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MGP005034

UniProt Annotations

Entry Information
Gene NameAPOBEC1 complementation factor
Protein EntryA1CF_HUMAN
UniProt IDQ9NQ94
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1 {ECO:0000269|PubMed:10781591}; IsoId=Q9NQ94-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:10669759, ECO:0000269|PubMed:10781591}; IsoId=Q9NQ94-2; Sequence=VSP_051929; Note=Major isoform found in 66-78% of cDNA clones. {ECO:0000269|PubMed:11718896}; Name=3; IsoId=Q9NQ94-3; Sequence=VSP_051926, VSP_051929; Name=4 {ECO:0000305}; IsoId=Q9NQ94-4; Sequence=VSP_051927, VSP_051929; Note=Does not exhibit APOBEC1 complementation activity. {ECO:0000269|PubMed:11718896, ECO:0000305}; Name=5 {ECO:0000269|PubMed:11718896}; IsoId=Q9NQ94-5; Sequence=VSP_051925; Note=Does not exhibit APOBEC1 complementation activity. {ECO:0000269|PubMed:11718896}; Name=6 {ECO:0000269|PubMed:11718896}; IsoId=Q9NQ94-6; Sequence=VSP_051928; Note=Minor isoform found in 2-3% of cDNA clones. {ECO:0000269|PubMed:11718896};
DomainThe RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C- terminal regions are required for RNA-binding and for complementing APOBEC1 activity. {ECO:0000269|PubMed:11871661}.
FunctionEssential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. {ECO:0000269|PubMed:10669759, ECO:0000269|PubMed:10781591, ECO:0000269|PubMed:12881431}.
Sequence CautionSequence=BAA91086.1; Type=Frameshift; Positions=148; Evidence={ECO:0000305};
SimilarityContains 3 RRM (RNA recognition motif) domains. {ECO:0000255|PROSITE-ProRule:PRU00176}.
Subcellular LocationNucleus {ECO:0000269|PubMed:12881431}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12881431}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.
SubunitPart of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2 (By similarity). {ECO:0000250}.
Tissue SpecificityWidely expressed with highest levels in brain, liver, pancreas, colon and spleen. {ECO:0000269|PubMed:10669759}.
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