{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002291","ANALYSIS_ID":"AN003743","VERSION":"1","CREATED_ON":"September 10, 2022, 12:44 pm"},

"PROJECT":{"PROJECT_TITLE":"Integrated metabolic and inflammatory signatures associated with severity, fatality, and recovery of COVID-19","PROJECT_TYPE":"Research","PROJECT_SUMMARY":"Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been associated with physiological alterations that provide insights into the pathogenesis of the disease. Moreover, factors that drive recovery from COVID-19 can be explored to identify correlates of protection. The cellular metabolism represents a potential target to improve survival upon severe disease, but the associations between the metabolism and the inflammatory response during COVID-19 are not well defined. We analyzed blood laboratorial parameters, cytokines, and metabolomes of 150 individuals with mild to severe disease, of which 33 progressed to a fatal outcome. A subset of 20 individuals was followed-up after hospital discharge and recovery of acute disease. We used hierarchical community networks to integrate metabolomics profiles with cytokines and markers of inflammation, coagulation, and tissue damage. Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) promotes significant alterations in the plasma metabolome, whose activity varies according to disease severity and correlates with oxygen saturation. Differential metabolism underlying death was marked by amino acids and related metabolites, such as glutamate, tryptophan and oxoproline; and lipids, including progesterone, phosphocholine and lysophosphatidylcholines (lysoPCs). Individuals that recovered from severe disease displayed persistent alterations enriched for metabolism of purines, phosphatidylinositol phosphate and glycolysis. Recovery of mild disease was associated with vitamin E metabolism. Data integration shows that the metabolic response is a hub connecting other biological features during disease and recovery. Infection by SARS-CoV-2 induces concerted activity of metabolic and inflammatory responses that depend on disease severity and collectively predict clinical outcomes of COVID-19.","INSTITUTE":"Federal University of Goiás","LAST_NAME":"Gardinassi","FIRST_NAME":"Luiz Gustavo","ADDRESS":"R. 235 s/n - Institute of Tropical Pathology and Public Health - Federal University of Goiás","EMAIL":"luizgardinassi@ufg.br","PHONE":"+55 62 3209-6530"},

"STUDY":{"STUDY_TITLE":"Integrated metabolic and inflammatory signatures associated with severity, fatality, and recovery of COVID-19","STUDY_TYPE":"Research","STUDY_SUMMARY":"Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been associated with physiological alterations that provide insights into the pathogenesis of the disease. Moreover, factors that drive recovery from COVID-19 can be explored to identify correlates of protection. The cellular metabolism represents a potential target to improve survival upon severe disease, but the associations between the metabolism and the inflammatory response during COVID-19 are not well defined. We analyzed blood laboratorial parameters, cytokines, and metabolomes of 150 individuals with mild to severe disease, of which 33 progressed to a fatal outcome. A subset of 20 individuals was followed-up after hospital discharge and recovery of acute disease. We used hierarchical community networks to integrate metabolomics profiles with cytokines and markers of inflammation, coagulation, and tissue damage. Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) promotes significant alterations in the plasma metabolome, whose activity varies according to disease severity and correlates with oxygen saturation. Differential metabolism underlying death was marked by amino acids and related metabolites, such as glutamate, tryptophan and oxoproline; and lipids, including progesterone, phosphocholine and lysophosphatidylcholines (lysoPCs). Individuals that recovered from severe disease displayed persistent alterations enriched for metabolism of purines, phosphatidylinositol phosphate and glycolysis. Recovery of mild disease was associated with vitamin E metabolism. Data integration shows that the metabolic response is a hub connecting other biological features during disease and recovery. Infection by SARS-CoV-2 induces concerted activity of metabolic and inflammatory responses that depend on disease severity and collectively predict clinical outcomes of COVID-19.","INSTITUTE":"Institute of Tropical Pathology and Public Health - Federal University of Goiás","LAST_NAME":"Gardinassi","FIRST_NAME":"Luiz Gustavo","ADDRESS":"R. 235 s/n - Institute of Tropical Pathology and Public Health - Federal University of Goiás","EMAIL":"luizgardinassi@ufg.br","PHONE":"+55 62 3209-6530"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
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},
{
"Subject ID":"POOLED_PLASMA_2",
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"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_3.RAW","RAW_FILE_NAME":"ID_3.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_1",
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"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_30.RAW","RAW_FILE_NAME":"ID_30.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_2",
"Sample ID":"ID_31",
"Factors":{"Group":"pooled_plasma"},
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},
{
"Subject ID":"POOLED_PLASMA_1",
