{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003431","ANALYSIS_ID":"AN005636","VERSION":"1","CREATED_ON":"08-26-2024"},

"PROJECT":{"PROJECT_TITLE":"The shutdown of NADH oxidation via Respiratory Complex I mimics fatty acid biosynthesis inhibition","PROJECT_TYPE":"LC-MS Quantitative Analysis","PROJECT_SUMMARY":"Proliferating cancer cells actively utilize anabolic processes for biomass production, including de novo biosynthesis of amino acids, nucleotides, and fatty acids. The key enzyme of the fatty acid biosynthesis pathway, fatty acid synthase (FASN), is widely recognized as a promising therapeutic target in cancer and other health conditions. Here, we establish a metabolic signature of FASN inhibition using a panel of pharmacological inhibitors (GSK2194069, TVB-2640, TVB-3166, C75, cerulenin, and Fasnall). We find that the activity of some commonly used FASN inhibitors is inconsistent with the metabolic signature of FASN inhibition (accumulation of malonate, succinate, malonyl coenzyme A, succinyl coenzyme A, and other metabolic perturbations). Moreover, we show that one of these putative FASN inhibitors, Fasnall, is a respiratory Complex I inhibitor that mimics FASN inhibition through NADH accumulation and consequent depletion of the tricarboxylic acid cycle metabolites. We demonstrate that Fasnall impairs tumor growth in several oxidative phosphorylation-dependent cancer models, including combination therapy-resistant melanoma patient-derived xenografts. Fasnall administration does not reproduce neurological side effects in mice reported for other Complex I inhibitors. Our results have significant implications for understanding the FASN role in human health and disease and provide evidence of therapeutic potential for Complex I inhibitors with fast systemic clearance. Our findings also highlight the continuing need for validation of small molecule inhibitors to distinguish high-quality chemical probes and to expand the understanding of their application.","INSTITUTE":"Wistar Institute","DEPARTMENT":"Molecular and Cellular Oncogenesis Program, Ellen and Ronald Caplan Cancer Center","LABORATORY":"Schug's Lab","LAST_NAME":"Mukha","FIRST_NAME":"Dzmitry","ADDRESS":"3601 Spruce St., Philadelphia, Pennsylvania 19104, USA","EMAIL":"dmukha@wistar.org","PHONE":"+12154956903","FUNDING_SOURCE":"This work was supported by grants from the National Institutes of Health (NIH) National Cancer Institute (NCI) DP2 CA249950-01 (Z.T.S.), NIH NCI P01 CA114046 (Z.T.S.), Melanoma Research Foundation 717173 (Z.T.S.), and Susan G. Komen CCR19608782 (Z.T.S.).","PUBLICATIONS":"Submission Pending","DOI":"http://dx.doi.org/10.21228/M8TM76","CONTRIBUTORS":"Dzmitry Mukha, Jena Dessain, Seamus O’Connor, Katherine Pniewski, Fabrizio Bertolazzi, Jeet Patel, Mary Mullins, Zachary T. Schug"},

"STUDY":{"STUDY_TITLE":"Metabolomics analysis of breast cancer cell lines treated with dimethylmalonate (DMM), GSK2194069, and their combination.","STUDY_SUMMARY":"Seven breast cancer cell lines (MDA-MB-468, SUM159PT, MCF7, HCC1806, MDA-MB-231, HS578T, CAL120) were treated with 5 mM DMM, 1 uM GSK2194069, and their combination, for 24 h. Intracellular samples were collected for the metabolomics analysis.","INSTITUTE":"Wistar Institute","DEPARTMENT":"Molecular and Cellular Oncogenesis Program, Ellen and Ronald Caplan Cancer Center","LABORATORY":"Schug's Lab","LAST_NAME":"Mukha","FIRST_NAME":"Dzmitry","ADDRESS":"3601 Spruce St, Philadelphia, PA 19104, USA","EMAIL":"dmukha@wistar.org","PHONE":"+12154956903","SUBMIT_DATE":"2024-08-21"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","GENDER":"Female","CELL_STRAIN_DETAILS":"MDA-MB-468, SUM159PT, MCF7, HCC1806, MDA-MB-231, HS578T, CAL120"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"40 CAL120 GSK 1 uM",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"43 CAL120 GSK 1 uM",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"39 CAL120 DMM 5 mM",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"42 CAL120 DMM 5 mM",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"41 CAL120 Combination",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"44 CAL120 Combination",
"Factors":{"Sample source":"CAL120 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-CAL120 Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"22 HCC1806 GSK 1 uM",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"25 HCC1806 GSK 1 uM",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"21 HCC1806 DMM 5 mM",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"24 HCC1806 DMM 5 mM",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"23 HCC1806 Combination",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"26 HCC1806 Combination",
"Factors":{"Sample source":"HCC1806 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HCC1806 Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"34 HS578T GSK 1 uM",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"37 HS578T GSK 1 uM",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"33 HS578T DMM 5 mM",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"36 HS578T DMM 5 mM",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"35 HS578T Combination",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"38 HS578T Combination",
"Factors":{"Sample source":"HS578T breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-HS578T Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"16 MCF7 GSK 1 uM",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"19 MCF7 GSK 1 uM",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"15 MCF7 DMM 5 mM",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"18 MCF7 DMM 5 mM",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"17 MCF7 Combination",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"20 MCF7 Combination",
"Factors":{"Sample source":"MCF7 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MCF7 Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"28 MDA-MB-231 GSK 1 uM",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"31 MDA-MB-231 GSK 1 uM",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"27 MDA-MB-231 DMM 5 mM",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"30 MDA-MB-231 DMM 5 mM",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"29 MDA-MB-231 Combination",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"32 MDA-MB-231 Combination",
"Factors":{"Sample source":"MDA-MB-231 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-231 Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"04 MDA-MB-468 GSK 1 uM",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"07 MDA-MB-468 GSK 1 uM",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"03 MDA-MB-468 DMM 5 mM",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"06 MDA-MB-468 DMM 5 mM",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"05 MDA-MB-468 Combination",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"08 MDA-MB-468 Combination",
"Factors":{"Sample source":"MDA-MB-468 breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-MDA-MB-468 Combination (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"01 Blank",
"Factors":{"Sample source":"NA","Sample Type":"Blank","Drug Treatment":"NA"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-Blank.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"46 Blank",
"Factors":{"Sample source":"NA","Sample Type":"Blank","Drug Treatment":"NA"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-Blank (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"02 DMEM/F12 no adds",
"Factors":{"Sample source":"NA","Sample Type":"QC","Drug Treatment":"NA"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-DMEM_F12 no adds.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"45 DMEM/F12 no adds",
"Factors":{"Sample source":"NA","Sample Type":"QC","Drug Treatment":"NA"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-DMEM_F12 no adds (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"10 SUM159PT GSK 1 uM",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT GSK 1 uM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"13 SUM159PT GSK 1 uM",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT GSK 1 uM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"09 SUM159PT DMM 5 mM",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT DMM 5 mM.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"12 SUM159PT DMM 5 mM",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT DMM 5 mM (2).mzML"}
},
{
"Subject ID":"-",
"Sample ID":"11 SUM159PT Combination",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT Combination.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"14 SUM159PT Combination",
"Factors":{"Sample source":"SUM159PT breast cancer cells","Sample Type":"Intracellular","Drug Treatment":"5 mM dimethylmalonate + 1 uM GSK214069"},
"Additional sample data":{"RAW_FILE_NAME(Raw File Name)":"20230318 Dima DMM GSK Seven cell lines.wiff","RAW_FILE_NAME(Raw File Name 1)":"20230318 Dima DMM GSK Seven cell lines-SUM159PT Combination (2).mzML"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"For intracellular metabolite samples, the medium was aspirated, and cells were washed with PBS volume matching the volume of the medium. Metabolites were extracted with ice-cold 80% methanol. The volume of the solvent was 500 µl per 6-cm Petri dish (scaled according to the ratio of surface areas for other cell containers). After adding the methanol solution, cells were scraped from the plates, and all the content was transferred to Eppendorf tubes.","COLLECTION_PROTOCOL_FILENAME":"DM_metabolomics_samples.txt","SAMPLE_TYPE":"Breast cancer cells","COLLECTION_METHOD":"80% methanol extraction","STORAGE_CONDITIONS":"-80℃","COLLECTION_VIALS":"1.5 ml plastic centrifuge tubes","STORAGE_VIALS":"1.5 ml plastic centrifuge tubes"},

"TREATMENT":{"TREATMENT_SUMMARY":"Cells were grown in RPMI-1640 supplemented with 10% dialyzed FBS and treated with various concentrations of rotenone for 24 h.","TREATMENT_COMPOUND":"Dimethylmalonate (DMM) and GSK2194069","TREATMENT_VEHICLE":"DMSO","CELL_GROWTH_CONTAINER":"6-cm Petri dishes","CELL_MEDIA":"RPMI-1640","CELL_ENVIR_COND":"37C, 5% CO2","CELL_PCT_CONFLUENCE":"~70%","CELL_MEDIA_LASTCHANGED":"24 h before collection"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Intracellular metabolites were extracted with ice-cold 80% methanol, and medium samples were extracted with 100% methanol. The samples were centrifuged at 18,000 g 4C for 20 min. After transferring the supernatant to new tubes, centrifugation was repeated with the same parameters.","SAMPLEPREP_PROTOCOL_FILENAME":"DM_metabolomics_samples.txt","PROCESSING_STORAGE_CONDITIONS":"4℃","EXTRACTION_METHOD":"80% methanol","EXTRACT_ENRICHMENT":"None","EXTRACT_CLEANUP":"None","EXTRACT_STORAGE":"-80℃","SAMPLE_RESUSPENSION":"None","SAMPLE_DERIVATIZATION":"None","SAMPLE_SPIKING":"None","SUBCELLULAR_LOCATION":"Intracellular metabolites and medium metabolites"},

"CHROMATOGRAPHY":{"INSTRUMENT_NAME":"Shimadzu 20AD","COLUMN_NAME":"Merck SeQuant ZIC-HILIC (150 x 2.1mm,5um)","COLUMN_PRESSURE":"900-3000 psi","COLUMN_TEMPERATURE":"40","FLOW_GRADIENT":"0-12.5 min, 80-30% B; 12.5-15 min, 30% B; 15-15.2 min, 30-80% B; 15.2-22.5 min, 80% B","FLOW_RATE":"0-20 min, 0.2 ml/min; 20-21 min 0.2-0.3 ml/min; 21-22 min, 0.3 ml/min; 22-22.1 min, 0.2 ml/min; 22.1-22.5 min, 0.2 ml/min","INJECTION_TEMPERATURE":"4","SAMPLE_INJECTION":"1-5 ul","SOLVENT_A":"100% Water; 0.01% ammonium hydroxide; 20 mM ammonium bicarbonate","SOLVENT_B":"100% Acetonitrile","CHROMATOGRAPHY_TYPE":"HILIC"},

"ANALYSIS":{"LABORATORY_NAME":"Schug's Lab","ANALYSIS_TYPE":"MS","ACQUISITION_DATE":"03/18/2023","SOFTWARE_VERSION":"SCIEX Analyst 1.7.3","OPERATOR_NAME":"Dzmitry Mukha, Ph.D.","DETECTOR_TYPE":"High Energy Dynode (HED) and High-Capacity CEM (Continuous Electron Multiplier)","DATA_FORMAT":".WIFF"},

"MS":{"INSTRUMENT_NAME":"ABI Sciex 5500 QTrap","INSTRUMENT_TYPE":"QTRAP","MS_TYPE":"ESI","MS_COMMENTS":"Data were analyzed with SCIEX Multiquant 3.0.3.","ION_MODE":"POSITIVE","CAPILLARY_TEMPERATURE":"500 °C","CAPILLARY_VOLTAGE":"4500","DRY_GAS_FLOW":"70","DRY_GAS_TEMP":"500 °C","ION_SOURCE_TEMPERATURE":"500 °C","ION_SPRAY_VOLTAGE":"4500","MASS_ACCURACY":"UNIT","SOURCE_TEMPERATURE":"500 °C","SPRAY_VOLTAGE":"4500","DESOLVATION_GAS_FLOW":"70","DESOLVATION_TEMPERATURE":"500 °C"},

"MS_METABOLITE_DATA":{
"Units":"Counts per second (cps)",

"Data":[{"Metabolite":"4-Hydroxyproline 68","40 CAL120 GSK 1 uM":"27900476.4900","43 CAL120 GSK 1 uM":"27434524.0300","39 CAL120 DMM 5 mM":"27699148.3500","42 CAL120 DMM 5 mM":"25303905.8800","41 CAL120 Combination":"23184697.6500","44 CAL120 Combination":"22995203.5800","22 HCC1806 GSK 1 uM":"58495760.9000","25 HCC1806 GSK 1 uM":"56201861.8000","21 HCC1806 DMM 5 mM":"64788527.7300","24 HCC1806 DMM 5 mM":"60068892.6400","23 HCC1806 Combination":"61092608.2200","26 HCC1806 Combination":"60505212.2500","34 HS578T GSK 1 uM":"45318576.9800","37 HS578T GSK 1 uM":"50747737.3900","33 HS578T DMM 5 mM":"38468014.4000","36 HS578T DMM 5 mM":"37156681.8900","35 HS578T Combination":"40942560.8500","38 HS578T Combination":"35730804.5000","16 MCF7 GSK 1 uM":"56658615.9100","19 MCF7 GSK 1 uM":"63911458.1900","15 MCF7 DMM 5 mM":"63334214.9900","18 MCF7 DMM 5 mM":"65754995.4700","17 MCF7 Combination":"53083446.9100","20 MCF7 Combination":"40285737.2700","28 MDA-MB-231 GSK 1 uM":"37480174.2700","31 MDA-MB-231 GSK 1 uM":"39021135.1900","27 MDA-MB-231 DMM 5 mM":"30810193.6000","30 MDA-MB-231 DMM 5 mM":"32286663.1300","29 MDA-MB-231 Combination":"28975581.2600","32 MDA-MB-231 Combination":"30548916.1600","04 MDA-MB-468 GSK 1 uM":"91004673.6400","07 MDA-MB-468 GSK 1 uM":"96390215.6400","03 MDA-MB-468 DMM 5 mM":"90670630.1300","06 MDA-MB-468 DMM 5 mM":"86388635.7000","05 MDA-MB-468 Combination":"81599788.5300","08 MDA-MB-468 Combination":"85335783.4100","01 Blank":"7249.5563","46 Blank":"7186.1366","02 DMEM/F12 no adds":"8595.2199","45 DMEM/F12 no adds":"17233.9058","10 SUM159PT GSK 1 uM":"33782412.0700","13 SUM159PT GSK 1 uM":"38281725.1900","09 SUM159PT DMM 5 mM":"32855557.6900","12 SUM159PT DMM 5 mM":"31692468.3900","11 SUM159PT Combination":"29079688.5700","14 SUM159PT Combination":"31436075.5600"},{"Metabolite":"Acetyl-CoA 303","40 CAL120 GSK 1 uM":"2104713.0630","43 CAL120 GSK 1 uM":"2225642.4690","39 CAL120 DMM 5 mM":"1897682.2400","42 CAL120 DMM 5 mM":"2057362.4810","41 CAL120 Combination":"1999419.6590","44 CAL120 Combination":"2351218.3970","22 HCC1806 GSK 1 uM":"2584022.4820","25 HCC1806 GSK 1 uM":"2422954.3410","21 HCC1806 DMM 5 mM":"1711070.2330","24 HCC1806 DMM 5 mM":"2066322.4960","23 HCC1806 Combination":"1913919.9760","26 HCC1806 Combination":"1840552.8630","34 HS578T GSK 1 uM":"682310.8832","37 HS578T GSK 1 uM":"709210.9174","33 HS578T DMM 5 mM":"709977.6261","36 HS578T DMM 5 mM":"738773.3636","35 HS578T Combination":"1036505.2030","38 HS578T Combination":"920044.4312","16 MCF7 GSK 1 uM":"2827358.7460","19 MCF7 GSK 1 uM":"3319789.1220","15 MCF7 DMM 5 mM":"2188468.7810","18 MCF7 DMM 5 mM":"1823790.1880","17 MCF7 Combination":"3407215.1150","20 MCF7 Combination":"2073789.2040","28 MDA-MB-231 GSK 1 uM":"2076116.4060","31 MDA-MB-231 GSK 1 uM":"2314068.1680","27 MDA-MB-231 DMM 5 mM":"2844679.5060","30 MDA-MB-231 DMM 5 mM":"2681128.0920","29 MDA-MB-231 Combination":"1844643.0150","32 MDA-MB-231 Combination":"2262178.3920","04 MDA-MB-468 GSK 1 uM":"6349249.3430","07 MDA-MB-468 GSK 1 uM":"7409226.7780","03 MDA-MB-468 DMM 5 mM":"6304383.9350","06 MDA-MB-468 DMM 5 mM":"6214826.6910","05 MDA-MB-468 Combination":"6885014.2230","08 MDA-MB-468 Combination":"6630741.6350","01 Blank":"205.9018","46 Blank":"809.1925","02 DMEM/F12 no adds":"591.9918","45 DMEM/F12 no adds":"1519.1393","10 SUM159PT GSK 1 uM":"2666833.4190","13 SUM159PT GSK 1 uM":"3321945.1390","09 SUM159PT DMM 5 mM":"2013325.9580","12 SUM159PT DMM 5 mM":"2067151.9620","11 SUM159PT Combination":"2292277.9150","14 SUM159PT Combination":"2428465.3230"},{"Metabolite":"Acetyl-CoA 428","40 CAL120 GSK 1 uM":"277934.7610","43 CAL120 GSK 1 uM":"332406.5090","39 CAL120 DMM 5 mM":"257235.4091","42 CAL120 DMM 5 mM":"278290.0571","41 CAL120 Combination":"275110.7062","44 CAL120 Combination":"339804.9804","22 HCC1806 GSK 1 uM":"373856.1443","25 HCC1806 GSK 1 uM":"350202.1186","21 HCC1806 DMM 5 mM":"249434.7305","24 HCC1806 DMM 5 mM":"292407.6108","23 HCC1806 Combination":"268438.1604","26 HCC1806 Combination":"256005.0398","34 HS578T GSK 1 uM":"98376.9921","37 HS578T GSK 1 uM":"102294.2967","33 HS578T DMM 5 mM":"91674.5434","36 HS578T DMM 5 mM":"102788.4027","35 HS578T Combination":"151811.7642","38 HS578T Combination":"138585.7905","16 MCF7 GSK 1 uM":"399139.3080","19 MCF7 GSK 1 uM":"457536.3768","15 MCF7 DMM 5 mM":"304911.4358","18 MCF7 DMM 5 mM":"256538.6114","17 MCF7 Combination":"535749.9385","20 MCF7 Combination":"285281.2441","28 MDA-MB-231 GSK 1 uM":"296138.7073","31 MDA-MB-231 GSK 1 uM":"315945.2847","27 MDA-MB-231 DMM 5 mM":"398201.3354","30 MDA-MB-231 DMM 5 mM":"357398.9840","29 MDA-MB-231 Combination":"240840.6196","32 MDA-MB-231 Combination":"323315.5509","04 MDA-MB-468 GSK 1 uM":"877978.7285","07 MDA-MB-468 GSK 1 uM":"1032507.0810","03 MDA-MB-468 DMM 5 mM":"868932.4997","06 MDA-MB-468 DMM 5 mM":"887705.2136","05 MDA-MB-468 Combination":"967783.8280","08 MDA-MB-468 Combination":"971225.2583","01 Blank":"","46 Blank":"179.5059","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"98.9583","10 SUM159PT GSK 1 uM":"378693.8137","13 SUM159PT GSK 1 uM":"451287.5372","09 SUM159PT DMM 5 mM":"279166.4886","12 SUM159PT DMM 5 mM":"283995.5528","11 SUM159PT Combination":"299108.9954","14 SUM159PT Combination":"327929.5099"},{"Metabolite":"Adenine 119","40 CAL120 GSK 1 uM":"364313.4359","43 CAL120 GSK 1 uM":"248871.0574","39 CAL120 DMM 5 mM":"217989.8235","42 CAL120 DMM 5 mM":"354352.7790","41 CAL120 Combination":"326051.1309","44 CAL120 Combination":"408554.1805","22 HCC1806 GSK 1 uM":"340047.6489","25 HCC1806 GSK 1 uM":"545969.1345","21 HCC1806 DMM 5 mM":"575803.9879","24 HCC1806 DMM 5 mM":"423546.8186","23 HCC1806 Combination":"589426.5352","26 HCC1806 Combination":"525044.8805","34 HS578T GSK 1 uM":"372539.2401","37 HS578T GSK 1 uM":"515135.4719","33 HS578T DMM 5 mM":"527142.3231","36 HS578T DMM 5 mM":"325305.2160","35 HS578T Combination":"606113.0879","38 HS578T Combination":"680265.8839","16 MCF7 GSK 1 uM":"148152.4344","19 MCF7 GSK 1 uM":"173338.8837","15 MCF7 DMM 5 mM":"185622.0268","18 MCF7 DMM 5 mM":"135980.1253","17 MCF7 Combination":"115727.9246","20 MCF7 Combination":"100075.2041","28 MDA-MB-231 GSK 1 uM":"1222106.9280","31 MDA-MB-231 GSK 1 uM":"813214.0468","27 MDA-MB-231 DMM 5 mM":"896180.9376","30 MDA-MB-231 DMM 5 mM":"953643.2993","29 MDA-MB-231 Combination":"1116879.2300","32 MDA-MB-231 Combination":"1432706.5040","04 MDA-MB-468 GSK 1 uM":"440720.8033","07 MDA-MB-468 GSK 1 uM":"399385.2496","03 MDA-MB-468 DMM 5 mM":"580969.6445","06 MDA-MB-468 DMM 5 mM":"549439.0953","05 MDA-MB-468 Combination":"409687.9247","08 MDA-MB-468 Combination":"566180.2162","01 Blank":"2811.7723","46 Blank":"25364.4422","02 DMEM/F12 no adds":"23859.4215","45 DMEM/F12 no adds":"13683.4654","10 SUM159PT GSK 1 uM":"450222.0177","13 SUM159PT GSK 1 uM":"484750.4761","09 SUM159PT DMM 5 mM":"166691.1070","12 SUM159PT DMM 5 mM":"396355.6249","11 SUM159PT Combination":"342950.7568","14 SUM159PT Combination":"369589.6739"},{"Metabolite":"Adenosylcobalamin 147","40 CAL120 GSK 1 uM":"2106.3750","43 CAL120 GSK 1 uM":"2966.0276","39 CAL120 DMM 5 mM":"1618.3929","42 CAL120 DMM 5 mM":"1944.4104","41 CAL120 Combination":"1848.2271","44 CAL120 Combination":"1352.9924","22 HCC1806 GSK 1 uM":"2051.2040","25 HCC1806 GSK 1 uM":"2276.3400","21 HCC1806 DMM 5 mM":"5013.2649","24 HCC1806 DMM 5 mM":"1794.2695","23 HCC1806 Combination":"1280.2867","26 HCC1806 Combination":"3135.1419","34 HS578T GSK 1 uM":"596.3858","37 HS578T GSK 1 uM":"904.7774","33 HS578T DMM 5 mM":"1148.0776","36 HS578T DMM 5 mM":"177.4573","35 HS578T Combination":"891.5230","38 HS578T Combination":"577.2951","16 MCF7 GSK 1 uM":"566.2645","19 MCF7 GSK 1 uM":"726.4658","15 MCF7 DMM 5 mM":"1575.7091","18 MCF7 DMM 5 mM":"1282.5962","17 MCF7 Combination":"948.1680","20 MCF7 Combination":"544.8019","28 MDA-MB-231 GSK 1 uM":"478.0388","31 MDA-MB-231 GSK 1 uM":"344.0931","27 MDA-MB-231 DMM 5 mM":"78.3747","30 MDA-MB-231 DMM 5 mM":"466.8916","29 MDA-MB-231 Combination":"795.3214","32 MDA-MB-231 Combination":"329.7447","04 MDA-MB-468 GSK 1 uM":"5827.0543","07 MDA-MB-468 GSK 1 uM":"5323.2913","03 MDA-MB-468 DMM 5 mM":"2666.8256","06 MDA-MB-468 DMM 5 mM":"4229.6832","05 MDA-MB-468 Combination":"3274.3891","08 MDA-MB-468 Combination":"4774.7363","01 Blank":"166.2366","46 Blank":"238.9409","02 DMEM/F12 no adds":"376.9502","45 DMEM/F12 no adds":"239.9516","10 SUM159PT GSK 1 uM":"2277.1264","13 SUM159PT GSK 1 uM":"5085.4290","09 SUM159PT DMM 5 mM":"3414.0833","12 SUM159PT DMM 5 mM":"3896.6095","11 SUM159PT Combination":"1227.0413","14 SUM159PT Combination":"1580.0554"},{"Metabolite":"Adenosylcobalamin 341","40 CAL120 GSK 1 uM":"1197.9778","43 CAL120 GSK 1 uM":"1441.5653","39 CAL120 DMM 5 mM":"302.0698","42 CAL120 DMM 5 mM":"884.9531","41 CAL120 Combination":"157.1946","44 CAL120 Combination":"605.5699","22 HCC1806 GSK 1 uM":"97.1764","25 HCC1806 GSK 1 uM":"1015.7549","21 HCC1806 DMM 5 mM":"196.6026","24 HCC1806 DMM 5 mM":"100.7200","23 HCC1806 Combination":"260.6451","26 HCC1806 Combination":"462.1018","34 HS578T GSK 1 uM":"195.7235","37 HS578T GSK 1 uM":"771.7958","33 HS578T DMM 5 mM":"95.6658","36 HS578T DMM 5 mM":"95.0859","35 HS578T Combination":"241.7829","38 HS578T Combination":"520.4728","16 MCF7 GSK 1 uM":"75.3972","19 MCF7 GSK 1 uM":"315.9963","15 MCF7 DMM 5 mM":"355.4269","18 MCF7 DMM 5 mM":"243.7141","17 MCF7 Combination":"401.7594","20 MCF7 Combination":"163.4315","28 MDA-MB-231 GSK 1 uM":"96.8959","31 MDA-MB-231 GSK 1 uM":"","27 MDA-MB-231 DMM 5 mM":"85.0578","30 MDA-MB-231 DMM 5 mM":"523.7152","29 MDA-MB-231 Combination":"225.4042","32 MDA-MB-231 Combination":"327.7369","04 MDA-MB-468 GSK 1 uM":"725.5641","07 MDA-MB-468 GSK 1 uM":"1605.6951","03 MDA-MB-468 DMM 5 mM":"378.7732","06 MDA-MB-468 DMM 5 mM":"91.4531","05 MDA-MB-468 Combination":"269.2359","08 MDA-MB-468 Combination":"356.2518","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"545.9694","13 SUM159PT GSK 1 uM":"509.5664","09 SUM159PT DMM 5 mM":"301.8539","12 SUM159PT DMM 5 mM":"1625.1934","11 SUM159PT Combination":"233.6311","14 SUM159PT Combination":"379.4177"},{"Metabolite":"ADP 136","40 CAL120 GSK 1 uM":"11550297.8300","43 CAL120 GSK 1 uM":"8799121.7420","39 CAL120 DMM 5 mM":"11026884.7200","42 CAL120 DMM 5 mM":"10608363.2000","41 CAL120 Combination":"10736032.7100","44 CAL120 Combination":"10994342.2100","22 HCC1806 GSK 1 uM":"14465421.7000","25 HCC1806 GSK 1 uM":"17209352.6100","21 HCC1806 DMM 5 mM":"14652695.0300","24 HCC1806 DMM 5 mM":"13824287.6400","23 HCC1806 Combination":"14055008.0900","26 HCC1806 Combination":"14700326.2200","34 HS578T GSK 1 uM":"5928268.0220","37 HS578T GSK 1 uM":"6115327.1190","33 HS578T DMM 5 mM":"4979247.9050","36 HS578T DMM 5 mM":"4551324.3540","35 HS578T Combination":"5908899.0010","38 HS578T Combination":"4198582.9450","16 MCF7 GSK 1 uM":"11957486.0700","19 MCF7 GSK 1 uM":"12368017.7500","15 MCF7 DMM 5 mM":"11397368.6700","18 MCF7 DMM 5 mM":"10495061.8300","17 MCF7 Combination":"11967645.4000","20 MCF7 Combination":"8839992.9500","28 MDA-MB-231 GSK 1 uM":"8861976.0610","31 MDA-MB-231 GSK 1 uM":"11726402.1600","27 MDA-MB-231 DMM 5 mM":"8588579.0650","30 MDA-MB-231 DMM 5 mM":"8775421.1010","29 MDA-MB-231 Combination":"7885134.3500","32 MDA-MB-231 Combination":"8615375.2780","04 MDA-MB-468 GSK 1 uM":"25147941.4700","07 MDA-MB-468 GSK 1 uM":"24599924.4100","03 MDA-MB-468 DMM 5 mM":"22605860.9400","06 MDA-MB-468 DMM 5 mM":"26591771.0700","05 MDA-MB-468 Combination":"22619454.2200","08 MDA-MB-468 Combination":"25611332.2800","01 Blank":"18526.5726","46 Blank":"184127.3401","02 DMEM/F12 no adds":"21164.5290","45 DMEM/F12 no adds":"189137.0027","10 SUM159PT GSK 1 uM":"13946083.7500","13 SUM159PT GSK 1 uM":"14708981.4200","09 SUM159PT DMM 5 mM":"15702170.6300","12 SUM159PT DMM 5 mM":"14703326.8000","11 SUM159PT Combination":"13058002.2000","14 SUM159PT Combination":"13651818.2200"},{"Metabolite":"ADP 97","40 CAL120 GSK 1 uM":"441483.0974","43 CAL120 GSK 1 uM":"397735.5562","39 CAL120 DMM 5 mM":"426843.9615","42 CAL120 DMM 5 mM":"424652.3788","41 CAL120 Combination":"393501.2054","44 CAL120 Combination":"407691.5644","22 HCC1806 GSK 1 uM":"561739.1873","25 HCC1806 GSK 1 uM":"653377.9248","21 HCC1806 DMM 5 mM":"568797.7852","24 HCC1806 DMM 5 mM":"566505.6610","23 HCC1806 Combination":"525126.7282","26 HCC1806 Combination":"613385.8363","34 HS578T GSK 1 uM":"228669.8097","37 HS578T GSK 1 uM":"225808.4759","33 HS578T DMM 5 mM":"204304.5081","36 HS578T DMM 5 mM":"191905.0752","35 HS578T Combination":"244523.5730","38 HS578T Combination":"160649.8446","16 MCF7 GSK 1 uM":"508554.2742","19 MCF7 GSK 1 uM":"464662.3180","15 MCF7 DMM 5 mM":"424265.3443","18 MCF7 DMM 5 mM":"411075.7647","17 MCF7 Combination":"450422.1347","20 MCF7 Combination":"352305.6284","28 MDA-MB-231 GSK 1 