{ "METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000283","ANALYSIS_ID":"AN000451","VERSION":"1","CREATED_ON":"2016-09-17"}, "PROJECT":{"PROJECT_TITLE":"Human AxP Studies","PROJECT_TYPE":"Glycolysis/TCA/Nucleotide analysis (tissue/cells)","PROJECT_SUMMARY":"Plasma Nucleotide/adenosine concentrations","INSTITUTE":"University of Michigan","DEPARTMENT":"Internal Medicine-Cardiology","LABORATORY":"Visovatti Lab","LAST_NAME":"Visovatti","FIRST_NAME":"Scott","ADDRESS":"Ann Arbor, MI","EMAIL":"shv@med.umich.edu","PHONE":"734-657-6917"}, "STUDY":{"STUDY_TITLE":"Plasma Nucleotide/adenosine concentrations (Human AxP Batch 4)","STUDY_TYPE":"Glycolysis/TCA/Nucleotide analysis (tissue/cells)","STUDY_SUMMARY":"This experiment was performed using the following cohorts: 1) healthy controls, patients with scleroderma at low risk for pulmonary hypertension, 3) pateints scleroderma at high risk for pulmonary hypertension. Whole blood was drawn into stop soilution (1:1 ratio) at rest and again at peak exercise for each subject.","INSTITUTE":"University of Michigan","DEPARTMENT":"Internal Medicine-Cardiology","LABORATORY":"Visovatti Lab","LAST_NAME":"Robichaud","FIRST_NAME":"Patrick","ADDRESS":"Ann Arbor, MI","EMAIL":"probicha@umich.edu","PHONE":"734-936-7603","NUM_GROUPS":"4","TOTAL_SUBJECTS":"15"}, "SUBJECT":{"SUBJECT_TYPE":"Animal","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","SPECIES_GROUP":"Human"}, "SUBJECT_SAMPLE_FACTORS":[ { "Subject ID":"SU0011567", "Sample ID":"S00017057", "Factors":{"EXERCISE":"No","GROUP":"Healthy"}, "Additional sample data":{"name":"53-E"} }, { "Subject ID":"SU0011571", "Sample ID":"S00017061", "Factors":{"EXERCISE":"No","GROUP":"Healthy"}, "Additional sample data":{"name":"57-E"} }, { "Subject ID":"SU0011564", "Sample ID":"S00017053", "Factors":{"EXERCISE":"No","GROUP":"SSc Cath"}, "Additional sample data":{"name":"63-E"} }, { "Subject ID":"SU0011566", "Sample ID":"S00017055", "Factors":{"EXERCISE":"No","GROUP":"SSc Cath"}, "Additional sample data":{"name":"50-R"} }, { "Subject ID":"SU0011569", "Sample ID":"S00017059", "Factors":{"EXERCISE":"No","GROUP":"SSc Cath"}, "Additional sample data":{"name":"59-E"} }, { "Subject ID":"SU0011573", "Sample ID":"S00017063", "Factors":{"EXERCISE":"No","GROUP":"SSc Cath"}, "Additional sample data":{"name":"49-R"} }, { "Subject ID":"SU0011575", "Sample ID":"S00017065", "Factors":{"EXERCISE":"No","GROUP":"SSc Cath"}, "Additional sample data":{"name":"55-E"} }, { "Subject ID":"SU0011577", "Sample ID":"S00017067", "Factors":{"EXERCISE":"No","GROUP":"SSc Cath"}, "Additional sample data":{"name":"62-E"} }, { "Subject ID":"SU0011567", "Sample ID":"S00017056", "Factors":{"EXERCISE":"Yes","GROUP":"Healthy"}, "Additional sample data":{"name":"53-R"} }, { "Subject ID":"SU0011571", "Sample ID":"S00017060", "Factors":{"EXERCISE":"Yes","GROUP":"Healthy"}, "Additional sample data":{"name":"57-R"} }, { "Subject ID":"SU0011564", "Sample ID":"S00017054", "Factors":{"EXERCISE":"Yes","GROUP":"SSc Cath"}, "Additional sample data":{"name":"59-R"} }, { "Subject ID":"SU0011569", "Sample ID":"S00017058", "Factors":{"EXERCISE":"Yes","GROUP":"SSc Cath"}, "Additional sample data":{"name":"62-R"} }, { "Subject ID":"SU0011573", "Sample ID":"S00017062", "Factors":{"EXERCISE":"Yes","GROUP":"SSc