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"Factors":{"Group":"pooled_plasma"},
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},
{
"Subject ID":"POOLED_PLASMA_2",
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"Factors":{"Group":"pooled_plasma"},
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},
{
"Subject ID":"POOLED_PLASMA_1",
"Sample ID":"ID_97",
"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_97.RAW","RAW_FILE_NAME":"ID_97.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_2",
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"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_98.RAW","RAW_FILE_NAME":"ID_98.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_1",
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"Factors":{"Group":"pooled_plasma"},
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},
{
"Subject ID":"POOLED_PLASMA_2",
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"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_123.RAW","RAW_FILE_NAME":"ID_123.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_1",
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"Factors":{"Group":"pooled_plasma"},
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},
{
"Subject ID":"POOLED_PLASMA_2",
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"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_137.RAW","RAW_FILE_NAME":"ID_137.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_1",
"Sample ID":"ID_161",
"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_161.RAW","RAW_FILE_NAME":"ID_161.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_2",
"Sample ID":"ID_162",
"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_162.RAW","RAW_FILE_NAME":"ID_162.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_1",
"Sample ID":"ID_184",
"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_184.RAW","RAW_FILE_NAME":"ID_184.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_2",
"Sample ID":"ID_185",
"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_185.RAW","RAW_FILE_NAME":"ID_185.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_1",
"Sample ID":"ID_216",
"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_216.RAW","RAW_FILE_NAME":"ID_216.mzXML"}
},
{
"Subject ID":"POOLED_PLASMA_2",
"Sample ID":"ID_217",
"Factors":{"Group":"pooled_plasma"},
"Additional sample data":{"RAW_FILE_NAME":"ID_217.RAW","RAW_FILE_NAME":"ID_217.mzXML"}
},
{
"Subject ID":"NHC.CoV.047",
"Sample ID":"ID_4",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_4.RAW","RAW_FILE_NAME":"ID_4.mzXML"}
},
{
"Subject ID":"HC.CoV.264",
"Sample ID":"ID_5",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_5.RAW","RAW_FILE_NAME":"ID_5.mzXML"}
},
{
"Subject ID":"NHC.CoV.026",
"Sample ID":"ID_6",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_6.RAW","RAW_FILE_NAME":"ID_6.mzXML"}
},
{
"Subject ID":"HC.CoV.295",
"Sample ID":"ID_7",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_7.RAW","RAW_FILE_NAME":"ID_7.mzXML"}
},
{
"Subject ID":"NHC.CoV.027",
"Sample ID":"ID_8",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_8.RAW","RAW_FILE_NAME":"ID_8.mzXML"}
},
{
"Subject ID":"NHC.CoV.018_01",
"Sample ID":"ID_9",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_9.RAW","RAW_FILE_NAME":"ID_9.mzXML"}
},
{
"Subject ID":"NHC.CoV.018_02",
"Sample ID":"ID_10",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_10.RAW","RAW_FILE_NAME":"ID_10.mzXML"}
},
{
"Subject ID":"NHC.CoV.018_03",
"Sample ID":"ID_11",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_11.RAW","RAW_FILE_NAME":"ID_11.mzXML"}
},
{
"Subject ID":"NHC.CoV.014",
"Sample ID":"ID_12",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_12.RAW","RAW_FILE_NAME":"ID_12.mzXML"}
},
{
"Subject ID":"NHC.CoV.012",
"Sample ID":"ID_13",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_13.RAW","RAW_FILE_NAME":"ID_13.mzXML"}
},
{
"Subject ID":"NHC.CoV.011",
"Sample ID":"ID_14",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_14.RAW","RAW_FILE_NAME":"ID_14.mzXML"}
},
{
"Subject ID":"NHC.CoV.015",
"Sample ID":"ID_15",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_15.RAW","RAW_FILE_NAME":"ID_15.mzXML"}
},
{
"Subject ID":"HC.CoV.257",
"Sample ID":"ID_16",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_16.RAW","RAW_FILE_NAME":"ID_16.mzXML"}
},
{
"Subject ID":"HC.CoV.358",
"Sample ID":"ID_17",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_17.RAW","RAW_FILE_NAME":"ID_17.mzXML"}
},
{
"Subject ID":"HC.CoV.202",
"Sample ID":"ID_18",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_18.RAW","RAW_FILE_NAME":"ID_18.mzXML"}
},
{
"Subject ID":"HC.CoV.008",
"Sample ID":"ID_19",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_19.RAW","RAW_FILE_NAME":"ID_19.mzXML"}
},
{
"Subject ID":"HC.CoV.031",
"Sample ID":"ID_20",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_20.RAW","RAW_FILE_NAME":"ID_20.mzXML"}
},
{
"Subject ID":"HC.CoV.359",
"Sample ID":"ID_21",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_21.RAW","RAW_FILE_NAME":"ID_21.mzXML"}
},
{
"Subject ID":"NHC.CoV.016",
"Sample ID":"ID_22",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_22.RAW","RAW_FILE_NAME":"ID_22.mzXML"}
},
{
"Subject ID":"HC.CoV.157",
"Sample ID":"ID_23",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_23.RAW","RAW_FILE_NAME":"ID_23.mzXML"}
},
{
"Subject ID":"HC.CoV.003",
"Sample ID":"ID_24",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_24.RAW","RAW_FILE_NAME":"ID_24.mzXML"}