uM":"396337.4754","31 MDA-MB-231 GSK 1 uM":"487916.0376","27 MDA-MB-231 DMM 5 mM":"356138.8044","30 MDA-MB-231 DMM 5 mM":"338810.2033","29 MDA-MB-231 Combination":"331052.1106","32 MDA-MB-231 Combination":"347602.1290","04 MDA-MB-468 GSK 1 uM":"981389.8532","07 MDA-MB-468 GSK 1 uM":"938347.1913","03 MDA-MB-468 DMM 5 mM":"939545.6192","06 MDA-MB-468 DMM 5 mM":"971672.2019","05 MDA-MB-468 Combination":"934222.8133","08 MDA-MB-468 Combination":"965473.1556","01 Blank":"","46 Blank":"2609.1715","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"5300.8830","10 SUM159PT GSK 1 uM":"447365.1640","13 SUM159PT GSK 1 uM":"503731.1498","09 SUM159PT DMM 5 mM":"569619.1411","12 SUM159PT DMM 5 mM":"581498.0620","11 SUM159PT Combination":"480345.7723","14 SUM159PT Combination":"527550.4740"},{"Metabolite":"Alanine 30","40 CAL120 GSK 1 uM":"256825.0229","43 CAL120 GSK 1 uM":"281440.9418","39 CAL120 DMM 5 mM":"291305.8759","42 CAL120 DMM 5 mM":"286346.8502","41 CAL120 Combination":"254101.2217","44 CAL120 Combination":"255755.2916","22 HCC1806 GSK 1 uM":"709034.5831","25 HCC1806 GSK 1 uM":"712316.6776","21 HCC1806 DMM 5 mM":"588962.8872","24 HCC1806 DMM 5 mM":"635144.5172","23 HCC1806 Combination":"538693.8031","26 HCC1806 Combination":"545511.5605","34 HS578T GSK 1 uM":"105249.7036","37 HS578T GSK 1 uM":"97823.5807","33 HS578T DMM 5 mM":"69401.9443","36 HS578T DMM 5 mM":"77533.8406","35 HS578T Combination":"91007.5149","38 HS578T Combination":"81375.8776","16 MCF7 GSK 1 uM":"239492.2840","19 MCF7 GSK 1 uM":"278636.1633","15 MCF7 DMM 5 mM":"278430.7726","18 MCF7 DMM 5 mM":"260580.7380","17 MCF7 Combination":"299524.3239","20 MCF7 Combination":"229191.9628","28 MDA-MB-231 GSK 1 uM":"104427.9055","31 MDA-MB-231 GSK 1 uM":"104286.8720","27 MDA-MB-231 DMM 5 mM":"136266.8445","30 MDA-MB-231 DMM 5 mM":"137607.8227","29 MDA-MB-231 Combination":"139688.8131","32 MDA-MB-231 Combination":"151569.9157","04 MDA-MB-468 GSK 1 uM":"503137.1189","07 MDA-MB-468 GSK 1 uM":"455711.8643","03 MDA-MB-468 DMM 5 mM":"579020.8164","06 MDA-MB-468 DMM 5 mM":"482911.0546","05 MDA-MB-468 Combination":"546839.7576","08 MDA-MB-468 Combination":"505712.3134","01 Blank":"1218.2508","46 Blank":"4233.9017","02 DMEM/F12 no adds":"30650.7696","45 DMEM/F12 no adds":"25749.2208","10 SUM159PT GSK 1 uM":"548960.0554","13 SUM159PT GSK 1 uM":"729995.9747","09 SUM159PT DMM 5 mM":"646882.2116","12 SUM159PT DMM 5 mM":"610056.8477","11 SUM159PT Combination":"519493.3135","14 SUM159PT Combination":"550619.2252"},{"Metabolite":"Alanine 44","40 CAL120 GSK 1 uM":"32918127.7900","43 CAL120 GSK 1 uM":"34806682.4300","39 CAL120 DMM 5 mM":"31678667.1100","42 CAL120 DMM 5 mM":"27899032.0200","41 CAL120 Combination":"25836716.4500","44 CAL120 Combination":"26979841.3200","22 HCC1806 GSK 1 uM":"64220079.0900","25 HCC1806 GSK 1 uM":"62995787.0300","21 HCC1806 DMM 5 mM":"61771013.7100","24 HCC1806 DMM 5 mM":"62634666.4200","23 HCC1806 Combination":"58273499.6600","26 HCC1806 Combination":"58087305.4400","34 HS578T GSK 1 uM":"10821580.5500","37 HS578T GSK 1 uM":"10606446.4300","33 HS578T DMM 5 mM":"6141835.4560","36 HS578T DMM 5 mM":"6048756.6840","35 HS578T Combination":"6516735.1200","38 HS578T Combination":"5959555.0830","16 MCF7 GSK 1 uM":"23866394.3000","19 MCF7 GSK 1 uM":"27062381.6400","15 MCF7 DMM 5 mM":"28941383.3500","18 MCF7 DMM 5 mM":"29531823.9600","17 MCF7 Combination":"22564537.7200","20 MCF7 Combination":"15704653.7100","28 MDA-MB-231 GSK 1 uM":"6641533.7180","31 MDA-MB-231 GSK 1 uM":"7746728.8930","27 MDA-MB-231 DMM 5 mM":"9321982.4040","30 MDA-MB-231 DMM 5 mM":"9860321.4320","29 MDA-MB-231 Combination":"9185393.5970","32 MDA-MB-231 Combination":"9466295.4520","04 MDA-MB-468 GSK 1 uM":"130382027.7000","07 MDA-MB-468 GSK 1 uM":"134201331.2000","03 MDA-MB-468 DMM 5 mM":"133175949.7000","06 MDA-MB-468 DMM 5 mM":"127411689.2000","05 MDA-MB-468 Combination":"122538531.7000","08 MDA-MB-468 Combination":"122805282.9000","01 Blank":"3368.2506","46 Blank":"31038.0695","02 DMEM/F12 no adds":"8678563.2370","45 DMEM/F12 no adds":"10514743.7800","10 SUM159PT GSK 1 uM":"32081834.9500","13 SUM159PT GSK 1 uM":"41040378.9900","09 SUM159PT DMM 5 mM":"35713137.2900","12 SUM159PT DMM 5 mM":"34762014.5700","11 SUM159PT Combination":"31483406.9700","14 SUM159PT Combination":"31560061.3000"},{"Metabolite":"Alanine PAR POS","40 CAL120 GSK 1 uM":"46218131.0400","43 CAL120 GSK 1 uM":"46649734.0500","39 CAL120 DMM 5 mM":"44262609.7700","42 CAL120 DMM 5 mM":"39799970.4500","41 CAL120 Combination":"36141643.2800","44 CAL120 Combination":"39992736.0900","22 HCC1806 GSK 1 uM":"95865609.3300","25 HCC1806 GSK 1 uM":"101136125.7000","21 HCC1806 DMM 5 mM":"92980761.5800","24 HCC1806 DMM 5 mM":"87896025.9400","23 HCC1806 Combination":"89262597.9400","26 HCC1806 Combination":"87385303.1200","34 HS578T GSK 1 uM":"14085585.6700","37 HS578T GSK 1 uM":"14034483.7900","33 HS578T DMM 5 mM":"7828417.4530","36 HS578T DMM 5 mM":"8181350.4760","35 HS578T Combination":"9689516.6610","38 HS578T Combination":"7886153.4420","16 MCF7 GSK 1 uM":"34036822.0500","19 MCF7 GSK 1 uM":"41227814.9000","15 MCF7 DMM 5 mM":"41231269.6400","18 MCF7 DMM 5 mM":"40679881.6000","17 MCF7 Combination":"35847381.5300","20 MCF7 Combination":"22652557.1300","28 MDA-MB-231 GSK 1 uM":"9962822.6200","31 MDA-MB-231 GSK 1 uM":"12384828.7300","27 MDA-MB-231 DMM 5 mM":"15667603.8200","30 MDA-MB-231 DMM 5 mM":"15327586.8000","29 MDA-MB-231 Combination":"14324204.0900","32 MDA-MB-231 Combination":"14781255.5500","04 MDA-MB-468 GSK 1 uM":"153248771.4000","07 MDA-MB-468 GSK 1 uM":"156270845.4000","03 MDA-MB-468 DMM 5 mM":"165102537.5000","06 MDA-MB-468 DMM 5 mM":"154093754.2000","05 MDA-MB-468 Combination":"155464090.2000","08 MDA-MB-468 Combination":"152005709.6000","01 Blank":"331279.1830","46 Blank":"767346.4913","02 DMEM/F12 no adds":"9009948.7500","45 DMEM/F12 no adds":"10914291.5300","10 SUM159PT GSK 1 uM":"57901049.4000","13 SUM159PT GSK 1 uM":"71809985.9000","09 SUM159PT DMM 5 mM":"64275611.8300","12 SUM159PT DMM 5 mM":"61446879.5100","11 SUM159PT Combination":"55974641.0000","14 SUM159PT Combination":"56461846.4400"},{"Metabolite":"Asparagine 87","40 CAL120 GSK 1 uM":"7387107.0650","43 CAL120 GSK 1 uM":"6523825.0910","39 CAL120 DMM 5 mM":"5425421.9470","42 CAL120 DMM 5 mM":"4948298.5300","41 CAL120 Combination":"4219163.6370","44 CAL120 Combination":"4754000.0720","22 HCC1806 GSK 1 uM":"13847056.5700","25 HCC1806 GSK 1 uM":"13736990.9200","21 HCC1806 DMM 5 mM":"14906086.1300","24 HCC1806 DMM 5 mM":"14004763.9500","23 HCC1806 Combination":"14946690.7500","26 HCC1806 Combination":"14292610.2500","34 HS578T GSK 1 uM":"7228752.4630","37 HS578T GSK 1 uM":"8725672.6220","33 HS578T DMM 5 mM":"6168123.0460","36 HS578T DMM 5 mM":"5607748.7710","35 HS578T Combination":"6734214.8550","38 HS578T Combination":"5238301.5110","16 MCF7 GSK 1 uM":"5874556.4630","19 MCF7 GSK 1 uM":"7112561.0750","15 MCF7 DMM 5 mM":"8339908.2280","18 MCF7 DMM 5 mM":"8228670.1380","17 MCF7 Combination":"5938689.3330","20 MCF7 Combination":"4337360.7990","28 MDA-MB-231 GSK 1 uM":"3398849.0980","31 MDA-MB-231 GSK 1 uM":"3433726.1600","27 MDA-MB-231 DMM 5 mM":"2861969.4940","30 MDA-MB-231 DMM 5 mM":"2900116.2970","29 MDA-MB-231 Combination":"2768429.3170","32 MDA-MB-231 Combination":"2701043.7760","04 MDA-MB-468 GSK 1 uM":"10565235.0200","07 MDA-MB-468 GSK 1 uM":"10917281.1900","03 MDA-MB-468 DMM 5 mM":"10942752.7600","06 MDA-MB-468 DMM 5 mM":"10172123.3500","05 MDA-MB-468 Combination":"9636946.3370","08 MDA-MB-468 Combination":"10885758.5500","01 Blank":"3499.7189","46 Blank":"3038.2763","02 DMEM/F12 no adds":"1563222.0890","45 DMEM/F12 no adds":"1678870.2840","10 SUM159PT GSK 1 uM":"7962716.6350","13 SUM159PT GSK 1 uM":"9626891.8590","09 SUM159PT DMM 5 mM":"5751927.5070","12 SUM159PT DMM 5 mM":"5582026.0380","11 SUM159PT Combination":"4792867.8400","14 SUM159PT Combination":"5155814.9720"},{"Metabolite":"ATP 136","40 CAL120 GSK 1 uM":"41472321.3600","43 CAL120 GSK 1 uM":"40435071.0400","39 CAL120 DMM 5 mM":"37605192.5100","42 CAL120 DMM 5 mM":"36283183.8900","41 CAL120 Combination":"36161937.8500","44 CAL120 Combination":"34016714.8900","22 HCC1806 GSK 1 uM":"74449080.2900","25 HCC1806 GSK 1 uM":"79389038.5500","21 HCC1806 DMM 5 mM":"64021447.1800","24 HCC1806 DMM 5 mM":"67756891.3000","23 HCC1806 Combination":"66893551.8500","26 HCC1806 Combination":"69354959.8200","34 HS578T GSK 1 uM":"19671324.0600","37 HS578T GSK 1 uM":"19267796.1000","33 HS578T DMM 5 mM":"14341266.2400","36 HS578T DMM 5 mM":"12760659.1400","35 HS578T Combination":"17281604.5700","38 HS578T Combination":"12984289.9000","16 MCF7 GSK 1 uM":"28010040.9000","19 MCF7 GSK 1 uM":"35622160.0500","15 MCF7 DMM 5 mM":"30393603.4300","18 MCF7 DMM 5 mM":"29003876.1600","17 MCF7 Combination":"33009290.9900","20 MCF7 Combination":"19017463.6900","28 MDA-MB-231 GSK 1 uM":"36993965.6800","31 MDA-MB-231 GSK 1 uM":"38857433.6400","27 MDA-MB-231 DMM 5 mM":"37664036.6600","30 MDA-MB-231 DMM 5 mM":"35761031.6300","29 MDA-MB-231 Combination":"28700652.6400","32 MDA-MB-231 Combination":"34463219.1900","04 MDA-MB-468 GSK 1 uM":"89197124.2600","07 MDA-MB-468 GSK 1 uM":"90763658.4100","03 MDA-MB-468 DMM 5 mM":"74324867.0500","06 MDA-MB-468 DMM 5 mM":"80432812.2200","05 MDA-MB-468 Combination":"79086679.7800","08 MDA-MB-468 Combination":"78997949.4600","01 Blank":"6670.2766","46 Blank":"123138.1615","02 DMEM/F12 no adds":"6087.0571","45 DMEM/F12 no adds":"467609.4547","10 SUM159PT GSK 1 uM":"54178176.3300","13 SUM159PT GSK 1 uM":"63765168.9400","09 SUM159PT DMM 5 mM":"51946310.8900","12 SUM159PT DMM 5 mM":"50651560.4400","11 SUM159PT Combination":"46752243.2100","14 SUM159PT Combination":"50668305.7400"},{"Metabolite":"ATP 232","40 CAL120 GSK 1 uM":"1123229.8820","43 CAL120 GSK 1 uM":"1067174.5120","39 CAL120 DMM 5 mM":"999110.3564","42 CAL120 DMM 5 mM":"979092.6212","41 CAL120 Combination":"972855.2512","44 CAL120 Combination":"950891.0963","22 HCC1806 GSK 1 uM":"2169053.1200","25 HCC1806 GSK 1 uM":"2247647.1680","21 HCC1806 DMM 5 mM":"1843627.7390","24 HCC1806 DMM 5 mM":"1896861.3810","23 HCC1806 Combination":"1882792.8350","26 HCC1806 Combination":"1967367.8480","34 HS578T GSK 1 uM":"506401.5236","37 HS578T GSK 1 uM":"508692.7913","33 HS578T DMM 5 mM":"377018.2733","36 HS578T DMM 5 mM":"328884.3036","35 HS578T Combination":"472408.3987","38 HS578T Combination":"295666.1224","16 MCF7 GSK 1 uM":"747462.2505","19 MCF7 GSK 1 uM":"879892.2464","15 MCF7 DMM 5 mM":"870009.8861","18 MCF7 DMM 5 mM":"762846.9843","17 MCF7 Combination":"903198.4700","20 MCF7 Combination":"497637.2892","28 MDA-MB-231 GSK 1 uM":"997359.4325","31 MDA-MB-231 GSK 1 uM":"1042959.4560","27 MDA-MB-231 DMM 5 mM":"1052222.8000","30 MDA-MB-231 DMM 5 mM":"998958.7388","29 MDA-MB-231 Combination":"740542.5638","32 MDA-MB-231 Combination":"941112.6623","04 MDA-MB-468 GSK 1 uM":"2600126.8870","07 MDA-MB-468 GSK 1 uM":"2691345.1490","03 MDA-MB-468 DMM 5 mM":"2054978.3830","06 MDA-MB-468 DMM 5 mM":"2316998.2750","05 MDA-MB-468 Combination":"2188784.0920","08 MDA-MB-468 Combination":"2190955.7180","01 Blank":"","46 Blank":"326.7661","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"3633.7683","10 SUM159PT GSK 1 uM":"1539861.0320","13 SUM159PT GSK 1 uM":"1711297.7980","09 SUM159PT DMM 5 mM":"1328057.4650","12 SUM159PT DMM 5 mM":"1332273.5420","11 SUM159PT Combination":"1269706.9000","14 SUM159PT Combination":"1381615.5770"},{"Metabolite":"Beta-Alanine 30","40 CAL120 GSK 1 uM":"216215.6056","43 CAL120 GSK 1 uM":"215342.4867","39 CAL120 DMM 5 mM":"169986.8378","42 CAL120 DMM 5 mM":"190669.7968","41 CAL120 Combination":"164019.9472","44 CAL120 Combination":"211313.1065","22 HCC1806 GSK 1 uM":"308691.2790","25 HCC1806 GSK 1 uM":"371911.5994","21 HCC1806 DMM 5 mM":"233803.7807","24 HCC1806 DMM 5 mM":"237400.6301","23 HCC1806 Combination":"265067.8945","26 HCC1806 Combination":"237002.0268","34 HS578T GSK 1 uM":"253447.4967","37 HS578T GSK 1 uM":"242526.4495","33 HS578T DMM 5 mM":"245071.6596","36 HS578T DMM 5 mM":"220674.6143","35 HS578T Combination":"226395.1908","38 HS578T Combination":"67048.5144","16 MCF7 GSK 1 uM":"23915.0971","19 MCF7 GSK 1 uM":"31052.4894","15 MCF7 DMM 5 mM":"26585.0517","18 MCF7 DMM 5 mM":"27328.8324","17 MCF7 Combination":"299524.3239","20 MCF7 Combination":"229191.9628","28 MDA-MB-231 GSK 1 uM":"338170.8773","31 MDA-MB-231 GSK 1 uM":"301758.3814","27 MDA-MB-231 DMM 5 mM":"446507.3941","30 MDA-MB-231 DMM 5 mM":"370571.3339","29 MDA-MB-231 Combination":"271989.9166","32 MDA-MB-231 Combination":"272103.1743","04 MDA-MB-468 GSK 1 uM":"545548.4520","07 MDA-MB-468 GSK 1 uM":"573247.7275","03 MDA-MB-468 DMM 5 mM":"747943.5122","06 MDA-MB-468 DMM 5 mM":"695647.2473","05 MDA-MB-468 Combination":"719216.6207","08 MDA-MB-468 Combination":"682882.8011","01 Blank":"3614.0414","46 Blank":"1677.8311","02 DMEM/F12 no adds":"9708.1549","45 DMEM/F12 no adds":"1287.3134","10 SUM159PT GSK 1 uM":"1946516.8580","13 SUM159PT GSK 1 uM":"2423119.3910","09 SUM159PT DMM 5 mM":"1699761.2470","12 SUM159PT DMM 5 mM":"1821913.6750","11 SUM159PT Combination":"1497179.1330","14 SUM159PT Combination":"1684025.1650"},{"Metabolite":"Biotin 227","40 CAL120 GSK 1 uM":"1310560.1270","43 CAL120 GSK 1 uM":"1385487.8270","39 CAL120 DMM 5 mM":"1400222.0020","42 CAL120 DMM 5 mM":"1191109.6350","41 CAL120 Combination":"1311653.6790","44 CAL120 Combination":"1300143.5050","22 HCC1806 GSK 1 uM":"1908539.0930","25 HCC1806 GSK 1 uM":"1917061.7860","21 HCC1806 DMM 5 mM":"2162026.0570","24 HCC1806 DMM 5 mM":"1783039.1210","23 HCC1806 Combination":"1634140.4340","26 HCC1806 Combination":"1805533.6140","34 HS578T GSK 1 uM":"865849.6949","37 HS578T GSK 1 uM":"961125.7435","33 HS578T DMM 5 mM":"743336.2441","36 HS578T DMM 5 mM":"718764.9181","35 HS578T Combination":"949933.5444","38 HS578T Combination":"673573.3104","16 MCF7 GSK 1 uM":"3918871.1950","19 MCF7 GSK 1 uM":"4570239.4030","15 MCF7 DMM 5 mM":"2298327.8100","18 MCF7 DMM 5 mM":"2106891.6380","17 MCF7 Combination":"2541062.7240","20 MCF7 Combination":"1499966.2660","28 MDA-MB-231 GSK 1 uM":"1165952.6780","31 MDA-MB-231 GSK 1 uM":"1254840.2630","27 MDA-MB-231 DMM 5 mM":"993727.3469","30 MDA-MB-231 DMM 5 mM":"1128208.4760","29 MDA-MB-231 Combination":"1061381.7810","32 MDA-MB-231 Combination":"1122700.8120","04 MDA-MB-468 GSK 1 uM":"6671685.7430","07 MDA-MB-468 GSK 1 uM":"6571987.4020","03 MDA-MB-468 DMM 5 mM":"6456893.9000","06 MDA-MB-468 DMM 5 mM":"6216780.3630","05 MDA-MB-468 Combination":"5967966.3600","08 MDA-MB-468 Combination":"6438710.2790","01 Blank":"15059.5028","46 Blank":"27029.4096","02 DMEM/F12 no adds":"135162.3272","45 DMEM/F12 no adds":"167466.3142","10 SUM159PT GSK 1 uM":"1432488.9160","13 SUM159PT GSK 1 uM":"1529534.4880","09 SUM159PT DMM 5 mM":"1318431.7900","12 SUM159PT DMM 5 mM":"1199771.1020","11 SUM159PT Combination":"1113041.0610","14 SUM159PT Combination":"1217676.1910"},{"Metabolite":"Carnitine 102","40 CAL120 GSK 1 uM":"6482085.1530","43 CAL120 GSK 1 uM":"6580473.9000","39 CAL120 DMM 5 mM":"2921610.8140","42 CAL120 DMM 5 mM":"2929671.1320","41 CAL120 Combination":"3001149.4010","44 CAL120 Combination":"3038547.1410","22 HCC1806 GSK 1 uM":"4625526.8750","25 HCC1806 GSK 1 uM":"4488889.2390","21 HCC1806 DMM 5 mM":"1789039.1310","24 HCC1806 DMM 5 mM":"1723546.5300","23 HCC1806 Combination":"2095902.6790","26 HCC1806 Combination":"1957455.6440","34 HS578T GSK 1 uM":"755962.4744","37 HS578T GSK 1 uM":"723448.9509","33 HS578T DMM 5 mM":"454440.6746","36 HS578T DMM 5 mM":"455216.4225","35 HS578T Combination":"528051.1897","38 HS578T Combination":"94856.9434","16 MCF7 GSK 1 uM":"6545617.2740","19 MCF7 GSK 1 uM":"8910398.5180","15 MCF7 DMM 5 mM":"1058748.9360","18 MCF7 DMM 5 mM":"1005918.0090","17 MCF7 Combination":"2375043.0200","20 MCF7 Combination":"1448233.7620","28 MDA-MB-231 GSK 1 uM":"3086975.6570","31 MDA-MB-231 GSK 1 uM":"3547147.7060","27 MDA-MB-231 DMM 5 mM":"1280806.9610","30 MDA-MB-231 DMM 5 mM":"1251382.5290","29 MDA-MB-231 Combination":"962456.6336","32 MDA-MB-231 Combination":"1237238.0960","04 MDA-MB-468 GSK 1 uM":"9945440.6230","07 MDA-MB-468 GSK 1 uM":"10279216.4700","03 MDA-MB-468 DMM 5 mM":"2094877.3930","06 MDA-MB-468 DMM 5 mM":"2006392.6910","05 MDA-MB-468 Combination":"2844628.2230","08 MDA-MB-468 Combination":"2844889.1260","01 Blank":"","46 Blank":"1009.8403","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"274.1717","10 SUM159PT GSK 1 uM":"5387386.5600","13 SUM159PT GSK 1 uM":"6846309.2980","09 SUM159PT DMM 5 mM":"1880077.5150","12 SUM159PT DMM 5 mM":"1813365.4830","11 SUM159PT Combination":"2426033.8390","14 SUM159PT Combination":"2490129.3440"},{"Metabolite":"Carnitine 85","40 CAL120 GSK 1 uM":"21620093.4400","43 CAL120 GSK 1 uM":"22609639.6300","39 CAL120 DMM 5 mM":"10129496.8700","42 CAL120 DMM 5 mM":"9587711.6070","41 CAL120 Combination":"10242058.4200","44 CAL120 Combination":"10714282.9800","22 HCC1806 GSK 1 uM":"15033434.4400","25 HCC1806 GSK 1 uM":"15011957.5500","21 HCC1806 DMM 5 mM":"6016995.0490","24 HCC1806 DMM 5 mM":"6073832.6500","23 HCC1806 Combination":"7151774.1430","26 HCC1806 Combination":"6459610.0440","34 HS578T GSK 1 uM":"2774026.5460","37 HS578T GSK 1 uM":"2501954.9040","33 HS578T DMM 5 mM":"1495036.6240","36 HS578T DMM 5 mM":"1565178.9440","35 HS578T Combination":"1681602.6560","38 HS578T Combination":"321361.7020","16 MCF7 GSK 1 uM":"22222250.5800","19 MCF7 GSK 1 uM":"30438042.3300","15 MCF7 DMM 5 mM":"3571477.5040","18 MCF7 DMM 5 mM":"3405206.1420","17 MCF7 Combination":"8240337.3340","20 MCF7 Combination":"4817304.9230","28 MDA-MB-231 GSK 1 uM":"10286243.2600","31 MDA-MB-231 GSK 1 uM":"12491659.2900","27 MDA-MB-231 DMM 5 mM":"4193552.9150","30 MDA-MB-231 DMM 5 mM":"4150104.4410","29 MDA-MB-231 Combination":"3359942.2600","32 MDA-MB-231 Combination":"4346264.4320","04 MDA-MB-468 GSK 1 uM":"33816477.1200","07 MDA-MB-468 GSK 1 uM":"34943943.3100","03 MDA-MB-468 DMM 5 mM":"6794980.6390","06 MDA-MB-468 DMM 5 mM":"6770380.0640","05 MDA-MB-468 Combination":"9655720.8760","08 MDA-MB-468 Combination":"10016301.9300","01 Blank":"300.2157","46 Blank":"2489.6128","02 DMEM/F12 no adds":"971.9720","45 DMEM/F12 no adds":"1871.0440","10 SUM159PT GSK 1 uM":"18103318.0300","13 SUM159PT GSK 1 uM":"23055187.7600","09 SUM159PT DMM 5 mM":"6684725.2050","12 SUM159PT DMM 5 mM":"6696591.6110","11 SUM159PT Combination":"8058638.4560","14 SUM159PT Combination":"8730317.9840"},{"Metabolite":"Cerulenin 207","40 CAL120 GSK 1 uM":"178367.0088","43 CAL120 GSK 1 uM":"47161.8180","39 CAL120 DMM 5 mM":"107483.1138","42 CAL120 DMM 5 mM":"70084.0955","41 CAL120 Combination":"92456.3194","44 CAL120 Combination":"75189.8085","22 HCC1806 GSK 1 uM":"93459.6356","25 HCC1806 GSK 1 uM":"157782.8746","21 HCC1806 DMM 5 mM":"124098.7983","24 HCC1806 DMM 5 mM":"134450.1087","23 HCC1806 Combination":"135567.8900","26 HCC1806 Combination":"137668.9619","34 HS578T GSK 1 uM":"199132.8601","37 HS578T GSK 1 uM":"184853.0964","33 HS578T DMM 5 mM":"123896.3741","36 HS578T DMM 5 mM":"163283.1123","35 HS578T Combination":"165925.1946","38 HS578T Combination":"164885.4236","16 MCF7 GSK 1 uM":"116905.1392","19 MCF7 GSK 1 uM":"87433.5843","15 MCF7 DMM 5 mM":"164948.1840","18 MCF7 DMM 5 mM":"86530.2218","17 MCF7 Combination":"115059.8521","20 MCF7 Combination":"134434.4963","28 MDA-MB-231 GSK 1 uM":"107917.9819","31 MDA-MB-231 GSK 1 uM":"161773.0543","27 MDA-MB-231 DMM 5 mM":"85346.5506","30 MDA-MB-231 DMM 5 mM":"138069.3578","29 MDA-MB-231 Combination":"131924.2749","32 MDA-MB-231 Combination":"88289.8521","04 MDA-MB-468 GSK 1 uM":"169843.5984","07 MDA-MB-468 GSK 1 uM":"128663.2456","03 MDA-MB-468 DMM 5 mM":"166367.1966","06 MDA-MB-468 DMM 5 mM":"120944.2390","05 MDA-MB-468 Combination":"116147.3677","08 MDA-MB-468 Combination":"85415.0192","01 Blank":"174907.2343","46 Blank":"220235.2150","02 DMEM/F12 no adds":"868393.7415","45 DMEM/F12 no adds":"1050063.8800","10 SUM159PT GSK 1 uM":"131409.8036","13 SUM159PT GSK 1 uM":"155758.3185","09 SUM159PT DMM 5 mM":"134428.6257","12 SUM159PT DMM 5 mM":"100298.8368","11 SUM159PT Combination":"301494.8395","14 SUM159PT Combination":"116563.3434"},{"Metabolite":"Cerulenin 89","40 CAL120 GSK 1 uM":"1938032.1360","43 CAL120 GSK 1 uM":"700865.9875","39 CAL120 DMM 5 mM":"985655.8807","42 CAL120 DMM 5 mM":"841164.0405","41 CAL120 Combination":"1176122.1660","44 CAL120 Combination":"858813.4362","22 HCC1806 GSK 1 uM":"1372890.1740","25 HCC1806 GSK 1 uM":"1684516.1470","21 HCC1806 DMM 5 mM":"1372942.7590","24 HCC1806 DMM 5 mM":"1614105.1870","23 HCC1806 Combination":"1550566.8640","26 HCC1806 Combination":"1496876.2930","34 HS578T GSK 1 uM":"2251287.2000","37 HS578T GSK 1 uM":"2011963.6440","33 HS578T DMM 5 mM":"1587763.0850","36 HS578T DMM 5 mM":"1737621.8160","35 HS578T Combination":"1860779.1440","38 HS578T Combination":"1877045.9180","16 MCF7 GSK 1 uM":"1454379.2030","19 MCF7 GSK 1 uM":"1015409.1920","15 MCF7 DMM 5 mM":"2267381.4890","18 MCF7 DMM 5 mM":"1065934.3240","17 MCF7 Combination":"1450222.3020","20 MCF7 Combination":"1695764.9640","28 MDA-MB-231 GSK 1 uM":"1013285.5690","31 MDA-MB-231 GSK 1 uM":"1741989.2340","27 MDA-MB-231 DMM 5 mM":"1012616.0010","30 MDA-MB-231 DMM 5 mM":"1669258.7760","29 MDA-MB-231 Combination":"1702974.3120","32 MDA-MB-231 Combination":"1080212.0530","04 MDA-MB-468 GSK 1 uM":"2141985.8320","07 MDA-MB-468 GSK 1 uM":"1674809.9240","03 MDA-MB-468 DMM 5 mM":"1925364.4510","06 MDA-MB-468 DMM 5 mM":"1370425.3130","05 MDA-MB-468 Combination":"1441384.6230","08 MDA-MB-468 Combination":"914081.9941","01 Blank":"1571734.2600","46 Blank":"1828024.5990","02 DMEM/F12 no adds":"92885.9347","45 DMEM/F12 no adds":"102007.5337","10 SUM159PT GSK 1 uM":"1600707.0670","13 SUM159PT GSK 1 uM":"1701188.2230","09 SUM159PT DMM 5 mM":"1975596.4930","12 SUM159PT DMM 5 mM":"1268474.4660","11 SUM159PT Combination":"3676287.8160","14 SUM159PT Combination":"1561072.5810"},{"Metabolite":"Choline 60","40 CAL120 GSK 1 uM":"10246402.3800","43 CAL120 GSK 1 uM":"10293868.9000","39 CAL120 DMM 5 mM":"6065056.1820","42 CAL120 DMM 5 mM":"5368632.3440","41 CAL120 Combination":"6356911.8250","44 CAL120 Combination":"5361982.5620","22 HCC1806 GSK 1 uM":"15016937.9700","25 HCC1806 GSK 1 uM":"18437728.9500","21 HCC1806 DMM 5 mM":"6805956.4980","24 HCC1806 DMM 5 mM":"6770983.4270","23 HCC1806 Combination":"9315456.7110","26 HCC1806 Combination":"9773418.3610","34 HS578T GSK 1 uM":"3399079.1970","37 HS578T GSK 1 uM":"4346696.3300","33 HS578T DMM 5 mM":"2541088.8880","36 HS578T DMM 5 mM":"1963379.0380","35 HS578T Combination":"3174415.8200","38 HS578T Combination":"3076270.0480","16 MCF7 GSK 1 uM":"9637390.1790","19 MCF7 GSK 1 uM":"7157726.0600","15 MCF7 DMM 5 mM":"4299056.6660","18 MCF7 DMM 5 mM":"5142851.6490","17 MCF7 Combination":"6806245.2660","20 MCF7 Combination":"6391034.8350","28 MDA-MB-231 GSK 1 uM":"6298961.6560","31 MDA-MB-231 GSK 1 uM":"4547806.8400","27 MDA-MB-231 DMM 5 mM":"5214014.8900","30 MDA-MB-231 DMM 5 mM":"5354222.3820","29 MDA-MB-231 Combination":"6281958.4930","32 MDA-MB-231 Combination":"5556673.1650","04 MDA-MB-468 GSK 1 uM":"15882373.1000","07 MDA-MB-468 GSK 1 uM":"15749015.3100","03 MDA-MB-468 DMM 5 mM":"11655528.4200","06 MDA-MB-468 DMM 5 mM":"10677602.0800","05 MDA-MB-468 Combination":"14394331.5400","08 MDA-MB-468 Combination":"13898149.7900","01 Blank":"1465.7084","46 Blank":"22136.5948","02 DMEM/F12 no adds":"66076224.2800","45 DMEM/F12 no adds":"67756493.7200","10 SUM159PT GSK 1 uM":"23172858.9000","13 SUM159PT GSK 1 uM":"25227393.5300","09 SUM159PT DMM 5 mM":"13192598.1600","12 SUM159PT DMM 5 mM":"13985699.0600","11 SUM159PT Combination":"18500043.8600","14 SUM159PT Combination":"22242082.5300"},{"Metabolite":"Citraconic 113","40 CAL120 GSK 1 uM":"69952.0195","43 CAL120 GSK 1 uM":"124806.0985","39 CAL120 DMM 5 mM":"87593.9510","42 CAL120 DMM 5 mM":"109515.0785","41 CAL120 Combination":"88523.5865","44 CAL120 Combination":"132295.3855","22 HCC1806 GSK 1 uM":"63085.5765","25 HCC1806 GSK 1 uM":"83034.6035","21 HCC1806 DMM 5 mM":"133725.5340","24 HCC1806 DMM 5 mM":"128149.3075","23 HCC1806 Combination":"112439.6295","26 HCC1806 Combination":"112699.9045","34 HS578T GSK 1 uM":"118565.9250","37 HS578T GSK 1 uM":"123041.2670","33 HS578T DMM 5 mM":"185337.3480","36 HS578T DMM 5 mM":"196264.3115","35 HS578T Combination":"141027.5285","38 HS578T Combination":"103492.4430","16 MCF7 GSK 1 uM":"126542.2755","19 MCF7 GSK 1 uM":"117800.8075","15 MCF7 DMM 5 mM":"214341.3480","18 MCF7 DMM 5 mM":"221779.6560","17 MCF7 Combination":"137335.7225","20 MCF7 Combination":"134196.9880","28 MDA-MB-231 GSK 1 uM":"105127.5625","31 MDA-MB-231 GSK 1 uM":"106354.7655","27 MDA-MB-231 DMM 5 mM":"91571.1405","30 MDA-MB-231 DMM 5 mM":"157736.4545","29 MDA-MB-231 Combination":"154333.3865","32 MDA-MB-231 Combination":"175526.5340","04 MDA-MB-468 GSK 1 uM":"145796.1375","07 MDA-MB-468 GSK 1 uM":"140374.3740","03 MDA-MB-468 DMM 5 mM":"121062.2625","06 MDA-MB-468 DMM 5 mM":"104519.5850","05 MDA-MB-468 Combination":"126076.7960","08 MDA-MB-468 Combination":"109338.6505","01 Blank":"111254.1045","46 Blank":"115454.0335","02 DMEM/F12 no adds":"3859.4385","45 DMEM/F12 no adds":"2802.2865","10 SUM159PT GSK 1 uM":"124493.0145","13 SUM159PT GSK 1 uM":"150746.1140","09 SUM159PT DMM 5 mM":"174225.6875","12 