{ "METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000957","ANALYSIS_ID":"AN001571","VERSION":"1","CREATED_ON":"April 19, 2018, 1:26 pm"}, "PROJECT":{"PROJECT_TITLE":"Human milk metabolomics and microb-host interactions associated with pediatric obesity","PROJECT_TYPE":"observational longitudinal human study","PROJECT_SUMMARY":"Pediatric obesity has more than doubled in children and tripled in adolescents over the past 30 years. Recent findings demonstrate that differences in energy harvesting bacteria promote obesity in the host and appear to be influenced by early life factors such as mode of delivery, maternal obesity, and breastfeeding. The goal of this proposal is to investigate how human milk impacts the infant gut microbiome during the first 12-months of life and identify the microbe-host interactions that mediates the protective role of breastfeeding on infant adiposity. The results of this exploratory study will characterize factors that influence microbial transmission between mothers and offspring and identify human milk compounds that stabilize a healthy infant microbiome with potential to reduce pediatric obesity.","INSTITUTE":"University of Florida","DEPARTMENT":"Health Outcomes and Policy","LABORATORY":"R1-187","LAST_NAME":"Lemas","FIRST_NAME":"Dominick","ADDRESS":"Clinical and Translational Research Building, University of Florida College of Medicine, 2004 Mowry Road, Rm 2234, Gainesville, FL 32608","EMAIL":"djlemas@ufl.edu","PHONE":"352-294-5971","FUNDING_SOURCE":"Start-up Funds"}, "STUDY":{"STUDY_TITLE":"Global metabolomics of human milk fractions","STUDY_TYPE":"cross sectional","STUDY_SUMMARY":"Pediatric obesity has more than doubled in children and tripled in adolescents over the past 30 years. Recent findings demonstrate that differences in energy harvesting bacteria promote obesity in the host and appear to be influenced by early life factors such as mode of delivery, maternal obesity, and breastfeeding. The goal of this proposal is to investigate how human milk impacts the infant gut microbiome during the first 12-months of life and identify the microbe-host interactions that mediates the protective role of breastfeeding on infant adiposity. The results of this exploratory study will characterize factors that influence microbial transmission between mothers and offspring and identify human milk compounds that stabilize a healthy infant microbiome with potential to reduce pediatric obesity.","INSTITUTE":"University of Florida","DEPARTMENT":"SECIM","LABORATORY":"R1-187","LAST_NAME":"Carney","FIRST_NAME":"Olivia","ADDRESS":"Clinical and Translational Research Building, University of Florida College of Medicine, 2004 Mowry Road, Gainesville, FL 32608","EMAIL":"ocarney1@ufl.edu","PHONE":"352-294-8361","NUM_GROUPS":"3","TOTAL_SUBJECTS":"12","STUDY_COMMENTS":"12 samples (4 mothers with 3 human milk fractions: fat, skim and whole)"}, "SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","GENDER":"Female"}, "SUBJECT_SAMPLE_FACTORS":[ { "Subject ID":"BLS001A_fat", "Sample ID":"BLS001A", "Factors":{"Milk fraction":"fat"} }, { "Subject ID":"BLS001A_skim", "Sample ID":"BLS001A_2", "Factors":{"Milk fraction":"skim"} }, { "Subject ID":"BLS001A_whole", "Sample ID":"BLS001A_3", "Factors":{"Milk fraction":"whole"} }, { "Subject ID":"BLS002A_fat", "Sample ID":"BLS002A", "Factors":{"Milk fraction":"fat"} }, { "Subject ID":"BLS002A_2_skim", "Sample ID":"BLS002A_2", "Factors":{"Milk fraction":"skim"} }, { "Subject ID":"BLS002A_3_whole", "Sample ID":"BLS002A_3", "Factors":{"Milk fraction":"whole"} }, { "Subject ID":"BLS003A_fat", "Sample ID":"BLS003A", "Factors":{"Milk fraction":"fat"} }, { "Subject ID":"BLS003A_2_skim", "Sample ID":"BLS003A_2", "Factors":{"Milk fraction":"skim"} }, { "Subject ID":"BLS003A_3_whole", "Sample ID":"BLS003A_3", "Factors":{"Milk fraction":"whole"} }, { "Subject ID":"BLS010A_fat", "Sample ID":"BLS010A", "Factors":{"Milk fraction":"fat"} }, { "Subject ID":"BLS010A_2_skim", "Sample ID":"BLS010A_2", "Factors":{"Milk fraction":"skim"} }, { "Subject ID":"BLS010A_3_whole", "Sample ID":"BLS010A_3", "Factors":{"Milk fraction":"whole"} } ], "COLLECTION":{"COLLECTION_SUMMARY":"mothers will arrive in a fasted state in the morning and complete an infant feeding questionnaire as described previously (Lemas et al. 2016). Mothers will then pump ~30mL human milk (HM) into polypropylene vials and stored at -80ÂșC.","SAMPLE_TYPE":"new"}, "TREATMENT":{"TREATMENT_SUMMARY":"human milk samples were fractionated (fat and skim) using centrifugation and whole milk samples wer snap frozen at -80c."}, "SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"None","SAMPLEPREP_PROTOCOL_FILENAME":"GMetabolomics_LCMS_Protocol_092117.pdf;Appendix_A_Internal_Standard_Prep_GLCMS.pdf"}, "CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Thermo Dionex Ultimate 3000","COLUMN_NAME":"ACE Excel 2 C18-PFP (100 x 2.1mm, 2um)","FLOW_RATE":"350 ul/min","SOLVENT_A":"0.1% Formic Acid in Water","SOLVENT_B":"Acetonitrile"}, "ANALYSIS":{"ANALYSIS_TYPE":"MS"}, "MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"NEGATIVE","MS_RESULTS_FILE":"ST000957_AN001571_Results.txt UNITS:peak height"}, "MS_METABOLITE_DATA":{ "Units":"peak height", 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