{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000191","ANALYSIS_ID":"AN000293","VERSION":"1","CREATED_ON":"2016-09-17"},

"PROJECT":{"PROJECT_TITLE":"Neurogenic Hypertension","PROJECT_SUMMARY":"Role of neuroinflammation and microbiome in drug-resistant hypertension","INSTITUTE":"University of Florida","DEPARTMENT":"Physiology & Functional Genomics","LABORATORY":"Raizada Lab","LAST_NAME":"Raizada","FIRST_NAME":"Mohan","ADDRESS":"Gainesville, FL","EMAIL":"mraizada@ufl.edu","PHONE":"352-392-9299"},

"STUDY":{"STUDY_TITLE":"SCFA in Hypertension","STUDY_TYPE":"Samples 4-34 are sera and feces from an experiment to determine the effects of on SCFA in Ang II-induced hypertension. Samples 35-59 are plasma samples fron experiment to determine the effects of ACE2 activator, DIZE on SCFA in pulmonary hypertension. Plasma samples were collected using heparin","STUDY_SUMMARY":"Samples 4-34 are sera and feces from an experiment to determine the effects of on SCFA in Ang II-induced hypertension. Samples 35-59 are plasma samples fron experiment to determine the effects of ACE2 activator, DIZE on SCFA in pulmonary hypertension. Plasma samples were collected using heparin","INSTITUTE":"University of Michigan","DEPARTMENT":"Biomedical Research Core Facilities","LABORATORY":"Metabolomics core","LAST_NAME":"Kachman","FIRST_NAME":"Maureen","ADDRESS":"6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714","EMAIL":"mkachman@umich.edu","PHONE":"-","NUM_GROUPS":"7","TOTAL_SUBJECTS":"56"},