SUM159PT DMM 5 mM":"119610.5270","11 SUM159PT Combination":"288874.5080","14 SUM159PT Combination":"289626.0355"},{"Metabolite":"Citrulline 113","40 CAL120 GSK 1 uM":"17191.6309","43 CAL120 GSK 1 uM":"12386.4119","39 CAL120 DMM 5 mM":"8988.6317","42 CAL120 DMM 5 mM":"8257.0103","41 CAL120 Combination":"4725.1622","44 CAL120 Combination":"11816.9485","22 HCC1806 GSK 1 uM":"15311.4490","25 HCC1806 GSK 1 uM":"15092.1426","21 HCC1806 DMM 5 mM":"18176.4226","24 HCC1806 DMM 5 mM":"12420.7115","23 HCC1806 Combination":"19485.7600","26 HCC1806 Combination":"9826.6852","34 HS578T GSK 1 uM":"22747.9891","37 HS578T GSK 1 uM":"18461.1101","33 HS578T DMM 5 mM":"8501.5020","36 HS578T DMM 5 mM":"12281.0212","35 HS578T Combination":"19007.8931","38 HS578T Combination":"12635.0147","16 MCF7 GSK 1 uM":"2305.6582","19 MCF7 GSK 1 uM":"9121.9572","15 MCF7 DMM 5 mM":"4125.8474","18 MCF7 DMM 5 mM":"5975.5991","17 MCF7 Combination":"2952.9358","20 MCF7 Combination":"4163.0616","28 MDA-MB-231 GSK 1 uM":"3209.0501","31 MDA-MB-231 GSK 1 uM":"5469.7918","27 MDA-MB-231 DMM 5 mM":"5008.8297","30 MDA-MB-231 DMM 5 mM":"4193.9056","29 MDA-MB-231 Combination":"8275.5736","32 MDA-MB-231 Combination":"7231.0507","04 MDA-MB-468 GSK 1 uM":"9151.3259","07 MDA-MB-468 GSK 1 uM":"6217.6706","03 MDA-MB-468 DMM 5 mM":"7191.1305","06 MDA-MB-468 DMM 5 mM":"6466.5469","05 MDA-MB-468 Combination":"8915.5174","08 MDA-MB-468 Combination":"15120.2667","01 Blank":"315.4587","46 Blank":"1761.8365","02 DMEM/F12 no adds":"3050.3982","45 DMEM/F12 no adds":"2728.1246","10 SUM159PT GSK 1 uM":"10336.2836","13 SUM159PT GSK 1 uM":"8014.5876","09 SUM159PT DMM 5 mM":"7766.3847","12 SUM159PT DMM 5 mM":"5524.9377","11 SUM159PT Combination":"6946.3648","14 SUM159PT Combination":"7906.1553"},{"Metabolite":"Citrulline 70","40 CAL120 GSK 1 uM":"538947.3270","43 CAL120 GSK 1 uM":"404072.9358","39 CAL120 DMM 5 mM":"271552.8056","42 CAL120 DMM 5 mM":"280677.6506","41 CAL120 Combination":"270129.3502","44 CAL120 Combination":"334631.8400","22 HCC1806 GSK 1 uM":"454455.6815","25 HCC1806 GSK 1 uM":"365382.0135","21 HCC1806 DMM 5 mM":"424739.6290","24 HCC1806 DMM 5 mM":"337375.1301","23 HCC1806 Combination":"554526.7460","26 HCC1806 Combination":"321636.2467","34 HS578T GSK 1 uM":"608531.8066","37 HS578T GSK 1 uM":"490624.9692","33 HS578T DMM 5 mM":"430485.1709","36 HS578T DMM 5 mM":"445751.2753","35 HS578T Combination":"548984.8679","38 HS578T Combination":"413791.9539","16 MCF7 GSK 1 uM":"131120.4991","19 MCF7 GSK 1 uM":"229684.8003","15 MCF7 DMM 5 mM":"94974.2128","18 MCF7 DMM 5 mM":"193141.0764","17 MCF7 Combination":"151715.1826","20 MCF7 Combination":"159738.7068","28 MDA-MB-231 GSK 1 uM":"168520.0400","31 MDA-MB-231 GSK 1 uM":"141576.3004","27 MDA-MB-231 DMM 5 mM":"166483.1928","30 MDA-MB-231 DMM 5 mM":"141961.0851","29 MDA-MB-231 Combination":"182826.3776","32 MDA-MB-231 Combination":"136315.7242","04 MDA-MB-468 GSK 1 uM":"285936.1677","07 MDA-MB-468 GSK 1 uM":"249315.1388","03 MDA-MB-468 DMM 5 mM":"270649.7717","06 MDA-MB-468 DMM 5 mM":"224387.4346","05 MDA-MB-468 Combination":"217094.0910","08 MDA-MB-468 Combination":"422517.2087","01 Blank":"4081.3341","46 Blank":"4423.9617","02 DMEM/F12 no adds":"63424.0712","45 DMEM/F12 no adds":"71563.9922","10 SUM159PT GSK 1 uM":"262790.2021","13 SUM159PT GSK 1 uM":"227883.4113","09 SUM159PT DMM 5 mM":"253281.3230","12 SUM159PT DMM 5 mM":"182384.9899","11 SUM159PT Combination":"216307.7119","14 SUM159PT Combination":"188331.3029"},{"Metabolite":"Cyanocobalamin 147","40 CAL120 GSK 1 uM":"3185.0850","43 CAL120 GSK 1 uM":"4521.1015","39 CAL120 DMM 5 mM":"6157.4733","42 CAL120 DMM 5 mM":"4577.2129","41 CAL120 Combination":"3619.0936","44 CAL120 Combination":"5172.2784","22 HCC1806 GSK 1 uM":"8872.6054","25 HCC1806 GSK 1 uM":"5601.1846","21 HCC1806 DMM 5 mM":"10531.3858","24 HCC1806 DMM 5 mM":"2963.6846","23 HCC1806 Combination":"4420.4005","26 HCC1806 Combination":"2682.4755","34 HS578T GSK 1 uM":"2630.9262","37 HS578T GSK 1 uM":"1583.7445","33 HS578T DMM 5 mM":"2086.3966","36 HS578T DMM 5 mM":"1409.7028","35 HS578T Combination":"1680.3516","38 HS578T Combination":"2341.0719","16 MCF7 GSK 1 uM":"1749.8845","19 MCF7 GSK 1 uM":"1201.8336","15 MCF7 DMM 5 mM":"1788.6582","18 MCF7 DMM 5 mM":"12474.0705","17 MCF7 Combination":"2685.2184","20 MCF7 Combination":"1829.8776","28 MDA-MB-231 GSK 1 uM":"7914.6796","31 MDA-MB-231 GSK 1 uM":"3126.1974","27 MDA-MB-231 DMM 5 mM":"2019.0291","30 MDA-MB-231 DMM 5 mM":"5017.7675","29 MDA-MB-231 Combination":"3251.4492","32 MDA-MB-231 Combination":"2381.4395","04 MDA-MB-468 GSK 1 uM":"13969.3093","07 MDA-MB-468 GSK 1 uM":"16528.2922","03 MDA-MB-468 DMM 5 mM":"16114.0406","06 MDA-MB-468 DMM 5 mM":"13258.5970","05 MDA-MB-468 Combination":"9001.7917","08 MDA-MB-468 Combination":"27786.5119","01 Blank":"117.0022","46 Blank":"269.6531","02 DMEM/F12 no adds":"1403801.2460","45 DMEM/F12 no adds":"1722709.4950","10 SUM159PT GSK 1 uM":"2375.1049","13 SUM159PT GSK 1 uM":"2893.8291","09 SUM159PT DMM 5 mM":"2022.0145","12 SUM159PT DMM 5 mM":"1689.4022","11 SUM159PT Combination":"2013.8181","14 SUM159PT Combination":"828.0270"},{"Metabolite":"Cyanocobalamin 457","40 CAL120 GSK 1 uM":"","43 CAL120 GSK 1 uM":"67.4497","39 CAL120 DMM 5 mM":"329.0357","42 CAL120 DMM 5 mM":"375.7893","41 CAL120 Combination":"76.1872","44 CAL120 Combination":"87.0727","22 HCC1806 GSK 1 uM":"1015.8376","25 HCC1806 GSK 1 uM":"793.7623","21 HCC1806 DMM 5 mM":"282.4747","24 HCC1806 DMM 5 mM":"","23 HCC1806 Combination":"285.5591","26 HCC1806 Combination":"145.2237","34 HS578T GSK 1 uM":"","37 HS578T GSK 1 uM":"","33 HS578T DMM 5 mM":"281.9440","36 HS578T DMM 5 mM":"","35 HS578T Combination":"71.7956","38 HS578T Combination":"","16 MCF7 GSK 1 uM":"215.3806","19 MCF7 GSK 1 uM":"","15 MCF7 DMM 5 mM":"","18 MCF7 DMM 5 mM":"583.4992","17 MCF7 Combination":"","20 MCF7 Combination":"","28 MDA-MB-231 GSK 1 uM":"219.9635","31 MDA-MB-231 GSK 1 uM":"","27 MDA-MB-231 DMM 5 mM":"66.0330","30 MDA-MB-231 DMM 5 mM":"305.5832","29 MDA-MB-231 Combination":"69.8925","32 MDA-MB-231 Combination":"","04 MDA-MB-468 GSK 1 uM":"1064.5949","07 MDA-MB-468 GSK 1 uM":"2434.7687","03 MDA-MB-468 DMM 5 mM":"1006.7080","06 MDA-MB-468 DMM 5 mM":"610.7096","05 MDA-MB-468 Combination":"1078.7731","08 MDA-MB-468 Combination":"2219.2644","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"175490.6264","45 DMEM/F12 no adds":"190763.1751","10 SUM159PT GSK 1 uM":"","13 SUM159PT GSK 1 uM":"","09 SUM159PT DMM 5 mM":"","12 SUM159PT DMM 5 mM":"","11 SUM159PT Combination":"","14 SUM159PT Combination":""},{"Metabolite":"Cysteine 76","40 CAL120 GSK 1 uM":"13433.7814","43 CAL120 GSK 1 uM":"11490.2027","39 CAL120 DMM 5 mM":"24650.7002","42 CAL120 DMM 5 mM":"24204.1743","41 CAL120 Combination":"13412.9291","44 CAL120 Combination":"4826.5772","22 HCC1806 GSK 1 uM":"27657.9479","25 HCC1806 GSK 1 uM":"16834.8599","21 HCC1806 DMM 5 mM":"18677.0992","24 HCC1806 DMM 5 mM":"32888.6281","23 HCC1806 Combination":"59560.3648","26 HCC1806 Combination":"95362.3971","34 HS578T GSK 1 uM":"6376.3284","37 HS578T GSK 1 uM":"43849.8812","33 HS578T DMM 5 mM":"9432.5574","36 HS578T DMM 5 mM":"19284.7619","35 HS578T Combination":"8001.5392","38 HS578T Combination":"21066.7786","16 MCF7 GSK 1 uM":"7323.7045","19 MCF7 GSK 1 uM":"34013.6962","15 MCF7 DMM 5 mM":"37340.8295","18 MCF7 DMM 5 mM":"39097.9521","17 MCF7 Combination":"34772.4159","20 MCF7 Combination":"24063.5274","28 MDA-MB-231 GSK 1 uM":"41275.9408","31 MDA-MB-231 GSK 1 uM":"33756.5689","27 MDA-MB-231 DMM 5 mM":"172847.8506","30 MDA-MB-231 DMM 5 mM":"28545.8293","29 MDA-MB-231 Combination":"60523.9178","32 MDA-MB-231 Combination":"18277.2429","04 MDA-MB-468 GSK 1 uM":"57957.0457","07 MDA-MB-468 GSK 1 uM":"73145.5549","03 MDA-MB-468 DMM 5 mM":"42746.5808","06 MDA-MB-468 DMM 5 mM":"49730.0295","05 MDA-MB-468 Combination":"84937.4062","08 MDA-MB-468 Combination":"86927.2637","01 Blank":"234.2235","46 Blank":"5691.8200","02 DMEM/F12 no adds":"223256.1641","45 DMEM/F12 no adds":"280166.8609","10 SUM159PT GSK 1 uM":"18126.7132","13 SUM159PT GSK 1 uM":"25199.0348","09 SUM159PT DMM 5 mM":"19994.3556","12 SUM159PT DMM 5 mM":"13033.5417","11 SUM159PT Combination":"8146.0621","14 SUM159PT Combination":"45991.4957"},{"Metabolite":"Cysteine PAR POS","40 CAL120 GSK 1 uM":"22471.9268","43 CAL120 GSK 1 uM":"122863.9743","39 CAL120 DMM 5 mM":"177827.8028","42 CAL120 DMM 5 mM":"15660.4852","41 CAL120 Combination":"","44 CAL120 Combination":"76127.0553","22 HCC1806 GSK 1 uM":"553663.1310","25 HCC1806 GSK 1 uM":"26417.4608","21 HCC1806 DMM 5 mM":"106471.2870","24 HCC1806 DMM 5 mM":"93129.3262","23 HCC1806 Combination":"74719.0563","26 HCC1806 Combination":"112012.2236","34 HS578T GSK 1 uM":"48807.9349","37 HS578T GSK 1 uM":"146623.2081","33 HS578T DMM 5 mM":"93232.9475","36 HS578T DMM 5 mM":"42444.2312","35 HS578T Combination":"84751.2884","38 HS578T Combination":"89361.5759","16 MCF7 GSK 1 uM":"58528.8236","19 MCF7 GSK 1 uM":"41011.3871","15 MCF7 DMM 5 mM":"120482.3353","18 MCF7 DMM 5 mM":"94641.9852","17 MCF7 Combination":"40103.7237","20 MCF7 Combination":"24659.8876","28 MDA-MB-231 GSK 1 uM":"51182.3744","31 MDA-MB-231 GSK 1 uM":"83190.2454","27 MDA-MB-231 DMM 5 mM":"47464.3038","30 MDA-MB-231 DMM 5 mM":"30119.3489","29 MDA-MB-231 Combination":"102186.2562","32 MDA-MB-231 Combination":"19020.1217","04 MDA-MB-468 GSK 1 uM":"337481.8329","07 MDA-MB-468 GSK 1 uM":"318229.3268","03 MDA-MB-468 DMM 5 mM":"237667.6025","06 MDA-MB-468 DMM 5 mM":"156266.1059","05 MDA-MB-468 Combination":"162661.7662","08 MDA-MB-468 Combination":"204960.4720","01 Blank":"10513.7360","46 Blank":"181607.7130","02 DMEM/F12 no adds":"1588856.1940","45 DMEM/F12 no adds":"1928778.4720","10 SUM159PT GSK 1 uM":"368478.5651","13 SUM159PT GSK 1 uM":"65578.5327","09 SUM159PT DMM 5 mM":"64710.4548","12 SUM159PT DMM 5 mM":"40364.7793","11 SUM159PT Combination":"185625.2315","14 SUM159PT Combination":"80675.7437"},{"Metabolite":"Cytidine 112","40 CAL120 GSK 1 uM":"764505.5962","43 CAL120 GSK 1 uM":"699167.8457","39 CAL120 DMM 5 mM":"680849.0997","42 CAL120 DMM 5 mM":"729576.8142","41 CAL120 Combination":"819778.6585","44 CAL120 Combination":"834634.3613","22 HCC1806 GSK 1 uM":"116598.7981","25 HCC1806 GSK 1 uM":"493397.0404","21 HCC1806 DMM 5 mM":"605779.5603","24 HCC1806 DMM 5 mM":"136630.2524","23 HCC1806 Combination":"387683.4404","26 HCC1806 Combination":"494387.5828","34 HS578T GSK 1 uM":"614620.0602","37 HS578T GSK 1 uM":"630941.5587","33 HS578T DMM 5 mM":"705551.5008","36 HS578T DMM 5 mM":"817776.9176","35 HS578T Combination":"1006726.0760","38 HS578T Combination":"979816.9764","16 MCF7 GSK 1 uM":"788331.6423","19 MCF7 GSK 1 uM":"981324.5528","15 MCF7 DMM 5 mM":"845007.9645","18 MCF7 DMM 5 mM":"1018058.7560","17 MCF7 Combination":"964422.7072","20 MCF7 Combination":"570471.6078","28 MDA-MB-231 GSK 1 uM":"1320822.2260","31 MDA-MB-231 GSK 1 uM":"1246261.3230","27 MDA-MB-231 DMM 5 mM":"846802.5100","30 MDA-MB-231 DMM 5 mM":"907582.3754","29 MDA-MB-231 Combination":"1189215.8040","32 MDA-MB-231 Combination":"1139610.0460","04 MDA-MB-468 GSK 1 uM":"2081414.4440","07 MDA-MB-468 GSK 1 uM":"2080902.5810","03 MDA-MB-468 DMM 5 mM":"1704970.9110","06 MDA-MB-468 DMM 5 mM":"2142790.3040","05 MDA-MB-468 Combination":"1237962.7680","08 MDA-MB-468 Combination":"2317280.1890","01 Blank":"1152.3081","46 Blank":"4799.4678","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"930008.4476","13 SUM159PT GSK 1 uM":"1179176.6240","09 SUM159PT DMM 5 mM":"675025.5756","12 SUM159PT DMM 5 mM":"881088.4443","11 SUM159PT Combination":"824729.6718","14 SUM159PT Combination":"893647.7164"},{"Metabolite":"Dimethylmalonate 101","40 CAL120 GSK 1 uM":"81279.8969","43 CAL120 GSK 1 uM":"42307.2860","39 CAL120 DMM 5 mM":"836772.2705","42 CAL120 DMM 5 mM":"452599.6652","41 CAL120 Combination":"443417.8200","44 CAL120 Combination":"283357.5601","22 HCC1806 GSK 1 uM":"33228.3081","25 HCC1806 GSK 1 uM":"70349.0961","21 HCC1806 DMM 5 mM":"1446782.7180","24 HCC1806 DMM 5 mM":"520758.1197","23 HCC1806 Combination":"408782.1554","26 HCC1806 Combination":"551764.5355","34 HS578T GSK 1 uM":"37477.5321","37 HS578T GSK 1 uM":"127305.2690","33 HS578T DMM 5 mM":"579477.2748","36 HS578T DMM 5 mM":"356189.1598","35 HS578T Combination":"656260.5011","38 HS578T Combination":"360390.0240","16 MCF7 GSK 1 uM":"36445.0282","19 MCF7 GSK 1 uM":"15947.6988","15 MCF7 DMM 5 mM":"291084.9554","18 MCF7 DMM 5 mM":"652269.7869","17 MCF7 Combination":"236477.6247","20 MCF7 Combination":"154123.7798","28 MDA-MB-231 GSK 1 uM":"108566.5519","31 MDA-MB-231 GSK 1 uM":"46910.1929","27 MDA-MB-231 DMM 5 mM":"667276.3119","30 MDA-MB-231 DMM 5 mM":"1049467.9100","29 MDA-MB-231 Combination":"866085.2245","32 MDA-MB-231 Combination":"603599.7556","04 MDA-MB-468 GSK 1 uM":"1771.4851","07 MDA-MB-468 GSK 1 uM":"280.5911","03 MDA-MB-468 DMM 5 mM":"5649.8724","06 MDA-MB-468 DMM 5 mM":"1689.1922","05 MDA-MB-468 Combination":"180.0965","08 MDA-MB-468 Combination":"2931.2232","01 Blank":"553.0254","46 Blank":"414.3421","02 DMEM/F12 no adds":"1484.1171","45 DMEM/F12 no adds":"9839.3942","10 SUM159PT GSK 1 uM":"70167.2982","13 SUM159PT GSK 1 uM":"34124.5975","09 SUM159PT DMM 5 mM":"589958.3602","12 SUM159PT DMM 5 mM":"387932.6669","11 SUM159PT Combination":"563145.3894","14 SUM159PT Combination":"592030.1299"},{"Metabolite":"Doxycycline 321","40 CAL120 GSK 1 uM":"217.9390","43 CAL120 GSK 1 uM":"630.8190","39 CAL120 DMM 5 mM":"214.0533","42 CAL120 DMM 5 mM":"447.6071","41 CAL120 Combination":"905.8433","44 CAL120 Combination":"226.2852","22 HCC1806 GSK 1 uM":"678.7182","25 HCC1806 GSK 1 uM":"450.7891","21 HCC1806 DMM 5 mM":"425.2479","24 HCC1806 DMM 5 mM":"847.8755","23 HCC1806 Combination":"223.3520","26 HCC1806 Combination":"222.9622","34 HS578T GSK 1 uM":"","37 HS578T GSK 1 uM":"912.3453","33 HS578T DMM 5 mM":"447.0774","36 HS578T DMM 5 mM":"","35 HS578T Combination":"","38 HS578T Combination":"450.3017","16 MCF7 GSK 1 uM":"434.5840","19 MCF7 GSK 1 uM":"634.5368","15 MCF7 DMM 5 mM":"441.9799","18 MCF7 DMM 5 mM":"648.9418","17 MCF7 Combination":"445.3417","20 MCF7 Combination":"627.2452","28 MDA-MB-231 GSK 1 uM":"218.0779","31 MDA-MB-231 GSK 1 uM":"223.4937","27 MDA-MB-231 DMM 5 mM":"227.3588","30 MDA-MB-231 DMM 5 mM":"678.2764","29 MDA-MB-231 Combination":"462.1499","32 MDA-MB-231 Combination":"444.4423","04 MDA-MB-468 GSK 1 uM":"450.0433","07 MDA-MB-468 GSK 1 uM":"","03 MDA-MB-468 DMM 5 mM":"445.9943","06 MDA-MB-468 DMM 5 mM":"","05 MDA-MB-468 Combination":"669.1307","08 MDA-MB-468 Combination":"1480.7113","01 Blank":"218.1536","46 Blank":"439.2575","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"219.7609","10 SUM159PT GSK 1 uM":"","13 SUM159PT GSK 1 uM":"679.6680","09 SUM159PT DMM 5 mM":"","12 SUM159PT DMM 5 mM":"","11 SUM159PT Combination":"223.6611","14 SUM159PT Combination":""},{"Metabolite":"Ethanolamine 29","40 CAL120 GSK 1 uM":"19513.5036","43 CAL120 GSK 1 uM":"19940.1499","39 CAL120 DMM 5 mM":"19047.2916","42 CAL120 DMM 5 mM":"17674.2853","41 CAL120 Combination":"18910.9218","44 CAL120 Combination":"15583.3559","22 HCC1806 GSK 1 uM":"14059.5118","25 HCC1806 GSK 1 uM":"15671.9381","21 HCC1806 DMM 5 mM":"11978.5979","24 HCC1806 DMM 5 mM":"13865.1365","23 HCC1806 Combination":"14371.8055","26 HCC1806 Combination":"14453.9199","34 HS578T GSK 1 uM":"22318.8701","37 HS578T GSK 1 uM":"20500.6555","33 HS578T DMM 5 mM":"19964.3789","36 HS578T DMM 5 mM":"21225.0173","35 HS578T Combination":"19969.0867","38 HS578T Combination":"4536.0005","16 MCF7 GSK 1 uM":"10546.7315","19 MCF7 GSK 1 uM":"9117.5590","15 MCF7 DMM 5 mM":"6608.8249","18 MCF7 DMM 5 mM":"5858.0951","17 MCF7 Combination":"7783.0577","20 MCF7 Combination":"8873.4001","28 MDA-MB-231 GSK 1 uM":"12042.2144","31 MDA-MB-231 GSK 1 uM":"13548.1825","27 MDA-MB-231 DMM 5 mM":"11338.4770","30 MDA-MB-231 DMM 5 mM":"11651.2640","29 MDA-MB-231 Combination":"11688.4077","32 MDA-MB-231 Combination":"17694.2090","04 MDA-MB-468 GSK 1 uM":"6042.7323","07 MDA-MB-468 GSK 1 uM":"5263.0636","03 MDA-MB-468 DMM 5 mM":"4845.3071","06 MDA-MB-468 DMM 5 mM":"4510.7459","05 MDA-MB-468 Combination":"4758.7696","08 MDA-MB-468 Combination":"3403.8882","01 Blank":"554.4477","46 Blank":"1500.7846","02 DMEM/F12 no adds":"245.0137","45 DMEM/F12 no adds":"961.1520","10 SUM159PT GSK 1 uM":"13996.0832","13 SUM159PT GSK 1 uM":"14811.5776","09 SUM159PT DMM 5 mM":"12485.3738","12 SUM159PT DMM 5 mM":"13376.7121","11 SUM159PT Combination":"15936.0423","14 SUM159PT Combination":"14544.6591"},{"Metabolite":"Ethanolamine 44","40 CAL120 GSK 1 uM":"424180.5637","43 CAL120 GSK 1 uM":"489485.1242","39 CAL120 DMM 5 mM":"426048.5620","42 CAL120 DMM 5 mM":"430768.7703","41 CAL120 Combination":"426512.4392","44 CAL120 Combination":"361173.4588","22 HCC1806 GSK 1 uM":"332627.0828","25 HCC1806 GSK 1 uM":"313080.0167","21 HCC1806 DMM 5 mM":"301090.2048","24 HCC1806 DMM 5 mM":"326062.4020","23 HCC1806 Combination":"349425.7999","26 HCC1806 Combination":"345271.9255","34 HS578T GSK 1 uM":"533398.1717","37 HS578T GSK 1 uM":"461506.1612","33 HS578T DMM 5 mM":"433108.4893","36 HS578T DMM 5 mM":"540020.5105","35 HS578T Combination":"464477.9802","38 HS578T Combination":"103765.6002","16 MCF7 GSK 1 uM":"248086.1894","19 MCF7 GSK 1 uM":"218287.4910","15 MCF7 DMM 5 mM":"145006.3997","18 MCF7 DMM 5 mM":"155097.2491","17 MCF7 Combination":"186080.9396","20 MCF7 Combination":"196229.7055","28 MDA-MB-231 GSK 1 uM":"273017.3402","31 MDA-MB-231 GSK 1 uM":"307075.8718","27 MDA-MB-231 DMM 5 mM":"276405.5433","30 MDA-MB-231 DMM 5 mM":"254728.8883","29 MDA-MB-231 Combination":"283144.0803","32 MDA-MB-231 Combination":"417317.6913","04 MDA-MB-468 GSK 1 uM":"132324.6274","07 MDA-MB-468 GSK 1 uM":"124498.5557","03 MDA-MB-468 DMM 5 mM":"126965.2323","06 MDA-MB-468 DMM 5 mM":"110097.6272","05 MDA-MB-468 Combination":"101105.2631","08 MDA-MB-468 Combination":"107187.2610","01 Blank":"25862.8793","46 Blank":"42000.5057","02 DMEM/F12 no adds":"7396.8748","45 DMEM/F12 no adds":"5975.2311","10 SUM159PT GSK 1 uM":"329864.6439","13 SUM159PT GSK 1 uM":"340835.1206","09 SUM159PT DMM 5 mM":"292559.1514","12 SUM159PT DMM 5 mM":"311196.8363","11 SUM159PT Combination":"359951.3607","14 SUM159PT Combination":"358577.0289"},{"Metabolite":"Fasnall 218","40 CAL120 GSK 1 uM":"783.4927","43 CAL120 GSK 1 uM":"214.0961","39 CAL120 DMM 5 mM":"1005.7281","42 CAL120 DMM 5 mM":"1407.9826","41 CAL120 Combination":"371.9027","44 CAL120 Combination":"1239.6920","22 HCC1806 GSK 1 uM":"1446.7081","25 HCC1806 GSK 1 uM":"642.6004","21 HCC1806 DMM 5 mM":"1022.1802","24 HCC1806 DMM 5 mM":"1201.8290","23 HCC1806 Combination":"421.3115","26 HCC1806 Combination":"406.3940","34 HS578T GSK 1 uM":"626.8468","37 HS578T GSK 1 uM":"1281.6564","33 HS578T DMM 5 mM":"2181.2852","36 HS578T DMM 5 mM":"891.0621","35 HS578T Combination":"806.4720","38 HS578T Combination":"1052.8012","16 MCF7 GSK 1 uM":"649.1245","19 MCF7 GSK 1 uM":"1287.8837","15 MCF7 DMM 5 mM":"806.4457","18 MCF7 DMM 5 mM":"862.6792","17 MCF7 Combination":"806.0109","20 MCF7 Combination":"598.0329","28 MDA-MB-231 GSK 1 uM":"649.9103","31 MDA-MB-231 GSK 1 uM":"980.3004","27 MDA-MB-231 DMM 5 mM":"1281.4165","30 MDA-MB-231 DMM 5 mM":"741.2449","29 MDA-MB-231 Combination":"796.3918","32 MDA-MB-231 Combination":"619.7055","04 MDA-MB-468 GSK 1 uM":"1768.8997","07 MDA-MB-468 GSK 1 uM":"1695.9852","03 MDA-MB-468 DMM 5 mM":"2016.9395","06 MDA-MB-468 DMM 5 mM":"863.0661","05 MDA-MB-468 Combination":"1492.9249","08 MDA-MB-468 Combination":"1258.4226","01 Blank":"2764.4436","46 Blank":"771.0710","02 DMEM/F12 no 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MCF7 DMM 5 mM":"124388.8166","18 MCF7 DMM 5 mM":"203281.0463","17 MCF7 Combination":"69286.8403","20 MCF7 Combination":"40377.4911","28 MDA-MB-231 GSK 1 uM":"115413.3169","31 MDA-MB-231 GSK 1 uM":"101149.4891","27 MDA-MB-231 DMM 5 mM":"117318.1502","30 MDA-MB-231 DMM 5 mM":"137641.9409","29 MDA-MB-231 Combination":"81981.6553","32 MDA-MB-231 Combination":"72270.5865","04 MDA-MB-468 GSK 1 uM":"325480.2018","07 MDA-MB-468 GSK 1 uM":"415709.6963","03 MDA-MB-468 DMM 5 mM":"442303.3358","06 MDA-MB-468 DMM 5 mM":"356902.6431","05 MDA-MB-468 Combination":"200507.7306","08 MDA-MB-468 Combination":"367028.3981","01 Blank":"3510.6370","46 Blank":"6799.7819","02 DMEM/F12 no adds":"2980053.6680","45 DMEM/F12 no adds":"3048294.2920","10 SUM159PT GSK 1 uM":"67959.6165","13 SUM159PT GSK 1 uM":"50714.1637","09 SUM159PT DMM 5 mM":"67976.1812","12 SUM159PT DMM 5 mM":"46171.7253","11 SUM159PT Combination":"42176.7281","14 SUM159PT Combination":"58725.3779"},{"Metabolite":"Formyl-CoA 428","40 CAL120 GSK 1 uM":"583.0583","43 CAL120 GSK 1 uM":"664.0931","39 CAL120 DMM 5 mM":"1006.9227","42 CAL120 DMM 5 mM":"704.1612","41 CAL120 Combination":"599.8440","44 CAL120 Combination":"542.5310","22 HCC1806 GSK 1 uM":"2045.0658","25 HCC1806 GSK 1 uM":"1510.3552","21 HCC1806 DMM 5 mM":"4668.0103","24 HCC1806 DMM 5 mM":"2768.3494","23 HCC1806 Combination":"1886.7737","26 HCC1806 Combination":"2493.9357","34 HS578T GSK 1 uM":"966.2428","37 HS578T GSK 1 uM":"267.2565","33 HS578T DMM 5 mM":"137.3576","36 HS578T DMM 5 mM":"264.4177","35 HS578T Combination":"801.4090","38 HS578T Combination":"400.6825","16 MCF7 GSK 1 uM":"721.0180","19 MCF7 GSK 1 uM":"729.6990","15 MCF7 DMM 5 mM":"273.2468","18 MCF7 DMM 5 mM":"641.2472","17 MCF7 Combination":"719.7286","20 MCF7 Combination":"135.4203","28 MDA-MB-231 GSK 1 uM":"533.2108","31 MDA-MB-231 GSK 1 uM":"674.0136","27 MDA-MB-231 DMM 5 mM":"494.6078","30 MDA-MB-231 DMM 5 mM":"914.7056","29 MDA-MB-231 Combination":"246.6351","32 MDA-MB-231 Combination":"166.8829","04 MDA-MB-468 GSK 1 uM":"945.1174","07 MDA-MB-468 GSK 1 uM":"1100.9514","03 MDA-MB-468 DMM 5 mM":"1217.6943","06 MDA-MB-468 DMM 5 mM":"445.5035","05 MDA-MB-468 Combination":"1478.5529","08 MDA-MB-468 Combination":"2147.2751","01 Blank":"315.5944","46 Blank":"240.8797","02 DMEM/F12 no adds":"123.8373","45 DMEM/F12 no adds":"244.6399","10 SUM159PT GSK 1 uM":"922.6537","13 SUM159PT GSK 1 uM":"2929.9394","09 SUM159PT DMM 5 mM":"2176.4728","12 SUM159PT DMM 5 mM":"2850.7120","11 SUM159PT Combination":"1160.1195","14 SUM159PT Combination":"2116.6951"},{"Metabolite":"GABA 87","40 CAL120 GSK 1 uM":"1094119.6290","43 CAL120 GSK 1 uM":"1090972.5690","39 CAL120 DMM 5 mM":"715308.1778","42 CAL120 DMM 5 mM":"717604.1734","41 CAL120 Combination":"631911.7287","44 CAL120 Combination":"722718.3577","22 HCC1806 GSK 1 uM":"23621442.6500","25 HCC1806 GSK 1 uM":"24825320.0300","21 HCC1806 DMM 5 mM":"11509259.0200","24 HCC1806 DMM 5 mM":"12211629.6300","23 HCC1806 Combination":"11861818.3300","26 HCC1806 Combination":"12592437.6600","34 HS578T GSK 1 uM":"3493472.1650","37 HS578T GSK 1 uM":"3875097.5050","33 HS578T DMM 5 mM":"1183628.9520","36 HS578T DMM 5 mM":"1099570.8430","35 HS578T Combination":"1530633.1540","38 HS578T Combination":"1151363.1040","16 MCF7 GSK 1 uM":"1308166.7650","19 MCF7 GSK 1 uM":"1654346.1850","15 MCF7 DMM 5 mM":"1293473.2350","18 MCF7 DMM 5 mM":"1202611.2500","17 MCF7 Combination":"1083653.8260","20 MCF7 Combination":"883888.4644","28 MDA-MB-231 GSK 1 uM":"2508370.2560","31 MDA-MB-231 GSK 1 uM":"2689531.5360","27 MDA-MB-231 DMM 5 mM":"2295888.7330","30 MDA-MB-231 DMM 5 mM":"2329285.5630","29 MDA-MB-231 Combination":"2189407.3100","32 MDA-MB-231 Combination":"2394857.1570","04 MDA-MB-468 GSK 1 uM":"4450497.0680","07 MDA-MB-468 GSK 1 uM":"4661075.7780","03 MDA-MB-468 DMM 5 mM":"5672230.7460","06 MDA-MB-468 DMM 5 mM":"5046723.1110","05 MDA-MB-468 Combination":"4821028.6910","08 MDA-MB-468 Combination":"4855735.3680","01 Blank":"4450.8467","46 Blank":"6166.3989","02 DMEM/F12 no adds":"2962.5323","45 DMEM/F12 no adds":"5345.2967","10 SUM159PT GSK 1 uM":"2627542.7850","13 SUM159PT GSK 1 uM":"3618782.4210","09 SUM159PT DMM 5 mM":"1983982.4350","12 SUM159PT DMM 5 mM":"2067349.5600","11 SUM159PT Combination":"2004584.2520","14 SUM159PT Combination":"2205657.6940"},{"Metabolite":"Glutamine 130","40 CAL120 GSK 1 uM":"6219.3477","43 CAL120 GSK 1 uM":"41070.7673","39 CAL120 DMM 5 mM":"41154.0664","42 CAL120 DMM 5 mM":"12101.5953","41 CAL120 Combination":"12516.7329","44 CAL120 Combination":"10327.9322","22 HCC1806 GSK 1 uM":"32808.8946","25 HCC1806 GSK 1 uM":"582.7063","21 HCC1806 DMM 5 mM":"12894.7841","24 HCC1806 DMM 5 mM":"49532.0905","23 HCC1806 Combination":"10951.9235","26 HCC1806 Combination":"10180.2552","34 HS578T GSK 1 uM":"62072.4155","37 HS578T GSK 1 uM":"37294.4390","33 HS578T DMM 5 mM":"24707.8612","36 HS578T DMM 5 mM":"49445.1497","35 HS578T Combination":"15807.3112","38 HS578T Combination":"50848.5823","16 MCF7 GSK 1 uM":"46834.2794","19 MCF7 GSK 1 uM":"19100.5472","15 MCF7 DMM 5 mM":"20938.7225","18 MCF7 DMM 5 mM":"28999.1584","17 MCF7 Combination":"58768.6259","20 MCF7 Combination":"28204.5888","28 MDA-MB-231 GSK 1 uM":"1118.9922","31 MDA-MB-231 GSK 1 uM":"32030.1008","27 MDA-MB-231 DMM 5 mM":"1448.4253","30 MDA-MB-231 DMM 5 mM":"726.4568","29 MDA-MB-231 Combination":"21440.3161","32 MDA-MB-231 Combination":"21488.9908","04 MDA-MB-468 GSK 1 uM":"3660.3300","07 MDA-MB-468 GSK 1 uM":"2749.6015","03 MDA-MB-468 DMM 5 mM":"15827.1886","06 MDA-MB-468 DMM 5 mM":"3472.7480","05 MDA-MB-468 Combination":"21942.3332","08 MDA-MB-468 Combination":"6312.0460","01 