},
{
"Subject ID":"HC.CoV.360",
"Sample ID":"ID_25",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_25.RAW","RAW_FILE_NAME":"ID_25.mzXML"}
},
{
"Subject ID":"NHc.CoV.017",
"Sample ID":"ID_27",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_27.RAW","RAW_FILE_NAME":"ID_27.mzXML"}
},
{
"Subject ID":"Hc.CoV.110 (E P M F)",
"Sample ID":"ID_28",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_28.RAW","RAW_FILE_NAME":"ID_28.mzXML"}
},
{
"Subject ID":"Hc.CoV.136 (E A A)",
"Sample ID":"ID_29",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_29.RAW","RAW_FILE_NAME":"ID_29.mzXML"}
},
{
"Subject ID":"Hc.CoV.063",
"Sample ID":"ID_32",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_32.RAW","RAW_FILE_NAME":"ID_32.mzXML"}
},
{
"Subject ID":"Hc.CoV.204",
"Sample ID":"ID_33",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_33.RAW","RAW_FILE_NAME":"ID_33.mzXML"}
},
{
"Subject ID":"HC.CoV. 065 (O C S)",
"Sample ID":"ID_34",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_34.RAW","RAW_FILE_NAME":"ID_34.mzXML"}
},
{
"Subject ID":"Hc.CoV.313",
"Sample ID":"ID_35",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_35.RAW","RAW_FILE_NAME":"ID_35.mzXML"}
},
{
"Subject ID":"Hc.CoV.118 (CJP)",
"Sample ID":"ID_36",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_36.RAW","RAW_FILE_NAME":"ID_36.mzXML"}
},
{
"Subject ID":"NHc.CoV.020",
"Sample ID":"ID_37",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_37.RAW","RAW_FILE_NAME":"ID_37.mzXML"}
},
{
"Subject ID":"HC.CoV. 064 (J M S)",
"Sample ID":"ID_38",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_38.RAW","RAW_FILE_NAME":"ID_38.mzXML"}
},
{
"Subject ID":"Hc.CoV.291",
"Sample ID":"ID_39",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_39.RAW","RAW_FILE_NAME":"ID_39.mzXML"}
},
{
"Subject ID":"Hc.CoV.197",
"Sample ID":"ID_40",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_40.RAW","RAW_FILE_NAME":"ID_40.mzXML"}
},
{
"Subject ID":"Hc.CoV.312",
"Sample ID":"ID_41",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_41.RAW","RAW_FILE_NAME":"ID_41.mzXML"}
},
{
"Subject ID":"Hc.CoV.272",
"Sample ID":"ID_42",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_42.RAW","RAW_FILE_NAME":"ID_42.mzXML"}
},
{
"Subject ID":"Hc.CoV.296",
"Sample ID":"ID_43",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_43.RAW","RAW_FILE_NAME":"ID_43.mzXML"}
},
{
"Subject ID":"HC.CoV. 050 (G E S)",
"Sample ID":"ID_44",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_44.RAW","RAW_FILE_NAME":"ID_44.mzXML"}
},
{
"Subject ID":"HC.CoV. 054 (Z R R L)",
"Sample ID":"ID_45",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_45.RAW","RAW_FILE_NAME":"ID_45.mzXML"}
},
{
"Subject ID":"NHc.CoV.024",
"Sample ID":"ID_46",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_46.RAW","RAW_FILE_NAME":"ID_46.mzXML"}
},
{
"Subject ID":"NHc.CoV.035",
"Sample ID":"ID_47",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_47.RAW","RAW_FILE_NAME":"ID_47.mzXML"}
},
{
"Subject ID":"NHc.CoV.032",
"Sample ID":"ID_48",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_48.RAW","RAW_FILE_NAME":"ID_48.mzXML"}
},
{
"Subject ID":"Hc.CoV.227",
"Sample ID":"ID_49",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_49.RAW","RAW_FILE_NAME":"ID_49.mzXML"}
},
{
"Subject ID":"Hc.CoV.167",
"Sample ID":"ID_50",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_50.RAW","RAW_FILE_NAME":"ID_50.mzXML"}
},
{
"Subject ID":"NHc.CoV.009",
"Sample ID":"ID_51",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_51.RAW","RAW_FILE_NAME":"ID_51.mzXML"}
},
{
"Subject ID":"NHc.CoV.042",
"Sample ID":"ID_52",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_52.RAW","RAW_FILE_NAME":"ID_52.mzXML"}
},
{
"Subject ID":"Hc.CoV.125(S N A)",
"Sample ID":"ID_53",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_53.RAW","RAW_FILE_NAME":"ID_53.mzXML"}
},
{
"Subject ID":"Hc.CoV.273",
"Sample ID":"ID_54",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_54.RAW","RAW_FILE_NAME":"ID_54.mzXML"}
},
{
"Subject ID":"NHc.CoV.036_01",
"Sample ID":"ID_55",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_55.RAW","RAW_FILE_NAME":"ID_55.mzXML"}
},
{
"Subject ID":"NHc.CoV.036_02",
"Sample ID":"ID_56",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_56.RAW","RAW_FILE_NAME":"ID_56.mzXML"}
},
{
"Subject ID":"NHc.CoV.036_03",
"Sample ID":"ID_57",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_57.RAW","RAW_FILE_NAME":"ID_57.mzXML"}
},
{
"Subject ID":"NHc.CoV.046",
"Sample ID":"ID_58",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_58.RAW","RAW_FILE_NAME":"ID_58.mzXML"}
},
{
"Subject ID":"NHc.CoV.025",
"Sample ID":"ID_59",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_59.RAW","RAW_FILE_NAME":"ID_59.mzXML"}
},
{
"Subject ID":"HC.CoV. 032 (I A A)",
"Sample ID":"ID_60",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_60.RAW","RAW_FILE_NAME":"ID_60.mzXML"}
},
{
"Subject ID":"Hc.CoV.182",
"Sample ID":"ID_61",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_61.RAW","RAW_FILE_NAME":"ID_61.mzXML"}
},
{
"Subject ID":"Hc.CoV.220",
"Sample ID":"ID_62",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_62.RAW","RAW_FILE_NAME":"ID_62.mzXML"}
},
{
"Subject ID":"Hc.CoV.343",
"Sample ID":"ID_63",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_63.RAW","RAW_FILE_NAME":"ID_63.mzXML"}
},
{
"Subject ID":"HC.CoV. 020 (M A C S A)",
"Sample ID":"ID_67",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_67.RAW","RAW_FILE_NAME":"ID_67.mzXML"}
