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MGP004474

UniProt Annotations

Entry Information
Gene Nametrehalase (brush-border membrane glycoprotein)
Protein EntryTREA_HUMAN
UniProt IDO43280
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43280-1; Sequence=Displayed; Name=2; IsoId=O43280-2; Sequence=VSP_035440; Note=No experimental confirmation available.;
Catalytic ActivityAlpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose.
DiseaseNote=Deficiency of TREH results in isolated trehalose intolerance that causes gastrointestinal symptoms after ingestion of edible mushrooms.
FunctionIntestinal trehalase is probably involved in the hydrolysis of ingested trehalose.
SimilarityBelongs to the glycosyl hydrolase 37 family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
SubunitHomodimer; disulfide-linked. {ECO:0000250}.
Web ResourceName=Wikipedia; Note=Trehalase entry; URL="http://en.wikipedia.org/wiki/Trehalase";
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