{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001728","ANALYSIS_ID":"AN002813","VERSION":"1","CREATED_ON":"March 24, 2021, 2:44 pm"},

"PROJECT":{"PROJECT_TITLE":"Metabolomics and metagenomics of metformin","PROJECT_SUMMARY":"Metformin affects the gut microbiome and altered microbiota may contribute to the hypoglycemic effect of metformin. Metabolomic analysis can be useful to elucidate the potential underlying mechanisms of the hypoglycemic effect according to the change in the microbiome and metabolites induced by the administration of metformin.","INSTITUTE":"Seoul National University","DEPARTMENT":"Department of Clinical Pharmacology and Therapeutics, College of Medicine and Hospital","LAST_NAME":"Lee","FIRST_NAME":"Yujin","ADDRESS":"101 Daehak-ro, Jongno-gu, Seoul 110-799, Korea","EMAIL":"yoojinlee@snu.ac.kr","PHONE":"+821033804686"},

"STUDY":{"STUDY_TITLE":"Metabolomics and metagenomics of metformin (Urine)","STUDY_SUMMARY":"Metformin affects the gut microbiome and altered microbiota may contribute to the hypoglycemic effect of metformin. Metabolomic analysis can be useful to elucidate the potential underlying mechanisms of the hypoglycemic effect according to the change in the microbiome and metabolites induced by the administration of metformin.","INSTITUTE":"Seoul National University","DEPARTMENT":"Department of Clinical Pharmacology and Therapeutics, College of Medicine and Hospital","LAST_NAME":"Lee","FIRST_NAME":"Yujin","ADDRESS":"101 Daehak-ro, Jongno-gu, Seoul 110-799, Korea","EMAIL":"yoojinlee@snu.ac.kr","PHONE":"+821033804686"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","GENDER":"Male"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"R101",
"Sample ID":"R101-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R101-P1_1"}
},
{
"Subject ID":"R102",
"Sample ID":"R102-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R102-P1_1"}
},
{
"Subject ID":"R103",
"Sample ID":"R103-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R103-P1_1"}
},
{
"Subject ID":"R105",
"Sample ID":"R105-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R105-P1_1"}
},
{
"Subject ID":"R106",
"Sample ID":"R106-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R106-P1_1"}
},
{
"Subject ID":"R107",
"Sample ID":"R107-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R107-P1_1"}
},
{
"Subject ID":"R109",
"Sample ID":"R109-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R109-P1_1"}
},
{
"Subject ID":"R110",
"Sample ID":"R110-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R110-P1_1"}
},
{
"Subject ID":"R111",
"Sample ID":"R111-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R111-P1_1"}
},
{
"Subject ID":"R112",
"Sample ID":"R112-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R112-P1_1"}
},
{
"Subject ID":"R113",
"Sample ID":"R113-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R113-P1_1"}
},
{
"Subject ID":"R114",
"Sample ID":"R114-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R114-P1_1"}
},
{
"Subject ID":"R201",
"Sample ID":"R201-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R201-P1_1"}
},
{
"Subject ID":"R202",
