{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000836","ANALYSIS_ID":"AN001339","VERSION":"1","CREATED_ON":"August 9, 2017, 9:52 am"},

"PROJECT":{"PROJECT_TITLE":"Lean Obese Human Glucose Metabolism","PROJECT_TYPE":"MS analysis","PROJECT_SUMMARY":"Lean and obese skeletal muscle TCA plus response to OGTT","INSTITUTE":"Ohio University","DEPARTMENT":"Biomedical Sciences","LABORATORY":"Consitt Lab","LAST_NAME":"Consitt","FIRST_NAME":"Leslie","ADDRESS":"Athens, Ohio","EMAIL":"consitt@ohio.edu","PHONE":"252-367-9228"},

"STUDY":{"STUDY_TITLE":"Pilot Human Muscle oral glucose tolerance test (OGTT)","STUDY_TYPE":"MS analysis","STUDY_SUMMARY":"Obesity is associated with metabolic inflexibility, the inability to switch from lipid to glucose oxidation during physiological conditions favoring excess glucose and insulin, which could contribute to the increased incidence of type 2 diabetes. Despite this knowledge, the role of skeletal muscle metabolites during these physiological conditions remain unclear and warrant further investigation. The purpose of this pilot study is to determine if: 1) there are differences in skeletal muscle glycolysis and TCA metabolites and amino acids between lean and obese individuals in the fasted state, and 2) if these metabolites change after 50 min of glucose ingestion, and 3) if there are differences in these metabolites between lean and obese individuals after 50 min of glucose ingestion.","INSTITUTE":"University of Michigan","DEPARTMENT":"Biomedical Research Core Facilities","LABORATORY":"Metabolomics core","LAST_NAME":"Kachman","FIRST_NAME":"Maureen","ADDRESS":"6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714","EMAIL":"mkachman@med.umich.edu","PHONE":"(734) 232-8175","NUM_GROUPS":"5","TOTAL_SUBJECTS":"6"},

"SUBJECT":{"SUBJECT_TYPE":"HUMAN","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"SU0019613",
"Sample ID":"S00028061",
"Factors":{"Body Comp":"Lean","Gender":"Female","Timepoint":"Baseline"}
},
{
"Subject ID":"SU0019613",
"Sample ID":"S00028062",
"Factors":{"Body Comp":"Lean","Gender":"Female","Timepoint":"50min"}
},
{
"Subject ID":"SU0019614",
"Sample ID":"S00028063",
"Factors":{"Body Comp":"Lean","Gender":"Female","Timepoint":"Baseline"}
},
{
"Subject ID":"SU0019614",
"Sample ID":"S00028064",
"Factors":{"Body Comp":"Lean","Gender":"Female","Timepoint":"50min"}
},
{
"Subject ID":"SU0019615",
"Sample ID":"S00028065",
"Factors":{"Body Comp":"Obese","Gender":"Female","Timepoint":"Baseline"}
},
{
"Subject ID":"SU0019615",
"Sample ID":"S00028066",
"Factors":{"Body Comp":"Obese","Gender":"Female","Timepoint":"50min"}
},
{
"Subject ID":"SU0019616",
"Sample ID":"S00028067",
"Factors":{"Body Comp":"Obese","Gender":"Female","Timepoint":"Baseline"}
},
{
"Subject ID":"SU0019616",
"Sample ID":"S00028068",
"Factors":{"Body Comp":"Obese","Gender":"Female","Timepoint":"50min"}
},
{
"Subject ID":"SU0019617",
"Sample ID":"S00028069",
"Factors":{"Body Comp":"Lean","Gender":"Female","Timepoint":"Baseline"}
},
{
"Subject ID":"SU0019618",
"Sample ID":"S00028070",
"Factors":{"Body Comp":"Obese","Gender":"Female","Timepoint":"Baseline"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"-"},

"TREATMENT":{"TREATMENT_SUMMARY":"-"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"-","SAMPLEPREP_PROTOCOL_FILENAME":"A043-TCA-Plus-20170713.pdf"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Agilent","COLUMN_NAME":"Phenomenex Luna NH2 (150 x 1mm, 3um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","ANALYSIS_PROTOCOL_FILE":"A043-TCA-Plus-20170713.pdf"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 6520B QTOF","INSTRUMENT_TYPE":"QTOF","MS_TYPE":"ESI","ION_MODE":"NEGATIVE"},

