{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000233","ANALYSIS_ID":"AN000350","VERSION":"1","CREATED_ON":"2016-09-17"},

"PROJECT":{"PROJECT_TITLE":"Aryl Hydrocarbon Receptor Activation by Persistent Organic Pollutants Impacts Microbiota-Host Metabolic Homeostasis in Mice","PROJECT_SUMMARY":"-","INSTITUTE":"Pennsylvania State University","DEPARTMENT":"Molecular Toxicology","LAST_NAME":"Andrew","FIRST_NAME":"Patterson","ADDRESS":"-","EMAIL":"adp117@PSU.EDU, RGN5011@psu.edu","PHONE":"-"},

"STUDY":{"STUDY_TITLE":"Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Induces Systemic Metabolic Dysfunction in Mice (Part II)","STUDY_TYPE":"Time course","STUDY_SUMMARY":"12 C57BL/6J male mice were acclimatized for 1 week and then divided into two and trained to eat dough pills. One group was control and the other was exposed TCDF through the dough pills. The mice were treated for 5 days at a dosage of TCDF for a final concentration of 5μg/kg body weight. Also looked at were mice and they were treated the same way as the C57BL/6J mice.","INSTITUTE":"Pennsylvania State University","DEPARTMENT":"Department of Veterinary and Biomedical Sciences","LAST_NAME":"Patterson","FIRST_NAME":"Andrew","ADDRESS":"101 Life Sciences, University Park, State college, 16802","EMAIL":"rgn5011@psu.edu","PHONE":"-"},

"SUBJECT":{"SUBJECT_TYPE":"Mouse","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENOTYPE_STRAIN":"C57BL/6J"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"Mouse",
"Sample ID":"101",
"Factors":{"Strain":"AHR -/-","Treatment":"Control"}
},
{
"Subject ID":"Mouse",
"Sample ID":"102",
"Factors":{"Strain":"AHR -/-","Treatment":"Control"}
},
{
"Subject ID":"Mouse",
"Sample ID":"103",
"Factors":{"Strain":"AHR -/-","Treatment":"Control"}
},
{
"Subject ID":"Mouse",
"Sample ID":"104",
"Factors":{"Strain":"AHR -/-","Treatment":"Control"}
},
{
"Subject ID":"Mouse",
"Sample ID":"105",
"Factors":{"Strain":"AHR -/-","Treatment":"Control"}
},
{
"Subject ID":"Mouse",
"Sample ID":"201",
"Factors":{"Strain":"AHR -/-","Treatment":"TCDF Treatment"}
},
{
"Subject ID":"Mouse",
"Sample ID":"202",
"Factors":{"Strain":"AHR -/-","Treatment":"TCDF Treatment"}
},
{
"Subject ID":"Mouse",
"Sample ID":"203",
"Factors":{"Strain":"AHR -/-","Treatment":"TCDF Treatment"}
},
{
"Subject ID":"Mouse",
"Sample ID":"204",
"Factors":{"Strain":"AHR -/-","Treatment":"TCDF Treatment"}
},
{
"Subject ID":"Mouse",
"Sample ID":"205",
"Factors":{"Strain":"AHR -/-","Treatment":"TCDF Treatment"}
},
{
"Subject ID":"Mouse",
"Sample ID":"301",
"Factors":{"Strain":"WT","Treatment":"Control"}
},
{
"Subject ID":"Mouse",
"Sample ID":"302",
"Factors":{"Strain":"WT","Treatment":"Control"}
},
{
"Subject ID":"Mouse",
"Sample ID":"303",
"Factors":{"Strain":"WT","Treatment":"Control"}
},
{
"Subject ID":"Mouse",
"Sample ID":"304",
"Factors":{"Strain":"WT","Treatment":"Control"}
},
{
"Subject ID":"Mouse",
"Sample ID":"305",
"Factors":{"Strain":"WT","Treatment":"Control"}
},
{
"Subject ID":"Mouse",
"Sample ID":"401",
"Factors":{"Strain":"WT","Treatment":"TCDF Treatment"}
},
{
"Subject ID":"Mouse",
"Sample ID":"402",
"Factors":{"Strain":"WT","Treatment":"TCDF Treatment"}
},
{
"Subject ID":"Mouse",
"Sample ID":"403",
"Factors":{"Strain":"WT","Treatment":"TCDF Treatment"}
},
{
"Subject ID":"Mouse",
"Sample ID":"405",
"Factors":{"Strain":"WT","Treatment":"TCDF Treatment"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Feces and urine were collected every other day. Then Liver, blood and tissue were collected after death","SAMPLE_TYPE":"Feces, Urine, Liver, Blood, Intestinal tissue"},

"TREATMENT":{"TREATMENT_SUMMARY":"-"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"-","SAMPLEPREP_PROTOCOL_FILENAME":"GC_Sample_Prep.docx","PROCESSING_METHOD":"Homogenization","EXTRACTION_METHOD":"Methanol-Chloroform","EXTRACT_ENRICHMENT":"centerfugation","EXTRACT_CLEANUP":"bottom layer was dried with N2 gas, resuspended in MEOH/HCL and then hexane and top layer was collected","SAMPLE_RESUSPENSION":"resuspended in hexane","SAMPLE_SPIKING":"C15:0 free acid and methy ester of C17:0 at 5 ?L","ORGAN":"Liver"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"-","COLUMN_NAME":"-"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 5975C","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"EI","ION_MODE":"POSITIVE","MS_COMMENTS":"Liver"},

"MS_METABOLITE_DATA":{
"Units":"Peak area",

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}

}