{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001681","ANALYSIS_ID":"AN002744","VERSION":"1","CREATED_ON":"February 4, 2021, 11:40 am"},

"PROJECT":{"PROJECT_TITLE":"Untargeted plasma metabolomics to predict the time to spontaneous onset of labor","PROJECT_SUMMARY":"Longitudinal blood collection during the last 100 days of pregnancy and untargeted LC-MS metabolomics to predict the time to spontaneous onset of labor","INSTITUTE":"Stanford University","DEPARTMENT":"Genetics","LAST_NAME":"Contrepois","FIRST_NAME":"Kevin","ADDRESS":"1291 Welch rd, Biomedical innovations building-Room 4400, STANFORD, California, 94305, USA","EMAIL":"kcontrep@stanford.edu","PHONE":"6507239914"},

"STUDY":{"STUDY_TITLE":"Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset","STUDY_SUMMARY":"Estimating the time of delivery is of high clinical importance as pre- and post-term deviations are associated with complications for the mother and her offspring. However, current estimation approaches are inaccurate. As pregnancy progresses towards labor, major transitions occur in fetomaternal immune, metabolic, and endocrine systems that culminate in the delivery of the fetus. The comprehensive characterization of metabolic, proteomic and immune cell events that precede the spontaneous onset of labor is a key step to understanding these physiological transitions and identifying predictive biomarkers of parturition. Here, over 7,000 circulating plasma analytes and peripheral immune cell responses collected during the last 100 days of pregnancy were integrated into a multi-omic model that accurately predicted the time to spontaneous onset of labor (R = 0.85, p-value = 1.2e-40, training set; R = 0.81, p-value = 3.9e-7, independent test set). Coordinated fluctuations marked a molecular shift from pregnancy progression to pre-labor onset biology 2–4 weeks before delivery. Our study lays the groundwork for developing blood-based methods for predicting the onset of labor, anchored in mechanisms shared in preterm, term, and postterm pregnancies.","INSTITUTE":"Stanford University","LAST_NAME":"Contrepois","FIRST_NAME":"Kevin","ADDRESS":"1291 Welch rd, Biomedical innovations building-Room 4400, STANFORD, California, 94305, USA","EMAIL":"kcontrep@stanford.edu","PHONE":"6506664538"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","GENDER":"Female"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"1",
"Sample ID":"001_26_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"26.4","DOL":"-101","RAW_FILE_NAME":"pHILIC_001_26_A;nHILIC_001_26_A;pRPLC_001_26_A;nRPLC_001_26_A"}
},
{
"Subject ID":"1",
"Sample ID":"001_33_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"33.6","DOL":"-51","RAW_FILE_NAME":"pHILIC_001_33_B;nHILIC_001_33_B;pRPLC_001_33_B;nRPLC_001_33_B"}
},
{
"Subject ID":"1",
"Sample ID":"001_35_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"35.6","DOL":"-37","RAW_FILE_NAME":"pHILIC_001_35_C;nHILIC_001_35_C;pRPLC_001_35_C;nRPLC_001_35_C"}
},
{
"Subject ID":"3",
"Sample ID":"003_25_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"25.3","DOL":"-61","RAW_FILE_NAME":"pHILIC_003_25_A;nHILIC_003_25_A;pRPLC_003_25_A;nRPLC_003_25_A"}
},
{
"Subject ID":"3",
"Sample ID":"003_30_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"30.7","DOL":"-28","RAW_FILE_NAME":"pHILIC_003_30_B;nHILIC_003_30_B;pRPLC_003_30_B;nRPLC_003_30_B"}
},
{
"Subject ID":"3",
"Sample ID":"003_32_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"33.6","DOL":"-8","RAW_FILE_NAME":"pHILIC_003_32_C;nHILIC_003_32_C;pRPLC_003_32_C;nRPLC_003_32_C"}
},
{
"Subject ID":"5",
"Sample ID":"005_25_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"25.3","DOL":"-63","RAW_FILE_NAME":"pHILIC_005_25_A;nHILIC_005_25_A;pRPLC_005_25_A;nRPLC_005_25_A"}
},
{
"Subject ID":"5",
"Sample ID":"005_29_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"29.3","DOL":"-35","RAW_FILE_NAME":"pHILIC_005_29_B;nHILIC_005_29_B;pRPLC_005_29_B;nRPLC_005_29_B"}
},
{
"Subject ID":"5",
"Sample ID":"005_32_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"32.3","DOL":"-14","RAW_FILE_NAME":"pHILIC_005_32_C;nHILIC_005_32_C;pRPLC_005_32_C;nRPLC_005_32_C"}
},
{
"Subject ID":"6",
"Sample ID":"006_25_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"25","DOL":"-99","RAW_FILE_NAME":"pHILIC_006_25_A;nHILIC_006_25_A;pRPLC_006_25_A;nRPLC_006_25_A"}
},
{
"Subject ID":"6",