Blank":"740.1797","46 Blank":"412.9096","02 DMEM/F12 no adds":"219579.3417","45 DMEM/F12 no adds":"228357.8343","10 SUM159PT GSK 1 uM":"18914.6025","13 SUM159PT GSK 1 uM":"9357.7430","09 SUM159PT DMM 5 mM":"52580.4598","12 SUM159PT DMM 5 mM":"25763.1846","11 SUM159PT Combination":"52923.6020","14 SUM159PT Combination":"58067.4132"},{"Metabolite":"Glutamine 84","40 CAL120 GSK 1 uM":"4804702.9670","43 CAL120 GSK 1 uM":"25958236.2300","39 CAL120 DMM 5 mM":"27800079.9100","42 CAL120 DMM 5 mM":"8442113.5550","41 CAL120 Combination":"7455459.2200","44 CAL120 Combination":"7686977.4180","22 HCC1806 GSK 1 uM":"21623075.2800","25 HCC1806 GSK 1 uM":"358904.9485","21 HCC1806 DMM 5 mM":"13112706.6700","24 HCC1806 DMM 5 mM":"35409938.3000","23 HCC1806 Combination":"9391654.1970","26 HCC1806 Combination":"9368484.8180","34 HS578T GSK 1 uM":"38177649.7800","37 HS578T GSK 1 uM":"23407436.4800","33 HS578T DMM 5 mM":"17226445.5800","36 HS578T DMM 5 mM":"32937563.2300","35 HS578T Combination":"18422663.2200","38 HS578T Combination":"32539550.4200","16 MCF7 GSK 1 uM":"22199233.7500","19 MCF7 GSK 1 uM":"14631327.1700","15 MCF7 DMM 5 mM":"12279307.2900","18 MCF7 DMM 5 mM":"17670317.5900","17 MCF7 Combination":"34511375.5300","20 MCF7 Combination":"16168112.9600","28 MDA-MB-231 GSK 1 uM":"208265.4529","31 MDA-MB-231 GSK 1 uM":"17584907.3800","27 MDA-MB-231 DMM 5 mM":"210268.3847","30 MDA-MB-231 DMM 5 mM":"188855.7712","29 MDA-MB-231 Combination":"16434932.0200","32 MDA-MB-231 Combination":"15855392.2000","04 MDA-MB-468 GSK 1 uM":"1645958.2210","07 MDA-MB-468 GSK 1 uM":"1344146.5370","03 MDA-MB-468 DMM 5 mM":"11449597.6800","06 MDA-MB-468 DMM 5 mM":"1679287.0170","05 MDA-MB-468 Combination":"16758922.4200","08 MDA-MB-468 Combination":"2921458.1440","01 Blank":"11165.0196","46 Blank":"20071.9995","02 DMEM/F12 no adds":"117370980.9000","45 DMEM/F12 no adds":"130550353.2000","10 SUM159PT GSK 1 uM":"10297350.5000","13 SUM159PT GSK 1 uM":"6808320.4730","09 SUM159PT DMM 5 mM":"33232824.8000","12 SUM159PT DMM 5 mM":"14469009.9200","11 SUM159PT Combination":"31850479.0000","14 SUM159PT Combination":"36610161.0400"},{"Metabolite":"Glycine PAR POS","40 CAL120 GSK 1 uM":"6244857.5600","43 CAL120 GSK 1 uM":"6688130.7080","39 CAL120 DMM 5 mM":"5843472.6670","42 CAL120 DMM 5 mM":"5459490.3920","41 CAL120 Combination":"5060689.9400","44 CAL120 Combination":"5600412.3360","22 HCC1806 GSK 1 uM":"8496448.1970","25 HCC1806 GSK 1 uM":"7874156.7080","21 HCC1806 DMM 5 mM":"13376618.3700","24 HCC1806 DMM 5 mM":"14197073.4600","23 HCC1806 Combination":"15143037.6900","26 HCC1806 Combination":"14578068.0200","34 HS578T GSK 1 uM":"6120155.2950","37 HS578T GSK 1 uM":"6307714.7460","33 HS578T DMM 5 mM":"5125111.1570","36 HS578T DMM 5 mM":"4972403.3280","35 HS578T Combination":"5980339.5680","38 HS578T Combination":"5263412.2740","16 MCF7 GSK 1 uM":"4445994.1740","19 MCF7 GSK 1 uM":"5951842.7720","15 MCF7 DMM 5 mM":"6126499.3250","18 MCF7 DMM 5 mM":"6064788.2480","17 MCF7 Combination":"6657707.0730","20 MCF7 Combination":"4168769.3300","28 MDA-MB-231 GSK 1 uM":"3968684.1480","31 MDA-MB-231 GSK 1 uM":"4409839.0860","27 MDA-MB-231 DMM 5 mM":"3333803.4370","30 MDA-MB-231 DMM 5 mM":"3173674.0740","29 MDA-MB-231 Combination":"3254856.6280","32 MDA-MB-231 Combination":"3333321.6480","04 MDA-MB-468 GSK 1 uM":"33423150.8600","07 MDA-MB-468 GSK 1 uM":"36014636.9700","03 MDA-MB-468 DMM 5 mM":"30117608.8800","06 MDA-MB-468 DMM 5 mM":"28944590.1100","05 MDA-MB-468 Combination":"30334042.7900","08 MDA-MB-468 Combination":"30429341.7000","01 Blank":"29046.1032","46 Blank":"338356.7121","02 DMEM/F12 no adds":"4314426.8970","45 DMEM/F12 no adds":"6253000.4550","10 SUM159PT GSK 1 uM":"8212251.0250","13 SUM159PT GSK 1 uM":"9852036.0160","09 SUM159PT DMM 5 mM":"6716096.9600","12 SUM159PT DMM 5 mM":"6234658.6730","11 SUM159PT Combination":"6234491.7920","14 SUM159PT Combination":"6859776.4860"},{"Metabolite":"GSH 290","40 CAL120 GSK 1 uM":"4009476.0810","43 CAL120 GSK 1 uM":"3979887.9420","39 CAL120 DMM 5 mM":"4032556.3540","42 CAL120 DMM 5 mM":"3884649.6590","41 CAL120 Combination":"3999860.6270","44 CAL120 Combination":"4095281.3160","22 HCC1806 GSK 1 uM":"12274926.8200","25 HCC1806 GSK 1 uM":"12391087.6500","21 HCC1806 DMM 5 mM":"8186043.2530","24 HCC1806 DMM 5 mM":"8648825.8530","23 HCC1806 Combination":"8411534.6450","26 HCC1806 Combination":"8681703.0190","34 HS578T GSK 1 uM":"4246489.2260","37 HS578T GSK 1 uM":"4251899.8410","33 HS578T DMM 5 mM":"3805883.9820","36 HS578T DMM 5 mM":"3897505.4920","35 HS578T Combination":"4496436.0120","38 HS578T Combination":"3776302.7890","16 MCF7 GSK 1 uM":"5238933.6860","19 MCF7 GSK 1 uM":"6551114.2840","15 MCF7 DMM 5 mM":"6426823.4430","18 MCF7 DMM 5 mM":"6161052.3830","17 MCF7 Combination":"6033769.5350","20 MCF7 Combination":"3948510.5110","28 MDA-MB-231 GSK 1 uM":"6145439.6450","31 MDA-MB-231 GSK 1 uM":"6685776.8860","27 MDA-MB-231 DMM 5 mM":"6081345.9630","30 MDA-MB-231 DMM 5 mM":"6546989.1020","29 MDA-MB-231 Combination":"6181307.6180","32 MDA-MB-231 Combination":"6586605.5700","04 MDA-MB-468 GSK 1 uM":"7559229.1980","07 MDA-MB-468 GSK 1 uM":"8246773.0860","03 MDA-MB-468 DMM 5 mM":"8535240.7450","06 MDA-MB-468 DMM 5 mM":"8379557.9340","05 MDA-MB-468 Combination":"9035276.1520","08 MDA-MB-468 Combination":"9063988.9340","01 Blank":"8655.0531","46 Blank":"10780.4439","02 DMEM/F12 no adds":"94337.9130","45 DMEM/F12 no adds":"182180.2830","10 SUM159PT GSK 1 uM":"5219409.0020","13 SUM159PT GSK 1 uM":"6305721.0550","09 SUM159PT DMM 5 mM":"7379488.1990","12 SUM159PT DMM 5 mM":"7896819.6160","11 SUM159PT Combination":"6989586.6030","14 SUM159PT Combination":"7776106.2700"},{"Metabolite":"GSH 76","40 CAL120 GSK 1 uM":"80719184.9800","43 CAL120 GSK 1 uM":"79018317.3500","39 CAL120 DMM 5 mM":"76164758.5800","42 CAL120 DMM 5 mM":"77443707.9500","41 CAL120 Combination":"77372296.3800","44 CAL120 Combination":"77792585.8100","22 HCC1806 GSK 1 uM":"178579884.7000","25 HCC1806 GSK 1 uM":"180460244.5000","21 HCC1806 DMM 5 mM":"133638841.4000","24 HCC1806 DMM 5 mM":"139434557.5000","23 HCC1806 Combination":"139927615.3000","26 HCC1806 Combination":"142222972.8000","34 HS578T GSK 1 uM":"81176259.9600","37 HS578T GSK 1 uM":"81546564.0700","33 HS578T DMM 5 mM":"72036067.1500","36 HS578T DMM 5 mM":"74596668.8600","35 HS578T Combination":"85047081.8500","38 HS578T Combination":"74460413.5100","16 MCF7 GSK 1 uM":"95590413.3400","19 MCF7 GSK 1 uM":"114123853.2000","15 MCF7 DMM 5 mM":"111739777.0000","18 MCF7 DMM 5 mM":"110940326.7000","17 MCF7 Combination":"107527372.2000","20 MCF7 Combination":"76810017.5300","28 MDA-MB-231 GSK 1 uM":"109287834.7000","31 MDA-MB-231 GSK 1 uM":"120193375.7000","27 MDA-MB-231 DMM 5 mM":"109011072.6000","30 MDA-MB-231 DMM 5 mM":"113068380.3000","29 MDA-MB-231 Combination":"107416217.1000","32 MDA-MB-231 Combination":"116164070.5000","04 MDA-MB-468 GSK 1 uM":"125685049.9000","07 MDA-MB-468 GSK 1 uM":"136795554.7000","03 MDA-MB-468 DMM 5 mM":"137530832.3000","06 MDA-MB-468 DMM 5 mM":"138934307.8000","05 MDA-MB-468 Combination":"145119352.8000","08 MDA-MB-468 Combination":"142089615.1000","01 Blank":"12461.2697","46 Blank":"85982.4089","02 DMEM/F12 no adds":"30937.6300","45 DMEM/F12 no adds":"524148.4590","10 SUM159PT GSK 1 uM":"94502941.1000","13 SUM159PT GSK 1 uM":"111951273.9000","09 SUM159PT DMM 5 mM":"120594804.4000","12 SUM159PT DMM 5 mM":"130842188.7000","11 SUM159PT Combination":"120729433.5000","14 SUM159PT Combination":"131658533.2000"},{"Metabolite":"GSK2194069 344","40 CAL120 GSK 1 uM":"2882888.7210","43 CAL120 GSK 1 uM":"3625765.9300","39 CAL120 DMM 5 mM":"438.5489","42 CAL120 DMM 5 mM":"200.7956","41 CAL120 Combination":"2913793.5130","44 CAL120 Combination":"2648112.8950","22 HCC1806 GSK 1 uM":"5174709.6110","25 HCC1806 GSK 1 uM":"6034982.8120","21 HCC1806 DMM 5 mM":"478.0881","24 HCC1806 DMM 5 mM":"806.4404","23 HCC1806 Combination":"3979598.2820","26 HCC1806 Combination":"5289767.1470","34 HS578T GSK 1 uM":"2155349.0220","37 HS578T GSK 1 uM":"1831381.0010","33 HS578T DMM 5 mM":"322.3606","36 HS578T DMM 5 mM":"201.6113","35 HS578T Combination":"1913080.3510","38 HS578T Combination":"1487025.1350","16 MCF7 GSK 1 uM":"3791271.8840","19 MCF7 GSK 1 uM":"4343913.8360","15 MCF7 DMM 5 mM":"319.6031","18 MCF7 DMM 5 mM":"487.0022","17 MCF7 Combination":"3494204.3530","20 MCF7 Combination":"2947147.9060","28 MDA-MB-231 GSK 1 uM":"2004973.0090","31 MDA-MB-231 GSK 1 uM":"2091928.0610","27 MDA-MB-231 DMM 5 mM":"585.6989","30 MDA-MB-231 DMM 5 mM":"434.8263","29 MDA-MB-231 Combination":"2161419.3240","32 MDA-MB-231 Combination":"2364155.1750","04 MDA-MB-468 GSK 1 uM":"5796095.6750","07 MDA-MB-468 GSK 1 uM":"6057241.9240","03 MDA-MB-468 DMM 5 mM":"213.8963","06 MDA-MB-468 DMM 5 mM":"208.5296","05 MDA-MB-468 Combination":"6111796.3560","08 MDA-MB-468 Combination":"7901759.5210","01 Blank":"386.5619","46 Blank":"317.7812","02 DMEM/F12 no adds":"514.3562","45 DMEM/F12 no adds":"202.9845","10 SUM159PT GSK 1 uM":"2921483.4440","13 SUM159PT GSK 1 uM":"4237480.7530","09 SUM159PT DMM 5 mM":"315.7913","12 SUM159PT DMM 5 mM":"321.3878","11 SUM159PT Combination":"4045305.3440","14 SUM159PT Combination":"4387400.1360"},{"Metabolite":"Guanine 135","40 CAL120 GSK 1 uM":"1354506.7900","43 CAL120 GSK 1 uM":"344744.0225","39 CAL120 DMM 5 mM":"318432.7380","42 CAL120 DMM 5 mM":"1532341.9490","41 CAL120 Combination":"1422061.1200","44 CAL120 Combination":"1558069.5390","22 HCC1806 GSK 1 uM":"121545.8031","25 HCC1806 GSK 1 uM":"2266908.8450","21 HCC1806 DMM 5 mM":"2067037.9640","24 HCC1806 DMM 5 mM":"170474.8509","23 HCC1806 Combination":"2315516.8120","26 HCC1806 Combination":"2462033.7540","34 HS578T GSK 1 uM":"309542.8318","37 HS578T GSK 1 uM":"451546.5267","33 HS578T DMM 5 mM":"409840.4264","36 HS578T DMM 5 mM":"248816.6775","35 HS578T Combination":"660551.8244","38 HS578T Combination":"100878.5841","16 MCF7 GSK 1 uM":"302226.4827","19 MCF7 GSK 1 uM":"897572.7561","15 MCF7 DMM 5 mM":"1056187.6370","18 MCF7 DMM 5 mM":"633599.7551","17 MCF7 Combination":"521373.0950","20 MCF7 Combination":"477438.6172","28 MDA-MB-231 GSK 1 uM":"962906.5651","31 MDA-MB-231 GSK 1 uM":"104288.8340","27 MDA-MB-231 DMM 5 mM":"991920.8635","30 MDA-MB-231 DMM 5 mM":"756197.6105","29 MDA-MB-231 Combination":"115551.0225","32 MDA-MB-231 Combination":"186432.6229","04 MDA-MB-468 GSK 1 uM":"1029085.5710","07 MDA-MB-468 GSK 1 uM":"1145479.6340","03 MDA-MB-468 DMM 5 mM":"76059.4175","06 MDA-MB-468 DMM 5 mM":"1040664.4780","05 MDA-MB-468 Combination":"63789.5285","08 MDA-MB-468 Combination":"1372983.7640","01 Blank":"1125.1646","46 Blank":"180.7813","02 DMEM/F12 no adds":"5931.6731","45 DMEM/F12 no adds":"16981.5033","10 SUM159PT GSK 1 uM":"1633332.9510","13 SUM159PT GSK 1 uM":"2015841.1310","09 SUM159PT DMM 5 mM":"164945.4289","12 SUM159PT DMM 5 mM":"1559881.2230","11 SUM159PT Combination":"277752.6057","14 SUM159PT Combination":"236845.7691"},{"Metabolite":"Guanosine 152","40 CAL120 GSK 1 uM":"5729683.2220","43 CAL120 GSK 1 uM":"6561251.5530","39 CAL120 DMM 5 mM":"2886785.3280","42 CAL120 DMM 5 mM":"3853797.1280","41 CAL120 Combination":"3073184.3400","44 CAL120 Combination":"4920236.8420","22 HCC1806 GSK 1 uM":"61965.4930","25 HCC1806 GSK 1 uM":"70518.8466","21 HCC1806 DMM 5 mM":"67549.6313","24 HCC1806 DMM 5 mM":"52133.4364","23 HCC1806 Combination":"67341.4671","26 HCC1806 Combination":"76752.4335","34 HS578T GSK 1 uM":"271693.5062","37 HS578T GSK 1 uM":"201853.5933","33 HS578T DMM 5 mM":"143939.7322","36 HS578T DMM 5 mM":"302417.0224","35 HS578T Combination":"169129.5626","38 HS578T Combination":"451555.8378","16 MCF7 GSK 1 uM":"113105.9924","19 MCF7 GSK 1 uM":"128346.5231","15 MCF7 DMM 5 mM":"113117.5633","18 MCF7 DMM 5 mM":"86359.6232","17 MCF7 Combination":"102811.4146","20 MCF7 Combination":"84534.2845","28 MDA-MB-231 GSK 1 uM":"764172.4732","31 MDA-MB-231 GSK 1 uM":"742079.7343","27 MDA-MB-231 DMM 5 mM":"353225.8681","30 MDA-MB-231 DMM 5 mM":"412631.5161","29 MDA-MB-231 Combination":"583527.7340","32 MDA-MB-231 Combination":"803512.4973","04 MDA-MB-468 GSK 1 uM":"512849.0006","07 MDA-MB-468 GSK 1 uM":"459592.0424","03 MDA-MB-468 DMM 5 mM":"611176.9639","06 MDA-MB-468 DMM 5 mM":"747009.1794","05 MDA-MB-468 Combination":"620808.7491","08 MDA-MB-468 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Combination":"6483515.2570","38 HS578T Combination":"","16 MCF7 GSK 1 uM":"6408677.0650","19 MCF7 GSK 1 uM":"","15 MCF7 DMM 5 mM":"","18 MCF7 DMM 5 mM":"","17 MCF7 Combination":"294690.9221","20 MCF7 Combination":"4378065.5170","28 MDA-MB-231 GSK 1 uM":"4170994.5900","31 MDA-MB-231 GSK 1 uM":"4760190.8190","27 MDA-MB-231 DMM 5 mM":"3941821.1760","30 MDA-MB-231 DMM 5 mM":"4590145.8190","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"6075561.6290","04 MDA-MB-468 GSK 1 uM":"293123.4154","07 MDA-MB-468 GSK 1 uM":"334738.3870","03 MDA-MB-468 DMM 5 mM":"224649.9424","06 MDA-MB-468 DMM 5 mM":"","05 MDA-MB-468 Combination":"","08 MDA-MB-468 Combination":"313960.3940","01 Blank":"19651.3675","46 Blank":"14735.4218","02 DMEM/F12 no adds":"26274868.4000","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"4371211.3810","13 SUM159PT GSK 1 uM":"","09 SUM159PT DMM 5 mM":"","12 SUM159PT DMM 5 mM":"4281293.8150","11 SUM159PT Combination":"4445862.9330","14 SUM159PT Combination":""},{"Metabolite":"Histidine 83","40 CAL120 GSK 1 uM":"216508.1850","43 CAL120 GSK 1 uM":"187248.9002","39 CAL120 DMM 5 mM":"293231.4889","42 CAL120 DMM 5 mM":"242955.7080","41 CAL120 Combination":"160318.4957","44 CAL120 Combination":"231887.1686","22 HCC1806 GSK 1 uM":"653166.0663","25 HCC1806 GSK 1 uM":"580282.3089","21 HCC1806 DMM 5 mM":"592457.1778","24 HCC1806 DMM 5 mM":"1000851.1690","23 HCC1806 Combination":"605222.0120","26 HCC1806 Combination":"618081.6670","34 HS578T GSK 1 uM":"287546.3560","37 HS578T GSK 1 uM":"287928.3455","33 HS578T DMM 5 mM":"275623.9161","36 HS578T DMM 5 mM":"389232.0258","35 HS578T Combination":"268424.4560","38 HS578T Combination":"251464.0279","16 MCF7 GSK 1 uM":"326360.6897","19 MCF7 GSK 1 uM":"470004.4649","15 MCF7 DMM 5 mM":"489433.5812","18 MCF7 DMM 5 mM":"399351.4238","17 MCF7 Combination":"420262.6971","20 MCF7 Combination":"244412.7616","28 MDA-MB-231 GSK 1 uM":"194679.6862","31 MDA-MB-231 GSK 1 uM":"257774.7050","27 MDA-MB-231 DMM 5 mM":"203648.8485","30 MDA-MB-231 DMM 5 mM":"228033.7243","29 MDA-MB-231 Combination":"307625.9655","32 MDA-MB-231 Combination":"316385.5438","04 MDA-MB-468 GSK 1 uM":"490993.4662","07 MDA-MB-468 GSK 1 uM":"455938.8247","03 MDA-MB-468 DMM 5 mM":"651815.2632","06 MDA-MB-468 DMM 5 mM":"477185.1797","05 MDA-MB-468 Combination":"521502.2855","08 MDA-MB-468 Combination":"796393.0403","01 Blank":"2312.7035","46 Blank":"3735.2120","02 DMEM/F12 no adds":"1177514.4920","45 DMEM/F12 no adds":"2698070.5340","10 SUM159PT GSK 1 uM":"277212.0524","13 SUM159PT GSK 1 uM":"328290.9273","09 SUM159PT DMM 5 mM":"323191.7662","12 SUM159PT DMM 5 mM":"285511.7013","11 SUM159PT Combination":"274101.4099","14 SUM159PT Combination":"303036.2922"},{"Metabolite":"Inosine 137","40 CAL120 GSK 1 uM":"5667876.7970","43 CAL120 GSK 1 uM":"6061037.2110","39 CAL120 DMM 5 mM":"3701963.8970","42 CAL120 DMM 5 mM":"3041520.9780","41 CAL120 Combination":"3403689.6690","44 CAL120 Combination":"3957356.8370","22 HCC1806 GSK 1 uM":"227941.0661","25 HCC1806 GSK 1 uM":"214265.4646","21 HCC1806 DMM 5 mM":"185016.2714","24 HCC1806 DMM 5 mM":"179554.3764","23 HCC1806 Combination":"189113.2081","26 HCC1806 Combination":"187374.3713","34 HS578T GSK 1 uM":"554293.9994","37 HS578T GSK 1 uM":"526804.1665","33 HS578T DMM 5 mM":"477119.3749","36 HS578T DMM 5 mM":"567763.8533","35 HS578T Combination":"643099.5377","38 HS578T Combination":"458488.5152","16 MCF7 GSK 1 uM":"252491.4115","19 MCF7 GSK 1 uM":"287286.8686","15 MCF7 DMM 5 mM":"128997.4618","18 MCF7 DMM 5 mM":"122548.6755","17 MCF7 Combination":"184766.3848","20 MCF7 Combination":"132868.8160","28 MDA-MB-231 GSK 1 uM":"670617.0065","31 MDA-MB-231 GSK 1 uM":"774004.5216","27 MDA-MB-231 DMM 5 mM":"560470.6930","30 MDA-MB-231 DMM 5 mM":"853448.0641","29 MDA-MB-231 Combination":"991265.5758","32 MDA-MB-231 Combination":"929216.9724","04 MDA-MB-468 GSK 1 uM":"593065.4138","07 MDA-MB-468 GSK 1 uM":"592740.9465","03 MDA-MB-468 DMM 5 mM":"494761.0845","06 MDA-MB-468 DMM 5 mM":"505217.8088","05 MDA-MB-468 Combination":"668531.2358","08 MDA-MB-468 Combination":"723117.5118","01 Blank":"493.1479","46 Blank":"434.8235","02 DMEM/F12 no adds":"49994.7513","45 DMEM/F12 no adds":"40142.9775","10 SUM159PT GSK 1 uM":"382036.9814","13 SUM159PT GSK 1 uM":"420648.1685","09 SUM159PT DMM 5 mM":"336187.7393","12 SUM159PT DMM 5 mM":"293860.0291","11 SUM159PT Combination":"317882.4306","14 SUM159PT Combination":"369862.1763"},{"Metabolite":"Isoleucine 69","40 CAL120 GSK 1 uM":"16151405.9600","43 CAL120 GSK 1 uM":"17214612.7200","39 CAL120 DMM 5 mM":"21973151.6900","42 CAL120 DMM 5 mM":"17026323.7700","41 CAL120 Combination":"17434013.4100","44 CAL120 Combination":"17116144.9100","22 HCC1806 GSK 1 uM":"59780947.1300","25 HCC1806 GSK 1 uM":"57432715.6400","21 HCC1806 DMM 5 mM":"66336627.9400","24 HCC1806 DMM 5 mM":"64073957.7700","23 HCC1806 Combination":"63312910.5500","26 HCC1806 Combination":"65409296.0200","34 HS578T GSK 1 uM":"24545701.1800","37 HS578T GSK 1 uM":"26543098.2200","33 HS578T DMM 5 mM":"19954196.3300","36 HS578T DMM 5 mM":"22196819.9500","35 HS578T Combination":"25249713.8100","38 HS578T Combination":"19767633.2700","16 MCF7 GSK 1 uM":"28209920.0100","19 MCF7 GSK 1 uM":"34061005.8000","15 MCF7 DMM 5 mM":"36958023.5400","18 MCF7 DMM 5 mM":"39937380.3200","17 MCF7 Combination":"35220486.4800","20 MCF7 Combination":"20560507.0200","28 MDA-MB-231 GSK 1 uM":"21039620.3600","31 MDA-MB-231 GSK 1 uM":"23699545.6000","27 MDA-MB-231 DMM 5 mM":"20941942.2300","30 MDA-MB-231 DMM 5 mM":"23487096.1800","29 MDA-MB-231 Combination":"19911366.8900","32 MDA-MB-231 Combination":"20971034.1600","04 MDA-MB-468 GSK 1 uM":"53626757.3600","07 MDA-MB-468 GSK 1 uM":"54337509.8300","03 MDA-MB-468 DMM 5 mM":"55672562.7500","06 MDA-MB-468 DMM 5 mM":"52191201.3600","05 MDA-MB-468 Combination":"49227795.0600","08 MDA-MB-468 Combination":"56464721.6000","01 Blank":"2459.2942","46 Blank":"6389.8500","02 DMEM/F12 no adds":"75446260.7600","45 DMEM/F12 no adds":"81895861.3600","10 SUM159PT GSK 1 uM":"25342899.7600","13 SUM159PT GSK 1 uM":"33538899.5400","09 SUM159PT DMM 5 mM":"25627408.4700","12 SUM159PT DMM 5 mM":"23906301.0800","11 SUM159PT Combination":"22907001.5900","14 SUM159PT Combination":"29023232.5900"},{"Metabolite":"Leucine 86","40 CAL120 GSK 1 uM":"9616002.0340","43 CAL120 GSK 1 uM":"7110436.9340","39 CAL120 DMM 5 mM":"12819974.0800","42 CAL120 DMM 5 mM":"30587902.1400","41 CAL120 Combination":"12051916.0000","44 CAL120 Combination":"10588870.4300","22 HCC1806 GSK 1 uM":"96897976.5500","25 HCC1806 GSK 1 uM":"94282055.9600","21 HCC1806 DMM 5 mM":"111551263.5000","24 HCC1806 DMM 5 mM":"106982558.6000","23 HCC1806 Combination":"40452081.8600","26 HCC1806 Combination":"110056928.3000","34 HS578T GSK 1 uM":"43090581.4600","37 HS578T GSK 1 uM":"47832612.8700","33 HS578T DMM 5 mM":"11896610.0400","36 HS578T DMM 5 mM":"38431583.1000","35 HS578T Combination":"11777861.3500","38 HS578T Combination":"11920357.5800","16 MCF7 GSK 1 uM":"46647813.7200","19 MCF7 GSK 1 uM":"17861645.5900","15 MCF7 DMM 5 mM":"21503174.1900","18 MCF7 DMM 5 mM":"65894698.2900","17 MCF7 Combination":"58757523.3800","20 MCF7 Combination":"11268426.7300","28 MDA-MB-231 GSK 1 uM":"12507528.7700","31 MDA-MB-231 GSK 1 uM":"39339893.2300","27 MDA-MB-231 DMM 5 mM":"9544242.4740","30 MDA-MB-231 DMM 5 mM":"13135743.6000","29 MDA-MB-231 Combination":"10030312.4800","32 MDA-MB-231 Combination":"11782237.8200","04 MDA-MB-468 GSK 1 uM":"86763041.5400","07 MDA-MB-468 GSK 1 uM":"87774771.9400","03 MDA-MB-468 DMM 5 mM":"87250491.8900","06 MDA-MB-468 DMM 5 mM":"82719722.5700","05 MDA-MB-468 Combination":"76595372.9500","08 MDA-MB-468 Combination":"90533461.5400","01 Blank":"2389.7728","46 Blank":"6302.0502","02 DMEM/F12 no adds":"29615119.7300","45 DMEM/F12 no adds":"31156548.1600","10 SUM159PT GSK 1 uM":"41023901.6700","13 SUM159PT GSK 1 uM":"55264768.9100","09 SUM159PT DMM 5 mM":"40886585.3700","12 SUM159PT DMM 5 mM":"40006344.0800","11 SUM159PT Combination":"13668337.5300","14 SUM159PT Combination":"44706336.9800"},{"Metabolite":"Lysine 84","40 CAL120 GSK 1 uM":"1763010.3830","43 CAL120 GSK 1 uM":"1630758.9470","39 CAL120 DMM 5 mM":"2435838.5890","42 CAL120 DMM 5 mM":"1741512.5260","41 CAL120 Combination":"1723775.4380","44 CAL120 Combination":"1306056.2070","22 HCC1806 GSK 1 uM":"4218144.3030","25 HCC1806 GSK 1 uM":"4159918.8860","21 HCC1806 DMM 5 mM":"7480499.2570","24 HCC1806 DMM 5 mM":"5471529.8960","23 HCC1806 Combination":"5383949.5270","26 HCC1806 Combination":"5743535.6330","34 HS578T GSK 1 uM":"1225149.0890","37 HS578T GSK 1 uM":"1869681.4010","33 HS578T DMM 5 mM":"1543024.9980","36 HS578T DMM 5 mM":"1171362.6920","35 HS578T Combination":"1615234.1810","38 HS578T Combination":"1118088.0220","16 MCF7 GSK 1 uM":"3314502.1930","19 MCF7 GSK 1 uM":"3730507.0270","15 MCF7 DMM 5 mM":"4168710.0520","18 MCF7 DMM 5 mM":"4896603.3890","17 MCF7 Combination":"3678469.8730","20 MCF7 Combination":"2104715.6040","28 MDA-MB-231 GSK 1 uM":"2394824.1030","31 MDA-MB-231 GSK 1 uM":"2144842.9240","27 MDA-MB-231 DMM 5 mM":"2463372.2890","30 MDA-MB-231 DMM 5 mM":"2854017.4850","29 MDA-MB-231 Combination":"2213369.8890","32 MDA-MB-231 Combination":"2072100.7770","04 MDA-MB-468 GSK 1 uM":"4172569.4640","07 MDA-MB-468 GSK 1 uM":"4373750.0690","03 MDA-MB-468 DMM 5 mM":"5893934.8480","06 MDA-MB-468 DMM 5 mM":"5367342.9470","05 MDA-MB-468 Combination":"3846766.9490","08 MDA-MB-468 Combination":"5946009.3030","01 Blank":"19366.1203","46 Blank":"97627.8486","02 DMEM/F12 no adds":"53324392.3500","45 DMEM/F12 no adds":"81887929.7400","10 SUM159PT GSK 1 uM":"2002391.2020","13 SUM159PT GSK 1 uM":"2375628.7370","09 SUM159PT DMM 5 mM":"2132599.6250","12 SUM159PT DMM 5 mM":"1949615.8900","11 SUM159PT Combination":"2213466.7060","14 SUM159PT Combination":"2480909.5640"},{"Metabolite":"Malonyl-CoA 303","40 CAL120 GSK 1 uM":"1127938.5910","43 CAL120 GSK 1 uM":"1087656.8340","39 CAL120 DMM 5 mM":"38282.6098","42 CAL120 DMM 5 mM":"37520.4185","41 CAL120 Combination":"930501.3983","44 CAL120 Combination":"991057.6952","22 HCC1806 GSK 1 uM":"1252052.3260","25 HCC1806 GSK 1 uM":"1392495.2810","21 HCC1806 DMM 5 mM":"48322.5728","24 HCC1806 DMM 5 mM":"57668.2176","23 HCC1806 Combination":"964821.2981","26 HCC1806 Combination":"1058499.5170","34 HS578T GSK 1 uM":"212615.3043","37 HS578T GSK 1 uM":"232247.7904","33 HS578T DMM 5 mM":"12218.0700","36 HS578T DMM 5 mM":"9537.9011","35 HS578T Combination":"64001.0398","38 HS578T Combination":"33867.4033","16 MCF7 GSK 1 uM":"1114306.0900","19 MCF7 GSK 1 uM":"1341110.4330","15 MCF7 DMM 5 mM":"38795.1883","18 MCF7 DMM 5 mM":"31033.0169","17 MCF7 Combination":"1248170.5850","20 MCF7 Combination":"712017.2776","28 MDA-MB-231 GSK 1 uM":"981708.2083","31 MDA-MB-231 GSK 1 uM":"1011400.5740","27 MDA-MB-231 DMM 5 mM":"167047.1394","30 MDA-MB-231 DMM 5 mM":"160780.2526","29 MDA-MB-231 Combination":"690141.1473","32 MDA-MB-231 Combination":"925001.8331","04 MDA-MB-468 GSK 1 uM":"1597676.3130","07 MDA-MB-468 GSK 1 uM":"1727108.0340","03 MDA-MB-468 DMM 5 mM":"75162.3384","06 MDA-MB-468 DMM 5 mM":"87164.0820","05 MDA-MB-468 Combination":"1577796.4130","08 MDA-MB-468 Combination":"1537174.0650","01 Blank":"167.0103","46 Blank":"157.5869","02 DMEM/F12 no adds":"126.5396","45 DMEM/F12 no adds":"796.9479","10 SUM159PT GSK 1 uM":"1486486.8670","13 SUM159PT GSK 1 uM":"1788415.8940","09 SUM159PT DMM 5 mM":"54236.5241","12 SUM159PT DMM 5 mM":"58781.5482","11 SUM159PT Combination":"1169767.4740","14 SUM159PT Combination":"1121580.4920"},{"Metabolite":"Malonyl-CoA 428","40 CAL120 GSK 1 uM":"952678.9242","43 CAL120 GSK 1 uM":"1005360.3850","39 CAL120 DMM 5 mM":"33550.5959","42 CAL120 DMM 5 mM":"35609.1545","41 CAL120 Combination":"770217.4658","44 CAL120 Combination":"899956.4118","22 HCC1806 GSK 1 uM":"1091237.5360","25 HCC1806 GSK 1 uM":"1193203.7380","21 HCC1806 DMM 5 mM":"40247.4458","24 HCC1806 DMM 5 mM":"45703.2047","23 HCC1806 Combination":"874846.4947","26 HCC1806 Combination":"893112.6070","34 HS578T GSK 1 uM":"178904.3631","37 HS578T GSK 1 uM":"186580.4353","33 HS578T DMM 5 mM":"12116.3156","36 HS578T DMM 5 mM":"7360.6780","35 HS578T Combination":"56235.1305","38 HS578T Combination":"26143.7983","16 MCF7 GSK 1 uM":"976741.5890","19 MCF7 GSK 1 uM":"1160829.5630","15 MCF7 DMM 5 mM":"37249.9928","18 MCF7 DMM 5 mM":"27136.2334","17 MCF7 Combination":"1112004.3310","20 MCF7 Combination":"603040.1666","28 MDA-MB-231 GSK 1 uM":"824780.4334","31 MDA-MB-231 GSK 1 uM":"890569.5010","27 MDA-MB-231 DMM 5 mM":"144879.9837","30 MDA-MB-231 DMM 5 mM":"130390.5918","29 MDA-MB-231 Combination":"571590.2531","32 MDA-MB-231 Combination":"823142.5415","04 MDA-MB-468 GSK 1 uM":"1316428.8980","07 MDA-MB-468 GSK 1 uM":"1374126.7300","03 MDA-MB-468 DMM 5 mM":"68505.0881","06 MDA-MB-468 DMM 5 mM":"76193.4955","05 MDA-MB-468 Combination":"1356680.9730","08 MDA-MB-468 Combination":"1242776.2720","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no 