3071","36 HS578T DMM 5 mM":"1665.4217","35 HS578T Combination":"670.9776","38 HS578T Combination":"1522.9620","16 MCF7 GSK 1 uM":"1329.0440","19 MCF7 GSK 1 uM":"1209.9719","15 MCF7 DMM 5 mM":"1191.5897","18 MCF7 DMM 5 mM":"2101.0963","17 MCF7 Combination":"3251.4790","20 MCF7 Combination":"1207.2767","28 MDA-MB-231 GSK 1 uM":"1064.0798","31 MDA-MB-231 GSK 1 uM":"933.1520","27 MDA-MB-231 DMM 5 mM":"930.7291","30 MDA-MB-231 DMM 5 mM":"2152.0684","29 MDA-MB-231 Combination":"1083.3578","32 MDA-MB-231 Combination":"935.6035","04 MDA-MB-468 GSK 1 uM":"5011.7180","07 MDA-MB-468 GSK 1 uM":"7871.5937","03 MDA-MB-468 DMM 5 mM":"6365.6667","06 MDA-MB-468 DMM 5 mM":"2772.8156","05 MDA-MB-468 Combination":"5247.3261","08 MDA-MB-468 Combination":"4400.7141","01 Blank":"660.8090","46 Blank":"796.3701","02 DMEM/F12 no adds":"13480.8995","45 DMEM/F12 no adds":"9790.4523","10 SUM159PT GSK 1 uM":"1871.4606","13 SUM159PT GSK 1 uM":"935.8831","09 SUM159PT DMM 5 mM":"803.3425","12 SUM159PT DMM 5 mM":"671.1408","11 SUM159PT Combination":"1193.9854","14 SUM159PT Combination":"1066.9438"},{"Metabolite":"Sorbitol 71","40 CAL120 GSK 1 uM":"1160101.9920","43 CAL120 GSK 1 uM":"979289.8077","39 CAL120 DMM 5 mM":"360886.0864","42 CAL120 DMM 5 mM":"380499.8357","41 CAL120 Combination":"438923.0093","44 CAL120 Combination":"553741.8328","22 HCC1806 GSK 1 uM":"572817.9287","25 HCC1806 GSK 1 uM":"502545.4713","21 HCC1806 DMM 5 mM":"399784.5201","24 HCC1806 DMM 5 mM":"375847.8341","23 HCC1806 Combination":"423048.7723","26 HCC1806 Combination":"384876.1245","34 HS578T GSK 1 uM":"3808503.3110","37 HS578T GSK 1 uM":"3510592.0480","33 HS578T DMM 5 mM":"2202367.6540","36 HS578T DMM 5 mM":"2210867.6890","35 HS578T Combination":"2565063.7850","38 HS578T Combination":"2226682.5730","16 MCF7 GSK 1 uM":"111106.2111","19 MCF7 GSK 1 uM":"187260.3600","15 MCF7 DMM 5 mM":"109378.8426","18 MCF7 DMM 5 mM":"187296.6759","17 MCF7 Combination":"134593.9464","20 MCF7 Combination":"170210.7362","28 MDA-MB-231 GSK 1 uM":"2509609.5270","31 MDA-MB-231 GSK 1 uM":"3024177.1070","27 MDA-MB-231 DMM 5 mM":"1260336.1310","30 MDA-MB-231 DMM 5 mM":"1168154.6030","29 MDA-MB-231 Combination":"1321680.4570","32 MDA-MB-231 Combination":"1453226.1590","04 MDA-MB-468 GSK 1 uM":"6840247.0140","07 MDA-MB-468 GSK 1 uM":"7412247.2260","03 MDA-MB-468 DMM 5 mM":"4013839.3190","06 MDA-MB-468 DMM 5 mM":"4127646.5750","05 MDA-MB-468 Combination":"5255762.2590","08 MDA-MB-468 Combination":"5111640.0620","01 Blank":"1575.0811","46 Blank":"1775.5093","02 DMEM/F12 no adds":"337004.5297","45 DMEM/F12 no adds":"316970.6470","10 SUM159PT GSK 1 uM":"3910591.8540","13 SUM159PT GSK 1 uM":"5190628.9570","09 SUM159PT DMM 5 mM":"1222631.8590","12 SUM159PT DMM 5 mM":"1272669.0350","11 SUM159PT Combination":"1266255.0120","14 SUM159PT Combination":"1212798.0190"},{"Metabolite":"Stearic PAR","40 CAL120 GSK 1 uM":"273229.6063","43 CAL120 GSK 1 uM":"251603.0220","39 CAL120 DMM 5 mM":"325151.0102","42 CAL120 DMM 5 mM":"460969.7548","41 CAL120 Combination":"501863.7581","44 CAL120 Combination":"261116.6999","22 HCC1806 GSK 1 uM":"164457.4465","25 HCC1806 GSK 1 uM":"219144.0493","21 HCC1806 DMM 5 mM":"438243.5055","24 HCC1806 DMM 5 mM":"295681.2547","23 HCC1806 Combination":"294702.2684","26 HCC1806 Combination":"132972.1007","34 HS578T GSK 1 uM":"339051.2430","37 HS578T GSK 1 uM":"428102.8310","33 HS578T DMM 5 mM":"255602.3472","36 HS578T DMM 5 mM":"396367.3621","35 HS578T Combination":"529228.5625","38 HS578T Combination":"434550.3519","16 MCF7 GSK 1 uM":"135984.2633","19 MCF7 GSK 1 uM":"458300.1254","15 MCF7 DMM 5 mM":"91071.0566","18 MCF7 DMM 5 mM":"297900.2312","17 MCF7 Combination":"171818.7054","20 MCF7 Combination":"268950.7297","28 MDA-MB-231 GSK 1 uM":"150839.3201","31 MDA-MB-231 GSK 1 uM":"164517.5554","27 MDA-MB-231 DMM 5 mM":"230790.7106","30 MDA-MB-231 DMM 5 mM":"451966.5111","29 MDA-MB-231 Combination":"316269.9174","32 MDA-MB-231 Combination":"208553.1442","04 MDA-MB-468 GSK 1 uM":"443417.2563","07 MDA-MB-468 GSK 1 uM":"170027.4375","03 MDA-MB-468 DMM 5 mM":"300201.9946","06 MDA-MB-468 DMM 5 mM":"360493.5800","05 MDA-MB-468 Combination":"206525.9819","08 MDA-MB-468 Combination":"209549.5012","01 Blank":"10422.3195","46 Blank":"22327.2844","02 DMEM/F12 no adds":"36269.0561","45 DMEM/F12 no adds":"40381.9036","10 SUM159PT GSK 1 uM":"159566.8151","13 SUM159PT GSK 1 uM":"232979.7318","09 SUM159PT DMM 5 mM":"158316.8504","12 SUM159PT DMM 5 mM":"265689.9056","11 SUM159PT Combination":"274950.9715","14 SUM159PT Combination":"227872.1774"},{"Metabolite":"Succinic 73","40 CAL120 GSK 1 uM":"598523.4425","43 CAL120 GSK 1 uM":"18504.4725","39 CAL120 DMM 5 mM":"12865637.9400","42 CAL120 DMM 5 mM":"12751922.0500","41 CAL120 Combination":"18517325.9500","44 CAL120 Combination":"17937111.0600","22 HCC1806 GSK 1 uM":"3937401.6200","25 HCC1806 GSK 1 uM":"4350780.0830","21 HCC1806 DMM 5 mM":"23547658.0300","24 HCC1806 DMM 5 mM":"24162675.8600","23 HCC1806 Combination":"37745894.1400","26 HCC1806 Combination":"38361285.3600","34 HS578T GSK 1 uM":"203264.0796","37 HS578T GSK 1 uM":"4039.3490","33 HS578T DMM 5 mM":"908932.8800","36 HS578T DMM 5 mM":"947316.5504","35 