Cath"}, "Additional sample data":{"name":"55-R"} }, { "Subject ID":"SU0011575", "Sample ID":"S00017064", "Factors":{"EXERCISE":"Yes","GROUP":"SSc Cath"}, "Additional sample data":{"name":"49-E"} }, { "Subject ID":"SU0011577", "Sample ID":"S00017066", "Factors":{"EXERCISE":"Yes","GROUP":"SSc Cath"}, "Additional sample data":{"name":"63-R"} } ], "COLLECTION":{"COLLECTION_SUMMARY":"-","SAMPLE_TYPE":"Plasma"}, "TREATMENT":{"TREATMENT_SUMMARY":"-"}, "SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"-","SAMPLEPREP_PROTOCOL_FILENAME":"Gly-TCA-nucleotides_analysis_protocol-2015-03-09.docx"}, "CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Waters Acquity","COLUMN_NAME":"Waters Acquity HSS T3","METHODS_ID":"AQM016","METHODS_FILENAME":"QQQ-ATP_ADP_AMP_A-update.m.zip"}, "ANALYSIS":{"ANALYSIS_TYPE":"MS","LABORATORY_NAME":"MRC2 (University of Michigan)","ACQUISITION_PARAMETERS_FILE":"QQQ-ATP_ADP_AMP_A-update.m.zip"}, "MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 6530 QTOF","INSTRUMENT_TYPE":"QTOF","MS_TYPE":"ESI","ION_MODE":"NEGATIVE"}, "MS_METABOLITE_DATA":{ "Units":"nM", "Data":[{"Metabolite":"Adenosine","S00017057":"65.4635","S00017061":"45.9903","S00017053":"42.3450","S00017055":"43.0796","S00017059":"41.2742","S00017063":"43.2446","S00017065":"53.4714","S00017067":"30.0532","S00017056":"71.2058","S00017060":"46.8618","S00017054":"56.7932","S00017058":"24.1749","S00017062":"36.8962","S00017064":"51.7170","S00017066":"16.5037"},{"Metabolite":"ADP","S00017057":"114.7699","S00017061":"238.9578","S00017053":"206.5405","S00017055":"193.0720","S00017059":"91.6454","S00017063":"271.6338","S00017065":"156.7159","S00017067":"224.2924","S00017056":"232.4423","S00017060":"187.9204","S00017054":"235.4674","S00017058":"266.2202","S00017062":"239.5008","S00017064":"146.6297","S00017066":"387.3478"},{"Metabolite":"AMP","S00017057":"47.4776","S00017061":"55.5785","S00017053":"69.7165","S00017055":"58.9721","S00017059":"42.5416","S00017063":"104.2914","S00017065":"60.2286","S00017067":"80.9138","S00017056":"85.0405","S00017060":"54.5364","S00017054":"118.4388","S00017058":"78.5573","S00017062":"78.4047","S00017064":"68.8543","S00017066":"70.4987"},{"Metabolite":"ATP","S00017057":"88.3558","S00017061":"335.9582","S00017053":"249.5417","S00017055":"179.2092","S00017059":"119.9121","S00017063":"246.0039","S00017065":"186.3683","S00017067":"265.0413","S00017056":"195.5493","S00017060":"263.4465","S00017054":"214.3195","S00017058":"253.4714","S00017062":"276.0918","S00017064":"197.0901","S00017066":"464.5435"}], "Metabolites":[{"Metabolite":"Adenosine","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"60961","inchi_key":"","kegg_id":"C00212","other_id":"Adenosine","other_id_type":"UM_Target_ID"},{"Metabolite":"ADP","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"6022","inchi_key":"","kegg_id":"C00008","other_id":"ADP","other_id_type":"UM_Target_ID"},{"Metabolite":"AMP","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"6083","inchi_key":"","kegg_id":"C00020","other_id":"AMP","other_id_type":"UM_Target_ID"},{"Metabolite":"ATP","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"5957","inchi_key":"","kegg_id":"C00002","other_id":"ATP","other_id_type":"UM_Target_ID"}] } }