"SUBJECT":{"SUBJECT_TYPE":"-","SUBJECT_SPECIES":"Rattus norvegicus","TAXONOMY_ID":"10114"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"SU0004856",
"Sample ID":"S00015896",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015897",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015898",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015899",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015912",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015913",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015914",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015915",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015928",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015929",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015930",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015931",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015932",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004856",
"Sample ID":"S00015933",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004862",
"Sample ID":"S00015946",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"Y"}
},
{
"Subject ID":"SU0004862",
"Sample ID":"S00015947",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"Y"}
},
{
"Subject ID":"SU0004862",
"Sample ID":"S00015948",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"Y"}
},
{
"Subject ID":"SU0004862",
"Sample ID":"S00015949",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"Y"}
},
{
"Subject ID":"SU0004862",
"Sample ID":"S00015950",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"Y"}
},
{
"Subject ID":"SU0004862",
"Sample ID":"S00015951",
"Factors":{"Ang II":"N","Mino":"N","MCT":"N","DIZE":"Y"}
},
{
"Subject ID":"SU0004860",
"Sample ID":"S00015934",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"N"}
},
{
"Subject ID":"SU0004860",
"Sample ID":"S00015935",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"N"}
},
{
"Subject ID":"SU0004860",
"Sample ID":"S00015936",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"N"}
},
{
"Subject ID":"SU0004860",
"Sample ID":"S00015937",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"N"}
},
{
"Subject ID":"SU0004860",
"Sample ID":"S00015938",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"N"}
},
{
"Subject ID":"SU0004860",
"Sample ID":"S00015939",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"N"}
},
{
"Subject ID":"SU0004861",
"Sample ID":"S00015940",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"Y"}
},
{
"Subject ID":"SU0004861",
"Sample ID":"S00015941",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"Y"}
},
{
"Subject ID":"SU0004861",
"Sample ID":"S00015942",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"Y"}
},
{
"Subject ID":"SU0004861",
"Sample ID":"S00015943",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"Y"}
},
{
"Subject ID":"SU0004861",
"Sample ID":"S00015944",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"Y"}
},
{
"Subject ID":"SU0004861",
"Sample ID":"S00015945",
"Factors":{"Ang II":"N","Mino":"N","MCT":"Y","DIZE":"Y"}
},
{
"Subject ID":"SU0004859",
"Sample ID":"S00015908",
"Factors":{"Ang II":"N","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004859",
"Sample ID":"S00015909",
"Factors":{"Ang II":"N","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004859",
"Sample ID":"S00015910",
"Factors":{"Ang II":"N","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004859",
"Sample ID":"S00015911",
"Factors":{"Ang II":"N","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004859",
"Sample ID":"S00015924",
"Factors":{"Ang II":"N","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004859",
"Sample ID":"S00015925",
"Factors":{"Ang II":"N","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004859",
"Sample ID":"S00015926",
"Factors":{"Ang II":"N","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004859",
"Sample ID":"S00015927",
"Factors":{"Ang II":"N","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004857",
"Sample ID":"S00015900",
"Factors":{"Ang II":"Y","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004857",
"Sample ID":"S00015901",
"Factors":{"Ang II":"Y","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004857",
"Sample ID":"S00015902",
"Factors":{"Ang II":"Y","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004857",
"Sample ID":"S00015903",
"Factors":{"Ang II":"Y","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004857",
"Sample ID":"S00015916",
"Factors":{"Ang II":"Y","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004857",
"Sample ID":"S00015917",
"Factors":{"Ang II":"Y","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004857",
"Sample ID":"S00015918",
"Factors":{"Ang II":"Y","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004857",
"Sample ID":"S00015919",
"Factors":{"Ang II":"Y","Mino":"N","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004858",
"Sample ID":"S00015904",
"Factors":{"Ang II":"Y","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004858",
"Sample ID":"S00015905",
"Factors":{"Ang II":"Y","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004858",
"Sample ID":"S00015906",
"Factors":{"Ang II":"Y","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004858",
"Sample ID":"S00015907",
"Factors":{"Ang II":"Y","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004858",
"Sample ID":"S00015920",
"Factors":{"Ang II":"Y","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004858",
"Sample ID":"S00015921",
"Factors":{"Ang II":"Y","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004858",
"Sample ID":"S00015922",
"Factors":{"Ang II":"Y","Mino":"Y","MCT":"N","DIZE":"N"}
},
{
"Subject ID":"SU0004858",
"Sample ID":"S00015923",
"Factors":{"Ang II":"Y","Mino":"Y","MCT":"N","DIZE":"N"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"-","SAMPLE_TYPE":"Serum"},

"TREATMENT":{"TREATMENT_SUMMARY":"-"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"-","SAMPLEPREP_PROTOCOL_FILENAME":"SCFA_analysis_protocol-2015-03-10.docx"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"-","COLUMN_NAME":"Phenomenex Zebron ZB-WAXplus (30m x 0.25mm, 0.25um)","METHODS_ID":"AQM030","METHODS_FILENAME":"WAXPLUS_100-200C_2_SIM.txt"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","LABORATORY_NAME":"MRC2 (University of Michigan)","ACQUISITION_PARAMETERS_FILE":"WAXPLUS_100-200C_2_SIM.txt","PROCESSING_PARAMETERS_FILE":"EX00350-SCFA-Quant-methods-plasma.m.zip"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 5975C","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"EI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"pmol/mg sample",