HS578T Combination":"1316375.6250","38 HS578T Combination":"3917.3615","16 MCF7 GSK 1 uM":"3027455.5520","19 MCF7 GSK 1 uM":"2816402.3260","15 MCF7 DMM 5 mM":"33218678.9400","18 MCF7 DMM 5 mM":"29767295.3300","17 MCF7 Combination":"61465807.4500","20 MCF7 Combination":"38602979.7200","28 MDA-MB-231 GSK 1 uM":"833849.5956","31 MDA-MB-231 GSK 1 uM":"784643.5298","27 MDA-MB-231 DMM 5 mM":"13267869.8500","30 MDA-MB-231 DMM 5 mM":"12908065.6400","29 MDA-MB-231 Combination":"16728189.2700","32 MDA-MB-231 Combination":"18628467.2900","04 MDA-MB-468 GSK 1 uM":"1519218.2750","07 MDA-MB-468 GSK 1 uM":"1744423.8950","03 MDA-MB-468 DMM 5 mM":"41186905.6600","06 MDA-MB-468 DMM 5 mM":"41942521.0900","05 MDA-MB-468 Combination":"49957956.7100","08 MDA-MB-468 Combination":"49741606.7300","01 Blank":"15248.1651","46 Blank":"23276.3384","02 DMEM/F12 no adds":"10735.9309","45 DMEM/F12 no adds":"21231.5754","10 SUM159PT GSK 1 uM":"337002.8993","13 SUM159PT GSK 1 uM":"315182.7057","09 SUM159PT DMM 5 mM":"5356476.1940","12 SUM159PT DMM 5 mM":"5193031.3540","11 SUM159PT Combination":"5506690.0760","14 SUM159PT Combination":"6113572.8650"},{"Metabolite":"Succinic 99","40 CAL120 GSK 1 uM":"788.0114","43 CAL120 GSK 1 uM":"3396.0324","39 CAL120 DMM 5 mM":"1480815.9340","42 CAL120 DMM 5 mM":"1486444.5820","41 CAL120 Combination":"2146848.5040","44 CAL120 Combination":"2005631.5520","22 HCC1806 GSK 1 uM":"439920.0628","25 HCC1806 GSK 1 uM":"524370.3518","21 HCC1806 DMM 5 mM":"2761791.0400","24 HCC1806 DMM 5 mM":"2755805.1730","23 HCC1806 Combination":"4438883.8260","26 HCC1806 Combination":"4388026.2760","34 HS578T GSK 1 uM":"8992.2083","37 HS578T GSK 1 uM":"8566.6832","33 HS578T DMM 5 mM":"126434.1414","36 HS578T DMM 5 mM":"125139.4986","35 HS578T Combination":"148817.6670","38 HS578T Combination":"130805.8171","16 MCF7 GSK 1 uM":"338182.6912","19 MCF7 GSK 1 uM":"331016.2286","15 MCF7 DMM 5 mM":"3837721.6800","18 MCF7 DMM 5 mM":"3416497.4590","17 MCF7 Combination":"7316382.3950","20 MCF7 Combination":"4485796.0830","28 MDA-MB-231 GSK 1 uM":"96311.5361","31 MDA-MB-231 GSK 1 uM":"103361.9218","27 MDA-MB-231 DMM 5 mM":"1546482.2830","30 MDA-MB-231 DMM 5 mM":"1472023.1810","29 MDA-MB-231 Combination":"1938715.0360","32 MDA-MB-231 Combination":"2150419.0520","04 MDA-MB-468 GSK 1 uM":"184530.0463","07 MDA-MB-468 GSK 1 uM":"202597.0917","03 MDA-MB-468 DMM 5 mM":"4804082.5280","06 MDA-MB-468 DMM 5 mM":"4854394.8170","05 MDA-MB-468 Combination":"5908229.2410","08 MDA-MB-468 Combination":"5886734.4040","01 Blank":"1769.6606","46 Blank":"10320.8334","02 DMEM/F12 no adds":"6937.8811","45 DMEM/F12 no adds":"2292.3473","10 SUM159PT GSK 1 uM":"56769.0228","13 SUM159PT GSK 1 uM":"7134.3230","09 SUM159PT DMM 5 mM":"652256.6712","12 SUM159PT DMM 5 mM":"603129.7093","11 SUM159PT Combination":"670989.1938","14 SUM159PT Combination":"756895.4614"},{"Metabolite":"Succinyl-CoA 408","40 CAL120 GSK 1 uM":"4952.2909","43 CAL120 GSK 1 uM":"3789.2640","39 CAL120 DMM 5 mM":"4178.9177","42 CAL120 DMM 5 mM":"3347.1127","41 CAL120 Combination":"2864.3344","44 CAL120 Combination":"4473.5288","22 HCC1806 GSK 1 uM":"4757.3129","25 HCC1806 GSK 1 uM":"3932.2173","21 HCC1806 DMM 5 mM":"1579.5154","24 HCC1806 DMM 5 mM":"3648.2010","23 HCC1806 Combination":"5247.1436","26 HCC1806 Combination":"6226.3717","34 HS578T GSK 1 uM":"382.3640","37 HS578T GSK 1 uM":"326.0274","33 HS578T DMM 5 mM":"1475.8935","36 HS578T DMM 5 mM":"482.0149","35 HS578T Combination":"836.2073","38 HS578T Combination":"410.5138","16 MCF7 GSK 1 uM":"13528.5500","19 MCF7 GSK 1 uM":"12717.1082","15 MCF7 DMM 5 mM":"9863.6252","18 MCF7 DMM 5 mM":"9464.8578","17 MCF7 Combination":"22545.3051","20 MCF7 Combination":"12951.4454","28 MDA-MB-231 GSK 1 uM":"2558.8377","31 MDA-MB-231 GSK 1 uM":"2658.7229","27 MDA-MB-231 DMM 5 mM":"3149.1845","30 MDA-MB-231 DMM 5 mM":"4224.0619","29 MDA-MB-231 Combination":"1915.0829","32 MDA-MB-231 Combination":"2489.5588","04 MDA-MB-468 GSK 1 uM":"63886.9432","07 MDA-MB-468 GSK 1 uM":"62606.7417","03 MDA-MB-468 DMM 5 mM":"44109.8575","06 MDA-MB-468 DMM 5 mM":"44462.0605","05 MDA-MB-468 Combination":"59664.9332","08 MDA-MB-468 Combination":"61221.5552","01 Blank":"129.9938","46 Blank":"143.5638","02 DMEM/F12 no adds":"138.4049","45 DMEM/F12 no adds":"293.4688","10 SUM159PT GSK 1 uM":"4717.6958","13 SUM159PT GSK 1 uM":"3109.4928","09 SUM159PT DMM 5 mM":"634.4339","12 SUM159PT DMM 5 mM":"1193.1607","11 SUM159PT Combination":"3408.1885","14 SUM159PT Combination":"2712.2312"},{"Metabolite":"Taurine 80","40 CAL120 GSK 1 uM":"47343659.0500","43 CAL120 GSK 1 uM":"48336812.6300","39 CAL120 DMM 5 mM":"55050642.2700","42 CAL120 DMM 5 mM":"50386365.9500","41 CAL120 Combination":"50866426.8200","44 CAL120 Combination":"52202061.4700","22 HCC1806 GSK 1 uM":"54627177.8500","25 HCC1806 GSK 1 uM":"54030891.4300","21 HCC1806 DMM 5 mM":"44588015.1800","24 HCC1806 DMM 5 mM":"46157779.4800","23 HCC1806 Combination":"45201304.6900","26 HCC1806 Combination":"43537927.3600","34 HS578T GSK 1 uM":"16927066.4300","37 HS578T GSK 1 uM":"15873624.7300","33 HS578T DMM 5 mM":"14852584.6900","36 HS578T DMM 5 mM":"16627846.6000","35 HS578T