{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001136","ANALYSIS_ID":"AN001863","VERSION":"1","CREATED_ON":"February 13, 2019, 5:54 pm"},

"PROJECT":{"PROJECT_TITLE":"Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler","PROJECT_SUMMARY":"Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique pharmacokinetic characteristics. OPC-163493 shows a good bioavailability upon oral administration and primarily distributed to specific organs: the liver and kidneys, avoiding systemic toxicities. It exhibitsinsulin-independent antidiabetic effects in multiple animal models of type I and type II diabetes and antisteatotic effects in fatty liver models. These beneficial effects can be explained by the improvement of glucose metabolism and enhancement of energy expenditure by OPC-163493 in the liver. Moreover, OPC-163493 treatment lowered blood pressure, extended survival, and improved renal function in the rat model of stroke/hypertension, possibly by enhancing NO bioavailability in blood vessels and reducing mitochondrial ROS production. OPC-163493 is a liver-localized/targeted mUncoupler that ameliorates various complications of diabetes.","INSTITUTE":"Otsuka Pharmaceuticals","LAST_NAME":"Kanemoto","FIRST_NAME":"Naohide","ADDRESS":"463-10 Kagasuno Kawauchi-cho Tokushima 771-0192, Japan","EMAIL":"Kanemoto.Naohide@otsuka.jp","PHONE":"81-03-6717-1400"},

"STUDY":{"STUDY_TITLE":"Metabolme analysis of OPC-163493 on the Liver of ZDF rats (part-II)","STUDY_TYPE":"Long-term in vivo test","STUDY_SUMMARY":"Metabolome analysis were on the 24 samples of ZDF rats that were treated with OPC-163493 for 6-weeks. The 24 samples were composed of 3 different groups (Vehicles, OPC-163493 treatment, and baseline control; each n=8).","INSTITUTE":"Otsuka Pharmaceuticals","LAST_NAME":"Kanemoto","FIRST_NAME":"Naohide","ADDRESS":"463-10 Kagasuno Kawauchi-cho Tokushima 771-0192, Japan","EMAIL":"Kanemoto.Naohide@otsuka.jp","PHONE":"81-03-6717-1400"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Rattus norvegicus","TAXONOMY_ID":"10116","GENOTYPE_STRAIN":"ZDF rats","GENDER":"Not applicable"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Vehicle-1",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"-","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"Vehicle-2",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"-","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"Vehicle-3",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"-","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"Vehicle-4",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"-","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"Vehicle-5",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"-","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"Vehicle-6",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"-","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"Vehicle-7",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"-","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"Vehicle-8",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"-","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"OPC-9",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"6","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"OPC-10",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"6","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"OPC-11",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"6","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"OPC-12",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"6","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"OPC-13",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"6","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"OPC-14",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"6","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"OPC-15",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"6","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"OPC-16",
