{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000834","ANALYSIS_ID":"AN001335","VERSION":"1","CREATED_ON":"October 3, 2017, 9:37 am"},

"PROJECT":{"PROJECT_TITLE":"Purine and TCA Measurements in SS Hypertension","PROJECT_TYPE":"MS analysis","PROJECT_SUMMARY":"Based on RNA-seq ontological and Bayesian analyses, both purine levels and TCA-cycle intermediates have been nominated as being regulated by pressure in the SS rat. This project seeks to verify the previous RNA-seq prediction.","INSTITUTE":"Medical College of Wisconsin","DEPARTMENT":"Physiology","LABORATORY":"Cowley Lab","LAST_NAME":"Cowley","FIRST_NAME":"Allen","ADDRESS":"Milwaukee, WI","EMAIL":"cowley@mcw.edu","PHONE":"414-955-8277"},

"STUDY":{"STUDY_TITLE":"Purine and TCA measurements in salt sensitive (SS) hypertension","STUDY_TYPE":"MS analysis","STUDY_SUMMARY":"SS rats were surgically implanted with a chronic servo-control cuff, the purpose of which is to maintain normal pressure to the left kidney while the right kidney is exposed to high blood pressure. After 7 days of high salt treatment, which induces high blood pressure in the SS rat, rats were anesthetized with pentobarbital, kidneys were flushed and removed. The renal medulla was separated from the cortex using scissors, and the renal medullas were frozen in liquid nitrogen and stored at -80 C.","INSTITUTE":"University of Michigan","DEPARTMENT":"Biomedical Research Core Facilities","LABORATORY":"Metabolomics core","LAST_NAME":"Kachman","FIRST_NAME":"Maureen","ADDRESS":"6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714","EMAIL":"mkachman@med.umich.edu","PHONE":"(734) 232-8175","NUM_GROUPS":"11","TOTAL_SUBJECTS":"4"},

"SUBJECT":{"SUBJECT_TYPE":"RAT","SUBJECT_SPECIES":"Rattus norvegicus","TAXONOMY_ID":"10114"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"SU0016139",
"Sample ID":"S00025608",
"Factors":{"Side":"Left"},
"Additional sample data":{"BP (mmHg)":"127.0","Rat":"1"}
},
{
"Subject ID":"SU0016139",
"Sample ID":"S00025609",
"Factors":{"Side":"Right"},
"Additional sample data":{"BP (mmHg)":"147.0","Rat":"1"}
},
{
"Subject ID":"SU0016141",
"Sample ID":"S00025610",
"Factors":{"Side":"Left"},
"Additional sample data":{"BP (mmHg)":"128.0","Rat":"2"}
},
{
"Subject ID":"SU0016141",
"Sample ID":"S00025611",
"Factors":{"Side":"Right"},
"Additional sample data":{"BP (mmHg)":"147.0","Rat":"2"}
},
{
"Subject ID":"SU0016143",
"Sample ID":"S00025612",
"Factors":{"Side":"Left"},
"Additional sample data":{"BP (mmHg)":"124.0","Rat":"3"}
},
{
"Subject ID":"SU0016143",
"Sample ID":"S00025613",
"Factors":{"Side":"Right"},
"Additional sample data":{"BP (mmHg)":"149.0","Rat":"3"}
},
{
"Subject ID":"SU0016145",
"Sample ID":"S00025614",
"Factors":{"Side":"Left"},
"Additional sample data":{"BP (mmHg)":"n/a","Rat":"n/a"}
},
{
"Subject ID":"SU0016145",
"Sample ID":"S00025615",
"Factors":{"Side":"Right"},
"Additional sample data":{"BP (mmHg)":"n/a","Rat":"n/a"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"-"},

"TREATMENT":{"TREATMENT_SUMMARY":"-"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"-","SAMPLEPREP_PROTOCOL_FILENAME":"A011_Glycolysis-TCA-nucleotides.pdf"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"5% Phenyl Methyl Siloxane","CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Agilent 7890N","COLUMN_NAME":"Agilent HP5-MS (15m × 0.25mm, 0.25 um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","ANALYSIS_PROTOCOL_FILE":"A011 - Glycolysis-TCA-nucleotides.pdf","ACQUISITION_PARAMETERS_FILE":"HEIDI_FAMES_10MIN.M.zip"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 5975","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"EI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"nmol/mg",