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Combination":"24272968.9600","14 SUM159PT Combination":"28339376.8600"},{"Metabolite":"Methionine 61","40 CAL120 GSK 1 uM":"10545863.8200","43 CAL120 GSK 1 uM":"10460035.4200","39 CAL120 DMM 5 mM":"12253920.3500","42 CAL120 DMM 5 mM":"10145141.1400","41 CAL120 Combination":"9693887.5760","44 CAL120 Combination":"9866061.8600","22 HCC1806 GSK 1 uM":"29092590.5500","25 HCC1806 GSK 1 uM":"28595614.6100","21 HCC1806 DMM 5 mM":"36211134.3600","24 HCC1806 DMM 5 mM":"33320977.6600","23 HCC1806 Combination":"34003410.2300","26 HCC1806 Combination":"35881557.8500","34 HS578T GSK 1 uM":"11888600.2100","37 HS578T GSK 1 uM":"13584305.7500","33 HS578T DMM 5 mM":"9460659.9090","36 HS578T DMM 5 mM":"9875677.4510","35 HS578T Combination":"11872183.0200","38 HS578T Combination":"9289888.9460","16 MCF7 GSK 1 uM":"12638371.8900","19 MCF7 GSK 1 uM":"15183957.4100","15 MCF7 DMM 5 mM":"16807214.7900","18 MCF7 DMM 5 mM":"17762197.5100","17 MCF7 Combination":"15000976.6800","20 MCF7 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DMEM/F12 no adds":"456.4416","10 SUM159PT GSK 1 uM":"311.8163","13 SUM159PT GSK 1 uM":"","09 SUM159PT DMM 5 mM":"298.4295","12 SUM159PT DMM 5 mM":"","11 SUM159PT Combination":"","14 SUM159PT Combination":""},{"Metabolite":"Methotrexate 308","40 CAL120 GSK 1 uM":"333.6194","43 CAL120 GSK 1 uM":"352.0844","39 CAL120 DMM 5 mM":"654.8403","42 CAL120 DMM 5 mM":"570.8208","41 CAL120 Combination":"492.5663","44 CAL120 Combination":"1046.0167","22 HCC1806 GSK 1 uM":"1549.3790","25 HCC1806 GSK 1 uM":"452.3599","21 HCC1806 DMM 5 mM":"1514.4150","24 HCC1806 DMM 5 mM":"165.8376","23 HCC1806 Combination":"1161.2468","26 HCC1806 Combination":"715.4516","34 HS578T GSK 1 uM":"809.6018","37 HS578T GSK 1 uM":"636.4873","33 HS578T DMM 5 mM":"811.4821","36 HS578T DMM 5 mM":"1308.5395","35 HS578T Combination":"807.6412","38 HS578T Combination":"447.1627","16 MCF7 GSK 1 uM":"1150.7095","19 MCF7 GSK 1 uM":"521.3529","15 MCF7 DMM 5 mM":"650.6168","18 MCF7 DMM 5 mM":"822.8321","17 MCF7 Combination":"989.5609","20 MCF7 Combination":"640.6977","28 MDA-MB-231 GSK 1 uM":"987.7090","31 MDA-MB-231 GSK 1 uM":"1078.3675","27 MDA-MB-231 DMM 5 mM":"496.9154","30 MDA-MB-231 DMM 5 mM":"997.3819","29 MDA-MB-231 Combination":"502.5961","32 MDA-MB-231 Combination":"1696.4108","04 MDA-MB-468 GSK 1 uM":"678.9016","07 MDA-MB-468 GSK 1 uM":"541.4545","03 MDA-MB-468 DMM 5 mM":"1085.3483","06 MDA-MB-468 DMM 5 mM":"1136.9563","05 MDA-MB-468 Combination":"333.4928","08 MDA-MB-468 Combination":"953.2123","01 Blank":"1107.5689","46 Blank":"810.8002","02 DMEM/F12 no adds":"1307.8707","45 DMEM/F12 no adds":"1281.4701","10 SUM159PT GSK 1 uM":"1084.0788","13 SUM159PT GSK 1 uM":"449.9185","09 SUM159PT DMM 5 mM":"509.7577","12 SUM159PT DMM 5 mM":"651.0192","11 SUM159PT Combination":"330.1547","14 SUM159PT Combination":"1324.6460"},{"Metabolite":"Methylcobalamin 147","40 CAL120 GSK 1 uM":"426.3120","43 CAL120 GSK 1 uM":"498.6535","39 CAL120 DMM 5 mM":"937.1281","42 CAL120 DMM 5 mM":"1427.3576","41 CAL120 Combination":"1144.3965","44 CAL120 Combination":"622.9039","22 HCC1806 GSK 1 uM":"1139.4253","25 HCC1806 GSK 1 uM":"933.5044","21 HCC1806 DMM 5 mM":"1094.3078","24 HCC1806 DMM 5 mM":"831.5753","23 HCC1806 Combination":"679.6663","26 HCC1806 Combination":"861.1180","34 HS578T GSK 1 uM":"406.1109","37 HS578T GSK 1 uM":"302.5656","33 HS578T DMM 5 mM":"347.4582","36 HS578T DMM 5 mM":"264.0572","35 HS578T Combination":"531.4401","38 HS578T Combination":"425.8330","16 MCF7 GSK 1 uM":"657.6707","19 MCF7 GSK 1 uM":"528.3988","15 MCF7 DMM 5 mM":"729.1070","18 MCF7 DMM 5 mM":"978.7181","17 MCF7 Combination":"499.0058","20 MCF7 Combination":"226.7527","28 MDA-MB-231 GSK 1 uM":"994.7037","31 MDA-MB-231 GSK 1 uM":"231.0916","27 MDA-MB-231 DMM 5 mM":"559.6393","30 MDA-MB-231 DMM 5 mM":"550.3032","29 MDA-MB-231 Combination":"292.5371","32 MDA-MB-231 Combination":"395.4649","04 MDA-MB-468 GSK 1 uM":"958.9018","07 MDA-MB-468 GSK 1 uM":"1340.8637","03 MDA-MB-468 DMM 5 mM":"573.3749","06 MDA-MB-468 DMM 5 mM":"920.9733","05 MDA-MB-468 Combination":"497.2632","08 MDA-MB-468 Combination":"995.7756","01 Blank":"85.9920","46 Blank":"172.0141","02 DMEM/F12 no adds":"669.7476","45 DMEM/F12 no adds":"675.3913","10 SUM159PT GSK 1 uM":"767.2439","13 SUM159PT GSK 1 uM":"1035.5615","09 SUM159PT DMM 5 mM":"1009.6594","12 SUM159PT DMM 5 mM":"779.0488","11 SUM159PT Combination":"319.9291","14 SUM159PT Combination":"584.6167"},{"Metabolite":"Methylcobalamin 636","40 CAL120 GSK 1 uM":"","43 CAL120 GSK 1 uM":"","39 CAL120 DMM 5 mM":"","42 CAL120 DMM 5 mM":"","41 CAL120 Combination":"","44 CAL120 Combination":"","22 HCC1806 GSK 1 uM":"","25 HCC1806 GSK 1 uM":"","21 HCC1806 DMM 5 mM":"","24 HCC1806 DMM 5 mM":"","23 HCC1806 Combination":"","26 HCC1806 Combination":"","34 HS578T GSK 1 uM":"","37 HS578T GSK 1 uM":"","33 HS578T DMM 5 mM":"","36 HS578T DMM 5 mM":"","35 HS578T Combination":"","38 HS578T Combination":"","16 MCF7 GSK 1 uM":"","19 MCF7 GSK 1 uM":"","15 MCF7 DMM 5 mM":"","18 MCF7 DMM 5 mM":"","17 MCF7 Combination":"","20 MCF7 Combination":"","28 MDA-MB-231 GSK 1 uM":"","31 MDA-MB-231 GSK 1 uM":"","27 MDA-MB-231 DMM 5 mM":"","30 MDA-MB-231 DMM 5 mM":"","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"","04 MDA-MB-468 GSK 1 uM":"","07 MDA-MB-468 GSK 1 uM":"","03 MDA-MB-468 DMM 5 mM":"","06 MDA-MB-468 DMM 5 mM":"","05 MDA-MB-468 Combination":"","08 MDA-MB-468 Combination":"","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"","13 SUM159PT GSK 1 uM":"","09 SUM159PT DMM 5 mM":"","12 SUM159PT DMM 5 mM":"","11 SUM159PT Combination":"","14 SUM159PT Combination":""},{"Metabolite":"Myristoyl-CoA 428","40 CAL120 GSK 1 uM":"10508.9276","43 CAL120 GSK 1 uM":"5628.7011","39 CAL120 DMM 5 mM":"28512.0760","42 CAL120 DMM 5 mM":"36260.0409","41 CAL120 Combination":"11764.7197","44 CAL120 Combination":"12702.8072","22 HCC1806 GSK 1 uM":"18126.0715","25 HCC1806 GSK 1 uM":"21661.4151","21 HCC1806 DMM 5 mM":"29749.8724","24 HCC1806 DMM 5 mM":"33928.8640","23 HCC1806 Combination":"21631.4179","26 HCC1806 Combination":"19762.4502","34 HS578T GSK 1 uM":"5621.6576","37 HS578T GSK 1 uM":"5725.0225","33 HS578T DMM 5 mM":"6942.0031","36 HS578T DMM 5 mM":"6884.0795","35 HS578T Combination":"9608.5729","38 HS578T Combination":"3660.6230","16 MCF7 GSK 1 uM":"2790.3843","19 MCF7 GSK 1 uM":"3663.7661","15 MCF7 DMM 5 mM":"62306.2009","18 MCF7 DMM 5 mM":"39436.6254","17 MCF7 Combination":"4442.4010","20 MCF7 Combination":"3325.0492","28 MDA-MB-231 GSK 1 uM":"6768.2997","31 MDA-MB-231 GSK 1 uM":"5498.7615","27 MDA-MB-231 DMM 5 mM":"18922.7841","30 MDA-MB-231 DMM 5 mM":"18946.4815","29 MDA-MB-231 Combination":"5630.4741","32 MDA-MB-231 Combination":"8119.0272","04 MDA-MB-468 GSK 1 uM":"12166.7902","07 MDA-MB-468 GSK 1 uM":"9528.5466","03 MDA-MB-468 DMM 5 mM":"36689.1205","06 MDA-MB-468 DMM 5 mM":"62238.4266","05 MDA-MB-468 Combination":"17949.6269","08 MDA-MB-468 Combination":"25087.7382","01 Blank":"110.5800","46 Blank":"","02 DMEM/F12 no adds":"449.4910","45 DMEM/F12 no adds":"113.1112","10 SUM159PT GSK 1 uM":"8696.0935","13 SUM159PT GSK 1 uM":"11368.8114","09 SUM159PT DMM 5 mM":"17189.5982","12 SUM159PT DMM 5 mM":"35729.4791","11 SUM159PT Combination":"13910.0913","14 SUM159PT Combination":"10911.5829"},{"Metabolite":"NAD+ 428","40 CAL120 GSK 1 uM":"17460331.9000","43 CAL120 GSK 1 uM":"16572721.6800","39 CAL120 DMM 5 mM":"14227910.9300","42 CAL120 DMM 5 mM":"14673562.1600","41 CAL120 Combination":"14767999.5100","44 CAL120 Combination":"15639062.8900","22 HCC1806 GSK 1 uM":"27272896.3300","25 HCC1806 GSK 1 uM":"25709493.4500","21 HCC1806 DMM 5 mM":"23796238.6800","24 HCC1806 DMM 5 mM":"26225969.7700","23 HCC1806 Combination":"27758250.6600","26 HCC1806 Combination":"27552252.6400","34 HS578T GSK 1 uM":"6754409.8760","37 HS578T GSK 1 uM":"6651162.2460","33 HS578T DMM 5 mM":"4408124.3070","36 HS578T DMM 5 mM":"4868478.4860","35 HS578T Combination":"5529780.4720","38 HS578T Combination":"5016445.9850","16 MCF7 GSK 1 uM":"12103724.0200","19 MCF7 GSK 1 uM":"14584399.3300","15 MCF7 DMM 5 mM":"15646717.1200","18 MCF7 DMM 5 mM":"14431862.5500","17 MCF7 Combination":"17494200.0000","20 MCF7 Combination":"10410728.3300","28 MDA-MB-231 GSK 1 uM":"14238950.5000","31 MDA-MB-231 GSK 1 uM":"17421167.6900","27 MDA-MB-231 DMM 5 mM":"15801094.6400","30 MDA-MB-231 DMM 5 mM":"15422165.1900","29 MDA-MB-231 Combination":"14723885.5400","32 MDA-MB-231 Combination":"16174723.7200","04 MDA-MB-468 GSK 1 uM":"29487545.8100","07 MDA-MB-468 GSK 1 uM":"28559347.0900","03 MDA-MB-468 DMM 5 mM":"25180487.1200","06 MDA-MB-468 DMM 5 mM":"24621376.8300","05 MDA-MB-468 Combination":"25634158.7200","08 MDA-MB-468 Combination":"25364688.4200","01 Blank":"1363.7709","46 Blank":"2783.7135","02 DMEM/F12 no adds":"1182.8811","45 DMEM/F12 no adds":"19592.8012","10 SUM159PT GSK 1 uM":"25121945.0100","13 SUM159PT GSK 1 uM":"28805045.2400","09 SUM159PT DMM 5 mM":"24617246.6100","12 SUM159PT DMM 5 mM":"26608686.6100","11 SUM159PT Combination":"26339029.1100","14 SUM159PT Combination":"27587836.8400"},{"Metabolite":"NAD+ 524","40 CAL120 GSK 1 uM":"9933775.4140","43 CAL120 GSK 1 uM":"9094507.2630","39 CAL120 DMM 5 mM":"9494181.2200","42 CAL120 DMM 5 mM":"9399852.8540","41 CAL120 Combination":"9768607.1820","44 CAL120 Combination":"9776549.8110","22 HCC1806 GSK 1 uM":"19482281.3700","25 HCC1806 GSK 1 uM":"19347810.4300","21 HCC1806 DMM 5 mM":"17340731.6700","24 HCC1806 DMM 5 mM":"16403507.0500","23 HCC1806 Combination":"20107957.4400","26 HCC1806 Combination":"19666750.3500","34 HS578T GSK 1 uM":"4818610.3780","37 HS578T GSK 1 uM":"4694456.7130","33 HS578T DMM 5 mM":"3295539.6410","36 HS578T DMM 5 mM":"3398429.7900","35 HS578T Combination":"4056658.6010","38 HS578T Combination":"3520808.4910","16 MCF7 GSK 1 uM":"8271979.2270","19 MCF7 GSK 1 uM":"9074194.8990","15 MCF7 DMM 5 mM":"10876828.2400","18 MCF7 DMM 5 mM":"10267602.2000","17 MCF7 Combination":"10605854.5000","20 MCF7 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mM":"257324.7559","42 CAL120 DMM 5 mM":"235849.7871","41 CAL120 Combination":"240310.1495","44 CAL120 Combination":"238945.7181","22 HCC1806 GSK 1 uM":"844018.4637","25 HCC1806 GSK 1 uM":"1104402.5690","21 HCC1806 DMM 5 mM":"956505.0083","24 HCC1806 DMM 5 mM":"699617.1734","23 HCC1806 Combination":"579992.2560","26 HCC1806 Combination":"726699.8866","34 HS578T GSK 1 uM":"225465.8582","37 HS578T GSK 1 uM":"289081.3450","33 HS578T DMM 5 mM":"265176.4546","36 HS578T DMM 5 mM":"271783.3505","35 HS578T Combination":"321788.1919","38 HS578T Combination":"195690.9065","16 MCF7 GSK 1 uM":"294303.5093","19 MCF7 GSK 1 uM":"307945.0107","15 MCF7 DMM 5 mM":"244278.0555","18 MCF7 DMM 5 mM":"249795.0797","17 MCF7 Combination":"224461.4762","20 MCF7 Combination":"134915.2960","28 MDA-MB-231 GSK 1 uM":"701235.7422","31 MDA-MB-231 GSK 1 uM":"594913.4245","27 MDA-MB-231 DMM 5 mM":"602404.4514","30 MDA-MB-231 DMM 5 mM":"657865.4632","29 MDA-MB-231 Combination":"447906.5335","32 MDA-MB-231 Combination":"456592.5887","04 MDA-MB-468 GSK 1 uM":"1599759.4420","07 MDA-MB-468 GSK 1 uM":"1689921.0170","03 MDA-MB-468 DMM 5 mM":"1074597.0650","06 MDA-MB-468 DMM 5 mM":"1284510.5440","05 MDA-MB-468 Combination":"1055455.5340","08 MDA-MB-468 Combination":"1325973.1790","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"749501.8432","13 SUM159PT GSK 1 uM":"904955.7299","09 SUM159PT DMM 5 mM":"560863.1020","12 SUM159PT DMM 5 mM":"496597.7254","11 SUM159PT Combination":"497101.2625","14 SUM159PT Combination":"567286.7336"},{"Metabolite":"NADH 649","40 CAL120 GSK 1 uM":"729189.0482","43 CAL120 GSK 1 uM":"630073.2684","39 CAL120 DMM 5 mM":"638443.6165","42 CAL120 DMM 5 mM":"577335.3704","41 CAL120 Combination":"650313.6805","44 CAL120 Combination":"587111.2036","22 HCC1806 GSK 1 uM":"1974091.3860","25 HCC1806 GSK 1 uM":"2746672.0810","21 HCC1806 DMM 5 mM":"2365731.4910","24 HCC1806 DMM 5 mM":"1726136.6170","23 HCC1806 Combination":"1388672.6260","26 HCC1806 Combination":"1908158.9640","34 HS578T GSK 1 uM":"571712.6029","37 HS578T GSK 1 uM":"723486.8584","33 HS578T DMM 5 mM":"705226.8330","36 HS578T DMM 5 mM":"670272.5217","35 HS578T Combination":"804230.2863","38 HS578T Combination":"464160.4614","16 MCF7 GSK 1 uM":"762812.2466","19 MCF7 GSK 1 uM":"758535.1276","15 MCF7 DMM 5 mM":"620388.7425","18 MCF7 DMM 5 mM":"622010.7715","17 MCF7 Combination":"555640.4062","20 MCF7 Combination":"297993.7015","28 MDA-MB-231 GSK 1 uM":"1702721.8910","31 MDA-MB-231 GSK 1 uM":"1535419.2480","27 MDA-MB-231 DMM 5 mM":"1466695.4770","30 MDA-MB-231 DMM 5 mM":"1611051.9410","29 MDA-MB-231 Combination":"1089553.7950","32 MDA-MB-231 Combination":"1136158.0230","04 MDA-MB-468 GSK 1 uM":"3792404.4720","07 MDA-MB-468 GSK 1 uM":"3881187.5660","03 MDA-MB-468 DMM 5 mM":"2528551.4330","06 MDA-MB-468 DMM 5 mM":"2893615.4800","05 MDA-MB-468 Combination":"2573371.4850","08 MDA-MB-468 Combination":"3233079.9910","01 Blank":"335.5477","46 Blank":"880.3912","02 DMEM/F12 no adds":"587.2607","45 DMEM/F12 no adds":"1470.2471","10 SUM159PT GSK 1 uM":"1800537.2990","13 SUM159PT GSK 1 uM":"2289056.7390","09 SUM159PT DMM 5 mM":"1257871.1490","12 SUM159PT DMM 5 mM":"1311425.4530","11 SUM159PT Combination":"1143899.0770","14 SUM159PT Combination":"1409407.0010"},{"Metabolite":"Niaciamide 106","40 CAL120 GSK 1 uM":"277.3444","43 CAL120 GSK 1 uM":"25947.1901","39 CAL120 DMM 5 mM":"55392.4976","42 CAL120 DMM 5 mM":"30911.8771","41 CAL120 Combination":"41274.3963","44 CAL120 Combination":"21457.8222","22 HCC1806 GSK 1 uM":"103121.6713","25 HCC1806 GSK 1 uM":"81968.3270","21 HCC1806 DMM 5 mM":"120804.0883","24 HCC1806 DMM 5 mM":"30195.6980","23 HCC1806 Combination":"28530.7468","26 HCC1806 Combination":"52674.6456","34 HS578T GSK 1 uM":"18414.5974","37 HS578T GSK 1 uM":"41597.6504","33 HS578T DMM 5 mM":"20599.6619","36 HS578T DMM 5 mM":"21325.6796","35 HS578T Combination":"32756.8290","38 HS578T Combination":"1782.5936","16 MCF7 GSK 1 uM":"59622.8384","19 MCF7 GSK 1 uM":"58745.7883","15 MCF7 DMM 5 mM":"30570.1951","18 MCF7 DMM 5 mM":"72431.7335","17 MCF7 Combination":"42283.2613","20 MCF7 Combination":"17951.1034","28 MDA-MB-231 GSK 1 uM":"59787.2746","31 MDA-MB-231 GSK 1 uM":"55541.8730","27 MDA-MB-231 DMM 5 mM":"37300.1564","30 MDA-MB-231 DMM 5 mM":"73564.7183","29 MDA-MB-231 Combination":"29889.4874","32 MDA-MB-231 Combination":"20943.9080","04 MDA-MB-468 GSK 1 uM":"105402.9791","07 MDA-MB-468 GSK 1 uM":"102039.7974","03 MDA-MB-468 DMM 5 mM":"89627.5246","06 MDA-MB-468 DMM 5 mM":"98745.6461","05 MDA-MB-468 Combination":"105641.7961","08 MDA-MB-468 Combination":"108485.3882","01 Blank":"1733.8280","46 Blank":"4613.9498","02 DMEM/F12 no adds":"912857.0736","45 DMEM/F12 no adds":"1074095.0490","10 SUM159PT GSK 1 uM":"30181.9337","13 SUM159PT GSK 1 uM":"19769.3396","09 SUM159PT DMM 5 mM":"19156.5526","12 SUM159PT DMM 5 mM":"30469.9454","11 SUM159PT Combination":"24727.4751","14 SUM159PT Combination":"14237.7625"},{"Metabolite":"Niaciamide 80","40 CAL120 GSK 1 uM":"3085862.9670","43 CAL120 GSK 1 uM":"2603660.0480","39 CAL120 DMM 5 mM":"3531351.8930","42 CAL120 DMM 5 mM":"2572980.0320","41 CAL120 Combination":"2357373.0540","44 CAL120 Combination":"2023913.1580","22 HCC1806 GSK 1 uM":"6322756.3670","25 HCC1806 GSK 1 uM":"5965092.6410","21 HCC1806 DMM 5 mM":"7010624.2270","24 HCC1806 DMM 5 mM":"3853742.6690","23 HCC1806 Combination":"3439269.9280","26 HCC1806 Combination":"3800289.0920","34 HS578T GSK 1 uM":"1231903.7450","37 HS578T GSK 1 uM":"2564785.9460","33 HS578T DMM 5 mM":"1643685.4160","36 HS578T DMM 5 mM":"1110648.5120","35 HS578T Combination":"1742641.2670","38 HS578T Combination":"1070312.3130","16 MCF7 GSK 1 uM":"4285208.9790","19 MCF7 GSK 1 uM":"4017242.1040","15 MCF7 DMM 5 mM":"3446278.5890","18 MCF7 DMM 5 mM":"4697699.8090","17 MCF7 Combination":"3175098.3550","20 MCF7 Combination":"2253320.2770","28 MDA-MB-231 GSK 1 uM":"3852585.9080","31 MDA-MB-231 GSK 1 uM":"3001941.2370","27 MDA-MB-231 DMM 5 mM":"3055515.7380","30 MDA-MB-231 DMM 5 mM":"3580421.4240","29 MDA-MB-231 Combination":"2634259.0810","32 MDA-MB-231 Combination":"1997623.1880","04 MDA-MB-468 GSK 1 uM":"7588563.3890","07 MDA-MB-468 GSK 1 uM":"7822448.4290","03 MDA-MB-468 DMM 5 mM":"5919282.4000","06 MDA-MB-468 DMM 5 mM":"5923307.3150","05 MDA-MB-468 Combination":"6354327.5520","08 MDA-MB-468 Combination":"6931419.6270","01 Blank":"37330.5348","46 Blank":"39377.8033","02 DMEM/F12 no adds":"50563586.1300","45 DMEM/F12 no adds":"57745110.5100","10 SUM159PT GSK 1 uM":"1501055.4680","13 SUM159PT GSK 1 uM":"2141833.3480","09 SUM159PT DMM 5 mM":"1549162.2900","12 SUM159PT DMM 5 mM":"1796516.3550","11 SUM159PT Combination":"1653349.2100","14 SUM159PT Combination":"1951765.9550"},{"Metabolite":"O-Acetyl-L-carnitine 145","40 CAL120 GSK 1 uM":"1013538.3410","43 CAL120 GSK 1 uM":"1095339.3410","39 CAL120 DMM 5 mM":"1336945.7090","42 CAL120 DMM 5 mM":"1250689.4930","41 CAL120 Combination":"1290653.9650","44 CAL120 Combination":"1369540.8670","22 HCC1806 GSK 1 uM":"802814.2229","25 HCC1806 GSK 1 uM":"786812.7539","21 HCC1806 DMM 5 mM":"565388.0732","24 HCC1806 DMM 5 mM":"601042.4128","23 HCC1806 Combination":"616389.2822","26 HCC1806 Combination":"613420.8159","34 HS578T GSK 1 uM":"501385.0477","37 HS578T GSK 1 uM":"486013.4249","33 HS578T DMM 5 mM":"493717.9570","36 HS578T DMM 5 mM":"501335.2289","35 HS578T Combination":"540194.8077","38 HS578T Combination":"54131.3326","16 MCF7 GSK 1 uM":"2168097.7290","19 MCF7 GSK 1 uM":"2761419.1850","15 MCF7 DMM 5 mM":"1105763.6310","18 MCF7 DMM 5 mM":"992565.8347","17 MCF7 Combination":"1534242.9890","20 MCF7 Combination":"1036544.6050","28 MDA-MB-231 GSK 1 uM":"814264.5910","31 MDA-MB-231 GSK 1 uM":"888002.3722","27 MDA-MB-231 DMM 5 mM":"871271.4912","30 MDA-MB-231 DMM 5 mM":"807922.0407","29 MDA-MB-231 Combination":"839218.7790","32 MDA-MB-231 Combination":"1177242.1110","04 MDA-MB-468 GSK 1 uM":"2024893.2450","07 MDA-MB-468 GSK 1 uM":"2081013.5830","03 MDA-MB-468 DMM 5 mM":"1847183.9300","06 MDA-MB-468 DMM 5 mM":"1653534.6820","05 MDA-MB-468 Combination":"1849856.5430","08 MDA-MB-468 Combination":"1717820.3030","01 Blank":"194.3539","46 Blank":"294.0089","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"","10 SUM159PT GSK 1 uM":"2970516.5840","13 SUM159PT GSK 1 uM":"3584094.6320","09 SUM159PT DMM 5 mM":"2340784.1900","12 SUM159PT DMM 5 mM":"2325960.3910","11 SUM159PT Combination":"2482539.9170","14 SUM159PT Combination":"2705397.2130"},{"Metabolite":"O-Acetyl-L-carnitine 85","40 CAL120 GSK 1 uM":"56763587.7100","43 CAL120 GSK 1 uM":"58662006.0300","39 CAL120 DMM 5 mM":"72979491.5500","42 CAL120 DMM 5 mM":"68037953.9800","41 CAL120 Combination":"68371216.9900","44 CAL120 Combination":"74765246.1600","22 HCC1806 GSK 1 uM":"44549848.1700","25 HCC1806 GSK 1 uM":"42763961.5200","21 HCC1806 DMM 5 mM":"30619924.4400","24 HCC1806 DMM 5 mM":"32271968.4600","23 HCC1806 Combination":"33581854.9600","26 HCC1806 Combination":"34224722.1000","34 HS578T GSK 1 uM":"27658679.0600","37 HS578T GSK 1 uM":"27737821.3300","33 HS578T DMM 5 mM":"27390265.6900","36 HS578T DMM 5 mM":"27074256.7100","35 HS578T Combination":"30701161.3600","38 HS578T Combination":"3194625.2400","16 MCF7 GSK 1 uM":"112826586.8000","19 MCF7 GSK 1 uM":"137768368.1000","15 MCF7 DMM 5 mM":"60995954.3200","18 MCF7 DMM 5 mM":"54284131.3400","17 MCF7 Combination":"84729491.7600","20 MCF7 Combination":"55998855.4600","28 MDA-MB-231 GSK 1 uM":"44752525.4500","31 MDA-MB-231 GSK 1 uM":"48228392.0000","27 MDA-MB-231 DMM 5 mM":"45678541.0200","30 MDA-MB-231 DMM 5 mM":"44879868.3200","29 MDA-MB-231 Combination":"46913702.3900","32 MDA-MB-231 Combination":"60727009.9000","04 MDA-MB-468 GSK 1 uM":"103281737.7000","07 MDA-MB-468 GSK 1 uM":"108926049.5000","03 MDA-MB-468 DMM 5 mM":"96303494.7900","06 MDA-MB-468 DMM 5 mM":"90230030.8600","05 MDA-MB-468 Combination":"95440681.2900","08 MDA-MB-468 Combination":"90979452.0000","01 Blank":"505.7655","46 Blank":"2378.9318","02 DMEM/F12 no adds":"963.7296","45 DMEM/F12 no adds":"1733.4962","10 SUM159PT GSK 1 uM":"144640903.8000","13 SUM159PT GSK 1 uM":"169428690.6000","09 SUM159PT DMM 5 mM":"121726459.8000","12 SUM159PT DMM 5 mM":"121244662.2000","11 SUM159PT Combination":"125010930.0000","14 SUM159PT Combination":"132900262.8000"},{"Metabolite":"O-Acyl(17:1)-L-carnitine 85","40 CAL120 GSK 1 uM":"11253.9861","43 CAL120 GSK 1 uM":"19707.5040","39 CAL120 DMM 5 mM":"29428.9878","42 CAL120 DMM 5 mM":"29767.9087","41 CAL120 Combination":"12435.2986","44 CAL120 Combination":"15640.6979","22 HCC1806 GSK 1 uM":"4670.6407","25 HCC1806 GSK 1 uM":"5851.2085","21 HCC1806 DMM 5 mM":"14339.4841","24 HCC1806 DMM 5 mM":"15025.5868","23 HCC1806 Combination":"8045.3936","26 HCC1806 Combination":"8501.8033","34 HS578T GSK 1 uM":"9448.2164","37 HS578T GSK 1 uM":"9431.4855","33 HS578T DMM 5 mM":"13499.5483","36 HS578T DMM 5 mM":"14815.2558","35 HS578T Combination":"8913.4603","38 HS578T Combination":"13520.1224","16 MCF7 GSK 1 uM":"10335.3193","19 MCF7 GSK 1 uM":"7969.5062","15 MCF7 DMM 5 mM":"25558.5740","18 MCF7 DMM 5 mM":"28721.5313","17 MCF7 Combination":"10904.2509","20 MCF7 Combination":"7458.3880","28 MDA-MB-231 GSK 1 uM":"5708.8494","31 MDA-MB-231 GSK 1 uM":"6189.7459","27 MDA-MB-231 DMM 5 mM":"9691.6138","30 MDA-MB-231 DMM 5 mM":"5634.3446","29 MDA-MB-231 Combination":"9817.1394","32 MDA-MB-231 Combination":"6449.3900","04 MDA-MB-468 GSK 1 uM":"7106.8247","07 MDA-MB-468 GSK 1 uM":"7108.1796","03 MDA-MB-468 DMM 5 mM":"10304.1491","06 MDA-MB-468 DMM 5 mM":"5437.1254","05 MDA-MB-468 Combination":"3720.4517","08 MDA-MB-468 Combination":"9987.0354","01 Blank":"1140.1385","46 Blank":"744.2581","02 DMEM/F12 no adds":"1138.1535","45 DMEM/F12 no adds":"833.4096","10 SUM159PT GSK 1 uM":"4308.7143","13 SUM159PT GSK 1 uM":"6835.6973","09 SUM159PT DMM 5 mM":"14263.7556","12 SUM159PT DMM 5 mM":"18475.8152","11 SUM159PT Combination":"5924.1956","14 SUM159PT Combination":"7049.2066"},{"Metabolite":"O-Butyryl-L-carnitine 85","40 CAL120 GSK 1 uM":"785403.3911","43 CAL120 GSK 1 uM":"870293.3432","39 CAL120 DMM 5 mM":"7493098.4210","42 CAL120 DMM 5 mM":"6482020.0470","41 CAL120 Combination":"568578.3074","44 CAL120 Combination":"548063.9940","22 HCC1806 GSK 1 uM":"425101.0207","25 HCC1806 GSK 1 uM":"387480.3433","21 HCC1806 DMM 5 mM":"4015686.6720","24 HCC1806 DMM 5 mM":"4092072.3110","23 HCC1806 Combination":"273113.1165","26 HCC1806 Combination":"270568.9816","34 HS578T GSK 1 uM":"352993.4104","37 HS578T GSK 1 uM":"351496.5733","33 HS578T DMM 5 mM":"477031.8225","36 HS578T DMM 5 mM":"422843.3529","35 HS578T Combination":"214381.6581","38 HS578T Combination":"184197.8078","16 MCF7 GSK 1 uM":"8831420.1330","19 MCF7 GSK 1 uM":"12198921.1000","15 MCF7 DMM 5 mM":"29268713.3000","18 MCF7 DMM 5 mM":"26896719.3800","17 MCF7 Combination":"2529823.7780","20 MCF7 Combination":"1344427.5880","28 MDA-MB-231 GSK 1 uM":"153607.8369","31 MDA-MB-231 GSK 1 uM":"124725.6157","27 MDA-MB-231 DMM 5 mM":"2773345.2960","30 MDA-MB-231 DMM 5 mM":"2754106.4380","29 MDA-MB-231 Combination":"69189.5397","32 MDA-MB-231 Combination":"74048.4042","04 MDA-MB-468 GSK 1 uM":"592935.4599","07 MDA-MB-468 GSK 1 uM":"635430.8860","03 MDA-MB-468 DMM 5 mM":"15440124.4000","06 MDA-MB-468 DMM 5 mM":"14574740.8500","05 MDA-MB-468 Combination":"619498.1783","08 MDA-MB-468 Combination":"739513.8762","01 Blank":"30722.5438","46 Blank":"36619.4219","02 DMEM/F12 no adds":"5714.6103","45 DMEM/F12 no adds":"3433.9209","10 SUM159PT GSK 1 uM":"1290326.9380","13 SUM159PT GSK 1 uM":"1450503.3350","09 SUM159PT DMM 5 mM":"14129197.7500","12 SUM159PT DMM 5 mM":"13978434.2900","11 SUM159PT Combination":"778671.0547","14 SUM159PT Combination":"937009.2892"},{"Metabolite":"O-Caproyl-L-carnitine 85","40 CAL120 GSK 1 uM":"101443.7852","43 CAL120 GSK 1 uM":"91361.8274","39 CAL120 DMM 5 mM":"122398.8534","42 CAL120 DMM 5 mM":"74761.1215","41 CAL120 Combination":"72725.0093","44 CAL120 Combination":"96748.1574","22 HCC1806 GSK 1 uM":"83857.0970","25 HCC1806 GSK 1 uM":"147714.3989","21 HCC1806 DMM 5 mM":"223420.2205","24 HCC1806 DMM 5 mM":"174105.1024","23 HCC1806 Combination":"87282.5916","26 HCC1806 Combination":"66161.8168","34 HS578T GSK 1 uM":"24144.8968","37 HS578T GSK 1 uM":"34627.9122","33 HS578T DMM 5 mM":"28516.1360","36 HS578T DMM 5 mM":"23782.2958","35 HS578T Combination":"32891.4023","38 HS578T Combination":"15497.1151","16 MCF7 GSK 1 uM":"406990.2780","19 MCF7 GSK 1 uM":"484174.9782","15 MCF7 DMM 5 mM":"536956.2778","18 MCF7 DMM 5 mM":"530115.9386","17 MCF7 Combination":"367203.4565","20 MCF7 Combination":"215556.4792","28 MDA-MB-231 GSK 1 uM":"71663.3887","31 MDA-MB-231 GSK 1 uM":"115562.3302","27 MDA-MB-231 DMM 5 mM":"149622.5593","30 MDA-MB-231 DMM 5 mM":"81205.5860","29 MDA-MB-231 Combination":"60379.9823","32 MDA-MB-231 Combination":"95251.8349","04 MDA-MB-468 GSK 1 uM":"243643.2606","07 MDA-MB-468 GSK 1 uM":"474877.1549","03 MDA-MB-468 DMM 5 mM":"572931.9147","06 MDA-MB-468 DMM 5 mM":"526622.3728","05 MDA-MB-468 Combination":"401762.4591","08 MDA-MB-468 Combination":"402594.2297","01 Blank":"343.3887","46 Blank":"1071.0566","02 DMEM/F12 no adds":"6169.0302","45 DMEM/F12 no adds":"7203.6224","10 SUM159PT GSK 1 uM":"221243.7232","13 