"Factors":{"Genotype":"17-week-old ZDF rat","Treatment":"6","Duration (weeks)":"6"}
},
{
"Subject ID":"-",
"Sample ID":"Baseline control-101",
"Factors":{"Genotype":"11-week-old ZDF rat","Treatment":"-","Duration (weeks)":"-"}
},
{
"Subject ID":"-",
"Sample ID":"Baseline control-102",
"Factors":{"Genotype":"11-week-old ZDF rat","Treatment":"-","Duration (weeks)":"-"}
},
{
"Subject ID":"-",
"Sample ID":"Baseline control-103",
"Factors":{"Genotype":"11-week-old ZDF rat","Treatment":"-","Duration (weeks)":"-"}
},
{
"Subject ID":"-",
"Sample ID":"Baseline control-104",
"Factors":{"Genotype":"11-week-old ZDF rat","Treatment":"-","Duration (weeks)":"-"}
},
{
"Subject ID":"-",
"Sample ID":"Baseline control-105",
"Factors":{"Genotype":"11-week-old ZDF rat","Treatment":"-","Duration (weeks)":"-"}
},
{
"Subject ID":"-",
"Sample ID":"Baseline control-106",
"Factors":{"Genotype":"11-week-old ZDF rat","Treatment":"-","Duration (weeks)":"-"}
},
{
"Subject ID":"-",
"Sample ID":"Baseline control-107",
"Factors":{"Genotype":"11-week-old ZDF rat","Treatment":"-","Duration (weeks)":"-"}
},
{
"Subject ID":"-",
"Sample ID":"Baseline control-108",
"Factors":{"Genotype":"11-week-old ZDF rat","Treatment":"-","Duration (weeks)":"-"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"After euthanasia by exsanguination under isoflurane anesthesia, a piece of liver was taken from the left lateral lobe on the treated rats, weighed at approximately 50mg, and immediately frozen in liquid nitrogen.","SAMPLE_TYPE":"Liver","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"The baseline control, the liver samples of ZDF rats were taken from the baseline control group of 11-week-old ZDF rats. And at the same time, the other 2 comparing groups were started on oral administration of OPC-163493 or vehicle solution for 6-weeks. After 6-week dosing, liver samples were taken from both groups, and the liver metabolites of all three groups including the baseline controls were analyzed.","TREATMENT_DOSE":"0mg/kg/day, 6mg/kg/day"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"The frozen liver samples were plunged into 50% acetonitrile/Milli-Q water containing internal standard. The sample was homogenized and then centrifuged. Subsequently, 800 uL of upper aqueous layer was filtered through a 5-kDa cutoff filter. The filtrate was centrifugally concentrated and re-suspended in 50 uL of Milli-Q water.","PROCESSING_STORAGE_CONDITIONS":"4℃","EXTRACT_STORAGE":"-80℃","SAMPLE_RESUSPENSION":"50 uL Mili-Q"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"capillary electrophoresis was connected with time-of-flight mass spectrometry (CE-TOFMS) for cation analysis and tandem mass spectrometry (CE-MS/MS) for anion.","CHROMATOGRAPHY_TYPE":"CE","INSTRUMENT_NAME":"Agilent 7100 CE","COLUMN_NAME":"Fused silica capillary, i.d. 50 µm × 80 cm"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 6460 QQQ","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"UNSPECIFIED","MS_COMMENTS":"The