},
{
"Subject ID":"Hc.CoV.217",
"Sample ID":"ID_68",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_68.RAW","RAW_FILE_NAME":"ID_68.mzXML"}
},
{
"Subject ID":"NHc.CoV.038",
"Sample ID":"ID_69",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_69.RAW","RAW_FILE_NAME":"ID_69.mzXML"}
},
{
"Subject ID":"Hc.CoV.234",
"Sample ID":"ID_70",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_70.RAW","RAW_FILE_NAME":"ID_70.mzXML"}
},
{
"Subject ID":"Hc.CoV.267",
"Sample ID":"ID_71",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_71.RAW","RAW_FILE_NAME":"ID_71.mzXML"}
},
{
"Subject ID":"Hc.CoV.236",
"Sample ID":"ID_72",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_72.RAW","RAW_FILE_NAME":"ID_72.mzXML"}
},
{
"Subject ID":"Hc.CoV.173",
"Sample ID":"ID_73",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_73.RAW","RAW_FILE_NAME":"ID_73.mzXML"}
},
{
"Subject ID":"HC.CoV. 025 (R G N A)",
"Sample ID":"ID_74",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_74.RAW","RAW_FILE_NAME":"ID_74.mzXML"}
},
{
"Subject ID":"Hc.CoV.215",
"Sample ID":"ID_75",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_75.RAW","RAW_FILE_NAME":"ID_75.mzXML"}
},
{
"Subject ID":"Hc.CoV.238",
"Sample ID":"ID_76",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_76.RAW","RAW_FILE_NAME":"ID_76.mzXML"}
},
{
"Subject ID":"HC.CoV. 094 (M G M)",
"Sample ID":"ID_77",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_77.RAW","RAW_FILE_NAME":"ID_77.mzXML"}
},
{
"Subject ID":"Hc.CoV.222",
"Sample ID":"ID_78",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_78.RAW","RAW_FILE_NAME":"ID_78.mzXML"}
},
{
"Subject ID":"Hc.CoV.266",
"Sample ID":"ID_79",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_79.RAW","RAW_FILE_NAME":"ID_79.mzXML"}
},
{
"Subject ID":"HC.CoV. 036 (J C L)",
"Sample ID":"ID_80",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_80.RAW","RAW_FILE_NAME":"ID_80.mzXML"}
},
{
"Subject ID":"NHc.CoV.044",
"Sample ID":"ID_81",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_81.RAW","RAW_FILE_NAME":"ID_81.mzXML"}
},
{
"Subject ID":"NHc.CoV.044",
"Sample ID":"ID_82",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_82.RAW","RAW_FILE_NAME":"ID_82.mzXML"}
},
{
"Subject ID":"NHc.CoV.044",
"Sample ID":"ID_83",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_83.RAW","RAW_FILE_NAME":"ID_83.mzXML"}
},
{
"Subject ID":"NHc.CoV.043",
"Sample ID":"ID_84",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_84.RAW","RAW_FILE_NAME":"ID_84.mzXML"}
},
{
"Subject ID":"Hc.Cov.109 (J R N)",
"Sample ID":"ID_85",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_85.RAW","RAW_FILE_NAME":"ID_85.mzXML"}
},
{
"Subject ID":"Hc.CoV.104 (M S S)",
"Sample ID":"ID_86",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_86.RAW","RAW_FILE_NAME":"ID_86.mzXML"}
},
{
"Subject ID":"Hc.CoV.105 (S G R)",
"Sample ID":"ID_87",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_87.RAW","RAW_FILE_NAME":"ID_87.mzXML"}
},
{
"Subject ID":"HC.CoV. 103 (C S S)",
"Sample ID":"ID_88",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_88.RAW","RAW_FILE_NAME":"ID_88.mzXML"}
},
{
"Subject ID":"HC.CoV. 046 (E C)",
"Sample ID":"ID_89",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_89.RAW","RAW_FILE_NAME":"ID_89.mzXML"}
},
{
"Subject ID":"Hc.CoV.183",
"Sample ID":"ID_90",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_90.RAW","RAW_FILE_NAME":"ID_90.mzXML"}
},
{
"Subject ID":"Hc.CoV.163",
"Sample ID":"ID_91",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_91.RAW","RAW_FILE_NAME":"ID_91.mzXML"}
},
{
"Subject ID":"NHc.CoV.028",
"Sample ID":"ID_92",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_92.RAW","RAW_FILE_NAME":"ID_92.mzXML"}
},
{
"Subject ID":"Hc.CoV.154 (A C S)",
"Sample ID":"ID_93",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_93.RAW","RAW_FILE_NAME":"ID_93.mzXML"}
},
{
"Subject ID":"Hc.CoV.181",
"Sample ID":"ID_94",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_94.RAW","RAW_FILE_NAME":"ID_94.mzXML"}
},
{
"Subject ID":"Hc.CoV.149 (A F R)",
"Sample ID":"ID_95",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_95.RAW","RAW_FILE_NAME":"ID_95.mzXML"}
},
{
"Subject ID":"NHC.CoV.034",
"Sample ID":"ID_99",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_99.RAW","RAW_FILE_NAME":"ID_99.mzXML"}
},
{
"Subject ID":"NHC.CoV.034",
"Sample ID":"ID_100",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_100.RAW","RAW_FILE_NAME":"ID_100.mzXML"}
},
{
"Subject ID":"NHC.CoV.034",
"Sample ID":"ID_101",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_101.RAW","RAW_FILE_NAME":"ID_101.mzXML"}
},
{
"Subject ID":"Hc.CoV.108 (C A N C)",
"Sample ID":"ID_102",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_102.RAW","RAW_FILE_NAME":"ID_102.mzXML"}
},
{
"Subject ID":"Hc.CoV.314",
"Sample ID":"ID_103",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_103.RAW","RAW_FILE_NAME":"ID_103.mzXML"}
},
{
"Subject ID":"NHc.CoV.045",
"Sample ID":"ID_104",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_104.RAW","RAW_FILE_NAME":"ID_104.mzXML"}
},
{
"Subject ID":"Hc.CoV.112 (M M B A)",
"Sample ID":"ID_105",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_105.RAW","RAW_FILE_NAME":"ID_105.mzXML"}
},
{
"Subject ID":"Hc.CoV.126 (MDS)",
"Sample ID":"ID_106",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_106.RAW","RAW_FILE_NAME":"ID_106.mzXML"}
},
{
"Subject ID":"Hc.CoV.176",