SUM159PT GSK 1 uM":"238190.5706","09 SUM159PT DMM 5 mM":"193425.8526","12 SUM159PT DMM 5 mM":"326091.6078","11 SUM159PT Combination":"216335.4775","14 SUM159PT Combination":"280129.7000"},{"Metabolite":"O-Capryl-L-carnitine 85","40 CAL120 GSK 1 uM":"23819.3018","43 CAL120 GSK 1 uM":"29973.4062","39 CAL120 DMM 5 mM":"35916.5442","42 CAL120 DMM 5 mM":"33474.3823","41 CAL120 Combination":"11786.3559","44 CAL120 Combination":"24518.6603","22 HCC1806 GSK 1 uM":"13800.1276","25 HCC1806 GSK 1 uM":"21948.5696","21 HCC1806 DMM 5 mM":"19465.6855","24 HCC1806 DMM 5 mM":"24847.8861","23 HCC1806 Combination":"12207.1638","26 HCC1806 Combination":"12454.9656","34 HS578T GSK 1 uM":"10020.2478","37 HS578T GSK 1 uM":"18536.8792","33 HS578T DMM 5 mM":"19753.3160","36 HS578T DMM 5 mM":"19604.1012","35 HS578T Combination":"13034.2204","38 HS578T Combination":"23590.7865","16 MCF7 GSK 1 uM":"31781.0001","19 MCF7 GSK 1 uM":"27920.2103","15 MCF7 DMM 5 mM":"52890.2178","18 MCF7 DMM 5 mM":"72592.1724","17 MCF7 Combination":"21825.0514","20 MCF7 Combination":"15622.3926","28 MDA-MB-231 GSK 1 uM":"15131.8749","31 MDA-MB-231 GSK 1 uM":"21980.8049","27 MDA-MB-231 DMM 5 mM":"26084.3054","30 MDA-MB-231 DMM 5 mM":"33859.0672","29 MDA-MB-231 Combination":"14360.4347","32 MDA-MB-231 Combination":"16029.1048","04 MDA-MB-468 GSK 1 uM":"33843.5669","07 MDA-MB-468 GSK 1 uM":"12624.4070","03 MDA-MB-468 DMM 5 mM":"37238.5108","06 MDA-MB-468 DMM 5 mM":"28822.5708","05 MDA-MB-468 Combination":"13703.3101","08 MDA-MB-468 Combination":"11845.1871","01 Blank":"2512.3699","46 Blank":"2734.6245","02 DMEM/F12 no adds":"7226.3427","45 DMEM/F12 no adds":"14323.1046","10 SUM159PT GSK 1 uM":"22161.8994","13 SUM159PT GSK 1 uM":"18772.8185","09 SUM159PT DMM 5 mM":"44727.5811","12 SUM159PT DMM 5 mM":"44317.7118","11 SUM159PT Combination":"23951.0784","14 SUM159PT Combination":"30821.8884"},{"Metabolite":"O-Caprylyl-L-carnitine 85","40 CAL120 GSK 1 uM":"36217.3600","43 CAL120 GSK 1 uM":"38558.6012","39 CAL120 DMM 5 mM":"78240.0710","42 CAL120 DMM 5 mM":"53322.7380","41 CAL120 Combination":"51239.8710","44 CAL120 Combination":"50298.9819","22 HCC1806 GSK 1 uM":"58447.1070","25 HCC1806 GSK 1 uM":"30113.9875","21 HCC1806 DMM 5 mM":"60308.5715","24 HCC1806 DMM 5 mM":"40737.8924","23 HCC1806 Combination":"45419.4447","26 HCC1806 Combination":"40913.5970","34 HS578T GSK 1 uM":"34778.1359","37 HS578T GSK 1 uM":"16136.9485","33 HS578T DMM 5 mM":"43267.3474","36 HS578T DMM 5 mM":"72727.6815","35 HS578T Combination":"21842.6455","38 HS578T Combination":"48033.5275","16 MCF7 GSK 1 uM":"82728.5041","19 MCF7 GSK 1 uM":"38231.6256","15 MCF7 DMM 5 mM":"61679.4633","18 MCF7 DMM 5 mM":"112677.0170","17 MCF7 Combination":"70841.8880","20 MCF7 Combination":"29995.3035","28 MDA-MB-231 GSK 1 uM":"28779.0962","31 MDA-MB-231 GSK 1 uM":"56072.4565","27 MDA-MB-231 DMM 5 mM":"40764.7435","30 MDA-MB-231 DMM 5 mM":"52846.5087","29 MDA-MB-231 Combination":"78217.4860","32 MDA-MB-231 Combination":"46048.9065","04 MDA-MB-468 GSK 1 uM":"62290.6165","07 MDA-MB-468 GSK 1 uM":"63524.1500","03 MDA-MB-468 DMM 5 mM":"111667.0375","06 MDA-MB-468 DMM 5 mM":"62639.7315","05 MDA-MB-468 Combination":"42264.4105","08 MDA-MB-468 Combination":"29225.7454","01 Blank":"25781.2390","46 Blank":"24928.9188","02 DMEM/F12 no adds":"118712.7915","45 DMEM/F12 no adds":"118698.7380","10 SUM159PT GSK 1 uM":"52701.5385","13 SUM159PT GSK 1 uM":"36644.0749","09 SUM159PT DMM 5 mM":"51250.8973","12 SUM159PT DMM 5 mM":"92052.8405","11 SUM159PT Combination":"64680.4335","14 SUM159PT Combination":"85308.9820"},{"Metabolite":"O-Enanthyl-L-carnitine 85","40 CAL120 GSK 1 uM":"154006.0653","43 CAL120 GSK 1 uM":"127052.6260","39 CAL120 DMM 5 mM":"324509.9659","42 CAL120 DMM 5 mM":"455654.2057","41 CAL120 Combination":"61785.3242","44 CAL120 Combination":"149606.5991","22 HCC1806 GSK 1 uM":"111927.5145","25 HCC1806 GSK 1 uM":"80205.3404","21 HCC1806 DMM 5 mM":"134195.7035","24 HCC1806 DMM 5 mM":"192712.1705","23 HCC1806 Combination":"95421.3239","26 HCC1806 Combination":"76450.1917","34 HS578T GSK 1 uM":"387064.6018","37 HS578T GSK 1 uM":"119955.4525","33 HS578T DMM 5 mM":"93337.1901","36 HS578T DMM 5 mM":"116057.4734","35 HS578T Combination":"238025.5456","38 HS578T Combination":"125130.3439","16 MCF7 GSK 1 uM":"158879.7293","19 MCF7 GSK 1 uM":"64486.6487","15 MCF7 DMM 5 mM":"71207.7890","18 MCF7 DMM 5 mM":"89668.0297","17 MCF7 Combination":"226011.3667","20 MCF7 Combination":"63467.2775","28 MDA-MB-231 GSK 1 uM":"36618.7360","31 MDA-MB-231 GSK 1 uM":"93012.2524","27 MDA-MB-231 DMM 5 mM":"79163.6570","30 MDA-MB-231 DMM 5 mM":"163969.2823","29 MDA-MB-231 Combination":"226576.0848","32 MDA-MB-231 Combination":"73836.3657","04 MDA-MB-468 GSK 1 uM":"94813.5880","07 MDA-MB-468 GSK 1 uM":"170096.3463","03 MDA-MB-468 DMM 5 mM":"427539.6329","06 MDA-MB-468 DMM 5 mM":"147538.3251","05 MDA-MB-468 Combination":"135051.1257","08 MDA-MB-468 Combination":"95290.2148","01 Blank":"280536.7730","46 Blank":"275054.0345","02 DMEM/F12 no adds":"3849.0033","45 DMEM/F12 no adds":"5870.8525","10 SUM159PT GSK 1 uM":"405957.1386","13 SUM159PT GSK 1 uM":"46159.9893","09 SUM159PT DMM 5 mM":"93574.7023","12 SUM159PT DMM 5 mM":"131383.3450","11 SUM159PT Combination":"24612.3943","14 SUM159PT Combination":"120543.9346"},{"Metabolite":"O-Erucioyl-L-carnitine 85","40 CAL120 GSK 1 uM":"58375.8919","43 CAL120 GSK 1 uM":"85567.1562","39 CAL120 DMM 5 mM":"74331.8252","42 CAL120 DMM 5 mM":"78670.2590","41 CAL120 Combination":"64071.5089","44 CAL120 Combination":"67485.6401","22 HCC1806 GSK 1 uM":"59679.6144","25 HCC1806 GSK 1 uM":"66620.3414","21 HCC1806 DMM 5 mM":"104338.1851","24 HCC1806 DMM 5 mM":"92508.9587","23 HCC1806 Combination":"59519.3543","26 HCC1806 Combination":"58411.7605","34 HS578T GSK 1 uM":"52715.9423","37 HS578T GSK 1 uM":"57231.4478","33 HS578T DMM 5 mM":"57987.8069","36 HS578T DMM 5 mM":"55171.3967","35 HS578T Combination":"65658.5411","38 HS578T Combination":"54112.3575","16 MCF7 GSK 1 uM":"69394.5213","19 MCF7 GSK 1 uM":"79596.8193","15 MCF7 DMM 5 mM":"85138.4330","18 MCF7 DMM 5 mM":"97608.8172","17 MCF7 Combination":"77104.5787","20 MCF7 Combination":"53759.8766","28 MDA-MB-231 GSK 1 uM":"90766.2369","31 MDA-MB-231 GSK 1 uM":"84073.4543","27 MDA-MB-231 DMM 5 mM":"182189.8851","30 MDA-MB-231 DMM 5 mM":"188381.0243","29 MDA-MB-231 Combination":"119293.9140","32 MDA-MB-231 Combination":"112222.2712","04 MDA-MB-468 GSK 1 uM":"82005.5695","07 MDA-MB-468 GSK 1 uM":"73876.3460","03 MDA-MB-468 DMM 5 mM":"97077.1557","06 MDA-MB-468 DMM 5 mM":"111329.5289","05 MDA-MB-468 Combination":"80386.6760","08 MDA-MB-468 Combination":"75016.4292","01 Blank":"534.2769","46 Blank":"484.7843","02 DMEM/F12 no adds":"584.4541","45 DMEM/F12 no adds":"1104.9922","10 SUM159PT GSK 1 uM":"44843.8901","13 SUM159PT GSK 1 uM":"55645.0221","09 SUM159PT DMM 5 mM":"40952.2941","12 SUM159PT DMM 5 mM":"52680.8725","11 SUM159PT Combination":"49393.5064","14 SUM159PT Combination":"57074.2219"},{"Metabolite":"O-Formyl-L-carnitine 145","40 CAL120 GSK 1 uM":"8755.3363","43 CAL120 GSK 1 uM":"10951.7436","39 CAL120 DMM 5 mM":"11499.6294","42 CAL120 DMM 5 mM":"9868.6912","41 CAL120 Combination":"11659.2526","44 CAL120 Combination":"11049.1398","22 HCC1806 GSK 1 uM":"28137.2613","25 HCC1806 GSK 1 uM":"33126.7259","21 HCC1806 DMM 5 mM":"42472.9965","24 HCC1806 DMM 5 mM":"39269.5689","23 HCC1806 Combination":"46193.0196","26 HCC1806 Combination":"44233.2248","34 HS578T GSK 1 uM":"14407.2374","37 HS578T GSK 1 uM":"14897.0704","33 HS578T DMM 5 mM":"13071.5351","36 HS578T DMM 5 mM":"11332.7551","35 HS578T Combination":"16250.6873","38 HS578T Combination":"12178.8787","16 MCF7 GSK 1 uM":"13394.2139","19 MCF7 GSK 1 uM":"17284.8327","15 MCF7 DMM 5 mM":"17879.5261","18 MCF7 DMM 5 mM":"20447.4192","17 MCF7 Combination":"17157.2933","20 MCF7 Combination":"10132.6314","28 MDA-MB-231 GSK 1 uM":"14611.2987","31 MDA-MB-231 GSK 1 uM":"11101.4267","27 MDA-MB-231 DMM 5 mM":"10370.0426","30 MDA-MB-231 DMM 5 mM":"11666.5253","29 MDA-MB-231 Combination":"10662.9156","32 MDA-MB-231 Combination":"13042.0992","04 MDA-MB-468 GSK 1 uM":"20302.9993","07 MDA-MB-468 GSK 1 uM":"23622.5951","03 MDA-MB-468 DMM 5 mM":"25164.6094","06 MDA-MB-468 DMM 5 mM":"23194.8131","05 MDA-MB-468 Combination":"21860.5162","08 MDA-MB-468 Combination":"25449.7091","01 Blank":"1415.9690","46 Blank":"822.7418","02 DMEM/F12 no adds":"53698.4448","45 DMEM/F12 no adds":"60233.2801","10 SUM159PT GSK 1 uM":"714.8436","13 SUM159PT GSK 1 uM":"3778.0270","09 SUM159PT DMM 5 mM":"1384.1443","12 SUM159PT DMM 5 mM":"3552.2438","11 SUM159PT Combination":"4313.7513","14 SUM159PT Combination":"6862.4928"},{"Metabolite":"O-Lauroleoyl-L-carnitine 85","40 CAL120 GSK 1 uM":"8991.4937","43 CAL120 GSK 1 uM":"9812.0827","39 CAL120 DMM 5 mM":"20210.5913","42 CAL120 DMM 5 mM":"16764.6850","41 CAL120 Combination":"12440.7120","44 CAL120 Combination":"8508.9269","22 HCC1806 GSK 1 uM":"5310.4157","25 HCC1806 GSK 1 uM":"6870.5240","21 HCC1806 DMM 5 mM":"9789.1924","24 HCC1806 DMM 5 mM":"7162.1296","23 HCC1806 Combination":"5547.6247","26 HCC1806 Combination":"5300.0972","34 HS578T GSK 1 uM":"4723.7829","37 HS578T GSK 1 uM":"8806.9562","33 HS578T DMM 5 mM":"7974.5912","36 HS578T DMM 5 mM":"4087.7714","35 HS578T Combination":"7461.3669","38 HS578T Combination":"2139.5349","16 MCF7 GSK 1 uM":"13446.0507","19 MCF7 GSK 1 uM":"11960.4232","15 MCF7 DMM 5 mM":"49417.8557","18 MCF7 DMM 5 mM":"44494.0771","17 MCF7 Combination":"17712.6846","20 MCF7 Combination":"10556.0719","28 MDA-MB-231 GSK 1 uM":"5461.1638","31 MDA-MB-231 GSK 1 uM":"8614.2617","27 MDA-MB-231 DMM 5 mM":"16686.7038","30 MDA-MB-231 DMM 5 mM":"7624.0653","29 MDA-MB-231 Combination":"2481.9172","32 MDA-MB-231 Combination":"7780.1468","04 MDA-MB-468 GSK 1 uM":"12187.6324","07 MDA-MB-468 GSK 1 uM":"6635.9079","03 MDA-MB-468 DMM 5 mM":"12126.8533","06 MDA-MB-468 DMM 5 mM":"13193.0142","05 MDA-MB-468 Combination":"11815.6005","08 MDA-MB-468 Combination":"4091.8773","01 Blank":"1449.6196","46 Blank":"1989.7643","02 DMEM/F12 no adds":"3225.5541","45 DMEM/F12 no adds":"2429.6015","10 SUM159PT GSK 1 uM":"13061.6708","13 SUM159PT GSK 1 uM":"8257.9028","09 SUM159PT DMM 5 mM":"23383.2678","12 SUM159PT DMM 5 mM":"31602.6986","11 SUM159PT Combination":"11774.3551","14 SUM159PT Combination":"10246.0438"},{"Metabolite":"O-Lauroyl-L-carnitine 85","40 CAL120 GSK 1 uM":"15974.2035","43 CAL120 GSK 1 uM":"16445.3184","39 CAL120 DMM 5 mM":"91748.1450","42 CAL120 DMM 5 mM":"75704.8446","41 CAL120 Combination":"17652.8826","44 CAL120 Combination":"20532.1083","22 HCC1806 GSK 1 uM":"1690.7917","25 HCC1806 GSK 1 uM":"3809.5112","21 HCC1806 DMM 5 mM":"10671.6462","24 HCC1806 DMM 5 mM":"13493.9824","23 HCC1806 Combination":"3389.2601","26 HCC1806 Combination":"5795.7615","34 HS578T GSK 1 uM":"7580.0738","37 HS578T GSK 1 uM":"10586.3057","33 HS578T DMM 5 mM":"8395.1078","36 HS578T DMM 5 mM":"10841.3005","35 HS578T Combination":"9361.2212","38 HS578T Combination":"9182.2251","16 MCF7 GSK 1 uM":"11405.7204","19 MCF7 GSK 1 uM":"13181.3539","15 MCF7 DMM 5 mM":"169110.6345","18 MCF7 DMM 5 mM":"188627.0210","17 MCF7 Combination":"11801.6872","20 MCF7 Combination":"11167.0449","28 MDA-MB-231 GSK 1 uM":"10066.6914","31 MDA-MB-231 GSK 1 uM":"7419.9097","27 MDA-MB-231 DMM 5 mM":"17502.4582","30 MDA-MB-231 DMM 5 mM":"12435.3665","29 MDA-MB-231 Combination":"8433.3357","32 MDA-MB-231 Combination":"10189.5392","04 MDA-MB-468 GSK 1 uM":"8890.6641","07 MDA-MB-468 GSK 1 uM":"8159.8209","03 MDA-MB-468 DMM 5 mM":"30665.4163","06 MDA-MB-468 DMM 5 mM":"31804.0067","05 MDA-MB-468 Combination":"10681.3025","08 MDA-MB-468 Combination":"9492.2956","01 Blank":"1936.0041","46 Blank":"1734.4072","02 DMEM/F12 no adds":"880.7939","45 DMEM/F12 no adds":"1876.4023","10 SUM159PT GSK 1 uM":"7522.2408","13 SUM159PT GSK 1 uM":"10750.6853","09 SUM159PT DMM 5 mM":"86997.2440","12 SUM159PT DMM 5 mM":"86000.7382","11 SUM159PT Combination":"11691.9566","14 SUM159PT Combination":"12283.1364"},{"Metabolite":"O-Margaroyl-L-carnitine 85","40 CAL120 GSK 1 uM":"45885.1380","43 CAL120 GSK 1 uM":"42290.2414","39 CAL120 DMM 5 mM":"52192.9730","42 CAL120 DMM 5 mM":"56388.6202","41 CAL120 Combination":"44289.7149","44 CAL120 Combination":"40882.3775","22 HCC1806 GSK 1 uM":"14783.7861","25 HCC1806 GSK 1 uM":"8031.2087","21 HCC1806 DMM 5 mM":"32618.5380","24 HCC1806 DMM 5 mM":"15350.7056","23 HCC1806 Combination":"9176.0421","26 HCC1806 Combination":"10958.6681","34 HS578T GSK 1 uM":"47001.0953","37 HS578T GSK 1 uM":"32162.5948","33 HS578T DMM 5 mM":"43828.1263","36 HS578T DMM 5 mM":"2219.9245","35 HS578T Combination":"44135.6657","38 HS578T Combination":"26756.9893","16 MCF7 GSK 1 uM":"18713.0307","19 MCF7 GSK 1 uM":"32011.7657","15 MCF7 DMM 5 mM":"42723.8686","18 MCF7 DMM 5 mM":"45535.5213","17 MCF7 Combination":"9740.7594","20 MCF7 Combination":"20501.3053","28 MDA-MB-231 GSK 1 uM":"22706.5411","31 MDA-MB-231 GSK 1 uM":"15887.9722","27 MDA-MB-231 DMM 5 mM":"29305.8958","30 MDA-MB-231 DMM 5 mM":"15026.4803","29 MDA-MB-231 Combination":"3183.3981","32 MDA-MB-231 Combination":"22130.7689","04 MDA-MB-468 GSK 1 uM":"16552.9609","07 MDA-MB-468 GSK 1 uM":"12969.5626","03 MDA-MB-468 DMM 5 mM":"12756.3559","06 MDA-MB-468 DMM 5 mM":"13837.8014","05 MDA-MB-468 Combination":"6854.8992","08 MDA-MB-468 Combination":"6963.2805","01 Blank":"1054.4733","46 Blank":"463.4887","02 DMEM/F12 no adds":"1311.5557","45 DMEM/F12 no adds":"492.0838","10 SUM159PT GSK 1 uM":"8024.1350","13 SUM159PT GSK 1 uM":"5871.2471","09 SUM159PT DMM 5 mM":"23223.3996","12 SUM159PT DMM 5 mM":"18409.2884","11 SUM159PT Combination":"13150.6423","14 SUM159PT Combination":"9391.1267"},{"Metabolite":"O-Myristoleoyl-L-carnitine 85","40 CAL120 GSK 1 uM":"62790.8017","43 CAL120 GSK 1 uM":"88580.4899","39 CAL120 DMM 5 mM":"125735.9638","42 CAL120 DMM 5 mM":"144783.8322","41 CAL120 Combination":"69377.7365","44 CAL120 Combination":"80056.5109","22 HCC1806 GSK 1 uM":"25140.2458","25 HCC1806 GSK 1 uM":"23571.1725","21 HCC1806 DMM 5 mM":"19375.6441","24 HCC1806 DMM 5 mM":"19659.7201","23 HCC1806 Combination":"15161.0522","26 HCC1806 Combination":"9968.8947","34 HS578T GSK 1 uM":"20486.4089","37 HS578T GSK 1 uM":"22421.3291","33 HS578T DMM 5 mM":"21377.6514","36 HS578T DMM 5 mM":"39505.9279","35 HS578T Combination":"25109.4461","38 HS578T Combination":"45120.5592","16 MCF7 GSK 1 uM":"43202.5458","19 MCF7 GSK 1 uM":"40583.0576","15 MCF7 DMM 5 mM":"318689.5677","18 MCF7 DMM 5 mM":"277335.9999","17 MCF7 Combination":"37862.5561","20 MCF7 Combination":"24980.6951","28 MDA-MB-231 GSK 1 uM":"28891.0704","31 MDA-MB-231 GSK 1 uM":"32008.6520","27 MDA-MB-231 DMM 5 mM":"44620.5103","30 MDA-MB-231 DMM 5 mM":"25744.9915","29 MDA-MB-231 Combination":"32552.8428","32 MDA-MB-231 Combination":"28946.5106","04 MDA-MB-468 GSK 1 uM":"26384.2391","07 MDA-MB-468 GSK 1 uM":"21581.1588","03 MDA-MB-468 DMM 5 mM":"23534.6774","06 MDA-MB-468 DMM 5 mM":"29858.3938","05 MDA-MB-468 Combination":"13963.3540","08 MDA-MB-468 Combination":"20163.3901","01 Blank":"1486.3499","46 Blank":"256.7760","02 DMEM/F12 no adds":"4089.5094","45 DMEM/F12 no adds":"5283.3033","10 SUM159PT GSK 1 uM":"16855.0298","13 SUM159PT GSK 1 uM":"18593.4040","09 SUM159PT DMM 5 mM":"116228.7780","12 SUM159PT DMM 5 mM":"117241.3341","11 SUM159PT Combination":"33109.9223","14 SUM159PT Combination":"52235.7723"},{"Metabolite":"O-Myristoyl-L-carnitine 85","40 CAL120 GSK 1 uM":"87947.3331","43 CAL120 GSK 1 uM":"81115.9240","39 CAL120 DMM 5 mM":"341682.2711","42 CAL120 DMM 5 mM":"321629.0431","41 CAL120 Combination":"91477.8338","44 CAL120 Combination":"95755.2775","22 HCC1806 GSK 1 uM":"13110.8069","25 HCC1806 GSK 1 uM":"15750.7527","21 HCC1806 DMM 5 mM":"208903.5801","24 HCC1806 DMM 5 mM":"273995.7665","23 HCC1806 Combination":"10655.1909","26 HCC1806 Combination":"17060.9266","34 HS578T GSK 1 uM":"68769.3853","37 HS578T GSK 1 uM":"71255.4983","33 HS578T DMM 5 mM":"68475.9285","36 HS578T DMM 5 mM":"64093.0023","35 HS578T Combination":"59590.0381","38 HS578T Combination":"55474.5225","16 MCF7 GSK 1 uM":"49160.7190","19 MCF7 GSK 1 uM":"61094.1673","15 MCF7 DMM 5 mM":"1358966.7780","18 MCF7 DMM 5 mM":"1092130.3300","17 MCF7 Combination":"51682.2829","20 MCF7 Combination":"44313.5507","28 MDA-MB-231 GSK 1 uM":"30724.1494","31 MDA-MB-231 GSK 1 uM":"33164.0194","27 MDA-MB-231 DMM 5 mM":"53381.1837","30 MDA-MB-231 DMM 5 mM":"51678.1613","29 MDA-MB-231 Combination":"41862.6100","32 MDA-MB-231 Combination":"52307.7700","04 MDA-MB-468 GSK 1 uM":"38821.7540","07 MDA-MB-468 GSK 1 uM":"31720.3226","03 MDA-MB-468 DMM 5 mM":"74959.5773","06 MDA-MB-468 DMM 5 mM":"69183.0268","05 MDA-MB-468 Combination":"31742.7620","08 MDA-MB-468 Combination":"40098.7316","01 Blank":"1622.1171","46 Blank":"1129.1110","02 DMEM/F12 no adds":"2028.9334","45 DMEM/F12 no adds":"2342.3740","10 SUM159PT GSK 1 uM":"12579.6408","13 SUM159PT GSK 1 uM":"14037.9573","09 SUM159PT DMM 5 mM":"173870.7339","12 SUM159PT DMM 5 mM":"203620.7686","11 SUM159PT Combination":"15120.7135","14 SUM159PT Combination":"19472.5779"},{"Metabolite":"O-Oleoyl-L-carnitine 85","40 CAL120 GSK 1 uM":"458154.6350","43 CAL120 GSK 1 uM":"525753.0854","39 CAL120 DMM 5 mM":"992290.9199","42 CAL120 DMM 5 mM":"956673.5087","41 CAL120 Combination":"412252.8363","44 CAL120 Combination":"404240.6437","22 HCC1806 GSK 1 uM":"24324.1501","25 HCC1806 GSK 1 uM":"5129.5006","21 HCC1806 DMM 5 mM":"161435.1853","24 HCC1806 DMM 5 mM":"187747.1517","23 HCC1806 Combination":"10925.6431","26 HCC1806 Combination":"15606.6904","34 HS578T GSK 1 uM":"172355.6912","37 HS578T GSK 1 uM":"173869.6892","33 HS578T DMM 5 mM":"152136.1174","36 HS578T DMM 5 mM":"172528.0754","35 HS578T Combination":"189711.5166","38 HS578T Combination":"160647.8781","16 MCF7 GSK 1 uM":"575587.8566","19 MCF7 GSK 1 uM":"686955.3259","15 MCF7 DMM 5 mM":"1475448.3340","18 MCF7 DMM 5 mM":"1315385.2140","17 MCF7 Combination":"310925.4244","20 MCF7 Combination":"227893.9482","28 MDA-MB-231 GSK 1 uM":"61384.4161","31 MDA-MB-231 GSK 1 uM":"58113.6383","27 MDA-MB-231 DMM 5 mM":"87038.3787","30 MDA-MB-231 DMM 5 mM":"78120.0546","29 MDA-MB-231 Combination":"61056.1895","32 MDA-MB-231 Combination":"65813.2209","04 MDA-MB-468 GSK 1 uM":"26957.6057","07 MDA-MB-468 GSK 1 uM":"38407.3126","03 MDA-MB-468 DMM 5 mM":"52516.9416","06 MDA-MB-468 DMM 5 mM":"58781.4523","05 MDA-MB-468 Combination":"28966.6781","08 MDA-MB-468 Combination":"41140.1690","01 Blank":"514.5647","46 Blank":"718.2248","02 DMEM/F12 no adds":"1063.2697","45 DMEM/F12 no adds":"1161.4366","10 SUM159PT GSK 1 uM":"42775.9159","13 SUM159PT GSK 1 uM":"44264.3908","09 SUM159PT DMM 5 mM":"251665.8128","12 SUM159PT DMM 5 mM":"289723.9417","11 SUM159PT Combination":"39244.4075","14 SUM159PT Combination":"52042.5308"},{"Metabolite":"O-Palmitoleoyl-L-carnitine 85","40 CAL120 GSK 1 uM":"80439.7036","43 CAL120 GSK 1 uM":"86745.4584","39 CAL120 DMM 5 mM":"225901.6381","42 CAL120 DMM 5 mM":"186411.4351","41 CAL120 Combination":"78003.6536","44 CAL120 Combination":"67558.5609","22 HCC1806 GSK 1 uM":"4143.3141","25 HCC1806 GSK 1 uM":"5212.1721","21 HCC1806 DMM 5 mM":"58684.8906","24 HCC1806 DMM 5 mM":"62023.3254","23 HCC1806 Combination":"10787.1416","26 HCC1806 Combination":"6297.5561","34 HS578T GSK 1 uM":"38086.8610","37 HS578T GSK 1 uM":"37759.6707","33 HS578T DMM 5 mM":"37348.2235","36 HS578T DMM 5 mM":"34200.4908","35 HS578T Combination":"37473.9591","38 HS578T Combination":"33459.6909","16 MCF7 GSK 1 uM":"91164.1940","19 MCF7 GSK 1 uM":"125775.7993","15 MCF7 DMM 5 mM":"899165.1948","18 MCF7 DMM 5 mM":"778733.4204","17 MCF7 Combination":"59562.4350","20 MCF7 Combination":"41795.8628","28 MDA-MB-231 GSK 1 uM":"7372.4236","31 MDA-MB-231 GSK 1 uM":"15539.1097","27 MDA-MB-231 DMM 5 mM":"19382.0359","30 MDA-MB-231 DMM 5 mM":"16720.5385","29 MDA-MB-231 Combination":"20369.0165","32 MDA-MB-231 Combination":"15080.8248","04 MDA-MB-468 GSK 1 uM":"15689.1404","07 MDA-MB-468 GSK 1 uM":"10248.3880","03 MDA-MB-468 DMM 5 mM":"34890.8903","06 MDA-MB-468 DMM 5 mM":"37316.0879","05 MDA-MB-468 Combination":"12166.3052","08 MDA-MB-468 Combination":"14216.0367","01 Blank":"1105.4567","46 Blank":"538.8786","02 DMEM/F12 no adds":"1026.9477","45 DMEM/F12 no adds":"725.9721","10 SUM159PT GSK 1 uM":"5203.5180","13 SUM159PT GSK 1 uM":"6311.4656","09 SUM159PT DMM 5 mM":"73496.8479","12 SUM159PT DMM 5 mM":"78987.5619","11 SUM159PT Combination":"16389.2848","14 SUM159PT Combination":"12456.6264"},{"Metabolite":"O-Palmitoyl-L-carnitine 85","40 CAL120 GSK 1 uM":"371998.9589","43 CAL120 GSK 1 uM":"419203.3408","39 CAL120 DMM 5 mM":"868475.1103","42 CAL120 DMM 5 mM":"879657.2735","41 CAL120 Combination":"381439.3513","44 CAL120 Combination":"313224.0655","22 HCC1806 GSK 1 uM":"29300.1640","25 HCC1806 GSK 1 uM":"25734.7762","21 HCC1806 DMM 5 mM":"611152.4579","24 HCC1806 DMM 5 mM":"682061.0895","23 HCC1806 Combination":"27145.3782","26 HCC1806 Combination":"19805.9037","34 HS578T GSK 1 uM":"243951.5526","37 HS578T GSK 1 uM":"253350.7850","33 HS578T DMM 5 mM":"262360.4951","36 HS578T DMM 5 mM":"267427.0655","35 HS578T Combination":"247272.4018","38 HS578T Combination":"240084.7551","16 MCF7 GSK 1 uM":"247869.6016","19 MCF7 GSK 1 uM":"255088.3057","15 MCF7 DMM 5 mM":"2026769.5970","18 MCF7 DMM 5 mM":"1820522.2350","17 MCF7 Combination":"191311.8271","20 MCF7 Combination":"144021.8035","28 MDA-MB-231 GSK 1 uM":"86958.0884","31 MDA-MB-231 GSK 1 uM":"108096.9292","27 MDA-MB-231 DMM 5 mM":"158564.4127","30 MDA-MB-231 DMM 5 mM":"135084.3554","29 MDA-MB-231 Combination":"124285.0983","32 MDA-MB-231 Combination":"106201.4444","04 MDA-MB-468 GSK 1 uM":"69259.1143","07 MDA-MB-468 GSK 1 uM":"72833.0742","03 MDA-MB-468 DMM 5 mM":"110295.6841","06 MDA-MB-468 DMM 5 mM":"112458.8881","05 MDA-MB-468 Combination":"64256.3467","08 MDA-MB-468 Combination":"61428.1854","01 Blank":"743.2386","46 Blank":"1337.4232","02 DMEM/F12 no adds":"1336.0417","45 DMEM/F12 no adds":"1408.9701","10 SUM159PT GSK 1 uM":"31132.6496","13 SUM159PT GSK 1 uM":"25509.0950","09 SUM159PT DMM 5 mM":"152264.0744","12 SUM159PT DMM 5 mM":"153237.0805","11 SUM159PT Combination":"9562.0770","14 SUM159PT Combination":"27039.2926"},{"Metabolite":"O-Paullinoyl-L-carnitine 85","40 CAL120 GSK 1 uM":"62199.5357","43 CAL120 GSK 1 uM":"80908.2281","39 CAL120 DMM 5 mM":"60263.1940","42 CAL120 DMM 5 mM":"82409.0386","41 CAL120 Combination":"76877.7131","44 CAL120 Combination":"94259.8904","22 HCC1806 GSK 1 uM":"11219.5366","25 HCC1806 GSK 1 uM":"13503.6894","21 HCC1806 DMM 5 mM":"19212.1208","24 HCC1806 DMM 5 mM":"19449.4734","23 HCC1806 Combination":"14934.9986","26 HCC1806 Combination":"12565.2748","34 HS578T GSK 1 uM":"42256.9577","37 HS578T GSK 1 uM":"35603.5311","33 HS578T DMM 5 mM":"36554.3895","36 HS578T DMM 5 mM":"20689.2212","35 HS578T Combination":"58174.1560","38 HS578T Combination":"47249.8118","16 MCF7 GSK 1 uM":"86352.4780","19 MCF7 GSK 1 uM":"98847.3215","15 MCF7 DMM 5 mM":"121955.4563","18 MCF7 DMM 5 mM":"107262.3582","17 MCF7 Combination":"27265.8821","20 MCF7 Combination":"50098.5872","28 MDA-MB-231 GSK 1 uM":"19292.9214","31 MDA-MB-231 GSK 1 uM":"17074.8049","27 MDA-MB-231 DMM 5 mM":"24508.5628","30 MDA-MB-231 DMM 5 mM":"29875.5017","29 MDA-MB-231 Combination":"17473.4750","32 MDA-MB-231 Combination":"16172.8833","04 MDA-MB-468 GSK 1 uM":"32527.9203","07 MDA-MB-468 GSK 1 uM":"42671.0944","03 MDA-MB-468 DMM 5 mM":"37503.9232","06 MDA-MB-468 DMM 5 mM":"47061.2621","05 MDA-MB-468 Combination":"32985.2263","08 MDA-MB-468 Combination":"41034.8013","01 Blank":"317.1096","46 Blank":"495.4920","02 DMEM/F12 no adds":"559.5024","45 DMEM/F12 no adds":"756.5240","10 SUM159PT GSK 1 uM":"15290.6775","13 SUM159PT GSK 1 uM":"26602.7408","09 SUM159PT DMM 5 mM":"16930.1371","12 SUM159PT DMM 5 mM":"20955.3822","11 SUM159PT Combination":"21972.4985","14 SUM159PT Combination":"22982.0554"},{"Metabolite":"O-Pelargonyl-L-carnitine 85","40 CAL120 GSK 1 uM":"3879.8380","43 CAL120 GSK 1 uM":"5577.2189","39 CAL120 DMM 5 mM":"6341.1778","42 CAL120 DMM 5 mM":"6829.2052","41 CAL120 Combination":"4026.1116","44 CAL120 Combination":"7788.1725","22 HCC1806 GSK 1 uM":"4809.0850","25 HCC1806 GSK 1 uM":"4446.4298","21 HCC1806 DMM 5 mM":"4815.5796","24 HCC1806 DMM 5 mM":"4951.3141","23 HCC1806 Combination":"6079.2723","26 HCC1806 Combination":"3385.7268","34 HS578T GSK 1 uM":"6411.8091","37 HS578T GSK 1 uM":"6249.3292","33 HS578T DMM 5 mM":"8348.9634","36 HS578T DMM 5 mM":"3888.8958","35 HS578T Combination":"11483.1782","38 HS578T Combination":"18248.7120","16 MCF7 GSK 1 uM":"15542.4158","19 MCF7 GSK 1 uM":"18395.8736","15 MCF7 DMM 5 mM":"7026.8572","18 MCF7 DMM 5 mM":"7433.3111","17 MCF7 Combination":"9197.9801","20 MCF7 Combination":"13006.6451","28 MDA-MB-231 GSK 1 uM":"4795.6728","31 MDA-MB-231 GSK 1 uM":"9187.6272","27 MDA-MB-231 DMM 5 mM":"5713.8446","30 MDA-MB-231 DMM 5 mM":"12753.2255","29 MDA-MB-231 Combination":"14746.3615","32 MDA-MB-231 Combination":"1986.6477","04 MDA-MB-468 GSK 1 uM":"14511.5920","07 MDA-MB-468 GSK 1 uM":"14404.2988","03 MDA-MB-468 DMM 5 mM":"9788.7475","06 MDA-MB-468 DMM 5 mM":"9203.9885","05 MDA-MB-468 Combination":"10010.0036","08 MDA-MB-468 Combination":"17136.1611","01 Blank":"2668.1663","46 Blank":"1487.9090","02 DMEM/F12 no adds":"8523.9125","45 