{
"METABOLOMICS WORKBENCH":{"VERSION":"1","CREATED_ON":"November 17, 2016, 3:36 pm"},

"PROJECT":{"PROJECT_TITLE":"Metabolomics Analysis of Triple Negative Breast Cancer Cell Lines","PROJECT_TYPE":"Metabolomics Analysis","PROJECT_SUMMARY":"To date there are no clinically approved targeted therapies for triple negative breast cancer (TNBC). In addition to the absence of estrogen, progesterone, and HER2/neu receptors, TNBCs possess characteristics that make them some of the most aggressive forms of breast cancer (BCa). In terms of epidemiology, breast cancers with the triple negative profile present at a higher prevalence in premenopausal women under the age of 40, usually with a BMI greater than 30, and have higher incidences of mutations in BRCA1 or BRCA2 genes. Additionally, several studies have shown a higher prevalence in African American women, demonstrating a health disparity. In spite of this knowledge and the fact that most people respond to initial chemotherapeutic treatment, lasting treatment modalities used for the cure and maintenance of other BCa subtypes generally fail to significantly increase disease-free survival or diminish the rates of recurrence within the first five years after initial detection of TNBC. Our ultimate goal is to identify novel biomarkers which may be leveraged for initiating prevention strategies in high risk populations, earlier detection, or targeted treatment of this disease.","INSTITUTE":"RTI International","DEPARTMENT":"Discovery Sciences","LABORATORY":"STS/NIH Eastern Regional Comprehensive Metabolomics Resource Core (RTI RCMRC)","LAST_NAME":"Delisha","FIRST_NAME":"Stewart","ADDRESS":"3040, East Cornwallis Road, Research Triangle Park, NC 27709","EMAIL":"dstewart@rti.org","PHONE":"919-541-7204","FUNDING_SOURCE":"Internal IR&D (RTI International) and RCMRC","PUBLICATIONS":"J. Proteome Res., Article ASAP","DOI":"DOI: 10.1021/acs.jproteome.6b00430"},

"STUDY":{"STUDY_TITLE":"Metabolomics Analysis of Triple Negative Breast Cancer (BCa) Cell Lines","STUDY_TYPE":"Metabolomics comparison of different breast cancer cell lines","STUDY_SUMMARY":"We used untargeted metabolomic profiling to distinguish this form of BCa from estrogen receptor positive (ER+) subtypes (+/- HER2/neu) and determine that may explain why a commonly used chemotherapeutic, paclitaxel, is generally ineffective at eliciting long-term cytotoxic and/or cytostatic responses in cell line models of TNBC. This metabolomics study used broad spectrum 1H NMR to compare Luminal A (BT474, MCF-7) and triple-negative (MDA-MB-231, MDA-MB-468) BCa cell lines, to determine differences in the two subtypes as well as distinguish therapeutic treatment responses for identifying new targets for drug discovery.","INSTITUTE":"RTI