spectrometer was scanned from m/z 50 to 1,000. Peaks were extracted using MasterHands, automatic integration software (Keio University, Tsuruoka, Yamagata, Japan) and MassHunter Quantitative Analysis B.04.00 (Agilent Technologies) in order to obtain peak information including m/z, peak area, and migration time (MT). Signal peaks were annotated according to the HMT metabolite database based on their m/z values with the MTs. The peak area of each metabolite was normalized with respect to the area of the internal standard and metabolite concentration was evaluated by standard curves with three-point calibrations using each standard compound."},

"MS_METABOLITE_DATA":{
"Units":"Concentration (nmol/g tissue)",

"Data":[{"Metabolite":"Adenine","Vehicle-1":"10.59","Vehicle-2":"6.89","Vehicle-3":"4.77","Vehicle-4":"6.10","Vehicle-5":"8.33","Vehicle-6":"6.35","Vehicle-7":"7.08","Vehicle-8":"6.13","OPC-9":"7.39","OPC-10":"5.51","OPC-11":"8.05","OPC-12":"6.16","OPC-13":"5.24","OPC-14":"7.23","OPC-15":"4.05","OPC-16":"6.34","Baseline control-101":"6.70","Baseline control-102":"8.44","Baseline control-103":"5.77","Baseline control-104":"6.88","Baseline control-105":"5.69","Baseline control-106":"6.63","Baseline control-107":"5.34","Baseline control-108":"9.07"},{"Metabolite":"Adenosine","Vehicle-1":"128.8","Vehicle-2":"200.0","Vehicle-3":"97.2","Vehicle-4":"176.7","Vehicle-5":"216.2","Vehicle-6":"183.4","Vehicle-7":"172.9","Vehicle-8":"300.9","OPC-9":"125.4","OPC-10":"212.3","OPC-11":"212.1","OPC-12":"282.5","OPC-13":"256.6","OPC-14":"208.9","OPC-15":"65.6","OPC-16":"262.6","Baseline control-101":"390.3","Baseline control-102":"319.5","Baseline control-103":"368.5","Baseline control-104":"344.3","Baseline control-105":"267.9","Baseline control-106":"414.2","Baseline control-107":"291.1","Baseline control-108":"400.8"},{"Metabolite":"Alanine","Vehicle-1":"3319","Vehicle-2":"3534","Vehicle-3":"2542","Vehicle-4":"2450","Vehicle-5":"2459","Vehicle-6":"3303","Vehicle-7":"4290","Vehicle-8":"2377","OPC-9":"4346","OPC-10":"2707","OPC-11":"2482","OPC-12":"2896","OPC-13":"3146","OPC-14":"2880","OPC-15":"3115","OPC-16":"2908","Baseline control-101":"3205","Baseline control-102":"3915","Baseline control-103":"3133","Baseline control-104":"3257","Baseline control-105":"2849","Baseline control-106":"2394","Baseline control-107":"2863","Baseline control-108":"2937"},{"Metabolite":"Arginine","Vehicle-1":"1.69","Vehicle-2":"1.76","Vehicle-3":"1.80","Vehicle-4":"2.27","Vehicle-5":"1.95","Vehicle-6":"1.87","Vehicle-7":"1.64","Vehicle-8":"1.83","OPC-9":"1.94","OPC-10":"1.77","OPC-11":"1.80","OPC-12":"1.34","OPC-13":"1.51","OPC-14":"1.76","OPC-15":"1.87","OPC-16":"1.55","Baseline control-101":"1.69","Baseline control-102":"1.78","Baseline control-103":"1.96","Baseline control-104":"2.09","Baseline control-105":"2.09","Baseline control-106":"1.62","Baseline control-107":"1.70","Baseline control-108":"1.83"},{"Metabolite":"Argininosuccinic acid","Vehicle-1":"7.02","Vehicle-2":"12.79","Vehicle-3":"12.17","Vehicle-4":"16.51","Vehicle-5":"8.85","Vehicle-6":"12.38","Vehicle-7":"12.28","Vehicle-8":"14.31","OPC-9":"8.31","OPC-10":"13.87","OPC-11":"10.45","OPC-12":"10.58","OPC-13":"12.95","OPC-14":"13.66","OPC-15":"12.01","OPC-16":"10.26","Baseline control-101":"9.42","Baseline control-102":"8.20","Baseline control-103":"11.38","Baseline control-104":"10.53","Baseline control-105":"10.43","Baseline control-106":"10.34","Baseline control-107":"8.96","Baseline