#METABOLOMICS WORKBENCH basilm_20220506_105941_mwtab.txt DATATRACK_ID:3225 STUDY_ID:ST002112 ANALYSIS_ID:AN004116 PROJECT_ID:PR001338 VERSION 1 CREATED_ON May 18, 2022, 5:28 pm #PROJECT PR:PROJECT_TITLE Health benefits of dietary fiber supplementation. PR:PROJECT_SUMMARY Untargeted metabolomics to understand health benefits of dietary fiber PR:PROJECT_SUMMARY supplementation. PR:INSTITUTE Stanford University PR:LAST_NAME Lancaster PR:FIRST_NAME Samuel PR:ADDRESS 240 Pasteur Dr, BMI bldg 4400, Stanford California, 94305 PR:EMAIL slancast@stanford.edu PR:PHONE 6126004033 #STUDY ST:STUDY_TITLE Global, distinctive and personal changes in molecular and microbial profiles ST:STUDY_TITLE induced by specific fibers in humans (Untargeted) ST:STUDY_SUMMARY Dietary fibers act through the microbiome and improve cardiovascular health, ST:STUDY_SUMMARY metabolic disorders and cancer prevention. To understand health benefits of ST:STUDY_SUMMARY dietary fiber supplementation we investigated two popular purified fibers, ST:STUDY_SUMMARY arabinoxylan (AX) and long-chain inulin (LCI), and a mixture of five fibers. We ST:STUDY_SUMMARY present multi-omic signatures of metabolomics, lipidomics, proteomics, ST:STUDY_SUMMARY metagenomics, a cytokine panel and clinical measurements on healthy and insulin ST:STUDY_SUMMARY resistant participants. Each fiber is associated with fiber-dependent ST:STUDY_SUMMARY biochemical and microbial responses. AX consumption associates with a ST:STUDY_SUMMARY significant reduction in LDL and an increase in bile acids, contributing to its ST:STUDY_SUMMARY observed cholesterol reduction. LCI is associated with an increase in ST:STUDY_SUMMARY Bifidobacterium. However, at the highest LCI dose there is increased ST:STUDY_SUMMARY inflammation and elevation in the liver enzyme alanine aminotransferase. This ST:STUDY_SUMMARY study yields insights into the effects of fiber supplementation, it provides ST:STUDY_SUMMARY insights into mechanisms behind fiber induced cholesterol reduction, and it ST:STUDY_SUMMARY shows effects of individual, purified fibers on the microbiome. ST:INSTITUTE Stanford University ST:LAST_NAME Lancaster ST:FIRST_NAME Samuel ST:ADDRESS 240 Pasteur Dr, BMI bldg 4400, Stanford California, 94305 ST:EMAIL slancast@stanford.edu ST:PHONE 6126004033 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:GENDER Male and female #FACTORS #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - 1 Fiber:Inulin | Timepoint:20 | Sex:F RAW_FILE_NAME=1.RAW SUBJECT_SAMPLE_FACTORS - 2 Fiber:Arabinoxylan | Timepoint:10 | Sex:M RAW_FILE_NAME=2.RAW SUBJECT_SAMPLE_FACTORS - 3 Fiber:Mix | Timepoint:Baseline | Sex:F RAW_FILE_NAME=3.RAW SUBJECT_SAMPLE_FACTORS - 4 Fiber:Inulin | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=4.RAW SUBJECT_SAMPLE_FACTORS - 5 Fiber:Arabinoxylan | Timepoint:20 | Sex:F RAW_FILE_NAME=5.RAW SUBJECT_SAMPLE_FACTORS - 6 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=6.RAW SUBJECT_SAMPLE_FACTORS - 8 Fiber:Inulin | Timepoint:Baseline | Sex:F RAW_FILE_NAME=8.RAW SUBJECT_SAMPLE_FACTORS - 9 Fiber:Inulin | Timepoint:30 | Sex:M RAW_FILE_NAME=9.RAW SUBJECT_SAMPLE_FACTORS - 11 Fiber:Arabinoxylan | Timepoint:20 | Sex:M RAW_FILE_NAME=11.RAW SUBJECT_SAMPLE_FACTORS - 12 Fiber:Mix | Timepoint:30 | Sex:M RAW_FILE_NAME=12.RAW SUBJECT_SAMPLE_FACTORS - 14 Fiber:Arabinoxylan | Timepoint:20 | Sex:M RAW_FILE_NAME=14.RAW SUBJECT_SAMPLE_FACTORS - 15 Fiber:Mix | Timepoint:20 | Sex:M RAW_FILE_NAME=15.RAW SUBJECT_SAMPLE_FACTORS - 16 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=16.RAW SUBJECT_SAMPLE_FACTORS - 17 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=17.RAW SUBJECT_SAMPLE_FACTORS - 18 Fiber:Mix | Timepoint:20 | Sex:F RAW_FILE_NAME=18.RAW SUBJECT_SAMPLE_FACTORS - 19 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=19.RAW SUBJECT_SAMPLE_FACTORS - 20 Fiber:Inulin | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=20.RAW SUBJECT_SAMPLE_FACTORS - 21 Fiber:Mix | Timepoint:10 | Sex:M RAW_FILE_NAME=21.RAW SUBJECT_SAMPLE_FACTORS - 22 Fiber:Mix | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=22.RAW SUBJECT_SAMPLE_FACTORS - 23 Fiber:Mix | Timepoint:30 | Sex:F RAW_FILE_NAME=23.RAW SUBJECT_SAMPLE_FACTORS - 24 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=24.RAW SUBJECT_SAMPLE_FACTORS - 25 Fiber:Inulin | Timepoint:30 | Sex:F RAW_FILE_NAME=25.RAW SUBJECT_SAMPLE_FACTORS - 26 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=26.RAW SUBJECT_SAMPLE_FACTORS - 27 Fiber:Mix | Timepoint:10 | Sex:F RAW_FILE_NAME=27.RAW SUBJECT_SAMPLE_FACTORS - 28 Fiber:Inulin | Timepoint:10 | Sex:F RAW_FILE_NAME=28.RAW SUBJECT_SAMPLE_FACTORS - 29 Fiber:Mix | Timepoint:10 | Sex:F RAW_FILE_NAME=29.RAW SUBJECT_SAMPLE_FACTORS - 30 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=30.RAW SUBJECT_SAMPLE_FACTORS - 31 Fiber:Inulin | Timepoint:Washout Week 3 | Sex:M RAW_FILE_NAME=31.RAW SUBJECT_SAMPLE_FACTORS - 32 Fiber:Mix | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=32.RAW