International","DEPARTMENT":"Discovery Sciences","LABORATORY":"STS/RCMRC","LAST_NAME":"Sumner","FIRST_NAME":"Susan","ADDRESS":"3040, East Cornwallis Road, Research Triangle Park, NC 27709","EMAIL":"ssumner@rti.org","PHONE":"919-541-7479","NUM_GROUPS":"4","TOTAL_SUBJECTS":"24","NUM_MALES":"N/A","NUM_FEMALES":"N/A","STUDY_COMMENTS":"4 breast cancer cell lines, treated with paclitaxel compared to controls (3 replicates/line/condition)","PUBLICATIONS":"J. Proteome Res., Article ASAP, DOI: 10.1021/acs.jproteome.6b00430"},

"SUBJECT":{"SUBJECT_TYPE":"Cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","CELL_BIOSOURCE_OR_SUPPLIER":"American Type Culture Collection","CELL_STRAIN_DETAILS":"Breast Cancer Cell lines (BT474, MCF-7, MDA-MB-231, MDA-MB-468)","CELL_PRIMARY_IMMORTALIZED":"Immortalized"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"LB474CDM48R1N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"LB474CDM48R2N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"LB474CDM48R3N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"LB474TDM48R1N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"LB474TDM48R2N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"LB474TDM48R3N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"LBMCFCDM48R1N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"LBMCFCDM48R2N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"LBMCFCDM48R3N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"LBMCFTDM48R1N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"LBMCFTDM48R2N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"LBMCFTDM48R3N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"TB231CDM48R1N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"TB231CDM48R2N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"TB231CDM48R3N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"TB231TDM48R1N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"TB231TDM48R2N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"TB231TDM48R3N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"TB468CDM48R1N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"TB468CDM48R2N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"TB468CDM48R3N",
"Factors":{"Treatment":"Media alone"}
},
{
"Subject ID":"-",
"Sample ID":"TB468TDM48R1N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"TB468TDM48R2N",
"Factors":{"Treatment":"Taxol"}
},
{
"Subject ID":"-",
"Sample ID":"TB468TDM48R3N",
"Factors":{"Treatment":"Taxol"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Cell samples were scraped off the dish in 4 mL of 50:50 acetonitrile:water and collected into 15 mL tubes prior to homogenization and extraction.","SAMPLE_TYPE":"cells","STORAGE_CONDITIONS":"-80°C"},

