{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000338","ANALYSIS_ID":"AN000549","VERSION":"1","CREATED_ON":"January 21, 2016, 7:20 am"},

"PROJECT":{"PROJECT_TITLE":"Unbiased profiling uncovers a crucial role for gut microbiome derived metabolites in modulating GI epithelial cell damage and mitigating GVHD.","PROJECT_SUMMARY":"Taxonomic alterations in the intestinal microbiota are being progressively associated with many diseases, including graft-versus host disease (GVHD). However, the impact of these alterations on microbial metabolites and by-products and their subsequent impact on disease processes, such as GVHD, are not known. Here we utilized a targetedn unbiased and blinded approach in a blinded fashion to identify novel alterations in the levels of microbial metabolites, specifically levels including the short chain fatty acid (SCFA) and endogenous histone deacetylase inhibitor (HDACi), butyrate, after allo-BMT. Surprisingly, alterations were observed only in intestinal epithelial cells (IECs) but not in the luminal contents. The reduced butyrate in IECs (CD326+) after allo-BMT resulted in decreased histone acetylation, which was restored upon local administration of exogenous butyrate. This resulted in improved IEC junctional integrity, increased anti-apoptotic proteins, decreased GVHD, and improved survival. Furthermore, alteration of endogenous microflora with 17 rationally selected strains of high butyrate producing Clostridia, also decreased GVHD and increased survival following allo-BMT in experiments performed at two different institutions. These data demonstrate an heretofore unrecognized role of microbial metabolites and suggests that local and specific alteration of microbial metabolites has direct salutary effects on GVHD target tissues and mitigates its severity.","INSTITUTE":"University of Michigan","LAST_NAME":"Mathew","FIRST_NAME":"Anna","ADDRESS":"6112 Brehm 1000 Wall Center","EMAIL":"amat@umich.edu","PHONE":"7342328228"},

"STUDY":{"STUDY_TITLE":"Unbiased profiling uncovers a crucial role for gut microbiome derived metabolites in modulating GI epithelial cell damage and mitigating GVHD.","STUDY_SUMMARY":"Taxonomic alterations in the intestinal microbiota are being progressively associated with many diseases, including graft-versus host disease (GVHD). However, the impact of these alterations on microbial metabolites and by-products and their subsequent impact on disease processes, such as GVHD, are not known. Here we utilized a targetedn unbiased and blinded approach in a blinded fashion to identify novel alterations in the levels of microbial metabolites, specifically levels including the short chain fatty acid (SCFA) and endogenous histone deacetylase inhibitor (HDACi), butyrate, after allo-BMT. Surprisingly, alterations were observed only in intestinal epithelial cells (IECs) but not in the luminal contents. The reduced butyrate in IECs (CD326+) after allo-BMT resulted in decreased histone acetylation, which was restored upon local administration of exogenous butyrate. This resulted in improved IEC junctional integrity, increased anti-apoptotic proteins, decreased GVHD, and improved survival. Furthermore, alteration of endogenous microflora with 17 rationally selected strains of high butyrate producing Clostridia, also decreased GVHD and increased survival following allo-BMT in experiments performed at two different institutions. These data demonstrate an heretofore unrecognized role of microbial metabolites and suggests that local and specific alteration of microbial metabolites has direct salutary effects on GVHD target tissues and mitigates its severity.","INSTITUTE":"University of Michigan","LAST_NAME":"Mathew","FIRST_NAME":"Anna","ADDRESS":"6112 Brehm 1000 Wall Street","EMAIL":"amat@umich.edu","PHONE":"7342328228"},

