{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000507","ANALYSIS_ID":"AN000776","VERSION":"1","CREATED_ON":"November 29, 2016, 3:20 pm"},

"PROJECT":{"PROJECT_TITLE":"Metabolic Dissection of Aberrant Glutamine Metabolism in Prostate Cancer","PROJECT_TYPE":"MS targeted analysis","PROJECT_SUMMARY":"In this project, we propose to define the specific role(s) of three crucial oncogenic signaling cascades (androgen receptor, Myc and AMPK) in regulating glutamine metabolism in prostate cancer using 13C-labeled glutamine with mass spectrometry-based metabolic flux analyses.","INSTITUTE":"Mayo Clinic","LABORATORY":"Mayo Clinic Metabolomics Resource Core","LAST_NAME":"Frigo","FIRST_NAME":"Daniel","ADDRESS":"Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204-5001","EMAIL":"frigo@uh.edu","PHONE":"832-842-8824"},

"STUDY":{"STUDY_TITLE":"Timecourse of TCA isotopomers in LNCaP Cells","STUDY_SUMMARY":"Timecourse of TCA isotopomers in LNCaP Cells","INSTITUTE":"Mayo Clinic","LABORATORY":"Mayo Clinic Metabolomics Resource Core","LAST_NAME":"Frigo","FIRST_NAME":"Daniel","ADDRESS":"Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204-5001","EMAIL":"frigo@uh.edu","PHONE":"832-842-8824"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"DF-1",
"Factors":{"Time (incubation)":"24 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":"1 15cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-2",
"Factors":{"Time (incubation)":"24 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":"1 15cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-3",
"Factors":{"Time (incubation)":"24 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":".5 15cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-4",
"Factors":{"Time (incubation)":"24 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":".5 15cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-5",
"Factors":{"Time (incubation)":"24 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":"1 10cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-6",
"Factors":{"Time (incubation)":"24 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":"1 10cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-7",
"Factors":{"Time (incubation)":"24 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":".5 10cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-8",
"Factors":{"Time (incubation)":"24 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":".5 10cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-9",
"Factors":{"Time (incubation)":"72 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":"1 15cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-10",
"Factors":{"Time (incubation)":"72 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":"1 15cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-11",
"Factors":{"Time (incubation)":"72 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":".5 15cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-12",
"Factors":{"Time (incubation)":"72 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":".5 15cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-13",
"Factors":{"Time (incubation)":"72 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":"1 10cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-14",
"Factors":{"Time (incubation)":"72 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":"1 10cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-15",
"Factors":{"Time (incubation)":"72 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":".5 10cm2 dish"}
},
{
"Subject ID":"-",
"Sample ID":"DF-16",
"Factors":{"Time (incubation)":"72 hours"},
"Additional sample data":{"Description":"LNCaP cell pellet-untreated","Amount":".5 10cm2 dish"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"LNCaP cell models"},

"TREATMENT":{"TREATMENT_SUMMARY":"LNCaP cells that were untreated."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"TCA isotopomers","SAMPLEPREP_PROTOCOL_COMMENTS":"cells incubated in U-13C5-glutamine containing media"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Agilent 7890A","COLUMN_NAME":"Agilent HP5-MS (30m × 0.25mm, 0.25 um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 5975C","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"EI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"% enrichment",

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}

}