{
"METABOLOMICS WORKBENCH":{"VERSION":"1","CREATED_ON":"November 17, 2016, 3:09 pm"},

"PROJECT":{"PROJECT_TITLE":"Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults","PROJECT_TYPE":"skeletal muscle ceramide, diacylglycerol, or amino acid metabolite levels","PROJECT_SUMMARY":"effect of caloric restriction on insulin sensitivity through skeletal muscle ceramide, diacylglycerol, or amino acid metabolite levels","INSTITUTE":"Mayo Clinic","DEPARTMENT":"Endocrinology","LABORATORY":"Mayo Clinic Metabolomics Resource Core","LAST_NAME":"Nair","FIRST_NAME":"Sreekumaran","ADDRESS":"200 First Street SW, Rochester, MN 55905","EMAIL":"Nair.K@mayo.edu","PHONE":"507-285-2415"},

"STUDY":{"STUDY_TITLE":"Amino Acid Quantifcation of obese patients on a 16 week caloric restriction from muscle biopsy (part II)","STUDY_TYPE":"timecourse, quantitative measurements of amino acid","STUDY_SUMMARY":"Caloric restriction (CR) improves insulin sensitivity and reduces the incidence of diabetes in obese individuals. The underlying mechanisms whereby CR improves insulin sensitivity are not clear. We evaluated the effect of 16 weeks of CR on whole-body insulin sensitivity by pancreatic clamp before and after CR in 11 obese participants (BMI = 35 kg/m2) compared with 9 matched control subjects (BMI = 34 kg/m2). Compared with the control subjects, CR increased the glucose infusion rate needed to maintain euglycemia during hyperinsulinemia, indicating enhancement of peripheral insulin sensitivity. This improvement in insulin sensitivity was not accompanied by changes in skeletal muscle mitochondrial oxidative capacity or oxidant emissions, nor were there changes in skeletal muscle ceramide, diacylglycerol, or amino acid metabolite levels. However, CR lowered insulin-stimulated thioredoxin-interacting protein (TXNIP) levels and enhanced nonoxidative glucose disposal. These results support a role for TXNIP in mediating the improvement in peripheral insulin sensitivity after CR.","INSTITUTE":"Mayo Clinic","DEPARTMENT":"Endocrinology","LABORATORY":"Mayo Clinic Metabolomics Resource Core","LAST_NAME":"Nair","FIRST_NAME":"Sreekumaran","ADDRESS":"200 First Street SW, Rochester, MN 55905","EMAIL":"Nair.K@mayo.edu","PHONE":"507-285-2415"},

