{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000199","ANALYSIS_ID":"AN000301","VERSION":"1","CREATED_ON":"2016-09-17"},

"PROJECT":{"PROJECT_TITLE":"IDH1 and Glioma","PROJECT_SUMMARY":"IDH1 is overexpresed in gliomas and knockdown of IDH1 leads to increased therapy-induced cell death","INSTITUTE":"Northwestern University","DEPARTMENT":"Neurology","LABORATORY":"Stegh Lab","LAST_NAME":"Stegh","FIRST_NAME":"Alexander","ADDRESS":"Evanston, IL","EMAIL":"a-stegh@northwestern.edu","PHONE":"312-503-2879"},

"STUDY":{"STUDY_TITLE":"IDH1 and Glioma knockdown idh1 (part II)","STUDY_SUMMARY":"Tumor neurospheres were grown in culture until 90% confluent. To collect cells, were filtered through 0.45um nylon filters (Fischer Sci 099029) that were with methanol and ultrapure water using a microanalytical glass filter holder Sci 09753E). The cells were filtered through filtration apparatus, then washed 1mL of distilled water very quickly. Filter paper is taken immediatedly with and plunged cell side down into 6-well plate filled with liquid nitrogen placed dry ice. Plate is wrapped in aluminum foil and stored at -80C before the liquid evaporates. Samples are shipped on dry ice","INSTITUTE":"University of Michigan","DEPARTMENT":"Biomedical Research Core Facilities","LABORATORY":"Metabolomics core","LAST_NAME":"Kachman","FIRST_NAME":"Maureen","ADDRESS":"6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714","EMAIL":"mkachman@umich.edu","PHONE":"-","NUM_GROUPS":"2","TOTAL_SUBJECTS":"10"},

"SUBJECT":{"SUBJECT_TYPE":"-","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"SU0004254",
"Sample ID":"S00014999",
"Factors":{"Knockdown of IDH1":"n/a"}
},
{
"Subject ID":"SU0004254",
"Sample ID":"S00015000",
"Factors":{"Knockdown of IDH1":"n/a"}
},
{
"Subject ID":"SU0004254",
"Sample ID":"S00015001",
"Factors":{"Knockdown of IDH1":"n/a"}
},
{
"Subject ID":"SU0004254",
"Sample ID":"S00015002",
"Factors":{"Knockdown of IDH1":"n/a"}
},
{
"Subject ID":"SU0004254",
"Sample ID":"S00015003",
"Factors":{"Knockdown of IDH1":"n/a"}
},
{
"Subject ID":"SU0004254",
"Sample ID":"S00015004",
"Factors":{"Knockdown of IDH1":"yes"}
},
{
"Subject ID":"SU0004254",
"Sample ID":"S00015005",
"Factors":{"Knockdown of IDH1":"yes"}
},
{
"Subject ID":"SU0004254",
"Sample ID":"S00015006",
"Factors":{"Knockdown of IDH1":"yes"}
},
{
"Subject ID":"SU0004254",
"Sample ID":"S00015007",
"Factors":{"Knockdown of IDH1":"yes"}
},
{
"Subject ID":"SU0004254",
"Sample ID":"S00015008",
"Factors":{"Knockdown of IDH1":"yes"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"-","SAMPLE_TYPE":"Cells, Cultured"},

"TREATMENT":{"TREATMENT_SUMMARY":"-"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"-","SAMPLEPREP_PROTOCOL_FILENAME":"Acyl-carnitines_analysis_protocol-CR-MK-20150528.docx"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Agilent 1200","COLUMN_NAME":"Waters Acquity HSS T3 (50 x 2.1mm, 1.8um)","METHODS_ID":"AQM050","METHODS_FILENAME":"QM-004-Xbridg2mm_ACar+_MRM-Insert.m.zip"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","LABORATORY_NAME":"MRC2 (University of Michigan)","ACQUISITION_PARAMETERS_FILE":"QM-004-Xbridg2mm_ACar+_MRM-Insert.m.zip","PROCESSING_PARAMETERS_FILE":"EX00311-acyl-carnitines-quant.m.zip"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 6490 QQQ","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"pmol/µg protein",