"Sample ID":"006_30_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"30.6","DOL":"-60","RAW_FILE_NAME":"pHILIC_006_30_B;nHILIC_006_30_B;pRPLC_006_30_B;nRPLC_006_30_B"}
},
{
"Subject ID":"6",
"Sample ID":"006_34_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"34.6","DOL":"-32","RAW_FILE_NAME":"pHILIC_006_34_C;nHILIC_006_34_C;pRPLC_006_34_C;nRPLC_006_34_C"}
},
{
"Subject ID":"7",
"Sample ID":"007_28_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"28.3","DOL":"-73","RAW_FILE_NAME":"pHILIC_007_28_A;nHILIC_007_28_A;pRPLC_007_28_A;nRPLC_007_28_A"}
},
{
"Subject ID":"7",
"Sample ID":"007_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"36.1","DOL":"-18","RAW_FILE_NAME":"pHILIC_007_36_B;nHILIC_007_36_B;pRPLC_007_36_B;nRPLC_007_36_B"}
},
{
"Subject ID":"8",
"Sample ID":"008_28_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"28.1","DOL":"-48","RAW_FILE_NAME":"pHILIC_008_28_A;nHILIC_008_28_A;pRPLC_008_28_A;nRPLC_008_28_A"}
},
{
"Subject ID":"8",
"Sample ID":"008_32_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"32.1","DOL":"-20","RAW_FILE_NAME":"pHILIC_008_32_B;nHILIC_008_32_B;pRPLC_008_32_B;nRPLC_008_32_B"}
},
{
"Subject ID":"8",
"Sample ID":"008_33_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"33.1","DOL":"-9","RAW_FILE_NAME":"pHILIC_008_33_C;nHILIC_008_33_C;pRPLC_008_33_C;nRPLC_008_33_C"}
},
{
"Subject ID":"12",
"Sample ID":"012_25_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"25.4","DOL":"-98","RAW_FILE_NAME":"pHILIC_012_25_A;nHILIC_012_25_A;pRPLC_012_25_A;nRPLC_012_25_A"}
},
{
"Subject ID":"12",
"Sample ID":"012_29_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"29.4","DOL":"-70","RAW_FILE_NAME":"pHILIC_012_29_B;nHILIC_012_29_B;pRPLC_012_29_B;nRPLC_012_29_B"}
},
{
"Subject ID":"12",
"Sample ID":"012_34_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"34.3","DOL":"-36","RAW_FILE_NAME":"pHILIC_012_34_C;nHILIC_012_34_C;pRPLC_012_34_C;nRPLC_012_34_C"}
},
{
"Subject ID":"14",
"Sample ID":"014_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"26.7","DOL":"-94","RAW_FILE_NAME":"pHILIC_014_27_A;nHILIC_014_27_A;pRPLC_014_27_A;nRPLC_014_27_A"}
},
{
"Subject ID":"14",
"Sample ID":"014_30_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"30.9","DOL":"-65","RAW_FILE_NAME":"pHILIC_014_30_B;nHILIC_014_30_B;pRPLC_014_30_B;nRPLC_014_30_B"}
},
{
"Subject ID":"14",
"Sample ID":"014_35_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"35.3","DOL":"-34","RAW_FILE_NAME":"pHILIC_014_35_C;nHILIC_014_35_C;pRPLC_014_35_C;nRPLC_014_35_C"}
},
{
"Subject ID":"16",
"Sample ID":"016_32_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"32.9","DOL":"-51","RAW_FILE_NAME":"pHILIC_016_32_A;nHILIC_016_32_A;pRPLC_016_32_A;nRPLC_016_32_A"}
},
{
"Subject ID":"16",
"Sample ID":"016_34_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"34.4","DOL":"-37","RAW_FILE_NAME":"pHILIC_016_34_B;nHILIC_016_34_B;pRPLC_016_34_B;nRPLC_016_34_B"}
},
{
"Subject ID":"16",
"Sample ID":"016_37_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"36.7","DOL":"-19","RAW_FILE_NAME":"pHILIC_016_37_C;nHILIC_016_37_C;pRPLC_016_37_C;nRPLC_016_37_C"}
},
{
"Subject ID":"17",
"Sample ID":"017_31_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"31.7","DOL":"-16","RAW_FILE_NAME":"pHILIC_017_31_A;nHILIC_017_31_A;pRPLC_017_31_A;nRPLC_017_31_A"}
},
{
"Subject ID":"17",
"Sample ID":"017_33_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"33.6","DOL":"-3","RAW_FILE_NAME":"pHILIC_017_33_B;nHILIC_017_33_B;pRPLC_017_33_B;nRPLC_017_33_B"}
},
{
"Subject ID":"18",
"Sample ID":"018_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.7","DOL":"-82","RAW_FILE_NAME":"pHILIC_018_27_A;nHILIC_018_27_A;pRPLC_018_27_A;nRPLC_018_27_A"}
},
{
"Subject ID":"18",
"Sample ID":"018_31_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"31.7","DOL":"-54","RAW_FILE_NAME":"pHILIC_018_31_B;nHILIC_018_31_B;pRPLC_018_31_B;nRPLC_018_31_B"}
},
{
"Subject ID":"18",
"Sample ID":"018_35_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"35.7","DOL":"-26","RAW_FILE_NAME":"pHILIC_018_35_C;nHILIC_018_35_C;pRPLC_018_35_C;nRPLC_018_35_C"}
},
{
"Subject ID":"19",
"Sample ID":"019_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.9","DOL":"-89","RAW_FILE_NAME":"pHILIC_019_27_A;nHILIC_019_27_A;pRPLC_019_27_A;nRPLC_019_27_A"}
},
{
"Subject ID":"19",
"Sample ID":"019_31_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"31.9","DOL":"-61","RAW_FILE_NAME":"pHILIC_019_31_B;nHILIC_019_31_B;pRPLC_019_31_B;nRPLC_019_31_B"}