Combination":"16699611.1300","38 HS578T Combination":"16338047.7300","16 MCF7 GSK 1 uM":"95066238.5400","19 MCF7 GSK 1 uM":"113497964.9000","15 MCF7 DMM 5 mM":"105450055.6000","18 MCF7 DMM 5 mM":"101906689.6000","17 MCF7 Combination":"112609566.2000","20 MCF7 Combination":"78634321.3700","28 MDA-MB-231 GSK 1 uM":"84429471.6500","31 MDA-MB-231 GSK 1 uM":"97829801.0000","27 MDA-MB-231 DMM 5 mM":"102326418.0000","30 MDA-MB-231 DMM 5 mM":"99903061.7900","29 MDA-MB-231 Combination":"89981183.9700","32 MDA-MB-231 Combination":"104718229.9000","04 MDA-MB-468 GSK 1 uM":"83038871.0500","07 MDA-MB-468 GSK 1 uM":"86877322.9900","03 MDA-MB-468 DMM 5 mM":"96741101.5400","06 MDA-MB-468 DMM 5 mM":"93485770.6100","05 MDA-MB-468 Combination":"96437257.7700","08 MDA-MB-468 Combination":"93384735.3700","01 Blank":"2018.7733","46 Blank":"3451.1019","02 DMEM/F12 no adds":"238013.5226","45 DMEM/F12 no adds":"59315.8331","10 SUM159PT GSK 1 uM":"116219586.5000","13 SUM159PT GSK 1 uM":"135249600.3000","09 SUM159PT DMM 5 mM":"129620420.4000","12 SUM159PT DMM 5 mM":"134187499.4000","11 SUM159PT Combination":"129867783.7000","14 SUM159PT Combination":"142844573.8000"},{"Metabolite":"Trehalose 59","40 CAL120 GSK 1 uM":"19485.2965","43 CAL120 GSK 1 uM":"12640.7272","39 CAL120 DMM 5 mM":"16783.3590","42 CAL120 DMM 5 mM":"12387.7720","41 CAL120 Combination":"221211.6648","44 CAL120 Combination":"14978.8418","22 HCC1806 GSK 1 uM":"16975.6927","25 HCC1806 GSK 1 uM":"28829.3491","21 HCC1806 DMM 5 mM":"32210.3774","24 HCC1806 DMM 5 mM":"27041.2713","23 HCC1806 Combination":"36028.0504","26 HCC1806 Combination":"34196.1173","34 HS578T GSK 1 uM":"15316.4742","37 HS578T GSK 1 uM":"10321.5131","33 HS578T DMM 5 mM":"34232.6548","36 HS578T DMM 5 mM":"8689.2905","35 HS578T Combination":"17316.5067","38 HS578T Combination":"24062.6056","16 MCF7 GSK 1 uM":"16075.7594","19 MCF7 GSK 1 uM":"8053.7777","15 MCF7 DMM 5 mM":"14990.1228","18 MCF7 DMM 5 mM":"12038.8079","17 MCF7 Combination":"4198.6427","20 MCF7 Combination":"7026.3951","28 MDA-MB-231 GSK 1 uM":"26339.5145","31 MDA-MB-231 GSK 1 uM":"15094.9512","27 MDA-MB-231 DMM 5 mM":"33509.8207","30 MDA-MB-231 DMM 5 mM":"39831.5011","29 MDA-MB-231 Combination":"25646.6545","32 MDA-MB-231 Combination":"13719.6230","04 MDA-MB-468 GSK 1 uM":"22081.3049","07 MDA-MB-468 GSK 1 uM":"14423.9544","03 MDA-MB-468 DMM 5 mM":"38807.9975","06 MDA-MB-468 DMM 5 mM":"27851.6330","05 MDA-MB-468 Combination":"43539.5013","08 MDA-MB-468 Combination":"24601.5053","01 Blank":"2051.2561","46 Blank":"2196.5570","02 DMEM/F12 no adds":"76804.6356","45 DMEM/F12 no adds":"59836.8727","10 SUM159PT GSK 1 uM":"9657.1554","13 SUM159PT GSK 1 uM":"19100.1894","09 SUM159PT DMM 5 mM":"27515.3932","12 SUM159PT DMM 5 mM":"13275.6191","11 SUM159PT Combination":"15304.2356","14 SUM159PT Combination":"10737.5357"},{"Metabolite":"Uric 124","40 CAL120 GSK 1 uM":"127189.3359","43 CAL120 GSK 1 uM":"143803.3238","39 CAL120 DMM 5 mM":"100678.7996","42 CAL120 DMM 5 mM":"112585.0948","41 CAL120 Combination":"108740.1887","44 CAL120 Combination":"132476.0784","22 HCC1806 GSK 1 uM":"1036363.8200","25 HCC1806 GSK 1 uM":"1082548.5680","21 HCC1806 DMM 5 mM":"1230040.5030","24 HCC1806 DMM 5 mM":"1523581.6200","23 HCC1806 Combination":"1997549.8530","26 HCC1806 Combination":"1631686.4870","34 HS578T GSK 1 uM":"54540.3788","37 HS578T GSK 1 uM":"41293.5583","33 HS578T DMM 5 mM":"24214.2492","36 HS578T DMM 5 mM":"33438.0804","35 HS578T Combination":"40505.5507","38 HS578T Combination":"57176.8486","16 MCF7 GSK 1 uM":"59587.0600","19 MCF7 GSK 1 uM":"96943.9149","15 MCF7 DMM 5 mM":"61135.6209","18 MCF7 DMM 5 mM":"150655.9649","17 MCF7 Combination":"113670.2882","20 MCF7 Combination":"50733.8090","28 MDA-MB-231 GSK 1 uM":"143182.8394","31 MDA-MB-231 GSK 1 uM":"140438.8969","27 MDA-MB-231 DMM 5 mM":"124327.8962","30 MDA-MB-231 DMM 5 mM":"118700.7495","29 MDA-MB-231 Combination":"92532.9631","32 MDA-MB-231 Combination":"116073.5431","04 MDA-MB-468 GSK 1 uM":"295147.6762","07 MDA-MB-468 GSK 1 uM":"383694.6639","03 MDA-MB-468 DMM 5 mM":"266603.4679","06 MDA-MB-468 DMM 5 mM":"267499.6056","05 MDA-MB-468 Combination":"288470.8681","08 MDA-MB-468 Combination":"446450.6082","01 Blank":"528.8967","46 Blank":"2290.1032","02 DMEM/F12 no adds":"7536.7821","45 DMEM/F12 no adds":"14182.3242","10 SUM159PT GSK 1 uM":"162456.5957","13 SUM159PT GSK 1 uM":"171731.2722","09 SUM159PT DMM 5 mM":"164753.0158","12 SUM159PT DMM 5 mM":"109171.2291","11 SUM159PT Combination":"132624.2024","14 SUM159PT Combination":"142025.8633"},{"Metabolite":"Uric 96","40 CAL120 GSK 1 uM":"51185.0782","43 CAL120 GSK 1 uM":"55808.0281","39 CAL120 DMM 5 mM":"32368.2273","42 CAL120 DMM 5 mM":"44161.9957","41 CAL120 Combination":"41396.0895","44 CAL120 Combination":"50890.6617","22 HCC1806 GSK 1 uM":"446773.9565","25 HCC1806 GSK 1 uM":"421082.0426","21 HCC1806 DMM 5 mM":"505871.8022","24 HCC1806 DMM 5 mM":"611352.2944","23 HCC1806 Combination":"744513.1428","26 HCC1806 Combination":"699782.9078","34 HS578T GSK 1 uM":"17777.5477","37 HS578T GSK 1 uM":"13348.3175","33 HS578T DMM 5 mM":"7564.6300","36 HS578T DMM 5 mM":"10344.2695","35 HS578T Combination":"12769.1500","38 HS578T