control-108":"11.84"},{"Metabolite":"Asparagine","Vehicle-1":"50.8","Vehicle-2":"53.7","Vehicle-3":"48.8","Vehicle-4":"53.5","Vehicle-5":"41.9","Vehicle-6":"53.6","Vehicle-7":"47.3","Vehicle-8":"47.1","OPC-9":"47.1","OPC-10":"52.3","OPC-11":"48.4","OPC-12":"42.7","OPC-13":"46.7","OPC-14":"48.3","OPC-15":"50.1","OPC-16":"43.6","Baseline control-101":"49.8","Baseline control-102":"57.5","Baseline control-103":"58.8","Baseline control-104":"63.0","Baseline control-105":"52.7","Baseline control-106":"50.4","Baseline control-107":"51.0","Baseline control-108":"56.6"},{"Metabolite":"Aspartic acid","Vehicle-1":"1223","Vehicle-2":"2061","Vehicle-3":"1162","Vehicle-4":"1559","Vehicle-5":"1070","Vehicle-6":"1891","Vehicle-7":"1704","Vehicle-8":"1517","OPC-9":"1167","OPC-10":"1488","OPC-11":"1320","OPC-12":"1313","OPC-13":"2211","OPC-14":"1767","OPC-15":"1604","OPC-16":"1649","Baseline control-101":"1132","Baseline control-102":"1220","Baseline control-103":"1694","Baseline control-104":"1374","Baseline control-105":"1586","Baseline control-106":"1094","Baseline control-107":"1160","Baseline control-108":"1256"},{"Metabolite":"Beta-Alanine","Vehicle-1":"52","Vehicle-2":"51","Vehicle-3":"38","Vehicle-4":"54","Vehicle-5":"37","Vehicle-6":"52","Vehicle-7":"49","Vehicle-8":"51","OPC-9":"44","OPC-10":"39","OPC-11":"48","OPC-12":"38","OPC-13":"43","OPC-14":"49","OPC-15":"47","OPC-16":"39","Baseline control-101":"47","Baseline control-102":"51","Baseline control-103":"51","Baseline control-104":"63","Baseline control-105":"46","Baseline control-106":"40","Baseline control-107":"44","Baseline control-108":"49"},{"Metabolite":"Betaine","Vehicle-1":"1444","Vehicle-2":"1021","Vehicle-3":"1923","Vehicle-4":"1598","Vehicle-5":"2798","Vehicle-6":"993","Vehicle-7":"1055","Vehicle-8":"2021","OPC-9":"1126","OPC-10":"932","OPC-11":"1249","OPC-12":"1198","OPC-13":"1049","OPC-14":"2065","OPC-15":"1328","OPC-16":"899","Baseline control-101":"1112","Baseline control-102":"574","Baseline control-103":"1041","Baseline control-104":"1286","Baseline control-105":"585","Baseline control-106":"982","Baseline control-107":"789","Baseline control-108":"1069"},{"Metabolite":"Betaine aldehyde","Vehicle-1":"7.20","Vehicle-2":"11.99","Vehicle-3":"12.61","Vehicle-4":"15.07","Vehicle-5":"10.25","Vehicle-6":"8.47","Vehicle-7":"10.23","Vehicle-8":"15.08","OPC-9":"7.31","OPC-10":"10.68","OPC-11":"9.55","OPC-12":"10.99","OPC-13":"14.45","OPC-14":"15.51","OPC-15":"13.35","OPC-16":"13.20","Baseline control-101":"8.55","Baseline control-102":"7.00","Baseline control-103":"9.60","Baseline control-104":"10.86","Baseline control-105":"9.87","Baseline control-106":"11.30","Baseline control-107":"9.60","Baseline control-108":"13.38"},{"Metabolite":"Carnitine","Vehicle-1":"336","Vehicle-2":"341","Vehicle-3":"342","Vehicle-4":"295","Vehicle-5":"286","Vehicle-6":"317","Vehicle-7":"320","Vehicle-8":"322","OPC-9":"358","OPC-10":"298","OPC-11":"308","OPC-12":"366","OPC-13":"297","OPC-14":"310","OPC-15":"363","OPC-16":"283","Baseline control-101":"211","Baseline control-102":"282","Baseline control-103":"230","Baseline control-104":"233","Baseline control-105":"267","Baseline control-106":"218","Baseline control-107":"202","Baseline control-108":"220"},{"Metabolite":"Choline","Vehicle-1":"70.3","Vehicle-2":"109.2","Vehicle-3":"91.8","Vehicle-4":"153.5","Vehicle-5":"80.7","Vehicle-6":"51.9","Vehicle-7":"71.9","Vehicle-8":"122.0","OPC-9":"53.9","OPC-10":"76.9","OPC-11":"93.7","OPC-12":"73.0","OPC-13":"116.2","OPC-14":"125.7","OPC-15":"101.3","OPC-16":"92.8","Baseline