#METABOLOMICS WORKBENCH araskind_20150610_9248451_mwtab.txt DATATRACK_ID:301 STUDY_ID:ST000245 ANALYSIS_ID:AN000383 PROJECT_ID:PR000198 VERSION 1 CREATED_ON 2016-09-17 #PROJECT PR:PROJECT_TITLE Metabolism of muscle proteins in type I diabetic mice PR:PROJECT_SUMMARY Comparison of Short Chain Acyl-carnitines in treated diabetic, untreated PR:PROJECT_SUMMARY and control mouse soleus muscle PR:INSTITUTE Mayo Clinic PR:DEPARTMENT Endocrine Research PR:LABORATORY Nair Lab PR:LAST_NAME Nair PR:FIRST_NAME Sree PR:ADDRESS Rochester, MN PR:EMAIL nair.sree@mayo.edu PR:PHONE 507-255-2969 #STUDY ST:STUDY_TITLE Acyl-Carnitine Analysis in mouse soleus muscle ST:STUDY_SUMMARY Comparison of Short Chain Acyl-carnitines in treated diabetic, untreated ST:STUDY_SUMMARY and control mouse soleus muscle ST:INSTITUTE University of Michigan ST:DEPARTMENT Biomedical Research Core Facilities ST:LABORATORY Metabolomics core ST:LAST_NAME Kachman ST:FIRST_NAME Maureen ST:ADDRESS 6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714 ST:EMAIL mkachman@umich.edu ST:PHONE - ST:NUM_GROUPS 3 ST:TOTAL_SUBJECTS 19 #SUBJECT SU:SUBJECT_TYPE Animal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 SU:SPECIES_GROUP Mammal #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS SU0004260 S00015067 status:control SUBJECT_SAMPLE_FACTORS SU0004261 S00015068 status:control SUBJECT_SAMPLE_FACTORS SU0004262 S00015069 status:control SUBJECT_SAMPLE_FACTORS SU0004263 S00015070 status:control SUBJECT_SAMPLE_FACTORS SU0004264 S00015071 status:control SUBJECT_SAMPLE_FACTORS SU0004265 S00015072 status:control SUBJECT_SAMPLE_FACTORS SU0004266 S00015073 status:control SUBJECT_SAMPLE_FACTORS SU0004267 S00015074 status:Treated diabetic SUBJECT_SAMPLE_FACTORS SU0004268 S00015075 status:Treated diabetic SUBJECT_SAMPLE_FACTORS SU0004269 S00015076 status:Treated diabetic SUBJECT_SAMPLE_FACTORS SU0004270 S00015077 status:Treated diabetic SUBJECT_SAMPLE_FACTORS SU0004271 S00015078 status:Treated diabetic SUBJECT_SAMPLE_FACTORS SU0004272 S00015079 status:untreated diabetic SUBJECT_SAMPLE_FACTORS SU0004273 S00015080 status:untreated diabetic SUBJECT_SAMPLE_FACTORS SU0004274 S00015081 status:untreated diabetic SUBJECT_SAMPLE_FACTORS SU0004275 S00015082 status:untreated diabetic SUBJECT_SAMPLE_FACTORS SU0004276 S00015083 status:untreated diabetic SUBJECT_SAMPLE_FACTORS SU0004277 S00015084 status:untreated diabetic SUBJECT_SAMPLE_FACTORS SU0004278 S00015085 status:untreated diabetic #COLLECTION CO:COLLECTION_SUMMARY - CO:SAMPLE_TYPE Muscles #TREATMENT TR:TREATMENT_SUMMARY - #SAMPLEPREP SP:SAMPLEPREP_SUMMARY - SP:SAMPLEPREP_PROTOCOL_FILENAME Acyl-carnitines_analysis_protocol-CR-MK-20150528.docx #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Agilent 1200 CH:COLUMN_NAME Waters Acquity HSS T3 (50 x 2.1mm, 1.8um) CH:METHODS_ID AQM050 CH:METHODS_FILENAME QM-004-Xbridg2mm_ACar+_MRM-Insert.m.zip #ANALYSIS AN:ANALYSIS_TYPE MS AN:LABORATORY_NAME MRC2 (University of Michigan) AN:ACQUISITION_PARAMETERS_FILE QM-004-Xbridg2mm_ACar+_MRM-Insert.m.zip AN:PROCESSING_PARAMETERS_FILE EX00315-acyl-carnitines-quant.m.zip #MS MS:MS_COMMENTS - MS:INSTRUMENT_NAME Agilent 6490 QQQ MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE POSITIVE #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS pmol/mg tissue MS_METABOLITE_DATA_START Samples S00015067 S00015068 S00015070 S00015071 S00015072 S00015073 S00015074 S00015075 S00015076 S00015077 S00015078 S00015079 S00015081 S00015082 S00015083 S00015084 S00015085 Factors status:control status:control status:control status:control status:control status:control status:Treated diabetic status:Treated diabetic status:Treated diabetic status:Treated diabetic status:Treated diabetic status:untreated diabetic status:untreated diabetic status:untreated diabetic status:untreated diabetic status:untreated diabetic status:untreated diabetic 3-hydroxylauroylcarnitine 0.0002 0.0000 0.0002 0.0003 0.0004 0.0001 0.0006 0.0103 0.0002 0.0007 0.0003 0.0001 0.0000 0.0000 0.0002 0.0582 0.0615 3-Hydroxylinoleoylcarnitine 0.1478 0.4369 0.2336 0.4417 0.7451 0.1825 0.6872 1.1109 0.5990 0.5111 0.9401 0.2862 0.9023 0.2508 0.5497 0.3298 0.2158 3-hydroxymyristoylcarnitine 0.0389 0.0678 0.0654 0.0885 0.1777 0.0266 0.1190 0.2703 0.0553 0.1068 0.1219 0.1012 0.3247 0.1206 0.1952 0.0888 0.1112 3-Hydroxypalmitoylcarnitine 0.0016 0.0037 0.0025 0.0037 0.0102 0.0015 0.0063 0.0136 0.0041 0.0045 0.0059 0.0048 0.0095 0.0033 0.0098 0.0071 0.0032 Acetylcarnitine 107.2794 109.9590 166.9060 113.3923 143.6717 89.5402 114.8338 109.3963 84.2060 148.9747 159.0289 230.9135 294.0512 206.8433 394.1840 360.1519 147.5054 arachidonoylcarnitine 0.0333 0.1005 0.1168 0.0909 0.1268 0.0585 0.1096 0.1675 0.1436 0.1983 0.1059 0.0852 0.2401 0.1719 0.1531 0.0899 0.1094 butyrylcarnitine 3.2046 4.4962 4.0153 1.7713 15.5363 2.6298 8.2220 16.0830 6.7678 6.9494 7.8913 7.0221 13.8863 5.7767 13.3849 8.6608 5.7131 Decanoylcarnitine 0.0655 0.3344 0.3919 0.1251 1.1506 0.2568 0.5718 1.3918 0.6198 0.8837 0.9634 0.4737 0.9968 0.6076 0.7034 0.4321 0.4120 decenoylcarnitine 0.0260 0.2564 0.1580 0.0284 0.4801 0.1733 0.4773 0.8396 0.5387 0.5201 0.5857 0.2324 0.4273 0.2809 0.2787 0.2336 0.1119 Dodecenoylcarnitine 0.0229 0.1207 0.1181 0.0439 0.3435 0.0725 0.1875 0.5111 0.2071 0.2634 0.3609 0.1131 0.3607 0.1665 0.2206 0.1437 0.1209 Glutarylcarnitine 0.0581 0.0552 0.0676 0.0419 0.3122 0.0305 0.1459 0.2263 0.1004 0.1205 0.1906 0.1213 0.1998 0.1545 0.2831 0.2517 0.1261 Hexanoylcarnitine 0.2319 1.1715 1.3623 0.6770 4.5567 0.9469 2.2613 7.7782 2.6063 3.7057 2.9263 1.5965 3.0760 1.9346 2.1864 1.3317 1.5027 icosadienoylcarnitine 0.1527 0.7366 0.2935 0.5477 1.3943 0.1855 0.5858 2.7290 2.0964 0.4714 3.4048 0.4762 0.8284 0.3128 1.1228 0.4655 0.1966 Icosanoylcarnitine icosatrienoylcarnitine 0.0124 0.0592 0.0408 0.0526 0.0784 0.0164 0.0638 0.1362 0.1921 0.0814 0.2708 0.0406 0.0995 0.0526 0.0995 0.0385 0.0243 icoseneoylcarnitine 0.1318 0.4842 0.2556 0.6581 1.1046 0.1000 0.4199 1.3170 1.0834 0.3795 1.4901 0.3734 0.7140 0.3822 0.6949 0.2151 0.2426 isovalerylcarnitine 0.2518 0.2736 0.2645 0.1528 2.3170 0.5505 1.3497 2.7155 0.6101 0.4531 0.8265 0.4296 0.5627 0.5738 0.8530 0.7274 0.3624 lauroylcarnitine 0.0449 0.3461 0.3615 0.1999 1.0550 0.1890 0.4626 1.6523 0.7588 0.8098 0.8783 0.5084 1.4746 0.6530 0.6961 0.3458 0.5197 L-Carnitine 256.2252 174.3435 313.3616 193.1498 194.4122 275.7497 501.1227 261.2026 226.5943 499.3420 