#METABOLOMICS WORKBENCH kcontrep_20210726_225458 DATATRACK_ID:2771 STUDY_ID:ST001889 ANALYSIS_ID:AN003065 PROJECT_ID:PR001190 VERSION 1 CREATED_ON August 2, 2021, 11:09 am #PROJECT PR:PROJECT_TITLE Preeclampsia and plasma metabolomics PR:PROJECT_SUMMARY Longitudinal untargeted plasma metabolomics of pregnant women with preeclampsia PR:INSTITUTE Stanford University PR:LAST_NAME Contrepois PR:FIRST_NAME Kevin PR:ADDRESS 300 Pasteur Dr PR:EMAIL kcontrep@stanford.edu PR:PHONE 6506664538 #STUDY ST:STUDY_TITLE Multiomics Longitudinal Modeling of Preeclamptic Pregnancies (part I) ST:STUDY_SUMMARY Preeclampsia is a complex disease of pregnancy whose physiopathology remains ST:STUDY_SUMMARY unclear and that poses a threat to both mothers and infants. Specific complex ST:STUDY_SUMMARY changes in women's physiology precede a diagnosis of preeclampsia. Understanding ST:STUDY_SUMMARY multiple aspects of such a complex changes at different levels of biology can be ST:STUDY_SUMMARY enabled by simultaneous application of multiple assays. We developed prediction ST:STUDY_SUMMARY models for preeclampsia risk by analyzing six omics datasets from a longitudinal ST:STUDY_SUMMARY cohort of pregnant women. A machine learning-based multiomics model had high ST:STUDY_SUMMARY accuracy (area under the receiver operating characteristics curve (AUC) of 0.94, ST:STUDY_SUMMARY 95% confidence intervals (CI): [0.90, 0.99]). A prediction model using only ten ST:STUDY_SUMMARY urine metabolites provided an accuracy of the whole metabolomic dataset and was ST:STUDY_SUMMARY validated using an independent cohort of 16 women (AUC=0.87, 95% CI: [0.76, ST:STUDY_SUMMARY 0.99]). Integration with clinical variables further improved prediction accuracy ST:STUDY_SUMMARY of the urine metabolome model (AUC=0.90, 95% CI: [0.80, 0.99], urine metabolome, ST:STUDY_SUMMARY validated). We identified several biological pathways to be associated with ST:STUDY_SUMMARY preeclampsia. The findings derived from models were integrated with immune ST:STUDY_SUMMARY system cytometry data, confirming known physiological alterations associated ST:STUDY_SUMMARY with preeclampsia and suggesting novel associations between the immune and ST:STUDY_SUMMARY proteomic dynamics. While further validation in larger populations is necessary, ST:STUDY_SUMMARY these encouraging results will serve as a basis for a simple, early diagnostic ST:STUDY_SUMMARY test for preeclampsia. ST:INSTITUTE Stanford University ST:LAST_NAME Contrepois ST:FIRST_NAME Kevin ST:ADDRESS 300 Pasteur Dr ST:EMAIL kcontrep@stanford.edu ST:PHONE 6506664538 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS 10056 1005608055 Gestational Age At Sampling:5 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1005608055; RAW_FILE_NAME=nHILIC_1005608055; RAW_FILE_NAME=pRPLC_1005608055; RAW_FILE_NAME=nRPLC_1005608055 SUBJECT_SAMPLE_FACTORS 10056 1005608155 Gestational Age At Sampling:15 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1005608155; RAW_FILE_NAME=nHILIC_1005608155; RAW_FILE_NAME=pRPLC_1005608155; RAW_FILE_NAME=nRPLC_1005608155 SUBJECT_SAMPLE_FACTORS 10056 1005608265 Gestational Age At Sampling:26 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1005608265; RAW_FILE_NAME=nHILIC_1005608265; RAW_FILE_NAME=pRPLC_1005608265; RAW_FILE_NAME=nRPLC_1005608265 SUBJECT_SAMPLE_FACTORS 10056 1005608365 Gestational Age At Sampling:36 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1005608365; RAW_FILE_NAME=nHILIC_1005608365; RAW_FILE_NAME=pRPLC_1005608365; RAW_FILE_NAME=nRPLC_1005608365 SUBJECT_SAMPLE_FACTORS 10104 1010408165 Gestational Age At Sampling:16 | Gestational Age At Delivery:32 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1010408165; RAW_FILE_NAME=nHILIC_1010408165; RAW_FILE_NAME=pRPLC_1010408165; RAW_FILE_NAME=nRPLC_1010408165 SUBJECT_SAMPLE_FACTORS 10104 1010408235 Gestational Age At Sampling:23 | Gestational Age At Delivery:32 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1010408235; RAW_FILE_NAME=nHILIC_1010408235; RAW_FILE_NAME=pRPLC_1010408235; RAW_FILE_NAME=nRPLC_1010408235 SUBJECT_SAMPLE_FACTORS 10104 1010408325 Gestational Age At Sampling:32 | Gestational Age At Delivery:32 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1010408325; RAW_FILE_NAME=nHILIC_1010408325; RAW_FILE_NAME=pRPLC_1010408325; RAW_FILE_NAME=nRPLC_1010408325 SUBJECT_SAMPLE_FACTORS 10112 1011208155 Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1011208155; RAW_FILE_NAME=nHILIC_1011208155; RAW_FILE_NAME=pRPLC_1011208155; RAW_FILE_NAME=nRPLC_1011208155 SUBJECT_SAMPLE_FACTORS 10112 1011208265 Gestational Age At Sampling:26 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1011208265; RAW_FILE_NAME=nHILIC_1011208265; RAW_FILE_NAME=pRPLC_1011208265; RAW_FILE_NAME=nRPLC_1011208265 SUBJECT_SAMPLE_FACTORS 10112 1011208395 Gestational Age At Sampling:39 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1011208395; RAW_FILE_NAME=nHILIC_1011208395; RAW_FILE_NAME=pRPLC_1011208395; RAW_FILE_NAME=nRPLC_1011208395 SUBJECT_SAMPLE_FACTORS 10502 1050208105 Gestational Age At Sampling:10 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1050208105; RAW_FILE_NAME=nHILIC_1050208105; RAW_FILE_NAME=pRPLC_1050208105; RAW_FILE_NAME=nRPLC_1050208105 SUBJECT_SAMPLE_FACTORS 10502 1050208255 Gestational Age At Sampling:25 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1050208255; RAW_FILE_NAME=nHILIC_1050208255; RAW_FILE_NAME=pRPLC_1050208255; RAW_FILE_NAME=nRPLC_1050208255 