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MGP003274

Record overview

MGPD IDMGP003274
Gene ID7381
SpeciesHomo sapiens (Human)
Gene Nameubiquinol-cytochrome c reductase binding protein
Gene Symbol UQCRB
SynonymsQPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3;
Alternate namescytochrome b-c1 complex subunit 7; complex III subunit 7; complex III subunit VII; mitochondrial ubiquinone-binding protein; ubiquinol-cytochrome c reductase complex 14 kDa protein; ubiquinol-cytochrome c reductase, complex III subunit VI;
Chromosome8
Map Location8q22
SummaryThis gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]
OrthologsView orthologs and multiple alignments for UQCRB

Proteins

cytochrome b-c1 complex subunit 7 isoform 1
Refseq ID:NP_006285
Protein GI:5454152
UniProt ID:P14927
mRNA ID:NM_006294
Length:111
RefSeq Status:
MAGKQAVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDVKEAIRRLPENLYNDRMFRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIR
ERKEREEWAKK
 
cytochrome b-c1 complex subunit 7 isoform 2
Refseq ID:NP_001186904
Protein GI:316983136
UniProt ID:P14927
mRNA ID:NM_001199975
Length:79
RefSeq Status:
MRDDTIYEDEDVKEAIRRLPENLYNDRMFRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIRERKEREEWAKK
 
cytochrome b-c1 complex subunit 7 isoform 3
Refseq ID:NP_001241681
Protein GI:363498929
UniProt ID:P14927
mRNA ID:NM_001254752
Length:140
RefSeq Status:
MAGKQAVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDVKEAIRRLPENLYNDRMFRIKRALDLNLKHQILPKEQWTKYEEVFAVPALHSASYLD
EKISPLSVPPDPKKSFCEANSHPLNCIETRQRKISTLNRI
 
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