MGP Database

MGP003540

Ontology/Pathway Information

Entrez Gene ID	8394
Gene Name	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Gene Symbol	PIP5K1A
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:HPA	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0005925	IDA:UniProtKB	C	focal adhesion
GO:0030027	IDA:UniProtKB	C	lamellipodium
GO:0016607	IDA:UniProtKB	C	nuclear speck
GO:0005654	IDA:HPA	C	nucleoplasm
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0005886	IDA:UniProtKB	C	plasma membrane
GO:0032587	IDA:UniProtKB	C	ruffle membrane
GO:0016308	IDA:UniProtKB	F	1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0019900	IDA:UniProtKB	F	kinase binding
GO:0031532	IMP:UniProtKB	P	actin cytoskeleton reorganization
GO:0032863	IMP:UniProtKB	P	activation of Rac GTPase activity
GO:0060326	IMP:UniProtKB	P	cell chemotaxis
GO:0016477	NAS:UniProtKB	P	cell migration
GO:0010761	IEA:Ensembl	P	fibroblast migration
GO:0048041	IMP:UniProtKB	P	focal adhesion assembly
GO:0006650	TAS:ProtInc	P	glycerophospholipid metabolic process
GO:0030216	TAS:UniProtKB	P	keratinocyte differentiation
GO:0006909	TAS:UniProtKB	P	phagocytosis
GO:0006661	TAS:Reactome	P	phosphatidylinositol biosynthetic process
GO:0046854	IDA:GOC	P	phosphatidylinositol phosphorylation
GO:0008654	IDA:UniProtKB	P	phospholipid biosynthetic process
GO:0006644	TAS:Reactome	P	phospholipid metabolic process
GO:0072661	IMP:UniProtKB	P	protein targeting to plasma membrane
GO:0097178	IMP:UniProtKB	P	ruffle assembly
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0044281	TAS:Reactome	P	small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_22258	Metabolism of lipids and lipoproteins
REACT_120870	Phospholipid metabolism
REACT_121175	PI Metabolism
REACT_121025	Synthesis of PIPs at the plasma membrane

SMP Pathway Links

SMP ID	Description
SMP00582	Joubert syndrome
SMP00463	Phosphatidylinositol Phosphate Metabolism