SUBJECT_SAMPLE_FACTORS - 33 Fiber:Mix | Timepoint:30 | Sex:M RAW_FILE_NAME=33.RAW SUBJECT_SAMPLE_FACTORS - 34 Fiber:Inulin | Timepoint:10 | Sex:M RAW_FILE_NAME=34.RAW SUBJECT_SAMPLE_FACTORS - 35 Fiber:Inulin | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=35.RAW SUBJECT_SAMPLE_FACTORS - 36 Fiber:Inulin | Timepoint:30 | Sex:F RAW_FILE_NAME=36.RAW SUBJECT_SAMPLE_FACTORS - 37 Fiber:Mix | Timepoint:10 | Sex:F RAW_FILE_NAME=37.RAW SUBJECT_SAMPLE_FACTORS - 38 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=38.RAW SUBJECT_SAMPLE_FACTORS - 39 Fiber:Arabinoxylan | Timepoint:10 | Sex:M RAW_FILE_NAME=39.RAW SUBJECT_SAMPLE_FACTORS - 40 Fiber:Inulin | Timepoint:Baseline | Sex:M RAW_FILE_NAME=40.RAW SUBJECT_SAMPLE_FACTORS - 41 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=41.RAW SUBJECT_SAMPLE_FACTORS - 42 Fiber:Mix | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=42.RAW SUBJECT_SAMPLE_FACTORS - 43 Fiber:Inulin | Timepoint:Baseline | Sex:F RAW_FILE_NAME=43.RAW SUBJECT_SAMPLE_FACTORS - 44 Fiber:Arabinoxylan | Timepoint:10 | Sex:M RAW_FILE_NAME=44.RAW SUBJECT_SAMPLE_FACTORS - 45 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M RAW_FILE_NAME=45.RAW SUBJECT_SAMPLE_FACTORS - 46 Fiber:Mix | Timepoint:Baseline | Sex:M RAW_FILE_NAME=46.RAW SUBJECT_SAMPLE_FACTORS - 47 Fiber:Mix | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=47.RAW SUBJECT_SAMPLE_FACTORS - 48 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M RAW_FILE_NAME=48.RAW SUBJECT_SAMPLE_FACTORS - 49 Fiber:Mix | Timepoint:30 | Sex:M RAW_FILE_NAME=49.RAW SUBJECT_SAMPLE_FACTORS - 50 Fiber:Inulin | Timepoint:20 | Sex:M RAW_FILE_NAME=50.RAW SUBJECT_SAMPLE_FACTORS - 51 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=51.RAW SUBJECT_SAMPLE_FACTORS - 52 Fiber:Inulin | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=52.RAW SUBJECT_SAMPLE_FACTORS - 53 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=53.RAW SUBJECT_SAMPLE_FACTORS - 54 Fiber:Arabinoxylan | Timepoint:30 | Sex:F RAW_FILE_NAME=54.RAW SUBJECT_SAMPLE_FACTORS - 55 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F RAW_FILE_NAME=55.RAW SUBJECT_SAMPLE_FACTORS - 56 Fiber:Inulin | Timepoint:Baseline | Sex:F RAW_FILE_NAME=56.RAW SUBJECT_SAMPLE_FACTORS - 57 Fiber:Mix | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=57.RAW SUBJECT_SAMPLE_FACTORS - 58 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M RAW_FILE_NAME=58.RAW SUBJECT_SAMPLE_FACTORS - 59 Fiber:Inulin | Timepoint:30 | Sex:F RAW_FILE_NAME=59.RAW SUBJECT_SAMPLE_FACTORS - 60 Fiber:Inulin | Timepoint:30 | Sex:M RAW_FILE_NAME=60.RAW SUBJECT_SAMPLE_FACTORS - 61 Fiber:Arabinoxylan | Timepoint:30 | Sex:F RAW_FILE_NAME=61.RAW SUBJECT_SAMPLE_FACTORS - 62 Fiber:Mix | Timepoint:30 | Sex:F RAW_FILE_NAME=62.RAW SUBJECT_SAMPLE_FACTORS - 63 Fiber:Arabinoxylan | Timepoint:20 | Sex:F RAW_FILE_NAME=63.RAW SUBJECT_SAMPLE_FACTORS - 64 Fiber:Inulin | Timepoint:10 | Sex:M RAW_FILE_NAME=64.RAW SUBJECT_SAMPLE_FACTORS - 67 Fiber:Inulin | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=67.RAW SUBJECT_SAMPLE_FACTORS - 68 Fiber:Inulin | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=68.RAW SUBJECT_SAMPLE_FACTORS - 69 Fiber:Mix | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=69.RAW SUBJECT_SAMPLE_FACTORS - 70 Fiber:Inulin | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=70.RAW SUBJECT_SAMPLE_FACTORS - 71 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F RAW_FILE_NAME=71.RAW SUBJECT_SAMPLE_FACTORS - 73 Fiber:Mix | Timepoint:30 | Sex:F RAW_FILE_NAME=73.RAW SUBJECT_SAMPLE_FACTORS - 74 Fiber:Inulin | Timepoint:20 | Sex:F RAW_FILE_NAME=74.RAW SUBJECT_SAMPLE_FACTORS - 75 Fiber:Inulin | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=75.RAW SUBJECT_SAMPLE_FACTORS - 76 Fiber:Inulin | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=76.RAW SUBJECT_SAMPLE_FACTORS - 77 Fiber:Inulin | Timepoint:Baseline | Sex:M RAW_FILE_NAME=77.RAW SUBJECT_SAMPLE_FACTORS - 78 Fiber:Mix | Timepoint:30 | Sex:M RAW_FILE_NAME=78.RAW SUBJECT_SAMPLE_FACTORS - 79 Fiber:Inulin | Timepoint:Baseline | Sex:F RAW_FILE_NAME=79.RAW SUBJECT_SAMPLE_FACTORS - 80 Fiber:Arabinoxylan | Timepoint:30 | Sex:F RAW_FILE_NAME=80.RAW SUBJECT_SAMPLE_FACTORS - 81 Fiber:Inulin | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=81.RAW SUBJECT_SAMPLE_FACTORS - 82 Fiber:Inulin | Timepoint:10 | Sex:F RAW_FILE_NAME=82.RAW SUBJECT_SAMPLE_FACTORS - 83 Fiber:Inulin | Timepoint:20 | Sex:F RAW_FILE_NAME=83.RAW SUBJECT_SAMPLE_FACTORS - 84 Fiber:Arabinoxylan | Timepoint:30 | Sex:M RAW_FILE_NAME=84.RAW SUBJECT_SAMPLE_FACTORS - 85 Fiber:Mix | Timepoint:20 | Sex:F RAW_FILE_NAME=85.RAW SUBJECT_SAMPLE_FACTORS - 86 Fiber:Inulin | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=86.RAW SUBJECT_SAMPLE_FACTORS - 87 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=87.RAW SUBJECT_SAMPLE_FACTORS - 88 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=88.RAW SUBJECT_SAMPLE_FACTORS - 89 Fiber:Mix | Timepoint:20 | Sex:M