MGP Database

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MGP001748

Ontology/Pathway Information

Entrez Gene ID3791
Gene Namekinase insert domain receptor
Gene Symbol KDR
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030054 ISS:UniProtKBCcell junction
GO:0016023 IEA:UniProtKB-SubCellCcytoplasmic membrane-bounded vesicle
GO:0005769 ISS:BHF-UCLCearly endosome
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0005768 IDA:UniProtKBCendosome
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0005576 IEA:UniProtKB-SubCellCextracellular region
GO:0005794 IDA:UniProtKBCGolgi apparatus
GO:0005887 IDA:UniProtKBCintegral component of plasma membrane
GO:0045121 IDA:UniProtKBCmembrane raft
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0097443 ISS:BHF-UCLCsorting endosome
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0019838 IPI:BHF-UCLFgrowth factor binding
GO:0051879 TAS:BHF-UCLFHsp90 protein binding
GO:0005178 IPI:BHF-UCLFintegrin binding
GO:0004713 IDA:UniProtKBFprotein tyrosine kinase activity
GO:0004716 TAS:BHF-UCLFreceptor signaling protein tyrosine kinase activity
GO:0004714 TAS:BHF-UCLFtransmembrane receptor protein tyrosine kinase activity
GO:0005021 IDA:UniProtKBFvascular endothelial growth factor-activated receptor activity
GO:0038085 IPI:BHF-UCLFvascular endothelial growth factor binding
GO:0001525 TAS:BHF-UCLPangiogenesis
GO:0048754 IEA:EnsemblPbranching morphogenesis of an epithelial tube
GO:0055074 IEA:EnsemblPcalcium ion homeostasis
GO:0035584 IMP:UniProtKBPcalcium-mediated signaling using intracellular calcium source
GO:0045165 IEA:EnsemblPcell fate commitment
GO:0048469 IEA:EnsemblPcell maturation
GO:0002042 ISS:BHF-UCLPcell migration involved in sprouting angiogenesis
GO:0035924 IDA:UniProtKBPcellular response to vascular endothelial growth factor stimulus
GO:0035162 ISS:UniProtKBPembryonic hemopoiesis
GO:0045446 IEA:EnsemblPendothelial cell differentiation
GO:0003158 ISS:UniProtKBPendothelium development
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0048286 IEA:EnsemblPlung alveolus development
GO:0001945 IEA:EnsemblPlymph vessel development
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:2000352 IDA:UniProtKBPnegative regulation of endothelial cell apoptotic process
GO:0001541 IEA:EnsemblPovarian follicle development
GO:0038083 ISS:BHF-UCLPpeptidyl-tyrosine autophosphorylation
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0045766 IMP:UniProtKBPpositive regulation of angiogenesis
GO:0030335 IMP:UniProtKBPpositive regulation of cell migration
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:0010595 IMP:BHF-UCLPpositive regulation of endothelial cell migration
GO:0001938 IMP:UniProtKBPpositive regulation of endothelial cell proliferation
GO:0070374 IMP:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0051894 IDA:BHF-UCLPpositive regulation of focal adhesion assembly
GO:0043410 IDA:UniProtKBPpositive regulation of MAPK cascade
GO:0002053 IEA:EnsemblPpositive regulation of mesenchymal cell proliferation
GO:0051770 IDA:UniProtKBPpositive regulation of nitric-oxide synthase biosynthetic process
GO:0014068 IDA:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0050927 IDA:BHF-UCLPpositive regulation of positive chemotaxis
GO:0001934 IDA:UniProtKBPpositive regulation of protein phosphorylation
GO:2001214 ISS:UniProtKBPpositive regulation of vasculogenesis
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0008360 IDA:BHF-UCLPregulation of cell shape
GO:0023014 TAS:GOCPsignal transduction by phosphorylation
GO:0043129 IEA:EnsemblPsurfactant homeostasis
GO:0007169 TAS:ProtIncPtransmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010 IDA:UniProtKBPvascular endothelial growth factor receptor signaling pathway
GO:0038084 IDA:GOCPvascular endothelial growth factor signaling pathway
GO:0001570 ISS:UniProtKBPvasculogenesis
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18266Axon guidance
REACT_111045Developmental Biology
REACT_264548EPHA-mediated growth cone collapse
REACT_264068EPH-Ephrin signaling
REACT_118779Extracellular matrix organization
REACT_13552Integrin cell surface interactions
REACT_12473Neurophilin interactions with VEGF and VEGFR
REACT_12529Signaling by VEGF
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
REACT_12583VEGF binds to VEGFR leading to receptor dimerization
REACT_12380VEGF ligand-receptor interactions
REACT_264273VEGFR2 mediated cell proliferation
SMP Pathway Links
SMP IDDescription
SMP00420Bevacizumab Action Pathway
SMP00421Vatalanib Action Pathway
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