{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001260","ANALYSIS_ID":"AN002090","VERSION":"1","CREATED_ON":"October 2, 2019, 9:13 am"},

"PROJECT":{"PROJECT_TITLE":"Fusobacterium nucleatum metabolome","PROJECT_SUMMARY":"CE-TOFMS-based untargeted analysis of the intracellular metabolite changes of F. nucleatum when co-cultured with other oral microbes","INSTITUTE":"Osaka University Graduate School of Dentistry","DEPARTMENT":"Department of Preventive Dentistry","LAST_NAME":"Kuboniwa","FIRST_NAME":"Masae","ADDRESS":"Yamadaoka 1-8","EMAIL":"kuboniwa@dent.osaka-u.ac.jp","PHONE":"81668792922"},

"STUDY":{"STUDY_TITLE":"Metabolic changes of Fusobacterium nucleatum when co-cultured with other oral microbes (part-I)","STUDY_SUMMARY":"We used membrane-separated co-culture systems to globally assess metabolomic changes of Fusobacterium nucleatum when co-cultured with Streptococcus gordonii and/or Veillonella parvula.","INSTITUTE":"Osaka University Graduate School of Dentistry","DEPARTMENT":"Department of Preventive Dentistry","LAST_NAME":"Kuboniwa","FIRST_NAME":"Masae","ADDRESS":"Yamadaoka 1-8","EMAIL":"kuboniwa@dent.osaka-u.ac.jp","PHONE":"81668792922"},

"SUBJECT":{"SUBJECT_TYPE":"Bacteria","SUBJECT_SPECIES":"Fusobacterium nucleatum subsp. nucleatum ATCC 25586","TAXONOMY_ID":"190304"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Fn_1",
"Factors":{"partner":"none"}
},
{
"Subject ID":"-",
"Sample ID":"Fn_2",
"Factors":{"partner":"none"}
},
{
"Subject ID":"-",
"Sample ID":"Fn_3",
"Factors":{"partner":"none"}
},
{
"Subject ID":"-",
"Sample ID":"Fn-Sg_1",
"Factors":{"partner":"Sg"}
},
{
"Subject ID":"-",
"Sample ID":"Fn-Sg_2",
"Factors":{"partner":"Sg"}
},
{
"Subject ID":"-",
"Sample ID":"Fn-Sg_3",
"Factors":{"partner":"Sg"}
},
{
"Subject ID":"-",
"Sample ID":"Fn-Vp_1",
"Factors":{"partner":"Vp"}
},
{
"Subject ID":"-",
"Sample ID":"Fn-Vp_2",
"Factors":{"partner":"Vp"}
},
{
"Subject ID":"-",
"Sample ID":"Fn-Vp_3",
"Factors":{"partner":"Vp"}
},
{
"Subject ID":"-",
"Sample ID":"Fn-SgVp_1",
"Factors":{"partner":"SgVp"}
},
{
"Subject ID":"-",
"Sample ID":"Fn-SgVp_2",
"Factors":{"partner":"SgVp"}
},
{
"Subject ID":"-",
"Sample ID":"Fn-SgVp_3",
"Factors":{"partner":"SgVp"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"After 6 h of co-culture, F. nucleatum cells were collected by pipetting from the lower chamber and washed with Milli-Q water by centrifugation. Bacterial pellets were immediately fixed by adding methanol containing 5 µM internal standard.","SAMPLE_TYPE":"Bacterial cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"Co-culture growth was performed by inoculating 1.4E+10 cells of F. nucleatum in CDM in the lower chamber of a Transwell unit with 0.4-µm pore polystyrene membrane inserts (Corning, NY, USA), into which 1.4E+10 cells of S. gordonii, V. parvula or their mixture (7E+9 cells each) in CDM, or an equal volume of CDM (as a control) were added. The setup was anaerobically incubated in triplicate for 37°C."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"To remove protein, 2 ml of chloroform and 0.8 ml of ultrapure water were added to the samples, which were thoroughly mixed and centrifuged at 2300 × g for 5 minutes at 4˚C. The upper aqueous layer was then transferred to ultrafilter tips (Amicon ultrafilter system™) and centrifuged at 9100 × g for 120 minutes at 4˚C. Filtered material was dried under reduced pressure, followed by suspension in 50 µl of ultrapure water."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"CE","INSTRUMENT_NAME":"Agilent 6210","COLUMN_NAME":"None"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 6210 TOF","INSTRUMENT_TYPE":"CE-TOF","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"The conditions for measurement of cationic metabolites were as follows. Run buffer: Cation Buffer Solution (H3301-1001; Human Metabolome Technologies (HMT)), CE voltage: +27kV, MS ionization: ESI positive, MS capillary voltage: 4,000V, MS scan range: m/z 50-1,000, and sheath liquid: HMT Sheath Liquid (H3301-1020). Identification of metabolites and evaluation of the relative amounts were conducted using Master Hands (version 2.16.0.15 and 2.17.1.11; Keio University, Tokyo, Japan) with the HMT metabolite database. The relative amount of each metabolite was calculated with reference to the internal standard material (HMT)."},

"MS_METABOLITE_DATA":{
"Units":"AU",

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