"MS_METABOLITE_DATA":{
"Units":"nmol/mg",

"Data":[{"Metabolite":"PHOSPHOENOLPYRUVATE","S00028061":".00213128","S00028062":".001952572","S00028063":".001018092","S00028064":".000623999","S00028065":".000801788","S00028066":".001492632","S00028067":".001002816","S00028068":".000948342","S00028069":".001708273","S00028070":".000767851"},{"Metabolite":"D-ERYTHROSE 4-PHOSPHATE","S00028061":".12203673","S00028062":".115307476","S00028063":".126482161","S00028064":".118342766","S00028065":".051992602","S00028066":".074629928","S00028067":".083051331","S00028068":".061730827","S00028069":".122757198","S00028070":".111914909"},{"Metabolite":"COENZYME II","S00028061":".000632701","S00028062":".000547026","S00028063":".000382718","S00028064":".000199346","S00028065":".000317612","S00028066":".000317304","S00028067":".00032002","S00028068":".000370228","S00028069":".000385569","S00028070":".000278579"},{"Metabolite":"D-FRUCTOSE, 1,6-BIS(DIHYDROGEN PHOSPHATE)","S00028061":".003366351","S00028062":".021479301","S00028063":".003814524","S00028064":".004759143","S00028065":".004974825","S00028066":".002320589","S00028067":".002732335","S00028068":".011600636","S00028069":".052668641","S00028070":".005712172"},{"Metabolite":"CITRIC ACID","S00028061":".002334123","S00028062":".00271885","S00028063":".002116017","S00028064":".000389616","S00028065":".001573469","S00028066":".000903126","S00028067":".000964798","S00028068":".002162508","S00028069":".0000465561","S00028070":".000968461"},{"Metabolite":"NADH","S00028061":"","S00028062":".000824558","S00028063":"","S00028064":".000898759","S00028065":"","S00028066":"","S00028067":"","S00028068":".000834729","S00028069":".001808218","S00028070":".000590548"},{"Metabolite":"FAD","S00028061":".0007391","S00028062":".000615354","S00028063":".000392966","S00028064":".000234917","S00028065":".000335183","S00028066":".00034329","S00028067":".000377112","S00028068":".000540439","S00028069":".000661625","S00028070":".000328524"},{"Metabolite":"MALIC ACID","S00028061":".029181517","S00028062":".023555064","S00028063":".019282136","S00028064":".032809597","S00028065":".016214858","S00028066":".027312525","S00028067":".009975294","S00028068":".012300151","S00028069":".080148141","S00028070":".026913984"},{"Metabolite":"ADENOSINE TRIPHOSPHATE","S00028061":".003013033","S00028062":".008371785","S00028063":".004155997","S00028064":".004881207","S00028065":".002007809","S00028066":".005683393","S00028067":".00299616","S00028068":".014967599","S00028069":".008340835","S00028070":".00583805"},{"Metabolite":"ROBISON ESTER","S00028061":".145237678","S00028062":".139315113","S00028063":".156587551","S00028064":".139901695","S00028065":".062044801","S00028066":".091301772","S00028067":".11256106","S00028068":".167120144","S00028069":".156886935","S00028070":".140506844"},{"Metabolite":"SUCROSE","S00028061":".003147867","S00028062":".006290595","S00028063":".005655238","S00028064":".003730913","S00028065":".005841245","S00028066":".004119574","S00028067":".005654122","S00028068":".003045462","S00028069":".012105958","S00028070":".009566778"},{"Metabolite":"ADENOSINE 5'-DIPHOSPHATE","S00028061":".002445498","S00028062":".004092243","S00028063":".001924469","S00028064":".001567872","S00028065":".001191739","S00028066":".003342891","S00028067":".002994112","S00028068":".005112023","S00028069":".010152059","S00028070":".002758972"},{"Metabolite":"ADENOSINE 5'-MONOPHOSPHATE","S00028061":".001058294","S00028062":".000583199","S00028063":".00038879","S00028064":".000241391","S00028065":".00030374","S00028066":".000335125","S00028067":".000989887","S00028068":".000325938","S00028069":".000533163","S00028070":".000294118"},{"Metabolite":"GLYCERATE 3-PHOSPHATE","S00028061":".026719194","S00028062":".054165394","S00028063":".042736463","S00028064":".014043179","S00028065":".04169143","S00028066":".03664765","S00028067":".005766129","S00028068":".025400285","S00028069":".042661625","S00028070":".021169164"},{"Metabolite":"RIBOSE PHOSPHATE","S00028061":".002874408","S00028062":".00328537","S00028063":".002460273","S00028064":".002026962","S00028065":".00642201","S00028066":".004256272","S00028067":".002409242","S00028068":".002235516","S00028069":".005198706","S00028070":".002006937"},{"Metabolite":"6-PHOSPHOGLUCONIC ACID","S00028061":".001209242","S00028062":".001047428","S00028063":".000659666","S00028064":".000363254","S00028065":".000572441","S00028066":".000533254","S00028067":".000638889","S00028068":".000449263","S00028069":".000483601","S00028070":".000477617"}],

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}

}