Combination":"19879.8637","16 MCF7 GSK 1 uM":"19671.6782","19 MCF7 GSK 1 uM":"34294.2943","15 MCF7 DMM 5 mM":"17419.4169","18 MCF7 DMM 5 mM":"56067.4264","17 MCF7 Combination":"38134.5140","20 MCF7 Combination":"23020.0718","28 MDA-MB-231 GSK 1 uM":"51718.1004","31 MDA-MB-231 GSK 1 uM":"56474.1097","27 MDA-MB-231 DMM 5 mM":"45434.1124","30 MDA-MB-231 DMM 5 mM":"37848.6306","29 MDA-MB-231 Combination":"34109.5609","32 MDA-MB-231 Combination":"50085.8007","04 MDA-MB-468 GSK 1 uM":"108995.5911","07 MDA-MB-468 GSK 1 uM":"140683.4098","03 MDA-MB-468 DMM 5 mM":"112009.1865","06 MDA-MB-468 DMM 5 mM":"104363.8691","05 MDA-MB-468 Combination":"104208.8516","08 MDA-MB-468 Combination":"173704.6762","01 Blank":"","46 Blank":"1574.0251","02 DMEM/F12 no adds":"92.8325","45 DMEM/F12 no adds":"1319.4695","10 SUM159PT GSK 1 uM":"59363.6119","13 SUM159PT GSK 1 uM":"66920.8766","09 SUM159PT DMM 5 mM":"54346.2185","12 SUM159PT DMM 5 mM":"41452.5117","11 SUM159PT Combination":"55069.9648","14 SUM159PT Combination":"54972.4455"},{"Metabolite":"Uridine 111","40 CAL120 GSK 1 uM":"462560.0554","43 CAL120 GSK 1 uM":"407292.3243","39 CAL120 DMM 5 mM":"340932.7694","42 CAL120 DMM 5 mM":"312729.7829","41 CAL120 Combination":"328750.0749","44 CAL120 Combination":"327242.0210","22 HCC1806 GSK 1 uM":"118840.3483","25 HCC1806 GSK 1 uM":"116614.6221","21 HCC1806 DMM 5 mM":"276441.2102","24 HCC1806 DMM 5 mM":"132628.7129","23 HCC1806 Combination":"194893.9522","26 HCC1806 Combination":"229641.8854","34 HS578T GSK 1 uM":"45461.1509","37 HS578T GSK 1 uM":"53212.3197","33 HS578T DMM 5 mM":"58912.6831","36 HS578T DMM 5 mM":"58437.0933","35 HS578T Combination":"62127.8787","38 HS578T Combination":"95772.6392","16 MCF7 GSK 1 uM":"35446.1014","19 MCF7 GSK 1 uM":"41669.5358","15 MCF7 DMM 5 mM":"61093.8229","18 MCF7 DMM 5 mM":"96106.1918","17 MCF7 Combination":"53610.2313","20 MCF7 Combination":"34415.0504","28 MDA-MB-231 GSK 1 uM":"325638.2262","31 MDA-MB-231 GSK 1 uM":"248307.2366","27 MDA-MB-231 DMM 5 mM":"166817.8092","30 MDA-MB-231 DMM 5 mM":"194575.3906","29 MDA-MB-231 Combination":"309662.8578","32 MDA-MB-231 Combination":"252328.3681","04 MDA-MB-468 GSK 1 uM":"98477.6192","07 MDA-MB-468 GSK 1 uM":"93905.4400","03 MDA-MB-468 DMM 5 mM":"141087.5072","06 MDA-MB-468 DMM 5 mM":"126227.8945","05 MDA-MB-468 Combination":"91093.3519","08 MDA-MB-468 Combination":"127508.0241","01 Blank":"578.1714","46 Blank":"2187.8278","02 DMEM/F12 no adds":"552.1144","45 DMEM/F12 no adds":"326.8944","10 SUM159PT GSK 1 uM":"73552.8373","13 SUM159PT GSK 1 uM":"70085.6526","09 SUM159PT DMM 5 mM":"67139.4548","12 SUM159PT DMM 5 mM":"81220.6638","11 SUM159PT Combination":"97278.7524","14 SUM159PT Combination":"102908.8606"},{"Metabolite":"Xanthine 108","40 CAL120 GSK 1 uM":"3271753.6320","43 CAL120 GSK 1 uM":"3430871.5350","39 CAL120 DMM 5 mM":"3589809.4970","42 CAL120 DMM 5 mM":"3336131.5500","41 CAL120 Combination":"3513273.2570","44 CAL120 Combination":"3524068.5700","22 HCC1806 GSK 1 uM":"1619990.0580","25 HCC1806 GSK 1 uM":"1533077.9210","21 HCC1806 DMM 5 mM":"1719839.5930","24 HCC1806 DMM 5 mM":"1548256.5640","23 HCC1806 Combination":"1678616.8410","26 HCC1806 Combination":"1699429.4910","34 HS578T GSK 1 uM":"3900045.9600","37 HS578T GSK 1 uM":"4114797.7470","33 HS578T DMM 5 mM":"3838539.4320","36 HS578T DMM 5 mM":"3660933.3990","35 HS578T Combination":"4001580.8090","38 HS578T Combination":"177424.1457","16 MCF7 GSK 1 uM":"521943.5177","19 MCF7 GSK 1 uM":"600628.9046","15 MCF7 DMM 5 mM":"527707.3638","18 MCF7 DMM 5 mM":"715137.9763","17 MCF7 Combination":"536116.9171","20 MCF7 Combination":"542740.7268","28 MDA-MB-231 GSK 1 uM":"879065.6150","31 MDA-MB-231 GSK 1 uM":"785838.8954","27 MDA-MB-231 DMM 5 mM":"721499.5472","30 MDA-MB-231 DMM 5 mM":"744005.3616","29 MDA-MB-231 Combination":"816922.3900","32 MDA-MB-231 Combination":"783302.5574","04 MDA-MB-468 GSK 1 uM":"918284.9469","07 MDA-MB-468 GSK 1 uM":"986840.9489","03 MDA-MB-468 DMM 5 mM":"1710378.4700","06 MDA-MB-468 DMM 5 mM":"1336613.3670","05 MDA-MB-468 Combination":"1020534.0390","08 MDA-MB-468 Combination":"1516891.1730","01 Blank":"1838.3249","46 Blank":"2099.4051","02 DMEM/F12 no adds":"6610.9637","45 DMEM/F12 no adds":"4811.7865","10 SUM159PT GSK 1 uM":"861014.9058","13 SUM159PT GSK 1 uM":"1072430.5750","09 SUM159PT DMM 5 mM":"798654.0367","12 SUM159PT DMM 5 mM":"868679.8193","11 SUM159PT Combination":"949846.7176","14 SUM159PT Combination":"928687.8012"},{"Metabolite":"Xanthosine 151","40 CAL120 GSK 1 uM":"2072459.4870","43 CAL120 GSK 1 uM":"1980435.7450","39 CAL120 DMM 5 mM":"2128278.6460","42 CAL120 DMM 5 mM":"1965752.8810","41 CAL120 Combination":"2056381.8100","44 CAL120 Combination":"1977635.6480","22 HCC1806 GSK 1 uM":"1610733.1080","25 HCC1806 GSK 1 uM":"1565001.8280","21 HCC1806 DMM 5 mM":"1665145.6450","24 HCC1806 DMM 5 mM":"1705662.1930","23 HCC1806 Combination":"1755503.9320","26 HCC1806 Combination":"1632702.6910","34 HS578T GSK 1 uM":"2746259.7700","37 HS578T GSK 1 uM":"2473204.7980","33 HS578T DMM 5 mM":"1912682.8460","36 HS578T DMM 5 mM":"2454488.0640","35 HS578T Combination":"2451442.2890","38 HS578T Combination":"47379.2964","16 MCF7 