"TREATMENT":{"TREATMENT_SUMMARY":"Briefly, mycoplasma tested and certified BCa cell lines will be purchased from American Type Culture Collection (ATCC) and maintained under the manufacturer’s recommended conditions. Cells were grown for 48 h in the presence or absence of chemotherapeutic agent paclitaxel (10 nM)."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Added 1 mL of an ice-cold chloroform to the tubes and 10 ceramic beads. Tubes were vortexed for 30 seconds on a multi-tube vortexer at 5000 rpm three times to homogenize and centrifuged samples at 4 °C in a swinging bucket centrifuge for 60 min at 3,700 rpm. Majority of aqueous (top) layer was carefully transferred to 5 mL cryotubes. Majority of lipid (bottom) layer was carefully transferred to 7 mL glass vials. Remaining protein layer and residual aqueous & lipid layers were transferred into a 2 mL Lo-Bind tubes. Original tubes were rinsed with 600 µL of 2:1 chloroform:methanol solution and transferred to the 2 mL tubes. Centrifuged tubes at 15,000 rpm at 4 °C for 20 min and transferred remaining aqueous & lipid fractions into respective tubes. For each study sample, an 800 µL aliquot of the aqueous fractions was transferred to labeled 2.0 mL Lo-Bind tubes. Analytical pooled QC samples were generated by transferring an additional 75 µL aliquot from all study samples into a 10 mL tube. The total pooled sample was vortexed and 800 µL aliquots were transferred to 2.0 mL tubes labeled Pool. All tubes were frozen for 1 hr and lyophilized to dryness overnight. Samples were reconstituted by adding 700 µL of 90:10 D2O:Chenomx ISTD master mix to each, vortexed for 2 mins and centrifuged at 16,000 rcf for 4 min. A 600 µL aliquot of the supernatant was transferred into 5 mm NMR tubes (Bruker-Biospin, Switzerland), and kept on ice until data acquisition.","PROCESSING_METHOD":"lyophilization","EXTRACTION_METHOD":"Acetonitrile:water and chloroform","SAMPLE_RESUSPENSION":"NMR master mix","CELL_TYPE":"breast cancer"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"-","INSTRUMENT_NAME":"-","COLUMN_NAME":"-"},

"ANALYSIS":{"ANALYSIS_TYPE":"NMR","LABORATORY_NAME":"David H. Murdock Research Institute.","OPERATOR_NAME":"Jason Winnike","DETECTOR_TYPE":"NMR","SOFTWARE_VERSION":"TopSpin 3.2","ACQUISITION_DATE":"7/29/14 and 8/13/14"},

"NM":{"INSTRUMENT_NAME":"Bruker Avance III 600 MHz","INSTRUMENT_TYPE":"FT-NMR","NMR_EXPERIMENT_TYPE":"1D-1H","FIELD_FREQUENCY_LOCK":"Deuterium","STANDARD_CONCENTRATION":"0.5 mM DSS","SPECTROMETER_FREQUENCY":"600 MHz","NMR_PROBE":"5 mm ATMA Cryoprobe","NMR_SOLVENT":"D2O","NMR_TUBE_SIZE":"5 mm","SHIMMING_METHOD":"Topshim","PULSE_SEQUENCE":"noesyprid","WATER_SUPPRESSION":"yes","PULSE_WIDTH":"9.28 us","POWER_LEVEL":"39.811 W","RECEIVER_GAIN":"50.8","OFFSET_FREQUENCY":"2817.50 