"Sample ID":"ID_107",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_107.RAW","RAW_FILE_NAME":"ID_107.mzXML"}
},
{
"Subject ID":"HC.CoV. 151 (M H P R)",
"Sample ID":"ID_108",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_108.RAW","RAW_FILE_NAME":"ID_108.mzXML"}
},
{
"Subject ID":"Hc.CoV.148 (R P O)",
"Sample ID":"ID_109",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_109.RAW","RAW_FILE_NAME":"ID_109.mzXML"}
},
{
"Subject ID":"Hc.CoV.208",
"Sample ID":"ID_110",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_110.RAW","RAW_FILE_NAME":"ID_110.mzXML"}
},
{
"Subject ID":"HC.CoV. 027 (V B C)",
"Sample ID":"ID_111",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_111.RAW","RAW_FILE_NAME":"ID_111.mzXML"}
},
{
"Subject ID":"Hc.CoV.191",
"Sample ID":"ID_112",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_112.RAW","RAW_FILE_NAME":"ID_112.mzXML"}
},
{
"Subject ID":"Hc.CoV.216",
"Sample ID":"ID_113",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_113.RAW","RAW_FILE_NAME":"ID_113.mzXML"}
},
{
"Subject ID":"Hc.CoV.140 (M G R)",
"Sample ID":"ID_114",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_114.RAW","RAW_FILE_NAME":"ID_114.mzXML"}
},
{
"Subject ID":"Hc.CoV.117 (G P S)",
"Sample ID":"ID_115",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_115.RAW","RAW_FILE_NAME":"ID_115.mzXML"}
},
{
"Subject ID":"HC.CoV. 098 (J R R)",
"Sample ID":"ID_116",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_116.RAW","RAW_FILE_NAME":"ID_116.mzXML"}
},
{
"Subject ID":"Hc.CoV.207",
"Sample ID":"ID_117",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_117.RAW","RAW_FILE_NAME":"ID_117.mzXML"}
},
{
"Subject ID":"Hc.CoV.165",
"Sample ID":"ID_118",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_118.RAW","RAW_FILE_NAME":"ID_118.mzXML"}
},
{
"Subject ID":"Hc.CoV.138 (R A O)",
"Sample ID":"ID_119",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_119.RAW","RAW_FILE_NAME":"ID_119.mzXML"}
},
{
"Subject ID":"Hc.Cov.021",
"Sample ID":"ID_120",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_120.RAW","RAW_FILE_NAME":"ID_120.mzXML"}
},
{
"Subject ID":"Hc.CoV.121 (A J C)",
"Sample ID":"ID_124",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_124.RAW","RAW_FILE_NAME":"ID_124.mzXML"}
},
{
"Subject ID":"Hc.CoV.225",
"Sample ID":"ID_125",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_125.RAW","RAW_FILE_NAME":"ID_125.mzXML"}
},
{
"Subject ID":"Hc.CoV.106 (B C C)",
"Sample ID":"ID_126",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_126.RAW","RAW_FILE_NAME":"ID_126.mzXML"}
},
{
"Subject ID":"Hc.CoV.43",
"Sample ID":"ID_127",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_127.RAW","RAW_FILE_NAME":"ID_127.mzXML"}
},
{
"Subject ID":"Hc.CoV.137 (J E S S)",
"Sample ID":"ID_128",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_128.RAW","RAW_FILE_NAME":"ID_128.mzXML"}
},
{
"Subject ID":"Hc.CoV.130 (M F M S)",
"Sample ID":"ID_129",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_129.RAW","RAW_FILE_NAME":"ID_129.mzXML"}
},
{
"Subject ID":"Hc.CoV.161",
"Sample ID":"ID_130",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_130.RAW","RAW_FILE_NAME":"ID_130.mzXML"}
},
{
"Subject ID":"Hc.CoV.139 (S R C)",
"Sample ID":"ID_131",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_131.RAW","RAW_FILE_NAME":"ID_131.mzXML"}
},
{
"Subject ID":"Hc.CoV.246",
"Sample ID":"ID_132",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_132.RAW","RAW_FILE_NAME":"ID_132.mzXML"}
},
{
"Subject ID":"Hc.CoV.205",
"Sample ID":"ID_133",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_133.RAW","RAW_FILE_NAME":"ID_133.mzXML"}
},
{
"Subject ID":"HC.CoV270",
"Sample ID":"ID_134",
"Factors":{"Group":"Fatal"},
"Additional sample data":{"RAW_FILE_NAME":"ID_134.RAW","RAW_FILE_NAME":"ID_134.mzXML"}
},
{
"Subject ID":"Hc.CoV.226",
"Sample ID":"ID_138",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_138.RAW","RAW_FILE_NAME":"ID_138.mzXML"}
},
{
"Subject ID":"Hc.CoV.171",
"Sample ID":"ID_139",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_139.RAW","RAW_FILE_NAME":"ID_139.mzXML"}
},
{
"Subject ID":"Hc.CoV.230",
"Sample ID":"ID_140",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_140.RAW","RAW_FILE_NAME":"ID_140.mzXML"}
},
{
"Subject ID":"Hc.CoV.243",
"Sample ID":"ID_141",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_141.RAW","RAW_FILE_NAME":"ID_141.mzXML"}
},
{
"Subject ID":"Hc.CoV.242",
"Sample ID":"ID_142",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_142.RAW","RAW_FILE_NAME":"ID_142.mzXML"}
},
{
"Subject ID":"Hc.CoV.203",
"Sample ID":"ID_143",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_143.RAW","RAW_FILE_NAME":"ID_143.mzXML"}
},
{
"Subject ID":"Hc.CoV.229",
"Sample ID":"ID_144",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_144.RAW","RAW_FILE_NAME":"ID_144.mzXML"}
},
{
"Subject ID":"Hc.CoV.233",
"Sample ID":"ID_145",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_145.RAW","RAW_FILE_NAME":"ID_145.mzXML"}
},
{
"Subject ID":"Hc.CoV.298",
"Sample ID":"ID_146",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_146.RAW","RAW_FILE_NAME":"ID_146.mzXML"}
},
{
"Subject ID":"Hc.CoV.300",
"Sample ID":"ID_147",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_147.RAW","RAW_FILE_NAME":"ID_147.mzXML"}
},
{
"Subject ID":"Hc.CoV.329",
"Sample ID":"ID_148",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_148.RAW","RAW_FILE_NAME":"ID_148.mzXML"}
},
{
"Subject ID":"Hc.CoV.305",
"Sample ID":"ID_149",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_149.RAW","RAW_FILE_NAME":"ID_149.mzXML"}