GSK 1 uM":"157292.5782","19 MCF7 GSK 1 uM":"182455.4425","15 MCF7 DMM 5 mM":"140163.5152","18 MCF7 DMM 5 mM":"144810.3593","17 MCF7 Combination":"117542.1385","20 MCF7 Combination":"100873.8916","28 MDA-MB-231 GSK 1 uM":"954862.1920","31 MDA-MB-231 GSK 1 uM":"943403.5539","27 MDA-MB-231 DMM 5 mM":"838348.7129","30 MDA-MB-231 DMM 5 mM":"862080.0114","29 MDA-MB-231 Combination":"871264.7652","32 MDA-MB-231 Combination":"992246.6838","04 MDA-MB-468 GSK 1 uM":"190053.2863","07 MDA-MB-468 GSK 1 uM":"186346.5652","03 MDA-MB-468 DMM 5 mM":"229897.0112","06 MDA-MB-468 DMM 5 mM":"192251.5255","05 MDA-MB-468 Combination":"202284.1617","08 MDA-MB-468 Combination":"233731.6768","01 Blank":"861.6632","46 Blank":"1082.0778","02 DMEM/F12 no adds":"1506.1662","45 DMEM/F12 no adds":"1304.2743","10 SUM159PT GSK 1 uM":"1172347.0610","13 SUM159PT GSK 1 uM":"1086546.2250","09 SUM159PT DMM 5 mM":"1037235.8280","12 SUM159PT DMM 5 mM":"1129630.7740","11 SUM159PT Combination":"1217159.3000","14 SUM159PT Combination":"1211045.1190"}],
"Metabolites":[{"Metabolite":"2-Hydroxybutyric 17","pubchem_id":"11266","inchi_key":"","kegg_id":"C05984","other_id":"","other_id_type":"","ri":"2.42","ri_type":"","moverz_quant":"","":""},{"Metabolite":"2-Hydroxybutyric 57","pubchem_id":"","inchi_key":"","kegg_id":"","other_id":"","other_id_type":"","ri":"2.48","ri_type":"","moverz_quant":"","":""},{"Metabolite":"3-Hydroxybutyric 17","pubchem_id":"441","inchi_key":"","kegg_id":"C01089","other_id":"","other_id_type":"","ri":"2.95","ri_type":"","moverz_quant":"","":""},{"Metabolite":"3-Hydroxybutyric 59","pubchem_id":"441","inchi_key":"","kegg_id":"C01089","other_id":"","other_id_type":"","ri":"2.92","ri_type":"","moverz_quant":"","":""},{"Metabolite":"aCD 101","pubchem_id":"444913","inchi_key":"","kegg_id":"D08846","other_id":"","other_id_type":"","ri":"","ri_type":"","moverz_quant":"","":""},{"Metabolite":"aCD 161","pubchem_id":"444913","inchi_key":"","kegg_id":"D08846","other_id":"","other_id_type":"","ri":"7.27","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Acetic PAR","pubchem_id":"176","inchi_key":"","kegg_id":"C00033","other_id":"","other_id_type":"","ri":"3.35","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Acetyl-CoA 408","pubchem_id":"444493","inchi_key":"","kegg_id":"C00024","other_id":"","other_id_type":"","ri":"5.57","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Acetyl-CoA 461","pubchem_id":"444493","inchi_key":"","kegg_id":"C00024","other_id":"","other_id_type":"","ri":"5.57","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Acetyl-CoA 79","pubchem_id":"444493","inchi_key":"","kegg_id":"C00024","other_id":"","other_id_type":"","ri":"5.57","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Alanine NEG PAR","pubchem_id":"5950","inchi_key":"","kegg_id":"C00041","other_id":"","other_id_type":"","ri":"6.32","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Arginine 131","pubchem_id":"6322","inchi_key":"","kegg_id":"C00062","other_id":"","other_id_type":"","ri":"12.96","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Arginine 156","pubchem_id":"6322","inchi_key":"","kegg_id":"C00062","other_id":"","other_id_type":"","ri":"12.96","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Ascorbic 157","pubchem_id":"54670067","inchi_key":"","kegg_id":"C00072","other_id":"","other_id_type":"","ri":"6.58","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Ascorbic 79","pubchem_id":"54670067","inchi_key":"","kegg_id":"C00072","other_id":"","other_id_type":"","ri":"7.34","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Asparagine 113","pubchem_id":"6267","inchi_key":"","kegg_id":"C00152","other_id":"","other_id_type":"","ri":"6.72","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Aspartic 115","pubchem_id":"5960","inchi_key":"","kegg_id":"C0004","other_id":"","other_id_type":"","ri":"6.65","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Aspartic 88","pubchem_id":"5960","inchi_key":"","kegg_id":"C0004","other_id":"","other_id_type":"","ri":"6.64","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Butyric PAR","pubchem_id":"264","inchi_key":"","kegg_id":"C00246","other_id":"","other_id_type":"","ri":"2.57","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Butyryl-CoA 408","pubchem_id":"122283","inchi_key":"","kegg_id":"C00136","other_id":"","other_id_type":"","ri":"4.63","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Butyryl-CoA 79","pubchem_id":"122283","inchi_key":"","kegg_id":"C00136","other_id":"","other_id_type":"","ri":"4.67","ri_type":"","moverz_quant":"","":""},{"Metabolite":"C75 209","pubchem_id":"4248455","inchi_key":"","kegg_id":"","other_id":"","other_id_type":"","ri":"1.46","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Cholic 343","pubchem_id":"221493","inchi_key":"","kegg_id":"C00695","other_id":"","other_id_type":"","ri":"1.59","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Citraconic 85","pubchem_id":"643798","inchi_key":"","kegg_id":"C02226","other_id":"","other_id_type":"","ri":"2.66","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Citric 