Hz","PRESATURATION_POWER_LEVEL":"0.000025119 W","CHEMICAL_SHIFT_REF_CPD":"DSS","TEMPERATURE":"298.1 K","NUMBER_OF_SCANS":"256","DUMMY_SCANS":"4","ACQUISITION_TIME":"2.482 s","RELAXATION_DELAY":"2 s","SPECTRAL_WIDTH":"11.0011 ppm, 6602.113 Hz","NUM_DATA_POINTS_ACQUIRED":"32768","REAL_DATA_POINTS":"16384","LINE_BROADENING":"0.5 Hz","ZERO_FILLING":"yes","APODIZATION":"Lorentzian","BASELINE_CORRECTION_METHOD":"Polynomial","CHEMICAL_SHIFT_REF_STD":"DSS","BINNED_INCREMENT":"0.04","BINNED_DATA_EXCLUDED_RANGE":"water (4.66 - 4.86 ppm); imidazole (7.15-7.26 ppm)"},

"Data":[{"Bin range(ppm)":"[0.14 .. 0.18]","LB474CDM48R1N":"0.7240","LB474CDM48R2N":"0.4920","LB474CDM48R3N":"0.6100","LB474TDM48R1N":"0.5930","LB474TDM48R2N":"0.7300","LB474TDM48R3N":"0.7430","LBMCFCDM48R1N":"0.6730","LBMCFCDM48R2N":"0.7000","LBMCFCDM48R3N":"0.6910","LBMCFTDM48R1N":"0.6140","LBMCFTDM48R2N":"0.7590","LBMCFTDM48R3N":"0.6200","TB231CDM48R1N":"0.7060","TB231CDM48R2N":"0.6880","TB231CDM48R3N":"0.6590","TB231TDM48R1N":"0.5570","TB231TDM48R2N":"0.5810","TB231TDM48R3N":"0.6870","TB468CDM48R1N":"0.7540","TB468CDM48R2N":"0.8360","TB468CDM48R3N":"0.7170","TB468TDM48R1N":"0.7720","TB468TDM48R2N":"0.5910","TB468TDM48R3N":"0.7970"},{"Bin range(ppm)":"[0.18 .. 0.20]","LB474CDM48R1N":"0.4100","LB474CDM48R2N":"0.2830","LB474CDM48R3N":"0.2890","LB474TDM48R1N":"0.2730","LB474TDM48R2N":"0.4650","LB474TDM48R3N":"0.3000","LBMCFCDM48R1N":"0.3920","LBMCFCDM48R2N":"0.3910","LBMCFCDM48R3N":"0.4110","LBMCFTDM48R1N":"0.3360","LBMCFTDM48R2N":"0.4450","LBMCFTDM48R3N":"0.3490","TB231CDM48R1N":"0.4310","TB231CDM48R2N":"0.4180","TB231CDM48R3N":"0.3940","TB231TDM48R1N":"0.3410","TB231TDM48R2N":"0.3500","TB231TDM48R3N":"0.4210","TB468CDM48R1N":"0.4800","TB468CDM48R2N":"0.5440","TB468CDM48R3N":"0.4290","TB468TDM48R1N":"0.4720","TB468TDM48R2N":"0.3660","TB468TDM48R3N":"0.4920"},{"Bin range(ppm)":"[0.20 .. 0.22]","LB474CDM48R1N":"0.3040","LB474CDM48R2N":"0.2360","LB474CDM48R3N":"0.2210","LB474TDM48R1N":"0.2620","LB474TDM48R2N":"0.3720","LB474TDM48R3N":"0.1790","LBMCFCDM48R1N":"0.3300","LBMCFCDM48R2N":"0.3300","LBMCFCDM48R3N":"0.3390","LBMCFTDM48R1N":"0.2830","LBMCFTDM48R2N":"0.3610","LBMCFTDM48R3N":"0.2820","TB231CDM48R1N":"0.3590","TB231CDM48R2N":"0.3380","TB231CDM48R3N":"0.3280","TB231TDM48R1N":"0.2780","TB231TDM48R2N":"0.2840","TB231TDM48R3N":"0.3500","TB468CDM48R1N":"0.3920","TB468CDM48R2N":"0.4410","TB468CDM48R3N":"0.3550","TB468TDM48R1N":"0.3770","TB468TDM48R2N":"0.3070","TB468TDM48R3N":"0.4010"},{"Bin range(ppm)":"[0.22 .. 