},
{
"Subject ID":"Hc.CoV.301",
"Sample ID":"ID_150",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_150.RAW","RAW_FILE_NAME":"ID_150.mzXML"}
},
{
"Subject ID":"Hc.CoV.231",
"Sample ID":"ID_151",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_151.RAW","RAW_FILE_NAME":"ID_151.mzXML"}
},
{
"Subject ID":"Hc.CoV.026",
"Sample ID":"ID_152",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_152.RAW","RAW_FILE_NAME":"ID_152.mzXML"}
},
{
"Subject ID":"Hc.CoV.308",
"Sample ID":"ID_153",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_153.RAW","RAW_FILE_NAME":"ID_153.mzXML"}
},
{
"Subject ID":"Hc.CoV.363",
"Sample ID":"ID_154",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_154.RAW","RAW_FILE_NAME":"ID_154.mzXML"}
},
{
"Subject ID":"Hc.CoV.332",
"Sample ID":"ID_155",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_155.RAW","RAW_FILE_NAME":"ID_155.mzXML"}
},
{
"Subject ID":"Hc.CoV.333",
"Sample ID":"ID_156",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_156.RAW","RAW_FILE_NAME":"ID_156.mzXML"}
},
{
"Subject ID":"Hc.CoV.022",
"Sample ID":"ID_157",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_157.RAW","RAW_FILE_NAME":"ID_157.mzXML"}
},
{
"Subject ID":"Hc.CoV.022",
"Sample ID":"ID_158",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_158.RAW","RAW_FILE_NAME":"ID_158.mzXML"}
},
{
"Subject ID":"Hc.CoV.022",
"Sample ID":"ID_159",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_159.RAW","RAW_FILE_NAME":"ID_159.mzXML"}
},
{
"Subject ID":"Hc.CoV.185",
"Sample ID":"ID_163",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_163.RAW","RAW_FILE_NAME":"ID_163.mzXML"}
},
{
"Subject ID":"NHc.CoV.008",
"Sample ID":"ID_164",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_164.RAW","RAW_FILE_NAME":"ID_164.mzXML"}
},
{
"Subject ID":"NHc.CoV.039",
"Sample ID":"ID_165",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_165.RAW","RAW_FILE_NAME":"ID_165.mzXML"}
},
{
"Subject ID":"NHc.CoV.040",
"Sample ID":"ID_166",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_166.RAW","RAW_FILE_NAME":"ID_166.mzXML"}
},
{
"Subject ID":"Hc.CoV.211",
"Sample ID":"ID_167",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_167.RAW","RAW_FILE_NAME":"ID_167.mzXML"}
},
{
"Subject ID":"Hc.CoV.129 (S R F)",
"Sample ID":"ID_168",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_168.RAW","RAW_FILE_NAME":"ID_168.mzXML"}
},
{
"Subject ID":"NHc.CoV.006",
"Sample ID":"ID_169",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_169.RAW","RAW_FILE_NAME":"ID_169.mzXML"}
},
{
"Subject ID":"Hc.CoV.166 (N R S)",
"Sample ID":"ID_170",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_170.RAW","RAW_FILE_NAME":"ID_170.mzXML"}
},
{
"Subject ID":"Hc.CoV.240",
"Sample ID":"ID_171",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_171.RAW","RAW_FILE_NAME":"ID_171.mzXML"}
},
{
"Subject ID":"Hc.CoV.241",
"Sample ID":"ID_172",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_172.RAW","RAW_FILE_NAME":"ID_172.mzXML"}
},
{
"Subject ID":"NHc.CoV.030",
"Sample ID":"ID_173",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_173.RAW","RAW_FILE_NAME":"ID_173.mzXML"}
},
{
"Subject ID":"NHc.CoV.023",
"Sample ID":"ID_174",
"Factors":{"Group":"Severe"},
"Additional sample data":{"RAW_FILE_NAME":"ID_174.RAW","RAW_FILE_NAME":"ID_174.mzXML"}
},
{
"Subject ID":"NHc.CoV.031",
"Sample ID":"ID_175",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_175.RAW","RAW_FILE_NAME":"ID_175.mzXML"}
},
{
"Subject ID":"Hc.CoV.237",
"Sample ID":"ID_176",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_176.RAW","RAW_FILE_NAME":"ID_176.mzXML"}
},
{
"Subject ID":"NHc.CoV.005",
"Sample ID":"ID_177",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_177.RAW","RAW_FILE_NAME":"ID_177.mzXML"}
},
{
"Subject ID":"Hc.CoV.235",
"Sample ID":"ID_178",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_178.RAW","RAW_FILE_NAME":"ID_178.mzXML"}
},
{
"Subject ID":"Hc.CoV.328",
"Sample ID":"ID_179",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_179.RAW","RAW_FILE_NAME":"ID_179.mzXML"}
},
{
"Subject ID":"NHc.CoV.033",
"Sample ID":"ID_180",
"Factors":{"Group":"Moderated"},
"Additional sample data":{"RAW_FILE_NAME":"ID_180.RAW","RAW_FILE_NAME":"ID_180.mzXML"}
},
{
"Subject ID":"NHc.CoV.033",
"Sample ID":"ID_181",
"Factors":{"Group":"Mild"},
"Additional sample data":{"RAW_FILE_NAME":"ID_181.RAW","RAW_FILE_NAME":"ID_181.mzXML"}
},
{
"Subject ID":"HC.CoV. 033 (D D",
"Sample ID":"ID_182",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_182.RAW","RAW_FILE_NAME":"ID_182.mzXML"}
},
{
"Subject ID":"Hc.CoV.306",
"Sample ID":"ID_186",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_186.RAW","RAW_FILE_NAME":"ID_186.mzXML"}
},
{
"Subject ID":"Hc.CoV.349",
"Sample ID":"ID_187",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_187.RAW","RAW_FILE_NAME":"ID_187.mzXML"}
},
{
"Subject ID":"Hc.CoV.304",
"Sample ID":"ID_188",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_188.RAW","RAW_FILE_NAME":"ID_188.mzXML"}
},
{
"Subject ID":"Hc.CoV.261",
"Sample ID":"ID_189",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_189.RAW","RAW_FILE_NAME":"ID_189.mzXML"}
},
{
"Subject ID":"Hc.CoV.350",
"Sample ID":"ID_190",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_190.RAW","RAW_FILE_NAME":"ID_190.mzXML"}
},
{
"Subject ID":"Hc.CoV.076",
"Sample ID":"ID_191",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_191.RAW","RAW_FILE_NAME":"ID_191.mzXML"}