"SUBJECT":{"SUBJECT_TYPE":"Animal","SUBJECT_SPECIES":"Mus musculus"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"Naïve 1",
"Sample ID":"Naïve 1Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Naïve 2",
"Sample ID":"Naïve 2Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Naïve 3",
"Sample ID":"Naïve 3Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Naïve 4",
"Sample ID":"Naïve 4Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Naïve 5",
"Sample ID":"Naïve 5Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Syngeneic 1",
"Sample ID":"Syngeneic 1Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Syngeneic 2",
"Sample ID":"Syngeneic 2Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Syngeneic 3",
"Sample ID":"Syngeneic 3Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Syngeneic 4",
"Sample ID":"Syngeneic 4Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Syngeneic 5",
"Sample ID":"Syngeneic 5Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Allogeneic 1",
"Sample ID":"Allogeneic 1Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Allogeneic 2",
"Sample ID":"Allogeneic 2Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Allogeneic 3",
"Sample ID":"Allogeneic 3Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Allogeneic 4",
"Sample ID":"Allogeneic 4Liver",
"Factors":{"Site":"Liver"}
},
{
"Subject ID":"Naïve 1",
"Sample ID":"Naïve 1Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Naïve 2",
"Sample ID":"Naïve 2Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Naïve 3",
"Sample ID":"Naïve 3Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Naïve 4",
"Sample ID":"Naïve 4Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Naïve 5",
"Sample ID":"Naïve 5Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Syngeneic 1",
"Sample ID":"Syngeneic 1Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Syngeneic 2",
"Sample ID":"Syngeneic 2Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Syngeneic 3",
"Sample ID":"Syngeneic 3Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Syngeneic 4",
"Sample ID":"Syngeneic 4Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Syngeneic 5",
"Sample ID":"Syngeneic 5Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Allogeneic 1",
"Sample ID":"Allogeneic 1Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Allogeneic 2",
"Sample ID":"Allogeneic 2Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Allogeneic 3",
"Sample ID":"Allogeneic 3Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Allogeneic 4",
"Sample ID":"Allogeneic 4Spleen",
"Factors":{"Site":"Spleen"}
},
{
"Subject ID":"Naïve 1",
"Sample ID":"Naïve 1Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Naïve 2",
"Sample ID":"Naïve 2Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Naïve 3",
"Sample ID":"Naïve 3Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Naïve 4",
"Sample ID":"Naïve 4Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Syngeneic 1",
"Sample ID":"Syngeneic 1Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Syngeneic 2",
"Sample ID":"Syngeneic 2Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Syngeneic 3",
"Sample ID":"Syngeneic 3Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Syngeneic 4",
"Sample ID":"Syngeneic 4Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Syngeneic 5",