},
{
"Subject ID":"19",
"Sample ID":"019_36_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"36.4","DOL":"-29","RAW_FILE_NAME":"pHILIC_019_36_C;nHILIC_019_36_C;pRPLC_019_36_C;nRPLC_019_36_C"}
},
{
"Subject ID":"21",
"Sample ID":"021_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.4","DOL":"-86","RAW_FILE_NAME":"pHILIC_021_27_A;nHILIC_021_27_A;pRPLC_021_27_A;nRPLC_021_27_A"}
},
{
"Subject ID":"21",
"Sample ID":"021_34_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"34.3","DOL":"-38","RAW_FILE_NAME":"pHILIC_021_34_B;nHILIC_021_34_B;pRPLC_021_34_B;nRPLC_021_34_B"}
},
{
"Subject ID":"21",
"Sample ID":"021_36_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"36.4","DOL":"-23","RAW_FILE_NAME":"pHILIC_021_36_C;nHILIC_021_36_C;pRPLC_021_36_C;nRPLC_021_36_C"}
},
{
"Subject ID":"22",
"Sample ID":"022_26_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"26.3","DOL":"-95","RAW_FILE_NAME":"pHILIC_022_26_A;nHILIC_022_26_A;pRPLC_022_26_A;nRPLC_022_26_A"}
},
{
"Subject ID":"22",
"Sample ID":"022_31_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"31.3","DOL":"-60","RAW_FILE_NAME":"pHILIC_022_31_B;nHILIC_022_31_B;pRPLC_022_31_B;nRPLC_022_31_B"}
},
{
"Subject ID":"22",
"Sample ID":"022_34_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"34.9","DOL":"-35","RAW_FILE_NAME":"pHILIC_022_34_C;nHILIC_022_34_C;pRPLC_022_34_C;nRPLC_022_34_C"}
},
{
"Subject ID":"24",
"Sample ID":"024_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.1","DOL":"-71","RAW_FILE_NAME":"pHILIC_024_27_A;nHILIC_024_27_A;pRPLC_024_27_A;nRPLC_024_27_A"}
},
{
"Subject ID":"24",
"Sample ID":"024_29_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"29.1","DOL":"-57","RAW_FILE_NAME":"pHILIC_024_29_B;nHILIC_024_29_B;pRPLC_024_29_B;nRPLC_024_29_B"}
},
{
"Subject ID":"24",
"Sample ID":"024_34_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"34.1","DOL":"-23","RAW_FILE_NAME":"pHILIC_024_34_C;nHILIC_024_34_C;pRPLC_024_34_C;nRPLC_024_34_C"}
},
{
"Subject ID":"25",
"Sample ID":"025_26_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"26.9","DOL":"-85","RAW_FILE_NAME":"pHILIC_025_26_A;nHILIC_025_26_A;pRPLC_025_26_A;nRPLC_025_26_A"}
},
{
"Subject ID":"25",
"Sample ID":"025_30_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"30.9","DOL":"-57","RAW_FILE_NAME":"pHILIC_025_30_B;nHILIC_025_30_B;pRPLC_025_30_B;nRPLC_025_30_B"}
},
{
"Subject ID":"25",
"Sample ID":"025_32_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"33","DOL":"-43","RAW_FILE_NAME":"pHILIC_025_32_C;nHILIC_025_32_C;pRPLC_025_32_C;nRPLC_025_32_C"}
},
{
"Subject ID":"26",
"Sample ID":"026_31_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"31.4","DOL":"-66","RAW_FILE_NAME":"pHILIC_026_31_A;nHILIC_026_31_A;pRPLC_026_31_A;nRPLC_026_31_A"}
},
{
"Subject ID":"26",
"Sample ID":"026_34_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"34.3","DOL":"-46","RAW_FILE_NAME":"pHILIC_026_34_B;nHILIC_026_34_B;pRPLC_026_34_B;nRPLC_026_34_B"}
},
{
"Subject ID":"26",
"Sample ID":"026_37_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"37.4","DOL":"-24","RAW_FILE_NAME":"pHILIC_026_37_C;nHILIC_026_37_C;pRPLC_026_37_C;nRPLC_026_37_C"}
},
{
"Subject ID":"27",
"Sample ID":"027_24_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"24.4","DOL":"-75","RAW_FILE_NAME":"pHILIC_027_24_A;nHILIC_027_24_A;pRPLC_027_24_A;nRPLC_027_24_A"}
},
{
"Subject ID":"27",
"Sample ID":"027_28_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"28.3","DOL":"-48","RAW_FILE_NAME":"pHILIC_027_28_B;nHILIC_027_28_B;pRPLC_027_28_B;nRPLC_027_28_B"}
},
{
"Subject ID":"27",
"Sample ID":"027_32_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"32.1","DOL":"-21","RAW_FILE_NAME":"pHILIC_027_32_C;nHILIC_027_32_C;pRPLC_027_32_C;nRPLC_027_32_C"}
},
{
"Subject ID":"28",
"Sample ID":"028_31_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"31.4","DOL":"-53","RAW_FILE_NAME":"pHILIC_028_31_A;nHILIC_028_31_A;pRPLC_028_31_A;nRPLC_028_31_A"}
},
{
"Subject ID":"28",
"Sample ID":"028_34_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"34.1","DOL":"-34","RAW_FILE_NAME":"pHILIC_028_34_B;nHILIC_028_34_B;pRPLC_028_34_B;nRPLC_028_34_B"}
},
{
"Subject ID":"28",
"Sample ID":"028_36_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"36.1","DOL":"-20","RAW_FILE_NAME":"pHILIC_028_36_C;nHILIC_028_36_C;pRPLC_028_36_C;nRPLC_028_36_C"}
},
{
