{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000464","ANALYSIS_ID":"AN000725","VERSION":"1","CREATED_ON":"September 9, 2016, 12:32 pm"},

"PROJECT":{"PROJECT_TITLE":"Transpulmonary metabolomics in pulmonary arterial hypertension","PROJECT_SUMMARY":"Pulmonary arterial hypertension (PAH) is a progressive and incurable disease characterized by obliteration of the pulmonary arterioles, elevated pulmonary vascular resistance (PVR), and eventual right heart failure and death. Current medical therapy for PAH is aimed at reducing PVR by targeting pathways involved in vasodilation. Pulmonary vasodilators improve functional capacity but do not target the underlying vascular obstruction. Despite multiple approved therapies, median survival after diagnosis is less than five years, indicating that additional therapeutic targets are needed.","INSTITUTE":"Vanderbilt University","LAST_NAME":"Brittain","FIRST_NAME":"Evan","ADDRESS":"2525 West End Ave, Suite 300, Nashville TN 37203","EMAIL":"evan.brittain@Vanderbilt.Edu","PHONE":"(615) 322-2318"},

"STUDY":{"STUDY_TITLE":"Transpulmonary metabolomics in pulmonary arterial hypertension","STUDY_SUMMARY":"We hypothesize that transpulmonary metabolomic profiling will demonstrate a PAH-specific metabolic signature. We will examine organ-specific metabolism by measuring blood flowing into (pulmonary artery) and out of (pulmonary artery wedge) the pulmonary circulation at the time of right heart catheterization (RHC). We will compare PAH to patients without PH and to a disease control cohort with PH due to left heart disease (pulmonary ventrical hypertension - PVH).","INSTITUTE":"RTI International","LAST_NAME":"Sumner","FIRST_NAME":"Susan","ADDRESS":"3040 E. Cornwallis Road","EMAIL":"ssumner@rti.org","PHONE":"919-541-7479"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"P_1",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_10",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_100",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_101",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_102",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_103",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_104",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_107",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_108",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_109",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_11",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_110",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_111",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_112",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_113",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_114",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_115",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_116",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_117",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_118",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_119",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_12",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_120",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_121",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_122",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_123",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_124",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_125",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_126",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_127",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_128",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_129",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_13",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_130",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_131",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_132",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_133",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_134",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_135",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_136",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_137",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_138",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_139",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_14",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_140",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_141",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_142",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_143",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_144",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_146",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_147",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_148",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_149",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_15",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_150",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_151",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_152",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_154",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_155",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_156",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_16",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_17",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_18",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_19",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_2",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_20",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_21",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_22",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_23",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_24",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_25",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_26",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_27",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_28",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_29",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_3",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_30",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_31",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_32",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_33",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_34",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_35",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_36",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_37",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_38",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_39",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_4",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_40",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_41",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_42",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_43",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_44",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_45",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_46",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_47",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_48",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_49",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_5",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_50",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_51",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_52",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_54",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_55",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_56",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_57",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_58",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_6",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_60",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_61",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_62",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_63",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_65",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_66",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_67",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_68",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_69",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_7",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_70",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_71",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_72",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_73",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_74",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_75",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_76",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_77",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_78",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_79",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_8",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_80",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_81",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_82",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_83",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_84",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_85",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_86",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_87",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_88",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_89",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_9",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_90",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_91",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_92",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_93",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_94",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_95",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_96",
"Factors":{"Phenotype":"PAH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_97",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"P_98",
"Factors":{"Phenotype":"no PH","Plasma_Type":"PA"}
},
{
"Subject ID":"-",
"Sample ID":"P_99",
"Factors":{"Phenotype":"PVH","Plasma_Type":"PCW"}
},
{
"Subject ID":"-",
"Sample ID":"TP_1",
"Factors":{"Phenotype":"Total Pool","Plasma_Type":"Total Pool"}
},
{
"Subject ID":"-",
"Sample ID":"TP_10",
"Factors":{"Phenotype":"Total Pool","Plasma_Type":"Total Pool"}
},
{
"Subject ID":"-",
"Sample ID":"TP_2",
"Factors":{"Phenotype":"Total Pool","Plasma_Type":"Total Pool"}
},
{
"Subject ID":"-",
"Sample ID":"TP_3",
"Factors":{"Phenotype":"Total Pool","Plasma_Type":"Total Pool"}
},
{
"Subject ID":"-",
"Sample ID":"TP_4",
"Factors":{"Phenotype":"Total Pool","Plasma_Type":"Total Pool"}
},
{
"Subject ID":"-",
"Sample ID":"TP_5",
"Factors":{"Phenotype":"Total Pool","Plasma_Type":"Total Pool"}
},
{
"Subject ID":"-",
"Sample ID":"TP_6",
"Factors":{"Phenotype":"Total Pool","Plasma_Type":"Total Pool"}
},
{
"Subject ID":"-",
"Sample ID":"TP_7",
"Factors":{"Phenotype":"Total Pool","Plasma_Type":"Total Pool"}
},
{
"Subject ID":"-",
"Sample ID":"TP_8",
"Factors":{"Phenotype":"Total Pool","Plasma_Type":"Total Pool"}
},
{
"Subject ID":"-",
"Sample ID":"TP_9",
"Factors":{"Phenotype":"Total Pool","Plasma_Type":"Total Pool"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Plasma was collected from patients during right heart catheterization from the pulmonary artery (PA) and the pulmonary capillary wedge (PCW)."},

"TREATMENT":{"TREATMENT_SUMMARY":"None"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"De-identified samples were shipped to the NIH RTI-RCMRC on dry ice and immediately stored at -80 °C after being logged in for metabolomics analysis. Study samples were thawed on ice for sample preparation. A 150 µL aliquot of plasma was transferred to new labeled tubes for each study sample. A total study pool was generated by transferring 15 µL of plasma from each sample into a new 10 mL Falcon tube. The total pool sample was vortexed and 150 µL aliquots were transferred into 10 total pool-labeled tubes. Plasma and pooled samples were extracted with 450 µL methanol, vortexed for 2 min on a multi-tube vortexer, and centrifuged at 16,000 rcf for 5 min. A 400 µl aliquot of the supernatant was transferred into pre-labeled 2.0mL LoBind Eppendorf tubes, and the supernatant was lyophilized to complete dryness overnight. Samples were reconstituted with 250 µL of NMR master mix solution containing Chenomx ISTD: DSS-d6 and 0.20 M phosphate buffer at 7.4 pH. The tubes were vortexed for 2 min on a multi-tube vortexer and centrifuged at 16,000 rcf for 5 min. A 200uL aliquot of supernatants were transferred into a pre-labeled 3mm 4 NMR tubes for data acquisition on a 700 MHz spectrometer."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"-","INSTRUMENT_NAME":"-","COLUMN_NAME":"-"},

"ANALYSIS":{"ANALYSIS_TYPE":"NMR"},

"NM":{"INSTRUMENT_NAME":"Bruker Avance III","INSTRUMENT_TYPE":"FT-NMR","NMR_EXPERIMENT_TYPE":"1D-1H","SPECTROMETER_FREQUENCY":"700.13 MHz"},

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