control-101":"57.4","Baseline control-102":"49.0","Baseline control-103":"94.4","Baseline control-104":"100.3","Baseline control-105":"80.8","Baseline control-106":"68.0","Baseline control-107":"84.0","Baseline control-108":"112.0"},{"Metabolite":"cis-3-hydroxyproline","Vehicle-1":"11.3","Vehicle-2":"12.2","Vehicle-3":"11.9","Vehicle-4":"12.2","Vehicle-5":"11.5","Vehicle-6":"12.3","Vehicle-7":"12.6","Vehicle-8":"12.8","OPC-9":"11.0","OPC-10":"11.6","OPC-11":"12.1","OPC-12":"10.7","OPC-13":"11.2","OPC-14":"11.9","OPC-15":"12.2","OPC-16":"10.6","Baseline control-101":"18.6","Baseline control-102":"18.9","Baseline control-103":"19.0","Baseline control-104":"18.4","Baseline control-105":"17.2","Baseline control-106":"14.6","Baseline control-107":"15.9","Baseline control-108":"15.8"},{"Metabolite":"Citrulline","Vehicle-1":"7.42","Vehicle-2":"13.10","Vehicle-3":"13.00","Vehicle-4":"19.62","Vehicle-5":"9.58","Vehicle-6":"14.16","Vehicle-7":"12.99","Vehicle-8":"13.82","OPC-9":"9.03","OPC-10":"15.21","OPC-11":"11.94","OPC-12":"10.13","OPC-13":"9.69","OPC-14":"14.48","OPC-15":"10.84","OPC-16":"9.25","Baseline control-101":"11.98","Baseline control-102":"11.73","Baseline control-103":"13.99","Baseline control-104":"13.79","Baseline control-105":"12.74","Baseline control-106":"12.67","Baseline control-107":"10.28","Baseline control-108":"14.56"},{"Metabolite":"Creatine","Vehicle-1":"542","Vehicle-2":"720","Vehicle-3":"791","Vehicle-4":"846","Vehicle-5":"559","Vehicle-6":"793","Vehicle-7":"728","Vehicle-8":"692","OPC-9":"722","OPC-10":"724","OPC-11":"757","OPC-12":"619","OPC-13":"570","OPC-14":"569","OPC-15":"689","OPC-16":"607","Baseline control-101":"883","Baseline control-102":"757","Baseline control-103":"596","Baseline control-104":"567","Baseline control-105":"778","Baseline control-106":"834","Baseline control-107":"655","Baseline control-108":"709"},{"Metabolite":"Creatinine","Vehicle-1":"10.8","Vehicle-2":"13.1","Vehicle-3":"12.9","Vehicle-4":"11.9","Vehicle-5":"11.8","Vehicle-6":"11.6","Vehicle-7":"11.2","Vehicle-8":"14.1","OPC-9":"11.7","OPC-10":"12.9","OPC-11":"12.4","OPC-12":"12.0","OPC-13":"12.0","OPC-14":"15.3","OPC-15":"11.7","OPC-16":"12.8","Baseline control-101":"12.6","Baseline control-102":"13.2","Baseline control-103":"12.1","Baseline control-104":"12.9","Baseline control-105":"11.9","Baseline control-106":"10.9","Baseline control-107":"9.7","Baseline control-108":"11.5"},{"Metabolite":"Cystathionine","Vehicle-1":"4.47","Vehicle-2":"5.47","Vehicle-3":"4.72","Vehicle-4":"4.73","Vehicle-5":"4.37","Vehicle-6":"4.56","Vehicle-7":"4.72","Vehicle-8":"4.47","OPC-9":"5.84","OPC-10":"4.28","OPC-11":"4.13","OPC-12":"4.18","OPC-13":"4.09","OPC-14":"4.05","OPC-15":"5.16","OPC-16":"3.89","Baseline control-101":"4.95","Baseline control-102":"5.19","Baseline control-103":"5.50","Baseline control-104":"5.11","Baseline control-105":"6.24","Baseline control-106":"4.84","Baseline control-107":"5.67","Baseline control-108":"5.90"},{"Metabolite":"Cysteine","Vehicle-1":"5.02","Vehicle-2":"6.85","Vehicle-3":"10.57","Vehicle-4":"12.35","Vehicle-5":"5.77","Vehicle-6":"8.92","Vehicle-7":"8.71","Vehicle-8":"5.39","OPC-9":"15.82","OPC-10":"19.77","OPC-11":"11.97","OPC-12":"8.14","OPC-13":"8.18","OPC-14":"7.65","OPC-15":"7.10","OPC-16":"12.13","Baseline control-101":"3.53","Baseline control-102":"6.73","Baseline control-103":"7.69","Baseline