0.25]","LB474CDM48R1N":"0.3540","LB474CDM48R2N":"0.2770","LB474CDM48R3N":"0.2770","LB474TDM48R1N":"0.2760","LB474TDM48R2N":"0.4220","LB474TDM48R3N":"0.2220","LBMCFCDM48R1N":"0.3930","LBMCFCDM48R2N":"0.3780","LBMCFCDM48R3N":"0.4020","LBMCFTDM48R1N":"0.3400","LBMCFTDM48R2N":"0.4230","LBMCFTDM48R3N":"0.3210","TB231CDM48R1N":"0.3950","TB231CDM48R2N":"0.3880","TB231CDM48R3N":"0.3680","TB231TDM48R1N":"0.3030","TB231TDM48R2N":"0.3240","TB231TDM48R3N":"0.3950","TB468CDM48R1N":"0.4590","TB468CDM48R2N":"0.5230","TB468CDM48R3N":"0.4030","TB468TDM48R1N":"0.4420","TB468TDM48R2N":"0.3490","TB468TDM48R3N":"0.4620"},{"Bin range(ppm)":"[0.25 .. 0.27]","LB474CDM48R1N":"0.3920","LB474CDM48R2N":"0.2740","LB474CDM48R3N":"0.3050","LB474TDM48R1N":"0.2940","LB474TDM48R2N":"0.4340","LB474TDM48R3N":"0.2190","LBMCFCDM48R1N":"0.4260","LBMCFCDM48R2N":"0.4260","LBMCFCDM48R3N":"0.4390","LBMCFTDM48R1N":"0.3860","LBMCFTDM48R2N":"0.4820","LBMCFTDM48R3N":"0.3700","TB231CDM48R1N":"0.4170","TB231CDM48R2N":"0.3990","TB231CDM48R3N":"0.3750","TB231TDM48R1N":"0.3140","TB231TDM48R2N":"0.3440","TB231TDM48R3N":"0.4210","TB468CDM48R1N":"0.4880","TB468CDM48R2N":"0.5430","TB468CDM48R3N":"0.4350","TB468TDM48R1N":"0.4600","TB468TDM48R2N":"0.3850","TB468TDM48R3N":"0.4880"},{"Bin range(ppm)":"[0.27 .. 0.29]","LB474CDM48R1N":"0.3830","LB474CDM48R2N":"0.2910","LB474CDM48R3N":"0.2990","LB474TDM48R1N":"0.3200","LB474TDM48R2N":"0.4490","LB474TDM48R3N":"0.2370","LBMCFCDM48R1N":"0.4660","LBMCFCDM48R2N":"0.4600","LBMCFCDM48R3N":"0.4980","LBMCFTDM48R1N":"0.4240","LBMCFTDM48R2N":"0.5170","LBMCFTDM48R3N":"0.4020","TB231CDM48R1N":"0.4300","TB231CDM48R2N":"0.4070","TB231CDM48R3N":"0.4010","TB231TDM48R1N":"0.3410","TB231TDM48R2N":"0.3340","TB231TDM48R3N":"0.4370","TB468CDM48R1N":"0.5070","TB468CDM48R2N":"0.5470","TB468CDM48R3N":"0.4710","TB468TDM48R1N":"0.4870","TB468TDM48R2N":"0.3980","TB468TDM48R3N":"0.4880"},{"Bin range(ppm)":"[0.29 .. 0.31]","LB474CDM48R1N":"0.5590","LB474CDM48R2N":"0.4260","LB474CDM48R3N":"0.4590","LB474TDM48R1N":"0.4500","LB474TDM48R2N":"0.6680","LB474TDM48R3N":"0.3730","LBMCFCDM48R1N":"0.6400","LBMCFCDM48R2N":"0.6180","LBMCFCDM48R3N":"0.6750","LBMCFTDM48R1N":"0.6120","LBMCFTDM48R2N":"0.6880","LBMCFTDM48R3N":"0.5820","TB231CDM48R1N":"0.6340","TB231CDM48R2N":"0.5990","TB231CDM48R3N":"0.5950","TB231TDM48R1N":"0.4920","TB231TDM48R2N":"0.5160","TB231TDM48R3N":"0.6230","TB468CDM48R1N":"0.7140","TB468CDM48R2N":"0.7860","TB468CDM48R3N":"0.6660","TB468TDM48R1N":"0.6820","TB468TDM48R2N":"0.5820","TB468TDM48R3N":"0.7130"},{"Bin range(ppm)":"[0.31 .. 0.33]","LB474CDM48R1N":"0.4200","LB474CDM48R2N":"0.3180","LB474CDM48R3N":"0.3600","LB474TDM48R1N":"0.3550","LB474TDM48R2N":"0.4990","LB474TDM48R3N":"0.2890","LBMCFCDM48R1N":"0.4700","LBMCFCDM48R2N":"0.4670","LBMCFCDM48R3N":"0.5140","LBMCFTDM48R1N":"0.4500","LBMCFTDM48R2N":"0.5140","LBMCFTDM48R3N":"0.4310","TB231CDM48R1N":"0.4650","TB231CDM48R2N":"0.4480","TB231CDM48R3N":"0.4360","TB231TDM48R1N":"0.3820","TB231TDM48R2N":"0.3790","TB231TDM48R3N":"0.4790","TB468CDM48R1N":"0.5650","TB468CDM48R2N":"0.6090","TB468CDM48R3N":"0.5150","TB468TDM48R1N":"0.5210","TB468TDM48R2N":"0.4450","TB468TDM48R3N":"0.5480"},{"Bin range(ppm)":"[0.33 .. 