111","pubchem_id":"311","inchi_key":"","kegg_id":"C00158","other_id":"","other_id_type":"","ri":"8.86","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Citric 173","pubchem_id":"311","inchi_key":"","kegg_id":"C00158","other_id":"","other_id_type":"","ri":"8.99","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Citrulline 131","pubchem_id":"9750","inchi_key":"","kegg_id":"C00327","other_id":"","other_id_type":"","ri":"7.06","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Coenzyme A 408","pubchem_id":"87642","inchi_key":"","kegg_id":"C00010","other_id":"","other_id_type":"","ri":"6.35","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Coenzyme A 79","pubchem_id":"87642","inchi_key":"","kegg_id":"C00010","other_id":"","other_id_type":"","ri":"6.35","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Cysteine PAR","pubchem_id":"5862","inchi_key":"","kegg_id":"C00097","other_id":"","other_id_type":"","ri":"6.23","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Cystine 120","pubchem_id":"67678","inchi_key":"","kegg_id":"C00491","other_id":"","other_id_type":"","ri":"7.23","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Cystine 74","pubchem_id":"67678","inchi_key":"","kegg_id":"C00491","other_id":"","other_id_type":"","ri":"7.23","ri_type":"","moverz_quant":"","":""},{"Metabolite":"FAD 408","pubchem_id":"643975","inchi_key":"","kegg_id":"C00016","other_id":"","other_id_type":"","ri":"4.77","ri_type":"","moverz_quant":"","":""},{"Metabolite":"FAD 79","pubchem_id":"643975","inchi_key":"","kegg_id":"C00016","other_id":"","other_id_type":"","ri":"4.76","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Folic 311","pubchem_id":"135398658","inchi_key":"","kegg_id":"C00504","other_id":"","other_id_type":"","ri":"7.79","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Formic PAR","pubchem_id":"284","inchi_key":"","kegg_id":"C00058","other_id":"","other_id_type":"","ri":"3.72","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Formyl-CoA 408","pubchem_id":"3082032","inchi_key":"","kegg_id":"C00798","other_id":"","other_id_type":"","ri":"6.22","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Formyl-CoA 79","pubchem_id":"3082032","inchi_key":"","kegg_id":"C00798","other_id":"","other_id_type":"","ri":"6.21","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Fructose-1,6-bisphosphate 177","pubchem_id":"10267","inchi_key":"","kegg_id":"C05378","other_id":"","other_id_type":"","ri":"6.96","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Fructose-1,6-bisphosphate 97","pubchem_id":"10267","inchi_key":"","kegg_id":"C05378","other_id":"","other_id_type":"","ri":"6.95","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Fumaric 71","pubchem_id":"444972","inchi_key":"","kegg_id":"C00122","other_id":"","other_id_type":"","ri":"7.48","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Glucose 59","pubchem_id":"5793","inchi_key":"","kegg_id":"C00031","other_id":"","other_id_type":"","ri":"6.27","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Glucose 6-phosphate 139","pubchem_id":"5958","inchi_key":"","kegg_id":"C00092","other_id":"","other_id_type":"","ri":"7.94","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Glucose 6-phosphate 97","pubchem_id":"5958","inchi_key":"","kegg_id":"C00092","other_id":"","other_id_type":"","ri":"7.94","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Glucose 71","pubchem_id":"5793","inchi_key":"","kegg_id":"C00031","other_id":"","other_id_type":"","ri":"6.26","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Glutamic acid 102","pubchem_id":"33032","inchi_key":"","kegg_id":"C00025","other_id":"","other_id_type":"","ri":"6.36","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Glutamic acid 128","pubchem_id":"33032","inchi_key":"","kegg_id":"C00025","other_id":"","other_id_type":"","ri":"6.37","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Glycerol 2-phosphate 127","pubchem_id":"2526","inchi_key":"","kegg_id":"C02979","other_id":"","other_id_type":"","ri":"6.53","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Glycerol 2-phosphate 79","pubchem_id":"2526","inchi_key":"","kegg_id":"C02979","other_id":"","other_id_type":"","ri":"6.75","ri_type":"","moverz_quant":"","":""},{"Metabolite":"GSSG 179","pubchem_id":"65359","inchi_key":"","kegg_id":"C00127","other_id":"","other_id_type":"","ri":"8.17","ri_type":"","moverz_quant":"","":""},{"Metabolite":"GSSG 306","pubchem_id":"65359","inchi_key":"","kegg_id":"C00127","other_id":"","other_id_type":"","ri":"8.17","ri_type":"","moverz_quant":"","":""},{"Metabolite":"HEPES 107","pubchem_id":"23831","inchi_key":"","kegg_id":"","other_id":"","other_id_type":"","ri":"3.81","ri_type":"","moverz_quant":"","":""},{"Metabolite":"HEPES 80","pubchem_id":"23831","inchi_key":"","kegg_id":"","other_id":"","other_id_type":"","ri":"3.76","ri_type":"","moverz_quant":"","":""},{"Metabolite":"HMG-CoA 408","pubchem_id":"445127","inchi_key":"","kegg_id":"C00356","other_id":"","other_id_type":"","ri":"7.22","ri_type":"","moverz_quant":"","":""},{"Metabolite":"HMG-CoA 426","pubchem_id":"445127","inchi_key":"","kegg_id":"C00356","other_id":"","other_id_type":"","ri":"7.23","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Ketoglutaric 