DMEM/F12 no adds":"16198.5601","10 SUM159PT GSK 1 uM":"14982.8635","13 SUM159PT GSK 1 uM":"11369.3511","09 SUM159PT DMM 5 mM":"9692.0780","12 SUM159PT DMM 5 mM":"11804.6647","11 SUM159PT Combination":"8934.0127","14 SUM159PT Combination":"14941.2263"},{"Metabolite":"O-Pentadecyloyl-L-carnitine 85","40 CAL120 GSK 1 uM":"23516.7520","43 CAL120 GSK 1 uM":"24034.1157","39 CAL120 DMM 5 mM":"41570.2838","42 CAL120 DMM 5 mM":"38897.6335","41 CAL120 Combination":"21677.5532","44 CAL120 Combination":"25546.2852","22 HCC1806 GSK 1 uM":"13858.5316","25 HCC1806 GSK 1 uM":"5949.2983","21 HCC1806 DMM 5 mM":"30614.5848","24 HCC1806 DMM 5 mM":"26238.6844","23 HCC1806 Combination":"14246.1726","26 HCC1806 Combination":"11637.4340","34 HS578T GSK 1 uM":"26727.2902","37 HS578T GSK 1 uM":"20792.8275","33 HS578T DMM 5 mM":"24184.1273","36 HS578T DMM 5 mM":"27929.1874","35 HS578T Combination":"30726.1430","38 HS578T Combination":"32931.0011","16 MCF7 GSK 1 uM":"18695.9112","19 MCF7 GSK 1 uM":"14928.0947","15 MCF7 DMM 5 mM":"38280.8458","18 MCF7 DMM 5 mM":"32928.0590","17 MCF7 Combination":"12999.7148","20 MCF7 Combination":"10080.3209","28 MDA-MB-231 GSK 1 uM":"16200.6460","31 MDA-MB-231 GSK 1 uM":"15138.3864","27 MDA-MB-231 DMM 5 mM":"20724.8827","30 MDA-MB-231 DMM 5 mM":"25849.8634","29 MDA-MB-231 Combination":"20874.3787","32 MDA-MB-231 Combination":"19358.0612","04 MDA-MB-468 GSK 1 uM":"16802.1872","07 MDA-MB-468 GSK 1 uM":"15669.4705","03 MDA-MB-468 DMM 5 mM":"32890.1962","06 MDA-MB-468 DMM 5 mM":"21657.2992","05 MDA-MB-468 Combination":"16424.6906","08 MDA-MB-468 Combination":"15628.7718","01 Blank":"910.2063","46 Blank":"1568.9623","02 DMEM/F12 no adds":"543.1757","45 DMEM/F12 no adds":"868.6093","10 SUM159PT GSK 1 uM":"12786.7142","13 SUM159PT GSK 1 uM":"11439.0989","09 SUM159PT DMM 5 mM":"31643.0414","12 SUM159PT DMM 5 mM":"25558.4215","11 SUM159PT Combination":"13206.9450","14 SUM159PT Combination":"10473.5825"},{"Metabolite":"O-Propionyl-L-carnitine 85","40 CAL120 GSK 1 uM":"23238128.1800","43 CAL120 GSK 1 uM":"24648285.4000","39 CAL120 DMM 5 mM":"15592306.1500","42 CAL120 DMM 5 mM":"14175732.8100","41 CAL120 Combination":"15456119.0700","44 CAL120 Combination":"15181195.5700","22 HCC1806 GSK 1 uM":"10559372.8200","25 HCC1806 GSK 1 uM":"10046211.5900","21 HCC1806 DMM 5 mM":"2552644.7080","24 HCC1806 DMM 5 mM":"2532306.6120","23 HCC1806 Combination":"3884768.5270","26 HCC1806 Combination":"3915628.6500","34 HS578T GSK 1 uM":"1248014.2890","37 HS578T GSK 1 uM":"1226515.0480","33 HS578T DMM 5 mM":"534136.7729","36 HS578T DMM 5 mM":"448808.7791","35 HS578T Combination":"606114.9796","38 HS578T Combination":"481124.3512","16 MCF7 GSK 1 uM":"23081216.3400","19 MCF7 GSK 1 uM":"28872357.7500","15 MCF7 DMM 5 mM":"6703514.4410","18 MCF7 DMM 5 mM":"6439128.8000","17 MCF7 Combination":"13270907.5700","20 MCF7 Combination":"7743415.5040","28 MDA-MB-231 GSK 1 uM":"13367624.1500","31 MDA-MB-231 GSK 1 uM":"15452051.0500","27 MDA-MB-231 DMM 5 mM":"6418389.4020","30 MDA-MB-231 DMM 5 mM":"6087987.6130","29 MDA-MB-231 Combination":"5846737.0970","32 MDA-MB-231 Combination":"6980262.0320","04 MDA-MB-468 GSK 1 uM":"25283409.3500","07 MDA-MB-468 GSK 1 uM":"26586601.6900","03 MDA-MB-468 DMM 5 mM":"13158229.2700","06 MDA-MB-468 DMM 5 mM":"12468017.8100","05 MDA-MB-468 Combination":"18505593.5300","08 MDA-MB-468 Combination":"17800432.4700","01 Blank":"2101.6468","46 Blank":"2430.9282","02 DMEM/F12 no adds":"5941.3518","45 DMEM/F12 no adds":"2948.7456","10 SUM159PT GSK 1 uM":"12188966.4800","13 SUM159PT GSK 1 uM":"14409013.7600","09 SUM159PT DMM 5 mM":"7172794.5980","12 SUM159PT DMM 5 mM":"7284744.5500","11 SUM159PT Combination":"8309255.9220","14 SUM159PT Combination":"10024228.0500"},{"Metabolite":"Ornithine 70","40 CAL120 GSK 1 uM":"1534751.0580","43 CAL120 GSK 1 uM":"1548553.6890","39 CAL120 DMM 5 mM":"2139768.2290","42 CAL120 DMM 5 mM":"1385767.5330","41 CAL120 Combination":"1388831.1270","44 CAL120 Combination":"1087683.5990","22 HCC1806 GSK 1 uM":"4158368.7350","25 HCC1806 GSK 1 uM":"4075975.1680","21 HCC1806 DMM 5 mM":"5276432.7790","24 HCC1806 DMM 5 mM":"4155935.3870","23 HCC1806 Combination":"3761190.8710","26 HCC1806 Combination":"4212658.4940","34 HS578T GSK 1 uM":"1031246.2870","37 HS578T GSK 1 uM":"1551163.7730","33 HS578T DMM 5 mM":"1180431.7330","36 HS578T DMM 5 mM":"901116.8985","35 HS578T Combination":"1262015.9990","38 HS578T Combination":"876606.2251","16 MCF7 GSK 1 uM":"2016641.2330","19 MCF7 GSK 1 uM":"2235872.2180","15 MCF7 DMM 5 mM":"2628025.4670","18 MCF7 DMM 5 mM":"3437332.8950","17 MCF7 Combination":"2208330.1470","20 MCF7 Combination":"1328832.0210","28 MDA-MB-231 GSK 1 uM":"2675638.6960","31 MDA-MB-231 GSK 1 uM":"2605366.7720","27 MDA-MB-231 DMM 5 mM":"2474678.5330","30 MDA-MB-231 DMM 5 mM":"2860547.2390","29 MDA-MB-231 Combination":"2246671.6560","32 MDA-MB-231 Combination":"2058095.2620","04 MDA-MB-468 GSK 1 uM":"10067083.5600","07 MDA-MB-468 GSK 1 uM":"12137026.2300","03 MDA-MB-468 DMM 5 mM":"11432811.8000","06 MDA-MB-468 DMM 5 mM":"10995676.1600","05 MDA-MB-468 Combination":"8235642.6980","08 MDA-MB-468 Combination":"12083882.4400","01 Blank":"14995.3852","46 Blank":"12025.2686","02 DMEM/F12 no adds":"13863.6646","45 DMEM/F12 no adds":"38140.7540","10 SUM159PT GSK 1 uM":"3284531.9000","13 SUM159PT GSK 1 uM":"4373462.5060","09 SUM159PT DMM 5 mM":"2574579.3810","12 SUM159PT DMM 5 mM":"2484160.6040","11 SUM159PT Combination":"2719351.0740","14 SUM159PT Combination":"3005942.0630"},{"Metabolite":"O-Stearoyl-L-carnitine 85","40 CAL120 GSK 1 uM":"211371.3008","43 CAL120 GSK 1 uM":"195123.0878","39 CAL120 DMM 5 mM":"322228.7130","42 CAL120 DMM 5 mM":"317509.1686","41 CAL120 Combination":"211295.2378","44 CAL120 Combination":"168990.8275","22 HCC1806 GSK 1 uM":"29890.6849","25 HCC1806 GSK 1 uM":"16371.9852","21 HCC1806 DMM 5 mM":"79090.1336","24 HCC1806 DMM 5 mM":"78461.7085","23 HCC1806 Combination":"8492.7007","26 HCC1806 Combination":"14333.0763","34 HS578T GSK 1 uM":"219071.3512","37 HS578T GSK 1 uM":"225637.6763","33 HS578T DMM 5 mM":"198276.7828","36 HS578T DMM 5 mM":"162864.7307","35 HS578T Combination":"230703.0428","38 HS578T Combination":"174973.2813","16 MCF7 GSK 1 uM":"220089.8538","19 MCF7 GSK 1 uM":"303418.2813","15 MCF7 DMM 5 mM":"346329.7050","18 MCF7 DMM 5 mM":"330949.4992","17 MCF7 Combination":"183519.8580","20 MCF7 Combination":"154598.8305","28 MDA-MB-231 GSK 1 uM":"142695.8043","31 MDA-MB-231 GSK 1 uM":"153336.7679","27 MDA-MB-231 DMM 5 mM":"203108.5743","30 MDA-MB-231 DMM 5 mM":"171106.4625","29 MDA-MB-231 Combination":"159755.5313","32 MDA-MB-231 Combination":"141976.6674","04 MDA-MB-468 GSK 1 uM":"71819.5574","07 MDA-MB-468 GSK 1 uM":"68148.5741","03 MDA-MB-468 DMM 5 mM":"36399.4354","06 MDA-MB-468 DMM 5 mM":"76661.5895","05 MDA-MB-468 Combination":"59173.4860","08 MDA-MB-468 Combination":"61170.3395","01 Blank":"704.4458","46 Blank":"825.9970","02 DMEM/F12 no adds":"607.9106","45 DMEM/F12 no adds":"419.0469","10 SUM159PT GSK 1 uM":"23881.3522","13 SUM159PT GSK 1 uM":"24425.4341","09 SUM159PT DMM 5 mM":"52059.5638","12 SUM159PT DMM 5 mM":"57090.6497","11 SUM159PT Combination":"26193.9243","14 SUM159PT Combination":"30730.2000"},{"Metabolite":"O-Tridecyloyl-L-carnitine 85","40 CAL120 GSK 1 uM":"11585.9965","43 CAL120 GSK 1 uM":"12563.0083","39 CAL120 DMM 5 mM":"21273.8933","42 CAL120 DMM 5 mM":"18773.4275","41 CAL120 Combination":"11164.8589","44 CAL120 Combination":"13675.6068","22 HCC1806 GSK 1 uM":"15438.3761","25 HCC1806 GSK 1 uM":"12850.1781","21 HCC1806 DMM 5 mM":"7765.0853","24 HCC1806 DMM 5 mM":"8738.7666","23 HCC1806 Combination":"9740.9194","26 HCC1806 Combination":"10387.9054","34 HS578T GSK 1 uM":"7990.5251","37 HS578T GSK 1 uM":"15443.3118","33 HS578T DMM 5 mM":"14485.8893","36 HS578T DMM 5 mM":"12102.1403","35 HS578T Combination":"9995.9260","38 HS578T Combination":"8240.2691","16 MCF7 GSK 1 uM":"11531.7163","19 MCF7 GSK 1 uM":"7544.0329","15 MCF7 DMM 5 mM":"12422.5755","18 MCF7 DMM 5 mM":"12921.6517","17 MCF7 Combination":"9083.3309","20 MCF7 Combination":"8200.7292","28 MDA-MB-231 GSK 1 uM":"10016.9692","31 MDA-MB-231 GSK 1 uM":"8584.2745","27 MDA-MB-231 DMM 5 mM":"11529.2151","30 MDA-MB-231 DMM 5 mM":"10937.0741","29 MDA-MB-231 Combination":"8689.6365","32 MDA-MB-231 Combination":"8183.9778","04 MDA-MB-468 GSK 1 uM":"23449.8422","07 MDA-MB-468 GSK 1 uM":"16375.7536","03 MDA-MB-468 DMM 5 mM":"22042.5476","06 MDA-MB-468 DMM 5 mM":"21869.7484","05 MDA-MB-468 Combination":"15504.9196","08 MDA-MB-468 Combination":"18812.7386","01 Blank":"1198.2942","46 Blank":"1352.1254","02 DMEM/F12 no adds":"868.0911","45 DMEM/F12 no adds":"1280.6737","10 SUM159PT GSK 1 uM":"10009.8222","13 SUM159PT GSK 1 uM":"12275.9501","09 SUM159PT DMM 5 mM":"29785.7433","12 SUM159PT DMM 5 mM":"21953.7070","11 SUM159PT Combination":"12533.0483","14 SUM159PT Combination":"7956.9420"},{"Metabolite":"O-Undecyloyl-L-carnitine 85","40 CAL120 GSK 1 uM":"4565.8158","43 CAL120 GSK 1 uM":"6866.2955","39 CAL120 DMM 5 mM":"5349.5039","42 CAL120 DMM 5 mM":"12789.9696","41 CAL120 Combination":"7680.4350","44 CAL120 Combination":"7208.9683","22 HCC1806 GSK 1 uM":"7037.8678","25 HCC1806 GSK 1 uM":"7403.9100","21 HCC1806 DMM 5 mM":"9237.8999","24 HCC1806 DMM 5 mM":"6989.2166","23 HCC1806 Combination":"22892.7581","26 HCC1806 Combination":"11068.4712","34 HS578T GSK 1 uM":"11188.2015","37 HS578T GSK 1 uM":"6328.1682","33 HS578T DMM 5 mM":"7662.1668","36 HS578T DMM 5 mM":"4712.3538","35 HS578T Combination":"11174.5272","38 HS578T Combination":"7143.1464","16 MCF7 GSK 1 uM":"5575.6665","19 MCF7 GSK 1 uM":"6554.5433","15 MCF7 DMM 5 mM":"5103.9042","18 MCF7 DMM 5 mM":"5275.9606","17 MCF7 Combination":"3569.1417","20 MCF7 Combination":"5757.3334","28 MDA-MB-231 GSK 1 uM":"7908.5953","31 MDA-MB-231 GSK 1 uM":"4805.0344","27 MDA-MB-231 DMM 5 mM":"5614.9337","30 MDA-MB-231 DMM 5 mM":"7955.9591","29 MDA-MB-231 Combination":"7705.7028","32 MDA-MB-231 Combination":"3456.6953","04 MDA-MB-468 GSK 1 uM":"12836.2586","07 MDA-MB-468 GSK 1 uM":"9844.2195","03 MDA-MB-468 DMM 5 mM":"18038.4020","06 MDA-MB-468 DMM 5 mM":"13917.3049","05 MDA-MB-468 Combination":"15437.7825","08 MDA-MB-468 Combination":"14110.1784","01 Blank":"1669.9729","46 Blank":"1101.8232","02 DMEM/F12 no adds":"1489.2990","45 DMEM/F12 no adds":"3492.5999","10 SUM159PT GSK 1 uM":"9633.8314","13 SUM159PT GSK 1 uM":"10286.1940","09 SUM159PT DMM 5 mM":"5908.8061","12 SUM159PT DMM 5 mM":"10084.0729","11 SUM159PT Combination":"9016.0044","14 SUM159PT Combination":"12876.3215"},{"Metabolite":"O-Valeryl-L-carnitine 85","40 CAL120 GSK 1 uM":"18026883.1000","43 CAL120 GSK 1 uM":"18981000.8400","39 CAL120 DMM 5 mM":"11633715.3300","42 CAL120 DMM 5 mM":"10704475.9500","41 CAL120 Combination":"9309680.7350","44 CAL120 Combination":"10039598.5900","22 HCC1806 GSK 1 uM":"1552399.8250","25 HCC1806 GSK 1 uM":"1335446.5940","21 HCC1806 DMM 5 mM":"1372915.8120","24 HCC1806 DMM 5 mM":"1378859.5580","23 HCC1806 Combination":"1072997.3420","26 HCC1806 Combination":"889849.6347","34 HS578T GSK 1 uM":"3005948.4720","37 HS578T GSK 1 uM":"2627250.8220","33 HS578T DMM 5 mM":"1778238.6820","36 HS578T DMM 5 mM":"1755361.5650","35 HS578T Combination":"2026470.9840","38 HS578T Combination":"1547575.6080","16 MCF7 GSK 1 uM":"35690020.2300","19 MCF7 GSK 1 uM":"46697977.6000","15 MCF7 DMM 5 mM":"11175190.7200","18 MCF7 DMM 5 mM":"11024490.8700","17 MCF7 Combination":"8931658.2610","20 MCF7 Combination":"4930872.5300","28 MDA-MB-231 GSK 1 uM":"2421950.2440","31 MDA-MB-231 GSK 1 uM":"2663308.0010","27 MDA-MB-231 DMM 5 mM":"1871629.3930","30 MDA-MB-231 DMM 5 mM":"2016437.0890","29 MDA-MB-231 Combination":"2217235.4550","32 MDA-MB-231 Combination":"1866446.5430","04 MDA-MB-468 GSK 1 uM":"2691137.2880","07 MDA-MB-468 GSK 1 uM":"2715184.0430","03 MDA-MB-468 DMM 5 mM":"3869082.2690","06 MDA-MB-468 DMM 5 mM":"3001546.2320","05 MDA-MB-468 Combination":"3377987.7360","08 MDA-MB-468 Combination":"3418428.9440","01 Blank":"1406427.1330","46 Blank":"1530669.8900","02 DMEM/F12 no adds":"50176.2384","45 DMEM/F12 no adds":"47851.9057","10 SUM159PT GSK 1 uM":"12367369.9200","13 SUM159PT GSK 1 uM":"12568116.0000","09 SUM159PT DMM 5 mM":"4929017.2440","12 SUM159PT DMM 5 mM":"5488608.3550","11 SUM159PT Combination":"6812898.6780","14 SUM159PT Combination":"8415640.1530"},{"Metabolite":"pABA 120","40 CAL120 GSK 1 uM":"22425.4189","43 CAL120 GSK 1 uM":"30172.7941","39 CAL120 DMM 5 mM":"17591.2651","42 CAL120 DMM 5 mM":"21276.6101","41 CAL120 Combination":"18317.7831","44 CAL120 Combination":"13669.1876","22 HCC1806 GSK 1 uM":"75065.6298","25 HCC1806 GSK 1 uM":"86005.6673","21 HCC1806 DMM 5 mM":"33162.1473","24 HCC1806 DMM 5 mM":"25204.5991","23 HCC1806 Combination":"66639.8801","26 HCC1806 Combination":"86190.6771","34 HS578T GSK 1 uM":"9718.4747","37 HS578T GSK 1 uM":"17329.8541","33 HS578T DMM 5 mM":"9158.0056","36 HS578T DMM 5 mM":"10202.8599","35 HS578T Combination":"9624.3816","38 HS578T Combination":"17081.3277","16 MCF7 GSK 1 uM":"10036.3339","19 MCF7 GSK 1 uM":"10047.9306","15 MCF7 DMM 5 mM":"8662.1008","18 MCF7 DMM 5 mM":"12635.3086","17 MCF7 Combination":"4604.8906","20 MCF7 Combination":"7024.6961","28 MDA-MB-231 GSK 1 uM":"7426.1532","31 MDA-MB-231 GSK 1 uM":"7351.1774","27 MDA-MB-231 DMM 5 mM":"20107.7438","30 MDA-MB-231 DMM 5 mM":"13974.4609","29 MDA-MB-231 Combination":"10726.5432","32 MDA-MB-231 Combination":"6191.6778","04 MDA-MB-468 GSK 1 uM":"5306.1725","07 MDA-MB-468 GSK 1 uM":"13084.5698","03 MDA-MB-468 DMM 5 mM":"13482.2240","06 MDA-MB-468 DMM 5 mM":"4053.4678","05 MDA-MB-468 Combination":"9028.2101","08 MDA-MB-468 Combination":"11221.2738","01 Blank":"4776.5334","46 Blank":"4241.7995","02 DMEM/F12 no adds":"70465.8013","45 DMEM/F12 no adds":"63621.8034","10 SUM159PT GSK 1 uM":"9110.3361","13 SUM159PT GSK 1 uM":"2926.6774","09 SUM159PT DMM 5 mM":"7290.4817","12 SUM159PT DMM 5 mM":"4355.6942","11 SUM159PT Combination":"4548.2028","14 SUM159PT Combination":"4520.3315"},{"Metabolite":"Pantothenic 202","40 CAL120 GSK 1 uM":"2738604.5900","43 CAL120 GSK 1 uM":"3267680.8330","39 CAL120 DMM 5 mM":"3279324.4650","42 CAL120 DMM 5 mM":"2821927.8620","41 CAL120 Combination":"2773365.6610","44 CAL120 Combination":"2873508.2050","22 HCC1806 GSK 1 uM":"3107820.9660","25 HCC1806 GSK 1 uM":"3042691.4450","21 HCC1806 DMM 5 mM":"3706752.9800","24 HCC1806 DMM 5 mM":"3480599.4250","23 HCC1806 Combination":"2917834.9670","26 HCC1806 Combination":"3071373.3810","34 HS578T GSK 1 uM":"1572396.4180","37 HS578T GSK 1 uM":"1615211.8280","33 HS578T DMM 5 mM":"1383588.3170","36 HS578T DMM 5 mM":"1400691.1320","35 HS578T Combination":"1558763.6770","38 HS578T Combination":"1299347.2890","16 MCF7 GSK 1 uM":"3981788.6720","19 MCF7 GSK 1 uM":"5298832.1320","15 MCF7 DMM 5 mM":"3743541.4340","18 MCF7 DMM 5 mM":"3451995.3530","17 MCF7 Combination":"3770608.9450","20 MCF7 Combination":"2416063.7850","28 MDA-MB-231 GSK 1 uM":"2532842.9350","31 MDA-MB-231 GSK 1 uM":"2849534.3510","27 MDA-MB-231 DMM 5 mM":"2276357.5860","30 MDA-MB-231 DMM 5 mM":"2485624.1890","29 MDA-MB-231 Combination":"2398538.2360","32 MDA-MB-231 Combination":"2287313.8430","04 MDA-MB-468 GSK 1 uM":"8165908.0500","07 MDA-MB-468 GSK 1 uM":"8149336.2810","03 MDA-MB-468 DMM 5 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Combination":"10202438.4500","34 HS578T GSK 1 uM":"4176787.8400","37 HS578T GSK 1 uM":"10893488.8300","33 HS578T DMM 5 mM":"8327854.6850","36 HS578T DMM 5 mM":"5142710.9720","35 HS578T Combination":"7917107.7070","38 HS578T Combination":"4001584.5500","16 MCF7 GSK 1 uM":"11231368.7900","19 MCF7 GSK 1 uM":"7923149.6170","15 MCF7 DMM 5 mM":"11228937.2300","18 MCF7 DMM 5 mM":"16030573.9600","17 MCF7 Combination":"7383964.2620","20 MCF7 Combination":"4491886.5870","28 MDA-MB-231 GSK 1 uM":"12818016.1600","31 MDA-MB-231 GSK 1 uM":"10702711.2900","27 MDA-MB-231 DMM 5 mM":"11894586.0500","30 MDA-MB-231 DMM 5 mM":"14981810.2400","29 MDA-MB-231 Combination":"9597057.0990","32 MDA-MB-231 Combination":"6658959.6560","04 MDA-MB-468 GSK 1 uM":"30302737.5600","07 MDA-MB-468 GSK 1 uM":"33197467.5900","03 MDA-MB-468 DMM 5 mM":"36458015.9400","06 MDA-MB-468 DMM 5 mM":"33080345.8500","05 MDA-MB-468 Combination":"23975575.6800","08 MDA-MB-468 Combination":"31953651.2500","01 Blank":"1325.1352","46 Blank":"4777.3599","02 DMEM/F12 no adds":"2902.3334","45 DMEM/F12 no adds":"4355.5263","10 SUM159PT GSK 1 uM":"6067308.5540","13 SUM159PT GSK 1 uM":"5409322.1950","09 SUM159PT DMM 5 mM":"7171820.6950","12 SUM159PT DMM 5 mM":"4212366.1380","11 SUM159PT Combination":"4292843.6060","14 SUM159PT Combination":"5764646.1800"},{"Metabolite":"Proline 70","40 CAL120 GSK 1 uM":"30204404.7100","43 CAL120 GSK 1 uM":"32030286.2400","39 CAL120 DMM 5 mM":"27167835.2100","42 CAL120 DMM 5 mM":"27052733.2400","41 CAL120 Combination":"25977229.6000","44 CAL120 Combination":"25359198.5600","22 HCC1806 GSK 1 uM":"49554335.7900","25 HCC1806 GSK 1 uM":"50352577.4400","21 HCC1806 DMM 5 mM":"44549872.8800","24 HCC1806 DMM 5 mM":"46319375.4000","23 HCC1806 Combination":"44419996.0500","26 HCC1806 Combination":"44364543.7900","34 HS578T GSK 1 uM":"11162509.9100","37 HS578T GSK 1 uM":"10297574.9100","33 HS578T DMM 5 mM":"6582491.0170","36 HS578T DMM 5 mM":"7718179.1080","35 HS578T Combination":"8356825.5400","38 HS578T Combination":"6929842.0590","16 MCF7 GSK 1 uM":"18713540.8000","19 MCF7 GSK 1 uM":"21808196.0500","15 MCF7 DMM 5 mM":"21589723.2500","18 MCF7 DMM 5 mM":"21167452.5100","17 MCF7 Combination":"20409733.4100","20 MCF7 Combination":"12577216.9000","28 MDA-MB-231 GSK 1 uM":"18416186.8300","31 MDA-MB-231 GSK 1 uM":"20748941.8200","27 MDA-MB-231 DMM 5 mM":"15590020.9600","30 MDA-MB-231 DMM 5 mM":"15516708.6300","29 MDA-MB-231 Combination":"12872405.5200","32 MDA-MB-231 Combination":"14343876.0600","04 MDA-MB-468 GSK 1 uM":"44854458.6000","07 MDA-MB-468 GSK 1 uM":"46451124.6800","03 MDA-MB-468 DMM 5 mM":"36822114.1700","06 MDA-MB-468 DMM 5 mM":"36942997.7900","05 MDA-MB-468 Combination":"35438981.1100","08 MDA-MB-468 Combination":"37926679.0500","01 Blank":"1069.7044","46 Blank":"2744.3556","02 DMEM/F12 no adds":"15850586.4000","45 DMEM/F12 no adds":"14639935.3700","10 SUM159PT GSK 1 uM":"38087824.3300","13 SUM159PT GSK 1 uM":"47309282.7100","09 SUM159PT DMM 5 mM":"30713617.6000","12 SUM159PT DMM 5 mM":"30067121.2200","11 SUM159PT Combination":"27982999.8100","14 SUM159PT Combination":"29546809.4300"},{"Metabolite":"Puro Heavy 121","40 CAL120 GSK 1 uM":"3630.4358","43 CAL120 GSK 1 uM":"3767.4325","39 CAL120 DMM 5 mM":"2547.4236","42 CAL120 DMM 5 mM":"3935.7518","41 CAL120 Combination":"3553.7154","44 CAL120 Combination":"2781.1957","22 HCC1806 GSK 1 uM":"8381.8535","25 HCC1806 GSK 1 uM":"6344.3594","21 HCC1806 DMM 5 mM":"6125.7747","24 HCC1806 DMM 5 mM":"3267.1356","23 HCC1806 Combination":"4436.2551","26 HCC1806 Combination":"5571.7393","34 HS578T GSK 1 uM":"4446.1326","37 HS578T GSK 1 uM":"7275.1971","33 HS578T DMM 5 mM":"3645.2714","36 HS578T DMM 5 mM":"5748.3125","35 HS578T Combination":"4769.3268","38 HS578T Combination":"1204.2902","16 MCF7 GSK 1 uM":"1586.5099","19 MCF7 GSK 1 uM":"1797.5714","15 MCF7 DMM 5 mM":"1210.1777","18 MCF7 DMM 5 mM":"989.4780","17 MCF7 Combination":"2599.7770","20 MCF7 Combination":"1726.5557","28 MDA-MB-231 GSK 1 uM":"3693.3930","31 MDA-MB-231 GSK 1 uM":"2749.1806","27 MDA-MB-231 DMM 5 mM":"2959.2057","30 MDA-MB-231 DMM 5 mM":"3094.3917","29 MDA-MB-231 Combination":"1141.7265","32 MDA-MB-231 Combination":"2790.2604","04 MDA-MB-468 GSK 1 uM":"1064.9803","07 MDA-MB-468 GSK 1 uM":"1037.2323","03 MDA-MB-468 DMM 5 mM":"1006.5953","06 MDA-MB-468 DMM 5 mM":"3703.9811","05 MDA-MB-468 Combination":"1338.2047","08 MDA-MB-468 Combination":"2225.4245","01 Blank":"503.4506","46 Blank":"1151.9878","02 DMEM/F12 no adds":"858.6534","45 DMEM/F12 no adds":"2040.1816","10 SUM159PT GSK 1 uM":"1199.1057","13 SUM159PT GSK 1 uM":"2550.5779","09 SUM159PT DMM 5 mM":"3885.1800","12 SUM159PT DMM 5 mM":"1782.3671","11 SUM159PT Combination":"1759.5608","14 SUM159PT Combination":"2950.9025"},{"Metabolite":"Pyridoxine 134","40 CAL120 GSK 1 uM":"2401841.2000","43 CAL120 GSK 1 uM":"2339267.9000","39 CAL120 DMM 5 mM":"2700727.1930","42 CAL120 DMM 5 mM":"1807411.1620","41 CAL120 Combination":"2177753.5000","44 CAL120 Combination":"1409781.9010","22 HCC1806 GSK 1 uM":"3460018.6870","25 HCC1806 GSK 1 uM":"4316721.7450","21 HCC1806 DMM 5 mM":"4128118.9750","24 HCC1806 DMM 5 mM":"2745758.1550","23 HCC1806 Combination":"2321859.7660","26 HCC1806 Combination":"2671648.0200","34 HS578T GSK 1 uM":"1126625.8000","37 HS578T GSK 1 uM":"1852051.7000","33 HS578T DMM 5 mM":"1671830.9000","36 HS578T DMM 5 mM":"1109606.5000","35 HS578T Combination":"1560626.0000","38 HS578T Combination":"1139841.7000","16 MCF7 GSK 1 uM":"1917953.5000","19 MCF7 GSK 1 uM":"1736404.2000","15 MCF7 DMM 5 mM":"2382546.6000","18 MCF7 DMM 5 mM":"2703121.9540","17 MCF7 Combination":"1575102.2000","20 MCF7 Combination":"931873.3000","28 MDA-MB-231 GSK 1 uM":"2820218.0140","31 MDA-MB-231 GSK 1 uM":"2459666.0140","27 MDA-MB-231 DMM 5 mM":"2290723.3630","30 MDA-MB-231 DMM 5 mM":"3249135.3260","29 MDA-MB-231 Combination":"2029016.9110","32 MDA-MB-231 Combination":"1829296.4850","04 MDA-MB-468 GSK 1 uM":"5687203.7870","07 MDA-MB-468 GSK 1 uM":"6830237.1940","03 MDA-MB-468 DMM 5 mM":"6193869.7530","06 MDA-MB-468 DMM 5 mM":"5547600.4160","05 MDA-MB-468 Combination":"5156186.6780","08 MDA-MB-468 Combination":"5820357.7280","01 Blank":"","46 Blank":"887.2000","02 DMEM/F12 no adds":"37520795.0700","45 DMEM/F12 no adds":"38728836.0900","10 SUM159PT GSK 1 uM":"1985535.0000","13 SUM159PT GSK 1 uM":"2621235.2400","09 SUM159PT DMM 5 mM":"1950424.2100","12 SUM159PT DMM 5 mM":"2136566.2000","11 SUM159PT Combination":"1613618.7000","14 SUM159PT Combination":"2341049.0000"},{"Metabolite":"Pyridoxine 152","40 CAL120 GSK 1 uM":"2473631.4750","43 CAL120 GSK 1 uM":"2286380.2490","39 CAL120 DMM 5 mM":"3679352.2600","42 CAL120 DMM 5 mM":"2043164.7070","41 CAL120 Combination":"2314983.2050","44 CAL120 Combination":"1888293.1000","22 HCC1806 GSK 1 uM":"4357368.3960","25 HCC1806 GSK 1 uM":"4029518.0770","21 HCC1806 DMM 5 mM":"6270092.9070","24 HCC1806 DMM 5 mM":"3329787.3340","23 HCC1806 Combination":"3596598.7830","26 HCC1806 Combination":"3070228.4370","34 HS578T GSK 1 uM":"1823578.0000","37 HS578T GSK 1 uM":"2663315.8060","33 HS578T DMM 5 mM":"1728310.6110","36 HS578T DMM 5 mM":"1538610.1000","35 HS578T Combination":"1796128.6450","38 HS578T Combination":"1176484.0000","16 MCF7 GSK 1 uM":"2244020.8200","19 MCF7 GSK 1 uM":"2001781.6370","15 MCF7 DMM 5 mM":"2856436.1490","18 MCF7 DMM 5 mM":"4067157.0890","17 MCF7 Combination":"1975783.1480","20 MCF7 Combination":"1256821.8080","28 MDA-MB-231 GSK 1 uM":"3768551.0200","31 MDA-MB-231 GSK 1 uM":"3060269.2930","27 MDA-MB-231 DMM 5 mM":"2744623.3610","30 MDA-MB-231 DMM 5 mM":"3251316.4950","29 MDA-MB-231 Combination":"2464241.2650","32 MDA-MB-231 Combination":"2284669.2500","04 MDA-MB-468 GSK 1 uM":"6776173.0860","07 MDA-MB-468 GSK 1 uM":"7353720.7050","03 MDA-MB-468 DMM 5 mM":"7773927.8670","06 MDA-MB-468 DMM 5 mM":"6759668.6190","05 MDA-MB-468 Combination":"5246928.3330","08 MDA-MB-468 Combination":"6819315.6070","01 Blank":"10298.3000","46 Blank":"15436.5000","02 DMEM/F12 no adds":"47460748.3900","45 DMEM/F12 no adds":"48458696.2700","10 SUM159PT GSK 1 uM":"2048009.8130","13 SUM159PT GSK 1 uM":"2908855.5470","09 SUM159PT DMM 5 mM":"2350291.8550","12 SUM159PT DMM 5 mM":"2026833.0130","11 SUM159PT Combination":"2177293.2000","14 SUM159PT Combination":"2315401.5510"},{"Metabolite":"Pyroglutamic 84","40 CAL120 GSK 1 uM":"81629682.7100","43 CAL120 GSK 1 uM":"73496419.3100","39 CAL120 DMM 5 mM":"103538883.8000","42 CAL120 DMM 5 mM":"82510848.9800","41 CAL120 Combination":"92555085.4300","44 CAL120 Combination":"76768369.1700","22 HCC1806 GSK 1 uM":"158363809.4000","25 HCC1806 GSK 1 uM":"164669315.1000","21 HCC1806 DMM 5 mM":"208614410.5000","24 HCC1806 DMM 5 mM":"153690984.9000","23 HCC1806 Combination":"150465423.5000","26 HCC1806 Combination":"158578960.4000","34 HS578T GSK 1 uM":"53841130.0500","37 HS578T GSK 1 uM":"86976274.4500","33 HS578T DMM 5 mM":"71951307.0800","36 HS578T DMM 5 mM":"55746310.8900","35 HS578T Combination":"81832928.8900","38 HS578T Combination":"51422278.4200","16 MCF7 GSK 1 uM":"137564152.9000","19 MCF7 GSK 1 uM":"137102886.1000","15 MCF7 DMM 5 mM":"151674795.3000","18 MCF7 DMM 5 mM":"190942841.2000","17 MCF7 Combination":"137473374.6000","20 MCF7 Combination":"83677565.7800","28 MDA-MB-231 GSK 1 uM":"134461533.8000","31 MDA-MB-231 GSK 1 uM":"122887217.9000","27 MDA-MB-231 DMM 5 mM":"156177891.2000","30 MDA-MB-231 DMM 5 mM":"161844711.2000","29 MDA-MB-231 Combination":"123060315.9000","32 MDA-MB-231 Combination":"121815093.6000","04 MDA-MB-468 GSK 1 uM":"240891953.5000","07 MDA-MB-468 GSK 1 uM":"256724199.1000","03 MDA-MB-468 DMM 5 mM":"269687073.1000","06 MDA-MB-468 DMM 5 mM":"272043087.2000","05 MDA-MB-468 Combination":"232199728.9000","08 MDA-MB-468 Combination":"268851043.3000","01 Blank":"","46 Blank":"25239.6662","02 DMEM/F12 no adds":"50887170.3400","45 DMEM/F12 no adds":"55007051.5400","10 SUM159PT GSK 1 uM":"107429600.5000","13 SUM159PT GSK 1 uM":"126185682.4000","09 SUM159PT DMM 