"SUBJECT":{"SUBJECT_TYPE":"Animal","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"s1",
"Sample ID":"ms5370-1",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"16","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s1",
"Sample ID":"ms5370-2",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"15.9","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s2",
"Sample ID":"ms5370-3",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"24.1","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s2",
"Sample ID":"ms5370-4",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"16","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s3",
"Sample ID":"ms5370-5",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"17.6","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s3",
"Sample ID":"ms5370-6",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"10.6","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s4",
"Sample ID":"ms5370-7",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"21.8","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s4",
"Sample ID":"ms5370-8",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"13.4","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s5",
"Sample ID":"ms5370-9",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"13.1","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s5",
"Sample ID":"ms5370-10",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"11.8","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s6",
"Sample ID":"ms5370-11",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"19.7","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s6",
"Sample ID":"ms5370-12",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"14.5","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s7",
"Sample ID":"ms5370-13",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"12.6","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s7",
"Sample ID":"ms5370-14",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"21.3","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s8",
"Sample ID":"ms5370-15",
"Factors":{"Time (mins) (mins)":"1","Category":"Control"},
"Additional sample data":{"mg tissue":"24.9","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s8",
"Sample ID":"ms5370-16",
"Factors":{"Time (mins) (mins)":"2","Category":"Control"},
"Additional sample data":{"mg tissue":"17.3","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s9",
"Sample ID":"ms5370-17",
"Factors":{"Time (mins) (mins)":"1","Category":"Control"},
"Additional sample data":{"mg tissue":"11.8","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s9",
"Sample ID":"ms5370-18",
"Factors":{"Time (mins) (mins)":"2","Category":"Control"},
"Additional sample data":{"mg tissue":"14.3","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s10",
"Sample ID":"ms5370-19",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"17","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s10",
"Sample ID":"ms5370-20",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"14","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s11",
"Sample ID":"ms5370-21",
"Factors":{"Time (mins) (mins)":"1","Category":"Control"},
"Additional sample data":{"mg tissue":"24.6","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s11",
"Sample ID":"ms5370-22",
"Factors":{"Time (mins) (mins)":"2","Category":"Control"},
"Additional sample data":{"mg tissue":"20.9","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s12",
"Sample ID":"ms5370-23",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"20","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s12",
"Sample ID":"ms5370-24",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"18.5","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s13",
"Sample ID":"ms5370-25",
"Factors":{"Time (mins) (mins)":"1","Category":"Control"},
"Additional sample data":{"mg tissue":"20.7","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s13",
"Sample ID":"ms5370-26",
"Factors":{"Time (mins) (mins)":"2","Category":"Control"},
"Additional sample data":{"mg tissue":"25.1","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s14",
"Sample ID":"ms5370-27",
"Factors":{"Time (mins) (mins)":"1","Category":"Control"},
"Additional sample data":{"mg tissue":"22.1","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s14",
"Sample ID":"ms5370-28",
"Factors":{"Time (mins) (mins)":"2","Category":"Control"},
"Additional sample data":{"mg tissue":"20.5","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s15",
"Sample ID":"ms5370-29",
"Factors":{"Time (mins) (mins)":"1","Category":"Control"},
"Additional sample data":{"mg tissue":"15.8","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s15",
"Sample ID":"ms5370-30",
"Factors":{"Time (mins) (mins)":"2","Category":"Control"},
"Additional sample data":{"mg tissue":"11.2","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s16",
"Sample ID":"ms5370-31",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"12.9","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s16",
"Sample ID":"ms5370-32",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"21.6","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s17",
"Sample ID":"ms5370-33",
"Factors":{"Time (mins) (mins)":"1","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"12.3","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s17",
"Sample ID":"ms5370-34",
"Factors":{"Time (mins) (mins)":"2","Category":"Caloric Restriction"},
"Additional sample data":{"mg tissue":"24.7","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s18",
"Sample ID":"ms5370-35",
"Factors":{"Time (mins) (mins)":"1","Category":"Control"},
"Additional sample data":{"mg tissue":"16.4","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s18",
"Sample ID":"ms5370-36",
"Factors":{"Time (mins) (mins)":"2","Category":"Control"},
"Additional sample data":{"mg tissue":"12.1","sample type":"muscle","Sex":"M"}
},
{
"Subject ID":"s19",
"Sample ID":"ms5370-37",
"Factors":{"Time (mins) (mins)":"1","Category":"Control"},
"Additional sample data":{"mg tissue":"17.4","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s19",
"Sample ID":"ms5370-38",
"Factors":{"Time (mins) (mins)":"2","Category":"Control"},
"Additional sample data":{"mg tissue":"22.6","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s20",
"Sample ID":"ms5370-39",
"Factors":{"Time (mins) (mins)":"1","Category":"Control"},
"Additional sample data":{"mg tissue":"27","sample type":"muscle","Sex":"F"}
},
{
"Subject ID":"s20",
"Sample ID":"ms5370-40",
"Factors":{"Time (mins) (mins)":"2","Category":"Control"},
"Additional sample data":{"mg tissue":"16.5","sample type":"muscle","Sex":"F"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Blood samples were collected in a heated hotbox (131°F) through a retrograde intravenous catheter at baseline for glucose and hormone levels, and every 10 min during the clamp to maintain euglycemia. In addition, blood samples were collected every 20 min from 0600 to 0700, 0900 to 1000, and 1200 to 1300 to measure plasma [6,62H2]glucose. At 1330 h, a percutaneous needle muscle biopsy specimen (350–400 mg) was obtained from the vastus lateralis muscle under local anesthesia, immediately frozen in liquid nitrogen, and stored at −80°F for future analysis (27). This biopsy sample was used for analysis of TXNIP mRNA and protein content. The participant remained in the CRU through the remainder of the day and was given a weight-maintenance diet until 2200 h. At 0700 h the following morning, a second muscle biopsy specimen was obtained under local anesthesia, and ∼100 mg was used immediately for mitochondrial function measurements of isolated mitochondria and mtH2O2 emissions (28). The remainder was immediately frozen in liquid nitrogen and stored at −80°F for future analysis, including DAG, ceramide, and amino acid measurements (Fig. 1).","SAMPLE_TYPE":"Muscle"},