"Sample ID":"Syngeneic 5Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Allogeneic 1",
"Sample ID":"Allogeneic 1Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Allogeneic 2",
"Sample ID":"Allogeneic 2Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Allogeneic 3",
"Sample ID":"Allogeneic 3Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Allogeneic 4",
"Sample ID":"Allogeneic 4Serum",
"Factors":{"Site":"Serum"}
},
{
"Subject ID":"Naïve 1",
"Sample ID":"Naïve 1Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Naïve 2",
"Sample ID":"Naïve 2Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Naïve 3",
"Sample ID":"Naïve 3Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Naïve 4",
"Sample ID":"Naïve 4Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Naïve 5",
"Sample ID":"Naïve 5Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Syngeneic 1",
"Sample ID":"Syngeneic 1Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Syngeneic 2",
"Sample ID":"Syngeneic 2Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Syngeneic 3",
"Sample ID":"Syngeneic 3Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Syngeneic 4",
"Sample ID":"Syngeneic 4Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Syngeneic 5",
"Sample ID":"Syngeneic 5Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Allogeneic 1",
"Sample ID":"Allogeneic 1Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Allogeneic 2",
"Sample ID":"Allogeneic 2Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Allogeneic 3",
"Sample ID":"Allogeneic 3Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Allogeneic 4",
"Sample ID":"Allogeneic 4Intestine",
"Factors":{"Site":"Intestine"}
},
{
"Subject ID":"Naïve 1",
"Sample ID":"Naïve 1Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Naïve 2",
"Sample ID":"Naïve 2Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Naïve 3",
"Sample ID":"Naïve 3Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Naïve 4",
"Sample ID":"Naïve 4Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Syngeneic 1",
"Sample ID":"Syngeneic 1Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Syngeneic 2",
"Sample ID":"Syngeneic 2Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Syngeneic 3",
"Sample ID":"Syngeneic 3Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Syngeneic 4",
"Sample ID":"Syngeneic 4Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Syngeneic 5",
"Sample ID":"Syngeneic 5Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Allogeneic 1",
"Sample ID":"Allogeneic 1Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Allogeneic 2",
"Sample ID":"Allogeneic 2Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Allogeneic 3",
"Sample ID":"Allogeneic 3Stool",
"Factors":{"Site":"Stool"}
},
{
"Subject ID":"Allogeneic 4",
"Sample ID":"Allogeneic 4Stool",
"Factors":{"Site":"Stool"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Female C57BL/6 (I-Ab; CD45.2+), BALB/c (H2d), and C3H.sw (H2b) mice were purchased from National Cancer Institute. The age of mice used for experiments ranged between 7 and 12 weeks."},