SUBJECT_SAMPLE_FACTORS 10502 1050208415 Gestational Age At Sampling:41 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1050208415; RAW_FILE_NAME=nHILIC_1050208415; RAW_FILE_NAME=pRPLC_1050208415; RAW_FILE_NAME=nRPLC_1050208415 SUBJECT_SAMPLE_FACTORS 10503 1050308185 Gestational Age At Sampling:18 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1050308185; RAW_FILE_NAME=nHILIC_1050308185; RAW_FILE_NAME=pRPLC_1050308185; RAW_FILE_NAME=nRPLC_1050308185 SUBJECT_SAMPLE_FACTORS 10503 1050308275 Gestational Age At Sampling:27 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1050308275; RAW_FILE_NAME=nHILIC_1050308275; RAW_FILE_NAME=pRPLC_1050308275; RAW_FILE_NAME=nRPLC_1050308275 SUBJECT_SAMPLE_FACTORS 10503 1050308415 Gestational Age At Sampling:41 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1050308415; RAW_FILE_NAME=nHILIC_1050308415; RAW_FILE_NAME=pRPLC_1050308415; RAW_FILE_NAME=nRPLC_1050308415 SUBJECT_SAMPLE_FACTORS 10505 1050508085 Gestational Age At Sampling:8 | Gestational Age At Delivery:37 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1050508085; RAW_FILE_NAME=nHILIC_1050508085; RAW_FILE_NAME=pRPLC_1050508085; RAW_FILE_NAME=nRPLC_1050508085 SUBJECT_SAMPLE_FACTORS 10505 1050508175 Gestational Age At Sampling:17 | Gestational Age At Delivery:37 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1050508175; RAW_FILE_NAME=nHILIC_1050508175; RAW_FILE_NAME=pRPLC_1050508175; RAW_FILE_NAME=nRPLC_1050508175 SUBJECT_SAMPLE_FACTORS 10505 1050508264 Gestational Age At Sampling:26 | Gestational Age At Delivery:37 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1050508264; RAW_FILE_NAME=nHILIC_1050508264; RAW_FILE_NAME=pRPLC_1050508264; RAW_FILE_NAME=nRPLC_1050508264 SUBJECT_SAMPLE_FACTORS 10505 1050508385 Gestational Age At Sampling:38 | Gestational Age At Delivery:37 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1050508385; RAW_FILE_NAME=nHILIC_1050508385; RAW_FILE_NAME=pRPLC_1050508385; RAW_FILE_NAME=nRPLC_1050508385 SUBJECT_SAMPLE_FACTORS 10515 1051508115 Gestational Age At Sampling:11 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1051508115; RAW_FILE_NAME=nHILIC_1051508115; RAW_FILE_NAME=pRPLC_1051508115; RAW_FILE_NAME=nRPLC_1051508115 SUBJECT_SAMPLE_FACTORS 10515 1051508155 Gestational Age At Sampling:15 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1051508155; RAW_FILE_NAME=nHILIC_1051508155; RAW_FILE_NAME=pRPLC_1051508155; RAW_FILE_NAME=nRPLC_1051508155 SUBJECT_SAMPLE_FACTORS 10515 1051508254 Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1051508254; RAW_FILE_NAME=nHILIC_1051508254; RAW_FILE_NAME=pRPLC_1051508254; RAW_FILE_NAME=nRPLC_1051508254 SUBJECT_SAMPLE_FACTORS 10515 1051508405 Gestational Age At Sampling:40 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1051508405; RAW_FILE_NAME=nHILIC_1051508405; RAW_FILE_NAME=pRPLC_1051508405; RAW_FILE_NAME=nRPLC_1051508405 SUBJECT_SAMPLE_FACTORS 10523 1052308085 Gestational Age At Sampling:8 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052308085; RAW_FILE_NAME=nHILIC_1052308085; RAW_FILE_NAME=pRPLC_1052308085; RAW_FILE_NAME=nRPLC_1052308085 SUBJECT_SAMPLE_FACTORS 10523 1052308155 Gestational Age At Sampling:15 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052308155; RAW_FILE_NAME=nHILIC_1052308155; RAW_FILE_NAME=pRPLC_1052308155; RAW_FILE_NAME=nRPLC_1052308155 SUBJECT_SAMPLE_FACTORS 10523 1052308284 Gestational Age At Sampling:28 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052308284; RAW_FILE_NAME=nHILIC_1052308284; RAW_FILE_NAME=pRPLC_1052308284; RAW_FILE_NAME=nRPLC_1052308284 SUBJECT_SAMPLE_FACTORS 10523 1052308415 Gestational Age At Sampling:41 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052308415; RAW_FILE_NAME=nHILIC_1052308415; RAW_FILE_NAME=pRPLC_1052308415; RAW_FILE_NAME=nRPLC_1052308415 SUBJECT_SAMPLE_FACTORS 10524 1052408115 Gestational Age At Sampling:11 | Gestational Age At Delivery:38 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052408115; RAW_FILE_NAME=nHILIC_1052408115; RAW_FILE_NAME=pRPLC_1052408115; RAW_FILE_NAME=nRPLC_1052408115 SUBJECT_SAMPLE_FACTORS 10524 1052408184 Gestational Age At Sampling:18 | Gestational Age At Delivery:38 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052408184; RAW_FILE_NAME=nHILIC_1052408184; RAW_FILE_NAME=pRPLC_1052408184; RAW_FILE_NAME=nRPLC_1052408184 SUBJECT_SAMPLE_FACTORS 10524 1052408265 Gestational Age At Sampling:26 | Gestational Age At Delivery:38 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052408265; RAW_FILE_NAME=nHILIC_1052408265; RAW_FILE_NAME=pRPLC_1052408265; RAW_FILE_NAME=nRPLC_1052408265 SUBJECT_SAMPLE_FACTORS 10524 1052408385 Gestational Age At Sampling:38 | Gestational Age At Delivery:38 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052408385; RAW_FILE_NAME=nHILIC_1052408385; RAW_FILE_NAME=pRPLC_1052408385; RAW_FILE_NAME=nRPLC_1052408385 SUBJECT_SAMPLE_FACTORS 10528 1052808105 Gestational Age At Sampling:10 | Gestational Age At Delivery:38 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052808105; RAW_FILE_NAME=nHILIC_1052808105; RAW_FILE_NAME=pRPLC_1052808105; RAW_FILE_NAME=nRPLC_1052808105 SUBJECT_SAMPLE_FACTORS 10528 1052808285 Gestational Age At Sampling:28 | Gestational Age At Delivery:38 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052808285; RAW_FILE_NAME=nHILIC_1052808285; RAW_FILE_NAME=pRPLC_1052808285; RAW_FILE_NAME=nRPLC_1052808285 SUBJECT_SAMPLE_FACTORS 10528 1052808385 Gestational Age At Sampling:38 | Gestational