"TREATMENT":{"TREATMENT_SUMMARY":"Before and after 16 weeks of CR or CON, two outpatient visits and one inpatient visit were scheduled. Before the outpatient visits, participants were instructed to fast overnight from 10:00 p.m. the evening before and to avoid strenuous exercise for 24 h preceding the visits. One outpatient visit consisted of an MRI to measure subcutaneous and visceral fat distribution and magnetic resonance spectroscopy to measure skeletal muscle oxidative capacity (25). The second outpatient visit was for measurements of resting energy expenditure (REE) for the calculation of a weight-maintenance diet (Parvo Medics TrueOne 2400 Canopy system), DEXA scan (Lunar DPX-L; Lunar Radiation, Madison, WI), and VO2peak test on a bicycle ergometer (Fig. 1). Participants were admitted to the Clinical Research Unit (CRU) on the evening of the fifth day of the weight-maintaining diet provided by the CRU metabolic kitchen (Supplementary Fig. 1). The weight-maintenance meals (diet composition: 20% protein, 30% fat, 50% carbohydrate) were monitored daily to ensure that the correct calorie level was achieved. Upon admission to the CRU, no calories were consumed after 2100 h to achieve a 10-h fast before the two-stage insulin euglycemic pancreatic clamp the following morning, as previously published (26), with modifications as follows: the following morning at 0400 h, a primed [6,62H2]glucose bolus (6 mg ⋅ kg fat-free mass[FFM]−1) was administered, followed by a 9-h continuous infusion of [6,62H2]glucose (started at 4 mg ⋅ kgFFM−1 ⋅ h−1 then titrated downward over the infusion time period to match anticipated changes in endogenous glucose production [EGP]). At 0600 h, gas exchange was measured by indirect calorimetry for 30 min for REE determination. Then at 0700 h, glucagon (0.001 μg ⋅ kgFFM−1 ⋅ min−1), somatostatin (0.093 μg ⋅ kgFFM−1 ⋅ min−1), and growth hormone (0.0047 μg ⋅ kgFFM−1 ⋅ min−1) were infused for 6 h. Insulin was infused from 0700 to 1000 h at 0.62 mU ⋅ kgFFM−1 ⋅ min−1 and then from 1000 to 1300 h at 2.3 mU ⋅ kgFFM−1 ⋅ min−1. A 40% dextrose with 2% enrichment of [6,62H2]glucose was infused as needed to maintain blood glucose above 4.7 mmol/L from 0700 to 1000 h and then between 4.7 and 5.3 mmol/L from 1000 to 1300 h."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"All measurements were made on the second biopsy sample taken after an overnight fast. Concentrations of amino acids and metabolites were determined using MassTrak Amino Acid Solution (Waters) modified for mass spectrometry as previously described (32). Muscle samples were spiked with internal standards for amino acids and metabolites, deproteinated using cold methanol, and centrifuged."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"High resolution separation was done using an Acquity UPLC system, injecting 1 µl of derviatized solution, with a UPLC BEH C18 1.7 micron 2.1×150 mm column from Waters. Column flow was set to 400 µl/min with a gradient from 99.9%A to 98%B where buffer A is 1% acetonitrile in 0.1% formic acid and buffer B is 100% acetonitrile. A column temp of 43 degrees Celsius and a sample tray temp of 6% Celsius. Mass detection was completed on a TSQ Ultra Quantum from Thermo Finnigan running in ESI positive mode. A scan width of 0.002, scan time of 0.04 seconds per transition mass, collision energy of 25, collision gas pressure of 1.5 mTorr, tube lens value set to 90, monitoring a signature ion of the derivitized amines at m/z 171.04 by selected reaction monitoring.","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Thermo Quantum Ultra","COLUMN_NAME":"C18"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Thermo Quantum Ultra","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"micromolar",

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"Metabolites":[{"metabolite_name":"Histidine"},{"metabolite_name":"Hydroxyproline"},{"metabolite_name":"1-Methylhistidine"},{"metabolite_name":"3-Methylhistidine"},{"metabolite_name":"Phosphoethanolamine"},{"metabolite_name":"Carnosine"},{"metabolite_name":"Anserine"},{"metabolite_name":"Ethanolamine"},{"metabolite_name":"Aspartic Acid"},{"metabolite_name":"Sarcosine"},{"metabolite_name":"beta-Alanine"},{"metabolite_name":"gamma-Amino-N-butyric-acid"},{"metabolite_name":"alpha-Aminoadipic-acid"},{"metabolite_name":"beta-Aminoisobutyric-acid"},{"metabolite_name":"Hydroxylysine 1"},{"metabolite_name":"Hydroxylysine 2"},{"metabolite_name":"alpha-Amino-N-butyric-acid"},{"metabolite_name":"Cystathionine 1"},{"metabolite_name":"Cystathionine 2"},{"metabolite_name":"Methionine"},{"metabolite_name":"allo-Isoleucine"},{"metabolite_name":"Homocystine"},{"metabolite_name":"Asparagine"},{"metabolite_name":"Arginine"},{"metabolite_name":"Taurine"},{"metabolite_name":"Serine"},{"metabolite_name":"Glutamine"},{"metabolite_name":"Glycine"},{"metabolite_name":"Citrulline"},{"metabolite_name":"Glutamic Acid"},{"metabolite_name":"Threonine"},{"metabolite_name":"Alanine"},{"metabolite_name":"Proline"},{"metabolite_name":"Ornithine"},{"metabolite_name":"Lysine"},{"metabolite_name":"Cystine"},{"metabolite_name":"Tyrosine"},{"metabolite_name":"Valine"},{"metabolite_name":"Isoleucine"},{"metabolite_name":"Leucine"},{"metabolite_name":"Phenylalanine"},{"metabolite_name":"Tryptophan"}]
}

}