"Data":[{"Metabolite":"3-hydroxylauroylcarnitine","S00014999":"0.0008","S00015000":"0.0007","S00015001":"0.0013","S00015002":"0.0008","S00015003":"0.0001","S00015004":"0.0011","S00015005":"0.0010","S00015006":"0.0030","S00015007":"0.0024","S00015008":"0.0022"},{"Metabolite":"3-Hydroxylinoleoylcarnitine","S00014999":"0.1148","S00015000":"0.0852","S00015001":"0.1639","S00015002":"0.0799","S00015003":"0.0826","S00015004":"0.1672","S00015005":"0.0939","S00015006":"0.2873","S00015007":"0.1910","S00015008":"0.1956"},{"Metabolite":"3-hydroxymyristoylcarnitine","S00014999":"0.0060","S00015000":"0.0050","S00015001":"0.0056","S00015002":"0.0027","S00015003":"0.0034","S00015004":"0.0084","S00015005":"0.0049","S00015006":"0.0138","S00015007":"0.0095","S00015008":"0.0078"},{"Metabolite":"3-Hydroxypalmitoylcarnitine","S00014999":"0.0146","S00015000":"0.0090","S00015001":"0.0134","S00015002":"0.0069","S00015003":"0.0084","S00015004":"0.0133","S00015005":"0.0066","S00015006":"0.0216","S00015007":"0.0126","S00015008":"0.0135"},{"Metabolite":"Acetylcarnitine","S00014999":"19.8971","S00015000":"16.4317","S00015001":"22.5422","S00015002":"16.5401","S00015003":"12.9806","S00015004":"81.2444","S00015005":"44.0475","S00015006":"79.8879","S00015007":"64.3582","S00015008":"61.5523"},{"Metabolite":"arachidonoylcarnitine","S00014999":"0.0018","S00015000":"0.0008","S00015001":"0.0020","S00015002":"0.0024","S00015003":"0.0010","S00015004":"0.0203","S00015005":"0.0012","S00015006":"0.0026","S00015007":"0.0039","S00015008":"0.0021"},{"Metabolite":"butyrylcarnitine","S00014999":"0.3544","S00015000":"0.2994","S00015001":"0.4361","S00015002":"0.2922","S00015003":"0.2454","S00015004":"0.6995","S00015005":"0.3850","S00015006":"0.7448","S00015007":"0.5552","S00015008":"0.5307"},{"Metabolite":"Decanoylcarnitine","S00014999":"0.0072","S00015000":"0.0087","S00015001":"0.0119","S00015002":"0.0072","S00015003":"0.0081","S00015004":"0.0103","S00015005":"0.0062","S00015006":"0.0139","S00015007":"0.0099","S00015008":"0.0138"},{"Metabolite":"decenoylcarnitine","S00014999":"0.0000","S00015000":"0.0000","S00015001":"0.0000","S00015002":"0.0000","S00015003":"0.0000","S00015004":"0.0000","S00015005":"0.0000","S00015006":"0.0000","S00015007":"0.0000","S00015008":"0.0000"},{"Metabolite":"Dodecenoylcarnitine","S00014999":"0.0073","S00015000":"0.0059","S00015001":"0.0100","S00015002":"0.0050","S00015003":"0.0058","S00015004":"0.0103","S00015005":"0.0073","S00015006":"0.0116","S00015007":"0.0101","S00015008":"0.0121"},{"Metabolite":"Glutarylcarnitine","S00014999":"0.0038","S00015000":"0.0016","S00015001":"0.0016","S00015002":"0.0035","S00015003":"0.0013","S00015004":"0.0053","S00015005":"0.0017","S00015006":"0.0071","S00015007":"0.0049","S00015008":"0.0047"},{"Metabolite":"Hexanoylcarnitine","S00014999":"0.0027","S00015000":"0.0044","S00015001":"0.0064","S00015002":"0.0030","S00015003":"0.0034","S00015004":"0.0145","S00015005":"0.0033","S00015006":"0.0237","S00015007":"0.0128","S00015008":"0.0164"},{"Metabolite":"icosadienoylcarnitine","S00014999":"0.0007","S00015000":"0.0001","S00015001":"0.0005","S00015002":"0.0001","S00015003":"0.0000","S00015004":"0.0003","S00015005":"0.0003","S00015006":"0.0004","S00015007":"0.0004","S00015008":"0.0001"},{"Metabolite":"Icosanoylcarnitine","S00014999":"0.0000","S00015000":"0.0000","S00015001":"0.0000","S00015002":"0.0000","S00015003":"0.0000","S00015004":"0.0000","S00015005":"0.0000","S00015006":"0.0000","S00015007":"0.0000","S00015008":"0.0000"},{"Metabolite":"icosatrienoylcarnitine","S00014999":"0.0650","S00015000":"0.0699","S00015001":"0.0743","S00015002":"0.0361","S00015003":"0.0618","S00015004":"0.1061","S00015005":"0.0891","S00015006":"0.4644","S00015007":"0.1931","S00015008":"0.2635"},{"Metabolite":"icoseneoylcarnitine","S00014999":"0.0098","S00015000":"0.0085","S00015001":"0.0081","S00015002":"0.0045","S00015003":"0.0069","S00015004":"0.0169","S00015005":"0.0127","S00015006":"0.0627","S00015007":"0.0261","S00015008":"0.0347"},{"Metabolite":"isovalerylcarnitine","S00014999":"0.2867","S00015000":"0.2230","S00015001":"0.3100","S00015002":"0.2204","S00015003":"0.1707","S00015004":"0.1962","S00015005":"0.1227","S00015006":"0.2027","S00015007":"0.1892","S00015008":"0.1721"},{"Metabolite":"lauroylcarnitine","S00014999":"0.0000","S00015000":"0.0008","S00015001":"0.0002","S00015002":"0.0001","S00015003":"0.0003","S00015004":"0.0009","S00015005":"0.0001","S00015006":"0.0001","S00015007":"0.0005","S00015008":"0.0005"},{"Metabolite":"L-Carnitine","S00014999":"34.2595","S00015000":"25.9039","S00015001":"34.0476","S00015002":"21.3902","S00015003":"23.9979","S00015004":"37.5044","S00015005":"21.0793","S00015006":"44.7552","S00015007":"34.0823","S00015008":"35.5254"},{"Metabolite":"Linoelaidyl 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}

}