Age At Delivery:38 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1052808385; RAW_FILE_NAME=nHILIC_1052808385; RAW_FILE_NAME=pRPLC_1052808385; RAW_FILE_NAME=nRPLC_1052808385 SUBJECT_SAMPLE_FACTORS 10530 1053008155 Gestational Age At Sampling:15 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1053008155; RAW_FILE_NAME=nHILIC_1053008155; RAW_FILE_NAME=pRPLC_1053008155; RAW_FILE_NAME=nRPLC_1053008155 SUBJECT_SAMPLE_FACTORS 10530 1053008335 Gestational Age At Sampling:33 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1053008335; RAW_FILE_NAME=nHILIC_1053008335; RAW_FILE_NAME=pRPLC_1053008335; RAW_FILE_NAME=nRPLC_1053008335 SUBJECT_SAMPLE_FACTORS 10530 1053008365 Gestational Age At Sampling:36 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1053008365; RAW_FILE_NAME=nHILIC_1053008365; RAW_FILE_NAME=pRPLC_1053008365; RAW_FILE_NAME=nRPLC_1053008365 SUBJECT_SAMPLE_FACTORS 10533 1053308175 Gestational Age At Sampling:17 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1053308175; RAW_FILE_NAME=nHILIC_1053308175; RAW_FILE_NAME=pRPLC_1053308175; RAW_FILE_NAME=nRPLC_1053308175 SUBJECT_SAMPLE_FACTORS 10533 1053308265 Gestational Age At Sampling:26 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1053308265; RAW_FILE_NAME=nHILIC_1053308265; RAW_FILE_NAME=pRPLC_1053308265; RAW_FILE_NAME=nRPLC_1053308265 SUBJECT_SAMPLE_FACTORS 10533 1053308375 Gestational Age At Sampling:37 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1053308375; RAW_FILE_NAME=nHILIC_1053308375; RAW_FILE_NAME=pRPLC_1053308375; RAW_FILE_NAME=nRPLC_1053308375 SUBJECT_SAMPLE_FACTORS 10535 1053508115 Gestational Age At Sampling:11 | Gestational Age At Delivery:38 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1053508115; RAW_FILE_NAME=nHILIC_1053508115; RAW_FILE_NAME=pRPLC_1053508115; RAW_FILE_NAME=nRPLC_1053508115 SUBJECT_SAMPLE_FACTORS 10535 1053508165 Gestational Age At Sampling:16 | Gestational Age At Delivery:38 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1053508165; RAW_FILE_NAME=nHILIC_1053508165; RAW_FILE_NAME=pRPLC_1053508165; RAW_FILE_NAME=nRPLC_1053508165 SUBJECT_SAMPLE_FACTORS 10535 1053508275 Gestational Age At Sampling:27 | Gestational Age At Delivery:38 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1053508275; RAW_FILE_NAME=nHILIC_1053508275; RAW_FILE_NAME=pRPLC_1053508275; RAW_FILE_NAME=nRPLC_1053508275 SUBJECT_SAMPLE_FACTORS 10538 1053808085 Gestational Age At Sampling:8 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1053808085; RAW_FILE_NAME=nHILIC_1053808085; RAW_FILE_NAME=pRPLC_1053808085; RAW_FILE_NAME=nRPLC_1053808085 SUBJECT_SAMPLE_FACTORS 10538 1053808165 Gestational Age At Sampling:16 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1053808165; RAW_FILE_NAME=nHILIC_1053808165; RAW_FILE_NAME=pRPLC_1053808165; RAW_FILE_NAME=nRPLC_1053808165 SUBJECT_SAMPLE_FACTORS 10538 1053808284 Gestational Age At Sampling:28 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1053808284; RAW_FILE_NAME=nHILIC_1053808284; RAW_FILE_NAME=pRPLC_1053808284; RAW_FILE_NAME=nRPLC_1053808284 SUBJECT_SAMPLE_FACTORS 10538 1053808395 Gestational Age At Sampling:39 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1053808395; RAW_FILE_NAME=nHILIC_1053808395; RAW_FILE_NAME=pRPLC_1053808395; RAW_FILE_NAME=nRPLC_1053808395 SUBJECT_SAMPLE_FACTORS 10541 1054108095 Gestational Age At Sampling:9 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054108095; RAW_FILE_NAME=nHILIC_1054108095; RAW_FILE_NAME=pRPLC_1054108095; RAW_FILE_NAME=nRPLC_1054108095 SUBJECT_SAMPLE_FACTORS 10541 1054108155 Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054108155; RAW_FILE_NAME=nHILIC_1054108155; RAW_FILE_NAME=pRPLC_1054108155; RAW_FILE_NAME=nRPLC_1054108155 SUBJECT_SAMPLE_FACTORS 10541 1054108274 Gestational Age At Sampling:27 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054108274; RAW_FILE_NAME=nHILIC_1054108274; RAW_FILE_NAME=pRPLC_1054108274; RAW_FILE_NAME=nRPLC_1054108274 SUBJECT_SAMPLE_FACTORS 10541 1054108394 Gestational Age At Sampling:39 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054108394; RAW_FILE_NAME=nHILIC_1054108394; RAW_FILE_NAME=pRPLC_1054108394; RAW_FILE_NAME=nRPLC_1054108394 SUBJECT_SAMPLE_FACTORS 10546 1054608095 Gestational Age At Sampling:9 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054608095; RAW_FILE_NAME=nHILIC_1054608095; RAW_FILE_NAME=pRPLC_1054608095; RAW_FILE_NAME=nRPLC_1054608095 SUBJECT_SAMPLE_FACTORS 10546 1054608155 Gestational Age At Sampling:15 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054608155; RAW_FILE_NAME=nHILIC_1054608155; RAW_FILE_NAME=pRPLC_1054608155; RAW_FILE_NAME=nRPLC_1054608155 SUBJECT_SAMPLE_FACTORS 10546 1054608295 Gestational Age At Sampling:29 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054608295; RAW_FILE_NAME=nHILIC_1054608295; RAW_FILE_NAME=pRPLC_1054608295; RAW_FILE_NAME=nRPLC_1054608295 SUBJECT_SAMPLE_FACTORS 10546 1054608415 Gestational Age At Sampling:41 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054608415; RAW_FILE_NAME=nHILIC_1054608415; RAW_FILE_NAME=pRPLC_1054608415; RAW_FILE_NAME=nRPLC_1054608415 SUBJECT_SAMPLE_FACTORS 10547 1054708105 Gestational Age At Sampling:10 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054708105; RAW_FILE_NAME=nHILIC_1054708105; RAW_FILE_NAME=pRPLC_1054708105; RAW_FILE_NAME=nRPLC_1054708105 SUBJECT_SAMPLE_FACTORS 10547 1054708155 Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054708155; RAW_FILE_NAME=nHILIC_1054708155; RAW_FILE_NAME=pRPLC_1054708155; RAW_FILE_NAME=nRPLC_1054708155 