RAW_FILE_NAME=89.RAW SUBJECT_SAMPLE_FACTORS - 90 Fiber:Inulin | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=90.RAW SUBJECT_SAMPLE_FACTORS - 91 Fiber:Inulin | Timepoint:10 | Sex:M RAW_FILE_NAME=91.RAW SUBJECT_SAMPLE_FACTORS - 92 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=92.RAW SUBJECT_SAMPLE_FACTORS - 93 Fiber:Inulin | Timepoint:20 | Sex:M RAW_FILE_NAME=93.RAW SUBJECT_SAMPLE_FACTORS - 94 Fiber:Arabinoxylan | Timepoint:Week 2 | Sex:M RAW_FILE_NAME=94.RAW SUBJECT_SAMPLE_FACTORS - 95 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=95.RAW SUBJECT_SAMPLE_FACTORS - 96 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=96.RAW SUBJECT_SAMPLE_FACTORS - 97 Fiber:Mix | Timepoint:30 | Sex:F RAW_FILE_NAME=97.RAW SUBJECT_SAMPLE_FACTORS - 98 Fiber:Inulin | Timepoint:Baseline | Sex:F RAW_FILE_NAME=98.RAW SUBJECT_SAMPLE_FACTORS - 99 Fiber:Mix | Timepoint:20 | Sex:F RAW_FILE_NAME=99.RAW SUBJECT_SAMPLE_FACTORS - 100 Fiber:Mix | Timepoint:10 | Sex:M RAW_FILE_NAME=100.RAW SUBJECT_SAMPLE_FACTORS - 101 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=101.RAW SUBJECT_SAMPLE_FACTORS - 102 Fiber:Arabinoxylan | Timepoint:30 | Sex:F RAW_FILE_NAME=102.RAW SUBJECT_SAMPLE_FACTORS - 103 Fiber:Mix | Timepoint:Baseline | Sex:M RAW_FILE_NAME=103.RAW SUBJECT_SAMPLE_FACTORS - 104 Fiber:Mix | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=104.RAW SUBJECT_SAMPLE_FACTORS - 105 Fiber:Mix | Timepoint:10 | Sex:F RAW_FILE_NAME=105.RAW SUBJECT_SAMPLE_FACTORS - 106 Fiber:Arabinoxylan | Timepoint:10 | Sex:M RAW_FILE_NAME=106.RAW SUBJECT_SAMPLE_FACTORS - 107 Fiber:Inulin | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=107.RAW SUBJECT_SAMPLE_FACTORS - 108 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=108.RAW SUBJECT_SAMPLE_FACTORS - 109 Fiber:Inulin | Timepoint:20 | Sex:M RAW_FILE_NAME=109.RAW SUBJECT_SAMPLE_FACTORS - 110 Fiber:Inulin | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=110.RAW SUBJECT_SAMPLE_FACTORS - 111 Fiber:Mix | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=111.RAW SUBJECT_SAMPLE_FACTORS - 112 Fiber:Mix | Timepoint:Baseline | Sex:F RAW_FILE_NAME=112.RAW SUBJECT_SAMPLE_FACTORS - 113 Fiber:Inulin | Timepoint:30 | Sex:F RAW_FILE_NAME=113.RAW SUBJECT_SAMPLE_FACTORS - 114 Fiber:Mix | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=114.RAW SUBJECT_SAMPLE_FACTORS - 115 Fiber:Mix | Timepoint:20 | Sex:F RAW_FILE_NAME=115.RAW SUBJECT_SAMPLE_FACTORS - 116 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F RAW_FILE_NAME=116.RAW SUBJECT_SAMPLE_FACTORS - 117 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=117.RAW SUBJECT_SAMPLE_FACTORS - 118 Fiber:Mix | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=118.RAW SUBJECT_SAMPLE_FACTORS - 119 Fiber:Mix | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=119.RAW SUBJECT_SAMPLE_FACTORS - 120 Fiber:Inulin | Timepoint:30 | Sex:F RAW_FILE_NAME=120.RAW SUBJECT_SAMPLE_FACTORS - 122 Fiber:Inulin | Timepoint:- | Sex:M RAW_FILE_NAME=122.RAW SUBJECT_SAMPLE_FACTORS - 124 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=124.RAW SUBJECT_SAMPLE_FACTORS - 126 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F RAW_FILE_NAME=126.RAW SUBJECT_SAMPLE_FACTORS - 127 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=127.RAW SUBJECT_SAMPLE_FACTORS - 128 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F RAW_FILE_NAME=128.RAW SUBJECT_SAMPLE_FACTORS - 129 Fiber:Inulin | Timepoint:20 | Sex:F RAW_FILE_NAME=129.RAW SUBJECT_SAMPLE_FACTORS - 130 Fiber:Mix | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=130.RAW SUBJECT_SAMPLE_FACTORS - 131 Fiber:Inulin | Timepoint:10 | Sex:M RAW_FILE_NAME=131.RAW SUBJECT_SAMPLE_FACTORS - 132 Fiber:Arabinoxylan | Timepoint:10 | Sex:M RAW_FILE_NAME=132.RAW SUBJECT_SAMPLE_FACTORS - 133 Fiber:Mix | Timepoint:10 | Sex:F RAW_FILE_NAME=133.RAW SUBJECT_SAMPLE_FACTORS - 134 Fiber:Inulin | Timepoint:Baseline | Sex:F RAW_FILE_NAME=134.RAW SUBJECT_SAMPLE_FACTORS - 135 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=135.RAW SUBJECT_SAMPLE_FACTORS - 136 Fiber:Arabinoxylan | Timepoint:20 | Sex:F RAW_FILE_NAME=136.RAW SUBJECT_SAMPLE_FACTORS - 137 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=137.RAW SUBJECT_SAMPLE_FACTORS - 138 Fiber:Mix | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=138.RAW SUBJECT_SAMPLE_FACTORS - 139 Fiber:Arabinoxylan | Timepoint:20 | Sex:M RAW_FILE_NAME=139.RAW SUBJECT_SAMPLE_FACTORS - 140 Fiber:Inulin | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=140.RAW SUBJECT_SAMPLE_FACTORS - 141 Fiber:Inulin | Timepoint:30 | Sex:M RAW_FILE_NAME=141.RAW SUBJECT_SAMPLE_FACTORS - 142 Fiber:Mix | Timepoint:Baseline | Sex:M RAW_FILE_NAME=142.RAW SUBJECT_SAMPLE_FACTORS - 143 Fiber:Mix | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=143.RAW SUBJECT_SAMPLE_FACTORS - 144 Fiber:Arabinoxylan | Timepoint:Washout D30 | Sex:M RAW_FILE_NAME=144.RAW SUBJECT_SAMPLE_FACTORS - 145 Fiber:Inulin | Timepoint:30 | Sex:M RAW_FILE_NAME=145.RAW SUBJECT_SAMPLE_FACTORS - 146 Fiber:Inulin | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=146.RAW SUBJECT_SAMPLE_FACTORS - 147 Fiber:Inulin | Timepoint:10 | Sex:M RAW_FILE_NAME=147.RAW SUBJECT_SAMPLE_FACTORS - 148 Fiber:Mix | Timepoint:20 | Sex:M RAW_FILE_NAME=148.RAW SUBJECT_SAMPLE_FACTORS - 149 Fiber:Arabinoxylan | Timepoint:20 | Sex:F RAW_FILE_NAME=149.RAW SUBJECT_SAMPLE_FACTORS - 150 Fiber:Inulin | Timepoint:10 | Sex:M RAW_FILE_NAME=150.RAW SUBJECT_SAMPLE_FACTORS - 151 Fiber:Inulin | Timepoint:10 | Sex:F RAW_FILE_NAME=151.RAW SUBJECT_SAMPLE_FACTORS - 152 Fiber:Inulin | Timepoint:10 | Sex:F RAW_FILE_NAME=152.RAW SUBJECT_SAMPLE_FACTORS - 153 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F RAW_FILE_NAME=153.RAW SUBJECT_SAMPLE_FACTORS - 154 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M RAW_FILE_NAME=154.RAW SUBJECT_SAMPLE_FACTORS - 155 Fiber:Arabinoxylan | Timepoint:30 | Sex:M RAW_FILE_NAME=155.RAW SUBJECT_SAMPLE_FACTORS - 156 Fiber:Mix | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=156.RAW SUBJECT_SAMPLE_FACTORS - 157 Fiber:Mix | Timepoint:10 | Sex:M RAW_FILE_NAME=157.RAW SUBJECT_SAMPLE_FACTORS - 158 Fiber:Arabinoxylan | Timepoint:Month 1 | Sex:M RAW_FILE_NAME=158.RAW SUBJECT_SAMPLE_FACTORS - 159 Fiber:Inulin | Timepoint:20 | Sex:M RAW_FILE_NAME=159.RAW SUBJECT_SAMPLE_FACTORS - 161 Fiber:Mix | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=161.RAW SUBJECT_SAMPLE_FACTORS - 163 Fiber:Mix | Timepoint:Baseline | Sex:M RAW_FILE_NAME=163.RAW SUBJECT_SAMPLE_FACTORS - 164 Fiber:Arabinoxylan | Timepoint:20 | Sex:M RAW_FILE_NAME=164.RAW SUBJECT_SAMPLE_FACTORS - 165 Fiber:Arabinoxylan | Timepoint:30 | Sex:M RAW_FILE_NAME=165.RAW SUBJECT_SAMPLE_FACTORS - 166 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=166.RAW SUBJECT_SAMPLE_FACTORS - 167 Fiber:Mix | Timepoint:Baseline | Sex:M RAW_FILE_NAME=167.RAW SUBJECT_SAMPLE_FACTORS - 168 Fiber:Inulin | Timepoint:10 | Sex:M RAW_FILE_NAME=168.RAW SUBJECT_SAMPLE_FACTORS - 169 Fiber:Inulin | Timepoint:20 | Sex:F RAW_FILE_NAME=169.RAW SUBJECT_SAMPLE_FACTORS - 170 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=170.RAW SUBJECT_SAMPLE_FACTORS - 171 Fiber:Mix | Timepoint:10 | Sex:F RAW_FILE_NAME=171.RAW SUBJECT_SAMPLE_FACTORS - 172 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=172.RAW SUBJECT_SAMPLE_FACTORS - 173 Fiber:Arabinoxylan | Timepoint:20 | Sex:F RAW_FILE_NAME=173.RAW SUBJECT_SAMPLE_FACTORS - 174 Fiber:Inulin | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=174.RAW SUBJECT_SAMPLE_FACTORS - 175 Fiber:Inulin | Timepoint:20 | Sex:M RAW_FILE_NAME=175.RAW SUBJECT_SAMPLE_FACTORS - 176 Fiber:Arabinoxylan | Timepoint:20 | Sex:M RAW_FILE_NAME=176.RAW SUBJECT_SAMPLE_FACTORS - 177 Fiber:Inulin | Timepoint:Baseline | Sex:M RAW_FILE_NAME=177.RAW SUBJECT_SAMPLE_FACTORS - 178 Fiber:Mix | Timepoint:30 | Sex:M RAW_FILE_NAME=178.RAW SUBJECT_SAMPLE_FACTORS - 179 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=179.RAW SUBJECT_SAMPLE_FACTORS - 180 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=180.RAW SUBJECT_SAMPLE_FACTORS - 181 Fiber:Mix | Timepoint:10 | Sex:F RAW_FILE_NAME=181.RAW SUBJECT_SAMPLE_FACTORS - 182 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=182.RAW SUBJECT_SAMPLE_FACTORS - 183 Fiber:Arabinoxylan | Timepoint:30 | Sex:F RAW_FILE_NAME=183.RAW SUBJECT_SAMPLE_FACTORS - 184 Fiber:Inulin | Timepoint:30 | Sex:F RAW_FILE_NAME=184.RAW SUBJECT_SAMPLE_FACTORS - 185 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=185.RAW SUBJECT_SAMPLE_FACTORS - 186 Fiber:Inulin | Timepoint:30 | Sex:F RAW_FILE_NAME=186.RAW SUBJECT_SAMPLE_FACTORS - 188 Fiber:Inulin | Timepoint:20 | Sex:M RAW_FILE_NAME=188.RAW SUBJECT_SAMPLE_FACTORS - 189 Fiber:Inulin | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=189.RAW SUBJECT_SAMPLE_FACTORS - 190 Fiber:Inulin | Timepoint:30 | Sex:M RAW_FILE_NAME=190.RAW SUBJECT_SAMPLE_FACTORS - 191 Fiber:Mix | Timepoint:20 | Sex:F RAW_FILE_NAME=191.RAW SUBJECT_SAMPLE_FACTORS - 192 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F RAW_FILE_NAME=192.RAW SUBJECT_SAMPLE_FACTORS - 193 Fiber:Mix | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=193.RAW SUBJECT_SAMPLE_FACTORS - 194 Fiber:Mix | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=194.RAW SUBJECT_SAMPLE_FACTORS - 195 Fiber:Inulin | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=195.RAW SUBJECT_SAMPLE_FACTORS - 197 Fiber:Mix | Timepoint:20 | Sex:M RAW_FILE_NAME=197.RAW SUBJECT_SAMPLE_FACTORS - 198 Fiber:Inulin | Timepoint:10 | Sex:M RAW_FILE_NAME=198.RAW SUBJECT_SAMPLE_FACTORS - 199 Fiber:Inulin | Timepoint:20 | Sex:F RAW_FILE_NAME=199.RAW SUBJECT_SAMPLE_FACTORS - 201 Fiber:Mix | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=201.RAW SUBJECT_SAMPLE_FACTORS - 203 Fiber:Mix | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=203.RAW SUBJECT_SAMPLE_FACTORS - 204 Fiber:Arabinoxylan | Timepoint:10 | Sex:M RAW_FILE_NAME=204.RAW SUBJECT_SAMPLE_FACTORS - 205 Fiber:Inulin | Timepoint:10 | Sex:F RAW_FILE_NAME=205.RAW