"Sample ID":"R202-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R202-P1_1"}
},
{
"Subject ID":"R203",
"Sample ID":"R203-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R203-P1_1"}
},
{
"Subject ID":"R204",
"Sample ID":"R204-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R204-P1_1"}
},
{
"Subject ID":"R205",
"Sample ID":"R205-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R205-P1_1"}
},
{
"Subject ID":"R206",
"Sample ID":"R206-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R206-P1_1"}
},
{
"Subject ID":"R207",
"Sample ID":"R207-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R207-P1_1"}
},
{
"Subject ID":"R210",
"Sample ID":"R210-P1",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"R210-P1_1"}
},
{
"Subject ID":"R101",
"Sample ID":"R101-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R101-P2_1"}
},
{
"Subject ID":"R102",
"Sample ID":"R102-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R102-P2_1"}
},
{
"Subject ID":"R103",
"Sample ID":"R103-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R103-P2_1"}
},
{
"Subject ID":"R105",
"Sample ID":"R105-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R105-P2_1"}
},
{
"Subject ID":"R106",
"Sample ID":"R106-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R106-P2_1"}
},
{
"Subject ID":"R107",
"Sample ID":"R107-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R107-P2_1"}
},
{
"Subject ID":"R109",
"Sample ID":"R109-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R109-P2_1"}
},
{
"Subject ID":"R110",
"Sample ID":"R110-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R110-P2_1"}
},
{
"Subject ID":"R111",
"Sample ID":"R111-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R111-P2_1"}
},
{
"Subject ID":"R112",
"Sample ID":"R112-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R112-P2_1"}
},
{
"Subject ID":"R113",
"Sample ID":"R113-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R113-P2_1"}
},
{
"Subject ID":"R114",
"Sample ID":"R114-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R114-P2_1"}
},
{
"Subject ID":"R201",
"Sample ID":"R201-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R201-P2_1"}
},
{
"Subject ID":"R202",
"Sample ID":"R202-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R202-P2_1"}
},
{
"Subject ID":"R203",
"Sample ID":"R203-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R203-P2_1"}
},
{
"Subject ID":"R204",
"Sample ID":"R204-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R204-P2_1"}
},
{
"Subject ID":"R205",
"Sample ID":"R205-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R205-P2_1"}
},
{
"Subject ID":"R206",
"Sample ID":"R206-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R206-P2_1"}
},
{
"Subject ID":"R207",
"Sample ID":"R207-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R207-P2_1"}
},
{
"Subject ID":"R210",
"Sample ID":"R210-P2",
"Factors":{"Gender":"Male","Race":"Asian","Group":"Treated"},
"Additional sample data":{"RAW_FILE_NAME":"R210-P2_1"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"We recruited and included 20 healthy adult male subgects","SAMPLE_TYPE":"Urine"},