101","pubchem_id":"51","inchi_key":"","kegg_id":"C00026","other_id":"","other_id_type":"","ri":"7.15","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Ketoglutaric 57","pubchem_id":"51","inchi_key":"","kegg_id":"C00026","other_id":"","other_id_type":"","ri":"7.15","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Lactic 71","pubchem_id":"612","inchi_key":"","kegg_id":"C01432","other_id":"","other_id_type":"","ri":"3.05","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Lactic 87","pubchem_id":"612","inchi_key":"","kegg_id":"C01432","other_id":"","other_id_type":"","ri":"3.05","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Lauroyl-CoA 408","pubchem_id":"165436","inchi_key":"","kegg_id":"C01832","other_id":"","other_id_type":"","ri":"2.82","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Maleic 27","pubchem_id":"444266","inchi_key":"","kegg_id":"C01384","other_id":"","other_id_type":"","ri":"3.23","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Maleic 71","pubchem_id":"444266","inchi_key":"","kegg_id":"C01384","other_id":"","other_id_type":"","ri":"3.24","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Malic 115","pubchem_id":"222656","inchi_key":"","kegg_id":"C00149","other_id":"","other_id_type":"","ri":"7.47","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Malic 71","pubchem_id":"222656","inchi_key":"","kegg_id":"C00149","other_id":"","other_id_type":"","ri":"7.47","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Malonic 59","pubchem_id":"867","inchi_key":"","kegg_id":"C00383","other_id":"","other_id_type":"","ri":"6.89","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Malonyl-CoA 408","pubchem_id":"644066","inchi_key":"","kegg_id":"C00083","other_id":"","other_id_type":"","ri":"7.96","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Malonyl-CoA 426","pubchem_id":"644066","inchi_key":"","kegg_id":"C00083","other_id":"","other_id_type":"","ri":"7.96","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Mannitol 89","pubchem_id":"6251","inchi_key":"","kegg_id":"C00392","other_id":"","other_id_type":"","ri":"5.8","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Mannose 59","pubchem_id":"18950","inchi_key":"","kegg_id":"C00159","other_id":"","other_id_type":"","ri":"6.24","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Mannose 95","pubchem_id":"18950","inchi_key":"","kegg_id":"C00159","other_id":"","other_id_type":"","ri":"5.79","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Methylcrotonyl-CoA 408","pubchem_id":"6443760","inchi_key":"","kegg_id":"C03345","other_id":"","other_id_type":"","ri":"6.11","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Methylcrotonyl-CoA 79","pubchem_id":"6443760","inchi_key":"","kegg_id":"C03345","other_id":"","other_id_type":"","ri":"6.12","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Methylmalonic 55","pubchem_id":"487","inchi_key":"","kegg_id":"C02170","other_id":"","other_id_type":"","ri":"6.13","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Methylmalonic 73","pubchem_id":"487","inchi_key":"","kegg_id":"C02170","other_id":"","other_id_type":"","ri":"6.13","ri_type":"","moverz_quant":"","":""},{"Metabolite":"myo-Inositol 161","pubchem_id":"892","inchi_key":"","kegg_id":"C00137","other_id":"","other_id_type":"","ri":"7.6","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Myristic PAR","pubchem_id":"11005","inchi_key":"","kegg_id":"C06424","other_id":"","other_id_type":"","ri":"1.39","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Myristoyl-CoA 408","pubchem_id":"11966124","inchi_key":"","kegg_id":"C02593","other_id":"","other_id_type":"","ri":"2.81","ri_type":"","moverz_quant":"","":""},{"Metabolite":"NAD+ 273","pubchem_id":"5892","inchi_key":"","kegg_id":"C00006","other_id":"","other_id_type":"","ri":"6.1","ri_type":"","moverz_quant":"","":""},{"Metabolite":"NAD+ 540","pubchem_id":"5892","inchi_key":"","kegg_id":"C00006","other_id":"","other_id_type":"","ri":"6.1","ri_type":"","moverz_quant":"","":""},{"Metabolite":"NADH 335","pubchem_id":"439153","inchi_key":"","kegg_id":"C00004","other_id":"","other_id_type":"","ri":"5.95","ri_type":"","moverz_quant":"","":""},{"Metabolite":"NADH 408","pubchem_id":"439153","inchi_key":"","kegg_id":"C00004","other_id":"","other_id_type":"","ri":"5.95","ri_type":"","moverz_quant":"","":""},{"Metabolite":"NADPH 328","pubchem_id":"5884","inchi_key":"","kegg_id":"C00005","other_id":"","other_id_type":"","ri":"8.38","ri_type":"","moverz_quant":"","":""},{"Metabolite":"NADPH 408","pubchem_id":"5884","inchi_key":"","kegg_id":"C00005","other_id":"","other_id_type":"","ri":"8.38","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Octanoyl-CoA 79","pubchem_id":"445344","inchi_key":"","kegg_id":"C01944","other_id":"","other_id_type":"","ri":"7.2","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Oleoyl-CoA (18:1) 79","pubchem_id":"5497111","inchi_key":"","kegg_id":"C00510","other_id":"","other_id_type":"","ri":"2.81","ri_type":"","moverz_quant":"","":""},{"Metabolite":"O-Phospho-L-serine 