"TREATMENT":{"TREATMENT_SUMMARY":"BMTs were performed as previously described {Reddy:2005dc}{Reddy:2008kl}. Briefly, syngeneic (BALB/c ? BALC/b or C57BL/6 ? C57BL/6) and allogeneic (C57BL/6 ? BALB/c or C3H.sw ? C57BL/6) recipients received lethal irradiation. On day -1, BALB/c recipients received a total of 800 cGy of irradiation (split dose separated by 3 hours) and B6 animals received a single dose of 1000 cGy. Donor splenic CD90.2+ T cells were magnetically separated using an autoMACs (Miltenyi Biotec; Bergisch Gladbach, Germany) and 0.5 x 106 – 1 x 106 T cells were transferred to BALB/c recipients and 2 x 106 T cells were transferred to C57BL/6 recipients. 5 x 106 donor whole bone marrow was transferred to all recipients."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"To determine targeted fatty acid quantitation, samples (plasma, spleen, liver, intestine, and intestinal fecal content) from mice 7d and 21d post-transplant were harvested, homogenized, and snap-frozen in liquid N2. Homogenized tissues were normalized to their protein content, while 50µL of plasma was used per sample and Equal volumes of plasma and homogenized tissue were utilized, while50 mg fecal content was weighed at necropsy before extraction. Samples were dispersed in acidified water spiked with stable isotope-labeled SCFA standards and extracted with diethyl ether."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Agilent 6890N","COLUMN_NAME":"Phenomenex ZB-WAX"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 5973","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"EI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"mmol/mg",

"Data":[{"Metabolite":"Acetate","Naïve 1Liver":"0.001367051","Naïve 2Liver":"0.007716075","Naïve 3Liver":"0.00069004","Naïve 4Liver":"0.022916188","Naïve 5Liver":"0.00133827","Syngeneic 1Liver":"0.005741469","Syngeneic 2Liver":"0","Syngeneic 3Liver":"0","Syngeneic 4Liver":"0","Syngeneic 5Liver":"0","Allogeneic 1Liver":"0","Allogeneic 2Liver":"0","Allogeneic 3Liver":"0.014757123","Allogeneic 4Liver":"0","Naïve 1Spleen":"0","Naïve 2Spleen":"0","Naïve 3Spleen":"0","Naïve 4Spleen":"0","Naïve 5Spleen":"0","Syngeneic 1Spleen":"0","Syngeneic 2Spleen":"0","Syngeneic 3Spleen":"0","Syngeneic 4Spleen":"0","Syngeneic 5Spleen":"0","Allogeneic 1Spleen":"0","Allogeneic 2Spleen":"0","Allogeneic 3Spleen":"0.081072436","Allogeneic 4Spleen":"0","Naïve 1Serum":"5.647847997","Naïve 2Serum":"8.214424336","Naïve 3Serum":"9.624010428","Naïve 4Serum":"9.28155694","Syngeneic 1Serum":"22.89463266","Syngeneic 2Serum":"11.59203424","Syngeneic 3Serum":"11.06359575","Syngeneic 4Serum":"7.292094314","Syngeneic 5Serum":"6.285193841","Allogeneic 1Serum":"15.41191581","Allogeneic 2Serum":"8.2887712","Allogeneic 3Serum":"9.69968101","Allogeneic 4Serum":"3.473977961","Naïve 1Intestine":"2.767585801","Naïve 2Intestine":"2.66078925","Naïve 3Intestine":"2.046065923","Naïve 4Intestine":"2.448508002","Naïve 5Intestine":"1.271333349","Syngeneic 1Intestine":"7.727652087","Syngeneic 2Intestine":"3.610026349","Syngeneic 3Intestine":"2.201334274","Syngeneic 4Intestine":"3.277224787","Syngeneic 5Intestine":"2.69672131","Allogeneic 1Intestine":"1.687665139","Allogeneic 2Intestine":"1.931337906","Allogeneic 3Intestine":"1.257216979","Allogeneic 4Intestine":"1.837031732","Naïve 1Stool":"0.749530159","Naïve 2Stool":"0.683581689","Naïve 3Stool":"0.206257104","Naïve 4Stool":"0.712036465","Syngeneic 1Stool":"0.476160492","Syngeneic 2Stool":"0.648220862","Syngeneic 3Stool":"1.155829949","Syngeneic 4Stool":"1.152820087","Syngeneic 5Stool":"1.887668206","Allogeneic 1Stool":"0.937428513","Allogeneic 2Stool":"0.700576912","Allogeneic 3Stool":"0.037898052","Allogeneic 4Stool":"0.014786293"},{"Metabolite":"Propionate","Naïve 1Liver":"0.000121787","Naïve 2Liver":"0.000788373","Naïve 3Liver":"0.000123634","Naïve 4Liver":"0.002348076","Naïve 5Liver":"0.00011816","Syngeneic 1Liver":"0.000513143","Syngeneic 2Liver":"5.69155E-05","Syngeneic 3Liver":"9.0708E-05","Syngeneic 4Liver":"0.000885764","Syngeneic 5Liver":"0.000160456","Allogeneic 