"Subject ID":"32",
"Sample ID":"032_24_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"24.9","DOL":"-102","RAW_FILE_NAME":"pHILIC_032_24_A;nHILIC_032_24_A;pRPLC_032_24_A;nRPLC_032_24_A"}
},
{
"Subject ID":"32",
"Sample ID":"032_27_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"27.9","DOL":"-81","RAW_FILE_NAME":"pHILIC_032_27_B;nHILIC_032_27_B;pRPLC_032_27_B;nRPLC_032_27_B"}
},
{
"Subject ID":"32",
"Sample ID":"032_37_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"37.3","DOL":"-15","RAW_FILE_NAME":"pHILIC_032_37_C;nHILIC_032_37_C;pRPLC_032_37_C;nRPLC_032_37_C"}
},
{
"Subject ID":"33",
"Sample ID":"033_31_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"31.7","DOL":"-37","RAW_FILE_NAME":"pHILIC_033_31_A;nHILIC_033_31_A;pRPLC_033_31_A;nRPLC_033_31_A"}
},
{
"Subject ID":"33",
"Sample ID":"033_33_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"33.7","DOL":"-23","RAW_FILE_NAME":"pHILIC_033_33_B;nHILIC_033_33_B;pRPLC_033_33_B;nRPLC_033_33_B"}
},
{
"Subject ID":"33",
"Sample ID":"033_36_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"36.7","DOL":"-2","RAW_FILE_NAME":"pHILIC_033_36_C;nHILIC_033_36_C;pRPLC_033_36_C;nRPLC_033_36_C"}
},
{
"Subject ID":"34",
"Sample ID":"034_26_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"26.9","DOL":"-90","RAW_FILE_NAME":"pHILIC_034_26_A;nHILIC_034_26_A;pRPLC_034_26_A;nRPLC_034_26_A"}
},
{
"Subject ID":"34",
"Sample ID":"034_35_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"35.4","DOL":"-30","RAW_FILE_NAME":"pHILIC_034_35_B;nHILIC_034_35_B;pRPLC_034_35_B;nRPLC_034_35_B"}
},
{
"Subject ID":"34",
"Sample ID":"034_36_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"37.3","DOL":"-17","RAW_FILE_NAME":"pHILIC_034_36_C;nHILIC_034_36_C;pRPLC_034_36_C;nRPLC_034_36_C"}
},
{
"Subject ID":"35",
"Sample ID":"035_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.6","DOL":"-78","RAW_FILE_NAME":"pHILIC_035_27_A;nHILIC_035_27_A;pRPLC_035_27_A;nRPLC_035_27_A"}
},
{
"Subject ID":"35",
"Sample ID":"035_31_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"31.6","DOL":"-50","RAW_FILE_NAME":"pHILIC_035_31_B;nHILIC_035_31_B;pRPLC_035_31_B;nRPLC_035_31_B"}
},
{
"Subject ID":"35",
"Sample ID":"035_37_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"37.7","DOL":"-7","RAW_FILE_NAME":"pHILIC_035_37_C;nHILIC_035_37_C;pRPLC_035_37_C;nRPLC_035_37_C"}
},
{
"Subject ID":"36",
"Sample ID":"036_28_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"28.1","DOL":"-86","RAW_FILE_NAME":"pHILIC_036_28_A;nHILIC_036_28_A;pRPLC_036_28_A;nRPLC_036_28_A"}
},
{
"Subject ID":"36",
"Sample ID":"036_30_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"30.7","DOL":"-68","RAW_FILE_NAME":"pHILIC_036_30_B;nHILIC_036_30_B;pRPLC_036_30_B;nRPLC_036_30_B"}
},
{
"Subject ID":"36",
"Sample ID":"036_37_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"37","DOL":"-24","RAW_FILE_NAME":"pHILIC_036_37_C;nHILIC_036_37_C;pRPLC_036_37_C;nRPLC_036_37_C"}
},
{
"Subject ID":"40",
"Sample ID":"040_25_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"25.6","DOL":"-90","RAW_FILE_NAME":"pHILIC_040_25_A;nHILIC_040_25_A;pRPLC_040_25_A;nRPLC_040_25_A"}
},
{
"Subject ID":"40",
"Sample ID":"040_29_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"29.9","DOL":"-69","RAW_FILE_NAME":"pHILIC_040_29_B;nHILIC_040_29_B;pRPLC_040_29_B;nRPLC_040_29_B"}
},
{
"Subject ID":"40",
"Sample ID":"040_36_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"36.1","DOL":"-25","RAW_FILE_NAME":"pHILIC_040_36_C;nHILIC_040_36_C;pRPLC_040_36_C;nRPLC_040_36_C"}
},
{
"Subject ID":"41",
"Sample ID":"041_25_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"25.6","DOL":"-96","RAW_FILE_NAME":"pHILIC_041_25_A;nHILIC_041_25_A;pRPLC_041_25_A;nRPLC_041_25_A"}
},
{
"Subject ID":"41",
"Sample ID":"041_30_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"30.1","DOL":"-64","RAW_FILE_NAME":"pHILIC_041_30_B;nHILIC_041_30_B;pRPLC_041_30_B;nRPLC_041_30_B"}
},
{
"Subject ID":"41",
"Sample ID":"041_37_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"37.6","DOL":"-12","RAW_FILE_NAME":"pHILIC_041_37_C;nHILIC_041_37_C;pRPLC_041_37_C;nRPLC_041_37_C"}
},
{
"Subject ID":"42",
"Sample ID":"042_24_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"24.1","DOL":"-106","RAW_FILE_NAME":"pHILIC_042_24_A;nHILIC_042_24_A;pRPLC_042_24_A;nRPLC_042_24_A"}
},
{
"Subject ID":"42",