"Data":[{"Metabolite":"PHOSPHOENOLPYRUVATE","S00025608":"","S00025609":"","S00025610":"","S00025611":"0.002238075","S00025612":"0.002936561","S00025613":"0.001497128","S00025614":"0.001079579","S00025615":"0.001768693"},{"Metabolite":"D-ERYTHROSE 4-PHOSPHATE","S00025608":"0.014010332","S00025609":"0.016984821","S00025610":"","S00025611":"0.01526438","S00025612":"","S00025613":"0.052889418","S00025614":"0.036581065","S00025615":"0.000853245"},{"Metabolite":"BETA-NAD+","S00025608":"0.06374692","S00025609":"0.0700109","S00025610":"0.054146377","S00025611":"0.067540817","S00025612":"0.08577401","S00025613":"0.133515745","S00025614":"0.09906959","S00025615":"0.091508614"},{"Metabolite":"COENZYME II","S00025608":"0.009813115","S00025609":"0.009884822","S00025610":"0.014766304","S00025611":"0.0121121","S00025612":"0.012978596","S00025613":"0.007816356","S00025614":"0.008386053","S00025615":"0.012208726"},{"Metabolite":"SEDOHEPTULOSE 7-PHOSPHATE","S00025608":"0.083986073","S00025609":"0.077729168","S00025610":"0.061124042","S00025611":"0.098403809","S00025612":"0.10426337","S00025613":"0.070846085","S00025614":"0.072724669","S00025615":"0.087073947"},{"Metabolite":"D-FRUCTOSE, 1,6-BIS(DIHYDROGEN PHOSPHATE)","S00025608":"0.013320433","S00025609":"0.014285476","S00025610":"0.016721931","S00025611":"0.014346555","S00025612":"0.019849205","S00025613":"0.018468204","S00025614":"0.012829552","S00025615":"0.017093124"},{"Metabolite":"NADP-REDUCED","S00025608":"0.008387778","S00025609":"0.008428906","S00025610":"0.007512053","S00025611":"0.009540162","S00025612":"0.011727217","S00025613":"0.00976995","S00025614":"0.007538922","S00025615":"0.008385149"},{"Metabolite":"CITRIC ACID","S00025608":"0.030662316","S00025609":"0.022396995","S00025610":"0.011537887","S00025611":"0.021981468","S00025612":"0.012954692","S00025613":"0.033076688","S00025614":"0.017976974","S00025615":"0.013836711"},{"Metabolite":"NADH","S00025608":"0.017926504","S00025609":"0.022909499","S00025610":"","S00025611":"0.024443716","S00025612":"","S00025613":"0.018134525","S00025614":"0.018851791","S00025615":""},{"Metabolite":"MALIC ACID","S00025608":"0.022499058","S00025609":"0.021519623","S00025610":"0.080753346","S00025611":"0.027962912","S00025612":"0.026168585","S00025613":"0.023875585","S00025614":"0.017976334","S00025615":"0.040948187"},{"Metabolite":"ADENOSINE TRIPHOSPHATE","S00025608":"0.152075649","S00025609":"0.287947471","S00025610":"0.061864497","S00025611":"0.24955847","S00025612":"0.230327265","S00025613":"0.163777487","S00025614":"0.143692973","S00025615":"0.178190663"},{"Metabolite":"SUCROSE","S00025608":"0.010345131","S00025609":"0.012354612","S00025610":"0.022875568","S00025611":"0.014202025","S00025612":"0.01962373","S00025613":"0.013422085","S00025614":"0.008699082","S00025615":"0.022132336"},{"Metabolite":"ADENOSINE 5'-DIPHOSPHATE","S00025608":"0.089739374","S00025609":"0.096910332","S00025610":"0.04465881","S00025611":"0.09643351","S00025612":"0.075164528","S00025613":"0.053531037","S00025614":"0.060481792","S00025615":"0.063066025"},{"Metabolite":"GLYCERATE 3-PHOSPHATE","S00025608":"0.159103562","S00025609":"0.175000564","S00025610":"0.152744093","S00025611":"0.202390679","S00025612":"0.296113929","S00025613":"2.481637296","S00025614":"0.317153825","S00025615":"0.295905343"},{"Metabolite":"RIBOSE PHOSPHATE","S00025608":"0.02365829","S00025609":"0.027799435","S00025610":"0.030244893","S00025611":"0.026928424","S00025612":"0.040660352","S00025613":"0.05223231","S00025614":"0.026300231","S00025615":"0.033856338"},{"Metabolite":"6-PHOSPHOGLUCONIC ACID","S00025608":"0.009685428","S00025609":"0.011277527","S00025610":"0.013712325","S00025611":"0.010531027","S00025612":"0.016499074","S00025613":"0.009863179","S00025614":"0.009594665","S00025615":"0.01428308"}],

"Metabolites":[{"Metabolite":"PHOSPHOENOLPYRUVATE","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"1005","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"D-ERYTHROSE 4-PHOSPHATE","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"122357","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"BETA-NAD+","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"15938971","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"COENZYME II","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"15938972","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"SEDOHEPTULOSE 7-PHOSPHATE","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"165007","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"D-FRUCTOSE, 1,6-BIS(DIHYDROGEN PHOSPHATE)","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"21125049","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"NADP-REDUCED","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"22833512","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"CITRIC ACID","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"311","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"NADH","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"439153","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"MALIC ACID","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"525","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"ADENOSINE TRIPHOSPHATE","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"5957","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"SUCROSE","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"5988","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"ADENOSINE 5'-DIPHOSPHATE","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"6022","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"GLYCERATE 3-PHOSPHATE","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"724","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"RIBOSE PHOSPHATE","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"77982","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""},{"Metabolite":"6-PHOSPHOGLUCONIC ACID","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"91493","inchi_key":"","kegg_id":"","other_id":"","other_id_type":""}]
}

}