1Liver":"0.000116431","Allogeneic 2Liver":"9.77302E-05","Allogeneic 3Liver":"0.000430537","Allogeneic 4Liver":"0.000107768","Naïve 1Spleen":"0.033406896","Naïve 2Spleen":"0.025089803","Naïve 3Spleen":"0.017042438","Naïve 4Spleen":"0.012267999","Naïve 5Spleen":"0.127633464","Syngeneic 1Spleen":"0.033465559","Syngeneic 2Spleen":"0.017593407","Syngeneic 3Spleen":"0.014915732","Syngeneic 4Spleen":"0.030600009","Syngeneic 5Spleen":"0.017196979","Allogeneic 1Spleen":"0.016470551","Allogeneic 2Spleen":"0.013616558","Allogeneic 3Spleen":"0.096270169","Allogeneic 4Spleen":"0.016989246","Naïve 1Serum":"0.00598744","Naïve 2Serum":"0.012801624","Naïve 3Serum":"0.010924764","Naïve 4Serum":"0.00765825","Syngeneic 1Serum":"0.112370415","Syngeneic 2Serum":"0.014437689","Syngeneic 3Serum":"0.010796871","Syngeneic 4Serum":"0.007105926","Syngeneic 5Serum":"0.004877959","Allogeneic 1Serum":"0.013378065","Allogeneic 2Serum":"0.008389855","Allogeneic 3Serum":"0.006662872","Allogeneic 4Serum":"0.00750329","Naïve 1Intestine":"0.00328551","Naïve 2Intestine":"0.002111409","Naïve 3Intestine":"0.002630898","Naïve 4Intestine":"0.001931527","Naïve 5Intestine":"0.001381519","Syngeneic 1Intestine":"0.011840476","Syngeneic 2Intestine":"0.002226106","Syngeneic 3Intestine":"0.001731028","Syngeneic 4Intestine":"0.002636137","Syngeneic 5Intestine":"0.002722042","Allogeneic 1Intestine":"0.001341843","Allogeneic 2Intestine":"0.001495415","Allogeneic 3Intestine":"0.000990372","Allogeneic 4Intestine":"0.001465277","Naïve 1Stool":"0.012106018","Naïve 2Stool":"0.006638055","Naïve 3Stool":"0.005022226","Naïve 4Stool":"0.018690957","Syngeneic 1Stool":"0.010208971","Syngeneic 2Stool":"0.009662842","Syngeneic 3Stool":"0.008168425","Syngeneic 4Stool":"0.007912509","Syngeneic 5Stool":"0.074586992","Allogeneic 1Stool":"0.009566022","Allogeneic 2Stool":"0.043764996","Allogeneic 3Stool":"0.008898235","Allogeneic 4Stool":"0.007423887"},{"Metabolite":"Butyrate","Naïve 1Liver":"0.00026163","Naïve 2Liver":"0.000225814","Naïve 3Liver":"0.000190029","Naïve 4Liver":"0.000731128","Naïve 5Liver":"0.000223815","Syngeneic 1Liver":"0.000217958","Syngeneic 2Liver":"0.000153236","Syngeneic 3Liver":"0.000162271","Syngeneic 4Liver":"0.001501314","Syngeneic 5Liver":"0.000392283","Allogeneic 1Liver":"0.000235478","Allogeneic 2Liver":"0.000171282","Allogeneic 3Liver":"0.000581431","Allogeneic 4Liver":"0.000277101","Naïve 1Spleen":"0.049958543","Naïve 2Spleen":"0.042824674","Naïve 3Spleen":"0.042448567","Naïve 4Spleen":"0.035067591","Naïve 5Spleen":"0.103425177","Syngeneic 1Spleen":"0.049481881","Syngeneic 2Spleen":"0.031490695","Syngeneic 3Spleen":"0.034001154","Syngeneic 4Spleen":"0.037204836","Syngeneic 5Spleen":"0.030599724","Allogeneic 1Spleen":"0.028694651","Allogeneic 2Spleen":"0.030859098","Allogeneic 3Spleen":"0.074958094","Allogeneic 4Spleen":"0.034568972","Naïve 1Serum":"0.003031295","Naïve 2Serum":"0.006752618","Naïve 3Serum":"0.008740629","Naïve 4Serum":"0.006863989","Syngeneic 1Serum":"0.005127956","Syngeneic 2Serum":"0.009055118","Syngeneic 3Serum":"0.011226867","Syngeneic 4Serum":"0.009285616","Syngeneic 5Serum":"0.009109051","Allogeneic 1Serum":"0.025908296","Allogeneic 2Serum":"0.009466443","Allogeneic 3Serum":"0.013331982","Allogeneic 4Serum":"0.005083552","Naïve 1Intestine":"0.006437724","Naïve 2Intestine":"0.006573793","Naïve 3Intestine":"0.011080684","Naïve 4Intestine":"0.006390763","Naïve 5Intestine":"0.006078836","Syngeneic 1Intestine":"0.006725058","Syngeneic 2Intestine":"0.005659014","Syngeneic 3Intestine":"0.00753625","Syngeneic 4Intestine":"0.005908748","Syngeneic 