"Sample ID":"042_27_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"27.4","DOL":"-83","RAW_FILE_NAME":"pHILIC_042_27_B;nHILIC_042_27_B;pRPLC_042_27_B;nRPLC_042_27_B"}
},
{
"Subject ID":"42",
"Sample ID":"042_37_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"37","DOL":"-16","RAW_FILE_NAME":"pHILIC_042_37_C;nHILIC_042_37_C;pRPLC_042_37_C;nRPLC_042_37_C"}
},
{
"Subject ID":"43",
"Sample ID":"043_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.7","DOL":"-91","RAW_FILE_NAME":"pHILIC_043_27_A;nHILIC_043_27_A;pRPLC_043_27_A;nRPLC_043_27_A"}
},
{
"Subject ID":"43",
"Sample ID":"043_38_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"38.1","DOL":"-18","RAW_FILE_NAME":"pHILIC_043_38_B;nHILIC_043_38_B;pRPLC_043_38_B;nRPLC_043_38_B"}
},
{
"Subject ID":"43",
"Sample ID":"043_39_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"39.1","DOL":"-11","RAW_FILE_NAME":"pHILIC_043_39_C;nHILIC_043_39_C;pRPLC_043_39_C;nRPLC_043_39_C"}
},
{
"Subject ID":"44",
"Sample ID":"044_30_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"30","DOL":"-68","RAW_FILE_NAME":"pHILIC_044_30_A;nHILIC_044_30_A;pRPLC_044_30_A;nRPLC_044_30_A"}
},
{
"Subject ID":"44",
"Sample ID":"044_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"36.3","DOL":"-24","RAW_FILE_NAME":"pHILIC_044_36_B;nHILIC_044_36_B;pRPLC_044_36_B;nRPLC_044_36_B"}
},
{
"Subject ID":"44",
"Sample ID":"044_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38.3","DOL":"-10","RAW_FILE_NAME":"pHILIC_044_38_C;nHILIC_044_38_C;pRPLC_044_38_C;nRPLC_044_38_C"}
},
{
"Subject ID":"45",
"Sample ID":"045_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.4","DOL":"-81","RAW_FILE_NAME":"pHILIC_045_27_A;nHILIC_045_27_A;pRPLC_045_27_A;nRPLC_045_27_A"}
},
{
"Subject ID":"45",
"Sample ID":"045_33_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"33.1","DOL":"-41","RAW_FILE_NAME":"pHILIC_045_33_B;nHILIC_045_33_B;pRPLC_045_33_B;nRPLC_045_33_B"}
},
{
"Subject ID":"45",
"Sample ID":"045_37_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"37.1","DOL":"-13","RAW_FILE_NAME":"pHILIC_045_37_C;nHILIC_045_37_C;pRPLC_045_37_C;nRPLC_045_37_C"}
},
{
"Subject ID":"50",
"Sample ID":"050_32_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"32","DOL":"-46","RAW_FILE_NAME":"pHILIC_050_32_A;nHILIC_050_32_A;pRPLC_050_32_A;nRPLC_050_32_A"}
},
{
"Subject ID":"50",
"Sample ID":"050_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"36.1","DOL":"-17","RAW_FILE_NAME":"pHILIC_050_36_B;nHILIC_050_36_B;pRPLC_050_36_B;nRPLC_050_36_B"}
},
{
"Subject ID":"50",
"Sample ID":"050_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38","DOL":"-4","RAW_FILE_NAME":"pHILIC_050_38_C;nHILIC_050_38_C;pRPLC_050_38_C;nRPLC_050_38_C"}
},
{
"Subject ID":"51",
"Sample ID":"051_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.7","DOL":"-94","RAW_FILE_NAME":"pHILIC_051_27_A;nHILIC_051_27_A;pRPLC_051_27_A;nRPLC_051_27_A"}
},
{
"Subject ID":"51",
"Sample ID":"051_38_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"38.6","DOL":"-18","RAW_FILE_NAME":"pHILIC_051_38_B;nHILIC_051_38_B;pRPLC_051_38_B;nRPLC_051_38_B"}
},
{
"Subject ID":"51",
"Sample ID":"051_39_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"39.6","DOL":"-11","RAW_FILE_NAME":"pHILIC_051_39_C;nHILIC_051_39_C;pRPLC_051_39_C;nRPLC_051_39_C"}
},
{
"Subject ID":"52",
"Sample ID":"052_24_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"24.4","DOL":"-108","RAW_FILE_NAME":"pHILIC_052_24_A;nHILIC_052_24_A;pRPLC_052_24_A;nRPLC_052_24_A"}
},
{
"Subject ID":"52",
"Sample ID":"052_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"36.3","DOL":"-25","RAW_FILE_NAME":"pHILIC_052_36_B;nHILIC_052_36_B;pRPLC_052_36_B;nRPLC_052_36_B"}
},
{
"Subject ID":"52",
"Sample ID":"052_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38.4","DOL":"-10","RAW_FILE_NAME":"pHILIC_052_38_C;nHILIC_052_38_C;pRPLC_052_38_C;nRPLC_052_38_C"}
},
{
"Subject ID":"54",
"Sample ID":"054_32_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"32.3","DOL":"-44","RAW_FILE_NAME":"pHILIC_054_32_A;nHILIC_054_32_A;pRPLC_054_32_A;nRPLC_054_32_A"}
},
{
"Subject ID":"55",
"Sample ID":"055_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27","DOL":"-87","RAW_FILE_NAME":"pHILIC_055_27_A;nHILIC_055_27_A;pRPLC_055_27_A;nRPLC_055_27_A"}
},
{
"Subject ID":"55",
"Sample ID":"055_35_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"35","DOL":"-31","RAW_FILE_NAME":"pHILIC_055_35_B;nHILIC_055_35_B;pRPLC_055_35_B;nRPLC_055_35_B"}
},
{