260.8330 354.8385 547.1150 673.9478 650.4375 653.8281 387.6479 Linoelaidyl carnitine 0.2297 4.1237 3.6459 2.9795 8.8434 3.5840 8.9993 22.0615 20.9990 6.2049 22.4761 1.7973 5.7598 2.7221 2.7037 2.5200 1.4212 myristoylcarnitine 0.1433 1.3672 1.3247 1.1023 3.1599 0.7123 2.1194 5.1046 3.5393 2.6616 3.6061 1.5988 5.6129 2.0811 2.1633 1.0774 1.4990 octanoylcarnitine 0.0506 0.3581 0.4021 0.1453 0.9687 0.2883 0.6473 1.7931 0.8610 1.0160 0.9895 0.4617 0.9094 0.5903 0.6504 0.3968 0.4166 Octenoylcarnitine 0.0691 0.1735 0.2443 0.1386 0.3453 0.2703 0.7390 0.4307 0.5188 0.7745 0.6569 0.3058 0.3812 0.4546 0.3752 0.4295 0.2621 Oleoylcarnitine 0.6572 5.7690 5.6176 9.7825 12.8779 4.2673 10.9204 23.6733 21.9608 9.5591 23.2925 3.1317 10.5314 4.6259 4.7628 3.6448 2.8133 Palmitoleylcarnitine 0.0728 0.9032 0.7637 0.6823 1.8901 0.4565 1.3713 3.6429 2.9257 1.4383 2.7769 0.6125 2.5991 0.7628 0.9912 0.5420 0.5489 palmitoylcarnitine 0.3995 3.3749 3.1395 5.4772 8.5737 2.2938 6.9842 14.4471 16.5470 6.3445 15.6988 2.9644 10.4619 4.9069 3.9029 2.3081 2.4840 propionylcarnitine 2.2783 2.0503 2.2779 0.9438 6.9644 2.9670 3.4938 4.7587 1.8858 3.9501 4.1635 4.9262 3.0737 7.1471 8.3920 8.5474 3.8547 Stearoylcarnitine 0.4749 1.9146 1.3699 3.1650 5.6532 1.6388 6.4441 7.7372 12.1866 4.0740 10.8711 1.9527 4.1018 3.6211 2.8200 1.2421 1.0920 Tetradecadiencarnitine 0.0566 0.7740 0.5778 0.1276 1.2657 0.4159 1.1097 2.6014 1.8554 1.3638 2.0896 0.4604 1.1789 0.6375 0.6731 0.5519 0.4299 Tetradecenoylcarnitine 0.0971 1.1502 0.9870 0.4880 2.5956 0.6392 1.4778 4.2647 2.4997 2.4099 2.5054 0.9303 2.8096 1.1011 1.3420 0.8174 0.9899 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name moverz_quant ri ri_type pubchem_id inchi_key kegg_id other_id other_id_type 3-hydroxylauroylcarnitine 71464535 C12-OH UM_Target_ID 3-Hydroxylinoleoylcarnitine 78076335 C18:2-OH UM_Target_ID 3-hydroxymyristoylcarnitine 71464541 C14-OH UM_Target_ID 3-Hydroxypalmitoylcarnitine 71464553 C16-OH UM_Target_ID Acetylcarnitine 1 C02571 C2 UM_Target_ID arachidonoylcarnitine 53477832 C20:4 UM_Target_ID butyrylcarnitine 213144 C02862 C4 UM_Target_ID Decanoylcarnitine 11953821 C03299 C10:0 UM_Target_ID decenoylcarnitine 54074509 C10:1 UM_Target_ID Dodecenoylcarnitine 53481671 C12:1 UM_Target_ID Glutarylcarnitine 53481622 C5:0-DC UM_Target_ID Hexanoylcarnitine 6426853 C6:0 UM_Target_ID icosadienoylcarnitine 71464509 C20:2 UM_Target_ID Icosanoylcarnitine 53477833 C20 UM_Target_ID icosatrienoylcarnitine C20:3 UM_Target_ID icoseneoylcarnitine 71464507 C20:1 UM_Target_ID isovalerylcarnitine 6426851 C5:0 UM_Target_ID lauroylcarnitine 10427569 C12:0 UM_Target_ID L-Carnitine 288 L-Carnitine UM_Target_ID Linoelaidyl carnitine 53477834 C18:2 UM_Target_ID myristoylcarnitine 53477791 C14:0 UM_Target_ID octanoylcarnitine 123701 C8:0 UM_Target_ID Octenoylcarnitine 71464472 C8:1 UM_Target_ID Oleoylcarnitine 6441392 C18:1 UM_Target_ID Palmitoleylcarnitine 71464547 C16:1 UM_Target_ID palmitoylcarnitine 11953816 C02990 C16:0 UM_Target_ID propionylcarnitine 188824 C03017 C3 UM_Target_ID Stearoylcarnitine 52922056 C18:0 UM_Target_ID Tetradecadiencarnitine 71464539 C14:2 UM_Target_ID Tetradecenoylcarnitine 22833575 C14:1 UM_Target_ID METABOLITES_END #END