"TREATMENT":{"TREATMENT_SUMMARY":"The subjects received oral metformin 1000mg twice daily."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Samples were extracted twice."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Agilent 7890B","COLUMN_NAME":"Restek Rtx-5Sil MS (30 x 0.25mm, 0.25um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Leco Pegasus HT TOF","INSTRUMENT_TYPE":"GC-TOF","MS_TYPE":"EI","ION_MODE":"NEGATIVE","MS_COMMENTS":"Leco® ChromaTOF-GC Software v4.72.0.0"},

"MS_METABOLITE_DATA":{
"Units":"intensity",

"Data":[{"Metabolite":"Scyllo-inositol","R101-P1":"0.775680133","R102-P1":"0.676948141","R103-P1":"0.914080825","R105-P1":"0.974177724","R106-P1":"1.059524914","R107-P1":"1.45431027","R109-P1":"0.547975976","R110-P1":"0.806802568","R111-P1":"0.850966239","R112-P1":"0.345792855","R113-P1":"0.407000644","R114-P1":"0.833610251","R201-P1":"0.887562585","R202-P1":"0.985728461","R203-P1":"0.550896979","R204-P1":"0.897479566","R205-P1":"0.640317419","R206-P1":"0.707382908","R207-P1":"0.901477048","R210-P1":"0.536680276","R101-P2":"0.560876329","R102-P2":"0.434182067","R103-P2":"0.625445316","R105-P2":"1.161821012","R106-P2":"1.115807835","R107-P2":"1.187141427","R109-P2":"0.407947345","R110-P2":"1.085705385","R111-P2":"0.662253868","R112-P2":"0.257204525","R113-P2":"0.488432927","R114-P2":"0.785223836","R201-P2":"0.46911833","R202-P2":"0.669760276","R203-P2":"0.320625712","R204-P2":"0.594400592","R205-P2":"0.415903087","R206-P2":"0.824921909","R207-P2":"0.554993259","R210-P2":"0.453862589"},{"Metabolite":"Serine","R101-P1":"8.574855878","R102-P1":"15.57940148","R103-P1":"8.060876688","R105-P1":"33.45496355","R106-P1":"9.813246766","R107-P1":"9.07376719","R109-P1":"6.154598504","R110-P1":"11.98267502","R111-P1":"8.060808781","R112-P1":"9.835194307","R113-P1":"9.410130267","R114-P1":"9.223172424","R201-P1":"10.08602716","R202-P1":"13.27571224","R203-P1":"10.74976895","R204-P1":"9.423297726","R205-P1":"12.30059599","R206-P1":"18.27624846","R207-P1":"8.236032357","R210-P1":"10.86133293","R101-P2":"6.696116957","R102-P2":"8.601567291","R103-P2":"6.196010096","R105-P2":"21.97455448","R106-P2":"9.180172449","R107-P2":"11.1196796","R109-P2":"3.32565889","R110-P2":"7.863334716","R111-P2":"5.34018039","R112-P2":"9.34492491","R113-P2":"5.833731609","R114-P2":"6.438870405","R201-P2":"5.144673458","R202-P2":"8.189553508","R203-P2":"4.673384429","R204-P2":"3.127350818","R205-P2":"5.275600805","R206-P2":"14.6766768","R207-P2":"4.914119344","R210-P2":"5.653720898"},{"Metabolite":"L-Pyroglutamic 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"Metabolites":[{"Metabolite":"Scyllo-inositol","PubChem":"892","KEGG":"C06153"},{"Metabolite":"Serine","PubChem":"5951","KEGG":"C00065"},{"Metabolite":"L-Pyroglutamic acid","PubChem":"7405","KEGG":"C01879"},{"Metabolite":"Threonine","PubChem":"6288","KEGG":"C00188"},{"Metabolite":"Alanine","PubChem":"5950","KEGG":"C00041"},{"Metabolite":"Glycine","PubChem":"750","KEGG":"C00037"},{"Metabolite":"β-Alanine","PubChem":"239","KEGG":"C00099"},{"Metabolite":"Valine","PubChem":"6287","KEGG":"C00183"},{"Metabolite":"Lysine","PubChem":"5962","KEGG":"C00047"},{"Metabolite":"Phenylalanine","PubChem":"6140","KEGG":"C00079"},{"Metabolite":"Hippuric Acid","PubChem":"464","KEGG":"C01586"},{"Metabolite":"Glyceric acid","PubChem":"439194","KEGG":"C00258"},{"Metabolite":"D-Galactose","PubChem":"439357","KEGG":"C00984"},{"Metabolite":"Ribonic acid","PubChem":"5460677","KEGG":"C01685"},{"Metabolite":"D-Glucuronic acid","PubChem":"94715","KEGG":"C00191"},{"Metabolite":"Threonic acid","PubChem":"151152","KEGG":"C01620"},{"Metabolite":"1,5-Anhydrosorbitol","PubChem":"64960","KEGG":"C07326"},{"Metabolite":"Adonitol","PubChem":"-","KEGG":"C00474"},{"Metabolite":"2,3-Dihydroxybutyric acid","PubChem":"-","KEGG":"-"},{"Metabolite":"2,4-Dihydroxybutyric acid","PubChem":"192742","KEGG":"-"},{"Metabolite":"Glycolic acid","PubChem":"757","KEGG":"C03547"},{"Metabolite":"Lactic acid","PubChem":"61503","KEGG":"C00186"},{"Metabolite":"3,4-Dihydroxybutyric acid","PubChem":"-","KEGG":"-"},{"Metabolite":"Hypoxanthine","PubChem":"790","KEGG":"C00262"},{"Metabolite":"3-Hydroxyisobutyric acid","PubChem":"87","KEGG":"C06001"}]
}

}