5 mM":"107181197.7000","12 SUM159PT DMM 5 mM":"111460046.5000","11 SUM159PT Combination":"98170361.3600","14 SUM159PT Combination":"110774772.0000"},{"Metabolite":"Rotenone 213","40 CAL120 GSK 1 uM":"2596.6320","43 CAL120 GSK 1 uM":"917.3060","39 CAL120 DMM 5 mM":"726.1335","42 CAL120 DMM 5 mM":"3770.7225","41 CAL120 Combination":"1452.2148","44 CAL120 Combination":"1688.0738","22 HCC1806 GSK 1 uM":"2443.9445","25 HCC1806 GSK 1 uM":"1914.0431","21 HCC1806 DMM 5 mM":"720.4126","24 HCC1806 DMM 5 mM":"2619.9423","23 HCC1806 Combination":"601.0000","26 HCC1806 Combination":"1234.4011","34 HS578T GSK 1 uM":"2464.8487","37 HS578T GSK 1 uM":"1402.6489","33 HS578T DMM 5 mM":"1345.7982","36 HS578T DMM 5 mM":"1319.0575","35 HS578T Combination":"1393.2036","38 HS578T Combination":"970.0906","16 MCF7 GSK 1 uM":"1429.6501","19 MCF7 GSK 1 uM":"2683.8349","15 MCF7 DMM 5 mM":"934.2976","18 MCF7 DMM 5 mM":"2149.4886","17 MCF7 Combination":"2048.7662","20 MCF7 Combination":"2620.4433","28 MDA-MB-231 GSK 1 uM":"801.6625","31 MDA-MB-231 GSK 1 uM":"1781.3031","27 MDA-MB-231 DMM 5 mM":"2108.0432","30 MDA-MB-231 DMM 5 mM":"1950.8749","29 MDA-MB-231 Combination":"4520.3841","32 MDA-MB-231 Combination":"2383.3184","04 MDA-MB-468 GSK 1 uM":"1849.3230","07 MDA-MB-468 GSK 1 uM":"2058.1518","03 MDA-MB-468 DMM 5 mM":"3141.0806","06 MDA-MB-468 DMM 5 mM":"1928.4873","05 MDA-MB-468 Combination":"1950.7769","08 MDA-MB-468 Combination":"2052.2405","01 Blank":"1399.7347","46 Blank":"2297.0807","02 DMEM/F12 no adds":"860.8656","45 DMEM/F12 no adds":"2238.0224","10 SUM159PT GSK 1 uM":"820.4214","13 SUM159PT GSK 1 uM":"2044.2849","09 SUM159PT DMM 5 mM":"1696.3126","12 SUM159PT DMM 5 mM":"1732.2332","11 SUM159PT Combination":"2092.7250","14 SUM159PT Combination":"2155.8974"},{"Metabolite":"Sarcosine 30","40 CAL120 GSK 1 uM":"7252.5185","43 CAL120 GSK 1 uM":"3601.2396","39 CAL120 DMM 5 mM":"13900.0754","42 CAL120 DMM 5 mM":"3273.6717","41 CAL120 Combination":"4732.7986","44 CAL120 Combination":"981.0777","22 HCC1806 GSK 1 uM":"15233.0715","25 HCC1806 GSK 1 uM":"4388.5166","21 HCC1806 DMM 5 mM":"19315.9145","24 HCC1806 DMM 5 mM":"6476.9378","23 HCC1806 Combination":"9264.8553","26 HCC1806 Combination":"8258.4611","34 HS578T GSK 1 uM":"14612.7344","37 HS578T GSK 1 uM":"15172.2893","33 HS578T DMM 5 mM":"17222.2163","36 HS578T DMM 5 mM":"17082.5147","35 HS578T Combination":"19223.2961","38 HS578T Combination":"3621.9722","16 MCF7 GSK 1 uM":"6879.3284","19 MCF7 GSK 1 uM":"5999.9651","15 MCF7 DMM 5 mM":"17502.3339","18 MCF7 DMM 5 mM":"19352.4233","17 MCF7 Combination":"6291.9390","20 MCF7 Combination":"16828.9126","28 MDA-MB-231 GSK 1 uM":"11628.2296","31 MDA-MB-231 GSK 1 uM":"19127.6863","27 MDA-MB-231 DMM 5 mM":"16795.1237","30 MDA-MB-231 DMM 5 mM":"18020.5775","29 MDA-MB-231 Combination":"15933.0872","32 MDA-MB-231 Combination":"19229.1929","04 MDA-MB-468 GSK 1 uM":"70598.3543","07 MDA-MB-468 GSK 1 uM":"83133.7088","03 MDA-MB-468 DMM 5 mM":"67769.5432","06 MDA-MB-468 DMM 5 mM":"50651.1636","05 MDA-MB-468 Combination":"69383.3905","08 MDA-MB-468 Combination":"61925.2734","01 Blank":"3603.9260","46 Blank":"7051.6124","02 DMEM/F12 no adds":"8283.3208","45 DMEM/F12 no adds":"16382.2145","10 SUM159PT GSK 1 uM":"14465.2929","13 SUM159PT GSK 1 uM":"13054.3216","09 SUM159PT DMM 5 mM":"1128.8079","12 SUM159PT DMM 5 mM":"13463.2367","11 SUM159PT Combination":"18673.4986","14 SUM159PT Combination":"10783.9050"},{"Metabolite":"Sarcosine 44","40 CAL120 GSK 1 uM":"87543.3738","43 CAL120 GSK 1 uM":"91811.8640","39 CAL120 DMM 5 mM":"86042.9226","42 CAL120 DMM 5 mM":"89480.1136","41 CAL120 Combination":"170184.1869","44 CAL120 Combination":"155433.8501","22 HCC1806 GSK 1 uM":"295325.1219","25 HCC1806 GSK 1 uM":"264998.6396","21 HCC1806 DMM 5 mM":"254301.9521","24 HCC1806 DMM 5 mM":"281101.7549","23 HCC1806 Combination":"269732.8227","26 HCC1806 Combination":"279366.9764","34 HS578T GSK 1 uM":"191169.3416","37 HS578T GSK 1 uM":"196348.4532","33 HS578T DMM 5 mM":"175805.3936","36 HS578T DMM 5 mM":"165687.5258","35 HS578T Combination":"196988.1280","38 HS578T Combination":"83386.1342","16 MCF7 GSK 1 uM":"256612.6063","19 MCF7 GSK 1 uM":"322619.4356","15 MCF7 DMM 5 mM":"241629.0842","18 MCF7 DMM 5 mM":"331136.8741","17 MCF7 Combination":"288193.4901","20 MCF7 Combination":"204360.1160","28 MDA-MB-231 GSK 1 uM":"243637.7687","31 MDA-MB-231 GSK 1 uM":"266090.2999","27 MDA-MB-231 DMM 5 mM":"222731.3634","30 MDA-MB-231 DMM 5 mM":"227216.4994","29 MDA-MB-231 Combination":"234715.7948","32 MDA-MB-231 Combination":"208135.3796","04 MDA-MB-468 GSK 1 uM":"2828058.7920","07 MDA-MB-468 GSK 1 uM":"3067640.9540","03 MDA-MB-468 DMM 5 mM":"2485354.2050","06 MDA-MB-468 DMM 5 mM":"2220752.8460","05 MDA-MB-468 Combination":"2536011.0590","08 MDA-MB-468 Combination":"2452662.5860","01 Blank":"6879.9562","46 Blank":"43833.5726","02 DMEM/F12 no adds":"18284.6764","45 DMEM/F12 no adds":"77218.8870","10 SUM159PT GSK 1 uM":"221493.3004","13 SUM159PT GSK 1 uM":"302257.6910","09 SUM159PT DMM 5 mM":"152359.4010","12 SUM159PT DMM 5 mM":"155134.6320","11 SUM159PT Combination":"153554.8345","14 SUM159PT Combination":"156474.8092"},{"Metabolite":"Serine 60","40 CAL120 GSK 1 uM":"5178941.2050","43 CAL120 GSK 1 uM":"5399998.8130","39 CAL120 DMM 5 mM":"4895772.2580","42 CAL120 DMM 5 mM":"4259230.2440","41 CAL120 Combination":"3915024.2340","44 CAL120 Combination":"3863735.4420","22 HCC1806 GSK 1 uM":"8560275.9870","25 HCC1806 GSK 1 uM":"8340429.5970","21 HCC1806 DMM 5 mM":"13319300.5100","24 HCC1806 DMM 5 mM":"12922632.2700","23 HCC1806 Combination":"12550374.4100","26 HCC1806 Combination":"12522136.2400","34 HS578T GSK 1 uM":"10549774.2000","37 HS578T GSK 1 uM":"11198621.7800","33 HS578T DMM 5 mM":"8183703.9740","36 HS578T DMM 5 mM":"8096686.3020","35 HS578T Combination":"8635264.5710","38 HS578T Combination":"8074407.2080","16 MCF7 GSK 1 uM":"3734112.6220","19 MCF7 GSK 1 uM":"4622702.9290","15 MCF7 DMM 5 mM":"6093152.7830","18 MCF7 DMM 5 mM":"7010734.1100","17 MCF7 Combination":"5545928.8750","20 MCF7 Combination":"3883820.4550","28 MDA-MB-231 GSK 1 uM":"1527348.4780","31 MDA-MB-231 GSK 1 uM":"1514905.7820","27 MDA-MB-231 DMM 5 mM":"1760347.7480","30 MDA-MB-231 DMM 5 mM":"1876096.0240","29 MDA-MB-231 Combination":"1774299.6830","32 MDA-MB-231 Combination":"1694469.0900","04 MDA-MB-468 GSK 1 uM":"8428764.6280","07 MDA-MB-468 GSK 1 uM":"9263332.8340","03 MDA-MB-468 DMM 5 mM":"11732963.9300","06 MDA-MB-468 DMM 5 mM":"11667491.6300","05 MDA-MB-468 Combination":"10248722.1200","08 MDA-MB-468 Combination":"11129648.4300","01 Blank":"5024.3102","46 Blank":"12421.0352","02 DMEM/F12 no adds":"16439825.4100","45 DMEM/F12 no adds":"25407762.5400","10 SUM159PT GSK 1 uM":"2324913.8580","13 SUM159PT GSK 1 uM":"2646352.9460","09 SUM159PT DMM 5 mM":"2922967.4460","12 SUM159PT DMM 5 mM":"2950812.1230","11 SUM159PT Combination":"3039298.7560","14 SUM159PT Combination":"3301135.6980"},{"Metabolite":"Thiamine 122","40 CAL120 GSK 1 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uM":"3521154.2540","25 HCC1806 GSK 1 uM":"3328838.7920","21 HCC1806 DMM 5 mM":"5074909.8200","24 HCC1806 DMM 5 mM":"4876578.8020","23 HCC1806 Combination":"4893301.7920","26 HCC1806 Combination":"4797813.6860","34 HS578T GSK 1 uM":"3339397.1790","37 HS578T GSK 1 uM":"3585052.8560","33 HS578T DMM 5 mM":"2826093.8280","36 HS578T DMM 5 mM":"2876552.3140","35 HS578T Combination":"2996356.4490","38 HS578T Combination":"2499670.0980","16 MCF7 GSK 1 uM":"2319235.6530","19 MCF7 GSK 1 uM":"2668334.7020","15 MCF7 DMM 5 mM":"2883039.5420","18 MCF7 DMM 5 mM":"3392411.1580","17 MCF7 Combination":"2507602.7030","20 MCF7 Combination":"2026309.0300","28 MDA-MB-231 GSK 1 uM":"2165525.7320","31 MDA-MB-231 GSK 1 uM":"2110519.2460","27 MDA-MB-231 DMM 5 mM":"1961013.2820","30 MDA-MB-231 DMM 5 mM":"2267828.3690","29 MDA-MB-231 Combination":"2142310.3400","32 MDA-MB-231 Combination":"1947050.9780","04 MDA-MB-468 GSK 1 uM":"4821717.8000","07 MDA-MB-468 GSK 1 uM":"5556454.3060","03 MDA-MB-468 DMM 5 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uM":"526890.8436","13 SUM159PT GSK 1 uM":"760445.9336","09 SUM159PT DMM 5 mM":"2269301.4150","12 SUM159PT DMM 5 mM":"2240594.4210","11 SUM159PT Combination":"2333872.1710","14 SUM159PT Combination":"2778271.7620"},{"Metabolite":"TVB-2640 386","40 CAL120 GSK 1 uM":"","43 CAL120 GSK 1 uM":"","39 CAL120 DMM 5 mM":"","42 CAL120 DMM 5 mM":"","41 CAL120 Combination":"","44 CAL120 Combination":"","22 HCC1806 GSK 1 uM":"","25 HCC1806 GSK 1 uM":"","21 HCC1806 DMM 5 mM":"","24 HCC1806 DMM 5 mM":"","23 HCC1806 Combination":"","26 HCC1806 Combination":"","34 HS578T GSK 1 uM":"","37 HS578T GSK 1 uM":"","33 HS578T DMM 5 mM":"","36 HS578T DMM 5 mM":"","35 HS578T Combination":"","38 HS578T Combination":"","16 MCF7 GSK 1 uM":"","19 MCF7 GSK 1 uM":"","15 MCF7 DMM 5 mM":"","18 MCF7 DMM 5 mM":"","17 MCF7 Combination":"","20 MCF7 Combination":"358.5050","28 MDA-MB-231 GSK 1 uM":"","31 MDA-MB-231 GSK 1 uM":"","27 MDA-MB-231 DMM 5 mM":"","30 MDA-MB-231 DMM 5 mM":"","29 MDA-MB-231 Combination":"","32 MDA-MB-231 Combination":"","04 MDA-MB-468 GSK 1 uM":"","07 MDA-MB-468 GSK 1 uM":"","03 MDA-MB-468 DMM 5 mM":"","06 MDA-MB-468 DMM 5 mM":"","05 MDA-MB-468 Combination":"","08 MDA-MB-468 Combination":"","01 Blank":"","46 Blank":"","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"159.8209","10 SUM159PT GSK 1 uM":"","13 SUM159PT GSK 1 uM":"","09 SUM159PT DMM 5 mM":"","12 SUM159PT DMM 5 mM":"","11 SUM159PT Combination":"","14 SUM159PT Combination":""},{"Metabolite":"TVB-2640 412","40 CAL120 GSK 1 uM":"","43 CAL120 GSK 1 uM":"850.5579","39 CAL120 DMM 5 mM":"196.1782","42 CAL120 DMM 5 mM":"193.3924","41 CAL120 Combination":"403.7643","44 CAL120 Combination":"201.6049","22 HCC1806 GSK 1 uM":"","25 HCC1806 GSK 1 uM":"188.6850","21 HCC1806 DMM 5 mM":"","24 HCC1806 DMM 5 mM":"323.8189","23 HCC1806 Combination":"322.6459","26 HCC1806 Combination":"424.9869","34 HS578T GSK 1 uM":"482.7829","37 HS578T GSK 1 uM":"198.2885","33 HS578T DMM 5 mM":"188.5408","36 HS578T DMM 5 mM":"326.6494","35 HS578T Combination":"789.1569","38 HS578T Combination":"324.9653","16 MCF7 GSK 1 uM":"","19 MCF7 GSK 1 uM":"354.6090","15 MCF7 DMM 5 mM":"313.7494","18 MCF7 DMM 5 mM":"207.7152","17 MCF7 Combination":"483.3634","20 MCF7 Combination":"528.5358","28 MDA-MB-231 GSK 1 uM":"517.6145","31 MDA-MB-231 GSK 1 uM":"384.5490","27 MDA-MB-231 DMM 5 mM":"311.0296","30 MDA-MB-231 DMM 5 mM":"322.6184","29 MDA-MB-231 Combination":"327.1864","32 MDA-MB-231 Combination":"162.7575","04 MDA-MB-468 GSK 1 uM":"615.5693","07 MDA-MB-468 GSK 1 uM":"215.8721","03 MDA-MB-468 DMM 5 mM":"329.2537","06 MDA-MB-468 DMM 5 mM":"479.4673","05 MDA-MB-468 Combination":"654.5091","08 MDA-MB-468 Combination":"156.1832","01 Blank":"495.4666","46 Blank":"488.2775","02 DMEM/F12 no adds":"394.4892","45 DMEM/F12 no adds":"422.8550","10 SUM159PT GSK 1 uM":"974.0895","13 SUM159PT GSK 1 uM":"647.8680","09 SUM159PT DMM 5 mM":"","12 SUM159PT DMM 5 mM":"568.8757","11 SUM159PT Combination":"","14 SUM159PT Combination":"200.2446"},{"Metabolite":"TVB-3166 116","40 CAL120 GSK 1 uM":"4840.5901","43 CAL120 GSK 1 uM":"6391.1631","39 CAL120 DMM 5 mM":"2643.0651","42 CAL120 DMM 5 mM":"3368.3269","41 CAL120 Combination":"4429.5701","44 CAL120 Combination":"2851.6887","22 HCC1806 GSK 1 uM":"3339.5451","25 HCC1806 GSK 1 uM":"3956.7213","21 HCC1806 DMM 5 mM":"3539.7883","24 HCC1806 DMM 5 mM":"4753.6533","23 HCC1806 Combination":"4011.5103","26 HCC1806 Combination":"3241.9322","34 HS578T GSK 1 uM":"3810.4427","37 HS578T GSK 1 uM":"3479.1228","33 HS578T DMM 5 mM":"12877.1799","36 HS578T DMM 5 mM":"8225.5095","35 HS578T Combination":"4793.1502","38 HS578T Combination":"1643.0117","16 MCF7 GSK 1 uM":"1991.5389","19 MCF7 GSK 1 uM":"4358.8719","15 MCF7 DMM 5 mM":"4188.3152","18 MCF7 DMM 5 mM":"9325.1295","17 MCF7 Combination":"3607.0637","20 MCF7 Combination":"3409.5037","28 MDA-MB-231 GSK 1 uM":"5113.6699","31 MDA-MB-231 GSK 1 uM":"3764.3936","27 MDA-MB-231 DMM 5 mM":"8992.9981","30 MDA-MB-231 DMM 5 mM":"7713.3646","29 MDA-MB-231 Combination":"9727.5575","32 MDA-MB-231 Combination":"5117.9054","04 MDA-MB-468 GSK 1 uM":"9346.5802","07 MDA-MB-468 GSK 1 uM":"2010.2582","03 MDA-MB-468 DMM 5 mM":"10644.4622","06 MDA-MB-468 DMM 5 mM":"3741.4198","05 MDA-MB-468 Combination":"6923.0282","08 MDA-MB-468 Combination":"3908.5862","01 Blank":"4638.8341","46 Blank":"2457.6435","02 DMEM/F12 no adds":"577.1512","45 DMEM/F12 no adds":"659.9414","10 SUM159PT GSK 1 uM":"4223.1470","13 SUM159PT GSK 1 uM":"5724.1712","09 SUM159PT DMM 5 mM":"11826.6944","12 SUM159PT DMM 5 mM":"4191.6148","11 SUM159PT Combination":"6948.8643","14 SUM159PT Combination":"3958.2325"},{"Metabolite":"TVB-3166 342","40 CAL120 GSK 1 uM":"","43 CAL120 GSK 1 uM":"202.5239","39 CAL120 DMM 5 mM":"203.2237","42 CAL120 DMM 5 mM":"324.5422","41 CAL120 Combination":"187.8295","44 CAL120 Combination":"","22 HCC1806 GSK 1 uM":"403.8483","25 HCC1806 GSK 1 uM":"188.9096","21 HCC1806 DMM 5 mM":"775.8054","24 HCC1806 DMM 5 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uM":"312.6955","09 SUM159PT DMM 5 mM":"217.2818","12 SUM159PT DMM 5 mM":"162.2904","11 SUM159PT Combination":"190.0307","14 SUM159PT Combination":"806.2240"},{"Metabolite":"Tyrosine 123","40 CAL120 GSK 1 uM":"16313651.8800","43 CAL120 GSK 1 uM":"14982437.6000","39 CAL120 DMM 5 mM":"11762872.1200","42 CAL120 DMM 5 mM":"15577779.0500","41 CAL120 Combination":"14330033.0000","44 CAL120 Combination":"14594355.6600","22 HCC1806 GSK 1 uM":"45435905.6700","25 HCC1806 GSK 1 uM":"44188120.7000","21 HCC1806 DMM 5 mM":"42744598.9100","24 HCC1806 DMM 5 mM":"49971931.5300","23 HCC1806 Combination":"55679961.5600","26 HCC1806 Combination":"60242520.7300","34 HS578T GSK 1 uM":"23218032.9500","37 HS578T GSK 1 uM":"19457513.9100","33 HS578T DMM 5 mM":"15984106.6500","36 HS578T DMM 5 mM":"20441134.7900","35 HS578T Combination":"18387326.5000","38 HS578T Combination":"18563690.5200","16 MCF7 GSK 1 uM":"23139964.4000","19 MCF7 GSK 1 uM":"28934672.7300","15 MCF7 DMM 5 mM":"29558654.6900","18 MCF7 DMM 5 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CAL120 GSK 1 uM":"18232328.5200","43 CAL120 GSK 1 uM":"19060032.3500","39 CAL120 DMM 5 mM":"14948603.5300","42 CAL120 DMM 5 mM":"18455410.0900","41 CAL120 Combination":"17669411.0700","44 CAL120 Combination":"18565661.2700","22 HCC1806 GSK 1 uM":"54206984.6700","25 HCC1806 GSK 1 uM":"51261567.8800","21 HCC1806 DMM 5 mM":"48859436.6800","24 HCC1806 DMM 5 mM":"60902684.5500","23 HCC1806 Combination":"65964577.8200","26 HCC1806 Combination":"68620989.1000","34 HS578T GSK 1 uM":"27165749.8800","37 HS578T GSK 1 uM":"24419338.4600","33 HS578T DMM 5 mM":"18965146.3200","36 HS578T DMM 5 mM":"22234839.6100","35 HS578T Combination":"21562816.9900","38 HS578T Combination":"23039242.1700","16 MCF7 GSK 1 uM":"28125532.6300","19 MCF7 GSK 1 uM":"33627249.6000","15 MCF7 DMM 5 mM":"37738499.1100","18 MCF7 DMM 5 mM":"35510926.3100","17 MCF7 Combination":"28385862.8100","20 MCF7 Combination":"20326662.9200","28 MDA-MB-231 GSK 1 uM":"19517216.4600","31 MDA-MB-231 GSK 1 uM":"21422261.0400","27 MDA-MB-231 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Combination":"380923.0580","22 HCC1806 GSK 1 uM":"773824.5195","25 HCC1806 GSK 1 uM":"767464.9804","21 HCC1806 DMM 5 mM":"972862.3920","24 HCC1806 DMM 5 mM":"970897.1745","23 HCC1806 Combination":"953603.1270","26 HCC1806 Combination":"1136410.8570","34 HS578T GSK 1 uM":"393113.3963","37 HS578T GSK 1 uM":"516495.3175","33 HS578T DMM 5 mM":"326739.5045","36 HS578T DMM 5 mM":"441448.3795","35 HS578T Combination":"306783.0610","38 HS578T Combination":"237093.8035","16 MCF7 GSK 1 uM":"600696.9155","19 MCF7 GSK 1 uM":"716560.5182","15 MCF7 DMM 5 mM":"579647.3030","18 MCF7 DMM 5 mM":"1080832.5700","17 MCF7 Combination":"768113.8755","20 MCF7 Combination":"1000070.0230","28 MDA-MB-231 GSK 1 uM":"655796.9415","31 MDA-MB-231 GSK 1 uM":"507840.3010","27 MDA-MB-231 DMM 5 mM":"807632.7400","30 MDA-MB-231 DMM 5 mM":"870797.2145","29 MDA-MB-231 Combination":"862207.9825","32 MDA-MB-231 Combination":"986395.1555","04 MDA-MB-468 GSK 1 uM":"497297.2340","07 MDA-MB-468 GSK 1 uM":"452440.7670","03 MDA-MB-468 DMM 5 mM":"666833.7959","06 MDA-MB-468 DMM 5 mM":"393006.8035","05 MDA-MB-468 Combination":"535504.6530","08 MDA-MB-468 Combination":"572866.1465","01 Blank":"742396.8615","46 Blank":"474277.4680","02 DMEM/F12 no adds":"869198.8180","45 DMEM/F12 no adds":"153820.3585","10 SUM159PT GSK 1 uM":"397155.9616","13 SUM159PT GSK 1 uM":"580093.0753","09 SUM159PT DMM 5 mM":"330055.5160","12 SUM159PT DMM 5 mM":"590671.3315","11 SUM159PT Combination":"637746.9975","14 SUM159PT Combination":"582246.7480"},{"Metabolite":"Urea 44","40 CAL120 GSK 1 uM":"3309831.6190","43 CAL120 GSK 1 uM":"2657428.9760","39 CAL120 DMM 5 mM":"2330988.1250","42 CAL120 DMM 5 mM":"1914533.8570","41 CAL120 Combination":"1975521.3600","44 CAL120 Combination":"2637842.3920","22 HCC1806 GSK 1 uM":"3775795.8480","25 HCC1806 GSK 1 uM":"3154905.1610","21 HCC1806 DMM 5 mM":"4763518.1310","24 HCC1806 DMM 5 mM":"2965991.2730","23 HCC1806 Combination":"2792174.0770","26 HCC1806 Combination":"2779876.4330","34 HS578T GSK 1 uM":"1412816.1800","37 HS578T GSK 1 uM":"1708384.0840","33 HS578T DMM 5 mM":"1234533.5950","36 HS578T DMM 5 mM":"1335171.3440","35 HS578T Combination":"2255870.6010","38 HS578T Combination":"1596589.2860","16 MCF7 GSK 1 uM":"2102030.9120","19 MCF7 GSK 1 uM":"3268738.4740","15 MCF7 DMM 5 mM":"2231777.5750","18 MCF7 DMM 5 mM":"3483614.5530","17 MCF7 Combination":"2339385.1740","20 MCF7 Combination":"2287546.1190","28 MDA-MB-231 GSK 1 uM":"2754899.5460","31 MDA-MB-231 GSK 1 uM":"2601826.6180","27 MDA-MB-231 DMM 5 mM":"3279801.8810","30 MDA-MB-231 DMM 5 mM":"2912482.2140","29 MDA-MB-231 Combination":"2535708.5630","32 MDA-MB-231 Combination":"2202714.3870","04 MDA-MB-468 GSK 1 uM":"14665415.1000","07 MDA-MB-468 GSK 1 uM":"15015288.2200","03 MDA-MB-468 DMM 5 mM":"15546172.6000","06 MDA-MB-468 DMM 5 mM":"12827371.5100","05 MDA-MB-468 Combination":"11449993.6400","08 MDA-MB-468 Combination":"14817268.5100","01 Blank":"168816.2539","46 Blank":"206290.2163","02 DMEM/F12 no 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MDA-MB-231 GSK 1 uM":"7160497.7400","31 MDA-MB-231 GSK 1 uM":"6763534.9220","27 MDA-MB-231 DMM 5 mM":"7589593.5540","30 MDA-MB-231 DMM 5 mM":"7892893.3990","29 MDA-MB-231 Combination":"6858540.9220","32 MDA-MB-231 Combination":"6732047.4180","04 MDA-MB-468 GSK 1 uM":"11300628.4200","07 MDA-MB-468 GSK 1 uM":"11671843.8500","03 MDA-MB-468 DMM 5 mM":"14593014.6600","06 MDA-MB-468 DMM 5 mM":"14371911.8600","05 MDA-MB-468 Combination":"12694548.4400","08 MDA-MB-468 Combination":"14753070.2100","01 Blank":"5216.4326","46 Blank":"4552.9029","02 DMEM/F12 no adds":"81300897.6100","45 DMEM/F12 no adds":"79454814.3700","10 SUM159PT GSK 1 uM":"6970340.8300","13 SUM159PT GSK 1 uM":"8930825.1590","09 SUM159PT DMM 5 mM":"8111003.9160","12 SUM159PT DMM 5 mM":"7898242.9140","11 SUM159PT Combination":"8009435.0380","14 SUM159PT Combination":"8545099.5500"},{"Metabolite":"VY-3-135 355","40 CAL120 GSK 1 uM":"2216.7356","43 CAL120 GSK 1 uM":"3260.6525","39 CAL120 DMM 5 mM":"3245.5637","42 CAL120 DMM 5 mM":"2969.1989","41 CAL120 Combination":"1592.2081","44 CAL120 Combination":"2776.5217","22 HCC1806 GSK 1 uM":"574.6254","25 HCC1806 GSK 1 uM":"2206.2840","21 HCC1806 DMM 5 mM":"5803.8061","24 HCC1806 DMM 5 mM":"996.7245","23 HCC1806 Combination":"1118.5921","26 HCC1806 Combination":"390.1426","34 HS578T GSK 1 uM":"1570.4283","37 HS578T GSK 1 uM":"4114.6353","33 HS578T DMM 5 mM":"982.3863","36 HS578T DMM 5 mM":"1167.9125","35 HS578T Combination":"3192.9515","38 HS578T Combination":"647.1029","16 MCF7 GSK 1 uM":"637.5405","19 MCF7 GSK 1 uM":"800.2621","15 MCF7 DMM 5 mM":"1552.2431","18 MCF7 DMM 5 mM":"215.0018","17 MCF7 Combination":"593.1136","20 MCF7 Combination":"1186.1633","28 MDA-MB-231 GSK 1 uM":"1048.0898","31 MDA-MB-231 GSK 1 uM":"1142.9798","27 MDA-MB-231 DMM 5 mM":"3663.0862","30 MDA-MB-231 DMM 5 mM":"2223.7077","29 MDA-MB-231 Combination":"1520.1107","32 MDA-MB-231 Combination":"1132.9170","04 MDA-MB-468 GSK 1 uM":"690.6836","07 MDA-MB-468 GSK 1 uM":"1133.3922","03 MDA-MB-468 DMM 5 mM":"608.3381","06 MDA-MB-468 DMM 5 mM":"2300.1979","05 MDA-MB-468 Combination":"1339.2464","08 MDA-MB-468 Combination":"794.3481","01 Blank":"","46 Blank":"196.2213","02 DMEM/F12 no adds":"","45 DMEM/F12 no adds":"639.2835","10 SUM159PT GSK 1 uM":"3321.2863","13 SUM159PT GSK 1 uM":"1572.8273","09 SUM159PT DMM 5 mM":"2618.2643","12 SUM159PT DMM 5 mM":"556.5680","11 SUM159PT Combination":"833.9838","14 SUM159PT Combination":"1005.7524"},{"Metabolite":"VY-3-135 412","40 CAL120 GSK 1 uM":"87538.7910","43 CAL120 GSK 1 uM":"84771.9690","39 CAL120 DMM 5 mM":"107225.0439","42 CAL120 DMM 5 mM":"112385.6727","41 CAL120 Combination":"113448.1704","44 CAL120 Combination":"53138.4723","22 HCC1806 GSK 1 uM":"24560.5342","25 HCC1806 GSK 1 uM":"22895.9869","21 HCC1806 DMM 5 mM":"94833.8904","24 HCC1806 DMM 5 mM":"78746.8965","23 HCC1806 Combination":"53758.1411","26 HCC1806 Combination":"21551.4570","34 HS578T GSK 1 uM":"88492.0544","37 HS578T GSK 1 uM":"105256.2914","33 HS578T DMM 5 mM":"115226.6147","36 HS578T DMM 5 mM":"115585.6664","35 HS578T Combination":"95529.1008","38 HS578T Combination":"14886.1304","16 MCF7 GSK 1 uM":"32977.6850","19 MCF7 GSK 1 uM":"27352.9885","15 MCF7 DMM 5 mM":"17857.1398","18 MCF7 DMM 5 mM":"28262.1644","17 MCF7 Combination":"18853.4808","20 MCF7 Combination":"16807.5440","28 MDA-MB-231 GSK 1 uM":"26009.7261","31 MDA-MB-231 GSK 1 uM":"50721.1994","27 MDA-MB-231 DMM 5 mM":"110406.6846","30 MDA-MB-231 DMM 5 mM":"86605.1599","29 MDA-MB-231 Combination":"39270.9241","32 MDA-MB-231 Combination":"43609.8805","04 MDA-MB-468 GSK 1 uM":"54833.9288","07 MDA-MB-468 GSK 1 uM":"25785.3542","03 MDA-MB-468 DMM 5 mM":"24426.8884","06 MDA-MB-468 DMM 5 mM":"65270.4761","05 MDA-MB-468 Combination":"78873.2914","08 MDA-MB-468 Combination":"11138.1797","01 Blank":"1959.2939","46 Blank":"4156.3916","02 DMEM/F12 no adds":"1949.0569","45 DMEM/F12 no adds":"2558.4418","10 SUM159PT GSK 1 uM":"67845.3267","13 SUM159PT GSK 1 uM":"14985.8039","09 SUM159PT DMM 5 mM":"59069.6547","12 SUM159PT DMM 5 mM":"52912.6278","11 SUM159PT Combination":"36881.8050","14 SUM159PT Combination":"53731.9622"},{"Metabolite":"VY-7-137 233","40 CAL120 GSK 1 uM":"324.0463","43 CAL120 GSK 1 uM":"486.7048","39 CAL120 DMM 5 mM":"1444.1109","42 CAL120 DMM 5 mM":"874.2297","41 CAL120 Combination":"1412.5242","44 CAL120 Combination":"573.2750","22 HCC1806 GSK 1 uM":"607.9398","25 HCC1806 GSK 1 uM":"401.7071","21 HCC1806 DMM 5 mM":"428.9302","24 HCC1806 DMM 5 mM":"650.6775","23 HCC1806 Combination":"210.2249","26 HCC1806 Combination":"513.9321","34 HS578T GSK 1 uM":"836.0504","37 HS578T GSK 1 uM":"600.7423","33 HS578T DMM 5 mM":"163.2011","36 HS578T DMM 5 mM":"653.5958","35 HS578T Combination":"509.6736","38 HS578T Combination":"380.3784","16 MCF7 GSK 1 uM":"727.3794","19 MCF7 GSK 1 uM":"428.3626","15 MCF7 DMM 5 mM":"404.9288","18 MCF7 DMM 5 mM":"768.3694","17 MCF7 Combination":"805.7718","20 MCF7 Combination":"332.2372","28 MDA-MB-231 GSK 1 uM":"608.3280","31 MDA-MB-231 GSK 1 uM":"642.8729","27 MDA-MB-231 DMM 5 mM":"1328.9377","30 MDA-MB-231 DMM 5 mM":"484.5663","29 MDA-MB-231 Combination":"803.5169","32 MDA-MB-231 Combination":"378.4355","04 MDA-MB-468 GSK 1 uM":"403.6646","07 MDA-MB-468 GSK 1 uM":"331.8963","03 MDA-MB-468 DMM 5 mM":"428.8839","06 MDA-MB-468 DMM 5 mM":"807.5404","05 MDA-MB-468 Combination":"1126.9101","08 MDA-MB-468 Combination":"1198.3837","01 Blank":"591.2164","46 Blank":"591.7736","02 DMEM/F12 no adds":"376.0637","45 DMEM/F12 no adds":"577.5238","10 SUM159PT GSK 1 uM":"848.9173","13 SUM159PT GSK 1 uM":"976.1433","09 SUM159PT DMM 5 mM":"","12 SUM159PT DMM 5 mM":"605.2288","11 SUM159PT Combination":"494.5688","14 SUM159PT Combination":"1207.8787"},{"Metabolite":"VY-7-137 508","40 CAL120 GSK 1 uM":"39254.4531","43 CAL120 GSK 1 uM":"46194.4361","39 CAL120 DMM 5 mM":"51489.6370","42 CAL120 DMM 5 mM":"49966.6135","41 CAL120 Combination":"55774.1289","44 CAL120 Combination":"41081.4806","22 HCC1806 GSK 1 uM":"20132.6061","25 HCC1806 GSK 1 uM":"19061.0125","21 HCC1806 DMM 5 mM":"18650.6615","24 HCC1806 DMM 5 mM":"19080.9441","23 HCC1806 Combination":"12726.3234","26 HCC1806 Combination":"12827.3938","34 HS578T GSK 1 uM":"77753.0327","37 HS578T GSK 1 uM":"86431.8084","33 HS578T DMM 5 mM":"92147.4283","36 HS578T DMM 5 mM":"66038.7032","35 HS578T Combination":"89134.5252","38 HS578T Combination":"73046.2358","16 MCF7 GSK 1 uM":"19900.8152","19 MCF7 GSK 1 uM":"31521.3248","15 MCF7 DMM 5 mM":"31587.8470","18 MCF7 DMM 5 mM":"37276.3379","17 MCF7 Combination":"29149.1607","20 MCF7 Combination":"23306.4437","28 MDA-MB-231 GSK 1 uM":"63600.5138","31 MDA-MB-231 GSK 1 uM":"63424.0600","27 MDA-MB-231 DMM 5 mM":"83803.0155","30 MDA-MB-231 DMM 5 mM":"93198.3801","29 MDA-MB-231 Combination":"75863.3903","32 MDA-MB-231 Combination":"70685.5544","04 MDA-MB-468 GSK 1 uM":"35465.8661","07 MDA-MB-468 GSK 1 uM":"43089.1508","03 MDA-MB-468 DMM 5 mM":"53081.2094","06 MDA-MB-468 DMM 5 mM":"64652.1264","05 MDA-MB-468 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}

}