SUBJECT_SAMPLE_FACTORS - 206 Fiber:Arabinoxylan | Timepoint:30 | Sex:M RAW_FILE_NAME=206.RAW SUBJECT_SAMPLE_FACTORS - 207 Fiber:Mix | Timepoint:30 | Sex:F RAW_FILE_NAME=207.RAW SUBJECT_SAMPLE_FACTORS - 208 Fiber:Inulin | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=208.RAW SUBJECT_SAMPLE_FACTORS - 209 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=209.RAW SUBJECT_SAMPLE_FACTORS - 210 Fiber:Inulin | Timepoint:10 | Sex:M RAW_FILE_NAME=210.RAW SUBJECT_SAMPLE_FACTORS - 211 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F RAW_FILE_NAME=211.RAW SUBJECT_SAMPLE_FACTORS - 213 Fiber:Mix | Timepoint:Baseline | Sex:F RAW_FILE_NAME=213.RAW SUBJECT_SAMPLE_FACTORS - 214 Fiber:Inulin | Timepoint:20 | Sex:F RAW_FILE_NAME=214.RAW SUBJECT_SAMPLE_FACTORS - 215 Fiber:Arabinoxylan | Timepoint:30 | Sex:F RAW_FILE_NAME=215.RAW SUBJECT_SAMPLE_FACTORS - 216 Fiber:Inulin | Timepoint:Baseline | Sex:M RAW_FILE_NAME=216.RAW SUBJECT_SAMPLE_FACTORS - 217 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=217.RAW SUBJECT_SAMPLE_FACTORS - 218 Fiber:Arabinoxylan | Timepoint:20 | Sex:F RAW_FILE_NAME=218.RAW SUBJECT_SAMPLE_FACTORS - 219 Fiber:Inulin | Timepoint:10 | Sex:F RAW_FILE_NAME=219.RAW SUBJECT_SAMPLE_FACTORS - 220 Fiber:Inulin | Timepoint:Baseline | Sex:F RAW_FILE_NAME=220.RAW SUBJECT_SAMPLE_FACTORS - 221 Fiber:Inulin | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=221.RAW SUBJECT_SAMPLE_FACTORS - 222 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F RAW_FILE_NAME=222.RAW SUBJECT_SAMPLE_FACTORS - 223 Fiber:Mix | Timepoint:Baseline | Sex:M RAW_FILE_NAME=223.RAW SUBJECT_SAMPLE_FACTORS - 224 Fiber:Inulin | Timepoint:10 | Sex:F RAW_FILE_NAME=224.RAW SUBJECT_SAMPLE_FACTORS - 225 Fiber:Inulin | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=225.RAW SUBJECT_SAMPLE_FACTORS - 226 Fiber:Arabinoxylan | Timepoint:10 | Sex:M RAW_FILE_NAME=226.RAW SUBJECT_SAMPLE_FACTORS - 227 Fiber:Inulin | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=227.RAW SUBJECT_SAMPLE_FACTORS - 228 Fiber:Arabinoxylan | Timepoint:10 | Sex:M RAW_FILE_NAME=228.RAW SUBJECT_SAMPLE_FACTORS - 229 Fiber:Mix | Timepoint:20 | Sex:F RAW_FILE_NAME=229.RAW SUBJECT_SAMPLE_FACTORS - 230 Fiber:Inulin | Timepoint:30 | Sex:M RAW_FILE_NAME=230.RAW SUBJECT_SAMPLE_FACTORS - 231 Fiber:Arabinoxylan | Timepoint:30 | Sex:F RAW_FILE_NAME=231.RAW SUBJECT_SAMPLE_FACTORS - 232 Fiber:Inulin | Timepoint:30 | Sex:F RAW_FILE_NAME=232.RAW SUBJECT_SAMPLE_FACTORS - 233 Fiber:Inulin | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=233.RAW SUBJECT_SAMPLE_FACTORS - 234 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=234.RAW SUBJECT_SAMPLE_FACTORS - 235 Fiber:Mix | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=235.RAW SUBJECT_SAMPLE_FACTORS - 237 Fiber:Inulin | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=237.RAW SUBJECT_SAMPLE_FACTORS - 238 Fiber:Arabinoxylan | Timepoint:30 | Sex:M RAW_FILE_NAME=238.RAW SUBJECT_SAMPLE_FACTORS - 239 Fiber:Inulin | Timepoint:Baseline | Sex:F RAW_FILE_NAME=239.RAW SUBJECT_SAMPLE_FACTORS - 240 Fiber:Mix | Timepoint:10 | Sex:M RAW_FILE_NAME=240.RAW SUBJECT_SAMPLE_FACTORS - 242 Fiber:Mix | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=242.RAW SUBJECT_SAMPLE_FACTORS - 243 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=243.RAW SUBJECT_SAMPLE_FACTORS - 244 Fiber:Arabinoxylan | Timepoint:20 | Sex:F RAW_FILE_NAME=244.RAW SUBJECT_SAMPLE_FACTORS - 245 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M RAW_FILE_NAME=245.RAW SUBJECT_SAMPLE_FACTORS - 246 Fiber:Inulin | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=246.RAW SUBJECT_SAMPLE_FACTORS - 248 Fiber:Inulin | Timepoint:Baseline | Sex:F RAW_FILE_NAME=248.RAW SUBJECT_SAMPLE_FACTORS - 249 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=249.RAW SUBJECT_SAMPLE_FACTORS - 250 Fiber:Arabinoxylan | Timepoint:30 | Sex:M RAW_FILE_NAME=250.RAW SUBJECT_SAMPLE_FACTORS - 251 Fiber:Mix | Timepoint:20 | Sex:M RAW_FILE_NAME=251.RAW SUBJECT_SAMPLE_FACTORS - 252 Fiber:Inulin | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=252.RAW SUBJECT_SAMPLE_FACTORS - 253 Fiber:Inulin | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=253.RAW SUBJECT_SAMPLE_FACTORS - 254 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=254.RAW SUBJECT_SAMPLE_FACTORS - 255 Fiber:Arabinoxylan | Timepoint:Washout Week 3 | Sex:M RAW_FILE_NAME=255.RAW SUBJECT_SAMPLE_FACTORS - 256 Fiber:Arabinoxylan | Timepoint:Week2 2 | Sex:M RAW_FILE_NAME=256.RAW SUBJECT_SAMPLE_FACTORS - 257 Fiber:Inulin | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=257.RAW SUBJECT_SAMPLE_FACTORS - 258 Fiber:Mix | Timepoint:? | Sex:F RAW_FILE_NAME=258.RAW SUBJECT_SAMPLE_FACTORS - 259 Fiber:Inulin | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=259.RAW SUBJECT_SAMPLE_FACTORS - 260 Fiber:Inulin | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=260.RAW SUBJECT_SAMPLE_FACTORS - 261 Fiber:Inulin | Timepoint:Baseline | Sex:M RAW_FILE_NAME=261.RAW