control-104":"6.91","Baseline control-105":"6.31","Baseline control-106":"5.32","Baseline control-107":"6.03","Baseline control-108":"5.23"},{"Metabolite":"Dimethylglycine","Vehicle-1":"24.9","Vehicle-2":"25.8","Vehicle-3":"33.7","Vehicle-4":"27.0","Vehicle-5":"32.9","Vehicle-6":"16.8","Vehicle-7":"19.0","Vehicle-8":"22.4","OPC-9":"21.9","OPC-10":"15.4","OPC-11":"16.3","OPC-12":"20.3","OPC-13":"18.0","OPC-14":"21.0","OPC-15":"28.2","OPC-16":"12.0","Baseline control-101":"22.9","Baseline control-102":"18.3","Baseline control-103":"19.3","Baseline control-104":"22.4","Baseline control-105":"18.1","Baseline control-106":"22.5","Baseline control-107":"20.9","Baseline control-108":"27.8"},{"Metabolite":"Gamma-Aminobutyric acid","Vehicle-1":"15.11","Vehicle-2":"15.69","Vehicle-3":"14.75","Vehicle-4":"10.51","Vehicle-5":"11.35","Vehicle-6":"12.35","Vehicle-7":"13.25","Vehicle-8":"10.29","OPC-9":"19.49","OPC-10":"15.61","OPC-11":"14.17","OPC-12":"11.50","OPC-13":"11.18","OPC-14":"12.84","OPC-15":"13.28","OPC-16":"10.33","Baseline control-101":"12.56","Baseline control-102":"17.89","Baseline control-103":"12.83","Baseline control-104":"21.57","Baseline control-105":"10.61","Baseline control-106":"10.46","Baseline control-107":"9.88","Baseline control-108":"9.31"},{"Metabolite":"Glutamic acid","Vehicle-1":"5188","Vehicle-2":"4420","Vehicle-3":"3555","Vehicle-4":"3038","Vehicle-5":"2382","Vehicle-6":"4264","Vehicle-7":"3687","Vehicle-8":"3814","OPC-9":"5035","OPC-10":"5341","OPC-11":"4412","OPC-12":"5710","OPC-13":"3635","OPC-14":"3425","OPC-15":"3547","OPC-16":"4931","Baseline control-101":"4755","Baseline control-102":"5105","Baseline control-103":"4049","Baseline control-104":"4279","Baseline control-105":"4985","Baseline control-106":"4485","Baseline control-107":"5314","Baseline control-108":"4274"},{"Metabolite":"Glutamine","Vehicle-1":"5535","Vehicle-2":"6039","Vehicle-3":"5074","Vehicle-4":"5450","Vehicle-5":"5132","Vehicle-6":"6064","Vehicle-7":"7158","Vehicle-8":"5873","OPC-9":"6550","OPC-10":"5490","OPC-11":"6492","OPC-12":"5761","OPC-13":"6303","OPC-14":"6577","OPC-15":"6469","OPC-16":"6331","Baseline control-101":"4908","Baseline control-102":"4584","Baseline control-103":"6249","Baseline control-104":"6418","Baseline control-105":"5984","Baseline control-106":"5688","Baseline control-107":"5605","Baseline control-108":"4784"},{"Metabolite":"Glutathione","Vehicle-1":"2862","Vehicle-2":"4936","Vehicle-3":"4857","Vehicle-4":"4533","Vehicle-5":"3834","Vehicle-6":"5009","Vehicle-7":"5063","Vehicle-8":"4538","OPC-9":"5892","OPC-10":"5129","OPC-11":"4857","OPC-12":"4971","OPC-13":"4635","OPC-14":"4577","OPC-15":"5000","OPC-16":"5258","Baseline control-101":"4732","Baseline control-102":"4720","Baseline control-103":"4810","Baseline control-104":"4917","Baseline control-105":"5019","Baseline control-106":"5102","Baseline control-107":"5153","Baseline control-108":"4654"},{"Metabolite":"Glycine","Vehicle-1":"1387","Vehicle-2":"1550","Vehicle-3":"1572","Vehicle-4":"1939","Vehicle-5":"1538","Vehicle-6":"1628","Vehicle-7":"1751","Vehicle-8":"1725","OPC-9":"1644","OPC-10":"1511","OPC-11":"1535","OPC-12":"1296","OPC-13":"1730","OPC-14":"1808","OPC-15":"1681","OPC-16":"1402","Baseline control-101":"1592","Baseline control-102":"1514","Baseline control-103":"1769","Baseline control-104":"1533","Baseline control-105":"1407","Baseline control-106":"1732","Baseline control-107":"1280","Baseline 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}

}