{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000475","ANALYSIS_ID":"AN000739","VERSION":"1","CREATED_ON":"September 13, 2016, 2:12 pm"},

"PROJECT":{"PROJECT_TITLE":"Metabolomic testing of a putative MDH inhibitor","PROJECT_SUMMARY":"Testing for metabolomic changes after treatment of leukemia cells with a putative MDH inhibitor","INSTITUTE":"Case Western Reserve University","DEPARTMENT":"Pathology","LABORATORY":"Foundation and Institutional funds","LAST_NAME":"Wald","FIRST_NAME":"David","ADDRESS":"2103 Cornell Rd WRB3-530 Cleveland, OH 44106","EMAIL":"dnw@case.edu","PHONE":"NA"},

"STUDY":{"STUDY_TITLE":"Metabolomic testing of a putative MDH inhibitor (global)","STUDY_TYPE":"drug treatment (single dose and timepoint)","STUDY_SUMMARY":"HL-60 cells will be treated for 15hr with a putative MDH inhibitor or vehicle (n=5 per group)","INSTITUTE":"University of Florida","DEPARTMENT":"SECIM","LABORATORY":"Case Western University","LAST_NAME":"Wald","FIRST_NAME":"David","ADDRESS":"2103 Cornell Rd WRB3-530 Cleveland, OH 44106","EMAIL":"dnw@case.edu","PHONE":"2163685668","NUM_GROUPS":"2","TOTAL_SUBJECTS":"20","STUDY_COMMENTS":"Total subjects: 10 for global testing and 10 for targeted testing"},

"SUBJECT":{"SUBJECT_TYPE":"Human leukemia cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","CELL_STRAIN_DETAILS":"HL-60","SUBJECT_COMMENTS":"immortalized","CELL_COUNTS":"10 million per sample"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"untreat",
"Sample ID":"ut1",
"Factors":{"Treatment":"-"}
},
{
"Subject ID":"untreat",
"Sample ID":"ut2",
"Factors":{"Treatment":"-"}
},
{
"Subject ID":"untreat",
"Sample ID":"ut3",
"Factors":{"Treatment":"-"}
},
{
"Subject ID":"untreat",
"Sample ID":"ut4",
"Factors":{"Treatment":"-"}
},
{
"Subject ID":"untreat",
"Sample ID":"ut5",
"Factors":{"Treatment":"-"}
},
{
"Subject ID":"treat",
"Sample ID":"tx1",
"Factors":{"Treatment":"MDH inhib"}
},
{
"Subject ID":"treat",
"Sample ID":"tx2",
"Factors":{"Treatment":"MDH inhib"}
},
{
"Subject ID":"treat",
"Sample ID":"tx3",
"Factors":{"Treatment":"MDH inhib"}
},
{
"Subject ID":"treat",
"Sample ID":"tx4",
"Factors":{"Treatment":"MDH inhib"}
},
{
"Subject ID":"treat",
"Sample ID":"tx5",
"Factors":{"Treatment":"MDH inhib"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Cells were centrifuged to remove growth media/drug and either flash frozen or washed 1x in PBS. The cells were washed for the targeted assay but not for the global assay.","SAMPLE_TYPE":"cell","STORAGE_CONDITIONS":"flash frozen","TISSUE_CELL_QUANTITY_TAKEN":"10 million per sample"},

"TREATMENT":{"TREATMENT_SUMMARY":"Cells were treated for 15hr with 1 micromolar of drug or vehicle","CELL_GROWTH_CONTAINER":"flasks","CELL_GROWTH_RATE":"~24hr per division","CELL_MEDIA":"RPMI with 10% FBS","CELL_ENVIR_COND":"5% CO2 incubator","CELL_MEDIA_LASTCHANGED":"15 hr"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Amino Acid|Global","SAMPLEPREP_PROTOCOL_FILENAME":"SB_OA_Assay.pdf;Appendix C_Protein_DNA_quant.pdf","SAMPLE_SPIKING":"Appendix A - Internal Standard Prep GLCMS.pdf"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Global","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Thermo Scientific-Dionex Ultimate 3000","COLUMN_NAME":"ACE Excel 2 C18-PFP (100 x 2.1mm, 2um)","METHODS_FILENAME":"Consolidated_Cellular_Metabolomics_SOP.pdf"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"peak area",

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