"Data":[{"Metabolite":"aceticacid","S00015912":"9670.4680","S00015913":"27676.4560","S00015914":"10650.6960","S00015915":"12842.0180","S00015924":"6834.3830","S00015925":"3483.8260","S00015926":"135.7560","S00015927":"551.9060","S00015916":"9281.4160","S00015917":"9142.5730","S00015918":"16704.1060","S00015919":"7789.5520","S00015920":"9440.9310","S00015921":"7754.2400","S00015922":"10059.1710","S00015923":"14831.4040"},{"Metabolite":"butyricacid","S00015912":"9147.4690","S00015913":"9043.4340","S00015914":"17616.4000","S00015915":"21983.3100","S00015924":"4670.5050","S00015925":"18116.9990","S00015926":"2905.5530","S00015927":"1475.3960","S00015916":"16392.4080","S00015917":"5807.7600","S00015918":"9913.1420","S00015919":"12044.0480","S00015920":"1802.1990","S00015921":"8620.9060","S00015922":"11003.2970","S00015923":"10452.5680"},{"Metabolite":"hexanoicacid","S00015912":"21.8680","S00015913":"21.6780","S00015914":"22.7170","S00015915":"1420.2370","S00015924":"14.7520","S00015925":"15.5250","S00015926":"10.8720","S00015927":"5.8760","S00015916":"50.0710","S00015917":"19.5920","S00015918":"425.9030","S00015919":"21.0250","S00015920":"0.0000","S00015921":"20.2700","S00015922":"39.8100","S00015923":"23.9030"},{"Metabolite":"iso-butyricacid","S00015912":"533.6300","S00015913":"300.6870","S00015914":"467.5590","S00015915":"807.1930","S00015924":"400.0370","S00015925":"786.3830","S00015926":"215.5700","S00015927":"157.8210","S00015916":"443.0000","S00015917":"449.6510","S00015918":"495.6440","S00015919":"264.0620","S00015920":"55.5200","S00015921":"272.9260","S00015922":"723.5280","S00015923":"758.1930"},{"Metabolite":"isovalericacid","S00015912":"615.4020","S00015913":"196.1300","S00015914":"486.1400","S00015915":"763.8810","S00015924":"379.5920","S00015925":"674.7490","S00015926":"221.3150","S00015927":"143.7320","S00015916":"351.7400","S00015917":"380.2220","S00015918":"231.5830","S00015919":"264.2630","S00015920":"58.4280","S00015921":"272.2000","S00015922":"510.5560","S00015923":"697.8440"},{"Metabolite":"propionic acid","S00015912":"3431.9930","S00015913":"5560.5580","S00015914":"4874.8990","S00015915":"4072.0130","S00015924":"3724.2510","S00015925":"7094.9150","S00015926":"3371.1580","S00015927":"3474.9910","S00015916":"3788.1600","S00015917":"2035.7540","S00015918":"5337.4930","S00015919":"1990.9590","S00015920":"2682.4610","S00015921":"3069.4800","S00015922":"3820.8580","S00015923":"4101.4260"},{"Metabolite":"valericacid","S00015912":"1748.2140","S00015913":"370.6530","S00015914":"1534.3530","S00015915":"1808.3970","S00015924":"993.1450","S00015925":"2747.0810","S00015926":"726.0250","S00015927":"185.1560","S00015916":"475.4910","S00015917":"959.9700","S00015918":"889.0730","S00015919":"1169.0280","S00015920":"421.7970","S00015921":"1129.5980","S00015922":"1109.5650","S00015923":"1907.0970"}],

"Metabolites":[{"Metabolite":"aceticacid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"176","inchi_key":"","kegg_id":"","other_id":"Acetate","other_id_type":"UM_Target_ID"},{"Metabolite":"butyricacid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"20975673","inchi_key":"","kegg_id":"","other_id":"Butyrate","other_id_type":"UM_Target_ID"},{"Metabolite":"hexanoicacid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"8892","inchi_key":"","kegg_id":"","other_id":"Hexanoate","other_id_type":"UM_Target_ID"},{"Metabolite":"iso-butyricacid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"6590","inchi_key":"","kegg_id":"","other_id":"iso-butyrate","other_id_type":"UM_Target_ID"},{"Metabolite":"isovalericacid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"10430","inchi_key":"","kegg_id":"","other_id":"Isovalerate","other_id_type":"UM_Target_ID"},{"Metabolite":"propionic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"1032","inchi_key":"","kegg_id":"","other_id":"Propionate","other_id_type":"UM_Target_ID"},{"Metabolite":"valericacid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"7991","inchi_key":"","kegg_id":"","other_id":"Valerate","other_id_type":"UM_Target_ID"}]
}

}