"Subject ID":"55",
"Sample ID":"055_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38","DOL":"-10","RAW_FILE_NAME":"pHILIC_055_38_C;nHILIC_055_38_C;pRPLC_055_38_C;nRPLC_055_38_C"}
},
{
"Subject ID":"56",
"Sample ID":"056_25_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"25.9","DOL":"-90","RAW_FILE_NAME":"pHILIC_056_25_A;nHILIC_056_25_A;pRPLC_056_25_A;nRPLC_056_25_A"}
},
{
"Subject ID":"56",
"Sample ID":"056_37_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"37.1","DOL":"-11","RAW_FILE_NAME":"pHILIC_056_37_B;nHILIC_056_37_B;pRPLC_056_37_B;nRPLC_056_37_B"}
},
{
"Subject ID":"56",
"Sample ID":"056_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38","DOL":"-5","RAW_FILE_NAME":"pHILIC_056_38_C;nHILIC_056_38_C;pRPLC_056_38_C;nRPLC_056_38_C"}
},
{
"Subject ID":"57",
"Sample ID":"057_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.1","DOL":"-84","RAW_FILE_NAME":"pHILIC_057_27_A;nHILIC_057_27_A;pRPLC_057_27_A;nRPLC_057_27_A"}
},
{
"Subject ID":"57",
"Sample ID":"057_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"36.6","DOL":"-16","RAW_FILE_NAME":"pHILIC_057_36_B;nHILIC_057_36_B;pRPLC_057_36_B;nRPLC_057_36_B"}
},
{
"Subject ID":"57",
"Sample ID":"057_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38.9","DOL":"-2","RAW_FILE_NAME":"pHILIC_057_38_C;nHILIC_057_38_C;pRPLC_057_38_C;nRPLC_057_38_C"}
},
{
"Subject ID":"63",
"Sample ID":"063_30_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"30.6","DOL":"-69","RAW_FILE_NAME":"pHILIC_063_30_A;nHILIC_063_30_A;pRPLC_063_30_A;nRPLC_063_30_A"}
},
{
"Subject ID":"63",
"Sample ID":"063_38_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"38.3","DOL":"-15","RAW_FILE_NAME":"pHILIC_063_38_B;nHILIC_063_38_B;pRPLC_063_38_B;nRPLC_063_38_B"}
},
{
"Subject ID":"63",
"Sample ID":"063_40_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"40.3","DOL":"-1","RAW_FILE_NAME":"pHILIC_063_40_C;nHILIC_063_40_C;pRPLC_063_40_C;nRPLC_063_40_C"}
},
{
"Subject ID":"65",
"Sample ID":"065_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.7","DOL":"-79","RAW_FILE_NAME":"pHILIC_065_27_A;nHILIC_065_27_A;pRPLC_065_27_A;nRPLC_065_27_A"}
},
{
"Subject ID":"65",
"Sample ID":"065_38_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"38.3","DOL":"-5","RAW_FILE_NAME":"pHILIC_065_38_B;nHILIC_065_38_B;pRPLC_065_38_B;nRPLC_065_38_B"}
},
{
"Subject ID":"67",
"Sample ID":"067_30_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"30.6","DOL":"-52","RAW_FILE_NAME":"pHILIC_067_30_A;nHILIC_067_30_A;pRPLC_067_30_A;nRPLC_067_30_A"}
},
{
"Subject ID":"67",
"Sample ID":"067_37_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"37","DOL":"-7","RAW_FILE_NAME":"pHILIC_067_37_B;nHILIC_067_37_B;pRPLC_067_37_B;nRPLC_067_37_B"}
},
{
"Subject ID":"68",
"Sample ID":"068_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.3","DOL":"-89","RAW_FILE_NAME":"pHILIC_068_27_A;nHILIC_068_27_A;pRPLC_068_27_A;nRPLC_068_27_A"}
},
{
"Subject ID":"68",
"Sample ID":"068_37_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"37.1","DOL":"-20","RAW_FILE_NAME":"pHILIC_068_37_B;nHILIC_068_37_B;pRPLC_068_37_B;nRPLC_068_37_B"}
},
{
"Subject ID":"68",
"Sample ID":"068_39_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"39.1","DOL":"-6","RAW_FILE_NAME":"pHILIC_068_39_C;nHILIC_068_39_C;pRPLC_068_39_C;nRPLC_068_39_C"}
},
{
"Subject ID":"72",
"Sample ID":"072_24_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"24.9","DOL":"-113","RAW_FILE_NAME":"pHILIC_072_24_A;nHILIC_072_24_A;pRPLC_072_24_A;nRPLC_072_24_A"}
},
{
"Subject ID":"72",
"Sample ID":"072_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"37.4","DOL":"-25","RAW_FILE_NAME":"pHILIC_072_36_B;nHILIC_072_36_B;pRPLC_072_36_B;nRPLC_072_36_B"}
},
{
"Subject ID":"72",
"Sample ID":"072_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"39.4","DOL":"-11","RAW_FILE_NAME":"pHILIC_072_38_C;nHILIC_072_38_C;pRPLC_072_38_C;nRPLC_072_38_C"}
},
{
"Subject ID":"73",
"Sample ID":"073_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.4","DOL":"-79","RAW_FILE_NAME":"pHILIC_073_27_A;nHILIC_073_27_A;pRPLC_073_27_A;nRPLC_073_27_A"}
},
{
"Subject ID":"74",
"Sample ID":"074_30_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"30.6","DOL":"-58","RAW_FILE_NAME":"pHILIC_074_30_A;nHILIC_074_30_A;pRPLC_074_30_A;nRPLC_074_30_A"}
},
{
"Subject ID":"74",
"Sample ID":"074_37_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"37.6","DOL":"-9","RAW_FILE_NAME":"pHILIC_074_37_B;nHILIC_074_37_B;pRPLC_074_37_B;nRPLC_074_37_B"}