79","pubchem_id":"68841","inchi_key":"","kegg_id":"C01005","other_id":"","other_id_type":"","ri":"7.78","ri_type":"","moverz_quant":"","":""},{"Metabolite":"O-Phospho-L-serine 97","pubchem_id":"68841","inchi_key":"","kegg_id":"C01005","other_id":"","other_id_type":"","ri":"7.78","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Oxaloacetic 87","pubchem_id":"970","inchi_key":"","kegg_id":"C00036","other_id":"","other_id_type":"","ri":"7.98","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Palmitic PAR","pubchem_id":"985","inchi_key":"","kegg_id":"C00249","other_id":"","other_id_type":"","ri":"1.38","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Palmitoleic PAR","pubchem_id":"445638","inchi_key":"","kegg_id":"C08362","other_id":"","other_id_type":"","ri":"1.39","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Palmitoleyl-CoA (16:1) 79","pubchem_id":"25244394","inchi_key":"","kegg_id":"C21072","other_id":"","other_id_type":"","ri":"2.81","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Palmitoyl-CoA (16:0) 79","pubchem_id":"644109","inchi_key":"","kegg_id":"C00154","other_id":"","other_id_type":"","ri":"2.81","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Pemetrexed 297","pubchem_id":"135410875","inchi_key":"","kegg_id":"D07472","other_id":"","other_id_type":"","ri":"5.75","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Pemetrexed 321","pubchem_id":"135410875","inchi_key":"","kegg_id":"D07472","other_id":"","other_id_type":"","ri":"5.82","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Penicillin G 289","pubchem_id":"5904","inchi_key":"","kegg_id":"C05551","other_id":"","other_id_type":"","ri":"2.77","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Phenol Red 195","pubchem_id":"4766","inchi_key":"","kegg_id":"C12600","other_id":"","other_id_type":"","ri":"1.67","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Phenol Red 93","pubchem_id":"4766","inchi_key":"","kegg_id":"C12600","other_id":"","other_id_type":"","ri":"1.66","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Phenylalanine 147","pubchem_id":"6140","inchi_key":"","kegg_id":"C00079","other_id":"","other_id_type":"","ri":"3.84","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Phenylalanine 72","pubchem_id":"6140","inchi_key":"","kegg_id":"C00079","other_id":"","other_id_type":"","ri":"3.84","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Propionic PAR","pubchem_id":"1032","inchi_key":"","kegg_id":"C00163","other_id":"","other_id_type":"","ri":"3.04","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Propionyl-CoA 408","pubchem_id":"92753","inchi_key":"","kegg_id":"C00100","other_id":"","other_id_type":"","ri":"5.08","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Pyroglutamic 82","pubchem_id":"7405","inchi_key":"","kegg_id":"C01879","other_id":"","other_id_type":"","ri":"3.6","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Pyruvic 32","pubchem_id":"1060","inchi_key":"","kegg_id":"C00022","other_id":"","other_id_type":"","ri":"2.77","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Riboflavin 243","pubchem_id":"493570","inchi_key":"","kegg_id":"C00255","other_id":"","other_id_type":"","ri":"3.06","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Sorbitol 71","pubchem_id":"5780","inchi_key":"","kegg_id":"C00794","other_id":"","other_id_type":"","ri":"5.8","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Stearic PAR","pubchem_id":"5281","inchi_key":"","kegg_id":"C01530","other_id":"","other_id_type":"","ri":"1.38","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Succinic 73","pubchem_id":"1110","inchi_key":"","kegg_id":"C00042","other_id":"","other_id_type":"","ri":"6.87","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Succinic 99","pubchem_id":"1110","inchi_key":"","kegg_id":"C00042","other_id":"","other_id_type":"","ri":"6.87","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Succinyl-CoA 408","pubchem_id":"92133","inchi_key":"","kegg_id":"C00091","other_id":"","other_id_type":"","ri":"7.6","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Taurine 80","pubchem_id":"1123","inchi_key":"","kegg_id":"C00245","other_id":"","other_id_type":"","ri":"6.45","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Trehalose 59","pubchem_id":"7427","inchi_key":"","kegg_id":"C01083","other_id":"","other_id_type":"","ri":"7.1","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Uric 124","pubchem_id":"1175","inchi_key":"","kegg_id":"C00366","other_id":"","other_id_type":"","ri":"5.24","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Uric 96","pubchem_id":"1175","inchi_key":"","kegg_id":"C00366","other_id":"","other_id_type":"","ri":"5.24","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Uridine 111","pubchem_id":"6029","inchi_key":"","kegg_id":"C00299","other_id":"","other_id_type":"","ri":"3.73","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Xanthine 108","pubchem_id":"1188","inchi_key":"","kegg_id":"C00385","other_id":"","other_id_type":"","ri":"4.32","ri_type":"","moverz_quant":"","":""},{"Metabolite":"Xanthosine 151","pubchem_id":"64959","inchi_key":"","kegg_id":"C01762","other_id":"","other_id_type":"","ri":"5.01","ri_type":"","moverz_quant":"","":""}]
}
}