5Intestine":"0.009017474","Allogeneic 1Intestine":"0.004179697","Allogeneic 2Intestine":"0.00407625","Allogeneic 3Intestine":"0.003737486","Allogeneic 4Intestine":"0.005208571","Naïve 1Stool":"0.027384075","Naïve 2Stool":"0.021769427","Naïve 3Stool":"0.022385766","Naïve 4Stool":"0.023781949","Syngeneic 1Stool":"0.029541372","Syngeneic 2Stool":"0.030275599","Syngeneic 3Stool":"0.018330486","Syngeneic 4Stool":"0.016473446","Syngeneic 5Stool":"0.031210856","Allogeneic 1Stool":"0.02707988","Allogeneic 2Stool":"0.003663462","Allogeneic 3Stool":"0.021958061","Allogeneic 4Stool":"0.024878056"},{"Metabolite":"Isovalerate","Naïve 1Liver":"8.10428E-06","Naïve 2Liver":"0.000156858","Naïve 3Liver":"9.37518E-06","Naïve 4Liver":"0.000218691","Naïve 5Liver":"5.65992E-06","Syngeneic 1Liver":"2.791E-05","Syngeneic 2Liver":"2.58036E-06","Syngeneic 3Liver":"3.61924E-06","Syngeneic 4Liver":"0.000365433","Syngeneic 5Liver":"6.80905E-06","Allogeneic 1Liver":"5.42456E-06","Allogeneic 2Liver":"3.38428E-06","Allogeneic 3Liver":"1.46904E-05","Allogeneic 4Liver":"1.54484E-05","Naïve 1Spleen":"0.004161985","Naïve 2Spleen":"0.004429088","Naïve 3Spleen":"0.001628617","Naïve 4Spleen":"0.001492322","Naïve 5Spleen":"0.060917016","Syngeneic 1Spleen":"0.008999963","Syngeneic 2Spleen":"0.001578636","Syngeneic 3Spleen":"0.002206519","Syngeneic 4Spleen":"0.006145897","Syngeneic 5Spleen":"0.001829125","Allogeneic 1Spleen":"0.001401678","Allogeneic 2Spleen":"0.001124321","Allogeneic 3Spleen":"0.027286603","Allogeneic 4Spleen":"0.00157589","Naïve 1Serum":"0.000588401","Naïve 2Serum":"0.000589966","Naïve 3Serum":"0.000556775","Naïve 4Serum":"0.000555848","Syngeneic 1Serum":"0.006137887","Syngeneic 2Serum":"0.001568368","Syngeneic 3Serum":"0.000609828","Syngeneic 4Serum":"0.000555481","Syngeneic 5Serum":"0.000651862","Allogeneic 1Serum":"0.001120289","Allogeneic 2Serum":"0.000668757","Allogeneic 3Serum":"0.000620523","Allogeneic 4Serum":"0.000650764","Naïve 1Intestine":"0.000361389","Naïve 2Intestine":"0.00024681","Naïve 3Intestine":"0.000331888","Naïve 4Intestine":"0.000187795","Naïve 5Intestine":"0.000122336","Syngeneic 1Intestine":"0.002853527","Syngeneic 2Intestine":"0.000222697","Syngeneic 3Intestine":"0.000202093","Syngeneic 4Intestine":"0.000229123","Syngeneic 5Intestine":"0.000205201","Allogeneic 1Intestine":"7.94643E-05","Allogeneic 2Intestine":"0.000110142","Allogeneic 3Intestine":"9.09155E-05","Allogeneic 4Intestine":"0.00010178","Naïve 1Stool":"0.000600086","Naïve 2Stool":"0.000414233","Naïve 3Stool":"0.000284353","Naïve 4Stool":"0.001687938","Syngeneic 1Stool":"0.00061822","Syngeneic 2Stool":"0.000596523","Syngeneic 3Stool":"0.000699725","Syngeneic 4Stool":"0.000627953","Syngeneic 5Stool":"0.00503049","Allogeneic 1Stool":"0.001387744","Allogeneic 2Stool":"0.011859734","Allogeneic 3Stool":"0.001901947","Allogeneic 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"Metabolites":[{"metabolite_name":"Acetate"},{"metabolite_name":"Propionate"},{"metabolite_name":"Butyrate"},{"metabolite_name":"Isovalerate"},{"metabolite_name":"Valerate"},{"metabolite_name":"Hexanoate"},{"metabolite_name":"Heptanoate"},{"metabolite_name":"Octanoic acid"},{"metabolite_name":"Nonanoic acid"},{"metabolite_name":"Decanoic acid"},{"metabolite_name":"Undecanoic acid"},{"metabolite_name":"Dodecanoic acid"},{"metabolite_name":"Tridecanoic acid"},{"metabolite_name":"Tetradecanoic acid"},{"metabolite_name":"Pentadecanoic acid"},{"metabolite_name":"Hexadecanoic acid"},{"metabolite_name":"Heptadecanoic acid"},{"metabolite_name":"Octadecanoic acid"}]
}

}