SUBJECT_SAMPLE_FACTORS 10547 1054708245 Gestational Age At Sampling:24 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054708245; RAW_FILE_NAME=nHILIC_1054708245; RAW_FILE_NAME=pRPLC_1054708245; RAW_FILE_NAME=nRPLC_1054708245 SUBJECT_SAMPLE_FACTORS 10547 1054708395 Gestational Age At Sampling:39 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054708395; RAW_FILE_NAME=nHILIC_1054708395; RAW_FILE_NAME=pRPLC_1054708395; RAW_FILE_NAME=nRPLC_1054708395 SUBJECT_SAMPLE_FACTORS 10548 1054808185 Gestational Age At Sampling:18 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054808185; RAW_FILE_NAME=nHILIC_1054808185; RAW_FILE_NAME=pRPLC_1054808185; RAW_FILE_NAME=nRPLC_1054808185 SUBJECT_SAMPLE_FACTORS 10548 1054808255 Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1054808255; RAW_FILE_NAME=nHILIC_1054808255; RAW_FILE_NAME=pRPLC_1054808255; RAW_FILE_NAME=nRPLC_1054808255 SUBJECT_SAMPLE_FACTORS 10551 1055108105 Gestational Age At Sampling:10 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1055108105; RAW_FILE_NAME=nHILIC_1055108105; RAW_FILE_NAME=pRPLC_1055108105; RAW_FILE_NAME=nRPLC_1055108105 SUBJECT_SAMPLE_FACTORS 10551 1055108155 Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1055108155; RAW_FILE_NAME=nHILIC_1055108155; RAW_FILE_NAME=pRPLC_1055108155; RAW_FILE_NAME=nRPLC_1055108155 SUBJECT_SAMPLE_FACTORS 10551 1055108265 Gestational Age At Sampling:26 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1055108265; RAW_FILE_NAME=nHILIC_1055108265; RAW_FILE_NAME=pRPLC_1055108265; RAW_FILE_NAME=nRPLC_1055108265 SUBJECT_SAMPLE_FACTORS 10553 1055308175 Gestational Age At Sampling:17 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1055308175; RAW_FILE_NAME=nHILIC_1055308175; RAW_FILE_NAME=pRPLC_1055308175; RAW_FILE_NAME=nRPLC_1055308175 SUBJECT_SAMPLE_FACTORS 10553 1055308245 Gestational Age At Sampling:24 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1055308245; RAW_FILE_NAME=nHILIC_1055308245; RAW_FILE_NAME=pRPLC_1055308245; RAW_FILE_NAME=nRPLC_1055308245 SUBJECT_SAMPLE_FACTORS 10553 1055308375 Gestational Age At Sampling:37 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1055308375; RAW_FILE_NAME=nHILIC_1055308375; RAW_FILE_NAME=pRPLC_1055308375; RAW_FILE_NAME=nRPLC_1055308375 SUBJECT_SAMPLE_FACTORS 10558 1055808085 Gestational Age At Sampling:8 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1055808085; RAW_FILE_NAME=nHILIC_1055808085; RAW_FILE_NAME=pRPLC_1055808085; RAW_FILE_NAME=nRPLC_1055808085 SUBJECT_SAMPLE_FACTORS 10558 1055808155 Gestational Age At Sampling:15 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1055808155; RAW_FILE_NAME=nHILIC_1055808155; RAW_FILE_NAME=pRPLC_1055808155; RAW_FILE_NAME=nRPLC_1055808155 SUBJECT_SAMPLE_FACTORS 10558 1055808255 Gestational Age At Sampling:25 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1055808255; RAW_FILE_NAME=nHILIC_1055808255; RAW_FILE_NAME=pRPLC_1055808255; RAW_FILE_NAME=nRPLC_1055808255 SUBJECT_SAMPLE_FACTORS 10558 1055808384 Gestational Age At Sampling:38 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1055808384; RAW_FILE_NAME=nHILIC_1055808384; RAW_FILE_NAME=pRPLC_1055808384; RAW_FILE_NAME=nRPLC_1055808384 SUBJECT_SAMPLE_FACTORS 10561 1056108115 Gestational Age At Sampling:11 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1056108115; RAW_FILE_NAME=nHILIC_1056108115; RAW_FILE_NAME=pRPLC_1056108115; RAW_FILE_NAME=nRPLC_1056108115 SUBJECT_SAMPLE_FACTORS 10561 1056108255 Gestational Age At Sampling:25 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1056108255; RAW_FILE_NAME=nHILIC_1056108255; RAW_FILE_NAME=pRPLC_1056108255; RAW_FILE_NAME=nRPLC_1056108255 SUBJECT_SAMPLE_FACTORS 10601 1060108113 Gestational Age At Sampling:11 | Gestational Age At Delivery:40 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1060108113; RAW_FILE_NAME=nHILIC_1060108113; RAW_FILE_NAME=pRPLC_1060108113; RAW_FILE_NAME=nRPLC_1060108113 SUBJECT_SAMPLE_FACTORS 10601 1060108163 Gestational Age At Sampling:16 | Gestational Age At Delivery:40 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1060108163; RAW_FILE_NAME=nHILIC_1060108163; RAW_FILE_NAME=pRPLC_1060108163; RAW_FILE_NAME=nRPLC_1060108163 SUBJECT_SAMPLE_FACTORS 10601 1060108273 Gestational Age At Sampling:27 | Gestational Age At Delivery:40 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1060108273; RAW_FILE_NAME=nHILIC_1060108273; RAW_FILE_NAME=pRPLC_1060108273; RAW_FILE_NAME=nRPLC_1060108273 SUBJECT_SAMPLE_FACTORS 10601 1060108474 Gestational Age At Sampling:47 | Gestational Age At Delivery:40 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1060108474; RAW_FILE_NAME=nHILIC_1060108474; RAW_FILE_NAME=pRPLC_1060108474; RAW_FILE_NAME=nRPLC_1060108474 SUBJECT_SAMPLE_FACTORS 10634 1063408114 Gestational Age At Sampling:11 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1063408114; RAW_FILE_NAME=nHILIC_1063408114; RAW_FILE_NAME=pRPLC_1063408114; RAW_FILE_NAME=nRPLC_1063408114 SUBJECT_SAMPLE_FACTORS 10634 1063408164 Gestational Age At Sampling:16 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1063408164; RAW_FILE_NAME=nHILIC_1063408164; RAW_FILE_NAME=pRPLC_1063408164; RAW_FILE_NAME=nRPLC_1063408164 SUBJECT_SAMPLE_FACTORS 10634 1063408244 Gestational Age At Sampling:24 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1063408244; RAW_FILE_NAME=nHILIC_1063408244; RAW_FILE_NAME=pRPLC_1063408244; RAW_FILE_NAME=nRPLC_1063408244 SUBJECT_SAMPLE_FACTORS 