},
{
"Subject ID":"Hc.CoV.040",
"Sample ID":"ID_192",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_192.RAW","RAW_FILE_NAME":"ID_192.mzXML"}
},
{
"Subject ID":"Hc.CoV.346",
"Sample ID":"ID_193",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_193.RAW","RAW_FILE_NAME":"ID_193.mzXML"}
},
{
"Subject ID":"Hc.CoV.326",
"Sample ID":"ID_194",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_194.RAW","RAW_FILE_NAME":"ID_194.mzXML"}
},
{
"Subject ID":"Hc.CoV.348",
"Sample ID":"ID_195",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_195.RAW","RAW_FILE_NAME":"ID_195.mzXML"}
},
{
"Subject ID":"Hc.CoV.338",
"Sample ID":"ID_196",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_196.RAW","RAW_FILE_NAME":"ID_196.mzXML"}
},
{
"Subject ID":"Hc.CoV.344",
"Sample ID":"ID_197",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_197.RAW","RAW_FILE_NAME":"ID_197.mzXML"}
},
{
"Subject ID":"Hc.CoV.340",
"Sample ID":"ID_198",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_198.RAW","RAW_FILE_NAME":"ID_198.mzXML"}
},
{
"Subject ID":"Hc.CoV.353",
"Sample ID":"ID_199",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_199.RAW","RAW_FILE_NAME":"ID_199.mzXML"}
},
{
"Subject ID":"Hc.CoV.351",
"Sample ID":"ID_200",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_200.RAW","RAW_FILE_NAME":"ID_200.mzXML"}
},
{
"Subject ID":"Hc.CoV.356",
"Sample ID":"ID_201",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_201.RAW","RAW_FILE_NAME":"ID_201.mzXML"}
},
{
"Subject ID":"Hc.CoV.342",
"Sample ID":"ID_202",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_202.RAW","RAW_FILE_NAME":"ID_202.mzXML"}
},
{
"Subject ID":"Hc.CoV.343",
"Sample ID":"ID_203",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_203.RAW","RAW_FILE_NAME":"ID_203.mzXML"}
},
{
"Subject ID":"Hc.CoV.355",
"Sample ID":"ID_204",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_204.RAW","RAW_FILE_NAME":"ID_204.mzXML"}
},
{
"Subject ID":"Hc.CoV.051",
"Sample ID":"ID_205",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_205.RAW","RAW_FILE_NAME":"ID_205.mzXML"}
},
{
"Subject ID":"Hc.CoV.085",
"Sample ID":"ID_206",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_206.RAW","RAW_FILE_NAME":"ID_206.mzXML"}
},
{
"Subject ID":"Hc.CoV.052",
"Sample ID":"ID_207",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_207.RAW","RAW_FILE_NAME":"ID_207.mzXML"}
},
{
"Subject ID":"Hc.CoV.082",
"Sample ID":"ID_208",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_208.RAW","RAW_FILE_NAME":"ID_208.mzXML"}
},
{
"Subject ID":"Hc.CoV.345",
"Sample ID":"ID_209",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_209.RAW","RAW_FILE_NAME":"ID_209.mzXML"}
},
{
"Subject ID":"Hc.CoV.345",
"Sample ID":"ID_210",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_210.RAW","RAW_FILE_NAME":"ID_210.mzXML"}
},
{
"Subject ID":"Hc.CoV.345",
"Sample ID":"ID_211",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_211.RAW","RAW_FILE_NAME":"ID_211.mzXML"}
},
{
"Subject ID":"Hc.CoV.347",
"Sample ID":"ID_212",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_212.RAW","RAW_FILE_NAME":"ID_212.mzXML"}
},
{
"Subject ID":"HC.CoV. 089",
"Sample ID":"ID_213",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_213.RAW","RAW_FILE_NAME":"ID_213.mzXML"}
},
{
"Subject ID":"Hc.CoV.303",
"Sample ID":"ID_214",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_214.RAW","RAW_FILE_NAME":"ID_214.mzXML"}
},
{
"Subject ID":"HC.CoV. 093",
"Sample ID":"ID_215",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_215.RAW","RAW_FILE_NAME":"ID_215.mzXML"}
},
{
"Subject ID":"Hc.CoV.129 (S R F)",
"Sample ID":"ID_218",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_218.RAW","RAW_FILE_NAME":"ID_218.mzXML"}
},
{
"Subject ID":"Hc.CoV.185",
"Sample ID":"ID_219",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_219.RAW","RAW_FILE_NAME":"ID_219.mzXML"}
},
{
"Subject ID":"Hc.CoV.237",
"Sample ID":"ID_220",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_220.RAW","RAW_FILE_NAME":"ID_220.mzXML"}
},
{
"Subject ID":"Hc.CoV.240",
"Sample ID":"ID_221",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_221.RAW","RAW_FILE_NAME":"ID_221.mzXML"}
},
{
"Subject ID":"Hc.CoV.241",
"Sample ID":"ID_222",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_222.RAW","RAW_FILE_NAME":"ID_222.mzXML"}
},
{
"Subject ID":"Hc.CoV.166 (N R S)",
"Sample ID":"ID_223",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_223.RAW","RAW_FILE_NAME":"ID_223.mzXML"}
},
{
"Subject ID":"Hc.CoV.154 (A C S)",
"Sample ID":"ID_224",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_224.RAW","RAW_FILE_NAME":"ID_224.mzXML"}
},
{
"Subject ID":"Hc.CoV.163 (N R S)",
"Sample ID":"ID_225",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_225.RAW","RAW_FILE_NAME":"ID_225.mzXML"}
},
{
"Subject ID":"HC.CoV. 036 (J C L)",
"Sample ID":"ID_226",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_226.RAW","RAW_FILE_NAME":"ID_226.mzXML"}
},
{
"Subject ID":"Hc.CoV.105 (S G R)",
"Sample ID":"ID_227",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_227.RAW","RAW_FILE_NAME":"ID_227.mzXML"}
},
{
"Subject ID":"HC.CoV. 065 (O C S)",
"Sample ID":"ID_228",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_228.RAW","RAW_FILE_NAME":"ID_228.mzXML"}
},
{
"Subject ID":"Hc.CoV.125(S N A)",
"Sample ID":"ID_229",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_229.RAW","RAW_FILE_NAME":"ID_229.mzXML"}
},
{
"Subject ID":"HC.CoV. 050 (G E S)",