},
{
"Subject ID":"74",
"Sample ID":"074_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38.6","DOL":"-2","RAW_FILE_NAME":"pHILIC_074_38_C;nHILIC_074_38_C;pRPLC_074_38_C;nRPLC_074_38_C"}
},
{
"Subject ID":"75",
"Sample ID":"075_31_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"31.9","DOL":"-53","RAW_FILE_NAME":"pHILIC_075_31_A;nHILIC_075_31_A;pRPLC_075_31_A;nRPLC_075_31_A"}
},
{
"Subject ID":"75",
"Sample ID":"075_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"36.9","DOL":"-18","RAW_FILE_NAME":"pHILIC_075_36_B;nHILIC_075_36_B;pRPLC_075_36_B;nRPLC_075_36_B"}
},
{
"Subject ID":"75",
"Sample ID":"075_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38.4","DOL":"-7","RAW_FILE_NAME":"pHILIC_075_38_C;nHILIC_075_38_C;pRPLC_075_38_C;nRPLC_075_38_C"}
},
{
"Subject ID":"83",
"Sample ID":"083_28_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"28.1","DOL":"-78","RAW_FILE_NAME":"pHILIC_083_28_A;nHILIC_083_28_A;pRPLC_083_28_A;nRPLC_083_28_A"}
},
{
"Subject ID":"83",
"Sample ID":"083_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"36.9","DOL":"-17","RAW_FILE_NAME":"pHILIC_083_36_B;nHILIC_083_36_B;pRPLC_083_36_B;nRPLC_083_36_B"}
},
{
"Subject ID":"83",
"Sample ID":"083_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38.3","DOL":"-7","RAW_FILE_NAME":"pHILIC_083_38_C;nHILIC_083_38_C;pRPLC_083_38_C;nRPLC_083_38_C"}
},
{
"Subject ID":"86",
"Sample ID":"086_30_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"30","DOL":"-71","RAW_FILE_NAME":"pHILIC_086_30_A;nHILIC_086_30_A;pRPLC_086_30_A;nRPLC_086_30_A"}
},
{
"Subject ID":"86",
"Sample ID":"086_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"36.6","DOL":"-25","RAW_FILE_NAME":"pHILIC_086_36_B;nHILIC_086_36_B;pRPLC_086_36_B;nRPLC_086_36_B"}
},
{
"Subject ID":"87",
"Sample ID":"087_30_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"30.1","DOL":"-60","RAW_FILE_NAME":"pHILIC_087_30_A;nHILIC_087_30_A;pRPLC_087_30_A;nRPLC_087_30_A"}
},
{
"Subject ID":"87",
"Sample ID":"087_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"37.1","DOL":"-11","RAW_FILE_NAME":"pHILIC_087_36_B;nHILIC_087_36_B;pRPLC_087_36_B;nRPLC_087_36_B"}
},
{
"Subject ID":"87",
"Sample ID":"087_37_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38.1","DOL":"-4","RAW_FILE_NAME":"pHILIC_087_37_C;nHILIC_087_37_C;pRPLC_087_37_C;nRPLC_087_37_C"}
},
{
"Subject ID":"91",
"Sample ID":"091_30_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"30.1","DOL":"-64","RAW_FILE_NAME":"pHILIC_091_30_A;nHILIC_091_30_A;pRPLC_091_30_A;nRPLC_091_30_A"}
},
{
"Subject ID":"91",
"Sample ID":"091_37_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"37.3","DOL":"-11","RAW_FILE_NAME":"pHILIC_091_37_B;nHILIC_091_37_B;pRPLC_091_37_B;nRPLC_091_37_B"}
},
{
"Subject ID":"91",
"Sample ID":"091_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38.3","DOL":"-4","RAW_FILE_NAME":"pHILIC_091_38_C;nHILIC_091_38_C;pRPLC_091_38_C;nRPLC_091_38_C"}
},
{
"Subject ID":"93",
"Sample ID":"093_27_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"27.7","DOL":"-82","RAW_FILE_NAME":"pHILIC_093_27_A;nHILIC_093_27_A;pRPLC_093_27_A;nRPLC_093_27_A"}
},
{
"Subject ID":"93",
"Sample ID":"093_38_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"38.3","DOL":"-8","RAW_FILE_NAME":"pHILIC_093_38_B;nHILIC_093_38_B;pRPLC_093_38_B;nRPLC_093_38_B"}
},
{
"Subject ID":"93",
"Sample ID":"093_39_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"39.3","DOL":"-1","RAW_FILE_NAME":"pHILIC_093_39_C;nHILIC_093_39_C;pRPLC_093_39_C;nRPLC_093_39_C"}
},
{
"Subject ID":"98",
"Sample ID":"098_26_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"26.7","DOL":"-93","RAW_FILE_NAME":"pHILIC_098_26_A;nHILIC_098_26_A;pRPLC_098_26_A;nRPLC_098_26_A"}
},
{
"Subject ID":"98",
"Sample ID":"098_36_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"36.6","DOL":"-24","RAW_FILE_NAME":"pHILIC_098_36_B;nHILIC_098_36_B;pRPLC_098_36_B;nRPLC_098_36_B"}
},
{
"Subject ID":"98",
"Sample ID":"098_38_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"38.7","DOL":"-9","RAW_FILE_NAME":"pHILIC_098_38_C;nHILIC_098_38_C;pRPLC_098_38_C;nRPLC_098_38_C"}
},
{
"Subject ID":"99",
"Sample ID":"099_24_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"24.6","DOL":"-106","RAW_FILE_NAME":"pHILIC_099_24_A;nHILIC_099_24_A;pRPLC_099_24_A;nRPLC_099_24_A"}
},
{
"Subject ID":"99",