10634 1063408465 Gestational Age At Sampling:46 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1063408465; RAW_FILE_NAME=nHILIC_1063408465; RAW_FILE_NAME=pRPLC_1063408465; RAW_FILE_NAME=nRPLC_1063408465 SUBJECT_SAMPLE_FACTORS 10639 1063908114 Gestational Age At Sampling:11 | Gestational Age At Delivery:41 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1063908114; RAW_FILE_NAME=nHILIC_1063908114; RAW_FILE_NAME=pRPLC_1063908114; RAW_FILE_NAME=nRPLC_1063908114 SUBJECT_SAMPLE_FACTORS 10639 1063908164 Gestational Age At Sampling:16 | Gestational Age At Delivery:41 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1063908164; RAW_FILE_NAME=nHILIC_1063908164; RAW_FILE_NAME=pRPLC_1063908164; RAW_FILE_NAME=nRPLC_1063908164 SUBJECT_SAMPLE_FACTORS 10639 1063908274 Gestational Age At Sampling:27 | Gestational Age At Delivery:41 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1063908274; RAW_FILE_NAME=nHILIC_1063908274; RAW_FILE_NAME=pRPLC_1063908274; RAW_FILE_NAME=nRPLC_1063908274 SUBJECT_SAMPLE_FACTORS 10639 1063908465 Gestational Age At Sampling:46 | Gestational Age At Delivery:41 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1063908465; RAW_FILE_NAME=nHILIC_1063908465; RAW_FILE_NAME=pRPLC_1063908465; RAW_FILE_NAME=nRPLC_1063908465 SUBJECT_SAMPLE_FACTORS 10712 1071208134 Gestational Age At Sampling:13 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1071208134; RAW_FILE_NAME=nHILIC_1071208134; RAW_FILE_NAME=pRPLC_1071208134; RAW_FILE_NAME=nRPLC_1071208134 SUBJECT_SAMPLE_FACTORS 10712 1071208165 Gestational Age At Sampling:16 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1071208165; RAW_FILE_NAME=nHILIC_1071208165; RAW_FILE_NAME=pRPLC_1071208165; RAW_FILE_NAME=nRPLC_1071208165 SUBJECT_SAMPLE_FACTORS 10712 1071208252 Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1071208252; RAW_FILE_NAME=nHILIC_1071208252; RAW_FILE_NAME=pRPLC_1071208252; RAW_FILE_NAME=nRPLC_1071208252 SUBJECT_SAMPLE_FACTORS 10713 1071308113 Gestational Age At Sampling:11 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1071308113; RAW_FILE_NAME=nHILIC_1071308113; RAW_FILE_NAME=pRPLC_1071308113; RAW_FILE_NAME=nRPLC_1071308113 SUBJECT_SAMPLE_FACTORS 10713 1071308174 Gestational Age At Sampling:17 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1071308174; RAW_FILE_NAME=nHILIC_1071308174; RAW_FILE_NAME=pRPLC_1071308174; RAW_FILE_NAME=nRPLC_1071308174 SUBJECT_SAMPLE_FACTORS 10713 1071308262 Gestational Age At Sampling:26 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1071308262; RAW_FILE_NAME=nHILIC_1071308262; RAW_FILE_NAME=pRPLC_1071308262; RAW_FILE_NAME=nRPLC_1071308262 SUBJECT_SAMPLE_FACTORS 10713 1071308485 Gestational Age At Sampling:48 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1071308485; RAW_FILE_NAME=nHILIC_1071308485; RAW_FILE_NAME=pRPLC_1071308485; RAW_FILE_NAME=nRPLC_1071308485 SUBJECT_SAMPLE_FACTORS 10721 1072108114 Gestational Age At Sampling:11 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1072108114; RAW_FILE_NAME=nHILIC_1072108114; RAW_FILE_NAME=pRPLC_1072108114; RAW_FILE_NAME=nRPLC_1072108114 SUBJECT_SAMPLE_FACTORS 10721 1072108182 Gestational Age At Sampling:18 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1072108182; RAW_FILE_NAME=nHILIC_1072108182; RAW_FILE_NAME=pRPLC_1072108182; RAW_FILE_NAME=nRPLC_1072108182 SUBJECT_SAMPLE_FACTORS 10721 1072108274 Gestational Age At Sampling:27 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1072108274; RAW_FILE_NAME=nHILIC_1072108274; RAW_FILE_NAME=pRPLC_1072108274; RAW_FILE_NAME=nRPLC_1072108274 SUBJECT_SAMPLE_FACTORS 10721 1072108455 Gestational Age At Sampling:45 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1072108455; RAW_FILE_NAME=nHILIC_1072108455; RAW_FILE_NAME=pRPLC_1072108455; RAW_FILE_NAME=nRPLC_1072108455 SUBJECT_SAMPLE_FACTORS 10722 1072208124 Gestational Age At Sampling:12 | Gestational Age At Delivery:30 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072208124; RAW_FILE_NAME=nHILIC_1072208124; RAW_FILE_NAME=pRPLC_1072208124; RAW_FILE_NAME=nRPLC_1072208124 SUBJECT_SAMPLE_FACTORS 10722 1072208174 Gestational Age At Sampling:17 | Gestational Age At Delivery:30 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072208174; RAW_FILE_NAME=nHILIC_1072208174; RAW_FILE_NAME=pRPLC_1072208174; RAW_FILE_NAME=nRPLC_1072208174 SUBJECT_SAMPLE_FACTORS 10722 1072208254 Gestational Age At Sampling:25 | Gestational Age At Delivery:30 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072208254; RAW_FILE_NAME=nHILIC_1072208254; RAW_FILE_NAME=pRPLC_1072208254; RAW_FILE_NAME=nRPLC_1072208254 SUBJECT_SAMPLE_FACTORS 10722 1072208365 Gestational Age At Sampling:36 | Gestational Age At Delivery:30 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072208365; RAW_FILE_NAME=nHILIC_1072208365; RAW_FILE_NAME=pRPLC_1072208365; RAW_FILE_NAME=nRPLC_1072208365 SUBJECT_SAMPLE_FACTORS 10723 1072308135 Gestational Age At Sampling:13 | Gestational Age At Delivery:40 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072308135; RAW_FILE_NAME=nHILIC_1072308135; RAW_FILE_NAME=pRPLC_1072308135; RAW_FILE_NAME=nRPLC_1072308135 SUBJECT_SAMPLE_FACTORS 10723 1072308175 Gestational Age At Sampling:17 | Gestational Age At Delivery:40 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072308175; RAW_FILE_NAME=nHILIC_1072308175; RAW_FILE_NAME=pRPLC_1072308175; RAW_FILE_NAME=nRPLC_1072308175 SUBJECT_SAMPLE_FACTORS 10723 1072308255 Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072308255; RAW_FILE_NAME=nHILIC_1072308255; RAW_FILE_NAME=pRPLC_1072308255; RAW_FILE_NAME=nRPLC_1072308255 SUBJECT_SAMPLE_FACTORS 10723 1072308455 Gestational Age At Sampling:45 | Gestational Age At Delivery:40 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072308455; RAW_FILE_NAME=nHILIC_1072308455; RAW_FILE_NAME=pRPLC_1072308455; RAW_FILE_NAME=nRPLC_1072308455 SUBJECT_SAMPLE_FACTORS 10727 1072708114 Gestational Age At Sampling:11 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072708114; RAW_FILE_NAME=nHILIC_1072708114; RAW_FILE_NAME=pRPLC_1072708114; RAW_FILE_NAME=nRPLC_1072708114 SUBJECT_SAMPLE_FACTORS 10727 1072708164 Gestational Age At Sampling:16 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072708164; RAW_FILE_NAME=nHILIC_1072708164; RAW_FILE_NAME=pRPLC_1072708164; RAW_FILE_NAME=nRPLC_1072708164 SUBJECT_SAMPLE_FACTORS 10727 1072708274 Gestational Age At Sampling:27 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1072708274; RAW_FILE_NAME=nHILIC_1072708274; RAW_FILE_NAME=pRPLC_1072708274; RAW_FILE_NAME=nRPLC_1072708274 SUBJECT_SAMPLE_FACTORS 10732 1073208114 Gestational Age At Sampling:11 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1073208114; RAW_FILE_NAME=nHILIC_1073208114; RAW_FILE_NAME=pRPLC_1073208114; RAW_FILE_NAME=nRPLC_1073208114 SUBJECT_SAMPLE_FACTORS 10732 1073208184 Gestational Age At Sampling:18 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1073208184; RAW_FILE_NAME=nHILIC_1073208184; RAW_FILE_NAME=pRPLC_1073208184; RAW_FILE_NAME=nRPLC_1073208184 SUBJECT_SAMPLE_FACTORS 10732 1073208242 Gestational Age At Sampling:24 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1073208242; RAW_FILE_NAME=nHILIC_1073208242; RAW_FILE_NAME=pRPLC_1073208242; RAW_FILE_NAME=nRPLC_1073208242 SUBJECT_SAMPLE_FACTORS 10732 1073208465 Gestational Age At Sampling:46 | Gestational Age At Delivery:40 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1073208465; RAW_FILE_NAME=nHILIC_1073208465; RAW_FILE_NAME=pRPLC_1073208465; RAW_FILE_NAME=nRPLC_1073208465 SUBJECT_SAMPLE_FACTORS 10733 1073308124 Gestational Age At Sampling:12 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1073308124; RAW_FILE_NAME=nHILIC_1073308124; RAW_FILE_NAME=pRPLC_1073308124; RAW_FILE_NAME=nRPLC_1073308124 SUBJECT_SAMPLE_FACTORS 10733 1073308155 Gestational Age At Sampling:15 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1073308155; RAW_FILE_NAME=nHILIC_1073308155; RAW_FILE_NAME=pRPLC_1073308155; RAW_FILE_NAME=nRPLC_1073308155 SUBJECT_SAMPLE_FACTORS 10733 1073308262 Gestational Age At Sampling:26 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1073308262; RAW_FILE_NAME=nHILIC_1073308262; RAW_FILE_NAME=pRPLC_1073308262; RAW_FILE_NAME=nRPLC_1073308262 SUBJECT_SAMPLE_FACTORS 10733 1073308485 Gestational Age At Sampling:48 | Gestational Age At Delivery:41 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1073308485; RAW_FILE_NAME=nHILIC_1073308485; RAW_FILE_NAME=pRPLC_1073308485; RAW_FILE_NAME=nRPLC_1073308485 SUBJECT_SAMPLE_FACTORS 10736 1073608134 Gestational Age At Sampling:13 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1073608134; RAW_FILE_NAME=nHILIC_1073608134; RAW_FILE_NAME=pRPLC_1073608134; RAW_FILE_NAME=nRPLC_1073608134 SUBJECT_SAMPLE_FACTORS 10736 1073608174 Gestational Age At Sampling:17 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1073608174; RAW_FILE_NAME=nHILIC_1073608174; RAW_FILE_NAME=pRPLC_1073608174; RAW_FILE_NAME=nRPLC_1073608174 SUBJECT_SAMPLE_FACTORS 10736 1073608254 Gestational Age At Sampling:25 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1073608254; RAW_FILE_NAME=nHILIC_1073608254; RAW_FILE_NAME=pRPLC_1073608254; RAW_FILE_NAME=nRPLC_1073608254 SUBJECT_SAMPLE_FACTORS 10736 1073608465 Gestational Age At Sampling:46 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1073608465; RAW_FILE_NAME=nHILIC_1073608465; RAW_FILE_NAME=pRPLC_1073608465; RAW_FILE_NAME=nRPLC_1073608465 SUBJECT_SAMPLE_FACTORS 10803 1080308134 Gestational Age At Sampling:13 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1080308134; RAW_FILE_NAME=nHILIC_1080308134; RAW_FILE_NAME=pRPLC_1080308134; RAW_FILE_NAME=nRPLC_1080308134 SUBJECT_SAMPLE_FACTORS 10803 1080308164 Gestational Age At Sampling:16 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1080308164; RAW_FILE_NAME=nHILIC_1080308164; RAW_FILE_NAME=pRPLC_1080308164; RAW_FILE_NAME=nRPLC_1080308164 SUBJECT_SAMPLE_FACTORS 10803 1080308264 Gestational Age At Sampling:26 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1080308264; RAW_FILE_NAME=nHILIC_1080308264; RAW_FILE_NAME=pRPLC_1080308264; RAW_FILE_NAME=nRPLC_1080308264 SUBJECT_SAMPLE_FACTORS 10803 1080308529 Gestational Age At Sampling:52 | Gestational Age At Delivery:36 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1080308529; RAW_FILE_NAME=nHILIC_1080308529; RAW_FILE_NAME=pRPLC_1080308529; RAW_FILE_NAME=nRPLC_1080308529 SUBJECT_SAMPLE_FACTORS 10804 1080408154 Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1080408154; RAW_FILE_NAME=nHILIC_1080408154; RAW_FILE_NAME=pRPLC_1080408154; RAW_FILE_NAME=nRPLC_1080408154 SUBJECT_SAMPLE_FACTORS 10804 1080408282 Gestational Age At Sampling:28 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1080408282; RAW_FILE_NAME=nHILIC_1080408282; RAW_FILE_NAME=pRPLC_1080408282; RAW_FILE_NAME=nRPLC_1080408282 SUBJECT_SAMPLE_FACTORS 10804 1080408465 Gestational Age At Sampling:46 | Gestational Age At Delivery:39 | Preeclampsia:- RAW_FILE_NAME=pHILIC_1080408465; RAW_FILE_NAME=nHILIC_1080408465; RAW_FILE_NAME=pRPLC_1080408465; RAW_FILE_NAME=nRPLC_1080408465 SUBJECT_SAMPLE_FACTORS 10809 1080908114 Gestational Age At Sampling:11 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1080908114; RAW_FILE_NAME=nHILIC_1080908114; RAW_FILE_NAME=pRPLC_1080908114; RAW_FILE_NAME=nRPLC_1080908114 SUBJECT_SAMPLE_FACTORS 10809 1080908184 Gestational Age At Sampling:18 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1080908184; RAW_FILE_NAME=nHILIC_1080908184; RAW_FILE_NAME=pRPLC_1080908184; RAW_FILE_NAME=nRPLC_1080908184 SUBJECT_SAMPLE_FACTORS 10809 1080908244 Gestational Age At Sampling:24 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1080908244; RAW_FILE_NAME=nHILIC_1080908244; RAW_FILE_NAME=pRPLC_1080908244; RAW_FILE_NAME=nRPLC_1080908244 SUBJECT_SAMPLE_FACTORS 10816 1081608114 Gestational Age At Sampling:11 | Gestational Age At Delivery:30 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1081608114; RAW_FILE_NAME=nHILIC_1081608114; RAW_FILE_NAME=pRPLC_1081608114; RAW_FILE_NAME=nRPLC_1081608114 SUBJECT_SAMPLE_FACTORS 10816 1081608164 Gestational Age At Sampling:16 | Gestational Age At Delivery:30 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1081608164; RAW_FILE_NAME=nHILIC_1081608164; RAW_FILE_NAME=pRPLC_1081608164; RAW_FILE_NAME=nRPLC_1081608164 SUBJECT_SAMPLE_FACTORS 10816 1081608248 Gestational Age At Sampling:24 | Gestational Age At Delivery:30 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1081608248; RAW_FILE_NAME=nHILIC_1081608248; RAW_FILE_NAME=pRPLC_1081608248; RAW_FILE_NAME=nRPLC_1081608248 SUBJECT_SAMPLE_FACTORS 10816 1081608489 Gestational Age At Sampling:48 | Gestational Age At Delivery:30 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1081608489; RAW_FILE_NAME=nHILIC_1081608489; RAW_FILE_NAME=pRPLC_1081608489; RAW_FILE_NAME=nRPLC_1081608489 SUBJECT_SAMPLE_FACTORS 10822 1082208139 Gestational Age At Sampling:13 | Gestational Age At Delivery:33 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1082208139; RAW_FILE_NAME=nHILIC_1082208139; RAW_FILE_NAME=pRPLC_1082208139; RAW_FILE_NAME=nRPLC_1082208139 SUBJECT_SAMPLE_FACTORS 10822 1082208169 Gestational Age At Sampling:16 | Gestational Age At Delivery:33 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1082208169; RAW_FILE_NAME=nHILIC_1082208169; RAW_FILE_NAME=pRPLC_1082208169; RAW_FILE_NAME=nRPLC_1082208169 SUBJECT_SAMPLE_FACTORS 10822 1082208289 Gestational Age At Sampling:28 | Gestational Age At Delivery:33 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1082208289; RAW_FILE_NAME=nHILIC_1082208289; RAW_FILE_NAME=pRPLC_1082208289; RAW_FILE_NAME=nRPLC_1082208289 SUBJECT_SAMPLE_FACTORS 10822 1082208459 Gestational Age At Sampling:45 | Gestational Age At Delivery:33 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1082208459; RAW_FILE_NAME=nHILIC_1082208459; RAW_FILE_NAME=pRPLC_1082208459; RAW_FILE_NAME=nRPLC_1082208459 SUBJECT_SAMPLE_FACTORS 10824 1082408129 Gestational Age At Sampling:12 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1082408129; RAW_FILE_NAME=nHILIC_1082408129; RAW_FILE_NAME=pRPLC_1082408129; RAW_FILE_NAME=nRPLC_1082408129 SUBJECT_SAMPLE_FACTORS 10824 1082408169 Gestational Age At Sampling:16 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1082408169; RAW_FILE_NAME=nHILIC_1082408169; RAW_FILE_NAME=pRPLC_1082408169; RAW_FILE_NAME=nRPLC_1082408169 SUBJECT_SAMPLE_FACTORS 10824 1082408289 Gestational Age At Sampling:28 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1082408289; RAW_FILE_NAME=nHILIC_1082408289; RAW_FILE_NAME=pRPLC_1082408289; RAW_FILE_NAME=nRPLC_1082408289 SUBJECT_SAMPLE_FACTORS 10833 1083308119 Gestational Age At Sampling:11 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1083308119; RAW_FILE_NAME=nHILIC_1083308119; RAW_FILE_NAME=pRPLC_1083308119; RAW_FILE_NAME=nRPLC_1083308119 SUBJECT_SAMPLE_FACTORS 10833 1083308159 Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1083308159; RAW_FILE_NAME=nHILIC_1083308159; RAW_FILE_NAME=pRPLC_1083308159; RAW_FILE_NAME=nRPLC_1083308159 SUBJECT_SAMPLE_FACTORS 10833 1083308249 Gestational Age At Sampling:24 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1083308249; RAW_FILE_NAME=nHILIC_1083308249; RAW_FILE_NAME=pRPLC_1083308249; RAW_FILE_NAME=nRPLC_1083308249 SUBJECT_SAMPLE_FACTORS 10836 1083608109 Gestational Age At Sampling:10 | Gestational Age At Delivery:35 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1083608109; RAW_FILE_NAME=nHILIC_1083608109; RAW_FILE_NAME=pRPLC_1083608109; RAW_FILE_NAME=nRPLC_1083608109 SUBJECT_SAMPLE_FACTORS 10836 1083608159 Gestational Age At Sampling:15 | Gestational Age At Delivery:35 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1083608159; RAW_FILE_NAME=nHILIC_1083608159; RAW_FILE_NAME=pRPLC_1083608159; RAW_FILE_NAME=nRPLC_1083608159 SUBJECT_SAMPLE_FACTORS 10840 1084008129 Gestational Age At Sampling:12 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1084008129; RAW_FILE_NAME=nHILIC_1084008129; RAW_FILE_NAME=pRPLC_1084008129; RAW_FILE_NAME=nRPLC_1084008129 SUBJECT_SAMPLE_FACTORS 19017 1901708105 Gestational Age At Sampling:10 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1901708105; RAW_FILE_NAME=nHILIC_1901708105; RAW_FILE_NAME=pRPLC_1901708105; RAW_FILE_NAME=nRPLC_1901708105 SUBJECT_SAMPLE_FACTORS 19017 1901708165 Gestational Age At Sampling:16 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1901708165; RAW_FILE_NAME=nHILIC_1901708165; RAW_FILE_NAME=pRPLC_1901708165; RAW_FILE_NAME=nRPLC_1901708165 