"Sample ID":"ID_230",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_230.RAW","RAW_FILE_NAME":"ID_230.mzXML"}
},
{
"Subject ID":"HC.CoV.118",
"Sample ID":"ID_231",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_231.RAW","RAW_FILE_NAME":"ID_231.mzXML"}
},
{
"Subject ID":"HC.CoV. 064 (J M S)",
"Sample ID":"ID_232",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_232.RAW","RAW_FILE_NAME":"ID_232.mzXML"}
},
{
"Subject ID":"HC.CoV. 008 (B A S)",
"Sample ID":"ID_233",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_233.RAW","RAW_FILE_NAME":"ID_233.mzXML"}
},
{
"Subject ID":"Hc.CoV.157 (N M)",
"Sample ID":"ID_234",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_234.RAW","RAW_FILE_NAME":"ID_234.mzXML"}
},
{
"Subject ID":"Hc.CoV.164",
"Sample ID":"ID_235",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_235.RAW","RAW_FILE_NAME":"ID_235.mzXML"}
},
{
"Subject ID":"Hc.CoV.127",
"Sample ID":"ID_236",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_236.RAW","RAW_FILE_NAME":"ID_236.mzXML"}
},
{
"Subject ID":"NHC.CoV.047",
"Sample ID":"ID_237",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_237.RAW","RAW_FILE_NAME":"ID_237.mzXML"}
},
{
"Subject ID":"NHC.CoV.047",
"Sample ID":"ID_238",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_238.RAW","RAW_FILE_NAME":"ID_238.mzXML"}
},
{
"Subject ID":"NHC.CoV.047",
"Sample ID":"ID_239",
"Factors":{"Group":"Recovered"},
"Additional sample data":{"RAW_FILE_NAME":"ID_239.RAW","RAW_FILE_NAME":"ID_239.mzXML"}
},
{
"Subject ID":"HC.CoV. 045",
"Sample ID":"ID_240",
"Factors":{"Group":"Control donor"},
"Additional sample data":{"RAW_FILE_NAME":"ID_240.RAW","RAW_FILE_NAME":"ID_240.mzXML"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Individuals with COVID-19 were admitted to the Hospital das Clínicas and Hospital das Clínicas de Campanha or recruited at the Laboratório Profª Margarida Dobler Komma at the Federal University of Goiás, Goiânia, Brazil between June 2020 to February 2021, before vaccination rollout. Blood samples were collected in EDTA tubes from 150 individuals who had confirmed SARS-CoV-2 infection by RT-qPCR test from nasopharyngeal swabs or by serological assays to detect specific IgM/IgG antibodies (Eco diagnostics); and control donors (n=27), who were negative for SARS-CoV-2 infection confirmed by RT-qPCR from nasopharyngeal swabs and serological IgM/IgG tests.","SAMPLE_TYPE":"Blood (plasma)"},

"TREATMENT":{"TREATMENT_SUMMARY":"The criteria defined on COVID-19 Treatment Guidelines (National Institute of Health, USA) and World Health Organization [21,22] were used to stratify individuals with COVID-19 into mild disease (individuals presenting various signs and symptoms without shortness of breath, dyspnea, or abnormal chest imaging), moderate disease (individuals presenting radiologically confirmed pneumonitis, hospitalization and oxygen therapy), severe disease (dyspnea, respiratory frequency ≥30 breaths/min, saturation of oxygen [SpO2] ≤ 93%, and/or lung infiltrates >50% within 24 to 48 hours, including individuals that required monitoring and treatment in Intensive Care Unit and mechanical ventilation), or fatal COVID-19."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"For metabolomics analyses, cold acetonitrile was added to plasma samples (2:1, v/v) vortexed and centrifuged (10 min, 10000 rpm at 4 °C) for protein precipitation. Stable isotopes caffeine-¹³C3, tyrosine-15N and progesterone-d9 were used as internal standards."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"The binary mobile phases were water 0.5% formic acid with 5 mM of ammonium formate (A), and acetonitrile (B). Their gradient elution started with 20% (B) for 5 min, then linearly increased to 100% (B) in 30 min and kept constant for 8 min in 100% (B). The eluent was restored to the initial conditions in 4 minutes to re-equilibrate the column and held for the remaining 8 minutes. The flow rate was kept at 0.5 mL min-1. The injection volume for analysis was 3 μL, and the column temperature was set at 35 °C.","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Agilent 1220 Infinity","COLUMN_NAME":"Agilent Zorbax Eclipse Plus C18 column 4.6 x 150 mm 3.5 μm"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"The electrospray ionization was operating with the following settings: spray voltage 3.5 kV; capillary temperature: 269 °C; S-lens RF level 50 V; sheath gas flow rate at 53 L min-1; aux gas flow rate at 14 L min-1; sweep gas flow rate 3 L min-1. The high-resolution mass-spectrometry was obtained under full MS/dd-MS2 mode. The mass range in the full MS scanning experiments was m/z 80-1200. The max IT was set at 200 ms, and AGC target was set at 1 x 106. For fragmentation acquisition, the top 5 (TopN, 5, loop count 5) most abundant precursors were sequentially transferred into the C-Trap (AGC target 1 x 105; max IT 50 ms) for collision. The collision energy for target analytes was 20, 30 and 35 eV. Resolving power was set at 140,000 and 70,000 for full MS and dd-MS2 acquisitions, respectively. Proteowizard software was used to convert .raw files into mzXML format and apLCMS software was used to perform peak deconvolution and detection, to filter noise, to align mass-to-charge ratio (m/z) and retention time and to quantify metabolite features, which are defined by a specific m/z, retention time and intensity values for each sample.","MS_RESULTS_FILE":"ST002291_AN003743_Results.txt UNITS:peak area Has m/z:Yes Has RT:Yes RT units:Seconds"}

}