SUBJECT_SAMPLE_FACTORS - 262 Fiber:Arabinoxylan | Timepoint:20 | Sex:F RAW_FILE_NAME=262.RAW SUBJECT_SAMPLE_FACTORS - 263 Fiber:Arabinoxylan | Timepoint:Month 2 | Sex:M RAW_FILE_NAME=263.RAW SUBJECT_SAMPLE_FACTORS - 264 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=264.RAW SUBJECT_SAMPLE_FACTORS - 265 Fiber:Inulin | Timepoint:20 | Sex:M RAW_FILE_NAME=265.RAW SUBJECT_SAMPLE_FACTORS - 266 Fiber:Mix | Timepoint:10 | Sex:F RAW_FILE_NAME=266.RAW SUBJECT_SAMPLE_FACTORS - 267 Fiber:Mix | Timepoint:10 | Sex:F RAW_FILE_NAME=267.RAW SUBJECT_SAMPLE_FACTORS - 268 Fiber:Inulin | Timepoint:10 | Sex:F RAW_FILE_NAME=268.RAW SUBJECT_SAMPLE_FACTORS - 269 Fiber:Mix | Timepoint:20 | Sex:F RAW_FILE_NAME=269.RAW SUBJECT_SAMPLE_FACTORS - 270 Fiber:Mix | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=270.RAW SUBJECT_SAMPLE_FACTORS - 271 Fiber:Arabinoxylan | Timepoint:Month 3 | Sex:M RAW_FILE_NAME=271.RAW SUBJECT_SAMPLE_FACTORS - 272 Fiber:Arabinoxylan | Timepoint:20 | Sex:M RAW_FILE_NAME=272.RAW SUBJECT_SAMPLE_FACTORS - 273 Fiber:Arabinoxylan | Timepoint:Month 3 | Sex:M RAW_FILE_NAME=273.RAW SUBJECT_SAMPLE_FACTORS - 274 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=274.RAW SUBJECT_SAMPLE_FACTORS - 275 Fiber:Arabinoxylan | Timepoint:30 | Sex:F RAW_FILE_NAME=275.RAW SUBJECT_SAMPLE_FACTORS - 276 Fiber:Arabinoxylan | Timepoint:30 | Sex:F RAW_FILE_NAME=276.RAW SUBJECT_SAMPLE_FACTORS - 277 Fiber:Mix | Timepoint:Baseline | Sex:F RAW_FILE_NAME=277.RAW SUBJECT_SAMPLE_FACTORS - 278 Fiber:Inulin | Timepoint:30 | Sex:M RAW_FILE_NAME=278.RAW SUBJECT_SAMPLE_FACTORS - 279 Fiber:Arabinoxylan | Timepoint:Month 1 | Sex:M RAW_FILE_NAME=279.RAW SUBJECT_SAMPLE_FACTORS - 280 Fiber:Inulin | Timepoint:Washout Week 3 | Sex:M RAW_FILE_NAME=280.RAW SUBJECT_SAMPLE_FACTORS - 281 Fiber:Inulin | Timepoint:Baseline | Sex:F RAW_FILE_NAME=281.RAW SUBJECT_SAMPLE_FACTORS - 282 Fiber:Inulin | Timepoint:Baseline | Sex:M RAW_FILE_NAME=282.RAW SUBJECT_SAMPLE_FACTORS - 283 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=283.RAW SUBJECT_SAMPLE_FACTORS - 284 Fiber:Arabinoxylan | Timepoint:30 | Sex:F RAW_FILE_NAME=284.RAW SUBJECT_SAMPLE_FACTORS - 285 Fiber:Inulin | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=285.RAW SUBJECT_SAMPLE_FACTORS - 286 Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=286.RAW SUBJECT_SAMPLE_FACTORS - 287 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M RAW_FILE_NAME=287.RAW SUBJECT_SAMPLE_FACTORS - 288 Fiber:Mix | Timepoint:30 | Sex:M RAW_FILE_NAME=288.RAW SUBJECT_SAMPLE_FACTORS - 289 Fiber:Inulin | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=289.RAW SUBJECT_SAMPLE_FACTORS - 290 Fiber:Inulin | Timepoint:30 | Sex:M RAW_FILE_NAME=290.RAW SUBJECT_SAMPLE_FACTORS - 291 Fiber:Mix | Timepoint:10 | Sex:M RAW_FILE_NAME=291.RAW SUBJECT_SAMPLE_FACTORS - 292 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=292.RAW SUBJECT_SAMPLE_FACTORS - 293 Fiber:Mix | Timepoint:30 | Sex:F RAW_FILE_NAME=293.RAW SUBJECT_SAMPLE_FACTORS - 294 Fiber:Inulin | Timepoint:20 | Sex:M RAW_FILE_NAME=294.RAW SUBJECT_SAMPLE_FACTORS - 295 Fiber:Arabinoxylan | Timepoint:20 | Sex:M RAW_FILE_NAME=295.RAW SUBJECT_SAMPLE_FACTORS - 296 Fiber:Inulin | Timepoint:20 | Sex:M RAW_FILE_NAME=296.RAW SUBJECT_SAMPLE_FACTORS - 297 Fiber:Arabinoxylan | Timepoint:10 | Sex:F RAW_FILE_NAME=297.RAW SUBJECT_SAMPLE_FACTORS - 298 Fiber:Inulin | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=298.RAW SUBJECT_SAMPLE_FACTORS - 299 Fiber:Inulin | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=299.RAW SUBJECT_SAMPLE_FACTORS - 300 Fiber:Arabinoxylan | Timepoint:30 | Sex:M RAW_FILE_NAME=300.RAW SUBJECT_SAMPLE_FACTORS - 301 Fiber:Inulin | Timepoint:10 | Sex:F RAW_FILE_NAME=301.RAW SUBJECT_SAMPLE_FACTORS - 303 Fiber:Mix | Timepoint:10 | Sex:M RAW_FILE_NAME=303.RAW SUBJECT_SAMPLE_FACTORS - 304 Fiber:Mix | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=304.RAW SUBJECT_SAMPLE_FACTORS - 305 Fiber:Inulin | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=305.RAW SUBJECT_SAMPLE_FACTORS - 306 Fiber:Mix | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=306.RAW SUBJECT_SAMPLE_FACTORS - 307 Fiber:Mix | Timepoint:Baseline | Sex:F RAW_FILE_NAME=307.RAW SUBJECT_SAMPLE_FACTORS - 308 Fiber:Inulin | Timepoint:20 | Sex:M RAW_FILE_NAME=308.RAW SUBJECT_SAMPLE_FACTORS - 309 Fiber:Inulin | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=309.RAW SUBJECT_SAMPLE_FACTORS - 310 Fiber:Mix | Timepoint:20 | Sex:M RAW_FILE_NAME=310.RAW SUBJECT_SAMPLE_FACTORS - 311 Fiber:Arabinoxylan | Timepoint:20 | Sex:M RAW_FILE_NAME=311.RAW SUBJECT_SAMPLE_FACTORS - 312 Fiber:Inulin | Timepoint:30 | Sex:F RAW_FILE_NAME=312.RAW SUBJECT_SAMPLE_FACTORS - 313 Fiber:Mix | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=313.RAW SUBJECT_SAMPLE_FACTORS - 314 Fiber:Arabinoxylan | Timepoint:20 | Sex:F RAW_FILE_NAME=314.RAW SUBJECT_SAMPLE_FACTORS - 315 Fiber:Inulin | Timepoint:20 | Sex:F RAW_FILE_NAME=315.RAW SUBJECT_SAMPLE_FACTORS - 316 Fiber:Mix | Timepoint:30 | Sex:F RAW_FILE_NAME=316.RAW SUBJECT_SAMPLE_FACTORS - 317 Fiber:Mix | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=317.RAW SUBJECT_SAMPLE_FACTORS - 319 Fiber:Mix | Timepoint:20 | Sex:M RAW_FILE_NAME=319.RAW SUBJECT_SAMPLE_FACTORS - 320 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M RAW_FILE_NAME=320.RAW SUBJECT_SAMPLE_FACTORS - 321 Fiber:Mix | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=321.RAW SUBJECT_SAMPLE_FACTORS - 322 Fiber:Mix | Timepoint:Baseline | Sex:M RAW_FILE_NAME=322.RAW SUBJECT_SAMPLE_FACTORS - 323 Fiber:Mix | Timepoint:20 | Sex:F RAW_FILE_NAME=323.RAW SUBJECT_SAMPLE_FACTORS - 324 Fiber:Mix | Timepoint:Washout Week 3 | Sex:M RAW_FILE_NAME=324.RAW SUBJECT_SAMPLE_FACTORS - 325 Fiber:Arabinoxylan | Timepoint:Month 2 | Sex:M RAW_FILE_NAME=325.RAW SUBJECT_SAMPLE_FACTORS - 326 Fiber:Inulin | Timepoint:Baseline | Sex:M RAW_FILE_NAME=326.RAW SUBJECT_SAMPLE_FACTORS - 327 Fiber:Arabinoxylan | Timepoint:20 | Sex:F RAW_FILE_NAME=327.RAW SUBJECT_SAMPLE_FACTORS - 328 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F RAW_FILE_NAME=328.RAW SUBJECT_SAMPLE_FACTORS - 329 Fiber:Inulin | Timepoint:Baseline | Sex:M RAW_FILE_NAME=329.RAW SUBJECT_SAMPLE_FACTORS - 330 Fiber:Inulin | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=330.RAW SUBJECT_SAMPLE_FACTORS - 331 Fiber:Inulin | Timepoint:20 | Sex:F RAW_FILE_NAME=331.RAW SUBJECT_SAMPLE_FACTORS - 332 Fiber:Mix | Timepoint:30 | Sex:F RAW_FILE_NAME=332.RAW SUBJECT_SAMPLE_FACTORS - 333 Fiber:Mix | Timepoint:Baseline | Sex:F RAW_FILE_NAME=333.RAW SUBJECT_SAMPLE_FACTORS - 334 Fiber:Inulin | Timepoint:Baseline | Sex:M RAW_FILE_NAME=334.RAW SUBJECT_SAMPLE_FACTORS - 335 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M RAW_FILE_NAME=335.RAW SUBJECT_SAMPLE_FACTORS - 336 Fiber:Mix | Timepoint:20 | Sex:F RAW_FILE_NAME=336.RAW SUBJECT_SAMPLE_FACTORS - 337 Fiber:Inulin | Timepoint:20 | Sex:F RAW_FILE_NAME=337.RAW SUBJECT_SAMPLE_FACTORS - 338 Fiber:Mix | Timepoint:Washout D3 | Sex:M RAW_FILE_NAME=338.RAW SUBJECT_SAMPLE_FACTORS - 339 Fiber:Mix | Timepoint:Baseline | Sex:F RAW_FILE_NAME=339.RAW SUBJECT_SAMPLE_FACTORS - 340 Fiber:Inulin | Timepoint:Washout D3 | Sex:F RAW_FILE_NAME=340.RAW SUBJECT_SAMPLE_FACTORS - 341 Fiber:Mix | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=341.RAW SUBJECT_SAMPLE_FACTORS - 342 Fiber:Inulin | Timepoint:10 | Sex:M RAW_FILE_NAME=342.RAW SUBJECT_SAMPLE_FACTORS - 343 Fiber:Arabinoxylan | Timepoint:30 | Sex:M RAW_FILE_NAME=343.RAW SUBJECT_SAMPLE_FACTORS - 345 Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M RAW_FILE_NAME=345.RAW SUBJECT_SAMPLE_FACTORS - 346 Fiber:Inulin | Timepoint:30 | Sex:M RAW_FILE_NAME=346.RAW SUBJECT_SAMPLE_FACTORS - 347 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=347.RAW SUBJECT_SAMPLE_FACTORS - 348 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=348.RAW SUBJECT_SAMPLE_FACTORS - 349 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=349.RAW SUBJECT_SAMPLE_FACTORS - 350 Fiber:Inulin | Timepoint:30 | Sex:M RAW_FILE_NAME=350.RAW SUBJECT_SAMPLE_FACTORS - 351 Fiber:Mix | Timepoint:10 | Sex:M RAW_FILE_NAME=351.RAW SUBJECT_SAMPLE_FACTORS - 352 Fiber:Inulin | Timepoint:10 | Sex:F RAW_FILE_NAME=352.RAW SUBJECT_SAMPLE_FACTORS - 354 Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M RAW_FILE_NAME=354.RAW SUBJECT_SAMPLE_FACTORS - 355 Fiber:Inulin | Timepoint:End Washout | Sex:M RAW_FILE_NAME=355.RAW SUBJECT_SAMPLE_FACTORS - 356 Fiber:Mix | Timepoint:Baseline | Sex:F RAW_FILE_NAME=356.RAW SUBJECT_SAMPLE_FACTORS - 357 Fiber:Mix | Timepoint:Washout D10 | Sex:F RAW_FILE_NAME=357.RAW SUBJECT_SAMPLE_FACTORS - 358 Fiber:Inulin | Timepoint:30 | Sex:F RAW_FILE_NAME=358.RAW #COLLECTION CO:COLLECTION_SUMMARY The study is a longitudinal, randomized crossover design in which 18 consented CO:COLLECTION_SUMMARY participants (8 men and 10 women) had their diets periodically supplemented with CO:COLLECTION_SUMMARY two fibers, arabinoxylan (AX) and long-chain inulin, and a mixture of fibers CO:COLLECTION_SUMMARY consisting of equal parts AX, LCI, acacia gum, glucomannans, and resistant CO:COLLECTION_SUMMARY starch. Participants were randomized to consume either AX or LCI first, and the CO:COLLECTION_SUMMARY mixed fibers were always administered last. For each of the fiber cycles, blood, CO:COLLECTION_SUMMARY urine and stool samples were collected at seven timepoints: baseline, end of CO:COLLECTION_SUMMARY week one, end of week two, end of week three, day 3 after end of supplementation CO:COLLECTION_SUMMARY and day 10 after end of supplementation. Blood was fractionated into plasma, CO:COLLECTION_SUMMARY serum and peripheral blood mononucleotide cells (PBMCs). Metabolomics was CO:COLLECTION_SUMMARY performed on the plasma fraction of the blood. Once all samples were in the CO:COLLECTION_SUMMARY correct aliquots, they were stored at -80C. Samples were only thawed when CO:COLLECTION_SUMMARY prepared for analysis for each of the respective omics assay which were all