0.35]","LB474CDM48R1N":"0.4530","LB474CDM48R2N":"0.3390","LB474CDM48R3N":"0.3600","LB474TDM48R1N":"0.3850","LB474TDM48R2N":"0.5400","LB474TDM48R3N":"0.3020","LBMCFCDM48R1N":"0.5430","LBMCFCDM48R2N":"0.5440","LBMCFCDM48R3N":"0.5750","LBMCFTDM48R1N":"0.5080","LBMCFTDM48R2N":"0.6070","LBMCFTDM48R3N":"0.4850","TB231CDM48R1N":"0.4970","TB231CDM48R2N":"0.4670","TB231CDM48R3N":"0.4560","TB231TDM48R1N":"0.3870","TB231TDM48R2N":"0.3960","TB231TDM48R3N":"0.5060","TB468CDM48R1N":"0.6170","TB468CDM48R2N":"0.6630","TB468CDM48R3N":"0.5730","TB468TDM48R1N":"0.5820","TB468TDM48R2N":"0.4970","TB468TDM48R3N":"0.6000"},{"Bin range(ppm)":"[0.35 .. 0.41]","LB474CDM48R1N":"1.3900","LB474CDM48R2N":"1.0400","LB474CDM48R3N":"1.2500","LB474TDM48R1N":"1.1700","LB474TDM48R2N":"1.7100","LB474TDM48R3N":"0.9960","LBMCFCDM48R1N":"1.9400","LBMCFCDM48R2N":"1.8300","LBMCFCDM48R3N":"2.0400","LBMCFTDM48R1N":"1.8600","LBMCFTDM48R2N":"2.0700","LBMCFTDM48R3N":"1.7100","TB231CDM48R1N":"1.5500","TB231CDM48R2N":"1.4600","TB231CDM48R3N":"1.4300","TB231TDM48R1N":"1.2500","TB231TDM48R2N":"1.2500","TB231TDM48R3N":"1.5600","TB468CDM48R1N":"2.0200","TB468CDM48R2N":"2.1300","TB468CDM48R3N":"1.8500","TB468TDM48R1N":"1.8300","TB468TDM48R2N":"1.6100","TB468TDM48R3N":"1.9200"},{"Bin range(ppm)":"[0.41 .. 0.43]","LB474CDM48R1N":"0.5240","LB474CDM48R2N":"0.3740","LB474CDM48R3N":"0.4550","LB474TDM48R1N":"0.4430","LB474TDM48R2N":"0.6220","LB474TDM48R3N":"0.3590","LBMCFCDM48R1N":"0.6250","LBMCFCDM48R2N":"0.6230","LBMCFCDM48R3N":"0.6790","LBMCFTDM48R1N":"0.5970","LBMCFTDM48R2N":"0.7160","LBMCFTDM48R3N":"0.5580","TB231CDM48R1N":"0.5690","TB231CDM48R2N":"0.5350","TB231CDM48R3N":"0.5230","TB231TDM48R1N":"0.4630","TB231TDM48R2N":"0.4590","TB231TDM48R3N":"0.5760","TB468CDM48R1N":"0.7040","TB468CDM48R2N":"0.7550","TB468CDM48R3N":"0.6650","TB468TDM48R1N":"0.6510","TB468TDM48R2N":"0.5680","TB468TDM48R3N":"0.6860"},{"Bin range(ppm)":"[0.43 .. 0.45]","LB474CDM48R1N":"0.5590","LB474CDM48R2N":"0.4030","LB474CDM48R3N":"0.4950","LB474TDM48R1N":"0.4620","LB474TDM48R2N":"0.6600","LB474TDM48R3N":"0.4100","LBMCFCDM48R1N":"0.6720","LBMCFCDM48R2N":"0.6540","LBMCFCDM48R3N":"0.6940","LBMCFTDM48R1N":"0.6410","LBMCFTDM48R2N":"0.7090","LBMCFTDM48R3N":"0.6070","TB231CDM48R1N":"0.6030","TB231CDM48R2N":"0.5740","TB231CDM48R3N":"0.5530","TB231TDM48R1N":"0.5020","TB231TDM48R2N":"0.4990","TB231TDM48R3N":"0.6120","TB468CDM48R1N":"0.7630","TB468CDM48R2N":"0.8130","TB468CDM48R3N":"0.7080","TB468TDM48R1N":"0.6920","TB468TDM48R2N":"0.6170","TB468TDM48R3N":"0.7190"},{"Bin range(ppm)":"[0.45 .. 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}