SUBJECT_SAMPLE_FACTORS 19017 1901708255 Gestational Age At Sampling:25 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1901708255; RAW_FILE_NAME=nHILIC_1901708255; RAW_FILE_NAME=pRPLC_1901708255; RAW_FILE_NAME=nRPLC_1901708255 SUBJECT_SAMPLE_FACTORS 19017 1901708375 Gestational Age At Sampling:37 | Gestational Age At Delivery:37 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1901708375; RAW_FILE_NAME=nHILIC_1901708375; RAW_FILE_NAME=pRPLC_1901708375; RAW_FILE_NAME=nRPLC_1901708375 SUBJECT_SAMPLE_FACTORS 19024 1902408095 Gestational Age At Sampling:9 | Gestational Age At Delivery:31 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1902408095; RAW_FILE_NAME=nHILIC_1902408095; RAW_FILE_NAME=pRPLC_1902408095; RAW_FILE_NAME=nRPLC_1902408095 SUBJECT_SAMPLE_FACTORS 19024 1902408295 Gestational Age At Sampling:29 | Gestational Age At Delivery:31 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1902408295; RAW_FILE_NAME=nHILIC_1902408295; RAW_FILE_NAME=pRPLC_1902408295; RAW_FILE_NAME=nRPLC_1902408295 SUBJECT_SAMPLE_FACTORS 19600 1960008085 Gestational Age At Sampling:8 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1960008085; RAW_FILE_NAME=nHILIC_1960008085; RAW_FILE_NAME=pRPLC_1960008085; RAW_FILE_NAME=nRPLC_1960008085 SUBJECT_SAMPLE_FACTORS 19600 1960008175 Gestational Age At Sampling:17 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1960008175; RAW_FILE_NAME=nHILIC_1960008175; RAW_FILE_NAME=pRPLC_1960008175; RAW_FILE_NAME=nRPLC_1960008175 SUBJECT_SAMPLE_FACTORS 19600 1960008253 Gestational Age At Sampling:25 | Gestational Age At Delivery:39 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_1960008253; RAW_FILE_NAME=nHILIC_1960008253; RAW_FILE_NAME=pRPLC_1960008253; RAW_FILE_NAME=nRPLC_1960008253 SUBJECT_SAMPLE_FACTORS 20070 2007008085 Gestational Age At Sampling:8 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_2007008085; RAW_FILE_NAME=nHILIC_2007008085; RAW_FILE_NAME=pRPLC_2007008085; RAW_FILE_NAME=nRPLC_2007008085 SUBJECT_SAMPLE_FACTORS 20070 2007008335 Gestational Age At Sampling:33 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_2007008335; RAW_FILE_NAME=nHILIC_2007008335; RAW_FILE_NAME=pRPLC_2007008335; RAW_FILE_NAME=nRPLC_2007008335 SUBJECT_SAMPLE_FACTORS 20070 2007008385 Gestational Age At Sampling:38 | Gestational Age At Delivery:38 | Preeclampsia:1 RAW_FILE_NAME=pHILIC_2007008385; RAW_FILE_NAME=nHILIC_2007008385; RAW_FILE_NAME=pRPLC_2007008385; RAW_FILE_NAME=nRPLC_2007008385 #COLLECTION CO:COLLECTION_SUMMARY Intravenous blood was collected from pregnant women CO:SAMPLE_TYPE Blood (plasma) #TREATMENT TR:TREATMENT_SUMMARY N/A #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Plasma samples were thawed on ice, prepared and analyzed randomly as previously SP:SAMPLEPREP_SUMMARY described (Contrepois et al., 2015, Contrepois et al., 2018). Briefly, SP:SAMPLEPREP_SUMMARY metabolites were extracted using 1:1:1 acetone:acetonitrile:methanol, evaporated SP:SAMPLEPREP_SUMMARY to dryness under nitrogen and reconstituted in 1:1 methanol:water before SP:SAMPLEPREP_SUMMARY analysis. Fifteen labeled metabolite internal standards (IS) were added to each SP:SAMPLEPREP_SUMMARY sample to control for extraction efficiency and LC-MS performance. Complex SP:SAMPLEPREP_SUMMARY lipids were prepared using a biphasic separation with cold methyl tert-butyl SP:SAMPLEPREP_SUMMARY ether (MTBE), methanol and water and reconstituted in 9:1 methanol:toluene. Each SP:SAMPLEPREP_SUMMARY sample was spiked-in with deuterated lipid IS (Sciex, cat#: 5040156) used for SP:SAMPLEPREP_SUMMARY quantification. For quality controls, 3 reference plasma samples (40 µl plasma) SP:SAMPLEPREP_SUMMARY and 1 preparation blank were processed in parallel. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY RPLC experiments were performed using a Zorbax SBaq column 2.1 x 50 mm, 1.7 μm, CH:CHROMATOGRAPHY_SUMMARY 100Å (Agilent Technologies, Palo Alto, CA) and mobile phase solvents consisting CH:CHROMATOGRAPHY_SUMMARY of 0.06% acetic acid in water (A) and 0.06% acetic acid in methanol (B). CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Dionex Ultimate 3000 RS CH:COLUMN_NAME Agilent Zorbax SBaq (50 x 2.1 mm, 1.7 μm) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS Data were acquired on a Thermo Q Exactive HF mass spectrometer for HILIC and a MS:MS_COMMENTS Thermo Q Exactive mass spectrometer for RPLC operated in full MS scan mode. MS:MS_COMMENTS MS/MS data were acquired on quality control samples (QC) consisting of an MS:MS_COMMENTS equimolar mixture of all samples in the study. Data from each mode were MS:MS_COMMENTS independently processed using Progenesis QI software (v2.3) (Nonlinear Dynamics, MS:MS_COMMENTS Durham, NC). Metabolic features from blanks and those that didn’t show MS:MS_COMMENTS sufficient linearity upon dilution in QC samples (r<0.6) were discarded. Only MS:MS_COMMENTS metabolic features present in >2/3 of the samples were kept for further MS:MS_COMMENTS analysis. Inter- and intra-batch variations was were corrected using the LOESS MS:MS_COMMENTS (locally estimated scatterplot smoothing Local Regression) normalization method MS:MS_COMMENTS on QC injected repetitively along the batches (span = 0.75). Missing values were MS:MS_COMMENTS imputed by drawing from a random distribution of low values in the corresponding MS:MS_COMMENTS sample. MS:MS_RESULTS_FILE ST001889_AN003065_Results.txt UNITS:MS count Has m/z:Yes Has RT:Yes RT units:Minutes #END