CO:COLLECTION_SUMMARY performed within 5 years of collecting the samples. CO:SAMPLE_TYPE Blood (plasma) #TREATMENT TR:TREATMENT_SUMMARY Participants went through 3 cycles of fiber supplementation, each cycle was TR:TREATMENT_SUMMARY three weeks long with weekly increasing doses of 10 g/day during the first week, TR:TREATMENT_SUMMARY 20g/day during the second week and 30 g/day during the third week. Randomized TR:TREATMENT_SUMMARY for the first two cycles, fibers tested were chicory inulin (99%>5 dp; range TR:TREATMENT_SUMMARY 2-60dp; average >23 dp) and arabinoxylan (psyllium husks powder Now Foods) and a TR:TREATMENT_SUMMARY mix of 5 fibers during the third cycle. The fiber mix included equal amounts of TR:TREATMENT_SUMMARY inulin, arabinoxylan, glucomannan (Now Foods), resistant starch (Hi Maize from TR:TREATMENT_SUMMARY Honeyville), and acacia fiber (Now Foods). Washout period between the cycles was TR:TREATMENT_SUMMARY from 6-10 weeks. Fiber was provided in 10 g sachets and participants were TR:TREATMENT_SUMMARY instructed to resuspend content of the sachet in at least 8 oz of water and TR:TREATMENT_SUMMARY drink one with breakfast for the first week, one with breakfast and one with TR:TREATMENT_SUMMARY dinner during the second week, and one with each meal (breakfast, lunch and TR:TREATMENT_SUMMARY dinner) during the third week. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY We performed an untargeted metabolomics using a platform, previously described SP:SAMPLEPREP_SUMMARY in Contrepois et al., 2015 (Contrepois et al., 2015) to profile plasma extracted SP:SAMPLEPREP_SUMMARY metabolites. Samples were thawed and 100 μL of plasma was transferred into a SP:SAMPLEPREP_SUMMARY 2mL Protein Lobind Eppendorf tube. In order to precipitate and remove proteins, SP:SAMPLEPREP_SUMMARY 400 μL of 1:1:1 methanol:acetonitrile:acetone solution, including 17 internal SP:SAMPLEPREP_SUMMARY standards to control for extraction efficiency and evaluate LC-MS performance, SP:SAMPLEPREP_SUMMARY was added to each plasma sample while on a cold plate. Samples were placed on SP:SAMPLEPREP_SUMMARY the vortex shaker for 15 minutes at 4C then placed at -20C for two hours to SP:SAMPLEPREP_SUMMARY allow for sufficient protein precipitation. Samples were centrifuged at 10,000 SP:SAMPLEPREP_SUMMARY rpm for 10 min at 4C and the supernatant (metabolite extract) from each sample SP:SAMPLEPREP_SUMMARY was carefully removed and placed in a new 2mL Protein Lobind Eppendorf tube. SP:SAMPLEPREP_SUMMARY Samples were placed in the turbovap, evaporated to dryness under nitrogen and SP:SAMPLEPREP_SUMMARY stored at -80C. Before analysis on the MS, samples were reconstituted in 100 μL SP:SAMPLEPREP_SUMMARY 1:1 methanol:water solution and vortexed for 30s, placed in a bath sonicator for SP:SAMPLEPREP_SUMMARY 30s and incubated on ice for 30s. This process was repeated 3 times for all SP:SAMPLEPREP_SUMMARY samples and were centrifuged at 10,000 rpm for 10 min at 4C. The supernatant of SP:SAMPLEPREP_SUMMARY each of these was then transferred to MS tubes and stored at -20C until ran on SP:SAMPLEPREP_SUMMARY the mass spectrometer. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY HILIC experiments were performed using a ZIC-HILIC column 2.1x100 mm, 3.5μm, CH:CHROMATOGRAPHY_SUMMARY 200Å (Merck Millipore) and mobile phase solvents consisting of 10mM ammonium CH:CHROMATOGRAPHY_SUMMARY acetate in 50/50 acetonitrile/water (A) and 10 mM ammonium acetate in 95/5 CH:CHROMATOGRAPHY_SUMMARY acetonitrile/water (B).(Contrepois et al., 2015) CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Thermo Dionex Ultimate 3000 RS CH:COLUMN_NAME SeQuant ZIC-HILIC (100 x 2.1mm, 3.5um) CH:FLOW_RATE .5 ml/min CH:COLUMN_TEMPERATURE 40 CH:SOLVENT_A 10mM ammonium acetate in 50/50 acetonitrile/water CH:SOLVENT_B 10 mM ammonium acetate in 95/5 acetonitrile/water #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Plus Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS Raw data were imported into Progenesis QI 2.3 software (Water, Milford, MA, USA) MS:MS_COMMENTS to align and quantify chromatographic peaks. Data from all 4 acquisition modes MS:MS_COMMENTS (HILIC positive, HILIC negative, RPLC positive, RPLC negative) were processed MS:MS_COMMENTS independently. Using in house R code, we 1) removed noise, 2) imputed data and MS:MS_COMMENTS 3) adjusted for MS drift with time using the LOESS normalization method on MS:MS_COMMENTS pooled QCs injected every 10 injections in the sequence. We used MetID and our MS:MS_COMMENTS MS/MS data to identify 12740 metabolites with confidence levels ranging from MS:MS_COMMENTS 1-3, where 1 matches MS/MS, retention time and m/z from standards on our MS:MS_COMMENTS platform (843 metabolites), 2 has MS/MS and m/z matches from a database (395 MS:MS_COMMENTS metabolites), and 3 matches the m/z of a database (11,502). MS:MS_RESULTS_FILE ST002112_AN004116_Results.txt UNITS:Area Has m/z:Yes Has RT:Yes RT units:Minutes #END