"Sample ID":"099_38_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"38.7","DOL":"-7","RAW_FILE_NAME":"pHILIC_099_38_B;nHILIC_099_38_B;pRPLC_099_38_B;nRPLC_099_38_B"}
},
{
"Subject ID":"99",
"Sample ID":"099_39_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"39.7","DOL":"-","RAW_FILE_NAME":"pHILIC_099_39_C;nHILIC_099_39_C;pRPLC_099_39_C;nRPLC_099_39_C"}
},
{
"Subject ID":"100",
"Sample ID":"100_29_A",
"Factors":{"Timepoint":"G1"},
"Additional sample data":{"EGA_sampling":"29.4","DOL":"-71","RAW_FILE_NAME":"pHILIC_100_29_A;nHILIC_100_29_A;pRPLC_100_29_A;nRPLC_100_29_A"}
},
{
"Subject ID":"100",
"Sample ID":"100_37_B",
"Factors":{"Timepoint":"G2"},
"Additional sample data":{"EGA_sampling":"37.4","DOL":"-15","RAW_FILE_NAME":"pHILIC_100_37_B;nHILIC_100_37_B;pRPLC_100_37_B;nRPLC_100_37_B"}
},
{
"Subject ID":"100",
"Sample ID":"100_39_C",
"Factors":{"Timepoint":"G3"},
"Additional sample data":{"EGA_sampling":"39.4","DOL":"-1","RAW_FILE_NAME":"pHILIC_100_39_C;nHILIC_100_39_C;pRPLC_100_39_C;nRPLC_100_39_C"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Healthy pregnant women receiving routine antepartum care were eligible for the study if they were within 18 to 50 years of age, body mass index (BMI) < 40 in their 2nd or 3rd trimester of pregnancy as determined by their clinician using LMP and ultrasound estimates of GA, and had no immune-modifying co-morbidities or medication usage. Participants were followed longitudinally until parturition, collecting 1-3 blood samples throughout the third trimester (n = 53 participants). Blood was collected into EDTA tubes, kept on ice, and centrifuged (1500 x g, 20 min) at 4°C within 60 min. Separated plasma was stored at –80°C until further processing.","SAMPLE_TYPE":"Blood (plasma)","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"There was no treatment."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Plasma samples were thawed on ice, prepared and analyzed randomly as previously described (Contrepois et al., 2015). Briefly, metabolites were extracted using 1:1:1 acetone:acetonitrile:methanol, evaporated to dryness under nitrogen and reconstituted in 1:1 methanol:water before analysis. Each sample was spiked-in with 15 analytical-grade internal standards (IS)."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"RPLC experiments were performed using a Zorbax SBaq column 2.1 x 50 mm, 1.7 μm, 100Å (Agilent Technologies) and mobile phase solvents consisting of 0.06% acetic acid in water (A) and 0.06% acetic acid in methanol (B). (Contrepois et al., 2015)","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Thermo Dionex Ultimate 3000 RS","COLUMN_NAME":"Agilent Zorbax SBaq (50 x 2.1 mm, 1.7 μm)","FLOW_RATE":"0.6 ml/min","COLUMN_TEMPERATURE":"60","SOLVENT_A":"0.06% acetic acid in water","SOLVENT_B":"0.06% acetic acid in methanol"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","OPERATOR_NAME":"Kevin Contrepois","DETECTOR_TYPE":"Orbitrap","DATA_FORMAT":".RAW"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"Data processing. Data from each mode were independently processed using Progenesis QI software (v2.3, Nonlinear Dynamics, Durham, NC). Metabolic features from blanks and that did not show sufficient linearity upon dilution in QC samples (r < 0.6) were discarded. Only metabolic features present in >2/3 of the samples were kept for further analysis. Inter- and intra-batch variations were corrected using the LOESS (locally estimated scatterplot smoothing Local Regression) normalization method on QC injected repetitively along the batches (span = 0.75). Data were acquired in five and three batches for HILIC and RPLC modes, respectively. Missing values were imputed by drawing from a random distribution of low values in the corresponding sample. Data from each mode were merged and resulted in a dataset containing 3,529 metabolic features that was used for downstream analysis. Metabolic features of interest were tentatively identified by matching fragmentation spectra and retention time to analytical-grade standards when possible or matching experimental MS/MS to fragmentation spectra in publicly available databases.","CAPILLARY_TEMPERATURE":"375C","CAPILLARY_VOLTAGE":"3.4kV","COLLISION_ENERGY":"25 & 50 NCE","COLLISION_GAS":"N2","DRY_GAS_TEMP":"310C","MS_RESULTS_FILE":"ST001681_AN002744_Results.txt UNITS:MS Counts Has m/z:Yes Has RT:Yes RT units:Minutes"}

}